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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

H3F3B Gene

protein-coding   GIFtS: 61
GCID: GC17M073749

H3 Histone, Family 3B (H3.3B)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
H3 Histone, Family 3B (H3.3B)1 2
H3.3B2 3
H3 Histone, Family 3A2
Histone H3.32
H3.3A3
H3F33

External Ids:    HGNC: 47651   Entrez Gene: 30212   Ensembl: ENSG000001324757   OMIM: 6010585   UniProtKB: P842433   

Export aliases for H3F3B gene to outside databases

Previous GC identifers: GC17M076798 GC17M074237 GC17M074371 GC17M074372 GC17M071284 GC17M069198


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for H3F3B Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene contains introns and its mRNA is poyadenylated, unlike most histone genes. The protein encoded is a
member of the histone H3 family. (provided by RefSeq, Jul 2008)

GeneCards Summary for H3F3B Gene: 
H3F3B (H3 histone, family 3B (H3.3B)) is a protein-coding gene. Diseases associated with H3F3B include retinoblastoma, and systemic lupus erythematosus, and among its related super-pathways are Signal transduction Activin A signaling regulation and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST2H3D.

UniProtKB/Swiss-Prot: H33_HUMAN, P84243
Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes.
Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin
independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes,
suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and
compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a
template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and
chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of
histones, also called histone code, and nucleosome remodeling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the H3F3B gene promoter:
         Sox5   AML1a   Bach2   Arnt   Egr-4   Pax-3   HSF2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidH3F3B promoter sequence
   Search SABiosciences Chromatin IP Primers for H3F3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H3F3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

H3F3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H3F3B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M073749:  view genomic region     (about GC identifiers)

Start:
73,772,515 bp from pter      End:
73,781,974 bp from pter
Size:
9,460 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H33_HUMAN, P84243 (See protein sequence)
Recommended Name: Histone H3.3  
Size: 136 amino acids; 15328 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with
HIRA, a chaperone required for its incorporation into nucleosomes
Subcellular location: Nucleus. Chromosome
Developmental stage: Expressed throughout the cell cycle independently of DNA synthesis
Sequence caution: Sequence=CAH73371.1; Type=Erroneous gene model prediction;
6/24 PDB 3D structures from and Proteopedia for H3F3B (see all 24):
2L43 (3D)        3ASK (3D)        3ASL (3D)        3AV2 (3D)        3JVK (3D)        3MUK (3D)    
Secondary accessions: P06351 P33155 Q5VV55 Q5VV56 Q66I33 Q9V3W4

Explore the universe of human proteins at neXtProt for H3F3B: NX_P84243

Explore proteomics data for H3F3B at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me)
  • UniProtKB: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription
  • UniProtKB: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at
    Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is
    linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is
    present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while
    it is absent on active promoters
  • UniProtKB: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me),
    Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at
    Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1.
    Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented.
    Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents
    subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and
    Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and
    Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by
    EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication
  • UniProtKB: Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression
    during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important
    during interphase because it enables the transcription of genes following external stimulation, like mitogens,
    stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun.
    Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me)
    but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation
    of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an
    essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK
    isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph)
    by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5
    (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early
    anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic
    transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at
    Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32
    (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes
  • UniProtKB: Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination
    (By similarity)
  • UniProtKB: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only
    takes place on H3K4me3 and results in gene repression (PubMed:22483618)
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P84243

  • H3F3B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    H3F3B Protein Expression
    REFSEQ proteins: NP_005315.1  
    ENSEMBL proteins: 
     ENSP00000254810   ENSP00000467165   ENSP00000466663   ENSP00000468714   ENSP00000465813  
     ENSP00000466020   ENSP00000465403   ENSP00000468484  
    Reactome Protein details: P84243
    Human Recombinant Protein Products for H3F3B: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for H3F3B
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    Novus Biologicals H3F3B Proteins
    Novus Biologicals H3F3B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for H3F3B 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005576extracellular region TAS--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    H3F3B for ontologies           About GeneDecksing



