Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HABP2 Gene

protein-coding   GIFtS: 62
GCID: GC10P115302

Hyaluronan Binding Protein 2

(Previous name: hyaluronan-binding protein 2)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hyaluronan Binding Protein 21 2     Hepatocyte Growth Factor Activator-Like Protein2 3
FSAP2 3 5     Plasma Hyaluronan-Binding Protein2 3
HGFAL2 3 5     HABP2
PHBP2 3 5     Hyaluronic Acid Binding Protein 22
Hyaluronan-Binding Protein 21 2     EC 3.4.21.-3
Factor VII Activating Protein1 2     EC 3.4.218
Plasma Hyaluronan Binding Protein1 2     EC 3.4.21.48
Factor Seven-Activating Protease2 3     EC 3.4.21.928
Factor VII-Activating Protease2 3     

External Ids:    HGNC: 47981   Entrez Gene: 30262   Ensembl: ENSG000001487027   OMIM: 6039245   UniProtKB: Q145203   

Export aliases for HABP2 gene to outside databases

Previous GC identifers: GC10P114208 GC10P114546 GC10P115444 GC10P114977 GC10P108937


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HABP2 Gene:
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in
cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event
to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is
known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of
fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Apr 2010)

GeneCards Summary for HABP2 Gene: 
HABP2 (hyaluronan binding protein 2) is a protein-coding gene. Diseases associated with HABP2 include follicular mucinosis, and carotid stenosis. GO annotations related to this gene include glycosaminoglycan binding and serine-type endopeptidase activity. An important paralog of this gene is PLG.

UniProtKB/Swiss-Prot: HABP2_HUMAN, Q14520
Function: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the
gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the
fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single
chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor
VII

Gene Wiki entry for HABP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HABP2 gene promoter:
         Oct-B1   oct-B3   oct-B2   Nkx2-2   POU6F1 (c2)   C/EBPalpha   CREB   AREB6   deltaCREB   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHABP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HABP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HABP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q25.3

HABP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HABP2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P115302:  view genomic region     (about GC identifiers)

Start:
115,310,590 bp from pter      End:
115,349,361 bp from pter
Size:
38,772 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HABP2_HUMAN, Q14520 (See protein sequence)
Recommended Name: Hyaluronan-binding protein 2 precursor  
Size: 560 amino acids; 62672 Da
Subunit: Heterodimer; disulfide-linked. Heterodimer of a 50 kDa heavy and a 27 kDa light chain linked by a
disulfide bond (By similarity)
Subcellular location: Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a
heterodimeric form
Secondary accessions: A8K467 B7Z8U5 F5H5M6 O00663
Alternative splicing: 2 isoforms:  Q14520-1   Q14520-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HABP2: NX_Q14520

Explore proteomics data for HABP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or
    Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at
    Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further
    proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14520

  • 4/10 DME Specific Peptides for HABP2 (Q14520) (see all 10)
     GDSGGPL  LESLDPD  VLTAAHC  WVLTAAH 

    HABP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HABP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171131.1  NP_004123.1  

    ENSEMBL proteins: 
     ENSP00000277903   ENSP00000438373   ENSP00000443283   ENSP00000446135  

    Human Recombinant Protein Products for HABP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HABP2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HABP2
    GenScript Custom Purified and Recombinant Proteins Services for HABP2
    Novus Biologicals HABP2 Proteins
    Novus Biologicals HABP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HABP2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space TAS8827452

    HABP2 for ontologies           About GeneDecksing



    HABP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HABP2
    GenScript Custom Superior Antibodies Services for HABP2
    Novus Biologicals HABP2 Antibodies
    Abcam antibodies for HABP2
    Cloud-Clone Corp. Antibodies for HABP2 
    ThermoFisher Antibodies for HABP2
    LSBio Antibodies in human, mouse, rat for HABP2 

    Assay Products for HABP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HABP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HABP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HABP2 
    Cloud-Clone Corp. CLIAs for HABP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR001314 Peptidase_S1A
     IPR000742 EG-like_dom
     IPR018056 Kringle_CS
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q14520

    ProtoNet protein and cluster: Q14520

    4 Blocks protein domains:
    IPB000001 Kringle
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: HABP2_HUMAN, Q14520
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 3 EGF-like domains
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 peptidase S1 domain


    HABP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HABP2_HUMAN, Q14520
    Function: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the
    gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the
    fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single
    chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor
    VII

         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.922 EC 3.4.21.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005509calcium ion binding ----
    GO:0005515protein binding ----
    GO:0005539glycosaminoglycan binding TAS8827452
         
