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Aliases for HABP4 Gene

Aliases for HABP4 Gene

  • Hyaluronan Binding Protein 4 2 3 5
  • Ki-1/57 Intracellular Antigen 3 4
  • IHABP-4 3 4
  • IHABP4 3 4
  • Chromodomain Helicase DNA Binding Protein 3 Interacting Protein 3
  • Intracellular Antigen Detected By Monoclonal Antibody Ki-1 3
  • Intracellular Hyaluronan-Binding Protein 4 3
  • Ki-1/57 3
  • SERBP1L 3

External Ids for HABP4 Gene

Previous GeneCards Identifiers for HABP4 Gene

  • GC09P090026
  • GC09P090956
  • GC09P092669
  • GC09P094592
  • GC09P096292
  • GC09P098252
  • GC09P099212
  • GC09P068823

Summaries for HABP4 Gene

GeneCards Summary for HABP4 Gene

HABP4 (Hyaluronan Binding Protein 4) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is SERBP1.

UniProtKB/Swiss-Prot for HABP4 Gene

  • May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.

Gene Wiki entry for HABP4 Gene

Additional gene information for HABP4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HABP4 Gene

Genomics for HABP4 Gene

Regulatory Elements for HABP4 Gene

Enhancers for HABP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H096449 1.3 FANTOM5 ENCODE 14.3 +0.5 459 2.3 PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 GLIS2 ZNF143 FOS ATF7 HABP4 NUTM2G ERCC6L2 ENSG00000271155 ANKRD18CP CDC14B ZNF510 LOC105376163
GH09H096416 1.8 FANTOM5 ENCODE dbSUPER 10.2 -31.2 -31178 5.4 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 ERCC6L2 ENSG00000271155 ZNF322P1 ZNF782 EIF4BP3 ENSG00000254633 NUTM2G MFSD14C LOC441454 LOC100421693
GH09H096485 1.2 Ensembl ENCODE dbSUPER 12.9 +36.7 36681 2.6 TFAP4 ATF1 ZNF316 POLR2A ATF7 CREM NFIA TEAD1 ATF2 NR2F2 HABP4 LOC105376163
GH09H096490 1.2 ENCODE dbSUPER 12.9 +41.9 41854 2.4 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 PAF1 SP5 MXD4 PPARG HABP4 LOC105376163
GH09H096389 1.5 Ensembl ENCODE dbSUPER 8.6 -58.8 -58762 2.8 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 ZHX2 NFYC REST ZNF367 HABP4 SLC35D2 LOC100421693
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HABP4 on UCSC Golden Path with GeneCards custom track

Promoters for HABP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000238411 345 1801 PKNOX1 ATF1 FOXA2 ARID4B SIN3A GLIS2 ZNF143 FOS ATF7 SP3

Genomic Locations for HABP4 Gene

Genomic Locations for HABP4 Gene
41,182 bases
Plus strand

Genomic View for HABP4 Gene

Genes around HABP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HABP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HABP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HABP4 Gene

Proteins for HABP4 Gene

  • Protein details for HABP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intracellular hyaluronan-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • O75804
    • Q8WV33
    • Q9NYJ2

    Protein attributes for HABP4 Gene

    413 amino acids
    Molecular mass:
    45785 Da
    Quaternary structure:
    • Interacts with SPIN1 (By similarity). Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with RACK1. Interacts with p53/TP53.
    • Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo.
    • The interaction with RACK1 is abolished upon activation of L540 tumor cells with PMA, which results in phosphorylation and exit of HABP4 from the nucleus.

    Alternative splice isoforms for HABP4 Gene


neXtProt entry for HABP4 Gene

Post-translational modifications for HABP4 Gene

  • Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HABP4 Gene

No data available for DME Specific Peptides for HABP4 Gene

Domains & Families for HABP4 Gene

Gene Families for HABP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HABP4 Gene


Suggested Antigen Peptide Sequences for HABP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HABP4: view

No data available for UniProtKB/Swiss-Prot for HABP4 Gene

Function for HABP4 Gene

Molecular function for HABP4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.

