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Aliases for HABP4 Gene

Aliases for HABP4 Gene

  • Hyaluronan Binding Protein 4 2 3 5
  • Ki-1/57 Intracellular Antigen 3 4
  • IHABP-4 3 4
  • IHABP4 3 4
  • Chromodomain Helicase DNA Binding Protein 3 Interacting Protein 3
  • Intracellular Antigen Detected By Monoclonal Antibody Ki-1 3
  • Ki-1/57 3
  • SERBP1L 3

External Ids for HABP4 Gene

Previous GeneCards Identifiers for HABP4 Gene

  • GC09P090026
  • GC09P090956
  • GC09P092669
  • GC09P094592
  • GC09P096292
  • GC09P098252
  • GC09P099212
  • GC09P068823

Summaries for HABP4 Gene

GeneCards Summary for HABP4 Gene

HABP4 (Hyaluronan Binding Protein 4) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation. An important paralog of this gene is SERBP1.

UniProtKB/Swiss-Prot for HABP4 Gene

  • May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.

Gene Wiki entry for HABP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HABP4 Gene

Genomics for HABP4 Gene

Regulatory Elements for HABP4 Gene

Enhancers for HABP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HABP4 on UCSC Golden Path with GeneCards custom track

Promoters for HABP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HABP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for HABP4 Gene

96,450,155 bp from pter
96,491,336 bp from pter
41,182 bases
Plus strand

Genomic View for HABP4 Gene

Genes around HABP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HABP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HABP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HABP4 Gene

Proteins for HABP4 Gene

  • Protein details for HABP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intracellular hyaluronan-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • O75804
    • Q8WV33
    • Q9NYJ2

    Protein attributes for HABP4 Gene

    413 amino acids
    Molecular mass:
    45785 Da
    Quaternary structure:
    • Interacts with SPIN1 (By similarity). Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with RACK1. Interacts with p53/TP53.
    • Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo.
    • The interaction with RACK1 is abolished upon activation of L540 tumor cells with PMA, which results in phosphorylation and exit of HABP4 from the nucleus.

    Alternative splice isoforms for HABP4 Gene


neXtProt entry for HABP4 Gene

Proteomics data for HABP4 Gene at MOPED

Post-translational modifications for HABP4 Gene

  • Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HABP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HABP4 Gene

Domains & Families for HABP4 Gene

Protein Domains for HABP4 Gene


Suggested Antigen Peptide Sequences for HABP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HABP4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HABP4 Gene

Function for HABP4 Gene

Molecular function for HABP4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.

Phenotypes for HABP4 Gene

genes like me logo Genes that share phenotypes with HABP4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HABP4 Gene

Localization for HABP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HABP4 Gene

Cytoplasm. Nucleus. Note=Transported into the nuclear compartment in activated leukocytes.

Subcellular locations from

Jensen Localization Image for HABP4 Gene COMPARTMENTS Subcellular localization image for HABP4 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
GO:0005829 cytosol TAS --
GO:0030017 sarcomere IEA,ISS --
genes like me logo Genes that share ontologies with HABP4: view

Pathways & Interactions for HABP4 Gene

genes like me logo Genes that share pathways with HABP4: view

Gene Ontology (GO) - Biological Process for HABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030168 platelet activation TAS --
GO:0043392 negative regulation of DNA binding IDA 15862299
genes like me logo Genes that share ontologies with HABP4: view

No data available for SIGNOR curated interactions for HABP4 Gene

Drugs & Compounds for HABP4 Gene

(1) Drugs for HABP4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma Target, binder 411
genes like me logo Genes that share compounds with HABP4: view

Transcripts for HABP4 Gene

Unigene Clusters for HABP4 Gene

Hyaluronan binding protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HABP4 Gene

No ASD Table

Relevant External Links for HABP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HABP4 Gene

mRNA expression in normal human tissues for HABP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HABP4 Gene

This gene is overexpressed in Amniocyte (23.0), Pancreatic juice (9.9), and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HABP4 Gene

SOURCE GeneReport for Unigene cluster for HABP4 Gene Hs.494567

mRNA Expression by UniProt/SwissProt for HABP4 Gene

Tissue specificity: Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes.
genes like me logo Genes that share expression patterns with HABP4: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for HABP4 Gene

Orthologs for HABP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HABP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HABP4 35
  • 88.7 (n)
  • 89.35 (a)
HABP4 36
  • 89 (a)
(Canis familiaris)
Mammalia HABP4 35
  • 88.51 (n)
  • 89.66 (a)
HABP4 36
  • 87 (a)
(Mus musculus)
Mammalia Habp4 35
  • 85 (n)
  • 85.4 (a)
Habp4 16
Habp4 36
  • 84 (a)
(Pan troglodytes)
Mammalia HABP4 35
  • 99.6 (n)
  • 99.52 (a)
HABP4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Habp4 35
  • 85.24 (n)
  • 86.37 (a)
(Monodelphis domestica)
Mammalia HABP4 36
  • 60 (a)
(Gallus gallus)
Aves HABP4 35
  • 63.56 (n)
  • 55.08 (a)
HABP4 36
  • 54 (a)
(Anolis carolinensis)
Reptilia HABP4 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia habp4 35
  • 55.59 (n)
  • 47.48 (a)
(Danio rerio)
Actinopterygii zgc:103482 35
  • 59.97 (n)
  • 58.76 (a)
HABP4 36
  • 47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8747 35
fruit fly
(Drosophila melanogaster)
Insecta CG41503 36
  • 23 (a)
vig 36
  • 20 (a)
vig2 36
  • 21 (a)
Species with no ortholog for HABP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HABP4 Gene

Gene Tree for HABP4 (if available)
Gene Tree for HABP4 (if available)

Paralogs for HABP4 Gene

Paralogs for HABP4 Gene

(2) SIMAP similar genes for HABP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HABP4: view

Variants for HABP4 Gene

Sequence variations from dbSNP and Humsavar for HABP4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs754559 -- 96,450,627(+) GCGCC(C/G)GGTAC upstream-variant-2KB, reference, synonymous-codon
rs754560 -- 96,450,648(+) CGGGG(G/T)TAGCG intron-variant, upstream-variant-2KB
rs754561 -- 96,450,709(+) GAGGA(A/G)GGGCC intron-variant, upstream-variant-2KB
rs1114238 -- 96,483,779(+) gccta(G/T)gtttt intron-variant
rs7847457 -- 96,481,508(+) gaggc(A/C)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HABP4 Gene

Variant ID Type Subtype PubMed ID
nsv893603 CNV Gain 21882294
nsv824998 CNV Gain 20364138
nsv893604 CNV Gain 21882294
esv22781 CNV Loss 19812545
esv2669547 CNV Deletion 23128226

Variation tolerance for HABP4 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HABP4 Gene

Disorders for HABP4 Gene

Relevant External Links for HABP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HABP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HABP4 Gene

Publications for HABP4 Gene

  1. Molecular characterization of a novel intracellular hyaluronan- binding protein. (PMID: 10887182) Huang L. … Toole B.P. (J. Biol. Chem. 2000) 2 3 4 23 25 67
  2. Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. (PMID: 14699138) Nery F.C. … Kobarg J. (J. Biol. Chem. 2004) 3 23
  3. Characterization, mapping and partial cDNA sequence of the 57-kD intracellular Ki-1 antigen. (PMID: 9523163) Kobarg J. … Hansen H.P. (Exp. Clin. Immunogenet. 1997) 2 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for HABP4 Gene

Sources for HABP4 Gene