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Aliases for H2BFWT Gene

Aliases for H2BFWT Gene

  • H2B Histone Family, Member W, Testis-Specific 2 3
  • H2B Histone Family Member W Testis-Specific 4

External Ids for H2BFWT Gene

Previous GeneCards Identifiers for H2BFWT Gene

  • GC0XM102038
  • GC0XM103071
  • GC0XM103153
  • GC0XM103265
  • GC0XM092921

Summaries for H2BFWT Gene

Entrez Gene Summary for H2BFWT Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[provided by RefSeq, Jan 2010]

GeneCards Summary for H2BFWT Gene

H2BFWT (H2B Histone Family, Member W, Testis-Specific) is a Protein Coding gene. Diseases associated with H2BFWT include male infertility and infertility. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2BA.

UniProtKB/Swiss-Prot for H2BFWT Gene

  • Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H2BFWT Gene

Genomics for H2BFWT Gene

Regulatory Elements for H2BFWT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for H2BFWT Gene

Start:
104,011,147 bp from pter
End:
104,013,687 bp from pter
Size:
2,541 bases
Orientation:
Minus strand

Genomic View for H2BFWT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for H2BFWT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BFWT Gene

Proteins for H2BFWT Gene

  • Protein details for H2BFWT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2G1-H2BWT_HUMAN
    Recommended name:
    Histone H2B type W-T
    Protein Accession:
    Q7Z2G1
    Secondary Accessions:
    • B1AK72
    • Q147W3

    Protein attributes for H2BFWT Gene

    Size:
    175 amino acids
    Molecular mass:
    19618 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
    Miscellaneous:
    • In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is the target of monoubiquitination
    • Ortholog in primates, but not in rodents

neXtProt entry for H2BFWT Gene

Proteomics data for H2BFWT Gene at MOPED

Post-translational modifications for H2BFWT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for H2BFWT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H2BFWT Gene

Domains for H2BFWT Gene

Gene Families for H2BFWT Gene

HGNC:
  • RIH :Histones / Replication-independent

Protein Domains for H2BFWT Gene

Suggested Antigen Peptide Sequences for H2BFWT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z2G1

UniProtKB/Swiss-Prot:

H2BWT_HUMAN :
  • Q7Z2G1
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BFWT: view

Function for H2BFWT Gene

Molecular function for H2BFWT Gene

UniProtKB/Swiss-Prot Function:
Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.

Gene Ontology (GO) - Molecular Function for H2BFWT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H2BFWT: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H2BFWT

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for H2BFWT Gene

Localization for H2BFWT Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BFWT Gene

Nucleus membrane. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for H2BFWT Gene COMPARTMENTS Subcellular localization image for H2BFWT gene
Compartment Confidence
nucleus 5
mitochondrion 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for H2BFWT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome --
GO:0000788 nuclear nucleosome IBA --
GO:0005634 nucleus --
GO:0016020 membrane --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with H2BFWT: view

Pathways for H2BFWT Gene

genes like me logo Genes that share pathways with H2BFWT: view

Pathways by source for H2BFWT Gene

Gene Ontology (GO) - Biological Process for H2BFWT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IBA --
genes like me logo Genes that share ontologies with H2BFWT: view

Transcripts for H2BFWT Gene

mRNA/cDNA for H2BFWT Gene

(1) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for H2BFWT Gene

H2B histone family, member W, testis-specific:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H2BFWT

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for H2BFWT Gene

No ASD Table

Relevant External Links for H2BFWT Gene

GeneLoc Exon Structure for
H2BFWT
ECgene alternative splicing isoforms for
H2BFWT

Expression for H2BFWT Gene

mRNA expression in normal human tissues for H2BFWT Gene

mRNA differential expression in normal tissues according to GTEx for H2BFWT Gene

This gene is overexpressed in Testis (40.7).

Protein differential expression in normal tissues for H2BFWT Gene

This gene is overexpressed in Nasal epithelium (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for H2BFWT Gene

SOURCE GeneReport for Unigene cluster for H2BFWT Gene Hs.127778

mRNA Expression by UniProt/SwissProt for H2BFWT Gene

Q7Z2G1-H2BWT_HUMAN
Tissue specificity: Testis-specific. Present in sperm cells (at protein level).
genes like me logo Genes that share expressions with H2BFWT: view

Expression partners for H2BFWT Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for H2BFWT Gene

