Aliases for H1F0 Gene
External Ids for H1F0 Gene
Previous HGNC Symbols for H1F0 Gene
Previous GeneCards Identifiers for H1F0 Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
GeneCards Summary for H1F0 Gene
H1F0 (H1 Histone Family Member 0) is a Protein Coding gene. Diseases associated with H1F0 include Retinal Cancer and Deafness, Autosomal Dominant 25. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and E2F mediated regulation of DNA replication. GO annotations related to this gene include poly(A) RNA binding and chromatin DNA binding.
UniProtKB/Swiss-Prot for H1F0 Gene
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.