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Aliases for HACD3 Gene

Aliases for HACD3 Gene

  • 3-Hydroxyacyl-CoA Dehydratase 3 2 3 4 5
  • Protein-Tyrosine Phosphatase-Like A Domain-Containing Protein 1 3 4
  • Protein Tyrosine Phosphatase-Like A Domain Containing 1 2 3
  • Butyrate-Induced Protein 1 3 4
  • PTPLAD1 3 4
  • B-IND1 3 4
  • BIND1 3 4
  • Very-Long-Chain (3R)-3-Hydroxyacyl-[Acyl-Carrier Protein] Dehydratase 3 3
  • Very-Long-Chain (3R)-3-Hydroxyacyl-CoA Dehydratase 3 2
  • Protein Tyrosine Phosphatase-Like Protein PTPLAD1 3
  • Butyrate-Induced Transcript 1 3
  • EC 4.2.1.134 4
  • HSPC121 3
  • HB-Ind1 4

External Ids for HACD3 Gene

Previous HGNC Symbols for HACD3 Gene

  • PTPLAD1

Summaries for HACD3 Gene

GeneCards Summary for HACD3 Gene

HACD3 (3-Hydroxyacyl-CoA Dehydratase 3) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include enzyme binding and lyase activity. An important paralog of this gene is HACD4.

UniProtKB/Swiss-Prot for HACD3 Gene

  • Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).

Gene Wiki entry for HACD3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HACD3 Gene

Genomics for HACD3 Gene

Regulatory Elements for HACD3 Gene

Enhancers for HACD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HACD3 on UCSC Golden Path with GeneCards custom track

Promoters for HACD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HACD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HACD3 Gene

Chromosome:
15
Start:
65,530,418 bp from pter
End:
65,578,355 bp from pter
Size:
47,938 bases
Orientation:
Plus strand

Genomic View for HACD3 Gene

Genes around HACD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HACD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HACD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HACD3 Gene

Proteins for HACD3 Gene

  • Protein details for HACD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P035-HACD3_HUMAN
    Recommended name:
    Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
    Protein Accession:
    Q9P035
    Secondary Accessions:
    • A0PJA1
    • B4DRF4
    • Q280Z3
    • Q6PD63
    • Q8IUI5
    • Q8NC86
    • Q8NCB1
    • Q96T12
    • Q9NQA7

    Protein attributes for HACD3 Gene

    Size:
    362 amino acids
    Molecular mass:
    43160 Da
    Quaternary structure:
    • May interact with enzymes of the ELO family (including ELOVL1); with those enzymes that mediate condensation, the first of the four steps of the reaction cycle responsible for fatty acids elongation, may be part of a larger fatty acids elongase complex (PubMed:18554506). Interacts with RAC1 (PubMed:10747961). Associates with internalized insulin receptor/INSR complexes on Golgi/endosomal membranes; HACD3/PTPLAD1 together with ATIC and PRKAA2/AMPK2 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (PubMed:25687571).
    SequenceCaution:
    • Sequence=AAF29085.1; Type=Frameshift; Positions=356; Evidence={ECO:0000305}; Sequence=BAC11249.1; Type=Frameshift; Positions=359; Evidence={ECO:0000305};

    Alternative splice isoforms for HACD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HACD3 Gene

Proteomics data for HACD3 Gene at MOPED

Post-translational modifications for HACD3 Gene

  • Ubiquitination at Lys 98
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HACD3 Gene

Domains & Families for HACD3 Gene

Protein Domains for HACD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P035

UniProtKB/Swiss-Prot:

HACD3_HUMAN :
  • Contains 1 CS domain.
  • Belongs to the very long-chain fatty acids dehydratase HACD family.
Domain:
  • Contains 1 CS domain.
Family:
  • Belongs to the very long-chain fatty acids dehydratase HACD family.
genes like me logo Genes that share domains with HACD3: view

No data available for Gene Families for HACD3 Gene

Function for HACD3 Gene

Molecular function for HACD3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=49.5 uM for 3-hydroxypalmitoyl-CoA (at 37 degrees Celsius) {ECO:0000269 PubMed:18554506};
UniProtKB/Swiss-Prot CatalyticActivity:
A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).
UniProtKB/Swiss-Prot Induction:
By AKAP12 and histone deacetylase inhibitors such as sodium butyrate.

