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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HABP4 Gene

protein-coding GIFtS: 52
GCID: GC09P099212

hyaluronan binding protein 4

Explore 2 diseases affiliated with
HABP4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hyaluronan Binding Protein 4¹ ²		Ki-1/57²
IHABP4¹ ² ³		Chromodomain Helicase DNA Binding Protein 3 Interacting Protein²
SERBP1L¹ ²		Intracellular Antigen Detected By Monoclonal Antibody Ki-1²
Ki-1/57 Intracellular Antigen² ³		Intracellular Hyaluronan-Binding Protein 4²
IHABP-4² ³

External Ids:	HGNC: 17062¹	Entrez Gene: 22927²	Ensembl: ENSG00000130956⁷	UniProtKB: Q5JVS0³

Export aliases for HABP4 gene to outside databases

Previous GC identifers: GC09P090026 GC09P090956 GC09P092669 GC09P094592 GC09P096292 GC09P098252 GC09P068823

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HABP4_HUMAN, Q5JVS0

Function: May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription

Gene Wiki entry for HABP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HABP4 gene promoter:
p53 p300 LUN-1 E4BP4 AP-2gamma FOXJ2 (long isoform) FOXJ2 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HABP4 promoter sequence

Search SABiosciences Chromatin IP Primers for HABP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HABP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3-q31 Ensembl cytogenetic band: 9q22.32 HGNC cytogenetic band: 9q22.3-q31

HABP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HABP4 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P099212: view genomic region (about GC identifiers)

Start:	99,212,414 bp from pter	End:	99,253,618 bp from pter
Size:	41,205 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HABP4_HUMAN, Q5JVS0 (See protein sequence)

Recommended Name: Intracellular hyaluronan-binding protein 4

Size: 413 amino acids; 45785 Da

Subunit: Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with GNB2L1. Interacts with

p53/TP53

Subcellular location: Cytoplasm. Nucleus. Note=Transported into the nuclear compartment in activated leukocytes

Miscellaneous: Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not

be relevant in vivo

Miscellaneous: The interaction with GNB2L1 is abolished upon activation of L540 tumor cells with PMA, which results in

phosphorylation and exit of HABP4 from the nucleus

Secondary accessions: O75804 Q8WV33 Q9NYJ2

Alternative splicing: 2 isoforms: Q5JVS0-1 Q5JVS0-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HABP4: NX_Q5JVS0

Post-translational modifications:

Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375 (Probable)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5JVS0

HABP4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055097.2

ENSEMBL proteins:

ENSP00000364400 ENSP00000364398

Reactome Protein details: Q5JVS0
Human Recombinant Protein Products:

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	Uscn Proteins for HABP4

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--
GO:0005829	cytosol	TAS	--
GO:0030017	sarcomere	ISS	--

HABP4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HABP4 for domains About GeneDecksing

1 InterPro domain/family:

IPR006861 HABP4_PAIRBP1-bd

Graphical View of Domain Structure for InterPro Entry Q5JVS0

ProtoNet protein and cluster: Q5JVS0

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HABP4_HUMAN, Q5JVS0

Function: May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription

miRNA Products:		OriGene 3'-UTR Clone: HABP4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HABP4
		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate HABP4 (see all 42):
		hsa-miR-579 hsa-miR-345 hsa-let-7d hsa-miR-106a hsa-miR-134 hsa-miR-301a hsa-miR-519a hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: HABP4 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HABP4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16169070

HABP4 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for HABP4

	Hemostasis
	Platelet degranulation
	Platelet activation, signaling and aggregation
	Response to elevated platelet cytosolic Ca2+

HABP4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HABP4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/46 Interacting proteins for HABP4 (Q5JVS0^{1, 2, 3} ENSP00000364398⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN2	Q16637²^,³, ENSP00000370119⁴	MINT-7041217 I2D: score=1 STRING: ENSP00000370119
C1QBP	Q07021²^,³, ENSP00000225698⁴	MINT-7041074 I2D: score=3 STRING: ENSP00000225698
CIRBP	Q14011²^,³, ENSP00000322887⁴	MINT-8194629 I2D: score=1 STRING: ENSP00000322887
COIL	P38432²^,³, ENSP00000240316⁴	MINT-7041203 I2D: score=1 STRING: ENSP00000240316
FXR1	P51114²^,³, ENSP00000350170⁴	MINT-8194614 I2D: score=1 STRING: ENSP00000350170

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	TAS	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0030168	platelet activation	TAS	--

HABP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HABP4
Search CenterWatch for drugs/clinical trials and news about HABP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HABP4 gene:

NM_014282.2

Unigene Cluster for HABP4:

Hyaluronan binding protein 4

Hs.494567 [show with all ESTs]

Unigene Representative Sequence: AK091242

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375251(uc010msh.3) ENST00000375249(uc010msg.3) ENST00000466976

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		hsa-miR-579 hsa-miR-345 hsa-let-7d hsa-miR-106a hsa-miR-134 hsa-miR-301a hsa-miR-519a hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: HABP4 3' UTR sequence

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Additional cDNA sequence:

AF241831.1 AK000610.1 AK025144.1 AK055161.1 AK091242.1 AK124836.1 BC018788.1 U77327.1

9 DOTS entries:

DT.317227 DT.99930684 DT.95083940 DT.95356898 DT.92469976 DT.40109657 DT.95083928 DT.121174336

DT.91927322

24/162 AceView cDNA sequences (see all 162):

BU736928 BM761762 CR613476 BM661599 AI912252 AI418660 BQ962055 BM842156

AI889924 AW515563 BX282384 CR607840 BM719882 BQ009655 AW169952 BM689626

BM709568 BG059636 N34326 BC018788 BE465800 AI015572 BF477812 CR613789

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HABP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGACTCTTA

