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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

H19 Gene

RNA gene   GIFtS: 36
GCID: GC11M002016

H19, Imprinted Maternally Expressed Transcript (Non-Protein...

(Previous names: H19, imprinted maternally expressed untranslated mRNA)
  76 related diseases
at
MalaCards
 

Aliases
for H19 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 10.2

Aliases
H19, Imprinted Maternally Expressed Transcript (Non-Protein Coding)1 2     Long Intergenic Non-Protein Coding RNA 81
ASM12 5     Non-Protein Coding RNA 81
BWS2 5     ASM2
D11S813E2 5     LINC000082
WT22 5     NCRNA000082
H19, Imprinted Maternally Expressed Untranslated MRNA1     PRO26052

External Ids:    HGNC: 47131   Entrez Gene: 2831202   Ensembl: ENSG000001306007   OMIM: 1032805   
ORGUL members:    fRNAdb10:FR217109 FR171508 FR041821 FR143442 FR281471      
H-InvDB12:HIT000338440    
NCBI13:AF087017 M32053 AF087017 AF125183 BC106079    
NONCODE14:u4124 u745 u837 n346135 n333410 n343066 n346077 see top 5      
RNAdb15:LIT1609 EVF34532 EVF31770 LIT1610    

Export aliases for H19 gene to outside databases

Previous GC identifers: GC11U990149 GC11M001980 GC11M001972 GC11M001976 GC11M001807


Summaries
for H19 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for H19 Gene:
This gene expresses a non-coding RNA, and functions as a tumor suppressor. The gene is located in an imprinted
region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. Expression of this gene and IGF2 are
imprinted so that this gene is only expressed from the maternally-inherited chromosome, and IGF2 is only
expressed from the paternally-inherited chromosome. A region of paternal-specific methylation upstream of this
gene is required for the imprinting of these genes. Mutations in this gene are associated with Beckwith-Wiedemann
Syndrome and Wilms tumorigenesis. (provided by RefSeq, Mar 2009)

GeneCards Summary for H19 Gene: 
H19 (H19, imprinted maternally expressed transcript (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with H19 include chromosome 11p15.5-related russell-silver syndrome, and beckwith-wiedemann syndrome due to 11p15 microdeletion.

Gene Wiki entry for H19 Gene

fRNAdb sequence ontologies for H19 - the ORGUL cluster for this gene includes several descriptions:
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for H19

Genomic Views
for H19 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the H19 gene promoter:
         NF-1   NF-1/L   p53   MyoD   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for H19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat H19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

H19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H19 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M002016:  view genomic region     (about GC identifiers)

Start:
 2,016,406 bp from pter      End:
 2,022,700 bp from pter
Size:
 6,295 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for H19

Proteins
for H19 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB: --

Protein Domains /
Families
for H19 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
 HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

  --

Function
for H19 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section
Molecular Function:
     Genatlas biochemistry entry for H19:
DNA segment,single copy,probe H19S1,highly expressed in endodermal and mesodermal embryonic tissues,in adult
brain,only in the pons and globus pallidus,paternally imprinted,(?same as ASMG),telomeric imprinting domain at
11p15,containing ASCL2,IGF2 and H19,silenced and hypermethylated in most Wilms tumor and in bladder
carcinomas,but hypomethylated in benign ovarian teratoma

Phenotypes:
     15/19 MGI mutant phenotypes (inferred from 29 alleles) (MGI details for H19) (see all 19):
 cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
 endocrine/exocrine gland  growth/size  homeostasis/metabolism  limbs/digits/tail  liver/biliary system 
 mortality/aging  muscle  nervous system  no phenotypic analysis  normal 

H19 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for H19: H19tm1Rohl H19tm7Tilg H19tm7Msb H19tm3Msb H19tm5Msb H19tm2Wrk
                                                     H19tm1Msb H19tm1.1Sriv H19tm6Msb H19tm1Lda H19tm1.1Kpfe H19tm1Tilg H19tm4Msb
                                                     H19tm1.1Msb H19tm2Tilg H19tm1Masu

   inGenious Targeting Laboratory - Custom generated mouse model solutions for H19 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for H19

