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Aliases for HABP2 Gene

Aliases for HABP2 Gene

  • Hyaluronan Binding Protein 2 2 3
  • HGFAL 3 4 6
  • FSAP 3 4 6
  • PHBP 3 4 6
  • Hepatocyte Growth Factor Activator-Like Protein 3 4
  • Plasma Hyaluronan Binding Protein 2 3
  • Plasma Hyaluronan-Binding Protein 3 4
  • Factor Seven-Activating Protease 3 4
  • Factor VII-Activating Protease 3 4
  • Factor VII Activating Protein 2 3
  • Hyaluronan-Binding Protein 2 2 3
  • Hyaluronic Acid Binding Protein 2 3
  • EC 3.4.21.92 64
  • EC 3.4.21.4 64
  • EC 3.4.21.- 4
  • EC 3.4.21 64
  • HABP 3

External Ids for HABP2 Gene

Summaries for HABP2 Gene

Entrez Gene Summary for HABP2 Gene

  • The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

GeneCards Summary for HABP2 Gene

HABP2 (Hyaluronan Binding Protein 2) is a Protein Coding gene. Diseases associated with HABP2 include follicular mucinosis and carotid stenosis. GO annotations related to this gene include serine-type endopeptidase activity and glycosaminoglycan binding. An important paralog of this gene is PLAT.

UniProtKB/Swiss-Prot for HABP2 Gene

  • Cleaves the alpha-chain at multiple sites and the beta-chain between Lys-53 and Lys-54 but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.

Gene Wiki entry for HABP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HABP2 Gene

Genomics for HABP2 Gene

Genomic Location for HABP2 Gene

Start:
113,550,831 bp from pter
End:
113,589,602 bp from pter
Size:
38,772 bases
Orientation:
Plus strand

Genomic View for HABP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HABP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HABP2 Gene

Regulatory Elements for HABP2 Gene

Proteins for HABP2 Gene

  • Protein details for HABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14520-HABP2_HUMAN
    Recommended name:
    Hyaluronan-binding protein 2
    Protein Accession:
    Q14520
    Secondary Accessions:
    • A8K467
    • B7Z8U5
    • F5H5M6
    • O00663

    Protein attributes for HABP2 Gene

    Size:
    560 amino acids
    Molecular mass:
    62672 Da
    Quaternary structure:
    • Heterodimer; disulfide-linked. Heterodimer of a 50 kDa heavy and a 27 kDa light chain linked by a disulfide bond (By similarity).

    Alternative splice isoforms for HABP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HABP2 Gene

Proteomics data for HABP2 Gene at MOPED

Post-translational modifications for HABP2 Gene

  • Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn54 and Asn207

Other Protein References for HABP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for HABP2 Gene

UniProtKB/Swiss-Prot:

HABP2_HUMAN
Domain:
  • Contains 3 EGF-like domains.:
    • Q14520
  • Contains 1 kringle domain.:
    • Q14520
  • Contains 1 peptidase S1 domain.:
    • Q14520
Family:
  • Belongs to the peptidase S1 family.:
    • Q14520
genes like me logo Genes that share domains with HABP2: view

No data available for Gene Families for HABP2 Gene

Function for HABP2 Gene

Molecular function for HABP2 Gene

UniProtKB/Swiss-Prot Function: Cleaves the alpha-chain at multiple sites and the beta-chain between Lys-53 and Lys-54 but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.

Enzyme Numbers (IUBMB) for HABP2 Gene

Gene Ontology (GO) - Molecular Function for HABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005509 calcium ion binding --
GO:0005515 protein binding --
GO:0005539 glycosaminoglycan binding TAS 8827452
genes like me logo Genes that share ontologies with HABP2: view

Phenotypes for HABP2 Gene

genes like me logo Genes that share phenotypes with HABP2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HABP2 Gene

Localization for HABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HABP2 Gene

Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HABP2 Gene COMPARTMENTS Subcellular localization image for HABP2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space TAS 8827452
genes like me logo Genes that share ontologies with HABP2: view

Pathways for HABP2 Gene

SuperPathways for HABP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion TAS 8827452
genes like me logo Genes that share ontologies with HABP2: view

No data available for Pathways by source for HABP2 Gene

Compounds for HABP2 Gene

(1) HMDB Compounds for HABP2 Gene

Compound Synonyms Cas Number PubMed IDs
Hyaluronan
  • hyaluronic acid
9004-61-9

(10) Novoseek inferred chemical compound relationships for HABP2 Gene

Compound -log(P) Hits PubMed IDs
hyaluronic acid 60.8 13
serine 54.9 25
dextran sulfate 54.4 3
heparin 45.9 15
kininogen 42.6 1
genes like me logo Genes that share compounds with HABP2: view