Enzyme Numbers (IUBMB) for HACD3 Gene

genes like me logo Genes that share phenotypes with HACD3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HACD3

miRNA for HACD3 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HACD3 Gene

Localization for HACD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HACD3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HACD3 Gene

Pathways & Interactions for HACD3 Gene

genes like me logo Genes that share pathways with HACD3: view

UniProtKB/Swiss-Prot Q9P035-HACD3_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for HACD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007257 activation of JUN kinase activity TAS 10747961
GO:0016601 Rac protein signal transduction NAS 10747961
GO:0030497 fatty acid elongation IDA 18554506
GO:0046726 positive regulation by virus of viral protein levels in host cell IMP 18160438
genes like me logo Genes that share ontologies with HACD3: view

No data available for SIGNOR curated interactions for HACD3 Gene

Drugs & Compounds for HACD3 Gene

(2) Additional Compounds for HACD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with HACD3: view

Transcripts for HACD3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HACD3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: - -

Relevant External Links for HACD3 Gene

GeneLoc Exon Structure for
HACD3
ECgene alternative splicing isoforms for
HACD3

Expression for HACD3 Gene

mRNA expression in normal human tissues for HACD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HACD3 Gene

This gene is overexpressed in Nasal epithelium (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HACD3 Gene



mRNA Expression by UniProt/SwissProt for HACD3 Gene

Q9P035-HACD3_HUMAN
Tissue specificity: Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes.
genes like me logo Genes that share expression patterns with HACD3: view

Protein tissue co-expression partners for HACD3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for HACD3 Gene

Orthologs for HACD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HACD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTPLAD1 35
  • 90.61 (n)
  • 92.82 (a)
PTPLAD1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTPLAD1 35
  • 91.9 (n)
  • 94.2 (a)
PTPLAD1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptplad1 35
  • 88.12 (n)
  • 91.16 (a)
Hacd3 16
Ptplad1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTPLAD1 35
  • 99.72 (n)
  • 100 (a)
PTPLAD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptplad1 35
  • 88.21 (n)
  • 91.44 (a)
oppossum
(Monodelphis domestica)
Mammalia PTPLAD1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTPLAD1 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTPLAD1 35
  • 71.38 (n)
  • 68.98 (a)
PTPLAD1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTPLAD1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ptplad1 35
  • 66.67 (n)
  • 68.17 (a)
Str.697 35
zebrafish
(Danio rerio)
Actinopterygii ptplad1 35
  • 66.67 (n)
  • 67.79 (a)
zgc63632 35
ptplad1 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9267 35
  • 46.87 (n)
  • 36.36 (a)
CG9267 36
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHS1 36
  • 24 (a)
OneToMany
SBA1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3155 36
  • 30 (a)
OneToMany
Species with no ortholog for HACD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HACD3 Gene

ENSEMBL:
Gene Tree for HACD3 (if available)
TreeFam:
Gene Tree for HACD3 (if available)

Paralogs for HACD3 Gene

Paralogs for HACD3 Gene

Pseudogenes.org Pseudogenes for HACD3 Gene

genes like me logo Genes that share paralogs with HACD3: view

Variants for HACD3 Gene

Sequence variations from dbSNP and Humsavar for HACD3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_037712 -
rs2279854 - 65,571,579(+) TTGAC(A/C)TGGAT reference, missense
rs12333 -- 65,576,934(+) ACATA(C/T)TTTAC utr-variant-3-prime
rs171290 -- 65,543,746(-) tttga(A/G)gatac intron-variant
rs189518 -- 65,545,106(-) ggtac(A/G)gtcaa intron-variant

Variation tolerance for HACD3 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for HACD3 Gene

Disorders for HACD3 Gene

Relevant External Links for HACD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HACD3

No disorders were found for HACD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HACD3 Gene

Publications for HACD3 Gene

  1. B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts. (PMID: 10747961) Courilleau D. … Mester J. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis. (PMID: 18554506) Ikeda M. … Kihara A. (FEBS Lett. 2008) 2 3
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. The last enzyme of the de novo purine synthesis pathway 5- aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. (PMID: 25687571) Boutchueng-Djidjou M. … Faure R.L. (Mol. Cell. Proteomics 2015) 3

Products for HACD3 Gene

Sources for HACD3 Gene

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