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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

H1F0 Gene

protein-coding GIFtS: 62
GCID: GC22P038201

H1 histone family, member 0

(Previous symbol: H1FV)

Explore 4 diseases affiliated with
H1F0 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
H1 Histone Family, Member 0¹ ²		Histone H1(0)² ³
H1FV¹ ² ³ ⁵		H1.0, H1(0), H1-0²
H10¹ ²		Histone H1.0²
Histone H1'² ³

External Ids:	HGNC: 4714¹	Entrez Gene: 3005²	Ensembl: ENSG00000189060⁷	OMIM: 142708⁵	UniProtKB: P07305³

Export aliases for H1F0 gene to outside databases

Previous GC identifers: GC22P034815 GC22P036444 GC22P036525 GC22P021168

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for H1F0:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in

eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of

each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the

interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.

This gene is intronless and encodes a member of the histone H1 family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H10_HUMAN, P07305

Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0

histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the H1F0 gene promoter:
Pax-5 Pax-6 Lmo2 GATA-2 CREB PPAR-gamma1 deltaCREB STAT3 PPAR-gamma2 Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for H1F0

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H1F0

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1

H1F0 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H1F0 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P038201: view genomic region (about GC identifiers)

Start:	38,201,114 bp from pter	End:	38,203,443 bp from pter
Size:	2,330 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H10_HUMAN, P07305 (See protein sequence)

Recommended Name: Histone H1.0

Size: 194 amino acids; 20863 Da

Subcellular location: Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During

mitosis, it appears in the vicinity of condensed chromosomes

Rna editing: Modified_positions=Not_applicable; Note=Partially edited. In approximately 3.6% of the mRNA molecules, a

new initiator methionine is created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 99

amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the

following peptides specific to that version: 12-21; 22-33; 37-47; 48-67; 68-83; 84-94 and 97-113. The RNA edited

version is called ET-H1.0

Secondary accessions: B2R6I0 B4DRD6 Q6FG88 Q8N6R3

Alternative splicing: 2 isoforms: P07305-1 P07305-2

Explore the universe of human proteins at neXtProt for H1F0: NX_P07305

Post-translational modifications:

Phosphorylated on Ser-17 in RNA edited version¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07305

H1F0 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005309.1

ENSEMBL proteins:

ENSP00000344504

Reactome Protein details: P07305
Human Recombinant Protein Products:

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	Enzo Life Sciences proteins for H1F0
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	Novus Biologicals H1F0 Proteins Novus Biologicals H1F0 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for H1F0

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	IEA	--
GO:0000790	nuclear chromatin	IDA	19882353
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005794	Golgi apparatus	IDA	--

H1F0 for ontologies About GeneDecksing

H1F0 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of H1F0
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	Novus Biologicals H1F0 Antibodies
	Abcam antibodies for H1F0
	Uscn Antibodies for H1F0
	Search ThermoFisher Antibodies for H1F0

Assay Products for H1F0:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for H1F0
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for H1F0

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

H1F0 for domains About GeneDecksing

3 InterPro domains/families:

IPR005819 Histone_H5

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR005818 Histone_H1/H5

Graphical View of Domain Structure for InterPro Entry P07305

ProtoNet protein and cluster: P07305

3 Blocks protein families:

IPB003216 Linker histone

IPB005818 Histone H1/H5

IPB005819 Histone H5 signature

UniProtKB/Swiss-Prot: H10_HUMAN, P07305

Similarity: Belongs to the histone H1/H5 family

Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: H10_HUMAN, P07305

Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0

histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division

Induction: Both the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA edited

version is induced by DTT, vinblastine or TNF (at protein level)

Genatlas biochemistry entry for H1F0:

linker histone 1 family 0,replacement subtype,replication-independent,involved in basal repression of gene expression

miRNA Products:		OriGene 3'-UTR Clone: H1F0 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H1F0
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate H1F0 (see all 22):
		hsa-miR-345 hsa-miR-3607-3p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-606 hsa-miR-340 hsa-miR-550a* hsa-miR-4267

		SwitchGear 3'UTR luciferase reporter plasmid: H1F0 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for H1F0 (see all 7) OriGene shRNA RFP: H1F0 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H1F0

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for H1F0

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H1F0 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H1F0 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: H1F0 (NM_005318)
		Sino Biological Human cDNA Clone for H1F0
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H1F0

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for H1F0
		Search LifeMap BioReagents cell lines for H1F0

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H1F0

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--

H1F0 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for H1F0:

Decreased Salmonella enterica

Increased G2M DNA content

Increased cell death HMECs cel

Increased cell death in breast

Animal Models:
Mouse knock-out H1f0^tm1Ais for H1F0
7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for H1f0):

embryogenesis	growth/size	hematopoietic system	immune system	mortality/aging
normal	reproductive system

H1F0 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of DNA fragmentation factor

	Activation of DNA fragmentation factor	1.00			Granzyme-A Pathway	0.32
	Apoptosis induced DNA fragmentation	1.00

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Cell cycle Chromosome condensation in prometaphase

Cell cycle Chromosome condensation in prometaphase

1.00

Cell cycle_Chromosome condensation in prometaphase

1.00

Apoptotic cleavage of cellular proteins

Apoptotic execution phase

0.73

Activation of cAMP-Dependent PKA

PKA Signaling

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for H1F0

	Histone modification
	Cell cycle Start of DNA replication in early S phase
	Cell cycle Chromosome condensation in prometaphase

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for H1F0

	PKA Signaling
	Granzyme-A Pathway

2 GeneGo (Thomson Reuters) Pathways for H1F0

	Cell cycle Chromosome condensation in prometaphase
	Cell cycle Start of DNA replication in early S phase

4 Reactome Pathways for H1F0

	Activation of DNA fragmentation factor
	Apoptosis induced DNA fragmentation
	Apoptotic execution phase
	Apoptosis

H1F0 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for H1F0

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/108 Interacting proteins for H1F0 (P07305^{2, 3} ENSP00000344504⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 108)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAD51B	O15315²^,³	MINT-19339 MINT-19342 I2D: score=2
NOA1	Q8NC60²^,³	MINT-64923 I2D: score=4
YWHAQ	P27348²^,³, ENSP00000238081⁴	MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000238081
YWHAZ	P63104², ENSP00000309503⁴	MINT-7899812 MINT-7900157 STRING: ENSP00000309503
IPO5	O00410³, ENSP00000261574⁴	I2D: score=2 STRING: ENSP00000261574

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006309	apoptotic DNA fragmentation	TAS	--
GO:0006334	nucleosome assembly	IEA	--
GO:0006915	apoptotic process	TAS	--
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	TAS	--

H1F0 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

H1F0 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for H1F0
1 Novoseek chemical compound relationship for H1F0 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	14.2	2	1743293 (1), 16888724 (1)

Search CenterWatch for drugs/clinical trials and news about H1F0 / H10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for H1F0 gene:

NM_005318.3

Unigene Cluster for H1F0:

H1 histone family, member 0

Hs.226117 [show with all ESTs]

Unigene Representative Sequence: NM_005318

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000340857(uc003aty.3)

miRNA Products:		OriGene 3'-UTR Clone: H1F0 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H1F0
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate H1F0 (see all 22):
		hsa-miR-345 hsa-miR-3607-3p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-606 hsa-miR-340 hsa-miR-550a* hsa-miR-4267

		SwitchGear 3'UTR luciferase reporter plasmid: H1F0 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for H1F0 (see all 7) OriGene shRNA RFP: H1F0 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H1F0

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H1F0 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for H1F0 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: H1F0 (NM_005318)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for H1F0
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat H1F0

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H1F0
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H1F0

Additional cDNA sequence:

AK091372.1 AK299209.1 AK312583.1 BC000145.1 BC029046.1 CR456502.1 CR542220.1

24/33 DOTS entries (see all 33):

DT.100654599 DT.450368 DT.100673364 DT.100890518 DT.100890489 DT.100890486 DT.100038438 DT.100890506

DT.100890511 DT.91999969 DT.100890520 DT.120668817 DT.120668854 DT.100890477 DT.120668865 DT.91999780

DT.100803811 DT.100890481 DT.100890503 DT.120668875 DT.100890522 DT.120668851 DT.91943213 DT.100759741

24/365 AceView cDNA sequences (see all 365):

CR624468 CB270228 CA425534 CR591666 BE875794 CK429953 CR619372 BM552111

AA337113 CR596843 BM679144 CB268631 CR597945 CR620114 CR606842 CR623479

CB529733 CR598888 CR609515 CD620237 CR623269 CR591712 BU689052 CR456502

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for H1F0 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	·	2g	·	2h
SP1:							-		-
SP2:									-		-
SP3:							-

ECgene alternative splicing isoforms for H1F0

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

H1F0 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTGTTTG

About this image

H1F0 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See H1F0 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for H1F0

SOURCE GeneReport for Unigene cluster: Hs.226117

SABiosciences Custom PCR Arrays for H1F0

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for H1F0 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H1F0
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H1F0