    HABP2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HABP2:
     Decreased cilium length  Decreased cilium length after   Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HABP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HABP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HABP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HABP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HABP2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate HABP2 (see all 12):
    hsa-miR-148b* hsa-miR-4251 hsa-miR-425 hsa-miR-548s hsa-miR-1205 hsa-miR-1911* hsa-miR-3926 hsa-miR-146a*
    SwitchGear 3'UTR luciferase reporter plasmidHABP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HABP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HABP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HABP2
    Sirion Biotech Customized adenovirus for overexpression of HABP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HABP2 (see all 11)
    OriGene ORF clones in mouse, rat for HABP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HABP2 (NM_004132)
    Sino Biological Human cDNA Clone for HABP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HABP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HABP2
    Sirion Biotech Customized lentivirus for stable overexpression of HABP2 
                         Customized lentivirus expression plasmids for stable overexpression of HABP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HABP2
    Search LifeMap BioReagents cell lines for HABP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HABP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HABP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for HABP2 (Q145202, 3 ENSP000002779034) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202054 I2D: score=1 STRING: ENSP00000250416
    COL4A4P534203, ENSP000003798664I2D: score=1 STRING: ENSP00000379866
    COL4A6Q140313, ENSP000003612904I2D: score=1 STRING: ENSP00000361290
    KNG1P010423, ENSP000002650234I2D: score=1 STRING: ENSP00000265023
    COL4A1P024623, ENSP000003649794I2D: score=1 STRING: ENSP00000364979
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007155cell adhesion TAS8827452

    HABP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HABP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HABP2

    1 HMDB Compound for HABP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--

    10 Novoseek inferred chemical compound relationships for HABP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 60.8 26 1724753 (3), 15690337 (2), 20042707 (2), 15035435 (1) (see all 9)
    serine 54.9 42 11256474 (3), 8827452 (2), 15320789 (2), 11379758 (2) (see all 20)
    dextran sulfate 54.4 4 17300216 (1), 15320789 (1), 15654766 (1)
    heparin 45.9 19 19664058 (6), 15035435 (2), 14977886 (1), 15654766 (1) (see all 9)
    kininogen 42.6 1 16972797 (1)
    heparan sulfate 40.4 3 15035435 (1), 16972797 (1)
    fibrinogen 25.4 3 11217080 (2), 15320789 (1)
    phosphatidylethanolamine 18.8 1 15320789 (1)
    glutaraldehyde 17 1 12788561 (1)
    calcium 0 3 11432747 (1), 15654766 (1)

    Search CenterWatch for drugs/clinical trials and news about HABP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HABP2 gene (2 alternative transcripts): 
    NM_001177660.1  NM_004132.3  

    Unigene Cluster for HABP2:

    Hyaluronan binding protein 2
    Hs.422542  [show with all ESTs]
    Unigene Representative Sequence: NM_004132
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351270(uc010qrz.1 uc001lai.4) ENST00000460714 ENST00000541666
    ENST00000542051(uc021pyr.1) ENST00000537906(uc010qry.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HABP2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate HABP2 (see all 12):
    hsa-miR-148b* hsa-miR-4251 hsa-miR-425 hsa-miR-548s hsa-miR-1205 hsa-miR-1911* hsa-miR-3926 hsa-miR-146a*
    SwitchGear 3'UTR luciferase reporter plasmidHABP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HABP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HABP2
    Clone
    Products:
         
    OriGene clones in human, mouse for HABP2 (see all 11)
    OriGene ORF clones in mouse, rat for HABP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HABP2 (NM_004132)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HABP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HABP2
    Sirion Biotech Customized lentivirus for stable overexpression of HABP2 
                         Customized lentivirus expression plasmids for stable overexpression of HABP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HABP2
    OriGene qSTAR qPCR primer pairs in human, mouse for HABP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HABP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HABP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HABP2

    Additional mRNA sequence: 

    AK290832.1 AK303759.1 AK303761.1 AK303948.1 BC031412.1 D49742.1 S83182.1 

    3 DOTS entries:

    DT.418518  DT.100789919  DT.99981377 

    24/81 AceView cDNA sequences (see all 81):

    BI761782 AI056527 CB162144 NM_004132 BX115262 AW771531 AI373912 AI521915 
    BC031412 CB164181 BX325239 CB163846 N94159 N70728 AI522105 F00191 
    H91225 AW571745 H91171 N58034 AW271339 AI242870 H90922 AW190500 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HABP2 expression in normal human tissues (normalized intensities)      HABP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCACAACA
    HABP2 Expression
    About this image


    HABP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Gut Tube (Gastrointestinal Tract)
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...
     
