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H19 Gene

RNA gene GIFtS: 35
GCID: GC11M002016

H19, Imprinted Maternally Expressed Transcript (Non-Protein...

(Previous names: H19, imprinted maternally expressed untranslated mRNA)

See H19-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Subcategory (RNA class): processed_transcript

Quality score for this RNA gene is 3

Aliases
H19, Imprinted Maternally Expressed Transcript (Non-Protein Coding)¹ ²		Long Intergenic Non-Protein Coding RNA 8¹
ASM1² ⁵		Non-Protein Coding RNA 8¹
BWS² ⁵		ASM²
D11S813E² ⁵		LINC00008²
WT2² ⁵		NCRNA00008²
H19, Imprinted Maternally Expressed Untranslated MRNA¹		PRO2605²

External Ids:	HGNC: 4713¹	Entrez Gene: 283120²	Ensembl: ENSG00000130600⁷	OMIM: 103280⁵

Export aliases for H19 gene to outside databases

Previous GC identifers: GC11U990149 GC11M001980 GC11M001972 GC11M001976 GC11M001807

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for H19 Gene:

This gene expresses a non-coding RNA, and functions as a tumor suppressor. The gene is located in an imprinted

region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. Expression of this gene and IGF2 are

imprinted so that this gene is only expressed from the maternally-inherited chromosome, and IGF2 is only

expressed from the paternally-inherited chromosome. A region of paternal-specific methylation upstream of this

gene is required for the imprinting of these genes. Mutations in this gene are associated with Beckwith-Wiedemann

Syndrome and Wilms tumorigenesis. (provided by RefSeq, Mar 2009)

GeneCards Summary for H19 Gene:

H19 (H19, imprinted maternally expressed transcript (non-protein coding)) is an RNA gene, and is affiliated with the processed_transcript RNA class. Diseases associated with H19 include hemihypertrophy, and beckwith-wiedemann syndrome.

Gene Wiki entry for H19 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000011.9 NC_018922.2 NT_009237.19

Regulatory elements:

Regulatory transcription factor binding sites in the H19 gene promoter:
NF-1 NF-1/L p53 MyoD
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for H19

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat H19

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

H19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
H19 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M002016: view genomic region (about GC identifiers)

Start:	2,016,406 bp from pter	End:	2,022,700 bp from pter
Size:	6,295 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for H19

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB: --

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

LNCRNA: Long non-coding RNAs

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for H19:

DNA segment,single copy,probe H19S1,highly expressed in endodermal and mesodermal embryonic tissues,in adult

brain,only in the pons and globus pallidus,paternally imprinted,(?same as ASMG),telomeric imprinting domain at

11p15,containing ASCL2,IGF2 and H19,silenced and hypermethylated in most Wilms tumor and in bladder

carcinomas,but hypomethylated in benign ovarian teratoma

Phenotypes:
10 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for H19):

cellular	digestive/alimentary	embryogenesis	growth/size/body	mortality/aging
nervous system	no phenotypic analysis	normal	skeleton	tumorigenesis

Find genes that share phenotypes with H19           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for H19: H19^tm7Tilg H19^tm4Msb H19^tm7Msb H19^tm1Masu H19^tm1Tilg H19^tm1.1Sriv
                                                     H19^tm1Lda

genOway: Develop your customized and physiologically relevant rodent model for H19

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H19

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-13208 VA4-10913 VB1-14257) for H19

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for H19
Interactions:

GeneGlobe Interaction Network for H19

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for H19

Selected Novoseek inferred chemical compound relationships for H19 gene (see all 18) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nap-2	78.3	3	9268640 (1), 9618174 (1), 10049585 (1)
apai	73.6	8	13679437 (1), 9570364 (1), 10473973 (1), 10738131 (1) (see all 7)
rsai	68.4	12	13679437 (1), 10690526 (1), 8564957 (1), 10473973 (1) (see all 8)
cytosine	47.1	3	11889182 (2), 9310237 (1)
5-aza-2'deoxycytidine	45.5	5	16707479 (1), 8842727 (1), 11889182 (1), 11726548 (1)
n-butyl-n-(4-hydroxybutyl)nitrosamine	41.8	2	9886562 (2)
hpaii	37.8	1	17020468 (1)
paraffin	13.8	6	9025899 (1), 9208812 (1), 7855987 (1), 10428315 (1) (see all 6)
ribonucleic acid	7.2	4	9177379 (2), 10843195 (1), 12534338 (1)
acth	5.62	6	7512497 (2), 7531713 (2), 9177379 (2)

