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H2AFZ Gene

protein-coding GIFtS: 60

GC04M101116

H2A histone family, member Z
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: H2AZ)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
H2A.z ^²
H2A/z ^², ³
H2AZ ^², ³
MGC117173 ^²

Descriptions
H2A histone family, member Z ^²
H2AZ histone ^²

External Ids
HGNC: 4741¹
Entrez Gene: 3015²
UniProtKB: P0C0S5³
Ensembl: ENSG00000164032⁷

Search outside databases for aliases for H2AFZ gene

Previous GC identifers: GC04M101261 GC04M101327 GC04M101226

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for H2AFZ:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the

chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around

a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The

chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA

between the nucleosomes to form higher order chromatin structures. This gene encodes a

replication-independent member of the histone H2A family that is distinct from other members of

the family. Studies in mice have shown that this particular histone is required for embryonic

development and indicate that lack of functional histone H2A leads to embryonic lethality.

[provided by RefSeq]

UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5

Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular

machineries which require DNA as a template. Histones thereby play a central role in transcription

regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated

via a complex set of post-translational modifications of histones, also called histone code, and

nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be

required for chromosome segregation during cell division

Gene Wiki entry for H2AFZ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the H2AFZ gene

Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23

H2AFZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M101116: (about GC identifiers)

Start:	101,088,265 bp from pter
End:	101,090,535 bp from pter
Size:	2,271 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5 (See protein sequence)

Recommended Name: Histone H2A.Z

Size: 128 amino acids; 13553 Da

Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4

assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps

approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ

interacts with INCENP (By similarity)

Subcellular location: Nucleus

Mass spectrometry: Mass=13413.4; Method=Electrospray; Range=2-128; Note=Monoisotopic, not modified;

Source=PubMed:16457589;

PDB structures from and Proteopedia :

1F66 (3D)

Secondary accessions: P17317 Q6I9U0

Post-translational modifications:

Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression¹

Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By

similarity)¹

Not phosphorylated (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002097.1

ENSEMBL proteins:

ENSP00000296417

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant H2AFZ Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (H2A.Z, Htz1, Histone H2A.Z)
	Human Recombinant Proteins from Abnova (H2AFZ)

OriGene Purified Recombinant Human Protein: H2AFZ

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005694	chromosome	IEA	--

About this table

Antibodies for H2AFZ:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of H2AFZ
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for H2AFZ (Histone H2A.Z)
	Antibodies from Abcam (H2A.Z, Htz1, Histone H2A.Z), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for H2AFZ

Assays for H2AFZ:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P0C0S5

ProtoNet protein and cluster: P0C0S5

UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5

Similarity: Belongs to the histone H2A family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (H2AFZ)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002106

Applied Biosystems Silencer® siRNAs for H2AFZ

Sigma-Aldrich siRNA for H2AFZ

Sigma-Aldrich shRNA for H2AFZ

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002106
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002106
untagged cDNA clone in CMV expression vector: NM_002106

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002106

UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5

Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular

machineries which require DNA as a template. Histones thereby play a central role in transcription

regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated

via a complex set of post-translational modifications of histones, also called histone code, and

nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be

required for chromosome segregation during cell division

Genatlas biochemistry entry for H2AFZ:

histone family 2,replacement subtype,replication independent protein,species H2A.Z

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for H2afz):

embryogenesis

lethality-prenatal/perinatal

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/16 Interacting proteins for H2AFZ (ENSP00000296417³ P0C0S5²) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RYR1	P21817²	MINT-19797
HIST2H2BE	ENSP00000336417³	STRING (score=.976)
SRCAP	ENSP00000343042³	STRING (score=.957)
TP53	ENSP00000269305³	STRING (score=.886)
KAT5	ENSP00000340330³	STRING (score=.873)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for H2AFZ

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (H2AFZ)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002106

Sigma-Aldrich siRNA for H2AFZ

Sigma-Aldrich shRNA for H2AFZ

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002106

REFSEQ mRNAs for H2AFZ gene:

NM_002106.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002106

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002106
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002106
                                 untagged cDNA clone in CMV expression vector: NM_002106

Additional cDNA sequence:

AK056803.1 AK315413.1 AY597416.1 BC018002.1 BC020936.1 BC103743.1 CR457415.1 CR599577.1

CR611014.1 CR616797.1 D28450.1 M37583.1 X52317.1

24/47 DOTS entries (see all 47 ):

