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Aliases for H1FX Gene

Aliases for H1FX Gene

  • H1 Histone Family, Member X 2 3
  • Histone H1x 3
  • H1.10 3
  • H1X 3

External Ids for H1FX Gene

Previous GeneCards Identifiers for H1FX Gene

  • GC00U990454
  • GC03U900028
  • GC03M130315
  • GC03M130354
  • GC03M130516
  • GC03M129033
  • GC03M126418

Summaries for H1FX Gene

Entrez Gene Summary for H1FX Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H1 family. [provided by RefSeq, Jul 2008]

GeneCards Summary for H1FX Gene

H1FX (H1 Histone Family, Member X) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and E2F mediated regulation of DNA replication.

UniProtKB/Swiss-Prot for H1FX Gene

  • Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures

Gene Wiki entry for H1FX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H1FX Gene

Genomics for H1FX Gene

Regulatory Elements for H1FX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for H1FX Gene

129,314,771 bp from pter
129,316,277 bp from pter
1,507 bases
Minus strand

Genomic View for H1FX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for H1FX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1FX Gene

Proteins for H1FX Gene

  • Protein details for H1FX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone H1x
    Protein Accession:
    Secondary Accessions:

    Protein attributes for H1FX Gene

    213 amino acids
    Molecular mass:
    22487 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for H1FX Gene

neXtProt entry for H1FX Gene

Proteomics data for H1FX Gene at MOPED

Post-translational modifications for H1FX Gene

  • Citrullination at Arg-62 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • Ubiquitination at Lys47 and Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for H1FX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H1FX Gene

Domains for H1FX Gene

Gene Families for H1FX Gene

  • RIH :Histones / Replication-independent

Protein Domains for H1FX Gene

Suggested Antigen Peptide Sequences for H1FX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92522
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1FX: view

Function for H1FX Gene

Molecular function for H1FX Gene

UniProtKB/Swiss-Prot Function:
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures

Gene Ontology (GO) - Molecular Function for H1FX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with H1FX: view
genes like me logo Genes that share phenotypes with H1FX: view

miRNA for H1FX Gene

miRTarBase miRNAs that target H1FX

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H1FX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for H1FX Gene

Localization for H1FX Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1FX Gene

Nucleus. Chromosome.

Subcellular locations from

Jensen Localization Image for H1FX Gene COMPARTMENTS Subcellular localization image for H1FX gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for H1FX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with H1FX: view

Pathways for H1FX Gene

genes like me logo Genes that share pathways with H1FX: view

Pathways by source for H1FX Gene

Gene Ontology (GO) - Biological Process for H1FX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
genes like me logo Genes that share ontologies with H1FX: view

Transcripts for H1FX Gene

mRNA/cDNA for H1FX Gene

(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for H1FX Gene

H1 histone family, member X:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H1FX

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for H1FX Gene

No ASD Table

Relevant External Links for H1FX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for H1FX Gene

mRNA expression in normal human tissues for H1FX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for H1FX Gene

This gene is overexpressed in Tlymphocyte (24.6) and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for H1FX Gene

SOURCE GeneReport for Unigene cluster for H1FX Gene Hs.75307

mRNA Expression by UniProt/SwissProt for H1FX Gene

Tissue specificity: Expressed ubiquitously
genes like me logo Genes that share expressions with H1FX: view

Expression partners for H1FX Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for H1FX Gene

Orthologs for H1FX Gene

This gene was present in the common ancestor of chordates.

Orthologs for H1FX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia H1FX 35
  • 88.89 (n)
  • 90.61 (a)
H1FX 36
  • 91 (a)
(Canis familiaris)
Mammalia H1FX 35
  • 91.55 (n)
  • 89.2 (a)
(Mus musculus)
Mammalia H1fx 35
  • 79.96 (n)
  • 75.53 (a)
H1fx 16
H1fx 36
  • 79 (a)
(Pan troglodytes)
Mammalia H1FX 35
  • 99.22 (n)
  • 99.06 (a)
H1FX 36
  • 99 (a)
(Rattus norvegicus)
Mammalia H1fx 35
  • 77.95 (n)
  • 72.4 (a)
(Monodelphis domestica)
Mammalia H1FX 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia H1FX 36
  • 75 (a)
(Danio rerio)
Actinopterygii h1fx 36
  • 51 (a)
Species with no ortholog for H1FX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for H1FX Gene

Gene Tree for H1FX (if available)
Gene Tree for H1FX (if available)

Paralogs for H1FX Gene

Selected SIMAP similar genes for H1FX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with H1FX: view

No data available for Paralogs for H1FX Gene

Variants for H1FX Gene

Structural Variations from Database of Genomic Variants (DGV) for H1FX Gene

Variant ID Type Subtype PubMed ID
nsv829722 CNV Gain 17160897
nsv877474 CNV Loss 21882294
nsv520607 CNV Gain+Loss 19592680
nsv822244 CNV Gain 20364138

Relevant External Links for H1FX Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for H1FX Gene

Disorders for H1FX Gene

No disorders were found for H1FX Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for H1FX Gene

Publications for H1FX Gene

  1. Cloning of the cDNA encoding a novel subtype of histone H1. (PMID: 8964515) Yamamoto T. … Horikoshi M. (Gene 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Characterisation of human histone H1x. (PMID: 16006241) Happel N. … Doenecke D. (Biol. Chem. 2005) 3 23
  4. G1 phase-dependent nucleolar accumulation of human histone H1x. (PMID: 17868027) Stoldt S. … Happel N. (Biol. Cell 2007) 3 23
  5. Histone H1x is highly expressed in human neuroendocrine cells and tumours. (PMID: 19108733) Warneboldt J. … Happel N. (BMC Cancer 2008) 3 23

Products for H1FX Gene

Sources for H1FX Gene

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