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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

H2AFY2 Gene

protein-coding   GIFtS: 56
GCID: GC10P071812

H2A Histone Family, Member Y2

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
H2A Histone Family, Member Y21 2     Core Histone MacroH2A2.22
Histone MacroH2A22 3     macroH2A22
mH2A22 3     MACROH2A23
Core Histone Macro-H2A.22     

External Ids:    HGNC: 144531   Entrez Gene: 555062   Ensembl: ENSG000000992847   UniProtKB: Q9P0M63   

Export aliases for H2AFY2 gene to outside databases

Previous GC identifers: GC10P070623 GC10P070899 GC10P071704 GC10P071157 GC10P071482 GC10P065804


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for H2AFY2 Gene: 
H2AFY2 (H2A histone family, member Y2) is a protein-coding gene. Diseases associated with H2AFY2 include systemic lupus erythematosus, and lupus erythematosus, and among its related super-pathways are Systemic lupus erythematosus. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is H2AFB1.

UniProtKB/Swiss-Prot: H2AW_HUMAN, Q9P0M6
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses
transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular
machineries which require DNA as a template. Histones thereby play a central role in transcription regulation,
DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be
involved in stable X chromosome inactivation

Gene Wiki entry for H2AFY2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the H2AFY2 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   Spz1   oct-B3   oct-B2   POU2F2   POU2F1   POU2F1a   c-Myb   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidH2AFY2 promoter sequence
   Search SABiosciences Chromatin IP Primers for H2AFY2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H2AFY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

H2AFY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H2AFY2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P071812:  view genomic region     (about GC identifiers)

Start:
71,812,357 bp from pter      End:
71,872,040 bp from pter
Size:
59,684 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H2AW_HUMAN, Q9P0M6 (See protein sequence)
Recommended Name: Core histone macro-H2A.2  
Size: 372 amino acids; 40058 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers
Subcellular location: Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in
senescence-associated heterochromatin
1 PDB 3D structure from and Proteopedia for H2AFY2:
2XD7 (3D)    
Secondary accessions: Q5SQT2

Explore the universe of human proteins at neXtProt for H2AFY2: NX_Q9P0M6

Explore proteomics data for H2AFY2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P0M6

  • H2AFY2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    H2AFY2 Protein Expression
    REFSEQ proteins: NP_061119.1  
    ENSEMBL proteins: 
     ENSP00000362352   ENSP00000404584  

    Human Recombinant Protein Products for H2AFY2: 
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    Novus Biologicals H2AFY2 Protein
    Novus Biologicals H2AFY2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for H2AFY2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0001740Barr body IDA11331621
    GO:0005634nucleus IDA--

    H2AFY2 for ontologies           About GeneDecksing



    H2AFY2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for H2AFY2 

    Assay Products for H2AFY2: 
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    Cloud-Clone Corp. ELISAs for H2AFY2 
    Cloud-Clone Corp. CLIAs for H2AFY2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RIH: Histones / Replication-independent

    5 InterPro protein domains:
     IPR009072 Histone-fold
     IPR002589 A1pp
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A
     IPR021171 Core_histone_macro-H2A

    Graphical View of Domain Structure for InterPro Entry Q9P0M6

    ProtoNet protein and cluster: Q9P0M6

    2 Blocks protein domains:
    IPB002119 Histone H2A
    IPB002589 Protein of unknown function Appr-1


    UniProtKB/Swiss-Prot: H2AW_HUMAN, Q9P0M6
    Similarity: Contains 1 histone H2A domain
    Similarity: Contains 1 Macro domain


    H2AFY2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2AW_HUMAN, Q9P0M6
    Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses
    transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular
    machineries which require DNA as a template. Histones thereby play a central role in transcription regulation,
    DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be
    involved in stable X chromosome inactivation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    H2AFY2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for H2AFY2:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for H2AFY2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for H2AFY2 
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    SwitchGear 3'UTR luciferase reporter plasmidH2AFY2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for H2AFY2
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2AFY2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for H2AFY2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2         Kegg Pathways  (Kegg details for H2AFY2):
        Alcoholism
    Systemic lupus erythematosus


    H2AFY2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H2AFY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for H2AFY2 (Q9P0M63 ENSP000003623524) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR6Q9NNW53I2D: score=1 
    EZH2ENSP000003201474STRING: ENSP00000320147
    HDAC2ENSP000003813314STRING: ENSP00000381331
    SUZ12ENSP000003165784STRING: ENSP00000316578
    HDGFENSP000003571894STRING: ENSP00000357189
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0007549dosage compensation IDA11331621
    GO:0016568chromatin modification IEA--

    H2AFY2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for H2AFY2 (H2AW)

    Search CenterWatch for drugs/clinical trials and news about H2AFY2 / H2AW

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for H2AFY2 gene: 
    NM_018649.2  

    Unigene Cluster for H2AFY2:

    H2A histone family, member Y2
    Hs.499953  [show with all ESTs]
    Unigene Representative Sequence: AL359572
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373255(uc001jqm.3) ENST00000455786

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate H2AFY2
    SwitchGear 3'UTR luciferase reporter plasmidH2AFY2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for H2AFY2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H2AFY2
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for H2AFY2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H2AFY2
    Sirion Biotech Customized lentivirus for stable overexpression of H2AFY2 
                         Customized lentivirus expression plasmids for stable overexpression of H2AFY2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for H2AFY2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H2AFY2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H2AFY2

    Additional mRNA sequence: 