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for H19 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for H19 

miRNA
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate H19
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for H19
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H19

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for H19

Clone
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OriGene clones in human, mouse for H19
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for H19
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for H19
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat H19

Cell Line
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Search LifeMap BioReagents cell lines for H19
In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H19


Pathways & Interactions
for H19 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for H19

Drugs & Compounds
for H19 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

H19 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for H19

10/18 Novoseek inferred chemical compound relationships for H19 gene (see all 18)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nap-2 78.3 3 9268640 (1), 9618174 (1), 10049585 (1)
apai 73.6 8 13679437 (1), 9570364 (1), 10473973 (1), 10738131 (1) (see all 7)
rsai 68.4 12 13679437 (1), 10690526 (1), 8564957 (1), 10473973 (1) (see all 8)
cytosine 47.1 3 11889182 (2), 9310237 (1)
5-aza-2'deoxycytidine 45.5 5 16707479 (1), 8842727 (1), 11889182 (1), 11726548 (1)
n-butyl-n-(4-hydroxybutyl)nitrosamine 41.8 2 9886562 (2)
hpaii 37.8 1 17020468 (1)
paraffin 13.8 6 9025899 (1), 9208812 (1), 7855987 (1), 10428315 (1) (see all 6)
ribonucleic acid 7.2 4 9177379 (2), 10843195 (1), 12534338 (1)
acth 5.62 6 7512497 (2), 7531713 (2), 9177379 (2)

Search CenterWatch for drugs/clinical trials and news about H19

Transcripts
for H19 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
 3 fRNAdb Secondary structures:


Unigene Cluster for H19:

H19, imprinted maternally expressed transcript (non-protein coding)
Hs.533566  [show with all ESTs]
Unigene Representative Sequence: NR_002196
14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000442037 ENST00000411861 ENST00000439725 ENST00000412788 ENST00000414790(uc021qby.1 uc001lva.4 uc021qbz.1)
ENST00000422826 ENST00000446406 ENST00000417089 ENST00000411754 ENST00000431095
ENST00000436715 ENST00000428066 ENST00000447298 ENST00000390168(uc021qca.1)

miRNA
Products:     		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat H19
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate H19
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for H19
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat H19
Clone
Products:     		 OriGene clones in human, mouse for H19
OriGene ORF clones in mouse, rat for H19
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for H19
DNA2.0 Custom Codon Optimized Gene Synthesis Service for H19
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat H19
Primer
Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for H19
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat H19
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat H19
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat H19

Additional mRNA sequence: 

AK056774.1 AK092486.1 AK123560.1 AK309887.1 AK311497.1 BC006831.1 BC007513.2 BC009853.1 
BC010185.2 BC013067.1 BC015952.2 BC023213.1 BC040073.1 BC040852.1 BC053636.1 BC053637.1 
BC063564.1 BC063626.1 BC069247.1 BC098439.1 BC106078.1 BC106079.1 BC110657.1 BC115700.1 
NR_002196.1 

24/104 DOTS entries (see all 104):

DT.95378063  DT.91915935  DT.100876775  DT.100743662  DT.95378256  DT.91731337  DT.85104197  DT.100743626 
DT.85101650  DT.100743767  DT.455239  DT.92391664  DT.92470792  DT.120706266  DT.120706354  DT.95378206 
DT.102841233  DT.100743769  DT.120706331  DT.91656375  DT.100743606  DT.100743632  DT.100743661  DT.100743690 

24/2627 AceView cDNA sequences (see all 2627):

R79144 BC010185 R97708 AW880064 BU751954 CR607245 R96795 BU170025 
F36353 CR598893 H63696 CR594207 CR615643 BF055123 AW673914 R78395 
T50688 F22747 CR625840 CR599037 BG014970 R83855 T50417 H79638 

GeneLoc Exon Structure


Expression
for H19 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for H19:RNAdb

