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Aliases for H19 Gene

Subcategory (RNA class) for H19 Gene

processed_transcript

Quality Score for this RNA gene is

3

Aliases for H19 Gene

  • H19, Imprinted Maternally Expressed Transcript (Non-Protein Coding) 2 3
  • H19, Imprinted Maternally Expressed Untranslated MRNA 2 3
  • Long Intergenic Non-Protein Coding RNA 8 2 3
  • D11S813E 3 6
  • ASM1 3 6
  • BWS 3 6
  • WT2 3 6
  • Non-Protein Coding RNA 8 2
  • NCRNA00008 3
  • LINC00008 3
  • ASM 3

External Ids for H19 Gene

Summaries for H19 Gene

Entrez Gene Summary for H19 Gene

  • This gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. This gene is only expressed from the maternally-inherited chromosome, whereas IGF2 is only expressed from the paternally-inherited chromosome. The product of this gene is a long non-coding RNA which functions as a tumor suppressor. Mutations in this gene have been associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for H19 Gene

H19 (H19, Imprinted Maternally Expressed Transcript (Non-Protein Coding)) is a RNA Gene, and belongs to processed_transcript RNA class. Diseases associated with H19 include beckwith-wiedemann syndrome and silver-russell syndrome due to 11p15 microduplication.

Gene Wiki entry for H19 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for H19 Gene

Genomics for H19 Gene

Genomic Location for H19 Gene

Start:
1,995,163 bp from pter
End:
2,001,470 bp from pter
Size:
6,308 bases
Orientation:
Minus strand

Genomic View for H19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for H19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H19 Gene

Regulatory Elements for H19 Gene

Proteins for H19 Gene

Post-translational modifications for H19 Gene

No Post-translational modifications

No data available for DME Specific Peptides for H19 Gene

Domains for H19 Gene

Gene Families for H19 Gene

HGNC:
  • LNCRNA :Long non-coding RNAs
genes like me logo Genes that share domains with H19: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for H19 Gene

Function for H19 Gene

Molecular function for H19 Gene

GENATLAS Biochemistry: DNA segment,single copy,probe H19S1,highly expressed in endodermal and mesodermal embryonic tissues,in adult brain,only in the pons and globus pallidus,paternally imprinted,(?same as ASMG),telomeric imprinting domain at 11p15,containing ASCL2,IGF2 and H19,silenced and hypermethylated in most Wilms tumor and in bladder carcinomas,but hypomethylated in benign ovarian teratoma
genes like me logo Genes that share phenotypes with H19: view

Animal Models for H19 Gene

MGI Knock Outs for H19:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for H19 Gene

Localization for H19 Gene

No data available for Gene Ontology (GO) - Cellular Components for H19 Gene

Pathways for H19 Gene

SuperPathways for H19 Gene

No Data Available

Interacting Proteins for H19 Gene

Gene Ontology (GO) - Biological Process for H19 Gene

None

No data available for Pathways by source for H19 Gene

Compounds for H19 Gene

(18) Novoseek inferred chemical compound relationships for H19 Gene

Compound -log(P) Hits PubMed IDs
nap-2 78.3 3
apai 73.6 7
rsai 68.4 8
cytosine 47.1 3
5-aza-2deoxycytidine 45.5 4
genes like me logo Genes that share compounds with H19: view

Transcripts for H19 Gene

Unigene Clusters for H19 Gene

H19, imprinted maternally expressed transcript (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for H19 Gene

No ASD Table

Relevant External Links for H19 Gene

GeneLoc Exon Structure for
H19
ECgene alternative splicing isoforms for
H19

Expression for H19 Gene

mRNA expression in normal human tissues for H19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for H19 Gene

This gene is overexpressed in Muscle - Skeletal (11.1) and Adrenal Gland (4.6).

SOURCE GeneReport for Unigene cluster for H19 Gene Hs.533566

genes like me logo Genes that share expressions with H19: view

Orthologs for H19 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for H19 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia H19 16
Species with no ortholog for H19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for H19 Gene

ENSEMBL:
Gene Tree for H19 (if available)
TreeFam:
Gene Tree for H19 (if available)

Paralogs for H19 Gene

No data available for Paralogs for H19 Gene

Variants for H19 Gene

Sequence variations from dbSNP and Humsavar for H19 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs217727 -- 1,995,678(-) TGCGG(C/T)GGACG nc-transcript-variant
rs2071095 -- 1,999,397(-) TACGG(G/T)GTGGG upstream-variant-2KB
rs2668850 -- 1,996,229(-) YGSCG(C/G/T)GCCAC intron-variant
rs2735969 -- 1,996,232(-) CCCYG(C/G)CGSGC intron-variant
rs2839701 -- 1,995,880(-) GCTCT(C/G)GAAGG nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for H19 Gene

Variant ID Type Subtype PubMed ID
nsv896727 CNV Gain 21882294
nsv896731 CNV Loss 21882294
nsv467645 CNV Gain 19166990
nsv469926 CNV Loss 18288195
dgv983n71 CNV Loss 21882294
esv29980 CNV Loss 17803354
nsv522320 CNV Loss 19592680
dgv987n71 CNV Loss 21882294
dgv988n71 CNV Loss 21882294
dgv989n71 CNV Loss 21882294
dgv991n71 CNV Loss 21882294
nsv896767 CNV Loss 21882294
nsv896768 CNV Gain 21882294
nsv896769 CNV Gain 21882294

Relevant External Links for H19 Gene

HapMap Linkage Disequilibrium report
H19
Human Gene Mutation Database (HGMD)
H19

Disorders for H19 Gene

(3) OMIM Diseases for H19 Gene (103280)

(62) Novoseek inferred disease relationships for H19 Gene

Disease -log(P) Hits PubMed IDs
beckwith-wiedemann syndrome 92.4 19
embryonal tumor 79.8 2
wilms tumor 79.7 31
cancer embryonal 79 1
pediatric germ cell tumor 65.8 1

Relevant External Links for H19

GeneTests
H19
GeneReviews
H19
Genetic Association Database (GAD)
H19
Human Genome Epidemiology (HuGE) Navigator
H19
genes like me logo Genes that share disorders with H19: view

No data available for UniProtKB/Swiss-Prot for H19 Gene

Publications for H19 Gene

  1. