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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

H19 Gene

RNA gene   GIFtS: 39
GCID: GC11M002016

H19, imprinted maternally expressed transcript (non-protein...

(Previous names: H19, imprinted maternally expressed untranslated mRNA )
 Explore 79 diseases affiliated with
H19 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for H19    

Aliases
for H19 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 5

Aliases
H19, Imprinted Maternally Expressed Transcript (Non-Protein Coding)1 2     NCRNA000081 2
ASM11 2 5     BWS2 5
D11S813E1 2 5     WT22 5
ASM1 2     H19, Imprinted Maternally Expressed Untranslated MRNA1
LINC000081 2     PRO26052

External Ids:    HGNC: 47131   Entrez Gene: 2831202   Ensembl: ENSG000001306007   OMIM: 1032805   
ORGUL members:    fRNAdb10:FR143442 FR378527 FR217109 FR041821 FR401793 see first 5     
H-InvDB:HIT000338440    
NCBI:AF087017 AF125183 AF087017 M32053 BC106079    
NONCODE:u745 u837 u4124 n333410 n343066 see all 7    
RNAdb:LIT1610 LIT1609    

Export aliases for H19 gene to outside databases

Previous GC identifers: GC11U990149 GC11M001980 GC11M001972 GC11M001976 GC11M001807


Summaries
for H19 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for H19:
This gene expresses a non-coding RNA, and functions as a tumor suppressor. The gene is located in an imprinted region
of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. Expression of this gene and IGF2 are imprinted so
that this gene is only expressed from the maternally-inherited chromosome, and IGF2 is only expressed from the
paternally-inherited chromosome. A region of paternal-specific methylation upstream of this gene is required for the
imprinting of these genes. Mutations in this gene are associated with Beckwith-Wiedemann Syndrome and Wilms
tumorigenesis. (provided by RefSeq, Mar 2009)

Gene Wiki entry for H19

fRNAdb sequence ontologies for H19 - the ORGUL cluster for this gene includes several descriptions:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

View fRNAdb secondary structures for H19

Genomic Views
for H19 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the H19 gene promoter:
         NF-1   NF-1/L   p53   MyoD   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for H19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

H19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H19 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M002016:  view genomic region     (about GC identifiers)

Start:
 2,016,406 bp from pter      End:
 2,022,700 bp from pter
Size:
 6,295 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • FR0401793
  • n333410
  • n336974
  • n346135
  • n343066
  • FR0041821
  • FR0217109
  • FR0143442
  • FR0378527
1833144 1928042 2022940 chr11

Proteins
for H19 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --

Protein Domains /
Families
for H19 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for H19 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:
     Genatlas biochemistry entry for H19:
DNA segment,single copy,probe H19S1,highly expressed in endodermal and mesodermal embryonic tissues,in adult brain,only
in the pons and globus pallidus,paternally imprinted,(?same as ASMG),telomeric imprinting domain at 11p15,containing
ASCL2,IGF2 and H19,silenced and hypermethylated in most Wilms tumor and in bladder carcinomas,but hypomethylated in
benign ovarian teratoma

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H19
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for H19
OriGene shRNA RFP: H19
OriGene siRNA: H19
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H19

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for H19

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for H19
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript Custom all cDNA clones Services for H19
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for H19
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat H19 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for H19
Search LifeMap BioReagents cell lines for H19

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H19

Animal Models:
     Mouse knock-outs for H19: H19tm1Rohl H19tm7Tilg H19tm7Msb H19tm3Msb H19tm5Msb H19tm2Wrk
                                               H19tm1Msb H19tm1.1Sriv H19tm6Msb H19tm1Lda H19tm1.1Kpfe H19tm1Tilg H19tm4Msb
                                               H19tm1.1Msb H19tm2Tilg H19tm1Masu
     15/19 MGI mutant phenotypes (inferred from 29 alleles) (MGI details for H19) (see all 19):
 cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
 endocrine/exocrine gland  growth/size  homeostasis/metabolism  limbs/digits/tail  liver/biliary system 
 mortality/aging  muscle  nervous system  no phenotypic analysis  normal 

H19 for phenotypes           About GeneDecksing


Pathways & Interactions
for H19 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for H19

Drugs & Compounds
for H19 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

H19 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for H19
10/18 Novoseek chemical compound relationships for H19 gene (see all 18)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nap-2 78.3 3 9268640 (1), 9618174 (1), 10049585 (1)
apai 73.6 8 13679437 (1), 9570364 (1), 10473973 (1), 10738131 (1) (see all 7)
rsai 68.4 12 13679437 (1), 10690526 (1), 8564957 (1), 10473973 (1) (see all 8)
cytosine 47.1 3 11889182 (2), 9310237 (1)
5-aza-2'deoxycytidine 45.5 5 16707479 (1), 8842727 (1), 11889182 (1), 11726548 (1)
n-butyl-n-(4-hydroxybutyl)nitrosamine 41.8 2 9886562 (2)
hpaii 37.8 1 17020468 (1)
paraffin 13.8 6 9025899 (1), 9208812 (1), 7855987 (1), 10428315 (1) (see all 6)
ribonucleic acid 7.2 4 9177379 (2), 10843195 (1), 12534338 (1)
acth 5.62 6 7512497 (2), 7531713 (2), 9177379 (2)

