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H2AFZ Gene

protein-coding   GIFtS: 62
GCID: GC04M100869

H2A Histone Family, Member Z


(Previous symbol: H2AZ)
  Search for H2AFZ
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4.2

Aliases
H2A Histone Family, Member Z1 2     H2A.z2
H2AZ1 2 3 5     H2AZ Histone2
H2A/z2 3     Histone H2A.Z2
H2A.Z-12     

External Ids:    HGNC: 47411   Entrez Gene: 30152   Ensembl: ENSG000001640327   OMIM: 1427635   UniProtKB: P0C0S53   
ORGUL members:    fRNAdb10:FR246045 FR049681      
H-InvDB12:HIT000101279    
NCBI13:D28450    
NONCODE14:n342613    
RNAdb15:HIV1202 EVF14361    

Export aliases for H2AFZ gene to outside databases

Previous GC identifers: GC04M101116 GC04M101261 GC04M101327 GC04M101226 GC04M096607


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for H2AFZ Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from
other members of the family. Studies in mice have shown that this particular histone is required for embryonic
development and indicate that lack of functional histone H2A leads to embryonic lethality. (provided by RefSeq,
Jul 2008)

GeneCards Summary for H2AFZ Gene:
H2AFZ (H2A histone family, member Z) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is H2AFV.

UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and
compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a
template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and
chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of
histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive
heterochromatin. May be required for chromosome segregation during cell division

Gene Wiki entry for H2AFZ Gene

fRNAdb sequence ontologies for H2AFZ - the ORGUL cluster for this gene includes several descriptions:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for H2AFZ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the H2AFZ gene promoter:
         HOXA9B   HOXA9   HTF   USF-1:USF-2   Nkx2-5   CREB   USF-1   deltaCREB   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidH2AFZ promoter sequence
   Search Chromatin IP Primers for H2AFZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat H2AFZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23

H2AFZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H2AFZ gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100869:  view genomic region     (about GC identifiers)

Start:
100,869,243 bp from pter      End:
100,871,545 bp from pter
Size:
2,303 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for H2AFZ

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5 (See protein sequence)
Recommended Name: Histone H2A.Z  
Size: 128 amino acids; 13553 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its
variant H2AFZ forms a heterodimer with H2B. H2AFZ interacts with INCENP (By similarity). Interacts (via M6
cassette) with ANP32E; leading to removal of H2A.Z/H2AFZ from the nucleosome
Mass spectrometry: Mass=13413.4; Method=Electrospray; Range=2-128; Note=Monoisotopic, not modified;
Source=PubMed:16457589;
3 PDB 3D structures from and Proteopedia for H2AFZ:
1F66 (3D)        3WA9 (3D)        4CAY (3D)    
Secondary accessions: B2RD56 P17317 Q6I9U0

Explore the universe of human proteins at neXtProt for H2AFZ: NX_P0C0S5

Explore proteomics data for H2AFZ at MOPED

Post-translational modifications: 

  • Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression1
  • Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity)1
  • Not phosphorylated (By similarity)1
  • Ubiquitination2 at Lys116, Lys121, Lys122
  • Modification sites at PhosphoSitePlus

  • See H2AFZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002097.1  
    ENSEMBL proteins: 
     ENSP00000296417  
    Reactome Protein details: P0C0S5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RIH: Histones / Replication-independent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P0C0S5

    ProtoNet protein and cluster: P0C0S5

    UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5
    Similarity: Belongs to the histone H2A family


    Find genes that share domains with H2AFZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2AZ_HUMAN, P0C0S5
    Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and
    compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a
    template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and
    chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of
    histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive
    heterochromatin. May be required for chromosome segregation during cell division

         Genatlas biochemistry entry for H2AFZ:
    histone family 2,replacement subtype,replication independent protein,species H2A.Z

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with H2AFZ           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for H2afz):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with H2AFZ           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out H2afztm1Ily for H2AFZ

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for H2AFZ
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for H2AFZ

    miRNA
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    miRTarBase miRNAs that target H2AFZ:
    hsa-mir-99b-5p (MIRT044176), hsa-mir-148b-3p (MIRT043584), hsa-mir-197-3p (MIRT048062)

