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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

H1F0 Gene

protein-coding   GIFtS: 62
GCID: GC22P038201

H1 Histone Family, Member 0


(Previous symbol: H1FV)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
H1 Histone Family, Member 01 2     H1-01
H1FV1 2 3 5     H1.01
Histone H1'2 3     H102
Histone H1(0)2 3     H1.0, H1(0), H1-02
H1(0)1     Histone H1.02

External Ids:    HGNC: 47141   Entrez Gene: 30052   Ensembl: ENSG000001890607   OMIM: 1427085   UniProtKB: P073053   

Export aliases for H1F0 gene to outside databases

Previous GC identifers: GC22P034815 GC22P036444 GC22P036525 GC22P021168


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for H1F0 Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a member of the histone H1 family. (provided by RefSeq, Jul 2008)

GeneCards Summary for H1F0 Gene: 
H1F0 (H1 histone family, member 0) is a protein-coding gene. Diseases associated with H1F0 include pancreatic cancer, and pancreatitis, and among its related super-pathways are Granzyme-A Pathway and Apoptotic cleavage of cellular proteins. GO annotations related to this gene include DNA binding. An important paralog of this gene is HIST1H1T.

UniProtKB/Swiss-Prot: H10_HUMAN, P07305
Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The
H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell
division




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the H1F0 gene promoter:
         Pax-5   Pax-6   Lmo2   GATA-2   CREB   PPAR-gamma1   deltaCREB   STAT3   PPAR-gamma2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for H1F0

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H1F0


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

H1F0 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H1F0 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038201:  view genomic region     (about GC identifiers)

Start:
38,201,114 bp from pter      End:
38,203,443 bp from pter
Size:
2,330 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H10_HUMAN, P07305 (See protein sequence)
Recommended Name: Histone H1.0  
Size: 194 amino acids; 20863 Da
Subcellular location: Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles.
During mitosis, it appears in the vicinity of condensed chromosomes
Rna editing: Modified_positions=Not_applicable; Note=Partially edited. In approximately 3.6% of the mRNA
molecules, a new initiator methionine is created by a single uridine insertion in the 5'-UTR, causing an
N-terminal extension of 99 amino acids. The existence of the RNA edited version is supported by direct protein
sequencing by MS/MS of the following peptides specific to that version: 12-21; 22-33; 37-47; 48-67; 68-83; 84-94
and 97-113. The RNA edited version is called ET-H1.0
Secondary accessions: B2R6I0 B4DRD6 Q6FG88 Q8N6R3
Alternative splicing: 2 isoforms:  P07305-1   P07305-2   

Explore the universe of human proteins at neXtProt for H1F0: NX_P07305

Explore proteomics data for H1F0 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on Ser-17 in RNA edited version
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07305

  • H1F0 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    H1F0 Protein Expression
    REFSEQ proteins: NP_005309.1  
    ENSEMBL proteins: 
     ENSP00000344504  
    Reactome Protein details: P07305
    Human Recombinant Protein Products for H1F0: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for H1F0
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    Novus Biologicals H1F0 Proteins
    Novus Biologicals H1F0 Lysates
    Sino Biological Recombinant Protein for H1F0
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for H1F0 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0000790nuclear chromatin IDA19882353
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005794Golgi apparatus IDA--

    H1F0 for ontologies           About GeneDecksing



    H1F0 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for H1F0 
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    LSBio Antibodies in human, mouse, rat for H1F0 

    Assay Products for H1F0: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for H1F0
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for H1F0 
    Cloud-Clone Corp. CLIAs for H1F0


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RIH: Histones / Replication-independent

    3 InterPro protein domains:
     IPR005819 Histone_H5
     IPR011991 WHTH_DNA-bd_dom
     IPR005818 Histone_H1/H5

    Graphical View of Domain Structure for InterPro Entry P07305

    ProtoNet protein and cluster: P07305

    3 Blocks protein domains:
    IPB003216 Linker histone
    IPB005818 Histone H1/H5
    IPB005819 Histone H5 signature


    UniProtKB/Swiss-Prot: H10_HUMAN, P07305
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    H1F0 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H10_HUMAN, P07305
    Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The
    H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell
    division
    Induction: Both the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA
    edited version is induced by DTT, vinblastine or TNF (at protein level)

         Genatlas biochemistry entry for H1F0:
    linker histone 1 family 0,replacement subtype,replication-independent,involved in basal repression of gene
    expression

