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Aliases for HACD3 Gene

Aliases for HACD3 Gene

  • 3-Hydroxyacyl-CoA Dehydratase 3 2 3 4
  • Protein-Tyrosine Phosphatase-Like A Domain-Containing Protein 1 3 4
  • Protein Tyrosine Phosphatase-Like A Domain Containing 1 2 3
  • Butyrate-Induced Protein 1 3 4
  • PTPLAD1 3 4
  • HB-Ind1 3 4
  • B-IND1 3 4
  • BIND1 3 4
  • Very-Long-Chain (3R)-3-Hydroxyacyl-[Acyl-Carrier Protein] Dehydratase 3 3
  • Very-Long-Chain (3R)-3-Hydroxyacyl-CoA Dehydratase 3 3
  • Protein Tyrosine Phosphatase-Like Protein PTPLAD1 3
  • Butyrate-Induced Transcript 1 3
  • EC 4.2.1.134 4
  • HSPC121 3

External Ids for HACD3 Gene

Previous Symbols for HACD3 Gene

  • PTPLAD1

Summaries for HACD3 Gene

GeneCards Summary for HACD3 Gene

HACD3 (3-Hydroxyacyl-CoA Dehydratase 3) is a Protein Coding gene. An important paralog of this gene is HACD4.

UniProtKB/Swiss-Prot for HACD3 Gene

  • Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression.

Gene Wiki entry for HACD3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HACD3 Gene

Genomics for HACD3 Gene

Genomic Location for HACD3 Gene

Start:
65,530,418 bp from pter
End:
65,578,355 bp from pter
Size:
47,938 bases
Orientation:
Plus strand

Genomic View for HACD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HACD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HACD3 Gene

No data available for Regulatory Elements for HACD3 Gene

Proteins for HACD3 Gene

  • Protein details for HACD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P035-HACD3_HUMAN
    Recommended name:
    Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
    Protein Accession:
    Q9P035
    Secondary Accessions:
    • A0PJA1
    • B4DRF4
    • Q280Z3
    • Q6PD63
    • Q8IUI5
    • Q8NC86
    • Q8NCB1
    • Q96T12
    • Q9NQA7

    Protein attributes for HACD3 Gene

    Size:
    362 amino acids
    Molecular mass:
    43160 Da
    Quaternary structure:
    • May interact with enzymes of the ELO family (including ELOVL1); with those enzymes that mediate condensation, the first of the four steps of the reaction cycle responsible for fatty acids elongation, may be part of a larger fatty acids elongase complex (PubMed:18554506). Interacts with RAC1 (PubMed:10747961).
    SequenceCaution:
    • Sequence=AAF29085.1; Type=Frameshift; Positions=356; Evidence={ECO:0000305}; Sequence=BAC11249.1; Type=Frameshift; Positions=359; Evidence={ECO:0000305};

    Alternative splice isoforms for HACD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HACD3 Gene

Proteomics data for HACD3 Gene at MOPED

Post-translational modifications for HACD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HACD3 Gene

Domains for HACD3 Gene

Protein Domains for HACD3 Gene

UniProtKB/Swiss-Prot:

HACD3_HUMAN
Domain:
  • Contains 1 CS domain.:
    • Q9P035
Family:
  • Belongs to the very long-chain fatty acids dehydratase HACD family.:
    • Q9P035
genes like me logo Genes that share domains with HACD3: view

No data available for Gene Families for HACD3 Gene

Function for HACD3 Gene

Molecular function for HACD3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=49.5 uM for 3-hydroxypalmitoyl-CoA (at 37 degrees Celsius) {ECO:0000269 PubMed:18554506};
UniProtKB/Swiss-Prot CatalyticActivity: A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.
UniProtKB/Swiss-Prot Function: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression.
UniProtKB/Swiss-Prot Induction: By AKAP12 and histone deacetylase inhibitors such as sodium butyrate.

