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H6PD Gene

protein-coding GIFtS: 59

GC01P009229

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
(Previous name: glucose dehyrogenase )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GDH)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
6-phosphogluconolactonase ^²
DKFZp686A01246 ^²
G6PDH ^², ⁵
GDH ^², ³, ⁵
MGC87643 ^²
OTTHUMP00000001703 ^²

Descriptions
G6PD, H form ^²
GDH/6PGL endoplasmic bifunctional protein ^²
glucose 1- dehydrogenase ^²
glucose dehydrogenase ^²
glucose dehyrogenase ^¹, ²
glucose-6-phosphate dehydrogenase, salivary ^²
hexose-6-phosphate dehydrogenase ^²
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) ^²

External Ids
HGNC: 4795¹
Entrez Gene: 9563²
UniProtKB: O95479³
Ensembl: ENSG00000049239⁷

Search outside databases for aliases for H6PD gene

Previous GC identifers: GC01P008915 GC01P009105 GC01P009004

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for H6PD:

There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by

this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates,

especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both

forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq]

UniProtKB/Swiss-Prot: G6PE_HUMAN, O95479

Function: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates

Gene Wiki entry for H6PD

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the H6PD gene

Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36

H6PD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P009229: (about GC identifiers)

Start:	9,217,450 bp from pter
End:	9,253,983 bp from pter
Size:	36,534 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_021937.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: G6PE_HUMAN, O95479 (See protein sequence)

Recommended Name: GDH/6PGL endoplasmic bifunctional protein precursor

Size: 791 amino acids; 88893 Da

Subcellular location: Endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen

Secondary accessions: Q4TT33 Q66I35 Q68DT3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004276.2

ENSEMBL proteins:

ENSP00000366620

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (H6PD)
	Human Recombinant Proteins from Abnova (H6PD)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18029348
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005788	endoplasmic reticulum lumen	IEA	--
GO:0005792	microsome	IEA	--

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Antibodies for H6PD:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for H6PD
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (H6PD), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (H6PD)
	Novus Biologicals Antibodies for H6PD

Assays for H6PD:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O95479

ProtoNet protein and cluster: O95479

UniProtKB/Swiss-Prot: G6PE_HUMAN, O95479

Similarity: In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family

Similarity: In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate

isomerase family. 6-phosphogluconolactonase subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (H6PD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (H6PD)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004285

Applied Biosystems Silencer® siRNAs for H6PD

Sigma-Aldrich siRNA for H6PD

Sigma-Aldrich shRNA for H6PD

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for H6PD
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004285
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004285
untagged cDNA clones in CMV expression vector (see all 4): AK024548

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004285

UniProtKB/Swiss-Prot: G6PE_HUMAN, O95479

Function: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates

Catalytic activity: Beta-D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H

Catalytic activity: D-glucose 6-phosphate + NAD(P)(+) = D-glucono-1,5-lactone 6-phosphate + NAD(P)H

Catalytic activity: 6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for H6pd):

endocrine/exocrine gland

homeostasis/metabolism

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004345	glucose-6-phosphate dehydrogenase activity	TAS	10349511
GO:0005488	binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0017057	6-phosphogluconolactonase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for H6PD (Your Favorite Gene powered by Ingenuity)

Glutathione Metabolism
Pentose Phosphate Pathway

GeneDecks H6PD for the pathways selected above

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	IEA	--
GO:0006006	glucose metabolic process	IEA	--
GO:0006098	pentose-phosphate shunt	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for H6PD
10/63 Novoseek chemical compound relationships for H6PD gene (see all 63 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose 6-phosphate	92.79	179	7781912 (2), 9392523 (2), 17137780 (2), 1563647 (1) (see all 99)
pyrroloquinoline quinone	86.14	20	16131222 (2), 10933491 (1), 11225357 (1), 16750941 (1) (see all 10)
11beta-hydroxysteroid	85.51	32	18622204 (4), 18381077 (2), 18963204 (2), 19010388 (2) (see all 19)
o-ethylhydroxylamine	80.77	1	10087986 (1)
no-dimethylhydroxylamine	79.03	2	9137808 (1)
neotetrazolium	77.54	5	7930518 (3), 9306960 (1)
nadph	73.69	44	12858176 (2), 10329961 (2), 17303087 (2), 8466510 (1) (see all 34)
6-phosphogluconate	73.43	13	8470806 (1), 11072071 (1), 1381200 (1), 7781912 (1) (see all 11)
glucose	68.95	261	17365439 (5), 8082531 (4), 16556607 (4), 7764620 (3) (see all 99)
nadp+	63.76	13	9508091 (2), 15774558 (1), 18778749 (1), 16556607 (1) (see all 10)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (H6PD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (H6PD)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004285

Sigma-Aldrich siRNA for H6PD

Sigma-Aldrich shRNA for H6PD

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004285

REFSEQ mRNAs for H6PD gene:

NM_004285.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004285

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004285
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004285
                                 untagged cDNA clones in CMV expression vector (see all 4): AK024548

Additional cDNA sequence:

AJ012590.1 AK024548.1 AK026460.1 AK091191.1 AL832271.1 AL833024.1 AY142148.1 BC007368.2

BC026099.1 BC044256.1 BC069028.1 BC081559.1 BC098450.1 CR749282.1

10 DOTS entries:

DT.40133057 DT.439862 DT.92418967 DT.100783194 DT.100786227 DT.121337152 DT.121337183 DT.86846264

DT.121496200 DT.99974386

24/161 AceView cDNA sequences (see all 161 ):

BU071074 AL707973 BU429746 AI867461 BQ706722 AI744639 AI264583 BQ436379

CD367658 BF744875 AJ012590 NM_004285 BU070635 AL602889 CB989699 BQ671499

CK902392 BQ675151 AK024548 AI362636 CA420503 BC044256 AA609834 AL041815

highest scoring ESTs for H6PD:

AA625448 AJ012590 AA333441 AA780061 AA831268 AI077979 AI241305 AI264583 AI274342 AI281221

Unigene Cluster for H6PD:

Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

Hs.463511 [show with all ESTs]

Unigene Representative Sequence: NM_004285

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000377403

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

H6PD expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for H6PD

¹ / ² / ³

11 probe-sets matching H6PD gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
43056_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.02	AA780061	0.80	1.00	0.91	1
82958_at²^{, 3}	U95-E	1	1.00	1.00	0.74	0.65	AA625448	1.00	1.00	1.00	1
34066_at²^{, 3}	U95-A	1	1.00	1.00	0.63	1.09	AJ012590	1.00	1.00	1.00	1
49395_at²^{, 3}	U95-B	1	1.00	1.00	0.46	1.00	AI633514	0.80	1.00	0.91	1
63802_at²^{, 3}	U95-C	1	1.00	1.00	0.73	1.24	AL041815	0.80	1.00	0.91	1
226160_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW138757	0.60	1.00	0.82	1
206933_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004285	0.60	1.00	0.82	1
221892_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK024548	0.60	1.00	0.82	1
226160_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206933_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221892_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks H6PD for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTGGCCAGA

SOURCE GeneReport for Unigene cluster: Hs.463511
Expression variation in blood from EXPOLDB for H6PD
UniProtKB/Swiss-Prot: G6PE_HUMAN, O95479
Tissue specificity: Present in most tissues examined, strongest in liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for H6PD gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	H6PD¹	--	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	86.97(n) 85.15(a)	489642 XM_546762.2 XP_546762.2
cow (Bos taurus)	H6PD¹	--	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	85.5(n) 83.94(a)	541220 XM_615112.3 XP_615112.3
rat (Rattus norvegicus)	H6pd¹	--	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	83.31(n) 83.06(a)	298655 XM_233688.4 XP_233688.4
mouse (Mus musculus)	H6pd^{1, 5}	4 (78.40 cM)⁵	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)^{1, 5}	83.78(n)¹ 83.69(a)¹	100198¹ NM_173371.3¹ NP_775547.2¹ AA939571⁵ AI785303⁵ (see all 21)
chicken (Gallus gallus)	H6PD¹	--	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	70.73(n) 70.09(a)	428188 XM_425746.2 XP_425746.2

About this table Species with no ortholog for H6PD

ENSEMBL Gene Tree for H6PD

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for H6PD gene

G6PD² PGLS²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/240 NCBI SNPs in H6PD are shown (see all 240 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 100)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1294014^1,2	A,C,F,H,O	9248263(+)	`AAAGAC/TTAGAC`	1	--	ut3¹ ese³		14	MN EA NA EU WA	1408
	rs6688832^1,2	A,C,F,H	9246497(+)	`TGTGCA/GGGAGC`	1	R/Q	mis¹ ese³		17	EA NA EU WA	1544
	rs1294015^1,2	A,C,F,H	9249974(+)	`GCCCCT/GATCCC`	1	--	ut3¹ ese³		10	EA NA MN EU WA	1758
	rs11121354^1,2	A,C,F,H	9250000(+)	`GGATTT/GCATTT`	1	--	ut3¹		16	EU EA WA	1678
	rs11807816^1,2	A,C,F,H	9248254(+)	`TACAGT/CGGCAA`	1	--	ut3¹ ese³		4	EU EA WA	380
--	rs11121356^1,2	C,F,H	9253066(+)	`CGTTAC/TGGGGC`	1	--	ut3¹ ese³		7	NA EU EA WA	560
	rs2071931^1,2	C,F,H	9251876(-)	`TAAGCG/AGCCCC`	1	--	ut3¹ ese³		5	EU EA WA	598
	rs17368528^1,2	C,F,H	9246800(+)	`GAGCCC/TGCTGG`	1	P/L	mis¹ ese³		13	NA EA EU WA	1112
--	rs7514387^1,2	A,C,F	9254216(+)	`TGATCG/TCATTT`	1	--	ng3¹		5	EA NA	396
--	rs12314^1,2	A,C,F	9250536(+)	`TCTTAA/CCCTTA`	1	--	ut3¹		3	MN EA	550