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI9499053
         
    H1F0 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for H1F0:
     Decreased Salmonella enterica   Increased G2M DNA content  Increased cell death HMECs cel  Increased cell death in breast 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for H1f0):
     embryogenesis  growth/size  hematopoietic system  immune system  mortality/aging 
     normal  reproductive system 

    H1F0 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out H1f0tm1Ais for H1F0

       inGenious Targeting Laboratory - Custom generated mouse model solutions for H1F0 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for H1F0

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for H1F0 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidH1F0 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of H1F0 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H1F0


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for H1F0 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of DNA fragmentation factor
    Activation of DNA fragmentation factor0.32
    Apoptosis induced DNA fragmentation0.32
    Granzyme-A Pathway0.32
    2Apoptotic cleavage of cellular proteins
    Apoptotic execution phase0.73
    3Activation of cAMP-Dependent PKA
    PKA Signaling0.56
    4Activation of the pre-replicative complex
    Cell cycle Start of DNA replication in early S phase0.54
    5Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for H1F0
        Histone modification
    Cell cycle Start of DNA replication in early S phase
    Cell cycle Chromosome condensation in prometaphase

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for H1F0
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for H1F0
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase


    4        Reactome Pathways for H1F0
        Activation of DNA fragmentation factor
    Apoptosis induced DNA fragmentation
    Apoptotic execution phase
    Apoptosis



    H1F0 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for H1F0

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/108 Interacting proteins for H1F0 (P073052, 3 ENSP000003445044) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD51BO153152, 3MINT-19339 MINT-19342 I2D: score=2 
    NOA1Q8NC602, 3MINT-64923 I2D: score=4 
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000238081
    YWHAZP631042, ENSP000003095034MINT-7899812 MINT-7900157 STRING: ENSP00000309503
    IPO5O004103, ENSP000002615744I2D: score=2 STRING: ENSP00000261574
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006309apoptotic DNA fragmentation TAS--
    GO:0006334nucleosome assembly IEA--
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0009451RNA modification IEA--

    H1F0 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    H1F0 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for H1F0 (H10)

    1 Novoseek inferred chemical compound relationship for H1F0 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 14.2 2 1743293 (1), 16888724 (1)

    Search CenterWatch for drugs/clinical trials and news about H1F0 / H10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for H1F0 gene: 
    NM_005318.3  

    Unigene Cluster for H1F0:

    H1 histone family, member 0
    Hs.745024  [show with all ESTs]
    Unigene Representative Sequence: NM_005318
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340857(uc003aty.3)
    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate H1F0 (see all 22):
    hsa-miR-345 hsa-miR-3607-3p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-606 hsa-miR-340 hsa-miR-550a* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidH1F0 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H1F0
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H1F0

    Additional mRNA sequence: 

    AK091372.1 AK299209.1 AK312583.1 BC000145.1 BC029046.1 CR456502.1 CR542220.1 

    24/32 DOTS entries (see all 32):

    DT.100654599  DT.450368  DT.100673364  DT.100890518  DT.100890489  DT.100890486  DT.100890506  DT.100890511 
    DT.91999969  DT.100038438  DT.120668817  DT.120668854  DT.100890520  DT.91999780  DT.100803811  DT.120668865 
    DT.120668875  DT.100890477  DT.100890503  DT.100890522  DT.120668851  DT.91943213  DT.100776592  DT.100829993 

    24/365 AceView cDNA sequences (see all 365):

    BU689052 BE875794 BE793035 CD620235 AL541905 CR601737 CR456502 CD721775 
    CR606708 CB270228 BX460823 CR613392 AL539895 CR615993 CR623479 CB529733 
    CR596843 BE047072 CR606842 CR597945 AA573531 CR620114 CD675060 BM722655 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for H1F0    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h
    SP1:                    -     -                           
    SP2:                          -     -                     
    SP3:                    -                                 


    ECgene alternative splicing isoforms for H1F0

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    H1F0 expression in normal human tissues (normalized intensities)      H1F0 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTGTTTG
    H1F0 Expression
    About this image


    H1F0 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See H1F0 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for H1F0

    SOURCE GeneReport for Unigene cluster: Hs.745024
        SABiosciences Custom PCR Arrays for H1F0
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H1F0
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H1F0

