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Aliases & Descriptions for H1FOO
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| H1OO 3 | | MGC50807 2 | | OSH1 3 | | osH1 2, 3 |
| | | Descriptions |
|---|
| H1 histone family, member O, oocyte-specific 2 | | Oocyte-specific histone H1 2, 3 | | Oocyte-specific linker histone H1 3 |
|
| | Search outside databases for aliases for H1FOO genePrevious GC identifers: GC03P130543 GC03P130582 |
Summaries for H1FOO(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for H1FOO: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes. [provided by RefSeq] UniProtKB/Swiss-Prot: H1FOO_HUMAN, Q8IZA3Function: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity) |
Genomic Location for H1FOO
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the H1FOO gene 
Entrez Gene cytogenetic band: 3q21.3 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21.3H1FOO Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P130744:
(about GC identifiers)
Start:
|
130,744,747 bp from pter |
End:
|
130,752,894 bp from pter |
Size:
|
8,148 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000003.10 NT_005612.15
| Proteins for H1FOO
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: H1FOO_HUMAN, Q8IZA3 (See
protein sequence)Recommended Name: Histone H1oo Size: 346 amino acids; 35813 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: Q86WT7Alternative splicing: 2 isoforms: Q8IZA3-1 Q8IZA3-2 REFSEQ proteins: NP_722575.1
ENSEMBL proteins: ENSP00000319799
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for H1FOO: Assays for H1FOO: | Protein
Domains/ Families for H1FOO(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8IZA3
ProtoNet protein and cluster: Q8IZA3 1 Blocks protein family: IPB005818 Histone H1/H5
UniProtKB/Swiss-Prot: H1FOO_HUMAN, Q8IZA3Similarity: Belongs to the histone H1/H5 family | Gene Function for H1FOO
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_153833
Applied Biosystems Silencer® siRNAs for H1FOO
Sigma-Aldrich siRNA for H1FOO  Sigma-Aldrich shRNA for H1FOO  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153833                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_153833                                  untagged cDNA clones in CMV expression vector (see all 2): BC047943 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_153833
UniProtKB/Swiss-Prot: H1FOO_HUMAN, Q8IZA3Function: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity)1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for H1foo):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | About this table | Pathways & Interactions for H1FOO
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/7 Interacting proteins for H1FOO (ENSP000003197993) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
IEA | -- | | GO:0007126 | meiosis |
IEA | -- | About this table
|
Drugs & Compounds for H1FOO(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for H1FOO
|
Transcripts for H1FOO(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_153833
Sigma-Aldrich siRNA for H1FOO  Sigma-Aldrich shRNA for H1FOO  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_153833 REFSEQ mRNAs for H1FOO gene: NM_153833.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_153833               OriGene GFP tagged cDNA clone in CMV expression vector: NM_153833                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_153833                                  untagged cDNA clones in CMV expression vector (see all 2): BC047943  Additional cDNA sequence: AY158091.1 BC047943.1 2 DOTS entries: DT.99997933 DT.40118992 6 AceView cDNA sequences:AY158091 NM_153833 BC047943 BM564157 AA393036 AA412165
highest scoring ESTs for H1FOO:AY158091 BC047943 BM564157 NM_153833 AA393036 AA412165 Unigene Cluster for H1FOO: H1 histone family, member O, oocyte-specific Hs.97358 [show with all ESTs]Unigene Representative Sequence: BM564157
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000324382
|
Expression for H1FOO
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| H1FOO expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for H1FOO
1 / 2 1 probe-set matching H1FOO gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.97358 UniProtKB/Swiss-Prot: H1FOO_HUMAN, Q8IZA3Tissue specificity: Oocyte-specific |
Orthologs for H1FOO
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for H1FOO gene from 5/7 species (see all 7
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
LOC6098261 |
-- |
similar to oocyte-specific histone H1 |
76.72(n) 64.26(a) |
609826 XM_847169.1 XP_852262.1 |
chimpanzee (Pan troglodytes) |
H1FOO1 |
-- |
H1 histone family, member O, oocyte-specific |
98.65(n) 98.55(a) |
738671 XM_001144407.1 XP_001144407.1 |
cow (Bos taurus) |
H1FOO1 |
-- |
H1 histone family, member O, oocyte-specific |
74.34(n) 60.3(a) |
527400 NM_001035372.1 NP_001030449.1 |
rat (Rattus norvegicus) |
H1foo1 |
-- |
H1 histone family, member O, oocyte-specific |
64.21(n) 50(a) |
502875 XM_578376.1 XP_578376.1 |
mouse (Mus musculus) |
H1foo1, 5 |
65
|
H1 histone family, member O, oocyte-specific1, 5 |
65.53(n)1 52.05(a)1 |
1715061 NM_138311.21 NP_612184.11 AA4222245 AK1359445 (see all 14) |
About this table Species with no ortholog for H1FOO
ENSEMBL Gene Tree for H1FOO | Paralogs for H1FOO(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for H1FOO gene
- H1F02 H1FX2
|
SNPs/Variants for H1FOO(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for H1FOO (up to first 250kb)
|
Disorders & Mutations for H1FOO
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for H1FOO(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for H1FOO (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for H1FOO gene (see all 18
): |
Search for H1FOO
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing H1FOO
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing H1FOO
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H1FOO(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for H1FOO(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for H1FOO:

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