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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

H3F3C Gene

protein-coding   GIFtS: 47
GCID: GC12M031944

H3 histone, family 3C

 Explore 6 diseases affiliated with
H3F3C via our new
 Human Malady Compendium 
Biological research products
for H3F3C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
H3 Histone, Family 3C1 2
H3.51 2
Histone H3.52 3
Histone H3.3C2
Histone Variant H3.52

External Ids:    HGNC: 331641   Entrez Gene: 4400932   Ensembl: ENSG000001883757   UniProtKB: Q6NXT23   

Export aliases for H3F3C gene to outside databases

Previous GC identifers: GC12M031838 GC12M031696


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: H3C_HUMAN, Q6NXT2
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific
H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for H3F3C
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for H3F3C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H3F3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.21   Ensembl cytogenetic band:  12p11.21   HGNC cytogenetic band: 12p11.21

H3F3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H3F3C gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M031944:  view genomic region     (about GC identifiers)

Start:
31,944,119 bp from pter      End:
31,945,175 bp from pter
Size:
1,057 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H3C_HUMAN, Q6NXT2 (See protein sequence)
Recommended Name: Histone H3.3C  
Size: 135 amino acids; 15214 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
1 PDB 3D structure from and Proteopedia for H3F3C:
3KV4 (3D)    
Secondary accessions: E9P281

Explore the universe of human proteins at neXtProt for H3F3C: NX_Q6NXT2

Post-translational modifications:

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
  • (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me) (By
    similarity)1
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription (By
  • similarity)1
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9
  • (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to
    gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the
    3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on
    active promoters (By similarity)1
  • Methylation at Lys-5 (H3K4me) is linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent
  • acetylation of H3 and H4. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression.
    Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent
    phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) requires preliminary
    monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X
    chromosome chromatin. Monomethylation at Lys-56 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and
    is required for DNA replication (By similarity)1
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation
  • at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and
    meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because
    it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV
    irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which
    is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from
    heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell
    transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon
    ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional
    activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at
    Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a
    specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.
    Phosphorylation at Tyr-41 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity)1
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes
  • place on H3K4me3 and results in gene repression (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6NXT2

  • H3F3C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001013721.2  
    ENSEMBL proteins: 
     ENSP00000339835  

    Human Recombinant Protein Products: 
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    Uscn Proteins for H3F3C

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IEA--


    H3F3C for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    H3F3C for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q6NXT2

    ProtoNet protein and cluster: Q6NXT2

    1 Blocks protein family: IPB000164 Histone H3

    UniProtKB/Swiss-Prot: H3C_HUMAN, Q6NXT2
    Similarity: Belongs to the histone H3 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: H3C_HUMAN, Q6NXT2
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific
    H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--


    H3F3C for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Systemic lupus erythematosus
    Systemic lupus erythematosus1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for H3F3C):
        Systemic lupus erythematosus


    H3F3C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H3F3C

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for H3F3C (ENSP000003398354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    SUMO1ENSP000003760764STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--


    H3F3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for H3F3C:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for H3F3C
    Search CenterWatch for drugs/clinical trials and news about H3F3C / H3C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for H3F3C gene: 
    NM_001013699.2  

    Unigene Cluster for H3F3C:

    H3 histone, family 3C
    Hs.448697  [show with all ESTs]
    Unigene Representative Sequence: BM458099
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340398(uc001rkr.3)

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    Additional cDNA sequence: 

    BC066906.1 HQ873957.1 

    24/25 DOTS entries (see all 25):

    DT.91778033  DT.100706984  DT.100707000  DT.100706978  DT.91778022  DT.91778014  DT.91778028  DT.100837098 
    DT.91986813  DT.120913319  DT.100706990  DT.100058702  DT.120913335  DT.92325522  DT.120913421  DT.100706970 
    DT.100706973  DT.100707005  DT.120913351  DT.120913360  DT.120913371  DT.120913380  DT.120913382  DT.120913390 

    16 AceView cDNA sequences:

    BI460089 BC066906 BU070615 BM679989 BF689001 AI016942 BM857423 BU734424 
    BE250406 AW162692 BU730662 BG683958 BQ268688 N52499 BQ268816 CB218266 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    H3F3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCTGTATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See H3F3C Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.448697

