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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HAAO Gene

protein-coding   GIFtS: 64
GCID: GC02M042994

3-Hydroxyanthranilate 3,4-Dioxygenase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
3-Hydroxyanthranilate 3,4-Dioxygenase1 2     HAD2 3
3-HAO2 3     EC 1.13.11.63 8
3-Hydroxyanthranilate Oxygenase2 3     HAO2
3-Hydroxyanthranilic Acid Dioxygenase2 3     

External Ids:    HGNC: 47961   Entrez Gene: 234982   Ensembl: ENSG000001628827   OMIM: 6045215   UniProtKB: P469523   

Export aliases for HAAO gene to outside databases

Previous GC identifers: GC02M042982 GC02M043162 GC02M042968 GC02M042905 GC02M042847 GC02M042728


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAAO Gene:
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular
dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and
kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of
quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its
ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate
in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders
associated with altered tissue levels of QUIN. (provided by RefSeq, Jul 2008)

GeneCards Summary for HAAO Gene: 
HAAO (3-hydroxyanthranilate 3,4-dioxygenase) is a protein-coding gene. Diseases associated with HAAO include pellagra, and conduct disorder, and among its related super-pathways are tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde and Tryptophan metabolism. GO annotations related to this gene include electron carrier activity and ferrous iron binding.

UniProtKB/Swiss-Prot: 3HAO_HUMAN, P46952
Function: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde,
which spontaneously cyclizes to quinolinate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HAAO gene promoter:
         PPAR-gamma1   HTF   FOXD3   SEF-1 (1)   PPAR-gamma2   Pax-4a   E4BP4   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHAAO promoter sequence
   Search SABiosciences Chromatin IP Primers for HAAO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HAAO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p

HAAO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAAO gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M042994:  view genomic region     (about GC identifiers)

Start:
42,994,229 bp from pter      End:
43,019,751 bp from pter
Size:
25,523 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 3HAO_HUMAN, P46952 (See protein sequence)
Recommended Name: 3-hydroxyanthranilate 3,4-dioxygenase  
Size: 286 amino acids; 32556 Da
Cofactor: Fe(2+) ion
Subunit: Monomer
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for HAAO:
2QNK (3D)    
Secondary accessions: A6NE56 B4DIN2 Q53QZ7 Q8N6N9
Alternative splicing: 2 isoforms:  P46952-1   P46952-2   

Explore the universe of human proteins at neXtProt for HAAO: NX_P46952

Explore proteomics data for HAAO at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P46952

  • 3 DME Specific Peptides for HAAO (P46952)
     VPHSPQR  PPVCNKL  RKDYHIEEGEE 

    HAAO Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HAAO Protein Expression
    REFSEQ proteins: NP_036337.2  
    ENSEMBL proteins: 
     ENSP00000294973   ENSP00000412601  
    Reactome Protein details: P46952
    Human Recombinant Protein Products for HAAO: 
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    ProSpec Recombinant Protein for HAAO
    Cloud-Clone Corp. Proteins for HAAO 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0031966mitochondrial membrane IEA--

    HAAO for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for HAAO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011051 RmlC_Cupin
     IPR016700 3hydroanth_dOase_met
     IPR010329 3hydroanth_dOase
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry P46952

    ProtoNet protein and cluster: P46952

    UniProtKB/Swiss-Prot: 3HAO_HUMAN, P46952
    Similarity: Belongs to the 3-HAO family


    HAAO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 3HAO_HUMAN, P46952
    Function: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde,
    which spontaneously cyclizes to quinolinate
    Catalytic activity: 3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde

         Enzyme Number (IUBMB): EC 1.13.11.61 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00003343-hydroxyanthranilate 3,4-dioxygenase activity TAS--
    GO:0005506iron ion binding ----
    GO:0008198ferrous iron binding IDA12007609
    GO:0009055electron carrier activity NAS7514594
    GO:0019825oxygen binding IEA--
         
    HAAO for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HAAO:
     Elongated cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HAAO 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HAAO:
    hsa-miR-647
    SwitchGear 3'UTR luciferase reporter plasmidHAAO 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HAAO About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde0.50
    NAD biosynthesis II (from tryptophan)0.50
    tryptophan degradation III (eukaryotic)0.50
    Tryptophan catabolism0.45
    2Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan metabolism0.46
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4tryptophan utilization II
    tryptophan utilization II0.70
    tryptophan utilization I0.70
    5NAD metabolism
    NAD metabolism0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for HAAO
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for HAAO
        NAD metabolism

