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Aliases &
Descriptions
for H2BFWT
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| MGC148130 2 | | MGC148131 2 |
| | | Descriptions |
|---|
| H2B histone family member W testis-specific 3 | | H2B histone family, member W, testis-specific 2 |
|
| |
Search outside databases for aliases for H2BFWT genePrevious GC identifers: GC0XM102038 GC0XM103071 |
Summaries
for H2BFWT(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for H2BFWT:
Testis-specific histones, like H2BFWT, are synthesized and accumulate at specific stages of
mammalian spermatogenesis. Their proposed functions range from facilitation of the replacement of
somatic histones by protamines to epigenetic control of gene transcription (Churikov et al., 2004
[PubMed 15475252]).[supplied by OMIM]
UniProtKB/Swiss-Prot: H2BWT_HUMAN, Q7Z2G1Function: Atypical histone H2B. Nucleosomes containing it are structurally and dynamically
indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does
not recruit chromosome condensation factors and does not participate in the assembly of mitotic
chromosomes. May be important for telomere function |
Genomic Location
for H2BFWT
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the H2BFWT gene 
Entrez Gene cytogenetic band: Xq22.2 Ensembl cytogenetic band: Xq22.2 HGNC cytogenetic band: Xq22.2H2BFWT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM103153:
(about GC identifiers)
Start:
|
103,152,376 bp from pter |
End:
|
103,196,495 bp from pter |
Size:
|
44,120 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011651.16
| Proteins
for H2BFWT
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: H2BWT_HUMAN, Q7Z2G1 (See
protein sequence)Recommended Name: Histone H2B type W-T Size: 175 amino acids; 19618 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4
assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps
approximately 147 bp of DNA
Subcellular location: Nucleus membrane
Miscellaneous: In contrast to other H2B histones, it does not contain the conserved residue in
C-terminus that is the target of monoubiquitination
Miscellaneous: Ortholog in primates, but not in rodents
Secondary accessions: B1AK72 Q147W3REFSEQ proteins: NP_001002916.1
ENSEMBL proteins: ENSP00000354723 ENSP00000361683
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for H2BFWT:
Assays for H2BFWT: | Protein
Domains/
Families
for H2BFWT(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q7Z2G1
ProtoNet protein and cluster: Q7Z2G1 UniProtKB/Swiss-Prot: H2BWT_HUMAN, Q7Z2G1Similarity: Belongs to the histone H2B family | Gene Function
for H2BFWT
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001002916
 Applied Biosystems Silencer® siRNAs for H2BFWT
 Sigma-Aldrich siRNA for H2BFWT
Sigma-Aldrich shRNA for H2BFWT
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_001002916
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001002916
untagged cDNA clone in CMV expression vector: NM_001002916
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_001002916
UniProtKB/Swiss-Prot: H2BWT_HUMAN, Q7Z2G1Function: Atypical histone H2B. Nucleosomes containing it are structurally and dynamically
indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does
not recruit chromosome condensation factors and does not participate in the assembly of mitotic
chromosomes. May be important for telomere function1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
About this table | Pathways & Interactions
for H2BFWT
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
IEA | -- |
About this table
|
Drugs & Compounds
for H2BFWT(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for H2BFWT
|
Transcripts
for H2BFWT(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001002916
Sigma-Aldrich siRNA for H2BFWT
Sigma-Aldrich shRNA for H2BFWT
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_001002916 REFSEQ mRNAs for H2BFWT gene: NM_001002916.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001002916
OriGene GFP tagged cDNA clone in CMV expression vector: NM_001002916
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001002916
untagged cDNA clone in CMV expression vector: NM_001002916
Additional cDNA sequence: AY283370.1 BC038109.2 BC118604.1 BC121816.1 1 DOTS entry: DT.40127079 7 AceView cDNA sequences:AI143866 AA961176 NM_001002916 BC038109 AY283370 BI459475 BX095740
 highest scoring ESTs for H2BFWT:AA961176 AY283370 BC038109 BI459475 AI143866 BX095740 BC118604 BC121816 NM_001002916 XM_088735 Unigene Cluster for H2BFWT: H2B histone family, member W, testis-specific Hs.127778 [show with all ESTs]Unigene Representative Sequence: NM_001002916
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000217926
ENST00000372601
|
Expression
for H2BFWT
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| H2BFWT expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for H2BFWT
1 / 2 / 3 1 probe-set matching H2BFWT gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACATATTGGA
SOURCE GeneReport for Unigene cluster: Hs.127778
UniProtKB/Swiss-Prot: H2BWT_HUMAN, Q7Z2G1Tissue specificity: Testis-specific. Present in sperm cells (at protein level) |
Orthologs
for H2BFWT
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for H2BFWT gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
LOC4737121 |
-- |
similar to histone H2B-related protein |
97.67(n)
95.35(a) |
473712 XM_529085.2 XP_529085.2 |
About this table Species with no ortholog for H2BFWT
ENSEMBL Gene Tree for H2BFWT | Paralogs
for H2BFWT(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for H2BFWT gene
- H2BFM2
|
SNPs/Variants
for H2BFWT(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
The following additional 20 SNP(s) have been
found in Applied Biosystems data source:
(Click
for
Applied Biosystems TaqMan ® Genotyping Assay)
HapMap Linkage Disequilibrium images for H2BFWT (up to first 250kb)
|
Disorders & Mutations
for H2BFWT
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300507
|
Medical News
for H2BFWT(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for H2BFWT (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 6 PubMed articles for H2BFWT gene: |
Search for H2BFWT
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing H2BFWT
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing H2BFWT
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H2BFWT(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for H2BFWT(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for H2BFWT:
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| | |  | Search Tocris compounds for H2BFWT |
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