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H1FOO Gene

protein-coding   GIFtS: 47

GC03P130744
H1 histone family, member O, oocyte-specific
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
H1OO 3
MGC50807 2
OSH1 3
osH1 2, 3
Descriptions
H1 histone family, member O, oocyte-specific 2
Oocyte-specific histone H1 2, 3
Oocyte-specific linker histone H1 3
External Ids
HGNC: 184631
Entrez Gene: 1322432
UniProtKB: Q8IZA33
Ensembl: ENSG000001788047
Search outside databases for aliases for H1FOO gene

Previous GC identifers: GC03P130543 GC03P130582

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for H1FOO:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the
chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around
a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The
chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA
between the nucleosomes to form higher order chromatin structures. The protein encoded is a member
of the histone H1 family. This gene contains introns, unlike most histone genes. The protein
encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.
[provided by RefSeq]

UniProtKB/Swiss-Prot: H1FOO_HUMAN, Q8IZA3
Function: May play a key role in the control of gene expression during oogenesis and early
embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic
maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly
replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as
compared to H1c may contribute to this rapid replacement and increased instability of the
embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role
in nuclear remodeling (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the H1FOO gene  

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

H1FOO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P130744:     (about GC identifiers)

Start:
130,744,747 bp from pter
End:
130,752,894 bp from pter
Size:
8,148 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: H1FOO_HUMAN, Q8IZA3 (See protein sequence)
Recommended Name: Histone H1oo  
Size: 346 amino acids; 35813 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: Q86WT7
Alternative splicing: 2 isoforms:  Q8IZA3-1   Q8IZA3-2   

REFSEQ proteins: NP_722575.1  

ENSEMBL proteins: 
ENSP00000319799 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Histone H1)
Human Recombinant Proteins from Abnova (H1FOO)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000786 nucleosome IEA--
GO:0001674 female germ cell nucleus IEA--
GO:0005634 nucleus IEA--
GO:0005694 chromosome IEA--
GO:0005737 cytoplasm IEA--
About this table

Antibodies for H1FOO: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (Histone H1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (H1FOO)
Novus Biologicals Antibody for H1FOO

Assays for H1FOO: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro domains/families:
 IPR011991 Wing_hlx_DNA_bd
 IPR005818 Histone_H1/H5


   GeneDecks  H1FOO for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q8IZA3

ProtoNet protein and cluster: Q8IZA3

1 Blocks protein family: IPB005818 Histone H1/H5

UniProtKB/Swiss-Prot: H1FOO_HUMAN, Q8IZA3
Similarity: Belongs to the histone H1/H5 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (H1FOO)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (H1FOO)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_153833

              Applied Biosystems Silencer® siRNAs for H1FOO

              Sigma-Aldrich siRNA for H1FOO  
                     Sigma-Aldrich shRNA for H1FOO  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for H1FOO
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153833
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_153833
                                 untagged cDNA clones in CMV expression vector (see all 2): BC047943 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_153833

UniProtKB/Swiss-Prot: H1FOO_HUMAN, Q8IZA3
Function: May play a key role in the control of gene expression during oogenesis and early
embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic
maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly
replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as
compared to H1c may contribute to this rapid replacement and increased instability of the
embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role
in nuclear remodeling (By similarity)

1 MGI mutant phenotype (inferred from 1 allele(MGI details for H1foo):

normal

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Invitrogen iPath™ Online BioAtlas - Pathways for H1FOO (Maps provided by GeneGo):
 Cdc25 regulation of cell cycle
 CDC42 in cellular processes
 A2BR signaling via G-alpha-q: PRKCB/G/Q specific pathways (map 3a)
 A2B receptor: action via G-protein alpha s (map 1)

   GeneDecks  H1FOO for the pathways selected above  
About GeneDecksing

3 Millipore Pathways for H1FOO
 Histone modification
 Cell cycle Start of DNA replication in early S phase
 Cell cycle Chromosome condensation in prometaphase

   GeneDecks  H1FOO for the pathways selected above  
About GeneDecksing


5/7 Interacting proteins for H1FOO (ENSP000003197993) via UniProtKB, MINT, and/or STRING (see all 7 )
InteractantInteraction Details
GeneCardExternal ID(s)
DFFBENSP000003674543STRING (score=.899)
DPM1ENSP000003606403STRING (score=.899)
ECE1ENSP000003640283STRING (score=.899)
H1FXENSP000003296623STRING (score=.899)
HMGB2ENSP000002965033STRING (score=.899)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006334 nucleosome assembly IEA--
GO:0007126 meiosis IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for H1FOO