Find genes that share compounds with H19 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Unigene Cluster for H19:

H19, imprinted maternally expressed transcript (non-protein coding)

Hs.533566 [show with all ESTs]

Unigene Representative Sequence: NR_002196

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000442037(processed_transcript) ENST00000411861(processed_transcript) ENST00000439725(processed_transcript) ENST00000412788(processed_transcript) ENST00000414790(processed_transcript)

ENST00000422826(processed_transcript) ENST00000446406(processed_transcript) ENST00000417089(processed_transcript) ENST00000411754(processed_transcript) ENST00000431095(processed_transcript)

ENST00000436715(processed_transcript) ENST00000428066(processed_transcript) ENST00000447298(processed_transcript) ENST00000390168(processed_transcript)

miRNA Products:		Block miRNA regulation of human, mouse, rat H19 using miScript Target Protectors
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		Predesigned siRNA for gene silencing in human, mouse, rat H19

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		GenScript Custom all cDNA clones Services for H19
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for H19
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat H19

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		Pre-validated RT² qPCR Primer Assay in human, mouse / rat H19
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		QuantiFast Probe-based Assays in human, mouse, rat H19

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-13208 VA4-10913 VB1-14257) for H19

Additional mRNA sequence:

AK056774.1 AK092486.1 AK123560.1 AK309887.1 AK311497.1 BC006831.1 BC007513.2 BC009853.1

BC010185.2 BC013067.1 BC015952.2 BC023213.1 BC040073.1 BC040852.1 BC053636.1 BC053637.1

BC063564.1 BC063626.1 BC069247.1 BC098439.1 BC106078.1 BC106079.1 BC110657.1 BC115700.1

NR_002196.1

Selected DOTS entries (see all 104):

DT.95378063 DT.91915935 DT.100876775 DT.100743662 DT.95378256 DT.91731337 DT.85104197 DT.100743626

DT.85101650 DT.100743767 DT.455239 DT.92391664 DT.92470792 DT.120706266 DT.120706354 DT.95378206

DT.102841233 DT.100743769 DT.120706331 DT.91656375 DT.100743606 DT.100743632 DT.100743661 DT.100743690

Selected AceView cDNA sequences (see all 2627):

R97708 AA341793 AA369043 F36353 CR598893 H63696 CR594207 CA448792

BM838030 AI219634 H67013 CR618478 CR610115 N53685 AW675192 BE900558

CB989602 CR602619 BC010185 AL546714 CR608274 AA478276 BI087416 F24651

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for H19:none

H19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCCACCCCCT

About this image

H19 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 25) fully expand


Cartilage (Muscoskeletal System) fully expand to see all 10 entries
HyStem+BMP4-induced 4D20.8 cells

Bone (Muscoskeletal System) fully expand to see all 10 entries
HyStem+BMP4-induced 4D20.8 cells

Liver (Hepatobiliary System) fully expand to see all 4 entries
Fetal Hepatocytes Liver Lobule

Adipose (Muscoskeletal System) fully expand to see all 4 entries
Interscapular Brown Adipose Depot
HyStem+BMP4-induced E15 cells

Pancreas (Endocrine System) fully expand to see all 4 entries
Endocrine Progenitor Cells Ventral Pancreatic Bud

H19 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

--

SOURCE GeneReport for Unigene cluster: Hs.533566

Custom PCR Arrays for H19

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		Pre-validated RT² qPCR Primer Assay in human, mouse / rat H19
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H19

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for H19 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	H19⁵	H19 fetal liver mRNA	--		7 (87.97 cM) 142575529

