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Aliases for H19 Gene

Subcategory (RNA class) for H19 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for H19 Gene

  • H19, Imprinted Maternally Expressed Transcript (Non-Protein Coding) 2 3
  • H19, Imprinted Maternally Expressed Untranslated MRNA 2 3
  • Long Intergenic Non-Protein Coding RNA 8 2 3
  • Non-Protein Coding RNA 8 2
  • NCRNA00008 3
  • LINC00008 3
  • D11S813E 3
  • ASM1 3
  • BWS 3
  • ASM 3
  • WT2 3

External Ids for H19 Gene

Previous GeneCards Identifiers for H19 Gene

  • GC11U990149
  • GC11M001980
  • GC11M001972
  • GC11M001976
  • GC11M002016
  • GC11M001807

Summaries for H19 Gene

Entrez Gene Summary for H19 Gene

  • This gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. This gene is only expressed from the maternally-inherited chromosome, whereas IGF2 is only expressed from the paternally-inherited chromosome. The product of this gene is a long non-coding RNA which functions as a tumor suppressor. Mutations in this gene have been associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for H19 Gene

H19 (H19, Imprinted Maternally Expressed Transcript (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with H19 include hemihypertrophy and beckwith-wiedemann syndrome due to 11p15 microdeletion.

Gene Wiki entry for H19 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H19 Gene

Genomics for H19 Gene

Regulatory Elements for H19 Gene

Genomic Location for H19 Gene

Chromosome:
11
Start:
1,995,163 bp from pter
End:
2,001,470 bp from pter
Size:
6,308 bases
Orientation:
Minus strand

Genomic View for H19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for H19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H19 Gene

Proteins for H19 Gene

Post-translational modifications for H19 Gene

No Post-translational modifications

No data available for DME Specific Peptides for H19 Gene

Domains & Families for H19 Gene

Gene Families for H19 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with H19: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for H19 Gene

Function for H19 Gene

Molecular function for H19 Gene

GENATLAS Biochemistry:
DNA segment,single copy,probe H19S1,highly expressed in endodermal and mesodermal embryonic tissues,in adult brain,only in the pons and globus pallidus,paternally imprinted,(?same as ASMG),telomeric imprinting domain at 11p15,containing ASCL2,IGF2 and H19,silenced and hypermethylated in most Wilms tumor and in bladder carcinomas,but hypomethylated in benign ovarian teratoma
genes like me logo Genes that share phenotypes with H19: view

Animal Models for H19 Gene

MGI Knock Outs for H19:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H19

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for H19 Gene

Localization for H19 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for H19 Gene

Pathways & Interactions for H19 Gene

SuperPathways for H19 Gene

No Data Available

Interacting Proteins for H19 Gene

Gene Ontology (GO) - Biological Process for H19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for H19 Gene

Drugs & Compounds for H19 Gene

(5) Drugs for H19 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 145
Zinc Approved Pharma 1404
thymidine Experimental Pharma 0
ACTH Pharma 0
tyrosine Nutra 547

(13) Additional Compounds for H19 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Aza-2deoxycytidine
Agar
Agarose
APAI
Cytosine
  • 4-Amino-2(1H)-pyrimidinone
  • 4-Amino-2-hydroxypyrimidine
  • 4-Amino-2-oxo-1,2-dihydropyrimidine
  • 4-Aminouracil
  • Cytosine
71-30-7
genes like me logo Genes that share compounds with H19: view

Transcripts for H19 Gene

Unigene Clusters for H19 Gene

H19, imprinted maternally expressed transcript (non-protein coding):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for H19

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for H19 Gene

No ASD Table

Relevant External Links for H19 Gene

GeneLoc Exon Structure for
H19
ECgene alternative splicing isoforms for
H19

Expression for H19 Gene

mRNA expression in normal human tissues for H19 Gene

mRNA differential expression in normal tissues according to GTEx for H19 Gene

This gene is overexpressed in Muscle - Skeletal (x11.1) and Adrenal Gland (x4.6).

SOURCE GeneReport for Unigene cluster for H19 Gene Hs.533566

genes like me logo Genes that share expression patterns with H19: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for H19 Gene

Orthologs for H19 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for H19 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia H19 16
Species with no ortholog for H19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for H19 Gene

ENSEMBL:
Gene Tree for H19 (if available)
TreeFam:
Gene Tree for H19 (if available)

Paralogs for H19 Gene

No data available for Paralogs for H19 Gene

Variants for H19 Gene

Structural Variations from Database of Genomic Variants (DGV) for H19 Gene

Variant ID Type Subtype PubMed ID
nsv896727 CNV Gain 21882294
nsv896731 CNV Loss 21882294
nsv467645 CNV Gain 19166990
nsv469926 CNV Loss 18288195
dgv983n71 CNV Loss 21882294
esv29980 CNV Loss 17803354
nsv522320 CNV Loss 19592680
dgv987n71 CNV Loss 21882294
dgv988n71 CNV Loss 21882294
dgv989n71 CNV Loss 21882294
dgv991n71 CNV Loss 21882294
nsv896767 CNV Loss 21882294
nsv896768 CNV Gain 21882294
nsv896769 CNV Gain 21882294

Relevant External Links for H19 Gene

HapMap Linkage Disequilibrium report
H19
Human Gene Mutation Database (HGMD)
H19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for H19 Gene

Disorders for H19 Gene

MalaCards: The human disease database

(21) MalaCards diseases for H19 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Relevant External Links for H19

Genetic Association Database (GAD)
H19
Human Genome Epidemiology (HuGE) Navigator
H19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
H19
genes like me logo Genes that share disorders with H19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for H19 Gene

Publications for H19 Gene

  1. H19 RNA downregulation stimulated melanogenesis in melasma. (PMID: 19968822) Kim N.H. … Lee A.Y. (Pigment Cell Melanoma Res 2010) 23 67
  2. The oncofetal H19 RNA connection: hypoxia, p53 and cancer. (PMID: 20117150) Matouk I.J. … Hochberg A. (Biochim. Biophys. Acta 2010) 23 67
  3. Homocysteine harasses the imprinting expression of IGF2 and H19 by demethylation of differentially methylated region between IGF2/H19 genes. (PMID: 19499149) Li L. … Wang S. (Acta Biochim. Biophys. Sin. (Shanghai) 2009) 23 67
  4. [H19 expression in placenta with pre-eclampsia]. (PMID: 19570415) Zhao D. … Zhou Y.G. (Zhonghua Fu Chan Ke Za Zhi 2009) 23 67
  5. The H19 gene imprinting in normal pregnancy and pre-eclampsia. (PMID: 19342096) Yu L. … Li L. (Placenta 2009) 23 67

Products for H19 Gene

Sources for H19 Gene

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