    5/6 BioSystems Pathways for HAAO (see all 6)
        tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    Tryptophan metabolism
    NAD biosynthesis II (from tryptophan)
    tryptophan degradation III (eukaryotic)
    tryptophan utilization II


    3        Reactome Pathways for HAAO
        Tryptophan catabolism
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for HAAO):
        Tryptophan metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: 3HAO_HUMAN, P46952
    Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3


    HAAO for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HAAO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/35 Interacting proteins for HAAO (P469522, 3 ENSP000002949734) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGDIAP525652, 3, ENSP000002693214MINT-8257999 I2D: score=2 STRING: ENSP00000269321
    ATXN3P542523, ENSP000003523244I2D: score=1 STRING: ENSP00000352324
    RAD1O606713, ENSP000003408794I2D: score=1 STRING: ENSP00000340879
    GAD1Q992593, ENSP000003509284I2D: score=4 STRING: ENSP00000350928
    URODP061323, ENSP000002463374I2D: score=1 STRING: ENSP00000246337
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006569tryptophan catabolic process TAS--
    GO:0009435NAD biosynthetic process IEA--
    GO:0010043response to zinc ion IDA12007609
    GO:0019805quinolinate biosynthetic process NAS12007609
    GO:0034354'de novo' NAD biosynthetic process from tryptophan ----

    HAAO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HAAO for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HAAO (3HAO)

    4 HMDB Compounds for HAAO    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Amino-3-carboxymuconic acid semialdehydeACS (see all 9)16597-58-3--
    3-Hydroxyanthranilic acid2-Amino-3-hydroxybenzoate (see all 17)548-93-6--
    IronArmco iron (see all 19)7439-89-6--
    OxygenOxygen (see all 5)7782-44-7--

    7 Novoseek inferred chemical compound relationships for HAAO gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-hydroxyanthranilic acid 95 24 9539135 (4), 16522801 (3), 12007609 (2), 7514594 (2) (see all 10)
    quinolinic acid 80 7 12007609 (2), 1825460 (2), 9685612 (1), 1831362 (1) (see all 5)
    kynurenine 74.2 4 16522801 (1), 8906308 (1), 9539135 (1)
    hydroxylamine 71.7 6 15697211 (1), 18761666 (1), 18973625 (1), 2338066 (1) (see all 5)
    quinine 62.8 6 9685612 (1), 7514594 (1)
    hydrazine 50 3 18761666 (1), 18973625 (1)
    polyacrylamide 25.1 1 2338066 (1)

    Search CenterWatch for drugs/clinical trials and news about HAAO / 3HAO

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HAAO gene: 
    NM_012205.2  

    Unigene Cluster for HAAO:

    3-hydroxyanthranilate 3,4-dioxygenase
    Hs.368805  [show with all ESTs]
    Unigene Representative Sequence: NM_012205
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406007 ENST00000294973(uc002rst.4) ENST00000402698 ENST00000404451
    ENST00000431905 ENST00000406924(uc010ynw.1) ENST00000402268
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HAAO:
    hsa-miR-647
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK295693.1 BC029510.1 CR457063.1 Z29481.1 

    5 DOTS entries:

    DT.212090  DT.102823242  DT.99976662  DT.100751508  DT.95159385 

    24/51 AceView cDNA sequences (see all 51):

    CR624693 CB850657 AW615072 BX105135 BI768871 CR457063 AI354294 AI341625 
    BC029510 AI005031 Z29481 BI908552 BQ719546 BM906893 BU732656 BU859616 
    AL554133 BF514377 NM_012205 BI602406 R78903 CD675091 AL576937 AV697461 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HAAO    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                    -                       -           -                                             
    SP2:                                            -           -                                             
    SP3:                    -                       -     -     -           -     -                           
    SP4:                    -                                                                                 
    SP5:                                            -                                                         


    ECgene alternative splicing isoforms for HAAO

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HAAO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCTGGGCG
    HAAO Expression
    About this image


