H2BFWT Gene
protein-coding GIFtS: 47
GCID: GC0XM103265
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|
H2B histone family, member W, testis-specific
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Aliases
for H2BFWT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| H2B Histone Family, Member W, Testis-Specific1 2 | | Histone H2B Type W-T2 | | H2B Histone Family Member W Testis-Specific3 |
Export aliases for H2BFWT gene to outside databasesPrevious GC identifers: GC0XM102038 GC0XM103071 GC0XM103153 GC0XM092921 |
Summaries
for H2BFWT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for H2BFWT:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber ineukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around whichapproximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts withlinker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This geneencodes a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5'UTR of this gene is associated with male infertility.(provided by RefSeq, Jan 2010)
UniProtKB/Swiss-Prot: H2BWT_HUMAN, Q7Z2G1Function: Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from thosecontaining conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors anddoes not participate in the assembly of mitotic chromosomes. May be important for telomere function
|
Genomic Views
for H2BFWT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the H2BFWT gene promoter:
MEF-2A MEF-2 AP-4 aMEF-2 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for H2BFWT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H2BFWT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.2 Ensembl cytogenetic band: Xq22.2 HGNC cytogenetic band: Xq22.2H2BFWT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM103265: view genomic region
(about GC identifiers)
Start:
|
103,265,719 bp from pter |
End:
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103,268,259 bp from pter |
Size:
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2,541 bases |
Orientation:
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minus strand |
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Proteins
for H2BFWT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: H2BWT_HUMAN, Q7Z2G1 (See
protein sequence)Recommended Name: Histone H2B type W-T Size: 175 amino acids; 19618 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in oneH3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus membrane. Chromosome
Miscellaneous: In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is thetarget of monoubiquitination
Miscellaneous: Ortholog in primates, but not in rodents
Secondary accessions: B1AK72 Q147W3Explore the universe of human proteins at neXtProt for H2BFWT: NX_Q7Z2G1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z2G1
H2BFWT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001002916.2
ENSEMBL proteins: ENSP00000354723
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
H2BFWT for ontologies About GeneDecksing
H2BFWT Antibody Products:
Assay Products for H2BFWT: |
Protein
Domains /
Families
for H2BFWT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
H2BFWT for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z2G1ProtoNet protein and cluster: Q7Z2G1 UniProtKB/Swiss-Prot: H2BWT_HUMAN, Q7Z2G1Similarity: Belongs to the histone H2B family |
Function
for H2BFWT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: H2BWT_HUMAN, Q7Z2G1Function: Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from thosecontaining conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors anddoes not participate in the assembly of mitotic chromosomes. May be important for telomere function
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H2BFWT
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046982 | protein heterodimerization activity |
IEA | -- |
H2BFWT for ontologies About GeneDecksing
|
Pathways & Interactions
for H2BFWT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Systemic lupus erythematosus | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for H2BFWT):
H2BFWT for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H2BFWT
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
IEA | -- |
H2BFWT for ontologies About GeneDecksing
|
Drugs & Compounds
for H2BFWT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for H2BFWT
Search CenterWatch for drugs/clinical trials and news about H2BFWT / H2BWT
|
Transcripts
for H2BFWT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for H2BFWT gene: NM_001002916.3 Unigene Cluster for H2BFWT: H2B histone family, member W, testis-specific Hs.127778 [show with all ESTs]Unigene Representative Sequence: BC0381091 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000217926(uc004elr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H2BFWT
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H2BFWT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: H2BFWT (NM_001002916) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for H2BFWT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H2BFWT |
Additional cDNA sequence: AY283370.1 BC038109.2 BC118604.1 BC121816.1 1 DOTS entry: DT.40127079 7 AceView cDNA sequences: AI143866 AA961176 NM_001002916 AY283370 BC038109 BI459475 BX095740
GeneLoc Exon Structure
|
Expression
for H2BFWT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| H2BFWT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACATATTGGA
About this image
See H2BFWT Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.127778
UniProtKB/Swiss-Prot: H2BWT_HUMAN, Q7Z2G1Tissue specificity: Testis-specific. Present in sperm cells (at protein level)
SABiosciences Custom PCR Arrays for H2BFWT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for H2BFWT
Browse OriGene validated miRNA SYBR primer pairs
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Orthologs
for H2BFWT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for H2BFWT gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for H2BFWT (if available)
TreeFam Gene Tree for H2BFWT (if available) |
Paralogs
for H2BFWT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for H2BFWT gene
- HIST1H2BA2 H2BFM2 HIST1H2BM2
18/20 SIMAP similar genes for H2BFWT using alignment to 1 protein entry: H2BWT_HUMAN(see all similar genes):H2BFM HIST3H2BB HIST1H2BD HIST1H2BL HIST1H2BM HIST1H2BN
HIST1H2BB HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BI HIST1H2BK
HIST1H2BC H2BFS HIST1H2BH HIST1H2BJ HIST1H2BO HIST2H2BE
H2BFWT for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for H2BFWT
PGOHUM00000241483 PGOHUM00000241486 PGOHUM00000241932
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Genomic Variants
for H2BFWT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for H2BFWT (103265719 - 103268259 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for H2BFWT
5 CNVs: 7756 3254 4160 68010 52902
5 Inversions: 0664 37340 0663 37341 0665
Human Gene Mutation Database (HGMD): H2BFWT
Locus Specific Mutation Databases (LSDB): H2BFWT
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H2BFWT |
|
Disorders
/ Diseases
for H2BFWT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
H2BFWT for disorders About GeneDecksing
OMIM gene information: 300507
OMIM disorders: --
6  diseases for H2BFWT: About MalaCardsmale infertility infertility systemic lupus erythematosus lupus erythematosus
azoospermia malaria
1 disease from the University of Copenhagen DISEASES database for H2BFWT:Azoospermia Human Genome Epidemiology (HuGE) Navigator: H2BFWT (1 document)
Export disorders for H2BFWT gene to outside databases
|
Publications
for H2BFWT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for H2BFWT gene integrated from 9 sources:
(articles sorted by number of sources associating them with H2BFWT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The NH2 tail of the novel histone variant H2BFWT exhibits properties distinct from conventional H2B with respect to the assembly of mitotic chromosomes. (PubMed id 16449661)1, 2 Boulard M.... Dimitrov S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel human testis-specific histone H2B encoded by the interrupted gene on the X chromosome. (PubMed id 15475252)1, 2 Churikov D.... Zalensky A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Relationship of SNP of H2BFWT gene to male infertility in a Chinese population with idiopathic spermatogenesis impairment. (PubMed id 22509975)1 Ying H.Q....Zhou-Cun A. (2012)
- Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertility. (PubMed id 19583817)1 Lee J....Lee S. (2009)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Male germline-specific histones in mouse and man. (PubMed id 15237208)1 Churikov D....Zalensky A.O. (2004)
|
External Searches for H2BFWT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing H2BFWT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing H2BFWT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H2BFWT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for H2BFWT | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for H2BFWT gene:
Search GeneIP for patents involving H2BFWT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for H2BFWT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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