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HABP2 Gene

protein-coding   GIFtS: 62
GCID: GC10P115302

Hyaluronan Binding Protein 2

(Previous name: hyaluronan-binding protein 2)
  See HABP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hyaluronan Binding Protein 21 2     Hepatocyte Growth Factor Activator-Like Protein2 3
FSAP2 3 5     Plasma Hyaluronan-Binding Protein2 3
HGFAL2 3 5     HABP2
PHBP2 3 5     Hyaluronic Acid Binding Protein 22
Hyaluronan-Binding Protein 21 2     EC 3.4.21.-3
Factor VII Activating Protein1 2     EC 3.4.218
Plasma Hyaluronan Binding Protein1 2     EC 3.4.21.48
Factor Seven-Activating Protease2 3     EC 3.4.21.928
Factor VII-Activating Protease2 3     

External Ids:    HGNC: 47981   Entrez Gene: 30262   Ensembl: ENSG000001487027   OMIM: 6039245   UniProtKB: Q145203   

Export aliases for HABP2 gene to outside databases

Previous GC identifers: GC10P114208 GC10P114546 GC10P115444 GC10P114977 GC10P108937


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HABP2 Gene:
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in
cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event
to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is
known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of
fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Apr 2010)

GeneCards Summary for HABP2 Gene:
HABP2 (hyaluronan binding protein 2) is a protein-coding gene. Diseases associated with HABP2 include venous thromboembolism, and factor vii marburg i variant thrombophilia. GO annotations related to this gene include glycosaminoglycan binding and serine-type endopeptidase activity. An important paralog of this gene is PLG.

UniProtKB/Swiss-Prot: HABP2_HUMAN, Q14520
Function: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the
gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the
fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single
chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor
VII

Gene Wiki entry for HABP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the HABP2 gene promoter:
         Oct-B1   oct-B3   oct-B2   Nkx2-2   POU6F1 (c2)   C/EBPalpha   CREB   AREB6   deltaCREB   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHABP2 promoter sequence
   Search Chromatin IP Primers for HABP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HABP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q25.3

HABP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HABP2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P115302:  view genomic region     (about GC identifiers)

Start:
115,310,590 bp from pter      End:
115,349,361 bp from pter
Size:
38,772 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HABP2_HUMAN, Q14520 (See protein sequence)
Recommended Name: Hyaluronan-binding protein 2 precursor  
Size: 560 amino acids; 62672 Da
Subunit: Heterodimer; disulfide-linked. Heterodimer of a 50 kDa heavy and a 27 kDa light chain linked by a
disulfide bond (By similarity)
Secondary accessions: A8K467 B7Z8U5 F5H5M6 O00663
Alternative splicing: 2 isoforms:  Q14520-1   Q14520-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HABP2: NX_Q14520

Explore proteomics data for HABP2 at MOPED

Post-translational modifications: 

  • Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or
    Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at
    Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further
    proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments (By similarity)1
  • Glycosylation2 at Asn54, Asn207
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HABP2 (Q14520) (see all 10)
     GDSGGPL  LESLDPD  VLTAAHC  WVLTAAH 


    See HABP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171131.1  NP_004123.1  

    ENSEMBL proteins: 
     ENSP00000277903   ENSP00000438373   ENSP00000443283   ENSP00000446135  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR001314 Peptidase_S1A
     IPR000742 EG-like_dom
     IPR018056 Kringle_CS
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q14520

    ProtoNet protein and cluster: Q14520

    4 Blocks protein domains:
    IPB000001 Kringle
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: HABP2_HUMAN, Q14520
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 3 EGF-like domains
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with HABP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HABP2_HUMAN, Q14520
    Function: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the
    gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the
    fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single
    chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor
    VII

         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.922 EC 3.4.21.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005509calcium ion binding ----
    GO:0005515protein binding ----
    GO:0005539glycosaminoglycan binding TAS8827452
         
    Find genes that share ontologies with HABP2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HABP2:
     Decreased cilium length  Decreased cilium length after   Increased G1 DNA content 

    Animal Models:
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    hsa-miR-148b* hsa-miR-4251 hsa-miR-425 hsa-miR-548s hsa-miR-1205 hsa-miR-1911* hsa-miR-3926 hsa-miR-146a*
    SwitchGear 3'UTR luciferase reporter plasmidHABP2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HABP2_HUMAN, Q14520: Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a
    heterodimeric form
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space TAS8827452

    Find genes that share ontologies with HABP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HABP2
    Interactions:

        GeneGlobe Interaction Network for HABP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for HABP2 (Q145202, 3 ENSP000002779034) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202054 I2D: score=1 STRING: ENSP00000250416
    COL4A4P534203, ENSP000003798664I2D: score=1 STRING: ENSP00000379866
    COL4A6Q140313, ENSP000003612904I2D: score=1 STRING: ENSP00000361290
    KNG1P010423, ENSP000002650234I2D: score=1 STRING: ENSP00000265023
    COL4A1P024623, ENSP000003649794I2D: score=1 STRING: ENSP00000364979
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007155cell adhesion TAS8827452