    UniProtKB/Swiss-Prot: H3C_HUMAN, Q6NXT2
    Tissue specificity: Specifically expressed in the seminiferous tubules of testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for H3F3C gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves H33_CHICK6
    H32_CHICK6
    Histone H3.2
    96(a)
    90(a)
    possible ortholog
    possible ortholog
    18(4698469-4700929)
    1(49952774-49953202)
    lizard
    (Anolis carolinensis)
    Reptilia H3F3A6
    --
    96(a)
    possible ortholog
    2(113660699-113662126)
    zebrafish
    (Danio rerio)
    Actinopterygii h3f3a6
    h3f3d6
    (see all 3)
    H3 histone, family 3D
    (see all 3)
    96(a)
    96(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3(45814483-45816236)
    24(39191743-39196042)
    fruit fly
    (Drosophila melanogaster)
    Insecta His3.3B6
    His3.3A6
    Histone H3.3A
    96(a)
    96(a)
    possible ortholog
    possible ortholog
    X(9046556-9050721)
    2L(5055058-5056149)
    worm
    (Caenorhabditis elegans)
    Secernentea his-716
    Histone H3.3 type 1
    95(a)
    possible ortholog
    X(7981333-7982027)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G103906
    AT5G104006
    (see all 6)
    histone H3
    (see all 6)
    92(a)
    92(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    5(3268847-3269550)
    5(3270289-3270952)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 6)
    histone H3, putative, expressed
    (see all 6)
    92(a)
    92(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    6(3039093-3040122)
    1(37512703-37513521)
            Species with no ortholog for H3F3C

    ENSEMBL Gene Tree for H3F3C (if available)
    TreeFam Gene Tree for H3F3C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for H3F3C gene
    HIST2H3C2  HIST1H3A2  HIST1H3B2  HIST1H3J2  HIST1H3E2  HIST2H3D2  HIST1H3D2  HIST1H3H2  
    HIST3H32  H3F3A2  HIST1H3F2  HIST1H3I2  HIST1H3G2  HIST1H3C2  H3F3B2  HIST2H3A2  
    18 SIMAP similar genes for H3F3C using alignment to 1 protein entry:     H3C_HUMAN:
    H3F3A    H3F3B    HIST2H3A    HIST2H3C    HIST2H3D    HIST1H3A
    HIST1H3B    HIST1H3C    HIST1H3D    HIST1H3E    HIST1H3F    HIST1H3G
    HIST1H3H    HIST1H3I    HIST1H3J    HIST3H3    HIST2H3PS2    CENPA

    H3F3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/81 NCBI SNPs in H3F3C are shown (see all 81    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17977381,2
    C,F,A,H,--31943705(-) TCTGCT/CGGTTA 1 -- ds500124Minor allele frequency- C:0.18NS EA NA WA CSA 2352
    rs1405091061,2
    --31943720(+) CAGTGA/GGCTAG 1 -- ds50010--------
    rs1853801271,2
    --31943853(+) ACACAA/GTGAAA 1 -- ds50010--------
    rs1175951921,2
    F,--31943955(+) GTTAGT/CGTTTC 1 -- ds50011Minor allele frequency- C:0.09EA 120
    rs348451381,2
    C,--31944218(+) TTTAAT/-TTTTT 1 -- ut311Minor allele frequency- -:0.00NA 2
    rs1898603741,2
    --31944321(+) GACTTA/TACAGC 1 -- ut310--------
    rs360586871,2
    C,F,--31944332(+) CCCAAC/TTGTTA 1 -- ut312Minor allele frequency- T:0.50NA 4
    rs1422612231,2
    --31944431(+) CAAGTC/TATTAA 1 -- ut310--------
    rs110515951,2
    C,F,A,H,--31944475(+) TATCAC/TGCATC 1 -- ut3120Minor allele frequency- T:0.13NS EA NA WA CSA 2344
    rs1129076601,2
    C,--31944476(+) ATCACG/ACATCC 1 -- ut312Minor allele frequency- A:0.04NA 122

    HapMap Linkage Disequilibrium report for H3F3C (31944119 - 31945175 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for H3F3C: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    H3F3C for disorders           About GeneDecksing

    6 diseases for H3F3C:    About MalaCards
    lattice corneal dystrophy    corneal granular dystrophy    corneal dystrophy    systemic lupus erythematosus
    lupus erythematosus    malaria

    2 diseases from the University of Copenhagen DISEASES database for H3F3C:
    Corneal granular dystrophy     Lattice corneal dystrophy

    Export disorders for H3F3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for H3F3C gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with H3F3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. H3.5 is a novel hominid-specific histone H3 variant that is specifically expressed in the seminiferous tubules of human testes. (PubMed id 21274551)1, 2, 3 Schenk R.... Postberg J. (2011)
    2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
    7. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (2010)
    8. Quantitative interaction proteomics and genome-wide p rofiling of epigenetic histone marks and their readers. (PubMed id 20850016)2 Vermeulen M....Mann M. (2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting. (PubMed id 17925393)1 Holbert M.A....Marmorstein R. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440093 HGNC: 33164 AceView: LOC440093 Ensembl:ENSG00000188375 euGenes: HUgn440093
    ECgene: H3F3C Kegg: 440093 H-InvDB: H3F3C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for H3F3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for H3F3C gene:
    Search GeneIP for patents involving H3F3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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