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Aliases for H1FNT Gene

Aliases for H1FNT Gene

  • H1 Histone Family Member N, Testis Specific 2 3 5
  • Haploid Germ Cell-Specific Nuclear Protein 1 3 4
  • Histone H1t2 3 4
  • HANP1 3 4
  • Testis Secretory Sperm-Binding Protein Li 223n 3
  • H1 Histone Family, Member N, Testis-Specific 2
  • Testis-Specific H1 Histone 3
  • H1.7 3
  • H1T2 3

External Ids for H1FNT Gene

Previous GeneCards Identifiers for H1FNT Gene

  • GC12P047012
  • GC12P048722
  • GC12P045755

Summaries for H1FNT Gene

Entrez Gene Summary for H1FNT Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]

GeneCards Summary for H1FNT Gene

H1FNT (H1 Histone Family Member N, Testis Specific) is a Protein Coding gene.

UniProtKB/Swiss-Prot for H1FNT Gene

  • Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity).

Additional gene information for H1FNT Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H1FNT Gene

Genomics for H1FNT Gene

Regulatory Elements for H1FNT Gene

Enhancers for H1FNT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H048307 0.6 FANTOM5 56.9 -21.5 -21479 0.1 TFDP1 PKNOX1 IRF2 H1FNT C12orf54 PFKM SENP1 LOC105369753 ENSG00000275228
GH12H049055 1.7 FANTOM5 ENCODE dbSUPER 12.7 +729.5 729523 6.7 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZFP41 MEF2D DDX23 LOC390314 LMBR1L CCNT1 KANSL2 KMT2D SENP1 LOC100422296 PRPF40B OR5BK1P
GH12H047831 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -494.7 -494653 5 HDGF ATF1 TCF12 GATA2 ATF7 RUNX3 MCM3 SMARCA4 ZNF184 GLIS1 LOC390314 SENP1 LOC102725258 CCNT1 HDAC7 CCDC184 H1FNT KANSL2 RPAP3 CACNB3
GH12H048156 1.3 ENCODE dbSUPER 15.7 -171.5 -171526 2.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 DEK SP3 SENP1 KMT2D DDX23 PFKM RPL37P19 CCNT1 ZNF641 H1FNT ASB8 KANSL2
GH12H048104 1.2 ENCODE 15.9 -222.7 -222691 4.1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SENP1 CCNT1 KMT2D KANSL2 DDX23 RPL37P19 RPAP3 LOC390314 PRKAG1 ZNF641
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around H1FNT on UCSC Golden Path with GeneCards custom track

Genomic Locations for H1FNT Gene

Genomic Locations for H1FNT Gene
chr12:48,328,980-48,330,279
(GRCh38/hg38)
Size:
1,300 bases
Orientation:
Plus strand
chr12:48,722,763-48,724,062
(GRCh37/hg19)

Genomic View for H1FNT Gene

Genes around H1FNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H1FNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H1FNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1FNT Gene

Proteins for H1FNT Gene

  • Protein details for H1FNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75WM6-H1FNT_HUMAN
    Recommended name:
    Testis-specific H1 histone
    Protein Accession:
    Q75WM6
    Secondary Accessions:
    • Q147U8
    • Q5GKZ5
    • Q7Z694

    Protein attributes for H1FNT Gene

    Size:
    255 amino acids
    Molecular mass:
    28116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD13382.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for H1FNT Gene

Post-translational modifications for H1FNT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for H1FNT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H1FNT Gene

Domains & Families for H1FNT Gene

Gene Families for H1FNT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for H1FNT Gene

ProtoNet:

Suggested Antigen Peptide Sequences for H1FNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q75WM6

UniProtKB/Swiss-Prot:

H1FNT_HUMAN :
  • Belongs to the histone H1/H5 family.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1FNT: view

Function for H1FNT Gene

Molecular function for H1FNT Gene

UniProtKB/Swiss-Prot Function:
Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity).