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (H1FOO)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (H1FOO)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_153833

              Sigma-Aldrich siRNA for H1FOO  
                     Sigma-Aldrich shRNA for H1FOO  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_153833  

REFSEQ mRNAs for H1FOO gene: 

NM_153833.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_153833  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153833
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_153833
                                 untagged cDNA clones in CMV expression vector (see all 2): BC047943 

Additional cDNA sequence: 

AY158091.1 BC047943.1 

2 DOTS entries:

DT.99997933  DT.40118992 

6 AceView cDNA sequences:

AY158091 NM_153833 BC047943 BM564157 AA393036 AA412165 

highest scoring ESTs for H1FOO:

AY158091 BC047943 BM564157 NM_153833 AA393036 AA412165 

Unigene Cluster for H1FOO:

H1 histone family, member O, oocyte-specific
Hs.97358  [show with all ESTs]
Unigene Representative Sequence: BM564157


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000324382  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

H1FOO expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for H1FOO

1 / 2

1 probe-set matching H1FOO gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1553064_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.97358

UniProtKB/Swiss-Prot: H1FOO_HUMAN, Q8IZA3
Tissue specificity: Oocyte-specific

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for H1FOO gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC6098261   -- similar to oocyte-specific histone H1 76.72(n)
64.26(a)
609826  XM_847169.1  XP_852262.1 
chimpanzee
(Pan troglodytes)
H1FOO1   -- H1 histone family, member O, oocyte-specific 98.65(n)
98.55(a)
738671  XM_001144407.1  XP_001144407.1 
cow
(Bos taurus)
H1FOO1   -- H1 histone family, member O, oocyte-specific 74.34(n)
60.3(a)
527400  NM_001035372.1  NP_001030449.1 
rat
(Rattus norvegicus)
H1foo1   -- H1 histone family, member O, oocyte-specific 64.21(n)
50(a)
502875  XM_578376.1  XP_578376.1 
mouse
(Mus musculus)
H1foo1, 5 65
H1 histone family, member O, oocyte-specific1, 5 65.53(n)1
52.05(a)1
1715061  NM_138311.21  NP_612184.11 
 AA4222245  AK1359445  (see all 14)
About this table        Species with no ortholog for H1FOO

ENSEMBL Gene Tree for H1FOO
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for H1FOO gene
H1F02  H1FX2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/73 NCBI SNPs in H1FOO are shown (see all 73 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 42)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 3 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs19054431,2
A,C,F,H130742860(+) actgcG/Atacta 1 -- ng519Minor allele frequency- A:0.39NS EA WA 492
rs37361701,2
C,F,H130752651(+) AATGGT/CGCTGC 1 G/G syn1 ese35Minor allele frequency- C:0.07EU EA WA NA 496
rs26259681,2
F,H130752735(+) GCTGCT/CCCTGC 1 A/A syn1 ese34Minor allele frequency- C:0.01EU EA WA 410
--
rs345175421,2
F130752807(-) TTTCTA/CGGGCC 1 P/P syn11Minor allele frequency- C:0.05NA 74
rs18721111,2
A,C,F,H,O130745830(+) TGAACA/GGGGAG 1 -- int18Minor allele frequency- G:0.14MN EU EA WA NA 736
rs27136171,2
A,C,F,H130748852(-) CGTGGC/GGGGTG 1 -- int13Minor allele frequency- G:0.46EA WA 298
rs10785071,2
A,C,F,H130745270(+) TGAGGG/TTGCAC 1 -- int14Minor allele frequency- T:0.11EU EA WA 418
rs26259671,2
A,C,F,H130749949(+) AGCAGG/AGAGAA 1 -- int1 trp37Minor allele frequency- A:0.41EU EA WA NA 542
rs26259661,2
A,C,F,H130749747(+) CTGGGC/TCCCCT 1 -- int18Minor allele frequency- T:0.42EU EA WA 834
rs26259561,2
A,C,F,H130747960(+) caccaG/Tcttgt 1 -- int112Minor allele frequency- T:0.44EU EA WA NA 1044
About this table

HapMap Linkage Disequilibrium images for H1FOO (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/18 PubMed articles for H1FOO gene (see all 18 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 132243 HGNC: 18463 AceView: H1FOO Ensembl:ENSG00000178804 euGenes: HUgn132243
ECgene: H1FOO H-InvDB: H1FOO
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for H1FOO:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for H1FOO-related products

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 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for H1FOO Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for H1FOO Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
(Histone H1)
 Antibodies (Histone H1)
 Search OriGene for H1FOO
 Search Tocris compounds for H1FOO




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for H1FOO

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