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Aliases for H2AFZ Gene

Subcategory (RNA class) for H2AFZ Gene

lncRNA

Aliases for H2AFZ Gene

  • H2A Histone Family, Member Z 2 3
  • H2AZ 3 4 6
  • H2A/Z 3 4
  • Histone H2A.Z 3
  • H2AZ Histone 3
  • H2A.Z-1 3
  • H2A.Z 3

External Ids for H2AFZ Gene

ORGUL Members for H2AFZ Gene

Previous HGNC Symbols for H2AFZ Gene

  • H2AZ

Previous GeneCards Identifiers for H2AFZ Gene

  • GC04M101116
  • GC04M101261
  • GC04M101327
  • GC04M101226
  • GC04M100869
  • GC04M096607

Summaries for H2AFZ Gene

Entrez Gene Summary for H2AFZ Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]

GeneCards Summary for H2AFZ Gene

H2AFZ (H2A Histone Family, Member Z) is a Protein Coding gene, and is affiliated with the lncRNA class. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is H2AFV.

UniProtKB/Swiss-Prot for H2AFZ Gene

  • Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Gene Wiki entry for H2AFZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H2AFZ Gene

Genomics for H2AFZ Gene

Regulatory Elements for H2AFZ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for H2AFZ Gene

Start:
99,948,085 bp from pter
End:
99,950,388 bp from pter
Size:
2,304 bases
Orientation:
Minus strand

Genomic View for H2AFZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for H2AFZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H2AFZ Gene

Proteins for H2AFZ Gene

  • Protein details for H2AFZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C0S5-H2AZ_HUMAN
    Recommended name:
    Histone H2A.Z
    Protein Accession:
    P0C0S5
    Secondary Accessions:
    • B2RD56
    • P17317
    • Q6I9U0

    Protein attributes for H2AFZ Gene

    Size:
    128 amino acids
    Molecular mass:
    13553 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms a heterodimer with H2B. H2AFZ interacts with INCENP (By similarity). Interacts (via M6 cassette) with ANP32E; leading to removal of H2A.Z/H2AFZ from the nucleosome.

    Three dimensional structures from OCA and Proteopedia for H2AFZ Gene

neXtProt entry for H2AFZ Gene

Proteomics data for H2AFZ Gene at MOPED

Post-translational modifications for H2AFZ Gene

  • Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity).
  • Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression
  • Not phosphorylated.
  • Ubiquitination at Lys116, Lys121, and Lys122
  • Modification sites at PhosphoSitePlus

Other Protein References for H2AFZ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for H2AFZ (H2AZ)

No data available for DME Specific Peptides for H2AFZ Gene

Domains for H2AFZ Gene

Gene Families for H2AFZ Gene

HGNC:
  • RIH :Histones / Replication-independent

Protein Domains for H2AFZ Gene

Suggested Antigen Peptide Sequences for H2AFZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C0S5

UniProtKB/Swiss-Prot:

H2AZ_HUMAN :
  • P0C0S5
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with H2AFZ: view

Function for H2AFZ Gene

Molecular function for H2AFZ Gene

GENATLAS Biochemistry: histone family 2,replacement subtype,replication independent protein,species H2A.Z
UniProtKB/Swiss-Prot Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Gene Ontology (GO) - Molecular Function for H2AFZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19834540
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA 19633671
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 19633671
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 20473270
genes like me logo Genes that share ontologies with H2AFZ: view

Phenotypes for H2AFZ Gene

genes like me logo Genes that share phenotypes with H2AFZ: view

Animal Models for H2AFZ Gene

MGI Knock Outs for H2AFZ:

Animal Model Products

miRNA for H2AFZ Gene

miRTarBase miRNAs that target H2AFZ

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for H2AFZ Gene

Localization for H2AFZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for H2AFZ Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for H2AFZ Gene COMPARTMENTS Subcellular localization image for H2AFZ gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for H2AFZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0001740 NOT Barr body IDA 11331621
GO:0005634 nucleus IDA 11331621
GO:0005719 nuclear euchromatin IDA 19834540
GO:0005720 nuclear heterochromatin IDA 19834540
genes like me logo Genes that share ontologies with H2AFZ: view