Phenotypes From GWAS Catalog for H1FNT Gene

Gene Ontology (GO) - Molecular Function for H1FNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with H1FNT: view
genes like me logo Genes that share phenotypes with H1FNT: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for H1FNT Gene

Localization for H1FNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1FNT Gene

Nucleus. Chromosome. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H1FNT gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for H1FNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISS 15710904
GO:0005634 nucleus IEA,IDA 21630459
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with H1FNT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for H1FNT Gene

Pathways & Interactions for H1FNT Gene

SuperPathways for H1FNT Gene

No Data Available

Interacting Proteins for H1FNT Gene

Gene Ontology (GO) - Biological Process for H1FNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007290 spermatid nucleus elongation ISS 15710904
GO:0030154 cell differentiation IEA --
GO:0030261 chromosome condensation IEA --
genes like me logo Genes that share ontologies with H1FNT: view

No data available for Pathways by source and SIGNOR curated interactions for H1FNT Gene

Drugs & Compounds for H1FNT Gene

No Compound Related Data Available

Transcripts for H1FNT Gene

mRNA/cDNA for H1FNT Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for H1FNT Gene

H1 histone family, member N, testis-specific:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for H1FNT Gene

No ASD Table

Relevant External Links for H1FNT Gene

GeneLoc Exon Structure for
H1FNT
ECgene alternative splicing isoforms for
H1FNT

Expression for H1FNT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for H1FNT Gene

mRNA differential expression in normal tissues according to GTEx for H1FNT Gene

This gene is overexpressed in Testis (x49.2).

Protein differential expression in normal tissues from HIPED for H1FNT Gene

This gene is overexpressed in Esophagus (39.2), Pancreatic juice (8.1), Peripheral blood mononuclear cells (6.9), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for H1FNT Gene



Protein tissue co-expression partners for H1FNT Gene

NURSA nuclear receptor signaling pathways regulating expression of H1FNT Gene:

H1FNT

SOURCE GeneReport for Unigene cluster for H1FNT Gene:

Hs.155833

mRNA Expression by UniProt/SwissProt for H1FNT Gene:

Q75WM6-H1FNT_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with H1FNT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for H1FNT Gene

Orthologs for H1FNT Gene

This gene was present in the common ancestor of mammals.

Orthologs for H1FNT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H1FNT 33 34
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia LOC609303 33
  • 73.44 (n)
H1FNT 34
  • 56 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC784038 33
  • 72.15 (n)
mouse
(Mus musculus)
Mammalia H1fnt 34
  • 32 (a)
OneToOne
Species where no ortholog for H1FNT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for H1FNT Gene

ENSEMBL:
Gene Tree for H1FNT (if available)
TreeFam:
Gene Tree for H1FNT (if available)

Paralogs for H1FNT Gene

No data available for Paralogs for H1FNT Gene

Variants for H1FNT Gene

Sequence variations from dbSNP and Humsavar for H1FNT Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000417144 -- 48,330,441(+) TAACA(A/G)GTGTT downstream-variant-500B
rs1000650905 -- 48,328,320(+) TAAGG(A/G)ATTTG upstream-variant-2KB
rs1001919887 -- 48,329,736(+) CCCCA(C/G)CCGCG reference, missense
rs1003343737 -- 48,328,407(+) TAAAA(A/C)ATATT upstream-variant-2KB
rs1003443892 -- 48,328,088(+) GGACA(C/T)AGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for H1FNT Gene

Variant ID Type Subtype PubMed ID
nsv8971 CNV gain+loss 18304495
nsv832402 CNV gain 17160897
nsv826362 CNV gain 20364138
nsv437752 CNV loss 16327808
nsv1160031 CNV deletion 26073780
esv3629436 CNV gain 21293372
esv34439 CNV gain 17911159
esv2759898 CNV gain+loss 17122850

Variation tolerance for H1FNT Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for H1FNT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H1FNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H1FNT Gene

Disorders for H1FNT Gene

Relevant External Links for H1FNT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
H1FNT

No disorders were found for H1FNT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for H1FNT Gene

Publications for H1FNT Gene

  1. Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein. (PMID: 16533358) Tanaka H … Nishimune Y (International journal of andrology 2006) 3 4 22 60
  2. Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. (PMID: 15710904) Martianov I … Davidson I (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Role of H1 linker histones in mammalian development and stem cell differentiation. (PMID: 26689747) Pan C … Fan Y (Biochimica et biophysica acta 2016) 3 60
  5. Histone variants: key players of chromatin. (PMID: 24781148) Biterge B … Schneider R (Cell and tissue research 2014) 3 60

Products for H1FNT Gene

Sources for H1FNT Gene

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