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Aliases & Descriptions for H1F0
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| H10 1, 2 | | H1FV 2, 3, 5 | | MGC5241 2 | | OTTHUMP00000028818 2 |
| | | Descriptions |
|---|
| H1 histone family, member 0 2 | | H1.0, H1(0), H1-0 2 | | Histone H1' 3 | | Histone H1(0) 3 |
|
| | Search outside databases for aliases for H1F0 genePrevious GC identifers: GC22P034815 GC22P036444 |
Summaries for H1F0(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for H1F0: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H1 family. [provided by RefSeq] UniProtKB/Swiss-Prot: H10_HUMAN, P07305Function: Histones H1 are necessary for the condensation of nucleosome chains into higher order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division |
Genomic Location for H1F0
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the H1F0 gene 
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1H1F0 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P036525:
(about GC identifiers)
Start:
|
36,531,060 bp from pter |
End:
|
36,533,389 bp from pter |
Size:
|
2,330 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000022.9 NT_011520.11
| Proteins for H1F0
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: H10_HUMAN, P07305 (See
protein sequence)Recommended Name: Histone H1.0 Size: 194 amino acids; 20863 Da
Subcellular location: Nucleus. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes
Rna editing: Modified_positions=Not_applicable; Note=Partially edited. In approximately 3.6% of the mRNA molecules, a new initiator methionine is created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 99 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 12-21; 22-33; 37-47; 48-67; 68-83; 84-94 and 97-113. The RNA edited version is called ET-H1.0
Secondary accessions: Q6FG88 Q8N6R3Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated on Ser-17 in RNA edited version1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005309.1
ENSEMBL proteins: ENSP00000344504
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for H1F0: Assays for H1F0: | Protein
Domains/ Families for H1F0(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P07305
ProtoNet protein and cluster: P07305 3 Blocks protein families: IPB003216 Linker histone IPB005818 Histone H1/H5 IPB005819 Histone H5 signature
UniProtKB/Swiss-Prot: H10_HUMAN, P07305Similarity: Belongs to the histone H1/H5 family | Gene Function for H1F0
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005318
Applied Biosystems Silencer® siRNAs for H1F0
Sigma-Aldrich siRNA for H1F0  Sigma-Aldrich shRNA for H1F0  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005318                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005318                                  untagged cDNA clones in CMV expression vector (see all 3): AK091372 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: AK091372
UniProtKB/Swiss-Prot: H10_HUMAN, P07305Function: Histones H1 are necessary for the condensation of nucleosome chains into higher order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell divisionInduction: Both the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA edited version is induced by DTT, vinblastine or TNF (at protein level)Genatlas biochemistry entry for H1F0:linker histone 1 family 0,replacement subtype,replication-independent,involved in basal repression of gene expression6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for H1f0):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | About this table | Pathways & Interactions for H1F0
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/8 Interacting proteins for H1F0 (ENSP000003445043 P073052) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
IEA | -- | About this table
|
Drugs & Compounds for H1F0(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for H1F0 1 Novoseek chemical compound relationship for H1F0 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atp |
23.16 |
2 |
1743293 (1), 16888724 (1) |
About this table
|
Transcripts for H1F0(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005318
Sigma-Aldrich siRNA for H1F0  Sigma-Aldrich shRNA for H1F0  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005318 REFSEQ mRNAs for H1F0 gene: NM_005318.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005318               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005318                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005318                                  untagged cDNA clones in CMV expression vector (see all 3): AK091372  Additional cDNA sequence: AK091372.1 AK299209.1 AK312583.1 BC000145.1 BC029046.1 CR456502.1 CR542220.1 CR591666.1 CR591712.1 CR594003.1 CR596843.1 CR597945.1 CR598601.1 CR598888.1 CR601737.1 CR604452.1 CR604812.1 CR606708.1 CR606842.1 CR606855.1 CR609515.1 CR610156.1 CR613392.1 CR615517.1 CR615993.1 CR617321.1 CR619372.1 CR620114.1 CR623269.1 CR623443.1 CR623479.1 CR624468.1 24/29 DOTS entries (see all 29
): DT.100654599 DT.450368 DT.100673364 DT.100890518 DT.100890489 DT.100890486 DT.100890506 DT.100890511 DT.91999969 DT.100038438 DT.120668854 DT.100890520 DT.120668817 DT.91999780 DT.100803811 DT.120668865 DT.120668875 DT.100890477 DT.100890503 DT.100890522 DT.120668851 DT.100776592 DT.100890485 DT.100890491 24/365 AceView cDNA sequences (see all 365
):CR591712 CD620237 CR613392 CR620114 AL541905 CR598601 AA337113 CR601737 CA425534 BX422426 CR610156 CR456502 CR617321 CR606708 CD620225 CR596843 BU689052 BM679144 CB529733 CR623269 CK429953 CD675060 CD721775 CR619372
highest scoring ESTs for H1F0:AA127567 AA171412 AA206831 AA214079 AA337588 AA337603 AA378094 AA477272 AA477273 AA489401 Unigene Cluster for H1F0: H1 histone family, member 0 Hs.715673 [show with all ESTs]Unigene Representative Sequence: NM_005318
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for H1F0
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | · | 2h | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for H1F0
1 Ensembl transcript including schematic representation: ENST00000340857
|
Expression for H1F0
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| H1F0 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for H1F0
1 / 2 / 3 5 probe-sets matching H1F0 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGTGTGTTTG
SOURCE GeneReport for Unigene cluster: Hs.715673
Expression variation in blood from EXPOLDB for H1F0 |
Orthologs for H1F0
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for H1F0 gene from 5/15 species (see all 15
)
About this table Species with no ortholog for H1F0
ENSEMBL Gene Tree for H1F0 | Paralogs for H1F0(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for H1F0 gene
- H1FOO2 H1FX2
|
SNPs/Variants for H1F0(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for H1F0 (up to first 250kb)
|
Disorders & Mutations for H1F0
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 142708
1 PharmGKB disease relationship for H1F0 geneAbout this table
|
Medical News for H1F0(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for H1F0 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/28 PubMed articles for H1F0 gene (see all 28
):- Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene. (PubMed id 3084796)2, 3, 4 Doenecke D. and Tonjes R. (1986)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)3, 4 Collins J.E.... Dunham I. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)3, 4 Dunham I....O'Brien K.P. (1999)
- The microheterogeneity of the mammalian H1(0) histone. Evidence for an age-dependent deamidation. (PubMed id 9582379)3, 4 Lindner H.... Helliger W. (1998)
- Evidence for insertional RNA editing in humans. (PubMed id 18993075)4 Zougman A.... Wisniewski J.R. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)4 Matsuoka S.... Elledge S.J. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
|
Search for H1F0
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing H1F0
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing H1F0
(According to HUGE)
About This Section
| -- |
Specialized Databases showing H1F0(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Histone_H1 |
|
| | | About This Section
| --
| Services for H1F0(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for H1F0:

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Incremental update: 13 Oct 2009
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