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Aliases for H1FNT Gene

Aliases for H1FNT Gene

  • H1 Histone Family Member N, Testis Specific 2 3 5
  • H1 Histone Family, Member N, Testis-Specific 2 3
  • Haploid Germ Cell-Specific Nuclear Protein 1 3 4
  • Histone H1t2 3 4
  • HANP1 3 4
  • Testis Secretory Sperm-Binding Protein Li 223n 3
  • H1.7 3
  • H1T2 3

External Ids for H1FNT Gene

Previous GeneCards Identifiers for H1FNT Gene

  • GC12P047012
  • GC12P048722
  • GC12P045755

Summaries for H1FNT Gene

Entrez Gene Summary for H1FNT Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]

GeneCards Summary for H1FNT Gene

H1FNT (H1 Histone Family Member N, Testis Specific) is a Protein Coding gene.

UniProtKB/Swiss-Prot for H1FNT Gene

  • Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H1FNT Gene

Genomics for H1FNT Gene

Regulatory Elements for H1FNT Gene

Enhancers for H1FNT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around H1FNT on UCSC Golden Path with GeneCards custom track

Genomic Location for H1FNT Gene

Chromosome:
12
Start:
48,328,980 bp from pter
End:
48,330,279 bp from pter
Size:
1,300 bases
Orientation:
Plus strand

Genomic View for H1FNT Gene

Genes around H1FNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H1FNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H1FNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1FNT Gene

Proteins for H1FNT Gene

  • Protein details for H1FNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75WM6-H1FNT_HUMAN
    Recommended name:
    Testis-specific H1 histone
    Protein Accession:
    Q75WM6
    Secondary Accessions:
    • Q147U8
    • Q5GKZ5
    • Q7Z694

    Protein attributes for H1FNT Gene

    Size:
    255 amino acids
    Molecular mass:
    28116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD13382.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for H1FNT Gene

Proteomics data for H1FNT Gene at MOPED

Post-translational modifications for H1FNT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for H1FNT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for H1FNT

No data available for DME Specific Peptides for H1FNT Gene

Domains & Families for H1FNT Gene

Gene Families for H1FNT Gene

Protein Domains for H1FNT Gene

ProtoNet:

Suggested Antigen Peptide Sequences for H1FNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q75WM6

UniProtKB/Swiss-Prot:

H1FNT_HUMAN :
  • Belongs to the histone H1/H5 family.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1FNT: view

Function for H1FNT Gene

Molecular function for H1FNT Gene

UniProtKB/Swiss-Prot Function:
Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity).

Gene Ontology (GO) - Molecular Function for H1FNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with H1FNT: view
genes like me logo Genes that share phenotypes with H1FNT: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H1FNT Gene

Localization for H1FNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1FNT Gene

Nucleus. Chromosome. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for H1FNT Gene COMPARTMENTS Subcellular localization image for H1FNT gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for H1FNT Gene

Pathways & Interactions for H1FNT Gene

SuperPathways for H1FNT Gene

No Data Available

Interacting Proteins for H1FNT Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000334805%0d%0a9606.ENSP00000320147%0d%0a
Selected Interacting proteins: ENSP00000334805 for H1FNT Gene via STRING

Symbol External ID(s) Details
EZH2

Gene Ontology (GO) - Biological Process for H1FNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007290 spermatid nucleus elongation IEA,ISS 15710904
GO:0030261 chromosome condensation IEA --
genes like me logo Genes that share ontologies with H1FNT: view

No data available for Pathways by source and SIGNOR curated interactions for H1FNT Gene

Drugs & Compounds for H1FNT Gene

No Compound Related Data Available

Transcripts for H1FNT Gene

mRNA/cDNA for H1FNT Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for H1FNT Gene

H1 histone family, member N, testis-specific:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for H1FNT Gene

No ASD Table

Relevant External Links for H1FNT Gene

GeneLoc Exon Structure for
H1FNT
ECgene alternative splicing isoforms for
H1FNT

Expression for H1FNT Gene

mRNA expression in normal human tissues for H1FNT Gene

mRNA differential expression in normal tissues according to GTEx for H1FNT Gene

This gene is overexpressed in Testis (x49.2).

Protein differential expression in normal tissues from HIPED for H1FNT Gene

This gene is overexpressed in Esophagus (39.2), Pancreatic juice (8.1), Peripheral blood mononuclear cells (6.9), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for H1FNT Gene



SOURCE GeneReport for Unigene cluster for H1FNT Gene Hs.155833

mRNA Expression by UniProt/SwissProt for H1FNT Gene

Q75WM6-H1FNT_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with H1FNT: view

Protein tissue co-expression partners for H1FNT Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for H1FNT Gene

Orthologs for H1FNT Gene

This gene was present in the common ancestor of mammals.

Orthologs for H1FNT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia H1FNT 35
  • 72.15 (n)
  • 57.14 (a)
dog
(Canis familiaris)
Mammalia LOC609303 35
  • 73.44 (n)
  • 59.75 (a)
H1FNT 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia H1FNT 35
  • 99.08 (n)
  • 97.65 (a)
H1FNT 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H1fnt 36
  • 32 (a)
OneToOne
Species with no ortholog for H1FNT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for H1FNT Gene

ENSEMBL:
Gene Tree for H1FNT (if available)
TreeFam:
Gene Tree for H1FNT (if available)

Paralogs for H1FNT Gene

No data available for Paralogs for H1FNT Gene

Variants for H1FNT Gene

Sequence variations from dbSNP and Humsavar for H1FNT Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2732441 - 48,329,541(-) GTTTC(C/G)GAGCT reference, missense
VAR_044372 -
VAR_044373 -
rs1471997 -, - 48,329,812(-) CGTTC(C/T)GTCTC reference, missense
rs2291483 - 48,330,001(-) GCTTG(A/G)AGCTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for H1FNT Gene

Variant ID Type Subtype PubMed ID
dgv509e1 CNV Complex 17122850
nsv8971 CNV Gain+Loss 18304495
esv34439 CNV Gain 17911159
dgv510e1 CNV Complex 17122850
nsv832402 CNV Gain 17160897
nsv826362 CNV Gain 20364138
nsv437752 CNV Loss 16327808

Variation tolerance for H1FNT Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for H1FNT Gene

Disorders for H1FNT Gene

Relevant External Links for H1FNT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
H1FNT

No disorders were found for H1FNT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for H1FNT Gene

Publications for H1FNT Gene

  1. Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. (PMID: 15710904) Martianov I. … Davidson I. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 67
  2. Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein. (PMID: 16533358) Tanaka H. … Nishimune Y. (Int. J. Androl. 2006) 3 23
  3. Every amino acid matters: essential contributions of histone variants to mammalian development and disease. (PMID: 24614311) Maze I. … Allis C.D. (Nat. Rev. Genet. 2014) 3
  4. Histone variants: key players of chromatin. (PMID: 24781148) Biterge B. … Schneider R. (Cell Tissue Res. 2014) 3
  5. A unified phylogeny-based nomenclature for histone variants. (PMID: 22650316) Talbert P.B. … Henikoff S. (Epigenetics Chromatin 2012) 3

Products for H1FNT Gene

Sources for H1FNT Gene

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