Aliases for H3F3C Gene
External Ids for H3F3C Gene
Previous GeneCards Identifiers for H3F3C Gene
GeneCards Summary for H3F3C Gene
H3F3C (H3 Histone, Family 3C) is a Protein Coding gene. Diseases associated with H3F3C include corneal granular dystrophy and lattice corneal dystrophy. Among its related pathways are Transcriptional misregulation in cancer and RNA Polymerase I Promoter Opening. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST2H3A.
UniProtKB/Swiss-Prot for H3F3C Gene
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.