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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

H2AFZ Gene

protein-coding   GIFtS: 63
GCID: GC04M100869

H2A histone family, member Z


(Previous symbol: H2AZ)
 Explore 11 diseases affiliated with
H2AFZ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for H2AFZ    

Aliases
for H2AFZ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
H2A Histone Family, Member Z1 2     H2A.Z1
H2AZ1 2 3 5     H2AZ Histone2
H2A/Z1     Histone H2A.Z2
H2A.Z1     

External Ids:    HGNC: 47411   Entrez Gene: 30152   Ensembl: ENSG000001640327   OMIM: 1427635   UniProtKB: P0C0S53   
ORGUL members:    fRNAdb10:FR246045      
H-InvDB:HIT000101279    
NCBI:D28450    
NONCODE:n342613    
RNAdb:HIV1202    

Export aliases for H2AFZ gene to outside databases

Previous GC identifers: GC04M101116 GC04M101261 GC04M101327 GC04M101226 GC04M096607


Summaries
for H2AFZ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for H2AFZ:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of
each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of
the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate
that lack of functional histone H2A leads to embryonic lethality. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact
DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones
thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA
accessibility is regulated via a complex set of post-translational modifications of histones, also called histone
code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for
chromosome segregation during cell division

Gene Wiki entry for H2AFZ

fRNAdb sequence ontology for H2AFZ:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for H2AFZ

Genomic Views
for H2AFZ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the H2AFZ gene promoter:
         HOXA9B   HOXA9   HTF   USF-1:USF-2   Nkx2-5   CREB   USF-1   deltaCREB   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: H2AFZ promoter sequence
   Search SABiosciences Chromatin IP Primers for H2AFZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H2AFZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23

H2AFZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H2AFZ gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M100869:  view genomic region     (about GC identifiers)

Start:
 100,869,243 bp from pter      End:
 100,871,545 bp from pter
Size:
 2,303 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n342613
  • FR0246045
100869242 100870377 100871512 chr4

Proteins
for H2AFZ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5 (See protein sequence)
Recommended Name: Histone H2A.Z  
Size: 128 amino acids; 13553 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant
H2AFZ forms a heterodimer with H2B. H2AFZ interacts with INCENP (By similarity)
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=13413.4; Method=Electrospray; Range=2-128; Note=Monoisotopic, not modified;
Source=PubMed:16457589;
1 PDB 3D structure from and Proteopedia for H2AFZ:
1F66 (3D)    
Secondary accessions: B2RD56 P17317 Q6I9U0

Explore the universe of human proteins at neXtProt for H2AFZ: NX_P0C0S5

Post-translational modifications:

  • Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression1
  • Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity)1
  • Not phosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P0C0S5

    • H2AFZ Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002097.1  
    ENSEMBL proteins: 
     ENSP00000296417  
    Reactome Protein details: P0C0S5
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant H2AFZ Protein
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    Novus Biologicals H2AFZ Protein
    Novus Biologicals H2AFZ Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for H2AFZ

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0001740NOT Barr body IDA11331621
    GO:0005634nucleus IDA11331621


    H2AFZ for ontologies           About GeneDecksing



    H2AFZ Antibody Products: 
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    Novus Biologicals H2AFZ Antibody
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    ThermoFisher Antibody for H2AFZ

    Assay Products for H2AFZ: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for H2AFZ

    Protein Domains /
    Families
    for H2AFZ gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    H2AFZ for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P0C0S5

    ProtoNet protein and cluster: P0C0S5

    UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5
    Similarity: Belongs to the histone H2A family


    Function
    for H2AFZ gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H2AZ_HUMAN, P0C0S5
    Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact
    DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones
    thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA
    accessibility is regulated via a complex set of post-translational modifications of histones, also called histone
    code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for
    chromosome segregation during cell division

         Genatlas biochemistry entry for H2AFZ:
    histone family 2,replacement subtype,replication independent protein,species H2A.Z

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H2AFZ
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate H2AFZ:
    hsa-miR-4324 hsa-miR-499-5p hsa-miR-212 hsa-miR-548aa hsa-miR-132 hsa-miR-103a-2* hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmid: H2AFZ 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for H2AFZ

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2AFZ

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--


    H2AFZ for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out H2afztm1Ily for H2AFZ
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for H2afz):
     embryogenesis  mortality/aging 

