Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

H2AFB1 Gene

protein-coding   GIFtS: 41
GCID: GC0XP154113

H2A Histone Family, Member B1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
H2A Histone Family, Member B11 2
H2A.Bbd2 3
H2A Barr Body-Deficient2 3
Histone H2A-Bbd Type 12

External Ids:    HGNC: 225161   Entrez Gene: 4743822   Ensembl: ENSG000001980827   UniProtKB: P0C5Y93   

Export aliases for H2AFB1 gene to outside databases

Previous GC identifers: GC00U917957 GC0XU900553 GC0XP153679 GC0XP153766 GC0XP142656


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for H2AFB1 Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated
three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record
represents the most centromeric copy which is in intron 22 of the F8 gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for H2AFB1 Gene: 
H2AFB1 (H2A histone family, member B1) is a protein-coding gene. Diseases associated with H2AFB1 include cryptorchidism, and systemic lupus erythematosus, and among its related super-pathways are Telomere Maintenance and Meiosis. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is H2AFY2.

UniProtKB/Swiss-Prot: H2AB1_HUMAN, P0C5Y9
Function: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with
active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this
histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively
transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome
components and are required for mRNA splicing. May participate in spermatogenesis

Gene Wiki entry for H2AFB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the H2AFB1 gene promoter:
         Pax-5   Olf-1   AP-4   Nkx2-5   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidH2AFB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for H2AFB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H2AFB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

H2AFB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H2AFB1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP154113:  view genomic region     (about GC identifiers)

Start:
154,113,317 bp from pter      End:
154,113,833 bp from pter
Size:
517 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H2AB1_HUMAN, P0C5Y9 (See protein sequence)
Recommended Name: Histone H2A-Bbd type 1  
Size: 115 amino acids; 12697 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes,
replacing one or more H2A molecules
Subcellular location: Nucleus. Chromosome. Note=Associated with the active X chromosome and with autosomes, while
it is absent from the inactive X chromosome and excluded from Barr bodies
Miscellaneous: In contrast to other H2A histones, it does not contain the conserved residues that are the target
of post-translational modifications
Secondary accessions: A0PK90 P98176 Q5TZB2 Q6FG78 Q96PR7

Explore the universe of human proteins at neXtProt for H2AFB1: NX_P0C5Y9

Explore proteomics data for H2AFB1 at MOPED 

H2AFB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

H2AFB1 Protein Expression

REFSEQ proteins: NP_001017990.1  
ENSEMBL proteins: 
 ENSP00000346450  
Reactome Protein details: P0C5Y9
Human Recombinant Protein Products for H2AFB1: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for H2AFB1
OriGene Protein Over-expression Lysate for H2AFB1
OriGene MassSpec for H2AFB1 
OriGene Custom Protein Services for H2AFB1
GenScript Custom Purified and Recombinant Proteins Services for H2AFB1
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for H2AFB1 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000786nucleosome ----
GO:0000788nuclear nucleosome IDA--
GO:0005634nucleus ----
GO:0035327transcriptionally active chromatin IDA--

H2AFB1 for ontologies           About GeneDecksing



H2AFB1 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of H2AFB1
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for H2AFB1
GenScript Custom Superior Antibodies Services for H2AFB1
Search for Antibodies for H2AFB1 at Abcam
Cloud-Clone Corp. Antibodies for H2AFB1 
Search ThermoFisher Antibodies for H2AFB1
LSBio Antibodies in human, mouse, rat for H2AFB1 

Assay Products for H2AFB1: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for H2AFB1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for H2AFB1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for H2AFB1 
Cloud-Clone Corp. CLIAs for H2AFB1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RIH: Histones / Replication-independent

3 InterPro protein domains:
 IPR009072 Histone-fold
 IPR007125 Histone_core_D
 IPR002119 Histone_H2A

Graphical View of Domain Structure for InterPro Entry P0C5Y9

ProtoNet protein and cluster: P0C5Y9

UniProtKB/Swiss-Prot: H2AB1_HUMAN, P0C5Y9
Domain: The docking domain is responsible for the weaker heterodimerization with H2B
Similarity: Belongs to the histone H2A family


H2AFB1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: H2AB1_HUMAN, P0C5Y9
Function: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with
active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this
histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively
transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome
components and are required for mRNA splicing. May participate in spermatogenesis

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0046982protein heterodimerization activity IEA--
     
H2AFB1 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for H2AFB1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for H2AFB1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for H2AFB1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for H2AFB1 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H2AFB1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate H2AFB1
SwitchGear 3'UTR luciferase reporter plasmidH2AFB1 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for H2AFB1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H2AFB1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for H2AFB1
Sirion Biotech Customized adenovirus for overexpression of H2AFB1

