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H2BFS Gene

pseudogene   GIFtS: 37
GCID: GC21P044985

H2B Histone Family, Member S (Pseudogene)

(Previous names: H2B histone family, member S)
  See H2BFS-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
H2B Histone Family, Member S (Pseudogene)1 2
H2B Histone Family, Member S1
H2B Histone Family S Member11
H2B/s3
Histone H2B.S3

External Ids:    HGNC: 47621   Entrez Gene: 541452   Ensembl: ENSG000002342897   UniProtKB: P570533   

Export aliases for H2BFS gene to outside databases

Previous GC identifers: GC21P041494 GC21M041577 GC21P043841 GC21P043809 GC21P030353


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for H2BFS Gene:
H2BFS (H2B histone family, member S (pseudogene)) is a pseudogene. Diseases associated with H2BFS include acute myeloid leukemia. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot: H2BFS_HUMAN, P57053
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling
Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial
barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for H2BFS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for H2BFS
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

   Search Chromatin IP Primers for H2BFS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat H2BFS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
H2BFS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H2BFS gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P044985:   GeneLoc Nature:405,311-319
Start:
44,985,070 bp from pter       30,494,512 bp from centromere
End:
44,985,529 bp from pter 30,494,892 bp from centromere
Size:
460 bases 381 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AB041017
genomic clones: KB953G5 KB161B12


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: H2BFS_HUMAN, P57053 (See protein sequence)
Recommended Name: Histone H2B type F-S  
Size: 126 amino acids; 13944 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Secondary accessions: A0AVF9 Q5R2W0

Explore the universe of human proteins at neXtProt for H2BFS: NX_P57053

Post-translational modifications: 

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as
    a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a
    large set of exons1
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin
    condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation
    with somatic hypermutation and immunoglobulin class-switch recombination1
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular
    glucose, and associates with transcribed genes (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Ubiquitination2 at Lys6, Lys44, Lys47, Lys58, Lys109, Lys117, Lys121
  • Glycosylation2 at Ser113
  • Modification sites at PhosphoSitePlus
  • Reactome Protein details: P57053

    H2BFS Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for H2BFS

     
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    antibodies-online proteins for H2BFS 

     
    antibodies-online peptides for H2BFS

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    antibodies-online antibodies for H2BFS (2 products) 

    H2BFS Assay Products:

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    Cloud-Clone Corp. ELISAs for H2BFS
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RIH: Histones / Replication-independent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P57053

    ProtoNet protein and cluster: P57053

    UniProtKB/Swiss-Prot: H2BFS_HUMAN, P57053
    Similarity: Belongs to the histone H2B family


    Find genes that share domains with H2BFS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2BFS_HUMAN, P57053
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling
    Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial
    barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

         Genatlas biochemistry entry for H2BFS:
    core histone family H2B,replication dependent,S,belonging to a microcluster located between the main terminal and
    proximal clusters on chromosome 6p

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with H2BFS           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for H2BFS:
     G2 arrest  Increased G2M DNA content  Increased cell size 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for H2BFS

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H2BFS_HUMAN, P57053: Nucleus. Chromosome

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with H2BFS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for H2BFS About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Condensation of Prophase Chromosomes0.78
    RNA Polymerase I Chain Elongation0.78
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    RNA Polymerase I Promoter Clearance0.78
    Amyloids0.68
    RNA Polymerase I Promoter Opening0.78
    Mitotic Prophase0.56
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74


    Find genes that share SuperPaths with H2BFS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for H2BFS
        Signal transduction Activin A signaling regulation

    Selected Reactome Pathways for H2BFS (see all 15)
        NoRC negatively regulates rRNA expression
    Deposition of new CENPA-containing nucleosomes at the centromere
    Meiotic recombination
    formation of the beta-catenin:TCF transactivating complex
    Oxidative Stress Induced Senescence


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for H2BFS
    Interactions:

