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Aliases & Descriptions for H2AFJ
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ10903 1, 2 | | FLJ52230 2 | | H2AJ 2 | | H2a/j 3 | | MGC921 1, 2 |
| | | Descriptions |
|---|
| H2A histone family, member J 2 |
|
| | Search outside databases for aliases for H2AFJ genePrevious GC identifers: GC12P014666 GC12P015072 GC12P014827 |
Summaries for H2AFJ(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for H2AFJ: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. [provided by RefSeq] UniProtKB/Swiss-Prot: H2AJ_HUMAN, Q9BTM1Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelingGene Wiki entry for H2AFJ |
Genomic Location for H2AFJ
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the H2AFJ gene 
Entrez Gene cytogenetic band: 12p12 Ensembl cytogenetic band: 12p12.3 HGNC cytogenetic band: 12p12.3H2AFJ Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P014818:
(about GC identifiers)
Start:
|
14,818,537 bp from pter |
End:
|
14,822,203 bp from pter |
Size:
|
3,667 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009714.16
| Proteins for H2AFJ
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: H2AJ_HUMAN, Q9BTM1 (See
protein sequence)Recommended Name: Histone H2A.J Size: 129 amino acids; 14019 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q9NV63Alternative splicing: 2 isoforms: Q9BTM1-1 Q9BTM1-2 Post-translational modifications:
Monoubiquitination of Lys-120 gives a specific tag for epigenetic transcriptional repression (By similarity)1
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity)1
REFSEQ proteins: NP_808760.1
ENSEMBL proteins: ENSP00000228929 ENSP00000373730
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: H2AFJ 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for H2AFJ: Assays for H2AFJ: | Protein
Domains/ Families for H2AFJ(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BTM1
ProtoNet protein and cluster: Q9BTM1 1 Blocks protein family: IPB002119 Histone H2A
UniProtKB/Swiss-Prot: H2AJ_HUMAN, Q9BTM1Similarity: Belongs to the histone H2A family | Gene Function for H2AFJ
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_177925
Applied Biosystems Silencer® siRNAs for H2AFJ
Sigma-Aldrich siRNA for H2AFJ  Sigma-Aldrich shRNA for H2AFJ  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_177925                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_177925                                  untagged cDNA clones in CMV expression vector (see all 2): NM_018267 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018267
UniProtKB/Swiss-Prot: H2AJ_HUMAN, Q9BTM1Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | About this table | Pathways & Interactions for H2AFJ
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
IEA | -- | About this table
|
Drugs & Compounds for H2AFJ(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for H2AFJ
|
Transcripts for H2AFJ(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_177925
Sigma-Aldrich siRNA for H2AFJ  Sigma-Aldrich shRNA for H2AFJ  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_177925 REFSEQ mRNAs for H2AFJ gene: NM_177925.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_177925               OriGene GFP tagged cDNA clone in CMV expression vector: NM_177925                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_177925                                  untagged cDNA clones in CMV expression vector (see all 2): NM_018267  Additional cDNA sequence: AK303301.1 AL133626.1 4 DOTS entries: DT.317312 DT.442835 DT.40221155 DT.121130338 24/202 AceView cDNA sequences (see all 202
):AI657138 CF130059 BQ011128 BC003602 AW614368 BM673012 BQ949135 BG164807 CR625218 CA426927 BU857464 AI826325 BE855619 AI051983 CD671508 AI089875 BQ011207 BP371955 BP371825 BQ636090 BF437356 CD671507 BM760307 AA641993
highest scoring ESTs for H2AFJ:AA641993 AA975581 AA975585 AA989504 AI051983 AI085976 AA136886 AA143420 AA416963 AA507753 Unigene Clusters for H2AFJ: H2A histone family, member J Hs.524280 [show with all ESTs], Hs.718660 [show with all ESTs]Unigene Representative Sequences: NM_177925, AL133626
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000228929
ENST00000389078
|
Expression for H2AFJ
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| H2AFJ expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for H2AFJ
1 / 2 / 3 11 probe-sets matching H2AFJ gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAGGGCCGGT
SOURCE GeneReport for Unigene clusters: Hs.524280 Hs.718660
|
Orthologs for H2AFJ
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for H2AFJ gene from 5/12 species (see all 12
)
About this table Species with no ortholog for H2AFJ
ENSEMBL Gene Tree for H2AFJ | Paralogs for H2AFJ(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for H2AFJ gene
- HIST2H2AB2 HIST1H4A2 HIST1H2AE2 HIST1H2AB2
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for H2AFJ(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for H2AFJ (up to first 250kb)
|
Disorders & Mutations for H2AFJ
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for H2AFJ(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for H2AFJ (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for H2AFJ gene (see all 12
): |
Search for H2AFJ
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing H2AFJ
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing H2AFJ
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H2AFJ(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for H2AFJ(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for H2AFJ:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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