H19 expression in normal human tissues (normalized intensities)      H19 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCACCCCCT
H19 Expression
About this image


H19 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/36 selected tissues (see all 36) fully expand
 
 Cartilage (Muscoskeletal System)    fully expand to see all 11 entries
         HyStem+BMP4-induced 4D20.8 cells
         Human Annulus Fibrosus Cells (HAFC)   
 
 Bone (Muscoskeletal System)    fully expand to see all 11 entries
         HyStem+BMP4-induced 4D20.8 cells
         Human Calvarial Osteoblasts (HCO)   
 
 Uncategorized (Uncategorized)    fully expand to see all 6 entries
         PureStem Progenitor EN7
 
 Heart (Cardiovascular System)    fully expand to see all 5 entries
         Cardiac Fibroblasts Myocardium
         Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
         Coronary Artery Smooth Muscle Cells (CASMC)   
 
 Brain (Nervous System)    fully expand to see all 5 entries
         Postnatal Endothelial Cells Blood Brain Barrier
         Human Brain Vascular Pericyte (HBVP)   

Genevestigator expression for H19

SOURCE GeneReport for Unigene cluster: Hs.533566
    SABiosciences Custom PCR Arrays for H19
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SABiosciences RT2 qPCR Primer Assay in human, mouse / rat H19
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H19

Orthologs
for H19 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for H19 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia H195 H19 fetal liver mRNA   --   7 (87.97 cM) 142575529 


ENSEMBL Gene Tree for H19 (if available)
TreeFam Gene Tree for H19 (if available)

Paralogs
for H19 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for H19 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/144 SNPs in H19 are shown (see all 144)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 11 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1453309411,2
--1949981(+) CCTCCA/GCAAGC 1 -- ds50010--------
rs115647411,2
C,F--1950185(-) GGGGGG/ACATGG 1 -- ds50011Minor allele frequency- A:0.12EA 120
rs1163091181,2
F--1950255(+) GTCCTC/GGAGAC 1 -- ds50011Minor allele frequency- G:0.03WA 118
rs37412191,2
C,F,A,H--1950477(-) GCCTGT/CGCAGG 1 -- nc-transcript-variantese327Minor allele frequency- C:0.32EA NA MN NS EU 4523
rs725565501,2
F--1950515(-) RGTRCG/AAGTGT 1 -- nc-transcript-variant5Minor allele frequency- A:0.01MN 408
rs28397041,2
C,F,A--1950517(-) TCAGTA/G/TCGAGT 2 -- nc-transcript-variantese317EA NA MN CSA WA EU 1272
rs28397031,2
C,F,A--1950520(-) GTCTCA/G/TGTACG 2 -- nc-transcript-variantese317EU NA MN CSA WA EA 1605
rs725565511,2
C,F--1950525(-) CTTGAG/ATCTCR 1 -- nc-transcript-variant5Minor allele frequency- A:0.01MN 408
rs37412161,2
C,F,A,H--1950575(-) AATTTA/TATTTG 1 -- nc-transcript-variant15Minor allele frequency- T:0.09EA NA MN NS EU 2975
rs115427241,2
C--1950631(+) AGAAAA/TAAGGA 1 -- nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for H19 (2016406 - 2022700 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/14 variations for H19 (see all 14):    About this table     
Variant IDTypeSubtypePubMed ID
esv29980CNV Loss17803354
dgv991n71CNV Loss21882294
dgv989n71CNV Loss21882294
dgv988n71CNV Loss21882294
nsv522320CNV Loss19592680
nsv896767CNV Loss21882294
nsv896731CNV Loss21882294
dgv983n71CNV Loss21882294
dgv987n71CNV Loss21882294
nsv469926CNV Loss18288195


Human Gene Mutation Database (HGMD): H19
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing H19
DNA2.0 Custom Variant and Variant Library Synthesis for H19

