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H1FX Gene

protein-coding   GIFtS: 54
GCID: GC03M129033

H1 Histone Family, Member X

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
H1 Histone Family, Member X1 2
H1X2
Histone H1x2

External Ids:    HGNC: 47221   Entrez Gene: 89712   Ensembl: ENSG000001848977   OMIM: 6027855   UniProtKB: Q925223   

Export aliases for H1FX gene to outside databases

Previous GC identifers: GC00U990454 GC03U900028 GC03M130315 GC03M130354 GC03M130516 GC03M126418


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for H1FX Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene encodes a member of the histone H1 family. (provided by RefSeq, Jul 2008)

GeneCards Summary for H1FX Gene:
H1FX (H1 histone family, member X) is a protein-coding gene. Diseases associated with H1FX include treacher collins syndrome, and tonsillitis.

UniProtKB/Swiss-Prot: H1X_HUMAN, Q92522
Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures

Gene Wiki entry for H1FX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the H1FX gene promoter:
         HOXA9B   HOXA9   NRSF form 1   HSF1 (long)   Nkx2-5   NRSF form 2   c-Myb   Meis-1a   LyF-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidH1FX promoter sequence
   Search Chromatin IP Primers for H1FX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat H1FX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

H1FX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H1FX gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M129033:  view genomic region     (about GC identifiers)

Start:
129,033,614 bp from pter      End:
129,035,120 bp from pter
Size:
1,507 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: H1X_HUMAN, Q92522 (See protein sequence)
Recommended Name: Histone H1x  
Size: 213 amino acids; 22487 Da
1 PDB 3D structure from and Proteopedia for H1FX:
2LSO (3D)    

Explore the universe of human proteins at neXtProt for H1FX: NX_Q92522

Explore proteomics data for H1FX at MOPED

Post-translational modifications: 

  • Citrullination at Arg-62 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its
    displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell
    maintenance (By similarity)1
  • Ubiquitination2 at Lys47, Lys106
  • Modification sites at PhosphoSitePlus

  • See H1FX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006017.1  
    ENSEMBL proteins: 
     ENSP00000329662  

    H1FX Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for H1FX

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    Abcam antibodies for H1FX (Q92522, Q86WT7, Q2M2I2, P07305, Q8IZA3)
    Cloud-Clone Corp. Antibodies for H1FX
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    LSBio Antibodies in human, mouse, rat for H1FX

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    Cloud-Clone Corp. ELISAs for H1FX
    Cloud-Clone Corp. CLIAs for H1FX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RIH: Histones / Replication-independent

    3 InterPro protein domains:
     IPR005819 Histone_H5
     IPR011991 WHTH_DNA-bd_dom
     IPR005818 Histone_H1/H5_H15

    Graphical View of Domain Structure for InterPro Entry Q92522

    ProtoNet protein and cluster: Q92522

    1 Blocks protein domain: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H1X_HUMAN, Q92522
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    H1FX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H1X_HUMAN, Q92522
    Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    H1FX for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for H1FX:
     Decreased Hepatitis C virus re  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         1 MGI phenotypic allele for H1fx (no phenotypes)

    H1FX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out H1fxtm1(KOMP)Vlcg for H1FX

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for H1FX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for H1FX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for H1FX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for H1FX

    miRNA
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    miRTarBase miRNAs that target H1FX:
    hsa-mir-1 (MIRT023530), hsa-mir-92a-3p (MIRT049411), hsa-mir-34a-5p (MIRT025236)

    Block miRNA regulation of human, mouse, rat H1FX using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate H1FX:
    hsa-miR-607 hsa-miR-185* hsa-miR-3613-3p hsa-miR-24 hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidH1FX 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat H1FX

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H1FX

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H1FX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H1X_HUMAN, Q92522: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    H1FX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for H1FX About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    PKA Signaling0.56
    2Activation of the pre-replicative complex
    Cell cycle Start of DNA replication in early S phase0.53
    3Activation of DNA fragmentation factor
    Granzyme-A Pathway0.32
    4Packaging Of Telomere Ends
    Histone modification0.31
    5Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for H1FX
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for H1FX
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for H1FX
    Interactions:

