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Aliases & Descriptions for HABP4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| IHABP4 1, 2, 3 | | Ki-1/57 2 | | MGC825 2 | | OTTHUMP00000021722 2 | | SERBP1L 1, 2 |
| | | Descriptions |
|---|
| Ki-1/57 intracellular antigen 3 | chromodomain helicase DNA binding protein 3 interacting protein 2 | | hyaluronan binding protein 4 2 | | intracellular antigen detected by monoclonal antibody Ki-1 2 | | intracellular hyaluronan-binding protein 2 |
|
| | Search outside databases for aliases for HABP4 genePrevious GC identifers: GC09P090026 GC09P090956 GC09P092669 GC09P094592 GC09P096292 |
Summaries for HABP4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: HABP4_HUMAN, Q5JVS0Function: May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcriptionGene Wiki entry for HABP4 |
Genomic Location for HABP4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HABP4 gene 
Entrez Gene cytogenetic band: 9q22.3-q31 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22.3-q31HABP4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P098252:
(about GC identifiers)
Start:
|
98,252,235 bp from pter |
End:
|
98,293,439 bp from pter |
Size:
|
41,205 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008470.18
| Proteins for HABP4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HABP4_HUMAN, Q5JVS0 (See
protein sequence)Recommended Name: Intracellular hyaluronan-binding protein 4 Size: 413 amino acids; 45785 Da
Subunit: Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with GNB2L1. Interacts with TP53/p53
Subcellular location: Cytoplasm. Nucleus. Note=Transported into the nuclear compartment in activated leukocytes
Miscellaneous: Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo
Miscellaneous: The interaction with GNB2L1 is abolished upon activation of L540 tumor cells with PMA, which results in phosphorylation and exit of HABP4 from the nucleus
Secondary accessions: O75804 Q8WV33 Q9NYJ2Alternative splicing: 2 isoforms: Q5JVS0-1 Q5JVS0-2 Post-translational modifications:
Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375 (Probable)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055097.2
ENSEMBL proteins: ENSP00000364398 ENSP00000364400
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HABP4: Assays for HABP4: | Protein
Domains/ Families for HABP4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q5JVS0
ProtoNet protein and cluster: Q5JVS0 | Gene Function for HABP4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014282
Applied Biosystems Silencer® siRNAs for HABP4
Sigma-Aldrich siRNA for HABP4  Sigma-Aldrich shRNA for HABP4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014282                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014282                                  untagged cDNA clone in CMV expression vector: NM_014282 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014282
UniProtKB/Swiss-Prot: HABP4_HUMAN, Q5JVS0Function: May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription | Pathways & Interactions for HABP4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for HABP4 
5/18 Interacting proteins for HABP4 (ENSP000003643983 Q5JVS02) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for HABP4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for HABP4
|
Transcripts for HABP4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014282
Sigma-Aldrich siRNA for HABP4  Sigma-Aldrich shRNA for HABP4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014282 REFSEQ mRNAs for HABP4 gene: NM_014282.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014282               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014282                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014282                                  untagged cDNA clone in CMV expression vector: NM_014282  Additional cDNA sequence: AF241831.1 AK000610.1 AK025144.1 AK055161.1 AK091242.1 AK124836.1 BC018788.1 CR596448.1 CR607840.1 CR613476.1 CR613789.1 U77327.1 9 DOTS entries: DT.317227 DT.99930684 DT.95083940 DT.95356898 DT.92469976 DT.40109657 DT.91927322 DT.95083928 DT.121174336 24/162 AceView cDNA sequences (see all 162
):AI015572 BM661599 N34326 AW515563 BQ009655 AI889924 BM719882 BU727478 CB158708 CR613476 BM761762 AI418660 BF477812 AA904204 CB159244 BF475746 BM689626 BG059636 AI912252 AA593631 BG760852 BU736928 BU734666 CR596448
highest scoring ESTs for HABP4:U77327 AA314750 AF241831 AI590092 AK000610 AK055161 AK091242 AL571960 AV751753 AW515563 Unigene Cluster for HABP4: Hyaluronan binding protein 4 Hs.494567 [show with all ESTs]Unigene Representative Sequence: AK091242
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000375249
ENST00000375251
|
Expression for HABP4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HABP4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HABP4
1 / 2 / 3 12 probe-sets matching HABP4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAGACTCTTA
SOURCE GeneReport for Unigene cluster: Hs.494567
Expression variation in blood from EXPOLDB for HABP4 UniProtKB/Swiss-Prot: HABP4_HUMAN, Q5JVS0Tissue specificity: Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes |
Orthologs for HABP4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HABP4 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for HABP4
ENSEMBL Gene Tree for HABP4 | Paralogs for HABP4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for HABP4 gene
- SERBP12
|
SNPs/Variants for HABP4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HABP4 (up to first 250kb)
|
Disorders & Mutations for HABP4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for HABP4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HABP4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for HABP4 gene (see all 16
):- Molecular characterization of a novel intracellular hyaluronan-binding protein. (PubMed id 10887182)1, 2, 3, 4 Huang L....Toole B.P. (2000)
- Characterization, mapping and partial cDNA sequence of the 57-kD intracellular Ki-1 antigen. (PubMed id 9523163)2, 3, 4 Kobarg J....Hansen H.P. (1997)
- Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. (PubMed id 14699138)1, 3, 4 Nery F.C.... Kobarg J. (2004)
- Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins. (PubMed id 16455055)3, 4 Nery F.C.... Kobarg J. (2006)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)3, 4 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PubMed id 12505151)3, 4 Lemos T.A.... Kobarg J. (2003)
- Human regulatory protein Ki-1/57 has characteristics of an intrinsically unstructured protein. (PubMed id 18788774)3 Bressan G.C....Kobarg J. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation. (PubMed id 16879614)3 Passos D.O....Kobarg J. (2006)
|
Search for HABP4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HABP4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HABP4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HABP4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HABP4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HABP4:

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Incremental update: 13 Oct 2009
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