H2AFB2 Gene
protein-coding GIFtS: 38
GCID: GC0XP154610
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H2A histone family, member B2
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Aliases
for H2AFB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| H2A Histone Family, Member B21 2 | | Histone H2A-Bbd Type 2/32 | | H2A.Bbd2 3 | | H2ABBD3 | | H2A Barr Body-Deficient2 3 | | H2AFB3 | | H2A Barr Body Deficient2 | | |
Export aliases for H2AFB2 gene to outside databasesPrevious GC identifers: GC00U917956 GC0XU900552 GC0XP154263 |
Summaries
for H2AFB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for H2AFB2:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs ofeach of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through theinteraction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times onchromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middlecopy. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: H2AB2_HUMAN, P0C5Z0Function: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with activetranscription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigidand organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes andassociate with the elongating form of RNA polymerase. They associate with spliceosome components and are required formRNA splicing. May participate in spermatogenesis
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Genomic Views
for H2AFB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the H2AFB2 gene promoter:
CREB Pax-5 deltaCREB Olf-1 AP-4 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for H2AFB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H2AFB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28H2AFB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP154610: view genomic region
(about GC identifiers)
Start:
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154,610,428 bp from pter |
End:
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154,610,944 bp from pter |
Size:
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517 bases |
Orientation:
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plus strand |
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Proteins
for H2AFB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: H2AB2_HUMAN, P0C5Z0 (See
protein sequence)Recommended Name: Histone H2A-Bbd type 2/3 Size: 115 amino acids; 12713 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in oneH3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing oneor more H2A molecules
Subcellular location: Nucleus. Chromosome. Note=Associated with the active X chromosome and with autosomes, while it isabsent from the inactive X chromosome and excluded from Barr bodies
Miscellaneous: In contrast to other H2A histones, it does not contain the conserved residues that are the target ofpost-translational modifications
Secondary accessions: A1L4E4 P98176 Q5TZB2 Q6FG78 Q96PR7Explore the universe of human proteins at neXtProt for H2AFB2: NX_P0C5Z0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0C5Z0
H2AFB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001017991.1
ENSEMBL proteins: ENSP00000346509
Human Recombinant Protein Products for H2AFB2:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
H2AFB2 for ontologies About GeneDecksing
H2AFB2 Antibody Products:
Assay Products for H2AFB2: |
Protein
Domains /
Families
for H2AFB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
H2AFB2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0C5Z0ProtoNet protein and cluster: P0C5Z0 UniProtKB/Swiss-Prot: H2AB2_HUMAN, P0C5Z0Domain: The docking domain is responsible for the weaker heterodimerization with H2BSimilarity: Belongs to the histone H2A family |
Function
for H2AFB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: H2AB2_HUMAN, P0C5Z0Function: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with activetranscription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigidand organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes andassociate with the elongating form of RNA polymerase. They associate with spliceosome components and are required formRNA splicing. May participate in spermatogenesis Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046982 | protein heterodimerization activity |
IEA | -- |
H2AFB2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H2AFB2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H2AFB2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for H2AFB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H2AFB2 |
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Pathways & Interactions
for H2AFB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Systemic lupus erythematosus | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for H2AFB2):
H2AFB2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H2AFB2
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
IDA | -- | | GO:0006397 | mRNA processing |
IMP | -- |
H2AFB2 for ontologies About GeneDecksing
|
Drugs & Compounds
for H2AFB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for H2AFB2
Search CenterWatch for drugs/clinical trials and news about H2AFB2 / H2AB2
|
Transcripts
for H2AFB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for H2AFB2 gene: NM_001017991.1 Unigene Cluster for H2AFB2: H2A histone family, member B2 Hs.534498 [show with all ESTs]Unigene Representative Sequence: AL6020621 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000354514(uc004fnh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H2AFB2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H2AFB2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: H2AFB2 (NM_001017991) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for H2AFB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H2AFB2 |
Additional cDNA sequence: AF254576.1 BC101415.1 BC101417.1 BC101418.1 BC130510.1 3 DOTS entries: DT.121303715 DT.410848 DT.99977757
GeneLoc Exon Structure
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Expression
for H2AFB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| H2AFB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGTTCACA
About this image
See H2AFB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for H2AFB2
SOURCE GeneReport for Unigene cluster: Hs.534498
UniProtKB/Swiss-Prot: H2AB2_HUMAN, P0C5Z0Tissue specificity: Present in mature sperm
SABiosciences Custom PCR Arrays for H2AFB2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for H2AFB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat H2AFB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H2AFB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H2AFB2 |
Orthologs
for H2AFB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for H2AFB2 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for H2AFB2 (if available)
TreeFam Gene Tree for H2AFB2 (if available) |
Paralogs
for H2AFB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for H2AFB2 gene
- H2AFB31 2 H2AFB11 2
18/25 SIMAP similar genes for H2AFB2 using alignment to 1 protein entry: H2AB2_HUMAN(see all similar genes):H2AFB1 H2AFX HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD
HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK
HIST1H2AL HIST1H2AM HIST1H2APS4 HIST2H2AA3 HIST2H2AA4 HIST2H2AB
H2AFB2 for paralogs About GeneDecksing
|
Genomic Variants
for H2AFB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for H2AFB2
1 CNV: 23331
7 Indels: 83875 83877 97122 97124 97121 97123 83878
2 Inversions: 37368 37367 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for H2AFB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
H2AFB2 for disorders About GeneDecksing
3  diseases for H2AFB2: About MalaCardssystemic lupus erythematosus lupus erythematosus malaria
Export disorders for H2AFB2 gene to outside databases
|
Publications
for H2AFB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for H2AFB2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with H2AFB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells. (PubMed id 22795134)1, 2 Tolstorukov M.Y....Park P.J. (2012)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I. (PubMed id 16287874)1, 2 Okuwaki M.... Nagata K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA. (PubMed id 15257289)1, 2 Bao Y.... Luger K. (2004)
- A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome. (PubMed id 11266453)1, 2 Chadwick B.P. and Willard H.F. (2001)
- H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis. (PubMed id 20008104)2 Ishibashi T.... Ausio J. (2010)
- Quickly evolving histones, nucleosome stability and chromatin folding: all about histone H2A.Bbd. (PubMed id 18329190)2 Gonzalez-Romero R.... Eirin-Lopez J.M. (2008)
- H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way. (PubMed id 17726088)2 Eirin-Lopez J.M.... Ausio J. (2008)
- Dissection of the unusual structural and functional properties of the variant H2A.Bbd nucleosome. (PubMed id 16957777)2 Doyen C.M.... Dimitrov S. (2006)
|
External Searches for H2AFB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing H2AFB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing H2AFB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H2AFB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for H2AFB2 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Histone_H2A |
|
| | |
About This Section
| Patent Information for H2AFB2 gene:
Search GeneIP for patents involving H2AFB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for H2AFB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for H2AFB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for H2AFB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for H2AFB2 | | | OriGene Protein Over-expression Lysate for H2AFB2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for H2AFB2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H2AFB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H2AFB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for H2AFB2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat H2AFB2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H2AFB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H2AFB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H2AFB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H2AFB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H2AFB2 |
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 | | | H2AFB2 Proteins, Antibodies, CLIAs, and ELISAs |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H2AFB2 |
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