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H2AFY Gene

protein-coding   GIFtS: 57

GC05M134697
H2A histone family, member Y
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for H2AFY

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
H2A.y 2, 3
H2A/y 2, 3
H2AF12M 2
H2AFJ 2
MACROH2A1 3
MACROH2A1.1 2
mH2A1 2, 3
macroH2A1.2 1, 2
Descriptions
H2A histone family, member Y 2
Histone macroH2A1 3
Medulloblastoma antigen MU-MB-50.205 3
histone macroH2A1.1 2
histone macroH2A1.2 2
External Ids
HGNC: 47401
Entrez Gene: 95552
UniProtKB: O753673
Ensembl: ENSG000001136487
Search outside databases for aliases for H2AFY gene

Previous GC identifers: GC05M134322 GC05M135237 GC05M134700 GC05M134746

Summaries
for H2AFY

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for H2AFY:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the
chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around
a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The
chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA
between the nucleosomes to form higher order chromatin structures. This gene encodes a member of
the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it
represses transcription and participates in stable X chromosome inactivation. Alternative splicing
results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: H2AY_HUMAN, O75367
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it
represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a
central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
DNA accessibility is regulated via a complex set of post-translational modifications of histones,
also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation.
Inhibits the binding of transcription factors and interferes with the activity of remodeling
SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces
an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose
and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation

Gene Wiki entry for H2AFY

Genomic Location
for H2AFY

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the H2AFY gene  

Entrez Gene cytogenetic band: 5q31.3-q32   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

H2AFY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M134697:     (about GC identifiers)

Start:
 134,697,970 bp from pter
End:
 134,763,476 bp from pter
Size:
 65,507 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000005.8  NT_034772.5  

Proteins
for H2AFY

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: H2AY_HUMAN, O75367 (See protein sequence)
Recommended Name: Core histone macro-H2A.1  
Size: 372 amino acids; 39617 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4
assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with SPOP. Part of a
complex consisting of H2AFY, CUL3 and SPOP. Interacts with HDAC1 and HDAC2 (By similarity)
Subcellular location: Nucleus. Note=Enriched in inactive X chromosome chromatin and in
senescence-associated heterochromatin
Miscellaneous: The number of individuals with antibodies against this antigen is 2-fold higher in
pediatric patients with cancer compared to healthy controls
PDB structures from and Proteopedia :
1U35 (3D)    1ZR3 (3D)    1ZR5 (3D)    2F8N (3D)    2FXK (3D)    
Secondary accessions: O75377 Q503A8 Q7Z5E3 Q96D41 Q9H8P3 Q9UP96
Alternative splicing: 2 isoforms:  O75367-1   O75367-2   

Post-translational modifications:

  • Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is
    mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is
    required for enrichment in inactive X chromosome chromatin1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (4 alternative transcripts): 
    NP_001035248.1  NP_004884.1  NP_613075.1  NP_613258.2  


    ENSEMBL proteins: 
    ENSP00000302572 ENSP00000353806 ENSP00000310169 ENSP00000378410 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (macroH2A.1)
    Human Recombinant Proteins from Abnova (H2AFY)
                   OriGene Purified Recombinant Human Proteins (see all 2): H2AFY  

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786 nucleosome NAS9714746
    GO:0001740 Barr body IDA11331621
    GO:0005634 nucleus IEA--
    GO:0005694 chromosome IEA--
    About this table

    Antibodies for H2AFY: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (macroH2A.1), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for H2AFY

    Assays for H2AFY: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for H2AFY

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro domains/families:
     IPR002589 A1pp
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A
     IPR009072 Histone-fold


       GeneDecks  H2AFY for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O75367

    ProtoNet protein and cluster: O75367

    2 Blocks protein families:
    IPB002119 Histone H2A
    IPB002589 Protein of unknown function Appr-1


    UniProtKB/Swiss-Prot: H2AY_HUMAN, O75367
    Similarity: Contains 1 histone H2A domain
    Similarity: Contains 1 Macro domain

    Gene Function
    for H2AFY

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (H2AFY)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (H2AFY)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_138609

                  Applied Biosystems Silencer® siRNAs for H2AFY

                  Sigma-Aldrich siRNA for H2AFY  
                         Sigma-Aldrich shRNA for H2AFY  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for H2AFY
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001040158
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001040158
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_001040158 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_138610