Phenotypes From GWAS Catalog for HABP4 Gene

Gene Ontology (GO) - Molecular Function for HABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15862299
genes like me logo Genes that share ontologies with HABP4: view

Phenotypes for HABP4 Gene

genes like me logo Genes that share phenotypes with HABP4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HABP4 Gene

Localization for HABP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HABP4 Gene

Cytoplasm. Nucleus. Note=Transported into the nuclear compartment in activated leukocytes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HABP4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 19523114
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with HABP4: view

Pathways & Interactions for HABP4 Gene

genes like me logo Genes that share pathways with HABP4: view

Gene Ontology (GO) - Biological Process for HABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0033120 positive regulation of RNA splicing IMP 19523114
GO:0043392 negative regulation of DNA binding IDA 15862299
genes like me logo Genes that share ontologies with HABP4: view

No data available for SIGNOR curated interactions for HABP4 Gene

Drugs & Compounds for HABP4 Gene

(1) Drugs for HABP4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target, binder 503
genes like me logo Genes that share compounds with HABP4: view

Transcripts for HABP4 Gene

Unigene Clusters for HABP4 Gene

Hyaluronan binding protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HABP4 Gene

No ASD Table

Relevant External Links for HABP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HABP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HABP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HABP4 Gene

This gene is overexpressed in Amniocyte (23.0), Pancreatic juice (9.9), and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HABP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of HABP4 Gene:


SOURCE GeneReport for Unigene cluster for HABP4 Gene:


mRNA Expression by UniProt/SwissProt for HABP4 Gene:

Tissue specificity: Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes.

Evidence on tissue expression from TISSUES for HABP4 Gene

  • Liver(4.1)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with HABP4: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HABP4 Gene

Orthologs for HABP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HABP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HABP4 33 34
  • 99.6 (n)
(Bos Taurus)
Mammalia HABP4 33 34
  • 88.7 (n)
(Canis familiaris)
Mammalia HABP4 33 34
  • 88.51 (n)
(Rattus norvegicus)
Mammalia Habp4 33
  • 85.24 (n)
(Mus musculus)
Mammalia Habp4 33 16 34
  • 85 (n)
(Monodelphis domestica)
Mammalia HABP4 34
  • 60 (a)
(Gallus gallus)
Aves HABP4 33 34
  • 63.56 (n)
(Anolis carolinensis)
Reptilia HABP4 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia habp4 33
  • 55.59 (n)
(Danio rerio)
Actinopterygii zgc:103482 33
  • 59.97 (n)
HABP4 34
  • 47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8747 33
fruit fly
(Drosophila melanogaster)
Insecta CG41503 34
  • 23 (a)
vig2 34
  • 21 (a)
vig 34
  • 20 (a)
Species where no ortholog for HABP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HABP4 Gene

Gene Tree for HABP4 (if available)
Gene Tree for HABP4 (if available)

Paralogs for HABP4 Gene

Paralogs for HABP4 Gene

(2) SIMAP similar genes for HABP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HABP4: view

Variants for HABP4 Gene

Sequence variations from dbSNP and Humsavar for HABP4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000106559 -- 96,491,192(+) TCTGC(C/T)TGTTG nc-transcript-variant, utr-variant-3-prime
rs1000153283 -- 96,448,291(+) CTTTT(G/T)GGTAG upstream-variant-2KB
rs1000185001 -- 96,468,632(+) AAGCA(A/G)TTCAC intron-variant
rs1000205945 -- 96,457,822(+) AAGAT(A/T)AAACA intron-variant
rs1000329713 -- 96,461,641(+) GCTGG(C/G/T)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HABP4 Gene

Variant ID Type Subtype PubMed ID
nsv950906 CNV deletion 24416366
nsv824998 CNV gain 20364138
nsv614933 CNV loss 21841781
nsv614930 CNV loss 21841781
nsv614924 CNV loss 21841781
nsv472681 CNV novel sequence insertion 20440878
nsv1147999 OTHER inversion 26484159
esv3621165 CNV loss 21293372
esv3545168 CNV deletion 23714750
esv2669547 CNV deletion 23128226
esv22781 CNV loss 19812545
dgv12804n54 CNV loss 21841781
dgv12803n54 CNV loss 21841781

Variation tolerance for HABP4 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HABP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HABP4 Gene

Disorders for HABP4 Gene

Relevant External Links for HABP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HABP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HABP4 Gene

Publications for HABP4 Gene

  1. Molecular characterization of a novel intracellular hyaluronan-binding protein. (PMID: 10887182) Huang L … Toole BP (The Journal of biological chemistry 2000) 2 3 4 22 60
  2. Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. (PMID: 14699138) Nery FC … Kobarg J (The Journal of biological chemistry 2004) 3 4 22 60
  3. Characterization, mapping and partial cDNA sequence of the 57-kD intracellular Ki-1 antigen. (PMID: 9523163) Kobarg J … Hansen HP (Experimental and clinical immunogenetics 1997) 2 3 4 60
  4. Confirmation of linkage to and localization of familial colon cancer risk haplotype on chromosome 9q22. (PMID: 20551049) Gray-McGuire C … Wiesner GL (Cancer research 2010) 3 45 60
  5. Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins. (PMID: 16455055) Nery FC … Kobarg J (Biochemical and biophysical research communications 2006) 3 4 60

Products for HABP4 Gene

Sources for HABP4 Gene

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