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Aliases for HABP2 Gene

Aliases for HABP2 Gene

  • Hyaluronan Binding Protein 2 2 3 5
  • Hepatocyte Growth Factor Activator-Like Protein 3 4
  • Plasma Hyaluronan Binding Protein 2 3
  • Plasma Hyaluronan-Binding Protein 3 4
  • Factor Seven-Activating Protease 3 4
  • Factor VII-Activating Protease 3 4
  • Factor VII Activating Protein 2 3
  • HGFAL 3 4
  • FSAP 3 4
  • PHBP 3 4
  • Hyaluronic Acid Binding Protein 2 3
  • Hyaluronan-Binding Protein 2 2
  • EC 3.4.21.92 63
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • NMTC5 3
  • HABP 3

External Ids for HABP2 Gene

Previous GeneCards Identifiers for HABP2 Gene

  • GC10P114208
  • GC10P114546
  • GC10P115444
  • GC10P114977
  • GC10P115302
  • GC10P108937

Summaries for HABP2 Gene

Entrez Gene Summary for HABP2 Gene

  • This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for HABP2 Gene

HABP2 (Hyaluronan Binding Protein 2) is a Protein Coding gene. Diseases associated with HABP2 include thyroid cancer, nonmedullary, 5 and familial papillary or follicular thyroid carcinoma. GO annotations related to this gene include calcium ion binding and glycosaminoglycan binding. An important paralog of this gene is PLAT.

UniProtKB/Swiss-Prot for HABP2 Gene

  • Cleaves the alpha-chain at multiple sites and the beta-chain between Lys-53 and Lys-54 but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.

Gene Wiki entry for HABP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HABP2 Gene

Genomics for HABP2 Gene

Regulatory Elements for HABP2 Gene

Enhancers for HABP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HABP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HABP2 Gene

Chromosome:
10
Start:
113,550,831 bp from pter
End:
113,589,602 bp from pter
Size:
38,772 bases
Orientation:
Plus strand

Genomic View for HABP2 Gene

Genes around HABP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HABP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HABP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HABP2 Gene

Proteins for HABP2 Gene

  • Protein details for HABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14520-HABP2_HUMAN
    Recommended name:
    Hyaluronan-binding protein 2
    Protein Accession:
    Q14520
    Secondary Accessions:
    • A8K467
    • B7Z8U5
    • F5H5M6
    • O00663

    Protein attributes for HABP2 Gene

    Size:
    560 amino acids
    Molecular mass:
    62672 Da
    Quaternary structure:
    • Heterodimer; disulfide-linked. Heterodimer of a 50 kDa heavy and a 27 kDa light chain linked by a disulfide bond (By similarity).

    Alternative splice isoforms for HABP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HABP2 Gene

Proteomics data for HABP2 Gene at MOPED

Post-translational modifications for HABP2 Gene

  • Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments (By similarity).
  • Glycosylation at Asn 54 and Asn 207
  • Modification sites at PhosphoSitePlus

Other Protein References for HABP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for HABP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14520

UniProtKB/Swiss-Prot:

HABP2_HUMAN :
  • Contains 3 EGF-like domains.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 3 EGF-like domains.
  • Contains 1 kringle domain.
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with HABP2: view

No data available for Gene Families for HABP2 Gene

Function for HABP2 Gene

Molecular function for HABP2 Gene

UniProtKB/Swiss-Prot Function:
Cleaves the alpha-chain at multiple sites and the beta-chain between Lys-53 and Lys-54 but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.

Enzyme Numbers (IUBMB) for HABP2 Gene

Gene Ontology (GO) - Molecular Function for HABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005539 glycosaminoglycan binding TAS 8827452
genes like me logo Genes that share ontologies with HABP2: view
genes like me logo Genes that share phenotypes with HABP2: view

Human Phenotype Ontology for HABP2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HABP2 Gene

MGI Knock Outs for HABP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for HABP2

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for HABP2 Gene

Localization for HABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HABP2 Gene

Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HABP2 Gene COMPARTMENTS Subcellular localization image for HABP2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
genes like me logo Genes that share ontologies with HABP2: view

Pathways & Interactions for HABP2 Gene

SuperPathways for HABP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HABP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HABP2 Gene

Drugs & Compounds for HABP2 Gene

(5) Drugs for HABP2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma Target, binder 411

(5) Additional Compounds for HABP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HABP2: view

Transcripts for HABP2 Gene

mRNA/cDNA for HABP2 Gene

Unigene Clusters for HABP2 Gene

Hyaluronan binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HABP2 Gene

No ASD Table

Relevant External Links for HABP2 Gene

GeneLoc Exon Structure for
HABP2
ECgene alternative splicing isoforms for
HABP2

Expression for HABP2 Gene

mRNA expression in normal human tissues for HABP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HABP2 Gene

This gene is overexpressed in Liver (x45.3).