DT.91773756 DT.91773760 DT.91950441 DT.100888814 DT.100888827 DT.100888815 DT.97864672 DT.95089355

DT.91833674 DT.100888829 DT.92324837 DT.92046197 DT.100888818 DT.97800998 DT.121270587 DT.121270648

DT.91773723 DT.121270595 DT.92022017 DT.121270580 DT.100888840 DT.100888841 DT.95089420 DT.100888823

24/1347 AceView cDNA sequences (see all 1347 ):

AI026759 BM769870 AA417367 CA416434 AV718312 AI857890 CR611014 AA782769

BC018002 BM555833 BI087312 BE268132 CB241081 BG575431 BU191893 AV716717

BQ016077 AA361145 BE294435 AV726165 CA447104 BQ218981 AI085737 D28450

highest scoring ESTs for H2AFZ:

M37583 AA013459 AA018132 AA021359 AA021640 AA033802 AA054092 AA082502 AA089996 AA095493

Unigene Cluster for H2AFZ:

H2A histone family, member Z

Hs.119192 [show with all ESTs]

Unigene Representative Sequence: AK056803

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for H2AFZ (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:															-		-
SP2:											-				-		-
SP3:															-
SP4:
SP5:															-		-		-

About this scheme

ECgene alternative splicing isoforms for H2AFZ

1 Ensembl transcript including schematic representation:

ENST00000296417

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

H2AFZ expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for H2AFZ

¹ / ² / ³

5 probe-sets matching H2AFZ gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39337_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M37583	1.00	1.00	1.00	1
213911_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	BF718636	0.40	1.00	0.76	1
200853_at²^{, 3}	U133-A	4	1.00	0.70	--	--	NM_002106	0.60	1.00	0.82	1
213911_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
200853_at²	U133Plus2	4	1.00	0.70	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACGTGTGGG

SOURCE GeneReport for Unigene cluster: Hs.119192
Expression variation in blood from EXPOLDB for H2AFZ

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for H2AFZ gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC478493¹	--	histone H2AF	97.14(n) 100(a)	478493 XM_535671.2 XP_535671.1
chimpanzee (Pan troglodytes)	LOC461400¹	--	hypothetical LOC461400	99.48(n) 100(a)	461400 XM_517363.2 XP_517363.2
cow (Bos taurus)	H2AFZ¹	--	H2A histone family, member Z	97.14(n) 100(a)	287016 NM_174809.2 NP_777234.1
rat (Rattus norvegicus)	H2afz¹	--	H2A histone family, member Z	94.27(n) 100(a)	58940 NM_022674.1 NP_073165.1
mouse (Mus musculus)	H2afz^{1, 5}	3⁵	H2A histone family, member Z^{1, 5}	94.79(n)¹ 100(a)¹	51788¹ NM_016750.2¹ NP_058030.1¹ AA408050⁵ AA409072⁵ (see all 34)

About this table Species with no ortholog for H2AFZ

ENSEMBL Gene Tree for H2AFZ

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for H2AFZ gene

H2AFY2² H2AFV² H2AFY²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/11 NCBI SNPs in H2AFZ are shown (see all 11 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 23)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11554386^1,2	H	101089066(-)	`TTACCC/ACTCGT`	1	T/P	mis¹ ese³		4		EU EA WA	404
	rs2276939^1,2	C,F,H	101089398(+)	`CCTCTT/GGCCGC`	1	--	int¹ trp³		5		EA EU WA	1898
--	rs11554383^1,2	--	101089508(-)	`ACGTGC/TGGGCG`	1	V/A	mis¹		0	--	--	--	--
	rs11554394^1,2	--	101089078(-)	`AGGTAA/GAGCGT`	1	K/E	mis¹		0	--	--	--	--
	rs11554384^1,2	--	101089913(-)	`TGGCGC/GTAAGG`	1	G/A	mis¹		0	--	--	--	--
	rs11554385^1,2	--	101089547(-)	`TATTCA/TTCGAC`	1	H/L	mis¹		0	--	--	--	--
	rs11554389^1,2	--	101089867(-)	`GTTTCA/CCGCTC`	1	S/S	syn¹		0	--	--	--	--
--	rs11554381^1,2	--	101089504(-)	`GTGGGC/GGCGAC`	1	G/G	syn¹ ese³		0	--	--	--	--
--	rs61203457^1,2	--	101089205(+)	`GCAGAC/TCTACC`	1	--	int¹		0	--	--	--	--
--	rs62306065^1,2	--	101090155(+)	`GCCACA/CCAACC`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for H2AFZ (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 142763