    H2AFZ for phenotypes           About GeneDecksing


    Pathways & Interactions
    for H2AFZ gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiotic Synapsis1.00
    		Packaging Of Telomere Ends0.54
    		Telomere clustering at the nuclear membrane0.82
    		Telomere Maintenance0.38
    		Meiosis0.70
    		Meiotic Recombination0.32
    		Chromosome Maintenance0.56
    2RSF Complex Binds the Centromere.
    		RSF Complex Binds the Centromere.1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere1.00
    		Nucleosome assembly1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere.0.96
    3Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    4Chromatin Regulation / Acetylation
    		Chromatin Regulation / Acetylation1.00
    5Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for H2AFZ
        Histone modification
    Signal transduction Activin A signaling regulation


    1 Cell Signaling Technology (CST) Pathway for H2AFZ
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for H2AFZ
        Signal transduction Activin A signaling regulation

    2 BioSystems Pathways for H2AFZ 
        Proteasome Degradation
    C-MYB transcription factor network

    5/14        Reactome Pathways for H2AFZ (see all 14)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Deposition of New CENPA-containing Nucleosomes at the Centromere


    1         Kegg Pathway  (Kegg details for H2AFZ):
        Systemic lupus erythematosus


    H2AFZ for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H2AFZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/252 Interacting proteins for H2AFZ (P0C0S52, 3 ENSP000002964174) via UniProtKB, MINT, STRING, and/or I2D (see all 252)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628053, ENSP000003665814I2D: score=5 STRING: ENSP00000366581
    HIST1H4DP628053, ENSP000003432824I2D: score=5 STRING: ENSP00000343282
    HIST1H4EP628053, ENSP000003536244I2D: score=5 STRING: ENSP00000353624
    HIST1H4HP628053, ENSP000002893524I2D: score=5 STRING: ENSP00000289352
    HIST1H4IP628053, ENSP000003463164I2D: score=5 STRING: ENSP00000346316
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--


    H2AFZ for ontologies           About GeneDecksing



    Drugs & Compounds
    for H2AFZ gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for H2AFZ
    Search CenterWatch for drugs/clinical trials and news about H2AFZ / H2AZ 

    Transcripts
    for H2AFZ gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    		 1 fRNAdb Secondary structure:


    REFSEQ mRNAs for H2AFZ gene: 
    NM_002106.3  

    Unigene Cluster for H2AFZ:

    H2A histone family, member Z
    Hs.119192  [show with all ESTs]
    Unigene Representative Sequence: AK056803
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511348(uc003hvn.1 uc003hvo.1) ENST00000511203 ENST00000296417
    ENST00000511319 ENST00000529158 ENST00000527366

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate H2AFZ:
    hsa-miR-4324 hsa-miR-499-5p hsa-miR-212 hsa-miR-548aa hsa-miR-132 hsa-miR-103a-2* hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmid: H2AFZ 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for H2AFZ (see all 7)
    OriGene shRNA RFP: H2AFZ
    OriGene siRNA: H2AFZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H2AFZ
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK056803.1 AK315413.1 AY597416.1 BC018002.1 BC020936.1 BC103743.1 CR457415.1 D28450.1 
    M37583.1 X52317.1 

    24/47 DOTS entries (see all 47):

    DT.91773756  DT.91773760  DT.91950441  DT.100888814  DT.100888827  DT.100888815  DT.97864672  DT.95089355 
    DT.91833674  DT.100888829  DT.92324837  DT.92046197  DT.100888818  DT.97800998  DT.121270587  DT.121270648 
    DT.121270595  DT.92022017  DT.121270580  DT.91773723  DT.100888840  DT.100888841  DT.95089420  DT.100888823 

    24/1347 AceView cDNA sequences (see all 1347):

    CB133371 CB127401 BU689053 BM800101 AA361145 CB110556 BM807308 CA427174 
    BG259909 CA443142 CB122821 AW575423 AI139232 BU176979 CB138561 AV713248 
    AI857890 CA443243 CD722692 BU665173 AW008381 CB241081 AA379697 BM830949 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for H2AFZ (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                                            -     -                                             
    SP2:                                -           -     -                                             
    SP3:                                            -                                                   
    SP4:                                                                                                
    SP5:                                            -     -     -                                       