Orthologs for H2BFWT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for H2BFWT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC523458 35
  • 67.59 (n)
  • 57.41 (a)
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia H2BFWT 35
  • 68.78 (n)
  • 57.04 (a)
-- 36
  • 55 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC473712 35
  • 96.38 (n)
  • 94.86 (a)
H2BFWT 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H2bfm 36
  • 25 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-190p8.2 36
  • 45 (a)
ManyToMany
si:dkey-108k21.11 36
  • 41 (a)
ManyToMany
zgc:92591 36
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta His2B:CG17949 36
  • 44 (a)
ManyToMany
His2B:CG33868 36
  • 44 (a)
ManyToMany
His2B:CG33870 36
  • 44 (a)
ManyToMany
His2B:CG33872 36
  • 44 (a)
ManyToMany
His2B:CG33874 36
  • 44 (a)
ManyToMany
His2B:CG33876 36
  • 44 (a)
ManyToMany
His2B:CG33878 36
  • 44 (a)
ManyToMany
His2B:CG33880 36
  • 44 (a)
ManyToMany
His2B:CG33882 36
  • 44 (a)
ManyToMany
His2B:CG33884 36
  • 44 (a)
ManyToMany
His2B:CG33886 36
  • 44 (a)
ManyToMany
His2B:CG33888 36
  • 44 (a)
ManyToMany
His2B:CG33890 36
  • 44 (a)
ManyToMany
His2B:CG33892 36
  • 44 (a)
ManyToMany
His2B:CG33894 36
  • 44 (a)
ManyToMany
His2B:CG33896 36
  • 44 (a)
ManyToMany
His2B:CG33898 36
  • 44 (a)
ManyToMany
His2B:CG33902 36
  • 44 (a)
ManyToMany
His2B:CG33904 36
  • 44 (a)
ManyToMany
His2B:CG33906 36
  • 44 (a)
ManyToMany
His2B:CG33908 36
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea his-11 36
  • 43 (a)
ManyToMany
his-15 36
  • 43 (a)
ManyToMany
his-20 36
  • 41 (a)
ManyToMany
his-22 36
  • 41 (a)
ManyToMany
his-29 36
  • 43 (a)
ManyToMany
his-34 36
  • 43 (a)
ManyToMany
his-39 36
  • 44 (a)
ManyToMany
his-4 36
  • 41 (a)
ManyToMany
his-41 36
  • 41 (a)
ManyToMany
his-44 36
  • 43 (a)
ManyToMany
his-48 36
  • 42 (a)
ManyToMany
his-52 36
  • 41 (a)
ManyToMany
his-54 36
  • 37 (a)
ManyToMany
his-58 36
  • 42 (a)
ManyToMany
his-62 36
  • 42 (a)
ManyToMany
his-66 36
  • 42 (a)
ManyToMany
his-8 36
  • 41 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HTB1 36
  • 34 (a)
ManyToMany
HTB2 36
  • 34 (a)
ManyToMany
Species with no ortholog for H2BFWT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for H2BFWT Gene

ENSEMBL:
Gene Tree for H2BFWT (if available)
TreeFam:
Gene Tree for H2BFWT (if available)

Paralogs for H2BFWT Gene

Paralogs for H2BFWT Gene

Pseudogenes.org Pseudogenes for H2BFWT Gene

genes like me logo Genes that share paralogs with H2BFWT: view

Variants for H2BFWT Gene

Sequence variations from dbSNP and Humsavar for H2BFWT Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs553509 - 104,013,293(+) CCAGG(C/T)GACCA reference, missense
rs578953 -- 104,013,761(+) GTCCC(A/G)TTGCG upstream-variant-2KB
rs6523765 -- 104,012,580(+) ATGAA(C/T)GGATT intron-variant
rs7885967 -- 104,013,669(+) TCCAC(A/G)TCTCG utr-variant-5-prime
rs13440779 -- 104,011,352(+) CCTGG(A/C)GGCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for H2BFWT Gene

Variant ID Type Subtype PubMed ID
dgv2459e1 CNV Complex 17122850
nsv469772 CNV Complex 16826518
nsv519626 CNV Gain 19592680
nsv7453 OTHER Inversion 18451855
esv1007027 OTHER Inversion 20482838
nsv208 OTHER Inversion 15895083
dgv63n47 OTHER Inversion 21111241
dgv2460e1 CNV Complex 17122850
dgv5n1 OTHER Inversion 15895083
esv22275 CNV Gain 19812545
esv32549 CNV Loss 17666407

Relevant External Links for H2BFWT Gene

HapMap Linkage Disequilibrium report
H2BFWT
Human Gene Mutation Database (HGMD)
H2BFWT
Locus Specific Mutation Databases (LSDB)
H2BFWT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2BFWT Gene

Disorders for H2BFWT Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for H2BFWT Gene in MalaCards »

(2) Diseases for H2BFWT Gene including...

(1) University of Copenhagen DISEASES for H2BFWT Gene

Relevant External Links for H2BFWT

Genetic Association Database (GAD)
H2BFWT
Human Genome Epidemiology (HuGE) Navigator
H2BFWT
genes like me logo Genes that share disorders with H2BFWT: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for H2BFWT Gene

Publications for H2BFWT Gene

  1. Novel human testis-specific histone H2B encoded by the interrupted gene on the X chromosome. (PMID: 15475252) Churikov D. … Zalensky A. (Genomics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The NH2 tail of the novel histone variant H2BFWT exhibits properties distinct from conventional H2B with respect to the assembly of mitotic chromosomes. (PMID: 16449661) Boulard M. … Dimitrov S. (Mol. Cell. Biol. 2006) 3 4
  4. Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertility. (PMID: 19583817) Lee J. … Lee S. (J. Cell. Mol. Med. 2009) 3 48
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3

Products for H2BFWT Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate H2BFWT
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for H2BFWT
    • Block miRNA regulation of H2BFWT using miScript Target Protectors

    Sources for H2BFWT Gene

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