Search CenterWatch for drugs/clinical trials and news about H19 

Transcripts
for H19 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
 1 fRNAdb Secondary structure:


Unigene Cluster for H19:

H19, imprinted maternally expressed transcript (non-protein coding)
Hs.533566  [show with all ESTs]
Unigene Representative Sequence: NR_002196
14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000414790(lincRNA)(uc021qby.1 uc001lva.4 uc021qbz.1) ENST00000412788(lincRNA)
ENST00000439725(lincRNA) ENST00000411861(lincRNA) ENST00000417089(lincRNA) ENST00000446406(lincRNA) ENST00000431095(lincRNA)
ENST00000411754(lincRNA) ENST00000422826(lincRNA) ENST00000428066(lincRNA) ENST00000436715(lincRNA) ENST00000447298(lincRNA)
ENST00000442037(lincRNA) ENST00000535745(lincRNA)

miRNA
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Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H19
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate H19
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for H19
OriGene shRNA RFP: H19
OriGene siRNA: H19
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H19
Clone
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript Custom all cDNA clones Services for H19
DNA2.0 Custom Codon Optimized Gene Synthesis Service for H19
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat H19 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for H19
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat H19
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H19
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H19

Additional cDNA sequence: 

AK056774.1 AK092486.1 AK123560.1 AK309887.1 AK311497.1 BC006831.1 BC007513.2 BC009853.1 
BC010185.2 BC013067.1 BC015952.2 BC023213.1 BC040073.1 BC040852.1 BC053636.1 BC053637.1 
BC063564.1 BC063626.1 BC069247.1 BC098439.1 BC106078.1 BC106079.1 BC110657.1 BC115700.1 
NR_002196.1 

24/108 DOTS entries (see all 108):

DT.95378063  DT.91915935  DT.100876775  DT.95378256  DT.100743662  DT.91731337  DT.85104197  DT.100743626 
DT.100743767  DT.85101650  DT.455239  DT.92470792  DT.92391664  DT.120706266  DT.120706354  DT.95378206 
DT.102841233  DT.120706331  DT.100743769  DT.91656375  DT.100743606  DT.100743661  DT.92051978  DT.100743632 

24/2627 AceView cDNA sequences (see all 2627):

N92128 AA479645 CR608274 BE280752 BM698178 AW675662 BF839797 R71588 
AL573822 CR600700 BX406387 BE900540 CR605723 BE280959 H51643 H68737 
BG773568 CR613250 CR594717 H59450 H67884 BX343807 CB990149 CR610115 

GeneLoc Exon Structure


Expression
for H19 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for H19:RNAdb

H19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACCCCCT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

H19 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
9 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
LiverLiver LobuleFetal HepatocytesLiver
LiverLiver LobuleHepatocytesLiver
LiverLiver LobuleMature HepatocytesLiver
HeartMyocardiumCardiac FibroblastsEpicardium
KidneyS-shaped BodyKidney Endothelial CellsEndothelium
PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
TestisSeminiferous TubulesSertoli cellsTestis
AdiposeInterscapular Brown Adipose DepotAdipose
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10/23 LifeMap Cells (see all 23) 
NameCategory
HSF-1 (UC01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
PureStem™ progenitor E69 (Embryonic Progenitor Cell)
PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Genevestigator expression for H19

SOURCE GeneReport for Unigene cluster: Hs.533566
    SABiosciences Custom PCR Arrays for H19
Primer
Products:		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for H19
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat H19
Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H19
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H19
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H19

Orthologs
for H19 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for H19 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia H195 H19 fetal liver mRNA   --   7 (87.97 cM) 142575529 


ENSEMBL Gene Tree for H19 (if available)
TreeFam Gene Tree for H19 (if available) 

Paralogs
for H19 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for H19 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/97 NCBI SNPs in H19 are shown (see all 97)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 11 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs725565501,2
F--1807696(-) RGTRCG/AAGTGT 1 -- nc-transcript-variant5Minor allele frequency- A:0.01MN 408
rs725565511,2
F--1807706(-) CTTGAG/ATCTCR 1 -- nc-transcript-variant5Minor allele frequency- A:0.01MN 408
rs1130469401,2
C--1808139(+) CTGGTC/GCTCAC 1 -- int11Minor allele frequency- G:0.00CSA 1
rs1120568451,2
C--1808140(+) TGGTGC/G/TTCACC 1 -- int11CSA 1
rs125773551,2
H--1808261(+) GTAGCA/CCCATT 1 -- nc-transcript-variant4Minor allele frequency- C:0.00NS EA 394
rs1133906161,2
C--1808347(+) CCTCAC/G/TCTTTC 1 -- spd11CSA 1
rs26688501,2
C--1808498(-) YGSCGG/CGCCAC 1 -- int15Minor allele frequency- C:0.00MN 408
rs27359691,2
C--1808501(-) CCCYGC/GCGSGC 1 -- int15Minor allele frequency- G:0.00MN 364
rs1156962221,2
C,F,--1809225(+) CTCCCC/TGAGCA 1 -- nc-transcript-variant1Minor allele frequency- T:0.03WA 118
rs115427171,2
C--1809265(-) TGCCGG/TAGCCT 1 -- nc-transcript-variant5Minor allele frequency- T:0.00MN 392

