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Aliases for H1FOO Gene

Aliases for H1FOO Gene

  • H1 Histone Family, Member O, Oocyte-Specific 2 3
  • Oocyte-Specific Linker Histone H1 3 4
  • Oocyte-Specific Histone H1 3 4
  • OsH1 3 4
  • Histone H1oo 3
  • H1.8 3
  • H1OO 4

External Ids for H1FOO Gene

Previous GeneCards Identifiers for H1FOO Gene

  • GC03P130543
  • GC03P130582
  • GC03P130744
  • GC03P129262
  • GC03P126645

Summaries for H1FOO Gene

Entrez Gene Summary for H1FOO Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for H1FOO Gene

H1FOO (H1 Histone Family, Member O, Oocyte-Specific) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication and Cell cycle_Chromosome condensation in prometaphase.

UniProtKB/Swiss-Prot for H1FOO Gene

  • May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).

Gene Wiki entry for H1FOO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H1FOO Gene

Genomics for H1FOO Gene

Regulatory Elements for H1FOO Gene

Genomic Location for H1FOO Gene

Start:
129,543,214 bp from pter
End:
129,551,467 bp from pter
Size:
8,254 bases
Orientation:
Plus strand

Genomic View for H1FOO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for H1FOO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1FOO Gene

Proteins for H1FOO Gene

  • Protein details for H1FOO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZA3-H1FOO_HUMAN
    Recommended name:
    Histone H1oo
    Protein Accession:
    Q8IZA3
    Secondary Accessions:
    • Q86WT7

    Protein attributes for H1FOO Gene

    Size:
    346 amino acids
    Molecular mass:
    35813 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for H1FOO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for H1FOO Gene

Proteomics data for H1FOO Gene at MOPED

Post-translational modifications for H1FOO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for H1FOO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H1FOO Gene

Domains for H1FOO Gene

Gene Families for H1FOO Gene

HGNC:
  • RIH :Histones / Replication-independent

Protein Domains for H1FOO Gene

Suggested Antigen Peptide Sequences for H1FOO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZA3

UniProtKB/Swiss-Prot:

H1FOO_HUMAN :
  • Q8IZA3
Domain:
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1FOO: view

Function for H1FOO Gene

Molecular function for H1FOO Gene

UniProtKB/Swiss-Prot Function: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).

Gene Ontology (GO) - Molecular Function for H1FOO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0031492 nucleosomal DNA binding ISS --
genes like me logo Genes that share ontologies with H1FOO: view

Phenotypes for H1FOO Gene

MGI mutant phenotypes for H1FOO:
inferred from 1 alleles
GenomeRNAi human phenotypes for H1FOO:
genes like me logo Genes that share phenotypes with H1FOO: view

Animal Models for H1FOO Gene

MGI Knock Outs for H1FOO:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H1FOO

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for H1FOO Gene

Localization for H1FOO Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1FOO Gene

Cytoplasm. Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for H1FOO Gene COMPARTMENTS Subcellular localization image for H1FOO gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for H1FOO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0001674 female germ cell nucleus IEA --
GO:0005634 nucleus ISS --
GO:0005730 NOT nucleolus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with H1FOO: view

Pathways for H1FOO Gene

genes like me logo Genes that share pathways with H1FOO: view

Pathways by source for H1FOO Gene

Gene Ontology (GO) - Biological Process for H1FOO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0016584 nucleosome positioning ISS --
GO:0044030 regulation of DNA methylation ISS --
GO:0051321 meiotic cell cycle IEA --
GO:2000737 negative regulation of stem cell differentiation ISS --
genes like me logo Genes that share ontologies with H1FOO: view

Transcripts for H1FOO Gene

mRNA/cDNA for H1FOO Gene

(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for H1FOO Gene

H1 histone family, member O, oocyte-specific:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H1FOO

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for H1FOO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for H1FOO Gene

No ASD Table

Relevant External Links for H1FOO Gene

GeneLoc Exon Structure for
H1FOO
ECgene alternative splicing isoforms for
H1FOO

Expression for H1FOO Gene

mRNA expression in normal human tissues for H1FOO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for H1FOO Gene

This gene is overexpressed in Testis (50.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for H1FOO Gene

SOURCE GeneReport for Unigene cluster for H1FOO Gene Hs.97358

mRNA Expression by UniProt/SwissProt for H1FOO Gene

Q8IZA3-H1FOO_HUMAN
Tissue specificity: Oocyte-specific.
genes like me logo Genes that share expressions with H1FOO: view

In Situ Assay Products

Orthologs for H1FOO Gene

This gene was present in the common ancestor of chordates.

Orthologs for H1FOO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H1FOO 35
  • 98.65 (n)
  • 98.55 (a)
H1FOO 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia H1FOO 35
  • 75.63 (n)
  • 60.98 (a)
H1FOO 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia H1FOO 35
  • 76.07 (n)
  • 64.26 (a)
H1FOO 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H1foo 35
  • 65.64 (n)
  • 52.22 (a)
H1foo 16
H1foo 36
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia H1FOO 36
  • 16 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia H1FOO 36
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia H1foo 35
  • 64.37 (n)
  • 50.31 (a)
zebrafish
(Danio rerio)
Actinopterygii h1m 36
  • 23 (a)
OneToOne
Species with no ortholog for H1FOO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for H1FOO Gene

ENSEMBL:
Gene Tree for H1FOO (if available)
TreeFam:
Gene Tree for H1FOO (if available)

Paralogs for H1FOO Gene

Pseudogenes.org Pseudogenes for H1FOO Gene

genes like me logo Genes that share paralogs with H1FOO: view

No data available for Paralogs for H1FOO Gene

Variants for H1FOO Gene

Sequence variations from dbSNP and Humsavar for H1FOO Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs749281 -- 129,544,679(-) GCCAC(C/G)CCCAG intron-variant
rs749282 -- 129,544,535(-) CCCCA(C/T)GCCCC intron-variant
rs1078507 -- 129,543,737(+) TGAGG(G/T)TGCAC intron-variant
rs1872110 -- 129,544,172(+) AGCGC(A/G)CCAGC intron-variant
rs1872111 -- 129,544,297(+) TGAAC(A/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for H1FOO Gene

Variant ID Type Subtype PubMed ID
dgv5254n71 CNV Loss 21882294
dgv5255n71 CNV Loss 21882294
nsv522149 CNV Loss 19592680
nsv508953 CNV Insertion 20534489

Relevant External Links for H1FOO Gene

HapMap Linkage Disequilibrium report
H1FOO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H1FOO Gene

Disorders for H1FOO Gene

(1) University of Copenhagen DISEASES for H1FOO Gene

Relevant External Links for H1FOO

Genetic Association Database (GAD)
H1FOO
genes like me logo Genes that share disorders with H1FOO: view

No data available for UniProtKB/Swiss-Prot for H1FOO Gene

Publications for H1FOO Gene

  1. Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte. (PMID: 12711322) Tanaka Y. … Yoshimura Y. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice. (PMID: 14729478) Gao S. … Latham K.E. (Dev. Biol. 2004) 3
  5. Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer. (PMID: 14729479) Teranishi T. … Yoshimura Y. (Dev. Biol. 2004) 3

Products for H1FOO Gene

Sources for H1FOO Gene

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