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for H2AFB1 (see all 6)
OriGene ORF clones in mouse, rat for H2AFB1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: H2AFB1 (NM_001017990)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for H2AFB1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H2AFB1
Sirion Biotech Customized lentivirus for stable overexpression of H2AFB1 
                     Customized lentivirus expression plasmids for stable overexpression of H2AFB1 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for H2AFB1
Search LifeMap BioReagents cell lines for H2AFB1
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2AFB1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for H2AFB1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Packaging Of Telomere Ends
Packaging Of Telomere Ends0.56
Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
Telomere Maintenance0.56
Amyloids0.41
Nucleosome assembly0.46
2Meiotic Synapsis
Meiotic Synapsis0.70
Meiotic Recombination0.62
Meiosis0.70
Chromosome Maintenance0.56
3Alcoholism
Alcoholism0.34
Systemic lupus erythematosus0.34
4Cell Cycle
Cell Cycle0.84
5Disease
Disease

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/11        Reactome Pathways for H2AFB1 (see all 11)
    Telomere Maintenance
Nucleosome assembly
Cell Cycle
Deposition of New CENPA-containing Nucleosomes at the Centromere
Meiotic Recombination


2         Kegg Pathways  (Kegg details for H2AFB1):
    Alcoholism
Systemic lupus erythematosus


H2AFB1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H2AFB1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for H2AFB1 (ENSP000003464504) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CBX1ENSP000002256034STRING: ENSP00000225603
CBX3ENSP000003366874STRING: ENSP00000336687
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006334nucleosome assembly IDA--
GO:0006397mRNA processing IMP--

H2AFB1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for H2AFB1 (H2AB1)

Search CenterWatch for drugs/clinical trials and news about H2AFB1 / H2AB1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for H2AFB1 gene: 
NM_001017990.1  

Unigene Cluster for H2AFB1:

H2A histone family, member B1
Hs.592246  [show with all ESTs]
Unigene Representative Sequence: DB303349
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000354461(uc004fmu.3)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H2AFB1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate H2AFB1
SwitchGear 3'UTR luciferase reporter plasmidH2AFB1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for H2AFB1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H2AFB1
Clone
Products:
     
OriGene clones in human, mouse for H2AFB1 (see all 6)
OriGene ORF clones in mouse, rat for H2AFB1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: H2AFB1 (NM_001017990)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for H2AFB1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H2AFB1
Sirion Biotech Customized lentivirus for stable overexpression of H2AFB1 
                     Customized lentivirus expression plasmids for stable overexpression of H2AFB1 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for H2AFB1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat H2AFB1
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H2AFB1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H2AFB1

Additional mRNA sequence: 

BC128034.1 CR542230.1 

1 DOTS entry:

DT.99977757 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

H2AFB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
H2AFB1 Expression
About this image


See H2AFB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for H2AFB1

SOURCE GeneReport for Unigene cluster: Hs.592246

UniProtKB/Swiss-Prot: H2AB1_HUMAN, P0C5Y9
Tissue specificity: Present in mature sperm

    SABiosciences Custom PCR Arrays for H2AFB1
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for H2AFB1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat H2AFB1
Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H2AFB1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H2AFB1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2AFB1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for H2AFB1 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia H2afb15 H2A histone family, member B1   --   2 (12.81 cM) 17996417 
lizard
(Anolis carolinensis)
Reptilia HIST1H2AA6
Histone H2A
32(a)
1 → many
GL344481.1(11179-11601)
worm
(Caenorhabditis elegans)
Secernentea htas-16
Protein HTAS-1
24(a)
1 → many
IV(9682984-9683532)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HTA26
HTA16
Histone H2A, core histone protein required for chr...
Histone H2A, core histone protein required for chr...
34(a)
34(a)
many ↔ many
many ↔ many
II(235394-235792)
IV(915530-915928)


ENSEMBL Gene Tree for H2AFB1 (if available)
TreeFam Gene Tree for H2AFB1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for H2AFB1 gene
H2AFB21 2  H2AFB31 2  H2AFY22  H2AFX2  H2AFY2  
18/26 SIMAP similar genes for H2AFB1 using alignment to 1 protein entry:     H2AB1_HUMAN(see all similar genes):
H2AFB2    H2AFB3    H2AFX    HIST1H2AA    HIST1H2AB    HIST1H2AC
HIST1H2AD    HIST1H2AE    HIST1H2AG    HIST1H2AH    HIST1H2AI    HIST1H2AJ
HIST1H2AK    HIST1H2AL    HIST1H2AM    HIST1H2APS4    HIST2H2AA3    HIST2H2AA4