    ECgene alternative splicing isoforms for H2AFZ

    Expression
    for H2AFZ gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    H2AFZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACGTGTGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    H2AFZ expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See H2AFZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for H2AFZ

    SOURCE GeneReport for Unigene cluster: Hs.119192
        SABiosciences Custom PCR Arrays for H2AFZ
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for H2AFZ gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for H2AFZ gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves H2AFZ1 H2A histone family, member Z 84.37(n)
    99.22(a)    		   426361  NM_001031374.1  NP_001026545.1 
    lizard
    (Anolis carolinensis)    		 Reptilia H2AFZ6
    		 --
    		 98(a)
    		 1 ↔ 1
    		 GL343323.1(1019002-1023532)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC534042 hypothetical protein MGC53404 81.91(n)    X98536.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii h2afvl1 H2A histone family, member V, like 76.3(n)
    99.22(a)    		   403077  NM_001043323.1  NP_001036788.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta His2Av3 chromatin assembly/disassembly DNA binding 100(a)   97D5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea R08C7.33 histone H2A variant 91(a)   IV(4446274-4447034)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HTA91 histone H2A protein 9 65.31(n)
    78.86(a)    		   841707  NM_104152.3  NP_175683.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 Core histone H2A/H2B/H3/H4 domain containing prote...
    Core histone H2A/H2B/H3/H4 domain containing prote...
    (see all 3)    		 75(a)
    75(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 3(30506745-30509561)
    3(3370370-3371406)


    ENSEMBL Gene Tree for H2AFZ (if available)
    TreeFam Gene Tree for H2AFZ (if available) 

    Paralogs
    for H2AFZ gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for H2AFZ gene
    H2AFY22  HIST1H2AA2  H2AFV2  H2AFY2  
    18/26 SIMAP similar genes for H2AFZ using alignment to 1 protein entry:     H2AZ_HUMAN(see all similar genes):
    H2AFV    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG
    HIST1H2AH    HIST1H2AI    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM
    HIST2H2AA3    HIST2H2AA4    HIST2H2AC    HIST3H2A    HIST1H2AA    HIST2H2AB

    H2AFZ for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for H2AFZ (see all 7)
    PGOHUM00000238850 PGOHUM00000242349 PGOHUM00000248478 PGOHUM00000239090 PGOHUM00000246310


    Genomic Variants
    for H2AFZ gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for H2AFZ
         1 Indel: 68776
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H2AFZ
    DNA2.0 Custom Variant and Variant Library Synthesis for H2AFZ

    Disorders / Diseases
    for H2AFZ gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    H2AFZ for disorders           About GeneDecksing

    OMIM gene information: 142763 601519 603663 605480 609456    
    11 diseases for H2AFZ:    About MalaCards
    progressive transformation of germinal centers    systemic lupus erythematosus    lupus erythematosus    chronic lymphocytic leukemia
    eaf    lymphocytic leukemia    pharyngitis    leukemia
    breast cancer    immunodeficiency    malaria


    Export disorders for H2AFZ gene to outside databases

    Publications
    for H2AFZ gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for H2AFZ gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with H2AFZ)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human histone H2A.Z gene. Sequence and regulation. (PubMed id 1697587)1, 2, 3 Hatch C.L. and Bonner W.M. (1990)
    2. Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z. (PubMed id 15878876)1, 2, 9 Farris S.D....Krumm A. (2005)
    3. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)1, 2, 9 Bonenfant D.... van Oostrum J. (2006)
    4. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (2006)
    5. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PubMed id 16457589)1, 2 Boyne M.T. II... Kelleher N.L. (2006)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Histone ubiquitination: a tagging tail unfolds? (PubMed id 11835281)1, 2 Jason L.J.M.... Ausio J. (2002)
    10. Crystal structure of a nucleosome core particle containing the variant histone H2A.Z. (PubMed id 11101893)1, 2 Suto R.K.... Luger K. (2000)

    External Searches for H2AFZ gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing H2AFZ gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3015 HGNC: 4741 AceView: H2AFZ Ensembl:ENSG00000164032 euGenes: HUgn3015
    ECgene: H2AFZ Kegg: 3015 H-InvDB: H2AFZ

    Other Databases showing H2AFZ gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing H2AFZ gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for H2AFZ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for H2AFZ Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for H2AFZ gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for H2AFZ gene:
    Search GeneIP for patents involving H2AFZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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