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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

H3F3B Gene

protein-coding   GIFtS: 60
GCID: GC17M073749

H3 histone, family 3B (H3.3B)
 Explore 4 diseases affiliated with
H3F3B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for H3F3B    

Aliases
for H3F3B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
H3 Histone, Family 3B (H3.3B)1 2
H3.3B1 2 3
H3 Histone, Family 3A2
Histone H3.32
H3.3A3
H3F33

External Ids:    HGNC: 47651   Entrez Gene: 30212   Ensembl: ENSG000001324757   OMIM: 6010585   UniProtKB: P842433   

Export aliases for H3F3B gene to outside databases

Previous GC identifers: GC17M076798 GC17M074237 GC17M074371 GC17M074372 GC17M071284 GC17M069198


Summaries
for H3F3B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for H3F3B:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene
contains introns and its mRNA is poyadenylated, unlike most histone genes. The protein encoded is a member of the
histone H3 family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H33_HUMAN, P84243
Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes
the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA
synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents
an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting
DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in
transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a
complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling




Genomic Views
for H3F3B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the H3F3B gene promoter:
         Sox5   AML1a   Bach2   Arnt   Egr-4   Pax-3   HSF2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: H3F3B promoter sequence
   Search SABiosciences Chromatin IP Primers for H3F3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H3F3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

H3F3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H3F3B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M073749:  view genomic region     (about GC identifiers)

Start:
 73,772,515 bp from pter      End:
 73,781,974 bp from pter
Size:
 9,460 bases      Orientation:
 minus strand

Proteins
for H3F3B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H33_HUMAN, P84243 (See protein sequence)
Recommended Name: Histone H3.3  
Size: 136 amino acids; 15328 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA,
a chaperone required for its incorporation into nucleosomes
Subcellular location: Nucleus. Chromosome
Developmental stage: Expressed throughout the cell cycle independently of DNA synthesis
Sequence caution: Sequence=CAH73371.1; Type=Erroneous gene model prediction;
6/24 PDB 3D structures from and Proteopedia for H3F3B (see all 24):
2L43 (3D)        3ASK (3D)        3ASL (3D)        3AV2 (3D)        3JVK (3D)        3MUK (3D)    
Secondary accessions: P06351 P33155 Q5VV55 Q5VV56 Q66I33 Q9V3W4

Explore the universe of human proteins at neXtProt for H3F3B: NX_P84243

Post-translational modifications:

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    • (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me)1
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription1
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9
    • (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to
    gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the
    3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on
    active promoters1
  • Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37
    • and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80
    (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation
    at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at
    Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at
    Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary
    monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X
    chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and
    is required for DNA replication1
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation
    • at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and
    meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because
    it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV
    irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which
    is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from
    heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell
    transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon
    ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional
    activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at
    Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a
    specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.
    Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on
    Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes1
  • Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By
    • similarity)1
  • Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes
    • place on H3K4me3 and results in gene repression (PubMed:22483618)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P84243

    • H3F3B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005315.1  
    ENSEMBL proteins: 
     ENSP00000254810   ENSP00000467165   ENSP00000466663   ENSP00000468714   ENSP00000465813  
     ENSP00000466020   ENSP00000465403   ENSP00000468484  
    Reactome Protein details: P84243
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: H3F3B
    OriGene Custom Protein Services for H3F3B 
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    Novus Biologicals H3F3B Proteins
    Novus Biologicals H3F3B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for H3F3B

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005576extracellular region TAS--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--


    H3F3B for ontologies           About GeneDecksing



    H3F3B Antibody Products: 
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    Abcam antibodies for H3F3B 
    Uscn Antibodies for H3F3B
    ThermoFisher Antibody for H3F3B

    Assay Products for H3F3B: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for H3F3B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for H3F3B

    Protein Domains /
    Families
    for H3F3B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    H3F3B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P84243

    ProtoNet protein and cluster: P84243

    UniProtKB/Swiss-Prot: H33_HUMAN, P84243
    Similarity: Belongs to the histone H3 family


    Function
    for H3F3B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H33_HUMAN, P84243
    Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes
    the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA
    synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents
    an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting
    DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in
    transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a
    complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

         Genatlas biochemistry entry for H3F3B:
    histone family 3,replacement subtype,replication independent protein,species H3.3B

    miRNA
    Products:            		miRTarBase miRNAs that target H3F3B:
    hsa-mir-1 (MIRT002794)

    OriGene 3'-UTR Clone: H3F3B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H3F3B
    8/124 QIAGEN miScript miRNA Assays for microRNAs that regulate H3F3B (see all 124):
    hsa-miR-188-5p hsa-miR-938 hsa-miR-605 hsa-miR-128 hsa-miR-374a hsa-miR-890 hsa-miR-208b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: H3F3B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for H3F3B (see all 7)
    OriGene shRNA RFP: H3F3B
    OriGene siRNA: H3F3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H3F3B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for H3F3B

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H3F3B (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for H3F3B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H3F3B