    UniProtKB/Swiss-Prot: H2AY_HUMAN, O75367
    Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it
    represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a
    central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
    DNA accessibility is regulated via a complex set of post-translational modifications of histones,
    also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation.
    Inhibits the binding of transcription factors and interferes with the activity of remodeling
    SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces
    an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose
    and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation

    Genatlas biochemistry entry for H2AFY:
    core histone family H2A,replacement subtype replication independent protein,species H2A-Z

    1 MGI mutant phenotype (inferred from 1 allele) (MGI details for H2afy):

    normal

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding NAS9714746
    About this table

    Pathways & Interactions
    for H2AFY

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Kegg Pathway  (Kegg details for H2AFY):
     hsa05322 Systemic lupus erythematosus

       GeneDecks  H2AFY for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  H2AFY 


    5/8 Interacting proteins for H2AFY (O753672 ENSP000003538063) via UniProtKB, MINT, and/or STRING (see all 8 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF2P153362MINT-3377900
    SPOPENSP000002403273STRING (score=.968)
    SIRT1ENSP000002120153STRING (score=.92)
    PARP1ENSP000003557593STRING (score=.834)
    NASPENSP000003455323STRING (score=.729)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334 nucleosome assembly NAS9714746
    GO:0007549 dosage compensation IDA15053874
    GO:0016568 chromatin modification IEA--
    About this table

    Drugs & Compounds
    for H2AFY

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for H2AFY

    Transcripts
    for H2AFY

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (H2AFY)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (H2AFY)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_138609

                  Sigma-Aldrich siRNA for H2AFY  
                         Sigma-Aldrich shRNA for H2AFY  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001040158  NM_004893  NM_138609  NM_138610  

    REFSEQ mRNAs for H2AFY gene (4 alternative transcripts): 

    NM_001040158.1   NM_004893.2   NM_138609.2   NM_138610.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001040158  NM_004893  NM_138609  NM_138610  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001040158
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001040158
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_001040158 

    Additional cDNA sequence: 

    AK092789.1 BC045570.1 

    24/47 DOTS entries (see all 47 ):

    DT.100840236  DT.75173091  DT.92460030  DT.40275695  DT.119946  DT.444170  DT.40115725  DT.100887457 
    DT.95095529  DT.92337776  DT.119945  DT.101986415  DT.100887453  DT.97762941  DT.97860304  DT.40235411 
    DT.92460019  DT.100887462  DT.100887463  DT.120802211  DT.92460032  DT.91675072  DT.92460020  DT.120802203 

    10 AceView cDNA sequences:

    BM684468 AI192048 AA353890 CF145353 BC045570 BM930971 AK092789 BI560542 
    BE222348 BG720657 

    highest scoring ESTs for H2AFY:

    AF054174 AA353890 AV738921 BC013331 BF214824 BF241778 BG282964 BG497635 BG528972 BG720657 

    Unigene Clusters for H2AFY:

    H2A histone family, member Y
    Hs.420272  [show with all ESTs], Hs.599225  [show with all ESTs]
    Unigene Representative Sequences: AB209490, AK092789


    GeneLoc Exon Structure

    5/23 Alternative Splicing Database (ASD) splice patterns (SP) for H2AFY (see all 23 )

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^
    SP1:                                            -                                                                             -                 -     -     -   
    SP2:                                                                                                                          -                 -     -     -   
    SP3:                                            -                                                                             -                 -     -     -   
    SP4:                                            -                                                                             -                 -     -     -   
    SP5:                                            -                                                                             -                 -     -     -   

    ExUns: 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14
    SP1:        -                                             
    SP2:        -                                             
    SP3:        -                                             
    SP4:  -                                                   
    SP5:  -     -                                             

    About this scheme

    ECgene alternative splicing isoforms for H2AFY

    4 Ensembl transcripts including schematic representations:
    ENST00000304332  ENST00000360597  ENST00000312469  ENST00000394958  

    Expression
    for H2AFY

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    H2AFY expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for H2AFY

    1 / 2 / 3

    12 probe-sets matching H2AFY gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		87315_at2, 3 U95-E 1 1.00 1.00 0.79 0.75 AI797168 0.60 1.00 0.82 1

    		49024_at2, 3 U95-B 1 1.00 1.00 0.70 0.76 AI078502 0.60 1.00 0.82 1

    		36576_at2, 3 U95-A 1 1.00 1.00 0.75 1.51 AF054174 1.00 1.00 1.00 1

    		226840_at2, 3 U133-B 1 1.00 1.00 -- -- AW291297 0.40 1.00 0.76 1

    		214501_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF044286 0.60 1.00 0.82 1

