H1FNT Gene
protein-coding GIFtS: 37
GCID: GC12P048722
|
|
H1 histone family, member N, testis-specific
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Aliases
for H1FNT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| H1 Histone Family, Member N, Testis-Specific1 2 | | HANP11 2 3 | | H1T21 2 | | Haploid Germ Cell-Specific Nuclear Protein 12 3 | | Histone H1t22 3 | | Testis-Specific H1 Histone2 |
Export aliases for H1FNT gene to outside databasesPrevious GC identifers: GC12P047012 GC12P045755 |
Summaries
for H1FNT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: H1FNT_HUMAN, Q75WM6Function: Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNAcondensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of spermchromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATPand protamine-1 (By similarity)
|
Genomic Views
for H1FNT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the H1FNT gene promoter:
GR GR-beta NF-kappaB C/EBPalpha E47 HEN1 NF-kappaB2 GR-alpha NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for H1FNT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H1FNT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.11 Ensembl cytogenetic band: 12q13.11 HGNC cytogenetic band: 12q13.11H1FNT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P048722: view genomic region
(about GC identifiers)
Start:
|
48,722,763 bp from pter |
End:
|
48,724,062 bp from pter |
Size:
|
1,300 bases |
Orientation:
|
plus strand |
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Proteins
for H1FNT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: H1FNT_HUMAN, Q75WM6 (See
protein sequence)Recommended Name: Testis-specific H1 histone Size: 255 amino acids; 28116 Da
Subcellular location: Nucleus (By similarity). Chromosome (By similarity). Note=In round and elongating spermatids,specifically localizes to a chromatin domain at the apical pole (By similarity)
Caution: It is uncertain whether Met-1 or Met-22 is the initiator
Sequence caution: Sequence=BAD13382.2; Type=Erroneous initiation;
Secondary accessions: Q147U8 Q5GKZ5 Q7Z694Explore the universe of human proteins at neXtProt for H1FNT: NX_Q75WM6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q75WM6
H1FNT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_861453.1
ENSEMBL proteins: ENSP00000334805
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
H1FNT for ontologies About GeneDecksing
H1FNT Antibody Products:
Assay Products for H1FNT: |
Protein
Domains /
Families
for H1FNT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q75WM6 UniProtKB/Swiss-Prot: H1FNT_HUMAN, Q75WM6Similarity: Belongs to the histone H1/H5 family |
Function
for H1FNT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: H1FNT_HUMAN, Q75WM6Function: Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNAcondensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of spermchromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATPand protamine-1 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H1FNT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H1FNT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: H1FNT (NM_181788) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for H1FNT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H1FNT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H1FNT |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
H1FNT for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for H1FNT: H1fnttm1Idvd H1fnttm1Yoni
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for H1fnt):
H1FNT for phenotypes About GeneDecksing
|
Pathways & Interactions
for H1FNT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H1FNT
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
H1FNT for ontologies About GeneDecksing
|
Drugs & Compounds
for H1FNT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for H1FNT
Search CenterWatch for drugs/clinical trials and news about H1FNT
|
Transcripts
for H1FNT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for H1FNT gene: NM_181788.1 Unigene Cluster for H1FNT: H1 histone family, member N, testis-specific Hs.155833 [show with all ESTs]Unigene Representative Sequence: AY3025931 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000335017(uc001rrm.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H1FNT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H1FNT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: H1FNT (NM_181788) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for H1FNT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H1FNT |
Additional cDNA sequence: AB121028.2 AY302593.1 BC118635.1 BC119787.1 1 DOTS entry: DT.40227313 17 AceView cDNA sequences: AI808336 AI671196 AI990167 AI624717 AI650408 BF431650 NM_181788 BE502688 BE466599 AY302593 AW665295 BI825819 AB121028 BX335317 AI142283 AW013835 AA903784
GeneLoc Exon Structure
|
Expression
for H1FNT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| H1FNT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGAGGCGC
About this image
See H1FNT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for H1FNT
SOURCE GeneReport for Unigene cluster: Hs.155833
UniProtKB/Swiss-Prot: H1FNT_HUMAN, Q75WM6Tissue specificity: Testis-specific
SABiosciences Custom PCR Arrays for H1FNT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for H1FNT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat H1FNT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H1FNT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H1FNT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H1FNT |
Orthologs
for H1FNT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for H1FNT gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
H1fnt1 , 5 |
H1 histone family, member N, testis-specific1, 5 |
58.56(n)1
50.45(a)1 |
|
15 (54.26 cM)5
700691 NM_027304.21 NP_081580.21
982559825 |
ENSEMBL Gene Tree for H1FNT (if available)
TreeFam Gene Tree for H1FNT (if available) |
Paralogs
for H1FNT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for H1FNT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for H1FNT (48722763 - 48724062 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for H1FNT
4 CNVs: 30600 2983 8729 3888 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H1FNT |
|
Disorders
/ Diseases
for H1FNT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for H1FNT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for H1FNT gene integrated from 9 sources:
(articles sorted by number of sources associating them with H1FNT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. (PubMed id 15710904)1, 2, 3 Martianov I....Davidson I. (2005)
- Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein. (PubMed id 16533358)1, 2, 9 Tanaka H.... Nishimune Y. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- HANP1/H1T2, a novel histone H1-like protein involved in nuclear formation and sperm fertility. (PubMed id 16055721)1 Tanaka H....Nishimune Y. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- mRNA levels of the differentiation-associated linker histone variant H1 zero in mitotically active and postmitotic senescent human diploid fibroblast cell populations. (PubMed id 11672986)9 Tsapali D.S....Sourlingas T.G. (2001)
|
External Searches for H1FNT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing H1FNT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing H1FNT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H1FNT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for H1FNT | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for H1FNT gene:
Search GeneIP for patents involving H1FNT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for H1FNT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | Search Tocris compounds for H1FNT |
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 | | | H1FNT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H1FNT |
|  |  |  | | | | Search ThermoFisher Antibodies for H1FNT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H1FNT |
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