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Aliases &
Descriptions
for H2AFB3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| H2A.Bbd 3 | | H2ABBD 2, 3 | | H2AFB 2, 3 | | H2AFB2 2 | | OTTHUMP00000024254 2 |
| | | Descriptions |
|---|
| H2A Barr body-deficient 3 | | H2A histone family, member B 1 | | H2A histone family, member B3 2 | | histone variant H2A, Barr-body deficient 2 |
|
| |
Search outside databases for aliases for H2AFB3 genePrevious GC identifer: GC0XP154174 |
Summaries
for H2AFB3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for H2AFB3:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the
chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around
a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The
chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA
between the nucleosomes to form higher order chromatin structures. This gene encodes a member of
the histone H2A family. This gene is part of a region that is repeated three times on chromosome
X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents
the most telomeric copy. [provided by RefSeq]
UniProtKB/Swiss-Prot: H2AB2_HUMAN, P0C5Z0Function: Atypical histone H2A which can replace conventional H2A in some nucleosomes. Nucleosomes
wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which
require DNA as a template. Histones thereby play a central role in transcription regulation, DNA
repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex
set of post-translational modifications of histones, also called histone code, and nucleosome
remodeling. Nucleosomes containing this histone are less rigid and organize only 118 base pair of
DNA instead of 147 in classical nucleosomes. They are associated with transcriptionally active
chromatin and excluded form Barr bodies |
Genomic Location
for H2AFB3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the H2AFB3 gene 
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28H2AFB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM154342:
(about GC identifiers)
Start:
|
154,342,270 bp from pter |
End:
|
154,342,860 bp from pter |
Size:
|
591 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011726.13
| Proteins
for H2AFB3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: H2AB2_HUMAN, P0C5Z0 (See
protein sequence)Recommended Name: Histone H2A-Bbd type 2/3 Size: 115 amino acids; 12713 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4
assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a
proportion of nucleosomes, replacing one or more H2A molecules
Subcellular location: Nucleus. Note=Associated with the active X chromosome and with autosomes,
while it is absent from the inactive X chromosome and excluded from Barr bodies
Miscellaneous: In contrast to other H2A histones, it does not contain the conserved residues that
are the target of post-translational modifications
Secondary accessions: P98176 Q5TZB2 Q6FG78 Q96PR7REFSEQ proteins: NP_542451.1
ENSEMBL proteins: ENSP00000358452
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
Antibodies for H2AFB3:
Assays for H2AFB3: | Protein
Domains/
Families
for H2AFB3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P0C5Z0
ProtoNet protein and cluster: P0C5Z0 UniProtKB/Swiss-Prot: H2AB2_HUMAN, P0C5Z0Domain: The docking domain is responsible for the weaker heterodimerization with H2BSimilarity: Belongs to the histone H2A family | Gene Function
for H2AFB3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080720
 Applied Biosystems Silencer® siRNAs for H2AFB3
 Sigma-Aldrich siRNA for H2AFB3
Sigma-Aldrich shRNA for H2AFB3
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_080720
Myc/DDK tagged cDNA clone in CMV expression vector: NM_080720
untagged cDNA clone in CMV expression vector: NM_080720
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_080720
UniProtKB/Swiss-Prot: H2AB2_HUMAN, P0C5Z0Function: Atypical histone H2A which can replace conventional H2A in some nucleosomes. Nucleosomes
wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which
require DNA as a template. Histones thereby play a central role in transcription regulation, DNA
repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex
set of post-translational modifications of histones, also called histone code, and nucleosome
remodeling. Nucleosomes containing this histone are less rigid and organize only 118 base pair of
DNA instead of 147 in classical nucleosomes. They are associated with transcriptionally active
chromatin and excluded form Barr bodies | Pathways & Interactions
for H2AFB3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for H2AFB3 (ENSP000003584523) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds
for H2AFB3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for H2AFB3
|
Transcripts
for H2AFB3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080720
Sigma-Aldrich siRNA for H2AFB3
Sigma-Aldrich shRNA for H2AFB3
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_080720 REFSEQ mRNAs for H2AFB3 gene: NM_080720.1
OriGene GFP tagged cDNA clone in CMV expression vector: NM_080720
Myc/DDK tagged cDNA clone in CMV expression vector: NM_080720
untagged cDNA clone in CMV expression vector: NM_080720
Additional cDNA sequence: AF254576.1 BC101415.1 BC101417.1 BC101418.1 BC130510.1 BC130512.1 2 DOTS entries: DT.121303715 DT.410848 16 AceView cDNA sequences:AF254576 BM722299 AW183040 AI218259 BU740141 AA868831 AA428596 AA703660 AA432232 AA879431 AI018669 AA993742 AI205744 AA912999 AI204297 AI218431
 highest scoring ESTs for H2AFB3:AF254576 NM_080720 AI218431 AA428596 AA432232 AA703660 AA868831 AA879431 AA912999 AA993742 Unigene Cluster for H2AFB3: H2A histone family, member B3 Hs.632841 Unigene Representative Sequence: BC130512
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000369444
|
Expression
for H2AFB3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| H2AFB3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for H2AFB3
1 / 2 / 3 3 probe-sets matching H2AFB3 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCGAGGAGGA
SOURCE GeneReport for Unigene cluster: Hs.632841
|
Orthologs
for H2AFB3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for H2AFB3 gene from 4 species
About this table Species with no ortholog for H2AFB3
ENSEMBL Gene Tree for H2AFB3 | Paralogs
for H2AFB3(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for H2AFB3 gene
- H2AFB21 2 H2AFB11 2
|
SNPs/Variants
for H2AFB3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations
for H2AFB3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300445
|
Medical News
for H2AFB3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for H2AFB3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for H2AFB3 gene (see all 12
):- The DNA sequence of the human X chromosome. (PubMed id 15772651)3, 4 Ross M.T.... Bentley D.R. (2005)
- Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I. (PubMed id 16287874)3, 4 Okuwaki M.... Nagata K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA. (PubMed id 15257289)3, 4 Bao Y.... Luger K. (2004)
- A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome. (PubMed id 11266453)3, 4 Chadwick B.P. and Willard H.F. (2001)
- Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. (PubMed id 14657027)3 Lusic M....Giacca M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. (PubMed id 11689053)3 Deng L....Kashanchi F. (2001)
- Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. (PubMed id 11080476)3 Deng L.... Kashanchi F. (2000)
- Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. (PubMed id 9566873)3 El Kharroubi A....Martin M.A. (1998)
|
Search for H2AFB3
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing H2AFB3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing H2AFB3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H2AFB3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Histone_H2A |
|
| | | About This Section
| --
| Services
for H2AFB3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for H2AFB3:
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