Aliases for H2BFS Gene
External Ids for H2BFS Gene
Previous GeneCards Identifiers for H2BFS Gene
GeneCards Summary for H2BFS Gene
H2BFS (H2B Histone Family Member S) is a Pseudogene. Diseases associated with H2BFS include Endometrial Stromal Sarcoma. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BK.
UniProtKB/Swiss-Prot for H2BFS Gene
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.