    		214500_at2, 3 U133-A 1 1.00 1.00 -- -- AF044286 0.60 1.00 0.82 1

    		207168_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004893 0.60 1.00 0.82 1

    		1558780_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		226840_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		214501_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		214500_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		207168_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.420272 Hs.599225

    Expression variation in blood from EXPOLDB for H2AFY

    UniProtKB/Swiss-Prot: H2AY_HUMAN, O75367
    Tissue specificity: Ubiquitous

    Orthologs
    for H2AFY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for H2AFY gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LOC4815141   -- similar to H2A histone family, member Y isoform 3 93.73(n)
    100(a)    		 481514  XM_538635.2  XP_538635.2 
    chimpanzee
    (Pan troglodytes)    		 LOC4620761   -- similar to histone macroH2A1.1 99.91(n)
    100(a)    		 462076  XM_001168507.1  XP_001168507.1 
    cow
    (Bos taurus)    		 H2AFY1   -- H2A histone family, member Y 93.44(n)
    99.46(a)    		 532990  NM_001046340.1  NP_001039805.1 
    rat
    (Rattus norvegicus)    		 H2afy1   -- H2A histone family, member Y 89.94(n)
    98.38(a)    		 29384  NM_017182.2  NP_058878.1 
    mouse
    (Mus musculus)    		 H2afy1, 5 135
    		 H2A histone family, member Y1, 5 90.68(n)1
    98.39(a)1    		 269141  NM_012015.11  NP_036145.11 
     AB0719885  AF1233125  (see all 17)
    About this table        Species with no ortholog for H2AFY

    ENSEMBL Gene Tree for H2AFY

    Paralogs
    for H2AFY

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for H2AFY gene
    H2AFY22  H2AFV2  H2AFZ2  

    SNPs/Variants
    for H2AFY

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/264 NCBI SNPs in H2AFY are shown (see all 264 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 133)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs22769901,2
    		A,C,F134763520(-) TTTCGG/ACCTGT 4 -- ng313Minor allele frequency- A:0.02MN EA 540
    rs26172601,2
    		C,F,H134763757(-) AATTAC/TCTCCA 4 -- ng317Minor allele frequency- T:0.06EA NA EU WA 466
    rs22528611,2
    		C,F134763407(-) AACCGC/TTTCCA 4 -- ng31 ut51 ese32Minor allele frequency- T:0.04EA MN 1684
    rs22528591,2
    		A,C134763533(-) GCGGCT/CCCTCC 4 -- ng31 trp36Minor allele frequency- C:0.03EA NA MN 584
    --
    rs49889621,2
    		H134706963(+) CCCAAA/CCTGGA 4 V/G mis14Minor allele frequency- C:0.00EU EA WA 406
    --
    rs171682531,2
    		F134762998(-) GCGTCC/TGGGGT 4 -- ng31 int12Minor allele frequency- T:0.01MN EA 356
    --
    rs49889641,2
    		H134706961(+) ACCCCA/CAACTG 4 W/G mis14Minor allele frequency- C:0.00EU EA WA 416
    --
    rs26520701,2
    		A134765163(+) TATTAG/TAAATA 1 -- ng310--------
    rs32100471,2
    		C,F,H,O134698664(-) GTGTCT/CACAAT 4 S/S syn1 ese34Minor allele frequency- C:0.08MN EU EA 464
    rs37337281,2
    		C,F,H134698640(-) AAAACG/AGTGTA 4 T/T syn19Minor allele frequency- A:0.03EA EU WA 2324
    About this table

    HapMap Linkage Disequilibrium images for H2AFY (up to first 250kb)

    Disorders & Mutations
    for H2AFY

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 610054

    Human Genome Epidemiology Navigator: H2AFY (1 document)

    Medical News
    for H2AFY

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for H2AFY

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/40 PubMed articles for H2AFY gene (see all 40 ):

    Search for H2AFY

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
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    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing H2AFY

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 9555 HGNC: 4740 AceView: H2AFY.1 Ensembl:ENSG00000113648 euGenes: HUgn9555
    ECgene: H2AFY H-InvDB: H2AFY

    Other Databases showing H2AFY

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing H2AFY

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for H2AFY

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for H2AFY

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for H2AFY:
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    		  Free SNP selection tool



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     Search for Antibodies & Assays

     Recombinant Proteins
    (macroH2A.1)
     Antibodies (macroH2A.1)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for H2AFY




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for H2AFY

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