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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

H3F3C Gene

protein-coding   GIFtS: 46
GCID: GC12M031944

H3 Histone, Family 3C

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
H3 Histone, Family 3C1 2
Histone H3.52 3
H3.52
Histone H3.3C2
Histone Variant H3.52

External Ids:    HGNC: 331641   Entrez Gene: 4400932   Ensembl: ENSG000001883757   UniProtKB: Q6NXT23   

Export aliases for H3F3C gene to outside databases

Previous GC identifers: GC12M031838 GC12M031696


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for H3F3C Gene: 
H3F3C (H3 histone, family 3C) is a protein-coding gene. Diseases associated with H3F3C include corneal granular dystrophy, and lattice corneal dystrophy, and among its related super-pathways are Systemic lupus erythematosus. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST2H3D.

UniProtKB/Swiss-Prot: H3C_HUMAN, Q6NXT2
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is
associated with actively transcribed genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for H3F3C
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for H3F3C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H3F3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.21   Ensembl cytogenetic band:  12p11.21   HGNC cytogenetic band: 12p11.21

H3F3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H3F3C gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M031944:  view genomic region     (about GC identifiers)

Start:
31,944,119 bp from pter      End:
31,945,175 bp from pter
Size:
1,057 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H3C_HUMAN, Q6NXT2 (See protein sequence)
Recommended Name: Histone H3.3C  
Size: 135 amino acids; 15214 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
1 PDB 3D structure from and Proteopedia for H3F3C:
3KV4 (3D)    
Secondary accessions: E9P281

Explore the universe of human proteins at neXtProt for H3F3C: NX_Q6NXT2

Explore proteomics data for H3F3C at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me) (By
    similarity)
  • UniProtKB: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription
    (By similarity)
  • UniProtKB: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at
    Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is
    linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is
    present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while
    it is absent on active promoters (By similarity)
  • UniProtKB: Methylation at Lys-5 (H3K4me) is linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent
    acetylation of H3 and H4. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression.
    Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents
    subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me)
    requires preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me)
    are enriched in inactive X chromosome chromatin. Monomethylation at Lys-56 (H3K56me1) by EHMT2/G9A in G1 phase
    promotes interaction with PCNA and is required for DNA replication (By similarity)
  • UniProtKB: Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression
    during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important
    during interphase because it enables the transcription of genes following external stimulation, like mitogens,
    stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun.
    Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me)
    but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation
    of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an
    essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK
    isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph)
    by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5
    (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early
    anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic
    transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at
    Tyr-41 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity)
  • UniProtKB: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only
    takes place on H3K4me3 and results in gene repression (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6NXT2

  • H3F3C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    H3F3C Protein Expression
    REFSEQ proteins: NP_001013721.2  
    ENSEMBL proteins: 
     ENSP00000339835  

    Human Recombinant Protein Products for H3F3C: 
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    Novus Biologicals H3F3C Protein
    Novus Biologicals H3F3C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for H3F3C 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IEA--

    H3F3C for ontologies           About GeneDecksing



    H3F3C Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RIH: Histones / Replication-independent

    3 InterPro protein domains:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q6NXT2

    ProtoNet protein and cluster: Q6NXT2

    1 Blocks protein domain: IPB000164 Histone H3

    UniProtKB/Swiss-Prot: H3C_HUMAN, Q6NXT2
    Similarity: Belongs to the histone H3 family


    H3F3C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H3C_HUMAN, Q6NXT2
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is
    associated with actively transcribed genes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    H3F3C for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for H3F3C About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3         Kegg Pathways  (Kegg details for H3F3C):
        Alcoholism
    Transcriptional misregulation in cancer
    Systemic lupus erythematosus


    H3F3C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H3F3C

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for H3F3C (ENSP000003398354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    SUMO1ENSP000003760764STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    H3F3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for H3F3C:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for H3F3C (H3C)

    Search CenterWatch for drugs/clinical trials and news about H3F3C / H3C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for H3F3C gene: 
    NM_001013699.2  

    Unigene Cluster for H3F3C:

    H3 histone, family 3C
    Hs.448697  [show with all ESTs]
    Unigene Representative Sequence: BM458099
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340398(uc001rkr.3)
    miRNA
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    Additional mRNA sequence: 

    BC066906.1 HQ873957.1 

    24/25 DOTS entries (see all 25):

    DT.91778033  DT.100706984  DT.100707000  DT.100706978  DT.91778022  DT.91778014  DT.91778028  DT.100837098 
    DT.91986813  DT.120913319  DT.100706990  DT.100058702  DT.120913335  DT.92325522  DT.120913421  DT.100706970 
    DT.100706973  DT.100707005  DT.120913351  DT.120913360  DT.120913371  DT.120913380  DT.120913382  DT.120913390 