     Lung (Respiratory System)
             bronchus ; respiratory epithelial cells   

    See HABP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HABP2

    SOURCE GeneReport for Unigene cluster: Hs.422542

    UniProtKB/Swiss-Prot: HABP2_HUMAN, Q14520
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for HABP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HABP2
    OriGene qSTAR qPCR primer pairs in human, mouse for HABP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HABP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HABP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HABP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HABP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HABP2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Habp21 , 5 hyaluronic acid binding protein 21, 5 81.93(n)1
    80.82(a)1
      19 (51.79 cM)5
    2262431  NM_146101.11  NP_666213.11 
     562871375 
    chicken
    (Gallus gallus)
    Aves HABP21 hyaluronan binding protein 2 60.65(n)
    54.56(a)
      423898  XM_421761.2  XP_421761.1 
    lizard
    (Anolis carolinensis)
    Reptilia HABP26
    hyaluronan binding protein 2
    52(a)
    1 ↔ 1
    GL343204.1(722206-786605)
    zebrafish
    (Danio rerio)
    Actinopterygii habp21 hyaluronan binding protein 2 56.27(n)
    48.73(a)
      553472  NM_001110373.1  NP_001103843.1 
    worm
    (Caenorhabditis elegans)
    Secernentea svh-16
    Protein SVH-1
    13(a)
    1 → many
    IV(8206614-8213723)


    ENSEMBL Gene Tree for HABP2 (if available)
    TreeFam Gene Tree for HABP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HABP2 gene
    PLG2  PLAT2  HGFAC2  LPA2  PLAU2  MST12  F122  HGF2  
    18/32 SIMAP similar genes for HABP2 using alignment to 4 protein entries:     HABP2_HUMAN (see all proteins) (see all similar genes):
    BCAN    APOA    PRSS2    TRY8    LPAL2    GZMK
    KLK12    KLK13    CTRB2    KLK9    PLAT    CTSG
    PRSS3    TPSAB1    TPSB2    ATF    CMA1    GZMA

    HABP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1135 SNPs in HABP2 are shown (see all 1135)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70805361,2,4
    C,F,Hpathogenic1115703932(+) GTGTGG/AGAAGA 4 /E /G mis115Minor allele frequency- A:0.02NS EA NA EU 7109
    rs719654121,2
    C--108973360(+) TGTGG-/TGTGGGGG 2 -- cds10--------
    rs37813931,2
    C,F--115311495(-) CTCTGT/CCTCCT 2 -- us2k1 int11Minor allele frequency- C:0.00WA 2
    rs111963721,2
    C,F--115315813(+) CCTCTC/-CCCTG 2 -- int1 trp32Minor allele frequency- -:0.22NS 90
    rs3726195111,2
    C--115324609(+) TCTCT-/TTTTGT 2 -- int10--------
    rs115757451,2
    C,F--115334304(+) TTTTT-/TCTGTT 2 -- int1 trp33Minor allele frequency- T:0.05NS NA 94
    rs1117773231,2
    C--115334796(+) AAAAGAAAAT/
            
    AAGAA
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs113277361,2
    C--115338854(+) AAAAA-/ATAGCT 2 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs340069761,2
    C--115339846(+) TTTTTT/-CACAA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs580424811,2
    C--115346235(+) GGGGG-/GTGTTT 2 -- int11Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for HABP2 (115310590 - 115349361 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HABP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525228CNV Loss19592680
    nsv519312CNV Loss19592680
    nsv7555CNV Loss18451855
    dgv821n71CNV Loss21882294
    dgv822n71CNV Loss21882294
    nsv831994CNV Gain17160897
    nsv7211OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): HABP2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HABP2
    DNA2.0 Custom Variant and Variant Library Synthesis for HABP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603924   
    OMIM disorders: 188050  
    20/36 diseases for HABP2 (see all 36):    About MalaCards
    follicular mucinosis    carotid stenosis    factor vii marburg i variant thrombophilia    venous thromboembolism
    prothrombin-related thrombophilia    thromboembolism    visceral leishmaniasis    dermatofibrosarcoma
    dermatofibrosarcoma protuberans    thrombophilia    malignant pleural mesothelioma    interstitial lung disease
    squamous cell carcinoma of the head and neck    leishmaniasis    cerebral infarction    keloids
    thrombosis    basal cell carcinoma    lung adenocarcinoma    atherosclerosis

    1 disease from the University of Copenhagen DISEASES database for HABP2:
    Carotid stenosis

