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Aliases & Descriptions for H1FNT
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| H1T2 1, 2 | | HANP1 1, 2, 3 |
| | | Descriptions |
|---|
| H1 histone family, member N, testis-specific 2 | | Haploid germ cell-specific nuclear protein 1 2, 3 | | Histone H1t2 3 |
|
| | Search outside databases for aliases for H1FNT gene |
Summaries for H1FNT(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: H1FNT_HUMAN, Q75WM6Function: Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity) |
Genomic Location for H1FNT
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the H1FNT gene 
Entrez Gene cytogenetic band: 12q13.11 Ensembl cytogenetic band: 12q13.11 HGNC cytogenetic band: 12q13.11H1FNT Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P047012:
(about GC identifiers)
Start:
|
47,009,030 bp from pter |
End:
|
47,010,329 bp from pter |
Size:
|
1,300 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for H1FNT
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: H1FNT_HUMAN, Q75WM6 (See
protein sequence)Recommended Name: Testis-specific H1 histone Size: 255 amino acids; 28116 Da
Subcellular location: Nucleus (By similarity). Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole (By similarity)
Caution: It is uncertain whether Met-1 or Met-22 is the initiator
Secondary accessions: Q147U8 Q5GKZ5 Q7Z694REFSEQ proteins: NP_861453.1
ENSEMBL proteins: ENSP00000334805
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: H1FNT 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for H1FNT: Assays for H1FNT: | Protein
Domains/ Families for H1FNT(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q75WM6 UniProtKB/Swiss-Prot: H1FNT_HUMAN, Q75WM6Similarity: Belongs to the histone H1/H5 family | Gene Function for H1FNT
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181788
Applied Biosystems Silencer® siRNAs for H1FNT
Sigma-Aldrich siRNA for H1FNT  Sigma-Aldrich shRNA for H1FNT  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_181788                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_181788                                  untagged cDNA clone in CMV expression vector: NM_181788 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_181788
UniProtKB/Swiss-Prot: H1FNT_HUMAN, Q75WM6Function: Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity)1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for H1fnt):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for H1FNT
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for H1FNT (ENSP000003348053) via UniProtKB, MINT, and/or STRINGAbout this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for H1FNT(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for H1FNT
|
Transcripts for H1FNT(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181788
Sigma-Aldrich siRNA for H1FNT  Sigma-Aldrich shRNA for H1FNT  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_181788 REFSEQ mRNAs for H1FNT gene: NM_181788.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_181788               OriGene GFP tagged cDNA clone in CMV expression vector: NM_181788                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_181788                                  untagged cDNA clone in CMV expression vector: NM_181788  Additional cDNA sequence: AB121028.2 AY302593.1 BC118635.1 BC119787.1 1 DOTS entry: DT.40227313 17 AceView cDNA sequences:AI650408 BE502688 AI990167 BF431650 AY302593 AI808336 BE466599 NM_181788 AI671196 AI624717 AB121028 AW665295 BI825819 AI142283 AW013835 BX335317 AA903784
highest scoring ESTs for H1FNT:AI142283 AI808336 AA903784 AB121028 AI624717 AI650408 AI671196 AI990167 AW013835 AW665295 Unigene Cluster for H1FNT: H1 histone family, member N, testis-specific Hs.155833 [show with all ESTs]Unigene Representative Sequence: AY302593
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000335017
|
Expression for H1FNT
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| H1FNT expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for H1FNT
1 / 2 / 3 6 probe-sets matching H1FNT gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCTGAGGCGC
SOURCE GeneReport for Unigene cluster: Hs.155833 UniProtKB/Swiss-Prot: H1FNT_HUMAN, Q75WM6Tissue specificity: Testis-specific |
Orthologs for H1FNT
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for H1FNT gene from 5 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
LOC6093031 |
-- |
similar to histone H1 variant |
73.61(n) 60(a) |
609303 XM_846542.1 XP_851635.1 |
chimpanzee (Pan troglodytes) |
H1FNT1 |
-- |
H1 histone family, member N, testis-specific |
99.08(n) 97.65(a) |
743587 XM_001160555.1 XP_001160555.1 |
cow (Bos taurus) |
H1FNT1 |
-- |
H1 histone family, member N, testis-specific |
72.92(n) 59.37(a) |
617351 XM_869593.2 XP_874686.1 |
rat (Rattus norvegicus) |
H1fnt1 |
-- |
H1 histone family, member N, testis-specific |
61.24(n) 52.49(a) |
500928 NM_001024356.1 NP_001019527.1 |
mouse (Mus musculus) |
H1fnt1, 5 |
155
|
H1 histone family, member N, testis-specific1, 5 |
58.56(n)1 50.45(a)1 |
700691 NM_027304.11 NP_081580.11 AB0162735 AI0376355 (see all 9) |
About this table Species with no ortholog for H1FNT
ENSEMBL Gene Tree for H1FNT | Paralogs for H1FNT(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for H1FNT(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for H1FNT (up to first 250kb)
|
Disorders & Mutations for H1FNT
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for H1FNT(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for H1FNT (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for H1FNT gene: |
Search for H1FNT
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing H1FNT
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing H1FNT
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H1FNT(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for H1FNT(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for H1FNT:

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Incremental update: 13 Oct 2009
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