    AF336304.1 AK022475.1 AK022776.1 AK131057.1 AL359572.1 BC016172.2 

    9 DOTS entries:

    DT.416777  DT.91766758  DT.100714171  DT.102829851  DT.91766762  DT.95312865  DT.100792928  DT.106028 
    DT.416778 

    24/207 AceView cDNA sequences (see all 207):

    AI674496 BM680187 BU623795 AI910812 CR592495 CN481762 BQ648649 AA283182 
    BM667074 CR623698 AA678734 AA633441 AA318946 AI744095 BF939160 CR613322 
    AK131057 CA390171 AK022776 AW136167 CR601217 BM682238 BI820969 BE464932 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    H2AFY2 expression in normal human tissues (normalized intensities)      H2AFY2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTTCCTC
    H2AFY2 Expression
    About this image


    H2AFY2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See H2AFY2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for H2AFY2

    SOURCE GeneReport for Unigene cluster: Hs.499953
        SABiosciences Custom PCR Arrays for H2AFY2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2AFY2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for H2AFY2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2afy21 , 5 H2A histone family, member Y21, 5 90.23(n)1
    98.39(a)1
      10 (32.27 cM)5
    4046341  NM_207000.21  NP_996883.11 
     617386655 
    chicken
    (Gallus gallus)
    Aves H2AFY21 H2A histone family, member Y2 80.2(n)
    90.32(a)
      423721  XM_421598.3  XP_421598.2 
    lizard
    (Anolis carolinensis)
    Reptilia H2AFY26
    H2A histone family, member Y2
    87(a)
    1 ↔ 1
    3(48801361-48832837)
    African clawed frog
    (Xenopus laevis)
    Amphibia h2afy2-prov2 H2A histone family, member Y2 76.1(n)    BC056065.1 
    zebrafish
    (Danio rerio)
    Actinopterygii h2afy21 H2A histone family, member Y2 70.03(n)
    74.93(a)
      558711  NM_001025502.1  NP_001020673.1 
    worm
    (Caenorhabditis elegans)
    Secernentea htas-16
    Protein HTAS-1
    40(a)
    1 → many
    IV(9682984-9683532)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HTA26
    HTA16
    Histone H2A, core histone protein required for chr...
    Histone H2A, core histone protein required for chr...
    59(a)
    59(a)
    many ↔ many
    many ↔ many
    II(235394-235792)
    IV(915530-915928)


    ENSEMBL Gene Tree for H2AFY2 (if available)
    TreeFam Gene Tree for H2AFY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for H2AFY2 gene
    H2AFB12  H2AFX2  H2AFB22  H2AFB32  H2AFY2  
    18/26 SIMAP similar genes for H2AFY2 using alignment to 2 protein entries:     H2AW_HUMAN (see all proteins) (see all similar genes):
    HIST1H2AA    HIST1H2AB    HIST1H2AE    HIST2H2AB    HIST3H2A    HIST1H2AC
    HIST1H2AD    HIST2H2AC    H2AFV    H2AFJ    H2AFX    H2AFZ
    HIST1H2AG    HIST1H2AH    HIST1H2AI    HIST1H2AJ    HIST1H2AK    HIST1H2AL

    H2AFY2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1181 SNPs in H2AFY2 are shown (see all 1181)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451958931,2
    --71810380(+) ATGTTC/TGGTAT 1 -- us2k10--------
    rs339192251,2
    C,F--71810578(+) CTATAA/GCAAAG 1 -- us2k112Minor allele frequency- G:0.46NA WA CSA EA 374
    rs1840019191,2
    --71810700(+) CCAACA/CAGTAT 1 -- us2k10--------
    rs1885384021,2
    --71810727(+) AACCAG/TTAAAT 1 -- us2k10--------
    rs1147509791,2
    C,F--71810951(+) GAAAAC/TTCCTG 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1423403121,2
    --71811073(+) CCCCAA/GGGGAT 1 -- us2k10--------
    rs1469150471,2
    --71811117(+) AAGAAG/TACTTT 1 -- us2k10--------
    rs1918344671,2
    --71811176(+) AGTGAA/GGTCAT 1 -- us2k10--------
    rs1393310341,2
    --71811660(+) CCTCTC/TACAGT 1 -- us2k10--------
    rs765045631,2
    F--71811671(+) CCTTTG/AACTGT 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for H2AFY2 (71812357 - 71872040 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for H2AFY2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819142CNV Gain19587683
    esv32737CNV Gain+Loss17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for H2AFY2:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    alzheimer's disease    prostate cancer
    prostatitis


    H2AFY2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): H2AFY2
    Human Genome Epidemiology (HuGE) Navigator: H2AFY2 (2 documents)

    Export disorders for H2AFY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for H2AFY2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with H2AFY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. (PubMed id 11331621)1, 2, 3, 9 Chadwick B.P. and Willard H.F. (2001)
    2. MACROH2A2, a new member of the MARCOH2A core histone family. (PubMed id 11262398)1, 2, 3 Costanzi C. and Pehrson J.R. (2001)
    3. Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (2010)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    5. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. (PubMed id 15621527)1, 2 Zhang R.... Adams P.D. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55506 HGNC: 14453 AceView: H2AFY2 Ensembl:ENSG00000099284 euGenes: HUgn55506
    ECgene: H2AFY2 Kegg: 55506 H-InvDB: H2AFY2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for H2AFY2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for H2AFY2 gene:
    Search GeneIP for patents involving H2AFY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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