    Find genes that share ontologies with HABP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HABP2

    1 HMDB Compound for HABP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--

    10 Novoseek inferred chemical compound relationships for HABP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 60.8 26 1724753 (3), 15690337 (2), 20042707 (2), 15035435 (1) (see all 9)
    serine 54.9 42 11256474 (3), 8827452 (2), 15320789 (2), 11379758 (2) (see all 20)
    dextran sulfate 54.4 4 17300216 (1), 15320789 (1), 15654766 (1)
    heparin 45.9 19 19664058 (6), 15035435 (2), 14977886 (1), 15654766 (1) (see all 9)
    kininogen 42.6 1 16972797 (1)
    heparan sulfate 40.4 3 15035435 (1), 16972797 (1)
    fibrinogen 25.4 3 11217080 (2), 15320789 (1)
    phosphatidylethanolamine 18.8 1 15320789 (1)
    glutaraldehyde 17 1 12788561 (1)
    calcium 0 3 11432747 (1), 15654766 (1)



    Find genes that share compounds with HABP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HABP2 gene (2 alternative transcripts): 
    NM_001177660.1  NM_004132.3  

    Unigene Cluster for HABP2:

    Hyaluronan binding protein 2
    Hs.422542  [show with all ESTs]
    Unigene Representative Sequence: NM_004132
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351270(uc010qrz.1 uc001lai.4) ENST00000460714 ENST00000541666
    ENST00000542051(uc021pyr.1) ENST00000537906(uc010qry.1)
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    hsa-miR-148b* hsa-miR-4251 hsa-miR-425 hsa-miR-548s hsa-miR-1205 hsa-miR-1911* hsa-miR-3926 hsa-miR-146a*
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      QuantiFast Probe-based Assays in human, mouse, rat HABP2

    Additional mRNA sequence: 

    AK290832.1 AK303759.1 AK303761.1 AK303948.1 BC031412.1 D49742.1 S83182.1 

    3 DOTS entries:

    DT.418518  DT.100789919  DT.99981377 

    Selected AceView cDNA sequences (see all 81):

    CB164181 AI373912 AW771531 NM_004132 AI521915 BC031412 BX115262 CB162144 
    BI761782 AI056527 BP340909 AI522105 AA634751 BX325239 AI674836 BP343510 
    AW571745 AI242870 AW271339 N94159 H91171 N70728 S83182 T68666 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HABP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCACAACA
    HABP2 Expression
    About this image


    HABP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             DKK1-induced cells
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    HABP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HABP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.422542

    UniProtKB/Swiss-Prot: HABP2_HUMAN, Q14520
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HABP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HABP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Habp21 , 5 hyaluronic acid binding protein 21, 5 81.69(n)1
    80.08(a)1
      19 (51.79 cM)5
    2262431  NM_146101.11  NP_666213.11 
     562871375 
    chicken
    (Gallus gallus)
    Aves HABP21 hyaluronan binding protein 2 60.52(n)
    54.38(a)
      423898  NM_001277379.1  NP_001264308.1 
    lizard
    (Anolis carolinensis)
    Reptilia HABP26
    hyaluronan binding protein 2
    53(a)
    1 ↔ 1
    GL343204.1(722206-786605)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia habp21 hyaluronan binding protein 2 54.09(n)
    46.75(a)
      548376  XM_002939499.2  XP_002939545.2 
    zebrafish
    (Danio rerio)
    Actinopterygii habp21 hyaluronan binding protein 2 56.27(n)
    48.73(a)
      553472  NM_001110373.1  NP_001103843.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60483 serine-type endopeptidase 33(a)   5C10   --
    worm
    (Caenorhabditis elegans)
    Secernentea svh-16
    Protein SVH-1 (svh-1) mRNA, complete cds
    16(a)
    1 → many
    IV(8206614-8213723) WBGene00006620


    ENSEMBL Gene Tree for HABP2 (if available)
    TreeFam Gene Tree for HABP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HABP2 gene
    PLG2  PLAT2  HGFAC2  LPA2  PLAU2  MST12  F122  HGF2  
    Selected SIMAP similar genes for HABP2 using alignment to 4 protein entries:     HABP2_HUMAN (see all proteins) (see all similar genes):
    BCAN    APOA    PRSS2    TRY8    LPAL2    GZMK
    KLK12    KLK13    CTRB2    KLK9    PLAT    CTSG
    PRSS3    TPSAB1    TPSB2    ATF    CMA1    GZMA