    H3F3B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of H3F3B
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    Novus Biologicals H3F3B Antibodies
    Abcam antibodies for H3F3B
    Cloud-Clone Corp. Antibodies for H3F3B 
    ThermoFisher Antibody for H3F3B
    LSBio Antibodies in human, mouse, rat for H3F3B 

    Assay Products for H3F3B: 
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    Cloud-Clone Corp. ELISAs for H3F3B 
    Cloud-Clone Corp. CLIAs for H3F3B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RIH: Histones / Replication-independent

    3 InterPro protein domains:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P84243

    ProtoNet protein and cluster: P84243

    UniProtKB/Swiss-Prot: H33_HUMAN, P84243
    Similarity: Belongs to the histone H3 family


    H3F3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H33_HUMAN, P84243
    Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes.
    Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin
    independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes,
    suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and
    compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a
    template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and
    chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of
    histones, also called histone code, and nucleosome remodeling

         Genatlas biochemistry entry for H3F3B:
    histone family 3,replacement subtype,replication independent protein,species H3.3B

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI19494831
    GO:0046982protein heterodimerization activity IEA--
         
    H3F3B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for H3f3b):
     cellular  embryogenesis  growth/size  mortality/aging  normal 
     reproductive system 

    H3F3B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out H3f3btm1.1Psk for H3F3B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for H3F3B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for H3F3B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for H3F3B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for H3F3B 

    miRNA
    Products:
        
    miRTarBase miRNAs that target H3F3B:
    hsa-mir-1 (MIRT002794)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H3F3B
    8/124 QIAGEN miScript miRNA Assays for microRNAs that regulate H3F3B (see all 124):
    hsa-miR-188-5p hsa-miR-938 hsa-miR-605 hsa-miR-128 hsa-miR-374a hsa-miR-890 hsa-miR-208b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidH3F3B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: H3F3B (NM_005324)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H3F3B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for H3F3B About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.54
    3Meiotic Synapsis
    Meiosis0.70
    Meiotic Recombination0.62
    4UVA-Induced MAPK Signaling
    UVB-Induced MAPK Signaling0.38
    UVA-Induced MAPK Signaling0.38
    5Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for H3F3B (see all 6)
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Cell cycle Chromosome condensation in prometaphase

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for H3F3B (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    PKA Signaling
    UVB-Induced MAPK Signaling
    Interferon Pathway
    Crosstalk Between CARM1 and ESRs

    5 GeneGo (Thomson Reuters) Pathways for H3F3B
        Cell cycle Chromosome condensation in prometaphase
    Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    1 BioSystems Pathway for H3F3B
        Gastric cancer network 1

    5/6        Reactome Pathways for H3F3B (see all 6)
        Amyloids
    Hemostasis
    Factors involved in megakaryocyte development and platelet production
    Meiosis
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for H3F3B):
        Alcoholism
    Transcriptional misregulation in cancer
    Systemic lupus erythematosus


    H3F3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H3F3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/306 Interacting proteins for H3F3B (P842432, 3 ENSP000002548104) via UniProtKB, MINT, STRING, and/or I2D (see all 306)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PELP1Q8IZL82, 3MINT-7903569 MINT-7903490 MINT-7903524 MINT-7903607 MINT-7903554 MINT-7903511 MINT-7903461 MINT-7903594 MINT-7903394 MINT-7903444 MINT-7903429 I2D: score=1 
    HIST1H4BP628053, ENSP000003665814I2D: score=23 STRING: ENSP00000366581
    HIST1H4AP628053I2D: score=23 
    HIST1H4CP628053I2D: score=23 
    HIST1H4DP628053I2D: score=23 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0007420brain development IEA--
    GO:0007596blood coagulation TAS--
    GO:0009725response to hormone stimulus IEA--

    H3F3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for H3F3B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for H3F3B (H33)

    Search CenterWatch for drugs/clinical trials and news about H3F3B / H33

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for H3F3B gene: 
    NM_005324.3  

    Unigene Cluster for H3F3B:

