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Aliases for H2BFM Gene

Aliases for H2BFM Gene

  • H2B Histone Family Member M 2 3 5
  • H2B Histone Family, Member M 2 3
  • Histone H2B.S 3 4
  • H2B/S 3 4

External Ids for H2BFM Gene

Previous GeneCards Identifiers for H2BFM Gene

  • GC0XP103098
  • GC0XP103177
  • GC0XP103268
  • GC0XP092950

Summaries for H2BFM Gene

Entrez Gene Summary for H2BFM Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family. [provided by RefSeq, Nov 2015]

GeneCards Summary for H2BFM Gene

H2BFM (H2B Histone Family Member M) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Viral carcinogenesis. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is H2BFWT.

UniProtKB/Swiss-Prot for H2BFM Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H2BFM Gene

Genomics for H2BFM Gene

Regulatory Elements for H2BFM Gene

Genomic Location for H2BFM Gene

104,039,909 bp from pter
104,042,454 bp from pter
2,546 bases
Plus strand

Genomic View for H2BFM Gene

Genes around H2BFM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H2BFM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H2BFM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2BFM Gene

Proteins for H2BFM Gene

  • Protein details for H2BFM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone H2B type F-M
    Protein Accession:
    Secondary Accessions:
    • A6NP82

    Protein attributes for H2BFM Gene

    154 amino acids
    Molecular mass:
    17001 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is the target of monoubiquitination.

neXtProt entry for H2BFM Gene

Proteomics data for H2BFM Gene at MOPED

Post-translational modifications for H2BFM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for H2BFM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H2BFM Gene

Domains & Families for H2BFM Gene

Gene Families for H2BFM Gene

Protein Domains for H2BFM Gene

Suggested Antigen Peptide Sequences for H2BFM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the histone H2B family.
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with H2BFM: view

Function for H2BFM Gene

Molecular function for H2BFM Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for H2BFM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IBA --
genes like me logo Genes that share ontologies with H2BFM: view
genes like me logo Genes that share phenotypes with H2BFM: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H2BFM Gene

Localization for H2BFM Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2BFM Gene

Nucleus. Chromosome.

Subcellular locations from

Jensen Localization Image for H2BFM Gene COMPARTMENTS Subcellular localization image for H2BFM gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for H2BFM Gene

Pathways & Interactions for H2BFM Gene

genes like me logo Genes that share pathways with H2BFM: view

Pathways by source for H2BFM Gene

Gene Ontology (GO) - Biological Process for H2BFM Gene


No data available for SIGNOR curated interactions for H2BFM Gene

Drugs & Compounds for H2BFM Gene

No Compound Related Data Available

Transcripts for H2BFM Gene

mRNA/cDNA for H2BFM Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for H2BFM Gene

H2B histone family, member M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for H2BFM Gene

No ASD Table

Relevant External Links for H2BFM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for H2BFM Gene

mRNA expression in normal human tissues for H2BFM Gene

mRNA differential expression in normal tissues according to GTEx for H2BFM Gene

This gene is overexpressed in Testis (x24.4).

Protein differential expression in normal tissues from HIPED for H2BFM Gene

This gene is overexpressed in Colon muscle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for H2BFM Gene

SOURCE GeneReport for Unigene cluster for H2BFM Gene Hs.376474

genes like me logo Genes that share expression patterns with H2BFM: view

Protein tissue co-expression partners for H2BFM Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for H2BFM Gene

Orthologs for H2BFM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for H2BFM Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia H2bfm 35
  • 59.69 (n)
  • 52.33 (a)
H2bfm 16
H2bfm 36
  • 26 (a)
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
-- 36
  • 47 (a)
-- 36
  • 26 (a)
-- 36
  • 40 (a)
-- 36
  • 35 (a)
-- 36
  • 43 (a)
(Canis familiaris)
Mammalia -- 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
-- 36
  • 37 (a)
(Pan troglodytes)
Mammalia -- 36
  • 72 (a)
(Gallus gallus)
Aves -- 36
  • 40 (a)
(Danio rerio)
Actinopterygii zgc:171759 36
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta His2B:CG33910 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea his-11 36
  • 43 (a)
his-15 36
  • 43 (a)
his-20 36
  • 42 (a)
his-22 36
  • 42 (a)
his-29 36
  • 43 (a)
his-34 36
  • 43 (a)
his-39 36
  • 45 (a)
his-4 36
  • 42 (a)
his-41 36
  • 41 (a)
his-44 36
  • 43 (a)
his-48 36
  • 43 (a)
his-52 36
  • 42 (a)
his-54 36
  • 37 (a)
his-58 36
  • 43 (a)
his-62 36
  • 43 (a)
his-66 36
  • 43 (a)
his-8 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HTB1 36
  • 34 (a)
HTB2 36
  • 34 (a)
Species with no ortholog for H2BFM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for H2BFM Gene

Gene Tree for H2BFM (if available)
Gene Tree for H2BFM (if available)

Paralogs for H2BFM Gene

Paralogs for H2BFM Gene Pseudogenes for H2BFM Gene

genes like me logo Genes that share paralogs with H2BFM: view

Variants for H2BFM Gene

Sequence variations from dbSNP and Humsavar for H2BFM Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2187725 -- 104,040,695(-) GGACA(C/T)GAAAC intron-variant
rs2301384 -- 104,040,193(-) GCCCT(A/G)GTGAA reference, stop-gained
rs3213517 -- 104,040,976(-) TTTAT(G/T)TAGCC intron-variant
rs3213518 -- 104,040,823(-) tctgg(A/G)aaatc intron-variant
rs3213519 -- 104,040,753(-) ATCAT(C/G)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for H2BFM Gene

Variant ID Type Subtype PubMed ID
dgv2459e1 CNV Complex 17122850
nsv469772 CNV Complex 16826518
nsv519626 CNV Gain 19592680
nsv7453 OTHER Inversion 18451855
esv1007027 OTHER Inversion 20482838
dgv63n47 OTHER Inversion 21111241
dgv2460e1 CNV Complex 17122850
dgv5n1 OTHER Inversion 15895083
esv22275 CNV Gain 19812545
nsv508787 CNV Insertion 20534489

Variation tolerance for H2BFM Gene

Gene Damage Index Score: 9.12; 87.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for H2BFM Gene

Disorders for H2BFM Gene

Relevant External Links for H2BFM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for H2BFM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for H2BFM Gene

Publications for H2BFM Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. A unified phylogeny-based nomenclature for histone variants. (PMID: 22650316) Talbert P.B. … Henikoff S. (Epigenetics Chromatin 2012) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. (PMID: 16226712) Niture S.K. … Srivenugopal K.S. (Biochem. Biophys. Res. Commun. 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for H2BFM Gene

Sources for H2BFM Gene