    Find genes that share paralogs with HABP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HABP2 (see all 1135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70805361,2,,4
    C,F,Hpathogenic1115703932(+) GTGTGG/AGAAGA 4 /E /G mis115Minor allele frequency- A:0.02NS EA NA EU 7109
    rs719654121,2
    C--108973360(+) TGTGG-/TGTGGGGG 2 -- cds10--------
    rs37813931,2
    C,F--115311495(-) CTCTGT/CCTCCT 2 -- us2k1 int11Minor allele frequency- C:0.00WA 2
    rs111963721,2
    C,F--115315813(+) CCTCTC/-CCCTG 2 -- int1 trp32Minor allele frequency- -:0.22NS 90
    rs3726195111,2
    C--115324609(+) TCTCT-/TTTTGT 2 -- int10--------
    rs115757451,2
    C,F--115334304(+) TTTTT-/TCTGTT 2 -- int1 trp33Minor allele frequency- T:0.05NS NA 94
    rs1117773231,2
    C--115334796(+) AAAAGAAAAT/
            
    AAGAA
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs113277361,2
    C--115338854(+) AAAAA-/ATAGCT 2 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs340069761,2
    C--115339846(+) TTTTTT/-CACAA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs580424811,2
    C--115346235(+) GGGGG-/GTGTTT 2 -- int11Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for HABP2 (115310590 - 115349361 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HABP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525228CNV Loss19592680
    nsv519312CNV Loss19592680
    nsv7555CNV Loss18451855
    dgv821n71CNV Loss21882294
    dgv822n71CNV Loss21882294
    nsv831994CNV Gain17160897
    nsv7211OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): HABP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HABP2
    DNA2.0 Custom Variant and Variant Library Synthesis for HABP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603924   
    OMIM disorders: 188050  
    6 diseases for HABP2:    
    About MalaCards
    venous thromboembolism    factor vii marburg i variant thrombophilia    carotid stenosis    follicular mucinosis
    prothrombin-related thrombophilia    thromboembolism

    1 disease from the University of Copenhagen DISEASES database for HABP2:
    Carotid stenosis

    Find genes that share disorders with HABP2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HABP2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thromboembolism 49.2 17 16543963 (2), 15486068 (2), 18278202 (1), 16676090 (1) (see all 8)
    carotid stenosis 47.8 13 12578864 (2), 18605956 (1), 14977886 (1), 15486068 (1)
    pathological processes 13.4 1 15035435 (1)
    atherosclerosis 3.31 5 19664058 (1), 18278176 (1)
    inflammation 1.35 4 1856461 (1), 17483138 (1), 18394684 (1)
    cardiovascular diseases 0 2 19446554 (1)
    carcinoma squamous cell 0 1 12386823 (1)
    breast carcinoma 0 1 15690337 (1)
    adenocarcinoma 0 2 12386823 (1)
    nsclc 0 1 17016581 (1)

    Genetic Association Database (GAD): HABP2
    Human Genome Epidemiology (HuGE) Navigator: HABP2 (14 documents)

    Export disorders for HABP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HABP2 gene, integrated from 10 sources (see all 126):
    (articles sorted by number of sources associating them with HABP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator. (PubMed id 8827452)1, 2, 3, 9 Choi-Miura N.-H....Tomita M. (J. Biochem. 1996)
    2. Factor VII-activating protease in patients with acute deep venous thrombosis. (PubMed id 18394684)1, 4, 9 Sidelmann J.J....Jespersen J. (Thromb. Res. 2008)
    3. Factor VII activating protease (FSAP): a novel protease in hemostasis. (PubMed id 12437095)1, 3, 9 RAPmisch J. (Biol. Chem. 2002)
    4. The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB. (PubMed id 19105210)1, 4, 9 Wasmuth H.E....Weiskirchen R. (Hepatology 2009)
    5. Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism. (PubMed id 15486068)1, 4, 9 Hoppe B....Salama A. (Blood 2005)
    6. Marburg I polymorphism of factor VII-activating protease: a prominent risk predictor of carotid stenosis. (PubMed id 12578864)1, 2, 9 Willeit J....Roemisch J. (Circulation 2003)
    7. Identification of the substrates for plasma hyaluronan binding protein. (PubMed id 11217080)1, 2, 9 Choi-Miura N.H.... Tomita M. (Biol. Pharm. Bull. 2001)
    8. Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population. (PubMed id 17003923)1, 4, 9 Hoppe B....Salama A. (Thromb. Haemost. 2006)
    9. The factor VII activating protease G511E (Marburg) variant and cardiovascular risk. (PubMed id 15543324)1, 4, 9 Ireland H....Humphries S.E. (Thromb. Haemost. 2004)
    10. Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders. (PubMed id 20532885)1, 4 AntA^n A.I....Mezzano D. (Ann. Hematol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3026 HGNC: 4798 AceView: HABP2 Ensembl:ENSG00000148702 euGenes: HUgn3026
    ECgene: HABP2 H-InvDB: HABP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HABP2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/habp2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HABP2 gene:
    Search GeneIP for patents involving HABP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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