    HABP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for HABP2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thromboembolism 49.2 17 16543963 (2), 15486068 (2), 18278202 (1), 16676090 (1) (see all 8)
    carotid stenosis 47.8 13 12578864 (2), 18605956 (1), 14977886 (1), 15486068 (1)
    pathological processes 13.4 1 15035435 (1)
    atherosclerosis 3.31 5 19664058 (1), 18278176 (1)
    inflammation 1.35 4 1856461 (1), 17483138 (1), 18394684 (1)
    cardiovascular diseases 0 2 19446554 (1)
    carcinoma squamous cell 0 1 12386823 (1)
    breast carcinoma 0 1 15690337 (1)
    adenocarcinoma 0 2 12386823 (1)
    nsclc 0 1 17016581 (1)

    Genetic Association Database (GAD): HABP2
    Human Genome Epidemiology (HuGE) Navigator: HABP2 (14 documents)

    Export disorders for HABP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HABP2 gene, integrated from 9 sources (see all 126):
    (articles sorted by number of sources associating them with HABP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator. (PubMed id 8827452)1, 2, 3, 9 Choi-Miura N.-H....Tomita M. (1996)
    2. Factor VII-activating protease in patients with acute deep venous thrombosis. (PubMed id 18394684)1, 4, 9 Sidelmann J.J....Jespersen J. (2008)
    3. Factor VII activating protease (FSAP): a novel protease in hemostasis. (PubMed id 12437095)1, 3, 9 Romisch J. (2002)
    4. The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB. (PubMed id 19105210)1, 4, 9 Wasmuth H.E....Weiskirchen R. (2009)
    5. Marburg I polymorphism of factor VII-activating prote ase is associated with idiopathic venous thromboembolism. (PubMed id 15486068)1, 4, 9 Hoppe B....Salama A. (2005)
    6. Marburg I polymorphism of factor VII-activating protease: a prominent risk predictor of carotid stenosis. (PubMed id 12578864)1, 2, 9 Willeit J....Roemisch J. (2003)
    7. Identification of the substrates for plasma hyaluronan binding protein. (PubMed id 11217080)1, 2, 9 Choi-Miura N.H.... Tomita M. (2001)
    8. Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population. (PubMed id 17003923)1, 4, 9 Hoppe B....Salama A. (2006)
    9. The factor VII activating protease G511E (Marburg) variant and cardiovascular risk. (PubMed id 15543324)1, 4, 9 Ireland H....Humphries S.E. (2004)
    10. Study of 18 functional hemostatic polymorphisms in mu cocutaneous bleeding disorders. (PubMed id 20532885)1, 4 AntA^n A.I....Mezzano D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3026 HGNC: 4798 AceView: HABP2 Ensembl:ENSG00000148702 euGenes: HUgn3026
    ECgene: HABP2 H-InvDB: HABP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HABP2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/habp2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HABP2 gene:
    Search GeneIP for patents involving HABP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HABP2  
     OriGene qPCR primer pairs and template standards for HABP2   OriGene Protein Over-expression Lysate for HABP2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HABP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for HABP2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HABP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HABP2   OriGene Custom Protein Services for HABP2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HABP2
     QIAGEN SeqTarget long-range PCR primers for resequencing HABP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HABP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HABP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HABP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HABP2
     GenScript Custom Purified and Recombinant Proteins Services for HABP2 GenScript cDNA clones with any tag delivered in your preferred vector for HABP2
     GenScript Custom Assay Services for HABP2 GenScript Custom Superior Antibodies Services for HABP2
     GenScript Custom overexpressing Cell Line Services for HABP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HABP2 promoter
     Search Chromatin IP Primers for HABP2
     RT2 qPCR Primer Assay in human, mouse, rat HABP2
     GNC Network for HABP2
     SABiosciences Custom PCR Arrays for HABP2
     Search Tocris compounds for HABP2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for HABP2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HABP2 antibodies
     HABP2 proteins
     HABP2 lysates
     Antibodies for HABP2
     See all of Abcam's Antibodies, Kits and Proteins for HABP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for HABP2
     Antibodies for HABP2
     ELISAs for HABP2
     CLIAs for HABP2
     Search LifeMap BioReagents cell lines for HABP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HABP2
     SwitchGear 3'UTR luciferase reporter plasmids for HABP2
     SwitchGear Promoter luciferase reporter plasmids for HABP2
     ThermoFisher Antibodies for HABP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HABP2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HABP2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HABP2
    Customized:
     lentivirus for stable overexpression of HABP2
     lentivirus expression plasmids for stable overexpression of HABP2
     adenovirus for overexpression of HABP2
     LSBio Antibodies in human, mouse, rat for HABP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HABP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4