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--


    H3F3B for ontologies           About GeneDecksing



    Pathways & Interactions
    for H3F3B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    2Transcription_Sin3 and NuRD in transcription regulation
    		Transcription_Sin3 and NuRD in transcription regulation1.00
    		Transcription Sin3 and NuRD in transcription regulation0.96
    3Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97
    4Cell cycle Chromosome condensation in prometaphase
    		Cell cycle Chromosome condensation in prometaphase1.00
    		Cell cycle_Chromosome condensation in prometaphase1.00
    5Development NOTCH1-mediated pathway for NF-KB activity modulation
    		Development NOTCH1-mediated pathway for NF-KB activity modulation1.00
    		Development_NOTCH1-mediated pathway for NF-KB activity modulation0.88

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for H3F3B (see all 6)
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Cell cycle Chromosome condensation in prometaphase

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for H3F3B (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    PKA Signaling
    UVB-Induced MAPK Signaling
    Interferon Pathway
    Crosstalk Between CARM1 and ESRs

    5 GeneGo (Thomson Reuters) Pathways for H3F3B
        Cell cycle Chromosome condensation in prometaphase
    Signal transduction Activin A signaling regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Development Notch Signaling Pathway

    5/6        Reactome Pathways for H3F3B (see all 6)
        Amyloids
    Hemostasis
    Factors involved in megakaryocyte development and platelet production
    Meiosis
    Meiotic Recombination


    1         Kegg Pathway  (Kegg details for H3F3B):
        Systemic lupus erythematosus


    H3F3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H3F3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/294 Interacting proteins for H3F3B (P842432, 3 ENSP000002548104) via UniProtKB, MINT, STRING, and/or I2D (see all 294)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PELP1Q8IZL82, 3MINT-7903569 MINT-7903490 MINT-7903524 MINT-7903607 MINT-7903554 MINT-7903511 MINT-7903461 MINT-7903594 MINT-7903394 MINT-7903444 MINT-7903429 I2D: score=1 
    HIST1H4BP628053, ENSP000003665814I2D: score=23 STRING: ENSP00000366581
    HIST1H4AP628053I2D: score=23 
    HIST1H4CP628053I2D: score=23 
    HIST1H4DP628053I2D: score=23 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0007420brain development ----
    GO:0007596blood coagulation TAS--
    GO:0009725response to hormone stimulus ----


    H3F3B for ontologies           About GeneDecksing



    Drugs & Compounds
    for H3F3B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for H3F3B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for H3F3B
    Search CenterWatch for drugs/clinical trials and news about H3F3B / H33 

    Transcripts
    for H3F3B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for H3F3B gene: 
    NM_005324.3  

    Unigene Cluster for H3F3B:

    H3 histone, family 3B (H3.3B)
    Hs.180877  [show with all ESTs]
    Unigene Representative Sequence: BX537379
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254810(uc002jpl.3) ENST00000593254 ENST00000586518 ENST00000592643
    ENST00000591890 ENST00000589949 ENST00000587560 ENST00000589599 ENST00000586607
    ENST00000586270 ENST00000587171 ENST00000589417 ENST00000591893

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H3F3B
    8/124 QIAGEN miScript miRNA Assays for microRNAs that regulate H3F3B (see all 124):
    hsa-miR-188-5p hsa-miR-938 hsa-miR-605 hsa-miR-128 hsa-miR-374a hsa-miR-890 hsa-miR-208b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: H3F3B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for H3F3B (see all 7)
    OriGene shRNA RFP: H3F3B
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H3F3B
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H3F3B
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    Additional cDNA sequence: 

    AF218029.1 AK054591.1 AK130772.1 AK304607.1 AK312762.1 BC001124.2 BC006497.2 BC012813.2 
    BC017558.1 BC020466.1 BC108701.1 BX537379.1 BX647280.1 

    24/86 DOTS entries (see all 86):

    DT.91778033  DT.100706978  DT.91778014  DT.91778022  DT.91778028  DT.100706984  DT.100837098  DT.100707000 
    DT.120913319  DT.92325522  DT.100706983  DT.120913311  DT.120913435  DT.102839701  DT.100706990  DT.100706989 
    DT.87017903  DT.91986813  DT.100706982  DT.100058702  DT.100707002  DT.120913371  DT.40115786  DT.100706993 

    24/3236 AceView cDNA sequences (see all 3236):

    BM757976 BQ030314 AI625546 BQ653584 AL709675 BM914900 CR605171 AA953317 
    CA309050 BM758365 AA971497 AA608967 BU147153 CR606388 BU541080 CB070121 
    BU163598 BQ684383 BQ286211 W74604 W58216 BU628398 BU072431 AA468606 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for H3F3B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:              -                 -                     
    SP2:                                -                     
    SP3:              -                 -                     
    SP4:              -                                       


    ECgene alternative splicing isoforms for H3F3B

    Expression
    for H3F3B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    H3F3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAACCCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    H3F3B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive ErythrocytesBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See H3F3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for H3F3B

