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Aliases for HABP4 Gene

Aliases for HABP4 Gene

  • Hyaluronan Binding Protein 4 2 3
  • Ki-1/57 Intracellular Antigen 3 4
  • IHABP-4 3 4
  • IHABP4 3 4
  • Chromodomain Helicase DNA Binding Protein 3 Interacting Protein 3
  • Intracellular Antigen Detected By Monoclonal Antibody Ki-1 3
  • Intracellular Hyaluronan-Binding Protein 4 3
  • Ki-1/57 3
  • SERBP1L 3

External Ids for HABP4 Gene

Previous GeneCards Identifiers for HABP4 Gene

  • GC09P090026
  • GC09P090956
  • GC09P092669
  • GC09P094592
  • GC09P096292
  • GC09P098252
  • GC09P099212
  • GC09P068823

Summaries for HABP4 Gene

GeneCards Summary for HABP4 Gene

HABP4 (Hyaluronan Binding Protein 4) is a Protein Coding gene. Among its related pathways are Hemostasis and Hemostasis. An important paralog of this gene is SERBP1.

UniProtKB/Swiss-Prot for HABP4 Gene

  • May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.

Gene Wiki entry for HABP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HABP4 Gene

Genomics for HABP4 Gene

Regulatory Elements for HABP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HABP4 Gene

96,450,155 bp from pter
96,491,336 bp from pter
41,182 bases
Plus strand

Genomic View for HABP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HABP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HABP4 Gene

Proteins for HABP4 Gene

  • Protein details for HABP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intracellular hyaluronan-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • O75804
    • Q8WV33
    • Q9NYJ2

    Protein attributes for HABP4 Gene

    413 amino acids
    Molecular mass:
    45785 Da
    Quaternary structure:
    • Interacts with SPIN1 (By similarity). Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with GNB2L1. Interacts with p53/TP53.
    • Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo
    • The interaction with GNB2L1 is abolished upon activation of L540 tumor cells with PMA, which results in phosphorylation and exit of HABP4 from the nucleus.

    Alternative splice isoforms for HABP4 Gene


neXtProt entry for HABP4 Gene

Proteomics data for HABP4 Gene at MOPED

Post-translational modifications for HABP4 Gene

  • Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HABP4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HABP4 Gene

Domains for HABP4 Gene

Protein Domains for HABP4 Gene


Suggested Antigen Peptide Sequences for HABP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HABP4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HABP4 Gene

Function for HABP4 Gene

Molecular function for HABP4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.

Gene Ontology (GO) - Molecular Function for HABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15862299
genes like me logo Genes that share ontologies with HABP4: view

Animal Model Products

miRNA for HABP4 Gene

miRTarBase miRNAs that target HABP4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HABP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for HABP4 Gene

Localization for HABP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HABP4 Gene

Cytoplasm. Nucleus. Note=Transported into the nuclear compartment in activated leukocytes.

Subcellular locations from

Jensen Localization Image for HABP4 Gene COMPARTMENTS Subcellular localization image for HABP4 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 4
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HABP4: view

Pathways for HABP4 Gene

genes like me logo Genes that share pathways with HABP4: view

Gene Ontology (GO) - Biological Process for HABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with HABP4: view

Drugs for HABP4 Gene

(1) Drugbank Compounds for HABP4 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • Hyaluronate
9067-32-7 Target binder approved
genes like me logo Genes that share compounds with HABP4: view

Transcripts for HABP4 Gene

mRNA/cDNA for HABP4 Gene

Unigene Clusters for HABP4 Gene

Hyaluronan binding protein 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HABP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HABP4 Gene

No ASD Table

Relevant External Links for HABP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HABP4 Gene

mRNA expression in normal human tissues for HABP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for HABP4 Gene

This gene is overexpressed in Amniocyte (23.0), Pancreatic juice (9.9), and Fetal Brain (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HABP4 Gene

SOURCE GeneReport for Unigene cluster for HABP4 Gene Hs.494567

mRNA Expression by UniProt/SwissProt for HABP4 Gene

Tissue specificity: Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes.
genes like me logo Genes that share expressions with HABP4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for HABP4 Gene

Orthologs for HABP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HABP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HABP4 35
  • 88.7 (n)
  • 89.35 (a)
HABP4 36
  • 89 (a)
(Canis familiaris)
Mammalia HABP4 35
  • 88.51 (n)
  • 89.66 (a)
HABP4 36
  • 87 (a)
(Mus musculus)
Mammalia Habp4 35
  • 85 (n)
  • 85.4 (a)
Habp4 16
Habp4 36
  • 84 (a)
(Pan troglodytes)
Mammalia HABP4 35
  • 99.6 (n)
  • 99.52 (a)
HABP4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Habp4 35
  • 85.24 (n)
  • 86.37 (a)
(Monodelphis domestica)
Mammalia HABP4 36
  • 60 (a)
(Gallus gallus)
Aves HABP4 35
  • 63.56 (n)
  • 55.08 (a)
HABP4 36
  • 54 (a)
(Anolis carolinensis)
Reptilia HABP4 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia habp4 35
  • 55.59 (n)
  • 47.48 (a)
(Danio rerio)
Actinopterygii zgc:103482 35
  • 59.97 (n)
  • 58.76 (a)
HABP4 36
  • 47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8747 35
fruit fly
(Drosophila melanogaster)
Insecta CG41503 36
  • 23 (a)
vig 36
  • 20 (a)
vig2 36
  • 21 (a)
Species with no ortholog for HABP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HABP4 Gene

Gene Tree for HABP4 (if available)
Gene Tree for HABP4 (if available)

Paralogs for HABP4 Gene

Paralogs for HABP4 Gene

(2) SIMAP similar genes for HABP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HABP4: view

Variants for HABP4 Gene

Sequence variations from dbSNP and Humsavar for HABP4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs75813893 -- 96,451,617(+) AACGT(C/T)TCAGG intron-variant
rs76426553 -- 96,452,755(+) GATAA(A/G)AAGCA intron-variant
rs77231970 -- 96,462,922(+) GTCTG(A/G)AAAAA intron-variant
rs78346598 -- 96,464,657(+) AGGAA(A/G)ATTGG intron-variant
rs78699460 -- 96,452,245(+) AAAAA(A/T)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HABP4 Gene

Variant ID Type Subtype PubMed ID
nsv893603 CNV Gain 21882294
nsv824998 CNV Gain 20364138
nsv893604 CNV Gain 21882294
esv22781 CNV Loss 19812545
esv2669547 CNV Deletion 23128226

Relevant External Links for HABP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HABP4 Gene

Disorders for HABP4 Gene

Relevant External Links for HABP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for HABP4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HABP4 Gene

Publications for HABP4 Gene

  1. Molecular characterization of a novel intracellular hyaluronan- binding protein. (PMID: 10887182) Huang L. … Toole B.P. (J. Biol. Chem. 2000) 2 3 4 23 25
  2. Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. (PMID: 14699138) Nery F.C. … Kobarg J. (J. Biol. Chem. 2004) 3 4 23
  3. Characterization, mapping and partial cDNA sequence of the 57-kD intracellular Ki-1 antigen. (PMID: 9523163) Kobarg J. … Hansen H.P. (Exp. Clin. Immunogenet. 1997) 2 3 4
  4. Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins. (PMID: 16455055) Nery F.C. … Kobarg J. (Biochem. Biophys. Res. Commun. 2006) 3 4
  5. Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PMID: 12505151) Lemos T.A. … Kobarg J. (FEBS Lett. 2003) 3 4

Products for HABP4 Gene

Sources for HABP4 Gene

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