H1FX Gene
protein-coding GIFtS: 52
GCID: GC03M129033
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H1 histone family, member X
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Aliases
for H1FX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| H1 Histone Family, Member X1 2 | | H1X1 2 | | MGC159591 | | MGC83501 | | Histone H1x2 |
Export aliases for H1FX gene to outside databasesPrevious GC identifers: GC00U990454 GC03U900028 GC03M130315 GC03M130354 GC03M130516 GC03M126418 |
Summaries
for H1FX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for H1FX:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs ofeach of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through theinteraction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.This gene encodes a member of the histone H1 family. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: H1X_HUMAN, Q92522Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures
Gene Wiki entry for H1FX
|
Genomic Views
for H1FX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the H1FX gene promoter:
HOXA9B HOXA9 NRSF form 1 HSF1 (long) Nkx2-5 NRSF form 2 c-Myb Meis-1a LyF-1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for H1FX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H1FX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.3 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21.3H1FX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M129033: view genomic region
(about GC identifiers)
Start:
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129,033,614 bp from pter |
End:
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129,035,120 bp from pter |
Size:
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1,507 bases |
Orientation:
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minus strand |
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Proteins
for H1FX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: H1X_HUMAN, Q92522 (See
protein sequence)Recommended Name: Histone H1x Size: 213 amino acids; 22487 Da
Subcellular location: Nucleus. Chromosome
1 PDB 3D structure from  and Proteopedia  for H1FX:2LSO (3D)
Explore the universe of human proteins at neXtProt for H1FX: NX_Q92522
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92522
H1FX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006017.1
ENSEMBL proteins: ENSP00000329662
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
H1FX for ontologies About GeneDecksing
H1FX Antibody Products:
Assay Products for H1FX: |
Protein
Domains /
Families
for H1FX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
H1FX for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92522ProtoNet protein and cluster: Q92522 1 Blocks protein family: IPB005818 Histone H1/H5
UniProtKB/Swiss-Prot: H1X_HUMAN, Q92522Similarity: Belongs to the histone H1/H5 familySimilarity: Contains 1 H15 (linker histone H1/H5 globular) domain |
Function
for H1FX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: H1X_HUMAN, Q92522Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H1FX (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H1FX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: H1FX (NM_006026) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for H1FX | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H1FX |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
NAS | -- |
H1FX for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for H1FX:
Animal Models:
1 MGI phenotypic allele  for H1fx (no phenotypes)
H1FX for phenotypes About GeneDecksing
|
Pathways & Interactions
for H1FX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell cycle_Start of DNA replication in early S phase | | | 2 | Cell cycle Chromosome condensation in prometaphase | | | 3 | Activation of cAMP-Dependent PKA | | | 4 | Activation of DNA fragmentation factor | | | 5 | Signal transduction Activin A signaling regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for H1FX
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for H1FX
2  GeneGo (Thomson Reuters) Pathways for H1FX
H1FX for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H1FX
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/37 Interacting proteins for H1FX (Q925222, 3 ENSP000003296624) via UniProtKB, MINT, STRING, and/or I2D (see all 37)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
NAS | -- |
H1FX for ontologies About GeneDecksing
|
Drugs & Compounds
for H1FX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for H1FX
Search CenterWatch for drugs/clinical trials and news about H1FX / H1X
|
Transcripts
for H1FX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for H1FX gene: NM_006026.3 Unigene Cluster for H1FX: H1 histone family, member X Hs.75307 [show with all ESTs]Unigene Representative Sequence: BC0004261 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000333762(uc003elx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H1FX (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H1FX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: H1FX (NM_006026) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for H1FX | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H1FX |
Additional cDNA sequence: BC000426.2 BC010435.1 D64142.1 18 DOTS entries: DT.87018044 DT.95264824 DT.95163620 DT.120864679 DT.100795368 DT.100038883 DT.100795367 DT.120864663 DT.120864671 DT.95163633 DT.92467341 DT.100795374 DT.120864662 DT.95163621 DT.95264825 DT.97860663 DT.100730484 DT.101979486 2 AceView cDNA sequences: BM728289 AI283383
GeneLoc Exon Structure
|
Expression
for H1FX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| H1FX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCTTTTTT
About this image
See H1FX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for H1FX
SOURCE GeneReport for Unigene cluster: Hs.75307
UniProtKB/Swiss-Prot: H1X_HUMAN, Q92522Tissue specificity: Expressed ubiquitously
SABiosciences Custom PCR Arrays for H1FX
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for H1FX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat H1FX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H1FX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H1FX |
Orthologs
for H1FX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for H1FX gene from 7/25 species (see all 25) About this table
ENSEMBL Gene Tree for H1FX (if available)
TreeFam Gene Tree for H1FX (if available) |
Paralogs
for H1FX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for H1FX gene
- HIST1H1T2 HIST1H1D2 H1F02 H1FOO2 HIST1H1E2 HIST1H1C2 HIST1H1B2 HIST1H1A2
5 SIMAP similar genes for H1FX using alignment to 1 protein entry: H1X_HUMAN:HIST1H1E HIST1H1C HIST1H1B HIST1H1D HIST1H1A
H1FX for paralogs About GeneDecksing
|
Genomic Variants
for H1FX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for H1FX (129033614 - 129035120 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for H1FX
1 CNV: 50924 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H1FX |
|
Disorders
/ Diseases
for H1FX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
H1FX for disorders About GeneDecksing
OMIM gene information: 602785
OMIM disorders: --
2  diseases for H1FX: About MalaCardstreacher collins syndrome metastasis efficiency
Export disorders for H1FX gene to outside databases
|
Publications
for H1FX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for H1FX gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with H1FX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of the cDNA encoding a novel subtype of histone H1. (PubMed id 8964515)1, 2, 3 Yamamoto T. and Horikoshi M. (1996)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Histone H1x is highly expressed in human neuroendocrine cells and tumours. (PubMed id 19108733)1, 9 Warneboldt J....Happel N. (2008)
- G1 phase-dependent nucleolar accumulation of human histone H1x. (PubMed id 17868027)1, 9 Stoldt S....Happel N. (2007)
- Characterisation of human histone H1x. (PubMed id 16006241)1, 9 Happel N....Doenecke D. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
|
External Searches for H1FX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing H1FX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing H1FX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H1FX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for H1FX | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for H1FX gene:
Search GeneIP for patents involving H1FX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for H1FX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for H1FX | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for H1FX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for H1FX | | | OriGene Protein Over-expression Lysate for H1FX | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for H1FX | | OriGene 3'-UTR Clone for H1FX | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H1FX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H1FX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for H1FX | | OriGene Custom Protein Services for H1FX | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat H1FX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H1FX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H1FX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H1FX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H1FX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H1FX |
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| | | | Search Tocris compounds for H1FX |
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 | | | H1FX Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for H1FX |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H1FX |
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