    H3 histone, family 3B (H3.3B)
    Hs.180877  [show with all ESTs]
    Unigene Representative Sequence: BX537379
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254810(uc002jpl.3) ENST00000593254 ENST00000586518 ENST00000592643
    ENST00000591890 ENST00000589949 ENST00000587560 ENST00000589599 ENST00000586607
    ENST00000586270 ENST00000587171 ENST00000589417 ENST00000591893
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H3F3B
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    Additional mRNA sequence: 

    AF218029.1 AK054591.1 AK130772.1 AK304607.1 AK312762.1 BC001124.2 BC006497.2 BC012813.2 
    BC017558.1 BC020466.1 BC108701.1 BX537379.1 BX647280.1 

    24/86 DOTS entries (see all 86):

    DT.91778033  DT.100706978  DT.91778014  DT.91778022  DT.91778028  DT.100706984  DT.100837098  DT.100707000 
    DT.120913319  DT.92325522  DT.100706983  DT.120913311  DT.120913435  DT.102839701  DT.100706990  DT.100706989 
    DT.87017903  DT.91986813  DT.100706982  DT.100058702  DT.100707002  DT.120913371  DT.40115786  DT.100706993 

    24/3236 AceView cDNA sequences (see all 3236):

    BM972321 AW131913 BQ943447 AW338386 BE928617 CB112013 BM449990 BQ951657 
    BU173655 AA354911 CB216613 BM694053 CA413824 BM475393 AI879185 AW002795 
    BX450263 BQ030314 AA052990 AI143064 AI375017 AA629770 BU552742 BM353653 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for H3F3B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:              -                 -                     
    SP2:                                -                     
    SP3:              -                 -                     
    SP4:              -                                       


    ECgene alternative splicing isoforms for H3F3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    H3F3B expression in normal human tissues (normalized intensities)      H3F3B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAACCCTCT
    H3F3B Expression
    About this image


    H3F3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See H3F3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for H3F3B

    SOURCE GeneReport for Unigene cluster: Hs.180877
        SABiosciences Custom PCR Arrays for H3F3B
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    OriGene qPCR primer pairs and template standards for H3F3B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H3F3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for H3F3B gene from 10/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H3f3b1 , 5 H3 histone, family 3B1, 5 91.91(n)1
    100(a)1
      11 (80.91 cM)5
    150811  NM_008211.31  NP_032237.11 
     1160219125 
    chicken
    (Gallus gallus)
    Aves H3F3C1 H3 histone, family 3C 79.9(n)
    99.26(a)
      427887  NM_001031482.1  NP_001026653.1 
    lizard
    (Anolis carolinensis)
    Reptilia H3F3B6
    H3 histone, family 3B (H3.3B)
    100(a)
    1 ↔ 1
    LGf(4206516-4214477)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC042290.12   -- 80.31(n)    BC042290.1 
    zebrafish
    (Danio rerio)
    Actinopterygii h3f3a1 H3 histone, family 3A 80.15(n)
    99.26(a)
      406269  NM_212996.1  NP_998161.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His3.3B3 chromatin assembly/disassembly DNA
    binding
    100(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea his-713
    his-741
    Histone H33
    Protein HIS-741
    99(a)
    (best of 4)3
    70.34(n)1
    93.38(a)1
      X(8016259-8017394)3
    1797341  NM_073763.31  NP_506164.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HHT26
    HHT16
    Histone H3, core histone protein required for chro...
    Histone H3, core histone protein required for chro...
    90(a)
    90(a)
    many ↔ many
    many ↔ many
    XIV(575640-576050)
    II(256331-256741)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G092001 histone H3 73.77(n)
    94.85(a)
      837440  NM_100790.2  NP_563838.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01595011 hypothetical protein 78.68(n)
    94.85(a)
      9269345  NM_001187682.1  NP_001174611.1 


