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Aliases for H1F0 Gene

Aliases for H1F0 Gene

  • H1 Histone Family Member 0 2 3 5
  • H1 Histone Family, Member 0 2 3
  • Histone H1(0) 3 4
  • Histone H1 3 4
  • H1FV 3 4
  • H1.0, H1(0), H1-0 3
  • H1(0) 2
  • H1.0 2
  • H1-0 2
  • H10 3

External Ids for H1F0 Gene

Previous HGNC Symbols for H1F0 Gene

  • H1FV

Previous GeneCards Identifiers for H1F0 Gene

  • GC22P034815
  • GC22P036444
  • GC22P036525
  • GC22P038201
  • GC22P021168

Summaries for H1F0 Gene

Entrez Gene Summary for H1F0 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

GeneCards Summary for H1F0 Gene

H1F0 (H1 Histone Family Member 0) is a Protein Coding gene. Diseases associated with H1F0 include Retinal Cancer and Sensory System Cancer. Among its related pathways are Packaging Of Telomere Ends and Activation of DNA fragmentation factor. GO annotations related to this gene include poly(A) RNA binding and chromatin DNA binding.

UniProtKB/Swiss-Prot for H1F0 Gene

  • Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H1F0 Gene

Genomics for H1F0 Gene

Regulatory Elements for H1F0 Gene

Enhancers for H1F0 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around H1F0 on UCSC Golden Path with GeneCards custom track

Promoters for H1F0 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around H1F0 on UCSC Golden Path with GeneCards custom track

Genomic Location for H1F0 Gene

Chromosome:
22
Start:
37,805,093 bp from pter
End:
37,807,436 bp from pter
Size:
2,344 bases
Orientation:
Plus strand

Genomic View for H1F0 Gene

Genes around H1F0 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H1F0 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H1F0 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1F0 Gene

Proteins for H1F0 Gene

  • Protein details for H1F0 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07305-H10_HUMAN
    Recommended name:
    Histone H1.0
    Protein Accession:
    P07305
    Secondary Accessions:
    • B2R6I0
    • B4DRD6
    • Q6FG88
    • Q8N6R3

    Protein attributes for H1F0 Gene

    Size:
    194 amino acids
    Molecular mass:
    20863 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for H1F0 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for H1F0 Gene

Proteomics data for H1F0 Gene at MOPED

Post-translational modifications for H1F0 Gene

Other Protein References for H1F0 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H1F0 Gene

Domains & Families for H1F0 Gene

Gene Families for H1F0 Gene

Suggested Antigen Peptide Sequences for H1F0 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07305

UniProtKB/Swiss-Prot:

H10_HUMAN :
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
  • Belongs to the histone H1/H5 family.
Domain:
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1F0: view

Function for H1F0 Gene

Molecular function for H1F0 Gene

GENATLAS Biochemistry:
linker histone 1 family 0,replacement subtype,replication-independent,involved in basal repression of gene expression
UniProtKB/Swiss-Prot Function:
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
UniProtKB/Swiss-Prot Induction:
Both the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA edited version is induced by DTT, vinblastine or TNF (at protein level).

Gene Ontology (GO) - Molecular Function for H1F0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031490 chromatin DNA binding IDA 15911621
genes like me logo Genes that share ontologies with H1F0: view
genes like me logo Genes that share phenotypes with H1F0: view

Animal Models for H1F0 Gene

MGI Knock Outs for H1F0:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for H1F0 Gene

Localization for H1F0 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1F0 Gene

Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for H1F0 Gene COMPARTMENTS Subcellular localization image for H1F0 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for H1F0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0005719 nuclear euchromatin IDA 15911621
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with H1F0: view

Pathways & Interactions for H1F0 Gene

genes like me logo Genes that share pathways with H1F0: view

Pathways by source for H1F0 Gene

Gene Ontology (GO) - Biological Process for H1F0 Gene

None

No data available for SIGNOR curated interactions for H1F0 Gene

Drugs & Compounds for H1F0 Gene

(1) Drugs for H1F0 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with H1F0: view

Transcripts for H1F0 Gene

mRNA/cDNA for H1F0 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(365) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for H1F0 Gene

H1 histone family, member 0:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for H1F0 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h
SP1: - -
SP2: - -
SP3: -

Relevant External Links for H1F0 Gene

GeneLoc Exon Structure for
H1F0
ECgene alternative splicing isoforms for
H1F0

Expression for H1F0 Gene

mRNA expression in normal human tissues for H1F0 Gene

Protein differential expression in normal tissues from HIPED for H1F0 Gene

This gene is overexpressed in Uterus (8.0) and Fetal gut (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for H1F0 Gene



SOURCE GeneReport for Unigene cluster for H1F0 Gene Hs.745024

genes like me logo Genes that share expression patterns with H1F0: view

Protein tissue co-expression partners for H1F0 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for H1F0 Gene

Orthologs for H1F0 Gene

This gene was present in the common ancestor of chordates.

Orthologs for H1F0 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia H1f0 35
  • 91.73 (n)
  • 96.45 (a)
H1f0 16
H1f0 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC743278 35
  • 98.46 (n)
  • 99.4 (a)
H1F0 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia H1F0 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves H1F0 36
  • 67 (a)
OneToMany
H1F0 36
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4764 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398662 35
zebrafish
(Danio rerio)
Actinopterygii wufb23b02 35
h1f0 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10060 35
Species with no ortholog for H1F0:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for H1F0 Gene

ENSEMBL:
Gene Tree for H1F0 (if available)
TreeFam:
Gene Tree for H1F0 (if available)

Paralogs for H1F0 Gene

(6) SIMAP similar genes for H1F0 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with H1F0: view

No data available for Paralogs for H1F0 Gene

Variants for H1F0 Gene

Sequence variations from dbSNP and Humsavar for H1F0 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs3884926 -- 37,803,610(+) CATCA(A/C)AACCC upstream-variant-2KB
rs9607493 -- 37,805,294(+) GAGCC(A/C)GAGCC utr-variant-5-prime
rs78748861 -- 37,803,155(+) CTGGG(A/G)CGGGG upstream-variant-2KB
rs739267 -- 37,803,463(+) GCTCC(A/C)CCTCC upstream-variant-2KB
rs79143660 -- 37,804,296(+) AGGAG(C/T)CTTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for H1F0 Gene

Variant ID Type Subtype PubMed ID
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850
dgv4966n71 CNV Loss 21882294
dgv4967n71 CNV Loss 21882294

Variation tolerance for H1F0 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for H1F0 Gene

Disorders for H1F0 Gene

MalaCards: The human disease database

(2) MalaCards diseases for H1F0 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinal cancer
  • malignant neoplasm of retina
sensory system cancer
- elite association - COSMIC cancer census association via MalaCards
Search H1F0 in MalaCards View complete list of genes associated with diseases

Relevant External Links for H1F0

Genetic Association Database (GAD)
H1F0
Human Genome Epidemiology (HuGE) Navigator
H1F0
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
H1F0
genes like me logo Genes that share disorders with H1F0: view

No data available for UniProtKB/Swiss-Prot and Genatlas for H1F0 Gene

Publications for H1F0 Gene

  1. Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene. (PMID: 3084796) Doenecke D. … Tonjes R. (J. Mol. Biol. 1986) 2 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. Every amino acid matters: essential contributions of histone variants to mammalian development and disease. (PMID: 24614311) Maze I. … Allis C.D. (Nat. Rev. Genet. 2014) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for H1F0 Gene

Sources for H1F0 Gene

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