Transcripts for HABP2 Gene

mRNA/cDNA for HABP2 Gene

Unigene Clusters for HABP2 Gene

Hyaluronan binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HABP2 Gene

No ASD Table

Relevant External Links for HABP2 Gene

GeneLoc Exon Structure for
HABP2
ECgene alternative splicing isoforms for
HABP2

Expression for HABP2 Gene

mRNA expression in normal human tissues for HABP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HABP2 Gene

This gene is overexpressed in Liver (45.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HABP2 Gene

SOURCE GeneReport for Unigene cluster for HABP2 Gene Hs.422542

mRNA Expression by UniProt/SwissProt for HABP2 Gene

Q14520-HABP2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with HABP2: view

Orthologs for HABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HABP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HABP2 36
  • 99.05 (n)
  • 98.75 (a)
HABP2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HABP2 36
  • 85.24 (n)
  • 81 (a)
HABP2 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HABP2 36
  • 86.3 (n)
  • 82.94 (a)
HABP2 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Habp2 36
  • 81.69 (n)
  • 80.08 (a)
Habp2 16
Habp2 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HABP2 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HABP2 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Habp2 36
  • 80.7 (n)
  • 77.96 (a)
chicken
(Gallus gallus)
Aves HABP2 36
  • 60.52 (n)
  • 54.38 (a)
HABP2 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HABP2 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia habp2 36
  • 54.09 (n)
  • 46.75 (a)
zebrafish
(Danio rerio)
Actinopterygii habp2 36
  • 56.27 (n)
  • 48.73 (a)
habp2 37
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tequila 37
  • 6 (a)
OneToMany
CG6048 38
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea svh-1 37
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToOne
Species with no ortholog for HABP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HABP2 Gene

ENSEMBL:
Gene Tree for HABP2 (if available)
TreeFam:
Gene Tree for HABP2 (if available)

Paralogs for HABP2 Gene

Paralogs for HABP2 Gene

genes like me logo Genes that share paralogs with HABP2: view

Variants for HABP2 Gene

Sequence variations from dbSNP and Humsavar for HABP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs911700 -- 113,584,093(-) GAGAA(C/G)CACCA intron-variant
rs911701 -- 113,584,072(-) GCTCA(A/T)GAAGG intron-variant
rs911702 -- 113,584,063(-) GGTGG(A/C)CACAG intron-variant
rs911703 -- 113,584,044(-) CACCT(A/G)CCCCC intron-variant
rs911704 -- 113,583,941(-) AATGA(C/T)AATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HABP2 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831994 CNV Gain 17160897
nsv519312 CNV Loss 19592680
dgv821n71 CNV Loss 21882294
nsv525228 CNV Loss 19592680
dgv822n71 CNV Loss 21882294
nsv7555 CNV Loss 18451855

Relevant External Links for HABP2 Gene

HapMap Linkage Disequilibrium report
HABP2
Human Gene Mutation Database (HGMD)
HABP2

Disorders for HABP2 Gene

(1) OMIM Diseases for HABP2 Gene (603924)

(1) University of Copenhagen DISEASES for HABP2 Gene

(11) Novoseek inferred disease relationships for HABP2 Gene

Disease -log(P) Hits PubMed IDs
thromboembolism 49.2 10
carotid stenosis 47.8 5
pathological processes 13.4 1
atherosclerosis 3.31 2
inflammation 1.35 3

Relevant External Links for HABP2

Genetic Association Database (GAD)
HABP2
Human Genome Epidemiology (HuGE) Navigator
HABP2
genes like me logo Genes that share disorders with HABP2: view

No data available for UniProtKB/Swiss-Prot for HABP2 Gene

Publications for HABP2 Gene

  1. Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator. (PMID: 8827452) Choi-Miura N.-H. … Tomita M. (J. Biochem. 1996) 2 3 4 23
  2. Marburg I polymorphism of factor VII-activating protease: a prominent risk predictor of carotid stenosis. (PMID: 12578864) Willeit J. … Roemisch J. (Circulation 2003) 3 4 23
  3. Identification of the substrates for plasma hyaluronan binding protein. (PMID: 11217080) Choi-Miura N.H. … Tomita M. (Biol. Pharm. Bull. 2001) 3 4 23
  4. Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism. (PMID: 15486068) Hoppe B. … Salama A. (Blood 2005) 3 23 49
  5. The factor VII activating protease G511E (Marburg) variant and cardiovascular risk. (PMID: 15543324) Ireland H. … Humphries S.E. (Thromb. Haemost. 2004) 3 23 49

Products for HABP2 Gene

Sources for HABP2 Gene

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