    16 AceView cDNA sequences:

    BI460089 BC066906 BM679989 BF689001 AI016942 BU070615 BU730662 BM857423 
    BG683958 AW162692 BU734424 BE250406 BQ268688 BQ268816 N52499 CB218266 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    H3F3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTGTATG
    H3F3C Expression
    About this image


    See H3F3C Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.448697

    UniProtKB/Swiss-Prot: H3C_HUMAN, Q6NXT2
    Tissue specificity: Specifically expressed in the seminiferous tubules of testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for H3F3C gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii h3f3c6
    H3 histone, family 3C
    96(a)
    1 ↔ 1
    15(46780326-46787157)
    fruit fly
    (Drosophila melanogaster)
    Insecta His3.3A6
    His3.3B6
    Histone H3.3B
    96(a)
    96(a)
    many ↔ many
    many ↔ many
    2L(5055058-5056149)
    X(9046556-9050721)
    worm
    (Caenorhabditis elegans)
    Secernentea his-716
    his-746
    Histone H3.3-like type 2
    95(a)
    89(a)
    possible ortholog
    possible ortholog
    X(7981381-7982075)
    V(12659705-12660330)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CSE4(YKL049C)4 Centromere protein that resembles histone H3, required more   --   11(346764-346075) 853817  NP_012875.2 
            Species with no ortholog for H3F3C

    ENSEMBL Gene Tree for H3F3C (if available)
    TreeFam Gene Tree for H3F3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for H3F3C gene
    HIST2H3D2  HIST1H3D2  HIST2H3C2  HIST1H3H2  HIST1H3A2  HIST3H32  H3F3A2  HIST1H3F2  
    HIST1H3G2  HIST1H3I2  HIST1H3B2  HIST1H3C2  HIST1H3J2  H3F3B2  HIST1H3E2  HIST2H3A2  
    18 SIMAP similar genes for H3F3C using alignment to 1 protein entry:     H3C_HUMAN:
    H3F3A    H3F3B    HIST2H3A    HIST2H3C    HIST2H3D    HIST1H3A
    HIST1H3B    HIST1H3C    HIST1H3D    HIST1H3E    HIST1H3F    HIST1H3G
    HIST1H3H    HIST1H3I    HIST1H3J    HIST3H3    HIST2H3PS2    CENPA

    H3F3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/107 SNPs in H3F3C are shown (see all 107)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17977381,2
    C,F,A,H--31943705(-) TCTGCT/CGGTTA 1 -- ds500124Minor allele frequency- C:0.18NS EA NA WA CSA 2352
    rs1405091061,2
    --31943720(+) CAGTGA/GGCTAG 1 -- ds50010--------
    rs1853801271,2
    --31943853(+) ACACAA/GTGAAA 1 -- ds50010--------
    rs1175951921,2
    C,F--31943955(+) GTTAGT/CGTTTC 1 -- ds50011Minor allele frequency- C:0.09EA 120
    rs348451381,2
    C--31944218(+) TTTAAT/-TTTTT 1 -- ut311Minor allele frequency- -:0.00NA 2
    rs1898603741,2
    --31944321(+) GACTTA/TACAGC 1 -- ut310--------
    rs360586871,2
    C,F--31944332(+) CCCAAC/TTGTTA 1 -- ut312Minor allele frequency- T:0.50NA 4
    rs1422612231,2
    C--31944431(+) CAAGTC/TATTAA 1 -- ut310--------
    rs110515951,2
    C,F,A,H--31944475(+) TATCAC/TGCATC 1 -- ut3120Minor allele frequency- T:0.13NS EA NA WA CSA 2344
    rs1129076601,2
    C,F--31944476(+) ATCACG/ACATCC 1 -- ut312Minor allele frequency- A:0.04NA 122

    HapMap Linkage Disequilibrium report for H3F3C (31944119 - 31945175 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for H3F3C:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv663CNV Loss18451855
    nsv523907CNV Loss19592680
    nsv522362CNV Loss19592680
    nsv519112CNV Loss19592680
    nsv898966CNV Gain21882294
    nsv8940CNV Gain18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    7 diseases for H3F3C:    About MalaCards
    corneal granular dystrophy    lattice corneal dystrophy    corneal dystrophy    monocytic leukemia
    systemic lupus erythematosus    lupus erythematosus    leukemia

    2 diseases from the University of Copenhagen DISEASES database for H3F3C:
    Corneal granular dystrophy     Lattice corneal dystrophy

    H3F3C for disorders           About GeneDecksing


    Export disorders for H3F3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for H3F3C gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with H3F3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. H3.5 is a novel hominid-specific histone H3 variant that is specifically expressed in the seminiferous tubules of human testes. (PubMed id 21274551)1, 2, 3 Schenk R.... Postberg J. (2011)
    2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
    10. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440093 HGNC: 33164 AceView: LOC440093 Ensembl:ENSG00000188375 euGenes: HUgn440093
    ECgene: H3F3C Kegg: 440093 H-InvDB: H3F3C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for H3F3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for H3F3C gene:
    Search GeneIP for patents involving H3F3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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