ENSEMBL Gene Tree for H19 (if available)
TreeFam Gene Tree for H19 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145330941^1,2		--	1949981(+)	`CCTCCA/GCAAGC`	1	--	ds500¹		0	--	--	--	--
rs11564741^1,2	C,F	--	1950185(-)	`GGGGGG/ACATGG`	1	--	ds500¹		1		EA	120
rs116309118^1,2	F	--	1950255(+)	`GTCCTC/GGAGAC`	1	--	ds500¹		1		WA	118
rs3741219^1,2	C,F,A,H	--	1950477(-)	`GCCTGT/CGCAGG`	1	--	nc-transcript-variantese³		27		EA NA MN NS EU	4523
rs72556550^1,2	F	--	1950515(-)	`RGTRCG/AAGTGT`	1	--	nc-transcript-variant		5		MN	408
rs2839704^1,2	C,F,A	--	1950517(-)	`TCAGTA/G/TCGAGT`	2	--	nc-transcript-variantese³		17		EA NA MN CSA WA EU	1272
rs2839703^1,2	C,F,A	--	1950520(-)	`GTCTCA/G/TGTACG`	2	--	nc-transcript-variantese³		17		EU NA MN CSA WA EA	1605
rs72556551^1,2	C,F	--	1950525(-)	`CTTGAG/ATCTCR`	1	--	nc-transcript-variant		5		MN	408
rs3741216^1,2	C,F,A,H	--	1950575(-)	`AATTTA/TATTTG`	1	--	nc-transcript-variant		15		EA NA MN NS EU	2975
rs11542724^1,2	C	--	1950631(+)	`AGAAAA/TAAGGA`	1	--	nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for H19 (2016406 - 2022700 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for H19 (see all 14): About this table

Variant ID	Type	Subtype	PubMed ID
esv29980	CNV	Loss	17803354
dgv991n71	CNV	Loss	21882294
dgv989n71	CNV	Loss	21882294
dgv988n71	CNV	Loss	21882294
nsv522320	CNV	Loss	19592680
nsv896767	CNV	Loss	21882294
nsv896731	CNV	Loss	21882294
dgv983n71	CNV	Loss	21882294
dgv987n71	CNV	Loss	21882294
nsv469926	CNV	Loss	18288195

Human Gene Mutation Database (HGMD): H19

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing H19

DNA2.0 Custom Variant and Variant Library Synthesis for H19

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 103280
OMIM disorders: 130650  180860  194071
15 diseases for H19:
About MalaCards

hemihypertrophy beckwith-wiedemann syndrome silver-russell syndrome due to 11p15 microduplication beckwith-wiedemann syndrome due to imprinting defect of 11p15

silver-russell syndrome due to imprinting defect of 11p15 beckwith-wiedemann syndrome due to 11p15 microdeletion silver-russell syndrome wilms tumor

hepatoblastoma bladder carcinoma juvenile nasopharyngeal angiofibroma wilms tumor 2

angiomatosis wagr syndrome albright's hereditary osteodystrophy

Find genes that share disorders with H19 About GenesLikeMe

Selected Novoseek inferred disease relationships for H19 gene (see all 62) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
beckwith-wiedemann syndrome	92.4	19	9285792 (2), 8971182 (1), 10857747 (1), 15057946 (1) (see all 18)
embryonal tumor	79.8	2	8618347 (1), 11751681 (1)
wilms tumor	79.7	37	10506193 (3), 7534414 (2), 17325026 (2), 8842727 (2) (see all 24)
cancer embryonal	79	1	9484911 (1)
pediatric germ cell tumor	65.8	1	10189147 (1)
hepatoblastoma	63.1	12	10404060 (4), 10732739 (2), 9570364 (1), 19034281 (1) (see all 8)
hydatidiform mole	59.5	8	7866996 (3), 8188082 (1), 10751088 (1), 10022954 (1) (see all 5)
rhabdomyosarcoma embryonal	57.9	1	12234381 (1)
hemihypertrophy	49.8	2	16532391 (1), 7802016 (1)
bladder carcinoma	49	29	7589512 (5), 11193051 (4), 9886562 (3), 10413100 (3) (see all 9)

GeneTests: H19
GeneReviews: H19
Genetic Association Database (GAD): H19
Human Genome Epidemiology (HuGE) Navigator: H19 (13 documents)