About this image

HABP4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HABP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HABP4

SOURCE GeneReport for Unigene cluster: Hs.494567

UniProtKB/Swiss-Prot: HABP4_HUMAN, Q5JVS0

Tissue specificity: Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also

expressed in a variety of tumor cell lines and in activated but not resting leukocytes

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HABP4 gene from 9/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Habp4^{1 , 5}	hyaluronic acid binding protein 4^{1, 5}	85.56(n)¹ 86.62(a)¹		13 (33.26 cM)⁵ 56541¹ NM_019986.3¹ NP_064370.2¹ 64161866⁵
chicken (Gallus gallus)	Aves	HABP4¹	hyaluronan binding protein 4	66.67(n) 60.73(a)		395444 NM_204705.1 NP_990036.1
lizard (Anolis carolinensis)	Reptilia	HABP4⁶	--	59(a)	1 ↔ 1	2(39957374-39975216)
African clawed frog (Xenopus laevis)	Amphibia	BC059961.1²	--	76.22(n)		BC059961.1
zebrafish (Danio rerio)	Actinopterygii	zgc:103482¹	zgc:103482	57.11(n) 53.96(a)		450001 NM_001006022.1 NP_001006022.1
fruit fly (Drosophila melanogaster)	Insecta	CG41503⁶ vig2⁶ (see all 3)	vig2 (see all 3)	21(a) 19(a) (see all 3)	many ↔ many many ↔ many (see all 3)	YHet(305269-307004) 3R(20949095-20951341)
worm (Caenorhabditis elegans)	Secernentea	vig-1⁶	VIG (Drosophila Vasa Intronic Gene) ortholog famil...	19(a)	1 → many	II(1321042-1323094)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G17520⁶ AT5G47210⁶ (see all 3)	hyaluronan / mRNA binding-like protein (see all 3)	17(a) 17(a) (see all 3)	many ↔ many many ↔ many (see all 3)	4(9771297-9773592) 5(19169022-19171263)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	plasminogen activator inhibitor 1 RNA-binding prot... hyaluronan/mRNA binding family domain containing p... (see all 5)	19(a) 19(a) (see all 5)	many ↔ many many ↔ many (see all 5)	1(30094375-30097752) 5(29293328-29296564)

ENSEMBL Gene Tree for HABP4 (if available)
TreeFam Gene Tree for HABP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HABP4 gene

SERBP1²

2 SIMAP similar genes for HABP4 using alignment to 1 protein entry: HABP4_HUMAN:

DKFZp686P17171 SERBP1

HABP4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35109507^1,2	C	--	68844329(+)	`ATTTC-/TTTTTT`	1	--	int¹		2		NA CSA	4
rs150339161^1,2		--	99210510(+)	`TTGTGA/CATAGT`	1	--	us2k¹		0	--	--	--	--
rs138040118^1,2		--	99210523(+)	`TGCTAC/TGAATA`	1	--	us2k¹		0	--	--	--	--
rs142425745^1,2		--	99210529(+)	`GAATAC/TTCATG`	1	--	us2k¹		0	--	--	--	--
rs7870106^1,2	C,F,A,H,	--	99210584(+)	`AAAGCG/ATAGGC`	1	--	us2k¹		31		NA NS EA WA CSA	2913
rs59933699^1,2	C,	--	99210870(+)	`CTCTAA/TCTGGA`	1	--	us2k¹		2		WA	120
rs144659712^1,2		--	99210931(+)	`CCTTAC/TATCAT`	1	--	us2k¹		0	--	--	--	--
rs138621408^1,2		--	99211099(+)	`AGAAGC/GGGGGG`	1	--	us2k¹		0	--	--	--	--
rs111516833^1,2	C,	--	99211100(+)	`GAAGGG/CGGGGA`	1	--	us2k¹		1		WA	2
rs149514960^1,2		--	99211220(+)	`AGGAA-/TTGGAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HABP4 (99212414 - 99253618 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HABP4
1 Indel: 65465

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HABP4

DNA2.0 Custom Variant and Variant Library Synthesis for HABP4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HABP4 for disorders About GeneDecksing

2 diseases for HABP4: About MalaCards

hodgkin's lymphoma colon cancer

Human Genome Epidemiology (HuGE) Navigator: HABP4 (1 document)

Export disorders for HABP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HABP4 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with HABP4)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization of a novel intracellular hyaluronan- binding protein. (PubMed id 10887182)^{1, 2, 3, 9} Huang L.... Toole B.P. (2000)
Characterization, mapping and partial cDNA sequence of the 57-kD intracellular Ki-1 antigen. (PubMed id 9523163)^{1, 2, 3} Kobarg J....Hansen H.P. (1997)
Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. (PubMed id 14699138)^{1, 2, 9} Nery F.C.... Kobarg J. (2004)
Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins. (PubMed id 16455055)^{1, 2} Nery F.C.... Kobarg J. (2006)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PubMed id 12505151)^{1, 2} Lemos T.A.... Kobarg J. (2003)
Evidence for the association of the human regulatory protein Ki-1/57 with the translational machinery. (PubMed id 21771594)¹ GonAsalves K.d.e. .A....Kobarg J. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
From protein interaction profile to functional assign ment: the human protein Ki-1/57 is associated with pre-mRNA splicing events. (PubMed id 20436279)¹ Bressan G.C. and Kobarg J. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 22927	HGNC: 17062	AceView: HABP4	Ensembl:ENSG00000130956	euGenes: HUgn22927
ECgene: HABP4	H-InvDB: HABP4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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hyaluronan binding protein 4

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hyaluronan binding protein 4

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