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/49 PubMed articles for H2AFZ gene (see all 49 ):

The human histone H2A.Z gene. Sequence and regulation. (PubMed id 1697587)^{2, 3, 4} Hatch C.L. and Bonner W.M. (1990)
Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z. (PubMed id 15878876)^{1, 3, 4} Farris S.D....Krumm A. (2005)
Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)^{1, 3, 4} Bonenfant D.... van Oostrum J. (2006)
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)^{3, 4} Kim S.C.... Zhao Y. (2006)
Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)^{3, 4} Beck H.C.... Jensen O.N. (2006)
Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PubMed id 16457589)^{3, 4} Boyne M.T. II... Kelleher N.L. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Histone ubiquitination: a tagging tail unfolds? (PubMed id 11835281)^{3, 4} Jason L.J.M.... Ausio J. (2002)
Crystal structure of a nucleosome core particle containing the variant histone H2A.Z. (PubMed id 11101893)^{3, 4} Suto R.K.... Luger K. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3015	HGNC: 4741	AceView: H2AFZ	Ensembl:ENSG00000164032	euGenes: HUgn3015
ECgene: H2AFZ	H-InvDB: H2AFZ

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for H2AFZ	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for H2AFZ
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for H2AFZ:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for H2AFZ-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for H2AFZ		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for H2AFZ		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (H2AFZ)
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	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for H2AFZ (Histone H2A.Z)

	Recombinant Proteins (H2A.Z, Htz1, Histone H2A.Z)
	Antibodies (H2A.Z, Htz1, Histone H2A.Z)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for H2AFZ

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for H2AFZ

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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H2AFZ Gene at Home site.
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H2AFZ Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for H2AFZ

Summaries
for H2AFZ

Genomic Location
for H2AFZ

Proteins
for H2AFZ

Protein Domains/
Families
for H2AFZ

Gene Function
for H2AFZ

Pathways & Interactions
for H2AFZ

Drugs & Compounds
for H2AFZ

Transcripts
for H2AFZ

Expression
for H2AFZ

Orthologs
for H2AFZ

Paralogs
for H2AFZ

SNPs/Variants
for H2AFZ

Disorders & Mutations
for H2AFZ

Medical News
for H2AFZ

Publications
for H2AFZ

Search for H2AFZ

Genome Databases showing H2AFZ

Other Databases showing H2AFZ

Specialized Databases showing H2AFZ

Licensable Technologies
for H2AFZ

Services
for H2AFZ

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

H2AFZ Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor H2AFZ

Summariesfor H2AFZ

Genomic Locationfor H2AFZ

Proteinsfor H2AFZ

Protein Domains/Familiesfor H2AFZ

Gene Functionfor H2AFZ

Pathways & Interactionsfor H2AFZ

Drugs & Compoundsfor H2AFZ

Transcriptsfor H2AFZ

Expression for H2AFZ

Orthologsfor H2AFZ

Paralogsfor H2AFZ

SNPs/Variantsfor H2AFZ

Disorders & Mutationsfor H2AFZ

Medical Newsfor H2AFZ

Publicationsfor H2AFZ

Search for H2AFZ

Genome Databases showing H2AFZ

Other Databases showing H2AFZ

Specialized Databases showing H2AFZ

Licensable Technologiesfor H2AFZ

Servicesfor H2AFZ

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for H2AFZ

Summaries
for H2AFZ

Genomic Location
for H2AFZ

Proteins
for H2AFZ

Protein Domains/
Families
for H2AFZ

Gene Function
for H2AFZ

Pathways & Interactions
for H2AFZ

Drugs & Compounds
for H2AFZ

Transcripts
for H2AFZ

Expression
for H2AFZ

Orthologs
for H2AFZ

Paralogs
for H2AFZ

SNPs/Variants
for H2AFZ

Disorders & Mutations
for H2AFZ

Medical News
for H2AFZ

Publications
for H2AFZ

Licensable Technologies
for H2AFZ

Services
for H2AFZ