    See HAAO Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HAAO

    SOURCE GeneReport for Unigene cluster: Hs.368805
        SABiosciences Expression via Pathway-Focused PCR Arrays including HAAO: 
              Amino Acid Metabolism I in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HAAO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HAAO gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Haao1 , 5 3-hydroxyanthranilate 3,4-dioxygenase1, 5 85.33(n)1
    85.92(a)1
      17 (54.85 cM)5
    1077661  NM_025325.21  NP_079601.11 
     838313565 
    chicken
    (Gallus gallus)
    Aves HAAO1 3-hydroxyanthranilate 3,4-dioxygenase 61.03(n)
    63.03(a)
      421396  XM_419453.3  XP_419453.3 
    lizard
    (Anolis carolinensis)
    Reptilia HAAO6
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL343231.1(500679-521163)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686442 hypothetical protein MGC68644 76.85(n)    BC061663.1 
    zebrafish
    (Danio rerio)
    Actinopterygii haao1 3-hydroxyanthranilate 3,4-dioxygenase 57.11(n)
    55.56(a)
      492518  NM_001007390.1  NP_001007391.1 
    worm
    (Caenorhabditis elegans)
    Secernentea haao-11 Protein HAAO-1 50.95(n)
    45.41(a)
      179329  NM_073049.1  NP_505450.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BNA1(YJR025C)4
    BNA11
    3-hydroxyanthranilic acid dioxygenase, required for more4
    Bna1p1
    46.93(n)1
    42.76(a)1
      10(471671-471138)4
    8534821, 4  NP_012559.11, 4 


    ENSEMBL Gene Tree for HAAO (if available)
    TreeFam Gene Tree for HAAO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/740 SNPs in HAAO are shown (see all 740)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49536571,2
    C,A--42993782(+) TGAAAC/TCCCCA 1 -- ds500110Minor allele frequency- T:0.22NA WA CSA EA 371
    rs1406759621,2
    --42993953(+) GATCCA/TGTTTC 1 -- ds50010--------
    rs728688341,2
    C--42993994(+) GAGAAC/TAGAGA 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs621454831,2
    C,F--42994024(+) TTAGCC/TGTGCT 1 -- ds50012Minor allele frequency- T:0.08NA 122
    rs1155784401,2
    C,F--42994034(+) TCCCAG/AGACCA 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1851808561,2
    --42994113(+) AATAAC/GAGACC 1 -- ds50010--------
    rs1893926891,2
    --42994159(+) CCCCAG/TACACA 1 -- ds50010--------
    rs1818329681,2
    --42994212(+) GCCTGC/TGGCAG 1 -- ds50010--------
    rs23046591,2
    C,F,H--42994369(+) GTCTGC/TCAGAG 1 -- ut31 ese311Minor allele frequency- T:0.04EA NA NS 2380
    rs23046601,2
    C--42994395(+) TGCCCA/GCCCAG 1 -- ut31 ese30--------

    HapMap Linkage Disequilibrium report for HAAO (42994229 - 43019751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HAAO:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519877CNV Loss19592680
    nsv457152CNV Loss19166990
    nsv817795CNV Gain17921354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604521    OMIM disorders: --

    12 diseases for HAAO:    About MalaCards
    pellagra    conduct disorder    olivopontocerebellar atrophy    transient cerebral ischemia
    cerebritis    huntington's disease    endometrial carcinoma    ischemia
    parkinson's disease    multiple sclerosis    ovarian cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HAAO:
    Pellagra

    HAAO for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): HAAO
    Human Genome Epidemiology (HuGE) Navigator: HAAO (3 documents)

    Export disorders for HAAO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HAAO gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with HAAO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of human 3- hydroxyanthranilic-acid dioxygenase. (PubMed id 7514594)1, 2, 3, 9 Malherbe P.... Cesura A.M. (1994)
    2. Evidence for genes on chromosome 2 contributing to al cohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (2010)
    3. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Cloning of human 3-hydroxyanthranilic acid dioxygenase in Escherichia coli: characterisation of the purified enzyme and its in vitro inhibition by Zn2+. (PubMed id 12007609)1, 9 Calderone V....Zanotti G. (2002)
    7. Identification of candidate epigenetic biomarkers for ovarian cancer detection. (PubMed id 19724865)1, 9 Huang Y.W....Lin H.J. (2009)
    8. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    9. Genome-wide meta-analysis identifies novel multiple sc lerosis susceptibility loci. (PubMed id 22190364)4 Patsopoulos N.A....de Bakker P.I. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23498 HGNC: 4796 AceView: HAAO Ensembl:ENSG00000162882 euGenes: HUgn23498
    ECgene: HAAO Kegg: 23498 H-InvDB: HAAO

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HAAO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HAAO gene:
    Search GeneIP for patents involving HAAO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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