Aliases for H2BFWT Gene
External Ids for H2BFWT Gene
Previous GeneCards Identifiers for H2BFWT Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[provided by RefSeq, Oct 2015]
GeneCards Summary for H2BFWT Gene
H2BFWT (H2B Histone Family Member W, Testis Specific) is a Protein Coding gene. Diseases associated with H2BFWT include male infertility. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Viral carcinogenesis. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2BC.
UniProtKB/Swiss-Prot for H2BFWT Gene
Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.