H2AFB1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
Structural Variations
     Database of Genomic Variants (DGV) 5 variations for H2AFB1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv508817CNV Insertion20534489
esv29972CNV Gain17803354
esv33784CNV Gain+Loss17666407
nsv499361OTHER Inversion21111241
nsv7470OTHER Inversion18451855

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing H2AFB1
DNA2.0 Custom Variant and Variant Library Synthesis for H2AFB1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for H2AFB1:    About MalaCards
cryptorchidism    systemic lupus erythematosus    lupus erythematosus


H2AFB1 for disorders           About GeneDecksing


Export disorders for H2AFB1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for H2AFB1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with H2AFB1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA. (PubMed id 15257289)1, 2 Bao Y.... Luger K. (2004)
  2. Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions. (PubMed id 8528212)1, 2 Naylor J.A....Giannelli F. (1995)
  3. Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells. (PubMed id 22795134)2 Tolstorukov M.Y....Park P.J. (2012)
  4. Analysis of the human HP1 interactome reveals novel bi nding partners. (PubMed id 21888893)1 Rosnoblet C....Angrand P.O. (2011)
  5. H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis. (PubMed id 20008104)2 Ishibashi T.... Ausio J. (2010)
  6. Quickly evolving histones, nucleosome stability and chromatin folding: all about histone H2A.Bbd. (PubMed id 18329190)2 Gonzalez-Romero R.... Eirin-Lopez J.M. (2008)
  7. H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way. (PubMed id 17726088)2 Eirin-Lopez J.M.... Ausio J. (2008)
  8. Dissection of the unusual structural and functional properties of the variant H2A.Bbd nucleosome. (PubMed id 16957777)2 Doyen C.M.... Dimitrov S. (2006)
  9. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
  10. Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I. (PubMed id 16287874)2 Okuwaki M.... Nagata K. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 474382 HGNC: 22516 Ensembl:ENSG00000198082 euGenes: HUgn474382 ECgene: H2AFB1 Kegg: 474382
H-InvDB: H2AFB1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for H2AFB1 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Histone_H2A

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for H2AFB1 gene:
Search GeneIP for patents involving H2AFB1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 EMD Millipore Mono- and Polyclonal Antibodies for the study of H2AFB1
 Browse for Gene Knock-down Tools from EMD Millipore
 Browse Kits and Assays available from EMD Millipore
 Browse Purified and Recombinant Proteins at EMD Millipore
 Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
 Browse Small Molecules at EMD Millipore
 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for H2AFB1  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for H2AFB1  
 OriGene MassSpec something-or-other for H2AFB1   OriGene clones in human, mouse for H2AFB1  
 OriGene qSTAR qPCR primer pairs in human, mouse for H2AFB1   OriGene Purified Protein for H2AFB1  
 OriGene ORF clones in mouse, rat for H2AFB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for H2AFB1   OriGene Custom Protein Services for H2AFB1  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat H2AFB1
 QIAGEN SeqTarget long-range PCR primers for resequencing H2AFB1
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H2AFB1
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H2AFB1
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H2AFB1
 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H2AFB1
 GenScript Custom Purified and Recombinant Proteins Services for H2AFB1 GenScript cDNA clones with any tag delivered in your preferred vector for H2AFB1
 GenScript Custom Assay Services for H2AFB1 GenScript Custom Superior Antibodies Services for H2AFB1
 GenScript Custom overexpressing Cell Line Services for H2AFB1 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in H2AFB1 promoter
 Search Chromatin IP Primers for H2AFB1
 RT2 qPCR Primer Assay in human, mouse, rat H2AFB1
 Search GNC Networks for H2AFB1
 SABiosciences Custom PCR Arrays for H2AFB1
 Search Tocris compounds for H2AFB1 (H2AB1)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Biologicals
 Novus Tissue Slides
 Search for Antibodies for H2AFB1 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for H2AFB1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Proteins for H2AFB1
 Antibodies for H2AFB1
 ELISAs for H2AFB1
 CLIAs for H2AFB1
 Search LifeMap BioReagents cell lines for H2AFB1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H2AFB1
 SwitchGear 3'UTR luciferase reporter plasmids for H2AFB1
 SwitchGear Promoter luciferase reporter plasmids for H2AFB1
 Search ThermoFisher Antibodies for H2AFB1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H2AFB1
 inGenious Targeting Laboratory - Custom generated mouse model solutions for H2AFB1
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for H2AFB1
Customized:
 lentivirus for stable overexpression of H2AFB1
 lentivirus expression plasmids for stable overexpression of H2AFB1
 adenovirus for overexpression of H2AFB1
 LSBio Antibodies in human, mouse, rat for H2AFB1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      H2AFB1 gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4