    Block miRNA regulation of human, mouse, rat H2AFZ using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate H2AFZ:
    hsa-miR-4324 hsa-miR-499-5p hsa-miR-212 hsa-miR-548aa hsa-miR-132 hsa-miR-103a-2* hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidH2AFZ 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat H2AFZ

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    Sino Biological Human cDNA Clone for H2AFZ
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H2AFZ

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2AFZ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H2AZ_HUMAN, P0C0S5: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0001740NOT Barr body IDA11331621
    GO:0005634nucleus IDA11331621

    Find genes that share ontologies with H2AFZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for H2AFZ About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    RNA Polymerase I Chain Elongation0.78
    Amyloids0.68
    RNA Polymerase I Promoter Clearance0.78
    Mitotic Prophase0.56
    RNA Polymerase I Promoter Opening0.78
    Systemic lupus erythematosus0.40
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74


    Find genes that share SuperPaths with H2AFZ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for H2AFZ
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for H2AFZ
        Signal transduction Activin A signaling regulation

    3 BioSystems Pathways for H2AFZ
        Proteasome Degradation
    RB in Cancer
    C-MYB transcription factor network


    Selected Reactome Pathways for H2AFZ (see all 15)
        NoRC negatively regulates rRNA expression
    Deposition of new CENPA-containing nucleosomes at the centromere
    Meiotic recombination
    formation of the beta-catenin:TCF transactivating complex
    Oxidative Stress Induced Senescence


    2 Kegg Pathways  (Kegg details for H2AFZ):
        Alcoholism
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for H2AFZ
    Interactions:

        Search GeneGlobe Interaction Network for H2AFZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for H2AFZ (P0C0S51, 2, 3 ENSP000002964174) via UniProtKB, MINT, STRING, and/or I2D (see all 622)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=5 STRING: ENSP00000352980
    HIST1H4DP628053, ENSP000003432824I2D: score=5 STRING: ENSP00000343282
    HIST1H4EP628053, ENSP000003536244I2D: score=5 STRING: ENSP00000353624
    HIST1H4HP628053, ENSP000002893524I2D: score=5 STRING: ENSP00000289352
    HIST1H4IP628053, ENSP000003463164I2D: score=5 STRING: ENSP00000346316
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    Find genes that share ontologies with H2AFZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for H2AFZ (H2AZ)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    2 fRNAdb Secondary structures:


    REFSEQ mRNAs for H2AFZ gene: 
    NM_002106.3  

    Unigene Cluster for H2AFZ:

    H2A histone family, member Z
    Hs.119192  [show with all ESTs]
    Unigene Representative Sequence: AK056803
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511348(uc003hvn.1 uc003hvo.1) ENST00000511203 ENST00000296417
    ENST00000511319 ENST00000529158 ENST00000527366
    miRNA
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    hsa-miR-4324 hsa-miR-499-5p hsa-miR-212 hsa-miR-548aa hsa-miR-132 hsa-miR-103a-2* hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidH2AFZ 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: H2AFZ (NM_002106)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat H2AFZ
      QuantiFast Probe-based Assays in human, mouse, rat H2AFZ

    Additional mRNA sequence: 

    AK056803.1 AK315413.1 AY597416.1 BC018002.1 BC020936.1 BC103743.1 CR457415.1 D28450.1 
    M37583.1 X52317.1 

    Selected DOTS entries (see all 47):

    DT.91773756  DT.91773760  DT.91950441  DT.100888814  DT.100888827  DT.100888815  DT.97864672  DT.95089355 
    DT.91833674  DT.100888829  DT.92324837  DT.92046197  DT.100888818  DT.97800998  DT.121270587  DT.121270648 
    DT.121270595  DT.92022017  DT.121270580  DT.91773723  DT.100888840  DT.100888841  DT.95089420  DT.100888823 

    Selected AceView cDNA sequences (see all 1347):

    BQ428213 BQ016077 BQ029980 AI124799 W73715 AV713925 CA394054 CD672072 
    BP367714 AI148346 AV712405 CA446826 CB160226 BI858147 BU153176 CA307111 
    AA417367 CR611014 AV716717 BU159742 AV715420 D56720 CB124772 BM747184 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for H2AFZ (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                                            -     -                                             
    SP2:                                -           -     -                                             
    SP3:                                            -                                                   
    SP4:                                                                                                
    SP5:                                            -     -     -                                       


