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Aliases for H2BFWT Gene

Aliases for H2BFWT Gene

  • H2B Histone Family Member W, Testis Specific 2 3 5
  • H2B Histone Family, Member W, Testis-Specific 2
  • H2B Histone Family Member W Testis-Specific 4

External Ids for H2BFWT Gene

Previous GeneCards Identifiers for H2BFWT Gene

  • GC0XM102038
  • GC0XM103071
  • GC0XM103153
  • GC0XM103265
  • GC0XM092921

Summaries for H2BFWT Gene

Entrez Gene Summary for H2BFWT Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[provided by RefSeq, Oct 2015]

GeneCards Summary for H2BFWT Gene

H2BFWT (H2B Histone Family Member W, Testis Specific) is a Protein Coding gene. Diseases associated with H2BFWT include Male Infertility. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Viral carcinogenesis. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is H2BFM.

UniProtKB/Swiss-Prot for H2BFWT Gene

  • Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H2BFWT Gene

Genomics for H2BFWT Gene

Regulatory Elements for H2BFWT Gene


Genomic Location for H2BFWT Gene

Chromosome:
X
Start:
104,011,147 bp from pter
End:
104,013,687 bp from pter
Size:
2,541 bases
Orientation:
Minus strand

Genomic View for H2BFWT Gene

Genes around H2BFWT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2BFWT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2BFWT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BFWT Gene

Proteins for H2BFWT Gene

  • Protein details for H2BFWT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2G1-H2BWT_HUMAN
    Recommended name:
    Histone H2B type W-T
    Protein Accession:
    Q7Z2G1
    Secondary Accessions:
    • B1AK72
    • Q147W3

    Protein attributes for H2BFWT Gene

    Size:
    175 amino acids
    Molecular mass:
    19618 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    Miscellaneous:
    • In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is the target of monoubiquitination.
    • Ortholog in primates, but not in rodents.

neXtProt entry for H2BFWT Gene

Post-translational modifications for H2BFWT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for H2BFWT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H2BFWT Gene

Domains & Families for H2BFWT Gene

Gene Families for H2BFWT Gene

Protein Domains for H2BFWT Gene

Suggested Antigen Peptide Sequences for H2BFWT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z2G1

UniProtKB/Swiss-Prot:

H2BWT_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BFWT: view

Function for H2BFWT Gene

Molecular function for H2BFWT Gene

UniProtKB/Swiss-Prot Function:
Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.

Gene Ontology (GO) - Molecular Function for H2BFWT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H2BFWT: view

Phenotypes for H2BFWT Gene

GenomeRNAi human phenotypes for H2BFWT:
genes like me logo Genes that share phenotypes with H2BFWT: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H2BFWT Gene

Localization for H2BFWT Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BFWT Gene

Nucleus membrane. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H2BFWT gene
Compartment Confidence
nucleus 4
mitochondrion 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for H2BFWT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0016020 membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with H2BFWT: view

Pathways & Interactions for H2BFWT Gene

genes like me logo Genes that share pathways with H2BFWT: view

Pathways by source for H2BFWT Gene

Gene Ontology (GO) - Biological Process for H2BFWT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IBA --
genes like me logo Genes that share ontologies with H2BFWT: view

No data available for SIGNOR curated interactions for H2BFWT Gene

Transcripts for H2BFWT Gene

mRNA/cDNA for H2BFWT Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for H2BFWT Gene

H2B histone family, member W, testis-specific:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for H2BFWT Gene

No ASD Table

Relevant External Links for H2BFWT Gene

GeneLoc Exon Structure for
H2BFWT
ECgene alternative splicing isoforms for
H2BFWT

Expression for H2BFWT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for H2BFWT Gene

mRNA differential expression in normal tissues according to GTEx for H2BFWT Gene

This gene is overexpressed in Testis (x40.7).

Protein differential expression in normal tissues from HIPED for H2BFWT Gene

This gene is overexpressed in Nasal epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for H2BFWT Gene



Protein tissue co-expression partners for H2BFWT Gene

NURSA nuclear receptor signaling pathways regulating expression of H2BFWT Gene:

H2BFWT

SOURCE GeneReport for Unigene cluster for H2BFWT Gene:

Hs.127778

mRNA Expression by UniProt/SwissProt for H2BFWT Gene:

Q7Z2G1-H2BWT_HUMAN
Tissue specificity: Testis-specific. Present in sperm cells (at protein level).
genes like me logo Genes that share expression patterns with H2BFWT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H2BFWT Gene