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H1F0

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for H1F0 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	H5_CHICK⁶	Histone H5	68(a)	1 ↔ 1	1(53075685-53076257)
African clawed frog (Xenopus laevis)	Amphibia	LOC398662²	hypothetical protein LOC398662	71.7(n)		M22835.1
zebrafish (Danio rerio)	Actinopterygii	wufb23b02²	wufb23b02	74.42(n)		321618 BC056596.1
fruit fly (Drosophila melanogaster)	Insecta	His1:CG33816⁶ His1:CG33861⁶ (see all 23)	His1:CG33861 (see all 23)	26(a) 26(a) (see all 23)	many ↔ many many ↔ many (see all 23)	2L(21456238-21457135) 2L(21531427-21532324)
worm (Caenorhabditis elegans)	Secernentea	hil-1⁶	Histone H1.X	21(a)	possible ortholog	V(14949760-14952775)
thale cress (Arabidopsis thaliana)	eudicotyledons	HIS1-3⁶ AT1G06760⁶ (see all 3)	histone H1.1 (see all 3)	19(a) 18(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2(7845923-7846884) 1(2076504-2077698)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	histone H1, putative, expressed retrotransposon protein, putative, Ty3-gypsy subcl... (see all 4)	19(a) 15(a) (see all 4)	many ↔ many many ↔ many (see all 4)	4(9984198-9985211) 3(33297367-33298860)

ENSEMBL Gene Tree for H1F0 (if available)
TreeFam Gene Tree for H1F0 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for H1F0 gene

HIST1H1T² HIST1H1E² HIST1H1D² HIST1H1B² HIST1H1C² H1FOO² H1FX² HIST1H1A²

6 SIMAP similar genes for H1F0 using alignment to 1 protein entry: H10_HUMAN:

HIST1H1A HIST1H1T HIST1H1B HIST1H1C HIST1H1D HIST1H1E

H1F0 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78748861^1,2		--	38199162(+)	`CTGGGG/ACGGGG`	1	--	us2k¹		1		WA	118
rs6000896^1,2	C,A,	--	38199222(+)	`GGGAGT/GGGGGG`	1	--	us2k¹ tfbs³ trp³		12		NA WA CSA EA	374
rs151085531^1,2		--	38199226(+)	`GGGGGA/GGCTAT`	1	--	us2k¹		0	--	--	--	--
rs140798082^1,2		--	38199345(+)	`AGAAAC/TTGACA`	1	--	us2k¹		0	--	--	--	--
rs6000897^1,2	C,F,A,H,	--	38199364(+)	`AGACGG/AACCTT`	1	--	us2k¹		20		NS EA NA WA CSA	1204
rs139978029^1,2	C,	--	38199418(+)	`CTGTG-/CCCACG`	1	--	us2k¹		0	--	--	--	--
rs193014461^1,2		--	38199456(+)	`ACACCA/GAGTCT`	1	--	us2k¹		0	--	--	--	--
rs739267^1,2	C,F,	--	38199470(+)	`GCTCCC/ACCTCC`	1	--	us2k¹ tfbs³ trp³		3		MN WA NA	422
rs184520590^1,2		--	38199802(+)	`AGAGGA/GGCCCA`	1	--	us2k¹		0	--	--	--	--
rs189044456^1,2		--	38199911(+)	`GAGGTA/CTCTCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for H1F0 (38201114 - 38203443 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for H1F0
1 CNV: 4128

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

H1F0 for disorders           About GeneDecksing

OMIM gene information: 142708    OMIM disorders: --

4 diseases for H1F0:    About MalaCards

ovarian cancer thyroiditis pancreatic cancer pancreatitis

Human Genome Epidemiology (HuGE) Navigator: H1F0 (1 document)

Export disorders for H1F0 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for H1F0 gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with H1F0)

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Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene. (PubMed id 3084796)^{1, 2, 3} Doenecke D. and Tonjes R. (1986)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
The microheterogeneity of the mammalian H1(0) histone. Evidence for an age-dependent deamidation. (PubMed id 9582379)^{1, 2} Lindner H.... Helliger W. (1998)
N- and C-terminal domains determine differential nucle osomal binding geometry and affinity of linker histone isotypes H1(0) and H1c. (PubMed id 22334665)¹ Vyas P. and Brown D.T. (2012)
Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)¹ Zhao J....Yang P. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3005	HGNC: 4714	AceView: H1F0	Ensembl:ENSG00000189060	euGenes: HUgn3005
ECgene: H1F0	H-InvDB: H1F0

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for H1F0	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Histone_H1

Intellectual Property for H1F0 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for H1F0 gene:
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