Export disorders for H19 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for H19 gene, integrated from 10 sources (see all 382):
(articles sorted by number of sources associating them with H19)

Utopia: connect your pdf to the dynamic
world of online information

The H19 gene imprinting in normal pregnancy and pre-eclampsia. (PubMed id 19342096)^{1, 4, 9} Yu L....Li L. (Placenta 2009)
Genetic predisposition to idiopathic recurrent spontaneous abortion: contribution of genetic variations in IGF-2 and H19 imprinted genes. (PubMed id 18573128)^{1, 4, 9} OstojiA8 S....Peterlin B. (Am. J. Reprod. Immunol. 2008)
Polymorphisms in the H19 gene and the risk of bladder cancer. (PubMed id 18262338)^{1, 4, 9} Verhaegh G.W....Kiemeney L.A. (Eur. Urol. 2008)
Association of breast cancer susceptibility variants with risk of pancreatic cancer. (PubMed id 19843670)^{1, 4, 9} Couch F.J....Petersen G.M. (amp 2009)
The product of the H19 gene may function as an RNA. (PubMed id 1688465)^{1, 3, 9} Brannan C.I....Tilghman S.M. (Mol. Cell. Biol. 1990)
Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes. (PubMed id 20639793)^{1, 4} Adkins R.M....Krushkal J. (Pediatr. Res. 2010)
FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women. (PubMed id 20554749)^{1, 4} Barnholtz-Sloan J.S....Millikan R.C. (Carcinogenesis 2010)
Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PubMed id 20145138)^{1, 4} Odefrey F....Southey M.C. (Cancer Res. 2010)
Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)^{1, 4} Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. (PubMed id 15885138)^{1, 4} Petry C.J....Dunger D.B. (BMC Genet. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 283120	HGNC: 4713	AceView: H19	Ensembl:ENSG00000130600	euGenes: HUgn283120
ECgene: H19	H-InvDB: H19

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for H19	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for H19	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for H19 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for H19 gene:
Search GeneIP for patents involving H19

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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	EMD Millipore genomic analysis products

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	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for H19
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for H19
	OriGene qSTAR qPCR primer pairs in human, mouse for H19		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for H19		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for H19		OriGene Custom Protein Services for H19

	Block miRNA regulation of human, mouse, rat H19 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing H19
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat H19		Predesigned siRNA for gene silencing in human, mouse, rat H19
	QuantiFast Probe-based Assays in human, mouse, rat H19		Search QuantiTect SYBR Green Assays in human, mouse, rat H19
	Custom PCR Arrays for H19		Search Chromatin IP Primers for H19
	Pre-validated RT² qPCR Primer Assay in human, mouse / rat H19		GeneGlobe Interaction Network for H19
	Regulatory tfbs in H19 promoter

	GenScript Custom Purified and Recombinant Proteins Services for H19		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for H19
	GenScript Custom Assay Services for H19		GenScript Custom overexpressing Cell Line Services for H19
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

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Search Tocris compounds for H19

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	Protein Production Services
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
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	Search for Antibodies for H19 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for H19
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Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
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Browse ESI BIO Cell Lines and PureStem Progenitors for H19

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for H19

	Browse SwitchGear 3'UTR luciferase reporter plasmids for H19
	Browse SwitchGear Promoter luciferase reporter plasmids for H19

Search ThermoFisher Antibodies for H19

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat H19

Browse compounds at ApexBio

Search Addgene for plasmids for H19

	Search eBioscience for proteins for H19
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	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for H19

	Search antibodies-online for antibodies for H19
	Search antibodies-online for kits for H19
	Search antibodies-online for peptides for H19
	Search antibodies-online for proteins for H19

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes H19 gene at Home site.

Version: 3.12.314 1 Feb 2015
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H19 Gene

H19, Imprinted Maternally Expressed Transcript (Non-Protein...

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Beckwith-Wiedemann Syndrome
Gastric Cancer
Adenoma Adrenocortical
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bladder cancer
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congenital malformation
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H19 Gene

H19, Imprinted Maternally Expressed Transcript (Non-Protein...

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