        Search GeneGlobe Interaction Network for H1FX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for H1FX (Q925222, 3 ENSP000003296624) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DOT1LQ8TEK33, ENSP000003816574I2D: score=1 STRING: ENSP00000381657
    NPM1P067483, ENSP000002969304I2D: score=1 STRING: ENSP00000296930
    XBP1P178613, ENSP000002160374I2D: score=1 STRING: ENSP00000216037
    RRP1BQ146843, ENSP000003391454I2D: score=1 STRING: ENSP00000339145
    TOP1P113873, ENSP000003545224I2D: score=3 STRING: ENSP00000354522
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    H1FX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for H1FX (H1X)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for H1FX gene: 
    NM_006026.3  

    Unigene Cluster for H1FX:

    H1 histone family, member X
    Hs.75307  [show with all ESTs]
    Unigene Representative Sequence: BC000426
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000333762(uc003elx.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat H1FX using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate H1FX:
    hsa-miR-607 hsa-miR-185* hsa-miR-3613-3p hsa-miR-24 hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidH1FX 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for H1FX
    Predesigned siRNA for gene silencing in human, mouse, rat H1FX
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: H1FX (NM_006026)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for H1FX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H1FX
    Primer
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    OriGene qPCR primer pairs and template standards for H1FX
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat H1FX
      QuantiTect SYBR Green Assays in human, mouse, rat H1FX
      QuantiFast Probe-based Assays in human, mouse, rat H1FX

    Additional mRNA sequence: 

    BC000426.2 BC010435.1 D64142.1 

    17 DOTS entries:

    DT.87018044  DT.95264824  DT.95163620  DT.120864679  DT.100038883  DT.100795368  DT.100795367  DT.120864663 
    DT.120864671  DT.95163633  DT.92467341  DT.100795374  DT.120864662  DT.95163621  DT.97860663  DT.101979486 
    DT.95264825 

    2 AceView cDNA sequences:

    BM728289 AI283383 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    H1FX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTTTTTT
    H1FX Expression
    About this image


    H1FX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Lung (Respiratory System)
    H1FX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    H1FX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75307

    UniProtKB/Swiss-Prot: H1X_HUMAN, Q92522
    Tissue specificity: Expressed ubiquitously

        Custom PCR Arrays for H1FX
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H1FX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for H1FX gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H1fx1 , 5 H1 histone family, member X1, 5 79.96(n)1
    75.53(a)1
      6 (39.13 cM)5
    2435291  NM_198622.11  NP_941024.11 
     879804215 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041758.12   -- 81.5(n)    BC041758.1 
    zebrafish
    (Danio rerio)
    Actinopterygii h1fx6
    H1 histone family, member X
    51(a)
    1 ↔ 1
    6(40700381-40702677) ENSDARG00000054058


    ENSEMBL Gene Tree for H1FX (if available)
    TreeFam Gene Tree for H1FX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for H1FX gene
    5 SIMAP similar genes for H1FX using alignment to 1 protein entry:     H1X_HUMAN:
    HIST1H1E    HIST1H1C    HIST1H1B    HIST1H1D    HIST1H1A

    H1FX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for H1FX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877474CNV Loss21882294
    nsv829722CNV Gain17160897
    nsv822244CNV Gain20364138
    nsv520607CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing H1FX
    DNA2.0 Custom Variant and Variant Library Synthesis for H1FX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602785    OMIM disorders: --

    6 diseases for H1FX:    
    About MalaCards
    treacher collins syndrome    tonsillitis    cerebritis    thyroiditis
    endotheliitis    prostatitis


    H1FX for disorders           About GeneDecksing


    Export disorders for H1FX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for H1FX gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with H1FX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the cDNA encoding a novel subtype of histone H1. (PubMed id 8964515)1, 2, 3 Yamamoto T. and Horikoshi M. (Gene 1996)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Histone H1x is highly expressed in human neuroendocrine cells and tumours. (PubMed id 19108733)1, 9 Warneboldt J....Happel N. (BMC Cancer 2008)
    5. G1 phase-dependent nucleolar accumulation of human histone H1x. (PubMed id 17868027)1, 9 Stoldt S....Happel N. (Biol. Cell 2007)
    6. Characterisation of human histone H1x. (PubMed id 16006241)1, 9 Happel N....Doenecke D. (Biol. Chem. 2005)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    9. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8971 HGNC: 4722 AceView: H1FX Ensembl:ENSG00000184897 euGenes: HUgn8971
    ECgene: H1FX H-InvDB: H1FX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for H1FX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for H1FX gene:
    Search GeneIP for patents involving H1FX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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