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HapMap Linkage Disequilibrium images for H6PD (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 138090 disorders: 604931

UniProtKB/Swiss-Prot: G6PE_HUMAN, O95479

Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD,

activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated

androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS)

10/30 Novoseek disease relationships for H6PD gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cortisone reductase deficiency	93.81	9	15956339 (1), 17062770 (1), 16091483 (1), 17240046 (1) (see all 8)
enzymopathy	66.23	4	16987707 (1), 15555758 (1), 16118620 (1), 7984573 (1)
enzyme deficiency	22.21	1	7984573 (1)
polycystic ovary syndrome	19.27	2	15827106 (1)
obesity	19.00	1	18622204 (1)
insulin resistance	16.36	1	14502105 (1)
metastasis	3.33	3	7930518 (2), 10440855 (1)
hypoglycemia	3.30	1	17365439 (1)
inflammation	2.89	1	15177053 (1)
tumors	0.50	2	1381200 (1), 17303087 (1)

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Human Gene Mutation Database: H6PD
Genetic Association Database: H6PD
Human Genome Epidemiology Navigator: H6PD (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/314 PubMed articles for H6PD gene (see all 314 ):

Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) encoded at 1p36: coding sequence and expression. (PubMed id 10349511)^{1, 2, 3, 4} Mason P.J....Vulliamy T.J. (1999)
Genotypes at 11beta-hydroxysteroid dehydrogenase type 11B1 and hexose-6-phosphate dehydrogenase loci are not risk factors for apparent cortisone reductase deficiency in a large population-based sample. (PubMed id 16091483)^{1, 3, 6} White P.C. (2005)
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. (PubMed id 12858176)^{1, 3, 4} Draper N....Stewart P.M. (2003)
A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome. (PubMed id 15827106)^{1, 3, 6} San Millan J.L....Escobar-Morreale H.F. (2005)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Constant expression of hexose-6-phosphate dehydrogenase during differentiation of human adipose-derived mesenchymal stem cells. (PubMed id 18586838)^{1, 3} Senesi S....Benedetti A. (2008)
Adipose tissue 11-beta-Hydroxysteroid Dehydrogenase Type 1 and Hexose-6-Phosphate Dehydrogenase gene expressions are increased in patients with type 2 diabetes mellitus. (PubMed id 18963204)^{1, 3} UAskaya G....Kutlu M. (2008)
Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1. (PubMed id 19010388)^{1, 3} BalA!zs Z....Odermatt A. (2009)
H6PDH interacts directly with 11beta-HSD1: implications for determining the directionality of glucocorticoid catalysis. (PubMed id 19121282)^{1, 3} Zhang Y.L....Suri V. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9563	HGNC: 4795	AceView: H6PD	Ensembl:ENSG00000049239	euGenes: HUgn9563
ECgene: H6PD	H-InvDB: H6PD

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for H6PD	Genetics and Cytogenetics in Oncology and Haematology
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=H6PD

Licensable Technologies for H6PD
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for H6PD:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for H6PD-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for H6PD		Antibodies for H6PD
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for H6PD		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Antibodies for H6PD

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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H6PD Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for H6PD

Summaries
for H6PD

Genomic Location
for H6PD

Proteins
for H6PD

Protein Domains/
Families
for H6PD

Gene Function
for H6PD

Pathways & Interactions
for H6PD

Drugs & Compounds
for H6PD

Transcripts
for H6PD

Expression
for H6PD

Orthologs
for H6PD

Paralogs
for H6PD

SNPs/Variants
for H6PD

Disorders & Mutations
for H6PD

Medical News
for H6PD

Publications
for H6PD

Search for H6PD

Genome Databases showing H6PD

Other Databases showing H6PD

Specialized Databases showing H6PD

Licensable Technologies
for H6PD

Services
for H6PD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

H6PD Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor H6PD

Summariesfor H6PD

Genomic Locationfor H6PD

Proteinsfor H6PD

Protein Domains/Familiesfor H6PD

Gene Functionfor H6PD

Pathways & Interactionsfor H6PD

Drugs & Compoundsfor H6PD

Transcriptsfor H6PD

Expression for H6PD

Orthologsfor H6PD

Paralogsfor H6PD

SNPs/Variantsfor H6PD

Disorders & Mutationsfor H6PD

Medical Newsfor H6PD

Publicationsfor H6PD

Search for H6PD

Genome Databases showing H6PD

Other Databases showing H6PD

Specialized Databases showing H6PD

Licensable Technologiesfor H6PD

Servicesfor H6PD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for H6PD

Summaries
for H6PD

Genomic Location
for H6PD

Proteins
for H6PD

Protein Domains/
Families
for H6PD

Gene Function
for H6PD

Pathways & Interactions
for H6PD

Drugs & Compounds
for H6PD

Transcripts
for H6PD

Expression
for H6PD

Orthologs
for H6PD

Paralogs
for H6PD

SNPs/Variants
for H6PD

Disorders & Mutations
for H6PD

Medical News
for H6PD

Publications
for H6PD

Licensable Technologies
for H6PD

Services
for H6PD