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H2B histone family, member S (pseudogene)(Previous names: H2B histone family, member S )
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Aliases
for H2BFS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
|
| Aliases |
|---|
| H2B Histone Family, Member S (Pseudogene)1 2 | | H2B Histone Family, Member S1 | | H2B Histone Family S Member11 | | H2B/S1 | | Histone H2B.S3 |
Export aliases for H2BFS gene to outside databasesPrevious GC identifers: GC21P041494 GC21M041577 GC21P043841 GC21P043809 GC21P030353 |
Summaries
for H2BFS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: H2BFS_HUMAN, P57053Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set ofpost-translational modifications of histones, also called histone code, and nucleosome remodelingFunction: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier ofthe colonic epithelium, and to the bactericidal activity of amniotic fluid
Gene Wiki entry for H2BFS
|
Genomic Views
for H2BFS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics, Whole Chromsome Sequence According to
Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
|
| GC21P044985: |
GeneLoc |
Nature:405,311-319 |
Start:
|
44,985,120 bp from pter |
30,494,512 bp from centromere |
End:
|
44,985,500 bp from pter |
30,494,892 bp from centromere |
Size:
|
381 bases |
381 bases |
Orientation:
|
plus strand |
plus strand |
Proteins
for H2BFS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: H2BFS_HUMAN, P57053 (See
protein sequence)Recommended Name: Histone H2B type F-S Size: 126 amino acids; 13944 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in oneH3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Secondary accessions: A0AVF9 Q5R2W0Explore the universe of human proteins at neXtProt for H2BFS: NX_P57053
Post-translational modifications:
Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79'(H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly,monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptionalactivation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperativelywith the FACT dimer to stimulate elongation by RNA polymerase II1
Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation.Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatichypermutation and immunoglobulin class-switch recombination1
GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose,and associates with transcribed genes (By similarity)1
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks activepromoters and enhancers and confers resistance to transcriptional repressors. It is also associated withpost-meiotically activated genes on autosomes1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P57053
H2BFS Protein expression data from MOPED and PaxDb: --
Reactome Protein details: P57053
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
H2BFS for ontologies About GeneDecksing
H2BFS Antibody Products:
Assay Products for H2BFS: |
Protein
Domains /
Families
for H2BFS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
H2BFS for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P57053ProtoNet protein and cluster: P57053 UniProtKB/Swiss-Prot: H2BFS_HUMAN, P57053Similarity: Belongs to the histone H2B family |
Function
for H2BFS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: H2BFS_HUMAN, P57053Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set ofpost-translational modifications of histones, also called histone code, and nucleosome remodelingFunction: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier ofthe colonic epithelium, and to the bactericidal activity of amniotic fluid Genatlas biochemistry entry for H2BFS:core histone family H2B,replication dependent,S,belonging to a microcluster located between the main terminal andproximal clusters on chromosome 6p
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046982 | protein heterodimerization activity |
IEA | -- |
H2BFS for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for H2BFS:
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Pathways & Interactions
for H2BFS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Meiotic Synapsis | | | 2 | RSF Complex Binds the Centromere. | | | 3 | Signal transduction Activin A signaling regulation | | | 4 | Formation of Meiotic Holliday Junction | | | 5 | Disease | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  EMD Millipore Pathways for H2BFS
1  GeneGo (Thomson Reuters) Pathway for H2BFS
5/17 
Reactome Pathways for H2BFS (see all 17)
H2BFS for pathways About GeneDecksing
Interactions:
 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H2BFS
1 Interacting protein for H2BFS (P570533) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
IEA | -- | | GO:0042742 | defense response to bacterium |
IEA | -- |
H2BFS for ontologies About GeneDecksing
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Drugs & Compounds
for H2BFS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
H2BFS for compounds About GeneDecksing
 Browse Tocris compounds for H2BFS
10/18 Novoseek chemical compound relationships for H2BFS gene (see all 18) About this table
Search CenterWatch for drugs/clinical trials and news about H2BFS
|
Transcripts
for H2BFS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for H2BFS gene: NM_017445.1 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000464664(uc002zdj.1)
4 AceView cDNA sequences: NM_017445 AA380653 AA405357 AI022008
GeneLoc Exon Structure
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Expression
for H2BFS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| H2BFS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for H2BFS
SABiosciences Custom PCR Arrays for H2BFS
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for H2BFS
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat H2BFS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H2BFS | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H2BFS |
Orthologs
for H2BFS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for H2BFS (if available)
TreeFam Gene Tree for H2BFS (if available) |
Paralogs
for H2BFS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for H2BFS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for H2BFS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
H2BFS for disorders About GeneDecksing
20/22  diseases for H2BFS (see all 22): About MalaCardsendometrial stromal sarcoma heart block lupus erythematosus male infertility
acute myeloid leukemia herpes simplex myeloid leukemia adrenocortical tumor
infertility huntington's disease sarcoma breast cancer
medulloblastoma colon cancer breast carcinoma leukemia
lung cancer cholesterol schizophrenia immunodeficiency
5 Novoseek disease relationships for H2BFS gene About this table
Export disorders for H2BFS gene to outside databases
|
Publications
for H2BFS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for H2BFS gene, integrated from 9 sources (see all 167):
(articles sorted by number of sources associating them with H2BFS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PubMed id 12757711)1, 2, 9 Cheung W.L.... Allis C.D. (2003)
- Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (2006)
- Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (2006)
- Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (2005)
- Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
- Antimicrobial polypeptides of the human colonic epithelium. (PubMed id 15019208)1, 2 Howell S.J.... Bevins C.L. (2003)
- Antimicrobial peptides in the first line defence of human colon mucosa. (PubMed id 12860195)1, 2 Tollin M....Agerberth B. (2003)
- Endotoxin-neutralizing antimicrobial proteins of the human placenta. (PubMed id 11859126)1, 2 Kim H.S.... Kim S.C. (2002)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
- Biochemical and antibacterial analysis of human wound and blister fluid. (PubMed id 8620898)1, 2 Frohm M.... Boman H.G. (1996)
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External Searches for H2BFS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing H2BFS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing H2BFS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H2BFS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for H2BFS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for H2BFS gene:
Search GeneIP for patents involving H2BFS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for H2BFS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | | | |
 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat H2BFS | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H2BFS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H2BFS | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H2BFS | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H2BFS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H2BFS |
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 |  |  |  | |
| | | | Search Tocris compounds for H2BFS |
| |  |  |  |  | | | | |
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 | | | H2BFS Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for H2BFS |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat H2BFS |
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Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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