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Aliases for H2BFS Gene

Aliases for H2BFS Gene

  • H2B Histone Family Member S (Pseudogene) 2 3 5
  • H2B Histone Family, Member S (Pseudogene) 2
  • H2B Histone Family, Member S 2
  • Histone H2B.S 4
  • H2B/S 4

External Ids for H2BFS Gene

Previous GeneCards Identifiers for H2BFS Gene

  • GC21P041494
  • GC21M041577
  • GC21P043841
  • GC21P043809
  • GC21P044985
  • GC21P030353

Summaries for H2BFS Gene

GeneCards Summary for H2BFS Gene

H2BFS (H2B Histone Family Member S (Pseudogene)) is a Pseudogene. Diseases associated with H2BFS include endometrial stromal sarcoma. Among its related pathways are Packaging Of Telomere Ends. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BH.

UniProtKB/Swiss-Prot for H2BFS Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Gene Wiki entry for H2BFS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H2BFS Gene

Genomics for H2BFS Gene

Regulatory Elements for H2BFS Gene

Enhancers for H2BFS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around H2BFS on UCSC Golden Path with GeneCards custom track

Promoters for H2BFS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around H2BFS on UCSC Golden Path with GeneCards custom track

Genomic Location for H2BFS Gene

Chromosome:
21
Start:
43,565,189 bp from pter
End:
43,565,648 bp from pter
Size:
460 bases
Orientation:
Plus strand

Genomic View for H2BFS Gene

Genes around H2BFS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2BFS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2BFS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BFS Gene

Proteins for H2BFS Gene

  • Protein details for H2BFS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57053-H2BFS_HUMAN
    Recommended name:
    Histone H2B type F-S
    Protein Accession:
    P57053
    Secondary Accessions:
    • A0AVF9
    • Q5R2W0

    Protein attributes for H2BFS Gene

    Size:
    126 amino acids
    Molecular mass:
    13944 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

neXtProt entry for H2BFS Gene

Proteomics data for H2BFS Gene at MOPED

Post-translational modifications for H2BFS Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys 121
  • Glycosylation at Ser 113
  • Modification sites at PhosphoSitePlus

Other Protein References for H2BFS Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for H2BFS Gene

Domains & Families for H2BFS Gene

Gene Families for H2BFS Gene

Protein Domains for H2BFS Gene

Suggested Antigen Peptide Sequences for H2BFS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57053

UniProtKB/Swiss-Prot:

H2BFS_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BFS: view

Function for H2BFS Gene

Molecular function for H2BFS Gene

GENATLAS Biochemistry:
core histone family H2B,replication dependent,S,belonging to a microcluster located between the main terminal and proximal clusters on chromosome 6p
UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
UniProtKB/Swiss-Prot Function:
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Gene Ontology (GO) - Molecular Function for H2BFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IBA --
genes like me logo Genes that share ontologies with H2BFS: view

Phenotypes for H2BFS Gene

genes like me logo Genes that share phenotypes with H2BFS: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H2BFS Gene

Localization for H2BFS Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BFS Gene

Nucleus. Chromosome.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for H2BFS Gene

Pathways & Interactions for H2BFS Gene

genes like me logo Genes that share pathways with H2BFS: view

Pathways by source for H2BFS Gene

1 GeneGo (Thomson Reuters) pathway for H2BFS Gene

Interacting Proteins for H2BFS Gene

Selected Interacting proteins: P57053-H2BFS_HUMAN for H2BFS Gene via I2D

Symbol External ID(s) Details
ESR2

Gene Ontology (GO) - Biological Process for H2BFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019731 antibacterial humoral response IDA 12860195
genes like me logo Genes that share ontologies with H2BFS: view

No data available for SIGNOR curated interactions for H2BFS Gene

Drugs & Compounds for H2BFS Gene

(10) Drugs for H2BFS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for H2BFS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with H2BFS: view

Transcripts for H2BFS Gene

mRNA/cDNA for H2BFS Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for H2BFS Gene

No ASD Table

Relevant External Links for H2BFS Gene

GeneLoc Exon Structure for
H2BFS
ECgene alternative splicing isoforms for
H2BFS

Expression for H2BFS Gene

mRNA expression in normal human tissues for H2BFS Gene

mRNA differential expression in normal tissues according to GTEx for H2BFS Gene

This gene is overexpressed in Whole Blood (x9.6).

Protein differential expression in normal tissues from HIPED for H2BFS Gene

This gene is overexpressed in Blymphocyte (30.0) and Retina (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for H2BFS Gene



genes like me logo Genes that share expression patterns with H2BFS: view

Protein tissue co-expression partners for H2BFS Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for H2BFS Gene

Orthologs for H2BFS Gene

Evolution for H2BFS Gene

ENSEMBL:
Gene Tree for H2BFS (if available)
TreeFam:
Gene Tree for H2BFS (if available)

No data available for Orthologs for H2BFS Gene

Paralogs for H2BFS Gene

genes like me logo Genes that share paralogs with H2BFS: view

Variants for H2BFS Gene

Relevant External Links for H2BFS Gene

HapMap Linkage Disequilibrium report
H2BFS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for H2BFS Gene

Disorders for H2BFS Gene

MalaCards: The human disease database

(1) MalaCards diseases for H2BFS Gene - From: GeneCards

Disorder Aliases PubMed IDs
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
- elite association - COSMIC cancer census association via MalaCards
Search H2BFS in MalaCards View complete list of genes associated with diseases

Relevant External Links for H2BFS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
H2BFS
genes like me logo Genes that share disorders with H2BFS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for H2BFS Gene

Publications for H2BFS Gene

  1. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4 23 67
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Regulation of error-prone translesion synthesis by Spartan/C1orf124. (PMID: 23254330) Kim M.S. … Machida Y.J. (Nucleic Acids Res. 2013) 3
  5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PMID: 23398456) Bett J.S. … Hay R.T. (Biochem. J. 2013) 3

Products for H2BFS Gene

Sources for H2BFS Gene

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