        Search GeneGlobe Interaction Network for H2BFS

    1 Interacting protein for H2BFS (P570533) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0021762substantia nigra development IEP--
    GO:0042742defense response to bacterium IEA--

    Find genes that share ontologies with H2BFS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for H2BFS

    Selected Novoseek inferred chemical compound relationships for H2BFS gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 63 21 16630806 (1), 12475245 (1), 15933374 (1), 17988933 (1) (see all 22)
    protamine 30 1 1514582 (1)
    8-oxo-dg 18.3 2 10898600 (1)
    daunorubicin 16.5 1 19394329 (1), 15059665 (1)
    hoechst 33342 14.6 1 12870855 (1)
    valproate 10.2 1 19458058 (1)
    cytosine 8.38 2 12438235 (1), 16049569 (1)
    oxygen 4.6 2 15975552 (1), 18452314 (1)
    glucose 3.28 3 1917561 (1), 1716156 (1), 8080596 (1)
    acetaldehyde 1.71 1 8080596 (1)



    Find genes that share compounds with H2BFS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for H2BFS gene: 
    NM_017445.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464664(uc002zdj.1) ENST00000599962
    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat H2BFS

    4 AceView cDNA sequences:

    NM_017445 AA380653 AA405357 AI022008 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    H2BFS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    H2BFS Expression
    About this image

    H2BFS Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
        Custom PCR Arrays for H2BFS
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2BFS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for H2BFS (if available)
    TreeFam Gene Tree for H2BFS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for H2BFS gene
    Selected SIMAP similar genes for H2BFS using alignment to 1 protein entry:     H2BFS_HUMAN(see all similar genes):
    HIST1H2BB    HIST1H2BD    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH
    HIST1H2BI    HIST1H2BJ    HIST1H2BK    HIST1H2BM    HIST1H2BN    HIST1H2BO
    HIST2H2BE    HIST2H2BF    HIST3H2BB    HIST1H2BC    HIST1H2BL    HIST2H2BC

    Find genes that share paralogs with H2BFS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing H2BFS
    DNA2.0 Custom Variant and Variant Library Synthesis for H2BFS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for H2BFS:    
    About MalaCards
    acute myeloid leukemia


    Find genes that share disorders with H2BFS           About GenesLikeMe

    5 Novoseek inferred disease relationships for H2BFS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 12.3 1 16093828 (1)
    shock 0 2 11327322 (1), 17022634 (1)
    cancer lung 0 1 17424862 (1)
    breast cancer 0 1 16407273 (1)
    tumors 0 3 15134431 (1), 15547685 (1), 16489441 (1)


    Export disorders for H2BFS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for H2BFS gene, integrated from 10 sources (see all 169):
    (articles sorted by number of sources associating them with H2BFS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PubMed id 12757711)1, 2, 9 Cheung W.L.... Allis C.D. (Cell 2003)
    2. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (Cell 2006)
    3. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (Mol. Cell. Proteomics 2006)
    4. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (Mol. Cell. Biochem. 2005)
    5. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (Mol. Cell 2005)
    6. Antimicrobial polypeptides of the human colonic epithelium. (PubMed id 15019208)1, 2 Howell S.J.... Bevins C.L. (Peptides 2003)
    7. Antimicrobial peptides in the first line defence of human colon mucosa. (PubMed id 12860195)1, 2 Tollin M....Agerberth B. (Peptides 2003)
    8. Endotoxin-neutralizing antimicrobial proteins of the human placenta. (PubMed id 11859126)1, 2 Kim H.S.... Kim S.C. (J. Immunol. 2002)
    9. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    10. Biochemical and antibacterial analysis of human wound and blister fluid. (PubMed id 8620898)1, 2 Frohm M.... Boman H.G. (Eur. J. Biochem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54145 HGNC: 4762 AceView: H2BFS Ensembl:ENSG00000234289 euGenes: HUgn54145
    ECgene: H2BFS H-InvDB: H2BFS

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for H2BFS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for H2BFS gene:
    Search GeneIP for patents involving H2BFS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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