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Aliases for H2BFS Gene

Aliases for H2BFS Gene

  • H2B Histone Family, Member S (Pseudogene) 2 3
  • H2B Histone Family, Member S 2
  • Histone H2B.S 4
  • H2B/S 4

External Ids for H2BFS Gene

Previous GeneCards Identifiers for H2BFS Gene

  • GC21P041494
  • GC21M041577
  • GC21P043841
  • GC21P043809
  • GC21P044985
  • GC21P030353

Summaries for H2BFS Gene

GeneCards Summary for H2BFS Gene

H2BFS (H2B Histone Family, Member S (Pseudogene)) is a Pseudogene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for H2BFS Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for H2BFS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H2BFS Gene

Genomics for H2BFS Gene

Genomic Location for H2BFS Gene

Start:
43,565,189 bp from pter
End:
43,565,648 bp from pter
Size:
460 bases
Orientation:
Plus strand

Genomic View for H2BFS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for H2BFS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BFS Gene

No data available for Regulatory Elements for H2BFS Gene

Proteins for H2BFS Gene

  • Protein details for H2BFS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57053-H2BFS_HUMAN
    Recommended name:
    Histone H2B type F-S
    Protein Accession:
    P57053
    Secondary Accessions:
    • A0AVF9
    • Q5R2W0

    Protein attributes for H2BFS Gene

    Size:
    126 amino acids
    Molecular mass:
    13944 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

neXtProt entry for H2BFS Gene

Proteomics data for H2BFS Gene at MOPED

Post-translational modifications for H2BFS Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys6, Lys44, Lys47, Lys58, Lys109, Lys117, and Lys121
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for H2BFS Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for H2BFS Gene

Domains for H2BFS Gene

Gene Families for H2BFS Gene

HGNC:
  • RIH :Histones / Replication-independent

Protein Domains for H2BFS Gene

Suggested Antigen Peptide Sequences for H2BFS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57053

UniProtKB/Swiss-Prot:

H2BFS_HUMAN :
  • P57053
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BFS: view

Function for H2BFS Gene

Molecular function for H2BFS Gene

GENATLAS Biochemistry: core histone family H2B,replication dependent,S,belonging to a microcluster located between the main terminal and proximal clusters on chromosome 6p
UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
UniProtKB/Swiss-Prot Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Ontology (GO) - Molecular Function for H2BFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with H2BFS: view

Phenotypes for H2BFS Gene

GenomeRNAi human phenotypes for H2BFS:
genes like me logo Genes that share phenotypes with H2BFS: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for H2BFS Gene

Localization for H2BFS Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BFS Gene

Nucleus. Chromosome.

Gene Ontology (GO) - Cellular Components for H2BFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005615 extracellular space IDA 12860195
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16319397
genes like me logo Genes that share ontologies with H2BFS: view

No data available for Subcellular locations from COMPARTMENTS for H2BFS Gene

Pathways for H2BFS Gene

genes like me logo Genes that share pathways with H2BFS: view

Pathways by source for H2BFS Gene

26 Reactome pathways for H2BFS Gene
1 GeneGo (Thomson Reuters) pathway for H2BFS Gene

Interacting Proteins for H2BFS Gene

Selected Interacting proteins: P57053-H2BFS_HUMAN for H2BFS Gene via I2D

Symbol External ID(s) Details
ESR2

Gene Ontology (GO) - Biological Process for H2BFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0019731 antibacterial humoral response IDA 12860195
GO:0021762 substantia nigra development IEP 22926577
GO:0050830 defense response to Gram-positive bacterium IDA 12860195
genes like me logo Genes that share ontologies with H2BFS: view

Compounds for H2BFS Gene

(18) Novoseek inferred chemical compound relationships for H2BFS Gene

Compound -log(P) Hits PubMed IDs
lysine 63 22
protamine 30 1
8-oxo-dg 18.3 1
daunorubicin 16.5 2
hoechst 33342 14.6 1
genes like me logo Genes that share compounds with H2BFS: view

Transcripts for H2BFS Gene

mRNA/cDNA for H2BFS Gene

(4) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for H2BFS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for H2BFS Gene

No ASD Table

Relevant External Links for H2BFS Gene

GeneLoc Exon Structure for
H2BFS
ECgene alternative splicing isoforms for
H2BFS

Expression for H2BFS Gene

mRNA expression in normal human tissues for H2BFS Gene

mRNA differential expression in normal tissues according to GTEx for H2BFS Gene

This gene is overexpressed in Whole Blood (9.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for H2BFS Gene

genes like me logo Genes that share expressions with H2BFS: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for H2BFS Gene

Orthologs for H2BFS Gene

Evolution for H2BFS Gene

ENSEMBL:
Gene Tree for H2BFS (if available)
TreeFam:
Gene Tree for H2BFS (if available)

No data available for Orthologs for H2BFS Gene

Paralogs for H2BFS Gene

genes like me logo Genes that share paralogs with H2BFS: view

No data available for Paralogs for H2BFS Gene

Variants for H2BFS Gene

Relevant External Links for H2BFS Gene

HapMap Linkage Disequilibrium report
H2BFS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for H2BFS Gene

Disorders for H2BFS Gene

(5) Novoseek inferred disease relationships for H2BFS Gene

Disease -log(P) Hits PubMed IDs
lupus erythematosus systemic 12.3 1
shock 0 2
cancer lung 0 1
breast cancer 0 1
tumors 0 3
genes like me logo Genes that share disorders with H2BFS: view

No data available for UniProtKB/Swiss-Prot for H2BFS Gene

Publications for H2BFS Gene

  1. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4 23
  2. Biochemical and antibacterial analysis of human wound and blister fluid. (PMID: 8620898) Frohm M. … Boman H.G. (Eur. J. Biochem. 1996) 3 4
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  4. Endotoxin-neutralizing antimicrobial proteins of the human placenta. (PMID: 11859126) Kim H.S. … Kim S.C. (J. Immunol. 2002) 3 4
  5. Antimicrobial peptides in the first line defence of human colon mucosa. (PMID: 12860195) Tollin M. … Agerberth B. (Peptides 2003) 3 4

Products for H2BFS Gene

Sources for H2BFS Gene

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