Disorders / Diseases
for H19 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
 OMIM gene information: 103280OMIM information: 609124 194071 604499 607967 609270 609470    
OMIM disorders: 130650  180860  194071  
20/76 diseases for H19 (see all 76):    About MalaCards
chromosome 11p15.5-related russell-silver syndrome    beckwith-wiedemann syndrome due to 11p15 microdeletion    beckwith-wiedemann syndrome due to imprinting defect of 11p15    hemihypertrophy
beckwith-wiedemann syndrome    silver-russell syndrome    malignant mixed mullerian tumor    wilms tumor 2
angiomatosis    hepatoblastoma    bladder carcinoma    juvenile nasopharyngeal angiofibroma
wagr syndrome    gigantism    germ cell tumors    clear cell sarcoma
albright's hereditary osteodystrophy    adrenal adenoma    growth disorders    aniridia


H19 for disorders           About GeneDecksing

10/62 Novoseek inferred disease relationships for H19 gene (see all 62)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
beckwith-wiedemann syndrome 92.4 19 9285792 (2), 8971182 (1), 10857747 (1), 15057946 (1) (see all 18)
embryonal tumor 79.8 2 8618347 (1), 11751681 (1)
wilms tumor 79.7 37 10506193 (3), 7534414 (2), 17325026 (2), 8842727 (2) (see all 24)
cancer embryonal 79 1 9484911 (1)
pediatric germ cell tumor 65.8 1 10189147 (1)
hepatoblastoma 63.1 12 10404060 (4), 10732739 (2), 9570364 (1), 19034281 (1) (see all 8)
hydatidiform mole 59.5 8 7866996 (3), 8188082 (1), 10751088 (1), 10022954 (1) (see all 5)
rhabdomyosarcoma embryonal 57.9 1 12234381 (1)
hemihypertrophy 49.8 2 16532391 (1), 7802016 (1)
bladder carcinoma 49 29 7589512 (5), 11193051 (4), 9886562 (3), 10413100 (3) (see all 9)

GeneTests: H19
GeneReviews: H19
Genetic Association Database (GAD): H19
Human Genome Epidemiology (HuGE) Navigator: H19 (13 documents)

Export disorders for H19 gene to outside databases

Publications
for H19 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for H19 gene, integrated from 9 sources (see all 384):
(articles sorted by number of sources associating them with H19)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The H19 gene imprinting in normal pregnancy and pre-eclampsia. (PubMed id 19342096)1, 4, 9 Yu L....Li L. (2009)
  2. Genetic Predisposition to Idiopathic Recurrent Spontaneous Abortion: Contribution of Genetic Variations in IGF-2 and H19 Imprinted Genes. (PubMed id 18573128)1, 4, 9 Ostojic S....Peterlin B. (2008)
  3. Polymorphisms in the H19 Gene and the Risk of Bladder Cancer. (PubMed id 18262338)1, 4, 9 Verhaegh G.W....Kiemeney L.A. (2008)
  4. Association of breast cancer susceptibility variants with risk of pancreatic cancer. (PubMed id 19843670)1, 4, 9 Couch F.J....Petersen G.M. (2009)
  5. The product of the H19 gene may function as an RNA. (PubMed id 1688465)1, 3, 9 Brannan C.I....Tilghman S.M. (1990)
  6. Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes. (PubMed id 20639793)1, 4 Adkins R.M....Krushkal J. (2010)
  7. FGFR2 and other loci identified in genome-wide associ ation studies are associated with breast cancer in African-American and younger women. (PubMed id 20554749)1, 4 Barnholtz-Sloan J.S....Millikan R.C. (2010)
  8. Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PubMed id 20145138)1, 4 Odefrey F....Southey M.C. (2010)
  9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
  10. Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. (PubMed id 15885138)1, 4 Petry C.J....Dunger D.B. (2005)

External Searches for H19 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing H19 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 283120 HGNC: 4713 AceView: H19 Ensembl:ENSG00000130600 euGenes: HUgn283120
ECgene: H19 H-InvDB: H19

Other Databases showing H19 gene

(According to HUGE)
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Specialized Databases showing H19 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for H19 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for H19 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for H19 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for H19 gene:
Search GeneIP for patents involving H19

GeneCards and IP:
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Products
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