    ECgene alternative splicing isoforms for H2AFZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    H2AFZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGTGTGGG
    H2AFZ Expression
    About this image


    H2AFZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    H2AFZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    H2AFZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.119192
        Custom PCR Arrays for H2AFZ
    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for H2AFZ gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2afz1 , 5 H2A histone family, member Z1, 5 94.79(n)1
    100(a)1
      3 (63.94 cM)5
    517881  NM_016750.21  NP_058030.11 
     1378644875 
    chicken
    (Gallus gallus)
    Aves H2AFZ1 H2A histone family, member Z 84.37(n)
    99.22(a)
      426361  NM_001031374.1  NP_001026545.1 
    lizard
    (Anolis carolinensis)
    Reptilia H2AFZ6
    H2A histone family, member Z
    98(a)
    1 ↔ 1
    GL343323.1(1018331-1025703)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC534042 hypothetical protein MGC53404 81.91(n)    X98536.1 
    zebrafish
    (Danio rerio)
    Actinopterygii h2afvb1 H2A histone family, member Vb 76.3(n)
    99.22(a)
      403077  NM_001043323.1  NP_001036788.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His2Av3 chromatin assembly/disassembly DNA
    binding
    100(a)   97D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea R08C7.33 histone H2A variant 91(a)   IV(4446274-4447034)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HTZ16
    Histone variant H2AZ, exchanged for histone H2A in...
    61(a)
    1 → many
    XV(303579-303983) YOL012C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HTA91 HTA9 64.8(n)
    77.6(a)
      841707  NM_104152.3  NP_175683.1 


    ENSEMBL Gene Tree for H2AFZ (if available)
    TreeFam Gene Tree for H2AFZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for H2AFZ gene
    H2AFV2  
    Selected SIMAP similar genes for H2AFZ using alignment to 1 protein entry:     H2AZ_HUMAN(see all similar genes):
    H2AFV    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG
    HIST1H2AH    HIST1H2AI    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM
    HIST2H2AA3    HIST2H2AA4    HIST2H2AC    HIST3H2A    HIST1H2AA    HIST2H2AB

    Find genes that share paralogs with H2AFZ           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for H2AFZ (see all 7)
    PGOHUM00000238850 PGOHUM00000242349 PGOHUM00000248478 PGOHUM00000239090 PGOHUM00000246310


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for H2AFZ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879663CNV Loss21882294
    esv25894CNV Loss19812545
    nsv879661CNV Loss21882294
    nsv879662CNV Loss21882294
    nsv822668CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142763OMIM information: 601519 603663 605480 609456    

    Find genes that share disorders with H2AFZ           About GenesLikeMe


    Export disorders for H2AFZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for H2AFZ gene, integrated from 10 sources (see all 101):
    (articles sorted by number of sources associating them with H2AFZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human histone H2A.Z gene. Sequence and regulation. (PubMed id 1697587)1, 2, 3 Hatch C.L. and Bonner W.M. (J. Biol. Chem. 1990)
    2. Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z. (PubMed id 15878876)1, 2, 9 Farris S.D....Krumm A. (J. Biol. Chem. 2005)
    3. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)1, 2, 9 Bonenfant D.... van Oostrum J. (Mol. Cell. Proteomics 2006)
    4. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (Mol. Cell. Proteomics 2006)
    5. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PubMed id 16457589)1, 2 Boyne M.T. II... Kelleher N.L. (J. Proteome Res. 2006)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Histone ubiquitination: a tagging tail unfolds? (PubMed id 11835281)1, 2 Jason L.J.M.... Ausio J. (Bioessays 2002)
    10. Crystal structure of a nucleosome core particle containing the variant histone H2A.Z. (PubMed id 11101893)1, 2 Suto R.K.... Luger K. (Nat. Struct. Biol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3015 HGNC: 4741 AceView: H2AFZ Ensembl:ENSG00000164032 euGenes: HUgn3015
    ECgene: H2AFZ Kegg: 3015 H-InvDB: H2AFZ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for H2AFZ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for H2AFZ Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for H2AFZ gene:
    Search GeneIP for patents involving H2AFZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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