    SOURCE GeneReport for Unigene cluster: Hs.180877
        SABiosciences Custom PCR Arrays for H3F3B
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for H3F3B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for H3F3B gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves H3F3C1 H3 histone, family 3C 79.9(n)
    99.26(a)    		   427887  NM_001031482.1  NP_001026653.1 
    lizard
    (Anolis carolinensis)    		 Reptilia H3F3C6
    H3F3B6
    		 --
    		 100(a)
    100(a)
    		 possible ortholog
    possible ortholog
    		 LGf(4207521-4211357)
    1(251561435-251568824)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC042290.12   -- 80.31(n)    BC042290.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii h3f3a1 H3 histone, family 3A 80.15(n)
    99.26(a)    		   406269  NM_212996.1  NP_998161.1 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0121961 AGAP012196-PA 81.62(n)
    98.53(a)    		   1280490  XM_320336.2  XP_320336.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea his-713
    his-741    		 Histone H33
    Protein HIS-741    		 99(a)
    (best of 4)3
    70.34(n)1
    93.38(a)1    		   X(8016259-8017394)3
    1797341  NM_073763.31  NP_506164.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G092001 histone H3 73.77(n)
    94.85(a)    		   837440  NM_100790.2  NP_563838.1 
    rice
    (Oryza sativa)    		 Liliopsida Os06g01595011 hypothetical protein 78.68(n)
    94.85(a)    		   9269345  NM_001187682.1  NP_001174611.1 


    ENSEMBL Gene Tree for H3F3B (if available)
    TreeFam Gene Tree for H3F3B (if available) 

    Paralogs
    for H3F3B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for H3F3B gene
    H3F3A1 2  HIST2H3C2  H3F3C2  HIST1H3A2  HIST1H3B2  HIST1H3J2  HIST1H3E2  HIST2H3D2  
    HIST1H3D2  HIST1H3H2  HIST3H32  HIST1H3F2  HIST1H3G2  HIST1H3I2  HIST1H3C2  HIST2H3A2  
    18 SIMAP similar genes for H3F3B using alignment to 5 protein entries:     H33_HUMAN (see all proteins):
    HIST1H3A    HIST1H3B    HIST1H3C    HIST1H3D    HIST1H3E    HIST1H3F
    HIST1H3G    HIST1H3H    HIST1H3I    HIST1H3J    HIST2H3A    HIST2H3C
    HIST2H3D    HIST3H3    HIST2H3PS2    H3F3A    H3F3C    CENPA

    H3F3B for paralogs           About GeneDecksing


    5/41 Pseudogenes.org Pseudogenes for H3F3B (see all 41)
    PGOHUM00000242171 PGOHUM00000239517 PGOHUM00000248627 PGOHUM00000247776 PGOHUM00000248109


    Genomic Variants
    for H3F3B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H3F3B
    DNA2.0 Custom Variant and Variant Library Synthesis for H3F3B

    Disorders / Diseases
    for H3F3B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    H3F3B for disorders           About GeneDecksing

    OMIM gene information: 601058    OMIM disorders: --

    4 diseases for H3F3B:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    immunodeficiency    malaria

    2 diseases from the University of Copenhagen DISEASES database for H3F3B:
    Leukemia     Retinoblastoma

    Export disorders for H3F3B gene to outside databases

    Publications
    for H3F3B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for H3F3B gene, integrated from 9 sources (see all 75):
    (articles sorted by number of sources associating them with H3F3B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human replacement histone H3.3B gene (H3F3B). (PubMed id 8586426)1, 2, 3, 9 Albig W.... Doenecke D. (1995)
    2. Histone H3 lysine 56 methylation regulates DNA replication through its interaction wwith PCNA. (PubMed id 22387026)2 Yu Y.... Grunstein M. (2012)
    3. Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. (PubMed id 22483618)2 Herranz N.... Peiro S. (2012)
    4. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (2011)
    7. ATRX interacts with H3.3 in maintaining telomere stru ctural integrity in pluripotent embryonic stem cells. (PubMed id 20110566)1 Wong L.H....Choo K.H. (2010)
    8. Phosphorylation of histone H3T6 by PKCbeta(I) control s demethylation at histone H3K4. (PubMed id 20228790)2 Metzger E....SchA1le R. (2010)
    9. The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. (PubMed id 20504901)1 DranAc P....Hamiche A. (2010)
    10. Quantitative interaction proteomics and genome-wide p rofiling of epigenetic histone marks and their readers. (PubMed id 20850016)2 Vermeulen M....Mann M. (2010)

    External Searches for H3F3B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing H3F3B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3021 HGNC: 4765 AceView: H3F3B Ensembl:ENSG00000132475 euGenes: HUgn3021
    ECgene: H3F3B Kegg: 3021 H-InvDB: H3F3B

    Other Databases showing H3F3B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing H3F3B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for H3F3B Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Histone_H3

    Intellectual Property
    for H3F3B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for H3F3B gene:
    Search GeneIP for patents involving H3F3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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