H2BFM Gene
protein-coding GIFtS: 41
GCID: GC0XP103268
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H2B histone family, member M
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Aliases
for H2BFM gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| H2B Histone Family, Member M1 2 | | Histone H2B.S2 3 | | H2B/S1 | | Histone H2B Type F-M2 |
Export aliases for H2BFM gene to outside databasesPrevious GC identifers: GC0XP103098 GC0XP103177 GC0XP092950 |
Summaries
for H2BFM gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: H2BFM_HUMAN, P0C1H6Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set ofpost-translational modifications of histones, also called histone code, and nucleosome remodeling
|
Genomic Views
for H2BFM gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the H2BFM gene promoter:
MEF-2A MEF-2 AP-4 aMEF-2 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for H2BFM
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H2BFM |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.2 Ensembl cytogenetic band: Xq22.2 HGNC cytogenetic band: Xq22.2H2BFM Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP103268: view genomic region
(about GC identifiers)
Start:
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103,268,269 bp from pter |
End:
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103,297,021 bp from pter |
Size:
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28,753 bases |
Orientation:
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plus strand |
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Proteins
for H2BFM gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: H2BFM_HUMAN, P0C1H6 (See
protein sequence)Recommended Name: Histone H2B type F-M Size: 257 amino acids; 28267 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in oneH3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Miscellaneous: In contrast to other H2B histones, it does not contain the conserved residue in C-terminus that is thetarget of monoubiquitination
Secondary accessions: A6NP82Explore the universe of human proteins at neXtProt for H2BFM: NX_P0C1H6
H2BFM Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001157888.1
ENSEMBL proteins: ENSP00000347119 ENSP00000402466 ENSP00000243297
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
H2BFM for ontologies About GeneDecksing
H2BFM Antibody Products:
Assay Products for H2BFM: |
Protein
Domains /
Families
for H2BFM gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
H2BFM for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0C1H6ProtoNet protein and cluster: P0C1H6 UniProtKB/Swiss-Prot: H2BFM_HUMAN, P0C1H6Similarity: Belongs to the histone H2B family |
Function
for H2BFM gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: H2BFM_HUMAN, P0C1H6Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set ofpost-translational modifications of histones, also called histone code, and nucleosome remodeling
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H2BFM (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H2BFM
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: H2BFM (NM_001164416) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for H2BFM | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat H2BFM |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2BFM |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046982 | protein heterodimerization activity |
IEA | -- |
H2BFM for ontologies About GeneDecksing
|
Pathways & Interactions
for H2BFM gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Systemic lupus erythematosus | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for H2BFM):
H2BFM for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H2BFM
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for H2BFM (ENSP000002432974) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
IEA | -- |
H2BFM for ontologies About GeneDecksing
|
Drugs & Compounds
for H2BFM gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for H2BFM
Search CenterWatch for drugs/clinical trials and news about H2BFM
|
Transcripts
for H2BFM gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for H2BFM gene: NM_001164416.1 Unigene Cluster for H2BFM: H2B histone family, member M Hs.376474 [show with all ESTs]Unigene Representative Sequence: NM_0011644163 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355016(uc004els.2) ENST00000417637 ENST00000243297
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H2BFM (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H2BFM
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: H2BFM (NM_001164416) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for H2BFM | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat H2BFM |
Additional cDNA sequence: AK093522.1 1 DOTS entry: DT.99998582 4 AceView cDNA sequences: AK093522 AI018051 AX748182 AI827900
GeneLoc Exon Structure
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Expression
for H2BFM gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| H2BFM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACAAAAGC
About this image
See H2BFM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for H2BFM
SOURCE GeneReport for Unigene cluster: Hs.376474
SABiosciences Custom PCR Arrays for H2BFM
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat H2BFM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H2BFM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H2BFM | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2BFM |
Orthologs
for H2BFM gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for H2BFM gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for H2BFM (if available)
TreeFam Gene Tree for H2BFM (if available) |
Paralogs
for H2BFM gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for H2BFM gene
- HIST1H2BA2 HIST1H2BM2 H2BFWT2
18/20 SIMAP similar genes for H2BFM using alignment to 2 protein entries: H2BFM_HUMAN (see all proteins)
(see all similar genes):HIST2H2BF HIST1H2BL HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD
HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BI HIST1H2BJ HIST1H2BK
HIST1H2BM HIST1H2BN HIST2H2BE HIST3H2BB HIST1H2BH HIST1H2BO
H2BFM for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for H2BFM
PGOHUM00000241933
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Genomic Variants
for H2BFM gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for H2BFM (103268269 - 103297021 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for H2BFM
4 CNVs: 3254 4160 68010 52903
4 Inversions: 0664 37340 37341 0665 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H2BFM |
|
Disorders
/ Diseases
for H2BFM gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
H2BFM for disorders About GeneDecksing
3  diseases for H2BFM: About MalaCardssystemic lupus erythematosus lupus erythematosus malaria
Export disorders for H2BFM gene to outside databases
|
Publications
for H2BFM gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for H2BFM gene integrated from 9 sources:
(articles sorted by number of sources associating them with H2BFM) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. (PubMed id 16226712)1 Niture S.K....Srivenugopal K.S. (2005)
|
External Searches for H2BFM gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing H2BFM gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing H2BFM gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H2BFM gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for H2BFM | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for H2BFM gene:
Search GeneIP for patents involving H2BFM
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for H2BFM gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat H2BFM | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H2BFM | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H2BFM | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H2BFM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H2BFM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H2BFM |
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 |  |  |  | |
| | | | Search Tocris compounds for H2BFM |
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 | | | H2BFM Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2BFM |
|  |  |  | | | | Search ThermoFisher Antibodies for H2BFM |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat H2BFM |
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