HapMap Linkage Disequilibrium report for H19 (2016406 - 2022700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for H19
     2 CNVs: 29891 29893
Human Gene Mutation Database (HGMD): H19

SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H19
DNA2.0 Custom Variant and Variant Library Synthesis for H19

Disorders / Diseases
for H19 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
H19 for disorders           About GeneDecksing

OMIM gene information: 103280 194071 604499 607967 609270 609470    
OMIM disorders: 130650  180860  194071  
20/79 diseases for H19 (see all 79):    About MalaCards
beckwith-wiedemann syndrome    silver-russell syndrome    malignant mixed mullerian tumor    germ cell tumor
pre-eclampsia    hemihypertrophy    testicular germ cell tumor    adrenal adenoma
birth defects    wilms tumor    spontaneous abortion    premature ovarian failure
myeloproliferative disorder    laryngeal squamous cell carcinoma    angiomatosis    wilms tumor 2
wagr syndrome    clear cell sarcoma    cystadenoma    squamous cell carcinoma

10/62 Novoseek disease relationships for H19 gene (see all 62)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
beckwith-wiedemann syndrome 92.4 19 9285792 (2), 8971182 (1), 10857747 (1), 15057946 (1) (see all 18)
embryonal tumor 79.8 2 8618347 (1), 11751681 (1)
wilms tumor 79.7 37 10506193 (3), 7534414 (2), 17325026 (2), 8842727 (2) (see all 24)
cancer embryonal 79 1 9484911 (1)
pediatric germ cell tumor 65.8 1 10189147 (1)
hepatoblastoma 63.1 12 10404060 (4), 10732739 (2), 9570364 (1), 19034281 (1) (see all 8)
hydatidiform mole 59.5 8 7866996 (3), 8188082 (1), 10751088 (1), 10022954 (1) (see all 5)
rhabdomyosarcoma embryonal 57.9 1 12234381 (1)
hemihypertrophy 49.8 2 16532391 (1), 7802016 (1)
bladder carcinoma 49 29 7589512 (5), 11193051 (4), 9886562 (3), 10413100 (3) (see all 9)

GeneTests: H19
Beckwith-Wiedemann Syndrome
Russell-Silver Syndrome

Genetic Association Database (GAD): H19
Human Genome Epidemiology (HuGE) Navigator: H19 (13 documents)

Export disorders for H19 gene to outside databases

Publications
for H19 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for H19 gene, integrated from 9 sources (see all 373):
(articles sorted by number of sources associating them with H19)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The product of the H19 gene may function as an RNA. (PubMed id 1688465)1, 3, 9 Brannan C.I....Tilghman S.M. (1990)
  2. Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. (PubMed id 15885138)1, 4 Petry C.J....Dunger D.B. (2005)
  3. A fine-structure deletion map of human chromosome 11p: analysis of J1 series hybrids. (PubMed id 2595451)1, 3 Glaser T....Jones C. (1989)
  4. The H19 gene imprinting in normal pregnancy and pre-eclampsia. (PubMed id 19342096)1, 9 Yu L....Li L. (2009)
  5. Association of H19 promoter methylation with the expression of H19 and IGF-II genes in adrenocortical tumors. (PubMed id 11889182)1, 9 Gao Z.H....Voutilainen R. (2002)
  6. The H19 non-coding RNA is essential for human tumor growth. (PubMed id 17786216)1, 9 Matouk I.J....Galun E. (2007)
  7. [The aberrant imprinting of insulin-like growth factor II and H19 in human hepatocellular carcinoma] (PubMed id 17294726)1, 9 Wu J....Sun Z.L. (2007)
  8. Expression of the imprinted IGF2 and H19 genes in the endometrium of cases with unexplained infertility. (PubMed id 20042264)1, 9 Korucuoglu U....Menevse S. (2010)
  9. [VIGILIN involves in regulation of imprinting gene IG F2 and H19 in human hepatocellular carcinoma cell] (PubMed id 19950580)1, 9 Ge Y.J....Qin Y. (2009)
  10. Homocysteine harasses the imprinting expression of IG F2 and H19 by demethylation of differentially methylated region between IGF2/H1 9 genes. (PubMed id 19499149)1, 9 Li L....Wang S. (2009)

External Searches for H19 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing H19 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 283120 HGNC: 4713 AceView: H19 Ensembl:ENSG00000130600 euGenes: HUgn283120
ECgene: H19 H-InvDB: H19

Other Databases showing H19 gene

(According to HUGE)
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Specialized Databases showing H19 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for H19 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for H19 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for H19 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for H19 gene:
Search GeneIP for patents involving H19

GeneCards and IP:
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Products
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Advanced Cell Diagnostics
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