Protein differential expression in normal tissues from HIPED for HABP2 Gene

This gene is overexpressed in Serum (30.6), Plasma (14.2), Synovial fluid (8.4), and Vitreous humor (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HABP2 Gene



SOURCE GeneReport for Unigene cluster for HABP2 Gene Hs.422542

mRNA Expression by UniProt/SwissProt for HABP2 Gene

Q14520-HABP2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with HABP2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for HABP2 Gene

Orthologs for HABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HABP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HABP2 35
  • 85.24 (n)
  • 81 (a)
HABP2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HABP2 35
  • 86.3 (n)
  • 82.94 (a)
HABP2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Habp2 35
  • 81.69 (n)
  • 80.08 (a)
Habp2 16
Habp2 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HABP2 35
  • 99.05 (n)
  • 98.75 (a)
HABP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Habp2 35
  • 80.7 (n)
  • 77.96 (a)
oppossum
(Monodelphis domestica)
Mammalia HABP2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HABP2 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves HABP2 35
  • 60.52 (n)
  • 54.38 (a)
HABP2 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HABP2 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia habp2 35
  • 54.09 (n)
  • 46.75 (a)
zebrafish
(Danio rerio)
Actinopterygii habp2 35
  • 56.27 (n)
  • 48.73 (a)
habp2 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6048 37
  • 33 (a)
Tequila 36
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea svh-1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for HABP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HABP2 Gene

ENSEMBL:
Gene Tree for HABP2 (if available)
TreeFam:
Gene Tree for HABP2 (if available)

Paralogs for HABP2 Gene

Paralogs for HABP2 Gene

genes like me logo Genes that share paralogs with HABP2: view

Variants for HABP2 Gene

Sequence variations from dbSNP and Humsavar for HABP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11575750 - 113,575,941(+) GCCTC(A/G)TCCAT reference, missense
rs11575688 - 113,583,298(+) GGGTG(C/G)AGAAG reference, missense
rs7080536 - 113,588,287(+) GTGTG(A/G)GAAGA reference, missense
rs1535426 -- 113,575,664(-) AACCA(A/C)GACTG intron-variant
rs1535427 -- 113,573,992(-) TTAGG(A/T)AAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HABP2 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831994 CNV Gain 17160897
nsv519312 CNV Loss 19592680
dgv821n71 CNV Loss 21882294
nsv525228 CNV Loss 19592680
dgv822n71 CNV Loss 21882294
nsv7555 CNV Loss 18451855

Variation tolerance for HABP2 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HABP2 Gene

HapMap Linkage Disequilibrium report
HABP2
Human Gene Mutation Database (HGMD)
HABP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HABP2 Gene

Disorders for HABP2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for HABP2 Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search HABP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HABP2

Genetic Association Database (GAD)
HABP2
Human Genome Epidemiology (HuGE) Navigator
HABP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HABP2
genes like me logo Genes that share disorders with HABP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HABP2 Gene

Publications for HABP2 Gene

  1. Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator. (PMID: 8827452) Choi-Miura N.-H. … Tomita M. (J. Biochem. 1996) 2 3 4 23 25 67
  2. Factor VII activating protease (FSAP): a novel protease in hemostasis. (PMID: 12437095) RAPmisch J. (Biol. Chem. 2002) 2 3 23
  3. Identification of the substrates for plasma hyaluronan binding protein. (PMID: 11217080) Choi-Miura N.H. … Tomita M. (Biol. Pharm. Bull. 2001) 3 23 25
  4. Polyamine-promoted autoactivation of plasma hyaluronan-binding protein. (PMID: 19817990) Yamamichi S. … Hasumi K. (J. Thromb. Haemost. 2010) 3 23
  5. Hyaluronic Acid binding protein 2 is a novel regulator of vascular integrity. (PMID: 20042707) Mambetsariev N. … Singleton P.A. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 23

Products for HABP2 Gene

Sources for HABP2 Gene

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