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Aliases & Descriptions for H2AFY2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MACROH2A2 3 | | OTTHUMP00000019735 2 | | mH2A2 3 | | macroH2A2 1, 2 |
| | | Descriptions |
|---|
| H2A histone family, member Y2 2 | | Histone macroH2A2 3 | | core histone macroH2A2.2 2 |
|
| | Search outside databases for aliases for H2AFY2 genePrevious GC identifers: GC10P070623 GC10P070899 GC10P071704 GC10P071157 |
Summaries for H2AFY2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: H2AW_HUMAN, Q9P0M6Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivationGene Wiki entry for H2AFY2 |
Genomic Location for H2AFY2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the H2AFY2 gene 
Entrez Gene cytogenetic band: 10q22 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.1H2AFY2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P071482:
(about GC identifiers)
Start:
|
71,482,363 bp from pter |
End:
|
71,542,046 bp from pter |
Size:
|
59,684 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_008583.16
| Proteins for H2AFY2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: H2AW_HUMAN, Q9P0M6 (See
protein sequence)Recommended Name: Core histone macro-H2A.2 Size: 372 amino acids; 40058 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers
Subcellular location: Nucleus. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin
Secondary accessions: Q5SQT2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_061119.1
ENSEMBL proteins: ENSP00000362352 ENSP00000378486
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: H2AFY2 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for H2AFY2: Assays for H2AFY2: | Protein
Domains/ Families for H2AFY2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9P0M6
ProtoNet protein and cluster: Q9P0M6 2 Blocks protein families: IPB002119 Histone H2A IPB002589 Protein of unknown function Appr-1
UniProtKB/Swiss-Prot: H2AW_HUMAN, Q9P0M6Similarity: Contains 1 histone H2A domainSimilarity: Contains 1 Macro domain | Gene Function for H2AFY2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018649
Applied Biosystems Silencer® siRNAs for H2AFY2
Sigma-Aldrich siRNA for H2AFY2  Sigma-Aldrich shRNA for H2AFY2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018649                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018649                                  untagged cDNA clone in CMV expression vector: NM_018649 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018649
UniProtKB/Swiss-Prot: H2AW_HUMAN, Q9P0M6Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | About this table | Pathways & Interactions for H2AFY2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for H2AFY2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for H2AFY2
|
Transcripts for H2AFY2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018649
Sigma-Aldrich siRNA for H2AFY2  Sigma-Aldrich shRNA for H2AFY2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018649 REFSEQ mRNAs for H2AFY2 gene: NM_018649.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018649               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018649                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018649                                  untagged cDNA clone in CMV expression vector: NM_018649  Additional cDNA sequence: AF336304.1 AK022475.1 AK022776.1 AK131057.1 AL359572.1 BC016172.2 CR592495.1 CR601217.1 CR613322.1 CR613570.1 CR623698.1 8 DOTS entries: DT.416777 DT.91766758 DT.100714171 DT.102829851 DT.416778 DT.91766762 DT.95312865 DT.106028 24/207 AceView cDNA sequences (see all 207
):BQ428558 BC016172 BG055758 BG913090 BM724974 BU741376 BM670635 BM711131 AA633441 BI767336 AI435068 BE047110 AA402908 BQ648649 BQ231153 AW136167 CN481762 BM682238 CR613570 BE464932 AK131057 CB241177 AA285026 CA390171
highest scoring ESTs for H2AFY2:AI022248 AA285016 AA285026 AA318946 AA565703 AA581324 AA633441 AA678734 AA702525 AA704931 Unigene Cluster for H2AFY2: H2A histone family, member Y2 Hs.499953 [show with all ESTs]Unigene Representative Sequence: AL359572
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000373255
ENST00000395046
|
Expression for H2AFY2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| H2AFY2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for H2AFY2
1 / 2 / 3 3 probe-sets matching H2AFY2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGTTTTCCTC
SOURCE GeneReport for Unigene cluster: Hs.499953
|
Orthologs for H2AFY2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for H2AFY2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for H2AFY2
ENSEMBL Gene Tree for H2AFY2 | Paralogs for H2AFY2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for H2AFY2 gene
- H2AFV2 H2AFZ2 H2AFY2
|
SNPs/Variants for H2AFY2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for H2AFY2 (up to first 250kb)
|
Disorders & Mutations for H2AFY2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for H2AFY2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for H2AFY2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for H2AFY2 gene (see all 11
):- Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. (PubMed id 11331621)1, 2, 3, 4 Chadwick B.P. and Willard H.F. (2001)
- MACROH2A2, a new member of the MARCOH2A core histone family. (PubMed id 11262398)2, 3, 4 Costanzi C. and Pehrson J.R. (2001)
- Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. (PubMed id 15621527)3, 4 Zhang R.... Adams P.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)3, 4 Deloukas P.... Rogers J. (2004)
- Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. (PubMed id 14657027)3 Lusic M....Giacca M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. (PubMed id 11689053)3 Deng L....Kashanchi F. (2001)
- Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. (PubMed id 11080476)3 Deng L.... Kashanchi F. (2000)
|
Search for H2AFY2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing H2AFY2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing H2AFY2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H2AFY2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for H2AFY2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for H2AFY2:

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Incremental update: 13 Oct 2009
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