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for H1F0 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H1f01 , 5 H1 histone family, member 01, 5 91.07(n)1
    94.85(a)1
      15 (37.70 cM)5
    149581  NM_008197.31  NP_032223.21 
     790282125 
    chicken
    (Gallus gallus)
    Aves H1F06
    H1F06
    Histone H5
    68(a)
    68(a)
    1 ↔ many
    1 ↔ many
    AADN03018723.1(10155-11037)
    1(50991976-50992548)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986622 hypothetical protein LOC398662 71.7(n)    M22835.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb23b022 wufb23b02 74.42(n)   321618  BC056596.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His1:CG338406
    His1:CG338646
    (see all 23)
    His1:CG33864
    (see all 23)
    26(a)
    26(a)
    (see all 23)
    many ↔ many
    many ↔ many
    (see all 23)
    2L(21496711-21497608)
    2L(21536471-21537368)
    worm
    (Caenorhabditis elegans)
    Secernentea hil-26
    his-246
    (see all 7)
    Histone H1.1
    (see all 7)
    25(a)
    25(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    IV(6294240-6295220)
    X(14490107-14491111)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HHO16
    Histone H1, a linker histone required for nucleoso...
    19(a)
    1 → many
    XVI(308828-309604)


    ENSEMBL Gene Tree for H1F0 (if available)
    TreeFam Gene Tree for H1F0 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for H1F0 gene
    HIST1H1T2  HIST1H1E2  HIST1H1D2  HIST1H1B2  HIST1H1C2  HIST1H1A2  
    6 SIMAP similar genes for H1F0 using alignment to 1 protein entry:     H10_HUMAN:
    HIST1H1A    HIST1H1T    HIST1H1B    HIST1H1C    HIST1H1D    HIST1H1E

    H1F0 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/56 SNPs in H1F0 are shown (see all 56)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs787488611,2
    F--38199162(+) CTGGGG/ACGGGG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs60008961,2
    C,A--38199222(+) GGGAGT/GGGGGG 1 -- us2k1 tfbs3 trp312Minor allele frequency- G:0.15NA WA CSA EA 374
    rs1510855311,2
    C--38199226(+) GGGGGA/GGCTAT 1 -- us2k10--------
    rs1407980821,2
    --38199345(+) AGAAAC/TTGACA 1 -- us2k10--------
    rs60008971,2
    C,F,A,H--38199364(+) AGACGG/AACCTT 1 -- us2k120Minor allele frequency- A:0.13NS EA NA WA CSA 1204
    rs1399780291,2
    C--38199418(+) CTGTG-/CCCACG 1 -- us2k10--------
    rs1930144611,2
    --38199456(+) ACACCA/GAGTCT 1 -- us2k10--------
    rs7392671,2
    C,F--38199470(+) GCTCCC/ACCTCC 1 -- us2k1 tfbs3 trp33Minor allele frequency- A:0.16MN WA NA 422
    rs1845205901,2
    --38199802(+) AGAGGA/GGCCCA 1 -- us2k10--------
    rs1890444561,2
    --38199911(+) GAGGTA/CTCTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for H1F0 (38201114 - 38203443 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for H1F0:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4966n71CNV Loss21882294
    nsv915035CNV Loss21882294
    dgv4967n71CNV Loss21882294
    dgv4965n71CNV Loss21882294
    dgv1406e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142708    OMIM disorders: --

    6 diseases for H1F0:    About MalaCards
    pancreatic cancer    pancreatitis    ovarian cancer    thyroiditis
    endotheliitis    breast cancer


    H1F0 for disorders           About GeneDecksing

    Genetic Association Database (GAD): H1F0
    Human Genome Epidemiology (HuGE) Navigator: H1F0 (1 document)

    Export disorders for H1F0 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for H1F0 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with H1F0)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene. (PubMed id 3084796)1, 2, 3 Doenecke D. and Tonjes R. (1986)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    7. The microheterogeneity of the mammalian H1(0) histone. Evidence for an age-dependent deamidation. (PubMed id 9582379)1, 2 Lindner H.... Helliger W. (1998)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. KIAA1530 protein is recruited by Cockayne syndrome com plementation group protein A (CSA) to participate in transcription-coupled repai r (TCR). (PubMed id 22902626)1 Fei J. and Chen J. (2012)
    10. N- and C-terminal domains determine differential nucle osomal binding geometry and affinity of linker histone isotypes H1(0) and H1c. (PubMed id 22334665)1 Vyas P. and Brown D.T. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3005 HGNC: 4714 AceView: H1F0 Ensembl:ENSG00000189060 euGenes: HUgn3005
    ECgene: H1F0 H-InvDB: H1F0

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for H1F0 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Histone_H1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for H1F0 gene:
    Search GeneIP for patents involving H1F0

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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