Orthologs for H2BFWT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for H2BFWT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H2BFWT 35
  • 97 (a)
OneToOne
LOC473712 34
  • 96.38 (n)
dog
(Canis familiaris)
Mammalia H2BFWT 34
  • 68.78 (n)
-- 35
  • 55 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LOC523458 34
  • 67.59 (n)
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 29 (a)
OneToMany
mouse
(Mus musculus)
Mammalia H2bfm 35
  • 25 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-190p8.2 35
  • 45 (a)
ManyToMany
zgc:92591 35
  • 45 (a)
ManyToMany
si:dkey-108k21.11 35
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta His2B:CG17949 35
  • 44 (a)
ManyToMany
His2B:CG33868 35
  • 44 (a)
ManyToMany
His2B:CG33870 35
  • 44 (a)
ManyToMany
His2B:CG33872 35
  • 44 (a)
ManyToMany
His2B:CG33874 35
  • 44 (a)
ManyToMany
His2B:CG33876 35
  • 44 (a)
ManyToMany
His2B:CG33878 35
  • 44 (a)
ManyToMany
His2B:CG33880 35
  • 44 (a)
ManyToMany
His2B:CG33882 35
  • 44 (a)
ManyToMany
His2B:CG33884 35
  • 44 (a)
ManyToMany
His2B:CG33886 35
  • 44 (a)
ManyToMany
His2B:CG33888 35
  • 44 (a)
ManyToMany
His2B:CG33890 35
  • 44 (a)
ManyToMany
His2B:CG33892 35
  • 44 (a)
ManyToMany
His2B:CG33894 35
  • 44 (a)
ManyToMany
His2B:CG33896 35
  • 44 (a)
ManyToMany
His2B:CG33898 35
  • 44 (a)
ManyToMany
His2B:CG33902 35
  • 44 (a)
ManyToMany
His2B:CG33904 35
  • 44 (a)
ManyToMany
His2B:CG33906 35
  • 44 (a)
ManyToMany
His2B:CG33908 35
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea his-39 35
  • 44 (a)
ManyToMany
his-11 35
  • 43 (a)
ManyToMany
his-15 35
  • 43 (a)
ManyToMany
his-29 35
  • 43 (a)
ManyToMany
his-34 35
  • 43 (a)
ManyToMany
his-44 35
  • 43 (a)
ManyToMany
his-48 35
  • 42 (a)
ManyToMany
his-58 35
  • 42 (a)
ManyToMany
his-62 35
  • 42 (a)
ManyToMany
his-66 35
  • 42 (a)
ManyToMany
his-20 35
  • 41 (a)
ManyToMany
his-22 35
  • 41 (a)
ManyToMany
his-4 35
  • 41 (a)
ManyToMany
his-41 35
  • 41 (a)
ManyToMany
his-52 35
  • 41 (a)
ManyToMany
his-8 35
  • 41 (a)
ManyToMany
his-54 35
  • 37 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HTB1 35
  • 34 (a)
ManyToMany
HTB2 35
  • 34 (a)
ManyToMany
Species where no ortholog for H2BFWT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for H2BFWT Gene

ENSEMBL:
Gene Tree for H2BFWT (if available)
TreeFam:
Gene Tree for H2BFWT (if available)

Paralogs for H2BFWT Gene

Paralogs for H2BFWT Gene

Pseudogenes.org Pseudogenes for H2BFWT Gene

genes like me logo Genes that share paralogs with H2BFWT: view

Variants for H2BFWT Gene

Sequence variations from dbSNP and Humsavar for H2BFWT Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000081745 -- 104,014,665(+) ATTCT(A/G)CTCCT upstream-variant-2KB
rs1003947912 -- 104,015,626(+) GTGCC(A/G)ATTAT upstream-variant-2KB
rs1003980744 -- 104,015,348(+) CACCC(A/G)GCTAA upstream-variant-2KB
rs1014156760 -- 104,014,201(+) ATGGC(A/C)ATACC upstream-variant-2KB
rs1015277200 -- 104,014,907(+) TCAGC(A/G)TGATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for H2BFWT Gene

Variant ID Type Subtype PubMed ID
dgv2356e212 CNV gain 25503493
dgv5n1 OTHER inversion 15895083
dgv63n47 OTHER inversion 21111241
esv1007027 OTHER inversion 20482838
esv22275 CNV gain 19812545
esv2758880 CNV gain 17122850
esv32549 CNV loss 17666407
esv3577013 CNV gain 25503493
esv3577033 CNV gain 25503493
nsv1129090 CNV duplication 24896259
nsv208 OTHER inversion 15895083
nsv469772 CNV gain 16826518
nsv519626 CNV gain 19592680
nsv7453 OTHER inversion 18451855

Variation tolerance for H2BFWT Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for H2BFWT Gene

Human Gene Mutation Database (HGMD)
H2BFWT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
H2BFWT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2BFWT Gene

Disorders for H2BFWT Gene

MalaCards: The human disease database

(1) MalaCards diseases for H2BFWT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for H2BFWT

Genetic Association Database (GAD)
H2BFWT
Human Genome Epidemiology (HuGE) Navigator
H2BFWT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
H2BFWT
genes like me logo Genes that share disorders with H2BFWT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for H2BFWT Gene

Publications for H2BFWT Gene

  1. Novel human testis-specific histone H2B encoded by the interrupted gene on the X chromosome. (PMID: 15475252) Churikov D. … Zalensky A. (Genomics 2004) 2 3 4 64
  2. Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertility. (PMID: 19583817) Lee J. … Lee S. (J. Cell. Mol. Med. 2009) 3 46 64
  3. The NH2 tail of the novel histone variant H2BFWT exhibits properties distinct from conventional H2B with respect to the assembly of mitotic chromosomes. (PMID: 16449661) Boulard M. … Dimitrov S. (Mol. Cell. Biol. 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for H2BFWT Gene

Sources for H2BFWT Gene

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