    ENSEMBL Gene Tree for H3F3B (if available)
    TreeFam Gene Tree for H3F3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for H3F3B gene
    H3F3A1 2  HIST2H3D2  HIST1H3D2  HIST2H3C2  H3F3C2  HIST1H3H2  HIST1H3A2  HIST3H32  
    HIST1H3F2  HIST1H3G2  HIST1H3I2  HIST1H3B2  HIST1H3C2  HIST1H3J2  HIST1H3E2  HIST2H3A2  
    18 SIMAP similar genes for H3F3B using alignment to 6 protein entries:     H33_HUMAN (see all proteins):
    HIST1H3A    HIST1H3B    HIST1H3C    HIST1H3D    HIST1H3E    HIST1H3F
    HIST1H3G    HIST1H3H    HIST1H3I    HIST1H3J    HIST2H3A    HIST2H3C
    HIST2H3D    HIST3H3    HIST2H3PS2    H3F3C    H3F3A    CENPA

    H3F3B for paralogs           About GeneDecksing


    5/41 Pseudogenes.org Pseudogenes for H3F3B (see all 41)
    PGOHUM00000242171 PGOHUM00000239517 PGOHUM00000248627 PGOHUM00000247776 PGOHUM00000248109


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/182 SNPs in H3F3B are shown (see all 182)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397692551,2
    C--69197585(+) CTTTGA/GGAGGC 1 -- ds50010--------
    rs1443475851,2
    --69197596(+) CGAGGG/TGGGCA 1 -- ds50010--------
    rs124503491,2
    H--69197747(+) ggaacC/Ttgaga 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1850402911,2
    --69197753(+) TGAGAG/TGCGGG 1 -- ds50010--------
    rs1466094871,2
    C--69197757(+) AGGCGA/GGGGTT 1 -- ds50010--------
    rs1893616461,2
    --69197777(+) CAAGAG/TCGCGC 1 -- ds50010--------
    rs1117693511,2
    C,F--69197780(+) GATCGT/CGCCAC 1 -- ds50013Minor allele frequency- C:0.40WA CSA 5
    rs1923104531,2
    --69197833(+) AAATAA/CATACA 1 -- ds50010--------
    rs1421122161,2
    C--69197846(+) ACTTCA/TGCAGG 1 -- ds50010--------
    rs1847080921,2
    --69197850(+) CAGCAA/GGCACA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for H3F3B (73772515 - 73781974 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for H3F3B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908804CNV Loss21882294
    nsv470606CNV Loss18288195
    dgv3268n71CNV Loss21882294
    dgv3269n71CNV Loss21882294
    dgv3267n71CNV Loss21882294
    dgv3264n71CNV Loss21882294
    nsv833545CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601058    OMIM disorders: --

    3 diseases for H3F3B:    About MalaCards
    retinoblastoma    systemic lupus erythematosus    lupus erythematosus

    2 diseases from the University of Copenhagen DISEASES database for H3F3B:
    Leukemia     Retinoblastoma

    H3F3B for disorders           About GeneDecksing


    Export disorders for H3F3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for H3F3B gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with H3F3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human replacement histone H3.3B gene (H3F3B). (PubMed id 8586426)1, 2, 3, 9 Albig W.... Doenecke D. (1995)
    2. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    3. Histone H3 lysine 56 methylation regulates DNA replication through its interaction wwith PCNA. (PubMed id 22387026)2 Yu Y.... Grunstein M. (2012)
    4. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    5. Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. (PubMed id 22483618)2 Herranz N.... Peiro S. (2012)
    6. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (2011)
    9. ATRX interacts with H3.3 in maintaining telomere stru ctural integrity in pluripotent embryonic stem cells. (PubMed id 20110566)1 Wong L.H....Choo K.H. (2010)
    10. Phosphorylation of histone H3T6 by PKCbeta(I) control s demethylation at histone H3K4. (PubMed id 20228790)2 Metzger E....SchA1le R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3021 HGNC: 4765 AceView: H3F3B Ensembl:ENSG00000132475 euGenes: HUgn3021
    ECgene: H3F3B Kegg: 3021 H-InvDB: H3F3B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for H3F3B Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Histone_H3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for H3F3B gene:
    Search GeneIP for patents involving H3F3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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