Enzyme Numbers (IUBMB) for HACD3 Gene

Gene Ontology (GO) - Molecular Function for HACD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS 10747961
GO:0005515 protein binding IPI 18160438
GO:0016829 lyase activity --
GO:0018812 3-hydroxyacyl-CoA dehydratase activity IDA 18554506
GO:0019899 enzyme binding IDA 18554506
genes like me logo Genes that share ontologies with HACD3: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HACD3 Gene

Localization for HACD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HACD3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for HACD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 18554506
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HACD3: view

Pathways for HACD3 Gene

SuperPathways for HACD3 Gene

No Data Available

UniProtKB/Swiss-Prot Q9P035-HACD3_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for HACD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
GO:0007254 JNK cascade --
GO:0007257 activation of JUN kinase activity TAS 10747961
GO:0007264 small GTPase mediated signal transduction TAS 10747961
genes like me logo Genes that share ontologies with HACD3: view

No data available for Pathways by source for HACD3 Gene

Transcripts for HACD3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HACD3 Gene

No ASD Table

Relevant External Links for HACD3 Gene

GeneLoc Exon Structure for
HACD3
ECgene alternative splicing isoforms for
HACD3

Expression for HACD3 Gene

mRNA expression in normal human tissues for HACD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HACD3 Gene

mRNA Expression by UniProt/SwissProt for HACD3 Gene

Q9P035-HACD3_HUMAN
Tissue specificity: Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes.
genes like me logo Genes that share expressions with HACD3: view

Orthologs for HACD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HACD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTPLAD1 36
  • 99.72 (n)
  • 100 (a)
PTPLAD1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PTPLAD1 36
  • 90.61 (n)
  • 92.82 (a)
PTPLAD1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPLAD1 36
  • 91.9 (n)
  • 94.2 (a)
PTPLAD1 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptplad1 36
  • 88.12 (n)
  • 91.16 (a)
Ptplad1 16
Ptplad1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PTPLAD1 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPLAD1 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptplad1 36
  • 88.21 (n)
  • 91.44 (a)
chicken
(Gallus gallus)
Aves PTPLAD1 36
  • 71.38 (n)
  • 68.98 (a)
PTPLAD1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPLAD1 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptplad1 36
  • 66.67 (n)
  • 68.17 (a)
Str.697 36
zebrafish
(Danio rerio)
Actinopterygii ptplad1 36
  • 66.67 (n)
  • 67.79 (a)
ptplad1 37
  • 67 (a)
OneToOne
zgc63632 36
fruit fly
(Drosophila melanogaster)
Insecta CG9267 36
  • 46.87 (n)
  • 36.36 (a)
CG9267 37
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHS1 37
  • 24 (a)
OneToMany
SBA1 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3155 37
  • 30 (a)
OneToMany
Species with no ortholog for HACD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HACD3 Gene

ENSEMBL:
Gene Tree for HACD3 (if available)
TreeFam:
Gene Tree for HACD3 (if available)

Paralogs for HACD3 Gene

Paralogs for HACD3 Gene

Pseudogenes.org Pseudogenes for HACD3 Gene

genes like me logo Genes that share paralogs with HACD3: view

Variants for HACD3 Gene

Sequence variations from dbSNP and Humsavar for HACD3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs12333 -- 65,576,934(+) ACATA(C/T)TTTAC utr-variant-3-prime
rs171290 -- 65,543,746(-) tttga(A/G)gatac intron-variant
rs189518 -- 65,545,106(-) ggtac(A/G)gtcaa intron-variant
rs189519 -- 65,532,857(-) ACTCA(C/T)CTTTG intron-variant
rs240749 -- 65,536,315(-) tgcca(C/T)aaaac intron-variant

Relevant External Links for HACD3 Gene

HapMap Linkage Disequilibrium report
HACD3

No data available for Structural Variations from Database of Genomic Variants (DGV) for HACD3 Gene

Disorders for HACD3 Gene

No disorders were found for HACD3 Gene.

No data available for UniProtKB/Swiss-Prot for HACD3 Gene

Publications for HACD3 Gene

  1. B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts. (PMID: 10747961) Courilleau D. … Mester J. (J. Biol. Chem. 2000) 2 3 4 23
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis. (PMID: 18554506) Ikeda M. … Kihara A. (FEBS Lett. 2008) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Human B-ind1 gene promoter: cloning and regulation by histone deacetylase inhibitors. (PMID: 16516406) Sabbah M. … Redeuilh G. (Gene 2006) 3 4

Products for HACD3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HACD3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HACD3
    • Block miRNA regulation of HACD3 using miScript Target Protectors

    Sources for HACD3 Gene

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