Pathways for H2AFZ Gene

genes like me logo Genes that share pathways with H2AFZ: view

Pathways by source for H2AFZ Gene

1 Cell Signaling Technology pathway for H2AFZ Gene
26 Reactome pathways for H2AFZ Gene
2 KEGG pathways for H2AFZ Gene
1 GeneGo (Thomson Reuters) pathway for H2AFZ Gene

Gene Ontology (GO) - Biological Process for H2AFZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 19834540
GO:0071392 cellular response to estradiol stimulus IMP 23637611
genes like me logo Genes that share ontologies with H2AFZ: view

Transcripts for H2AFZ Gene

Unigene Clusters for H2AFZ Gene

H2A histone family, member Z:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H2AFZ

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for H2AFZ Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5: - - -
SP6:

Relevant External Links for H2AFZ Gene

GeneLoc Exon Structure for
H2AFZ
ECgene alternative splicing isoforms for
H2AFZ

Expression for H2AFZ Gene

mRNA expression in normal human tissues for H2AFZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for H2AFZ Gene

SOURCE GeneReport for Unigene cluster for H2AFZ Gene Hs.119192

genes like me logo Genes that share expressions with H2AFZ: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for H2AFZ Gene

Orthologs for H2AFZ Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for H2AFZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H2AFZ 35
  • 99.48 (n)
  • 100 (a)
H2AFZ 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia H2AFZ 35
  • 97.14 (n)
  • 100 (a)
H2AFZ 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
H2AFZ 35
  • 97.4 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia H2afz 35
  • 94.79 (n)
  • 100 (a)
H2afz 16
H2afz 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia H2AFZ 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia H2afz 35
  • 94.27 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves H2AFZ 35
  • 84.37 (n)
  • 99.22 (a)
H2AFZ 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia H2AFZ 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53404 35
tropical clawed frog
(Silurana tropicalis)
Amphibia h2afz 35
  • 76.3 (n)
  • 89.84 (a)
Str.6600 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8307 35
zebrafish
(Danio rerio)
Actinopterygii h2afvb 35
  • 76.3 (n)
  • 99.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta His2Av 36
  • 85 (a)
OneToMany
His2Av 37
  • 100 (a)
worm
(Caenorhabditis elegans)
Secernentea htz-1 36
  • 74 (a)
OneToMany
R08C7.3 37
  • 91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HTZ1 36
  • 61 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons HTA9 35
  • 64.8 (n)
  • 77.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7971 36
  • 83 (a)
OneToMany
Species with no ortholog for H2AFZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for H2AFZ Gene

ENSEMBL:
Gene Tree for H2AFZ (if available)
TreeFam:
Gene Tree for H2AFZ (if available)

Paralogs for H2AFZ Gene

Paralogs for H2AFZ Gene

genes like me logo Genes that share paralogs with H2AFZ: view

Variants for H2AFZ Gene

Sequence variations from dbSNP and Humsavar for H2AFZ Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3756087 -- 99,950,774(+) CCCGG(A/G)CACCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for H2AFZ Gene

Variant ID Type Subtype PubMed ID
nsv879661 CNV Loss 21882294
nsv879662 CNV Loss 21882294
nsv879663 CNV Loss 21882294
nsv822668 CNV Gain 20364138
esv25894 CNV Loss 19812545

Relevant External Links for H2AFZ Gene

HapMap Linkage Disequilibrium report
H2AFZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H2AFZ Gene

Disorders for H2AFZ Gene

No disorders were found for H2AFZ Gene.

No data available for UniProtKB/Swiss-Prot for H2AFZ Gene

Publications for H2AFZ Gene

  1. Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z. (PMID: 15878876) Farris S.D. … Krumm A. (J. Biol. Chem. 2005) 3 4 23
  2. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PMID: 16319397) Bonenfant D. … van Oostrum J. (Mol. Cell. Proteomics 2006) 3 4 23
  3. The human histone H2A.Z gene. Sequence and regulation. (PMID: 1697587) Hatch C.L. … Bonner W.M. (J. Biol. Chem. 1990) 2 3 4
  4. Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species. (PMID: 3344202) Hatch C.L. … Bonner W.M. (Nucleic Acids Res. 1988) 3 4
  5. Analysis of human histone H2AZ deposition in vivo argues against its direct role in epigenetic templating mechanisms. (PMID: 16809769) Viens A. … Ogryzko V. (Mol. Cell. Biol. 2006) 3 23

Products for H2AFZ Gene

Sources for H2AFZ Gene

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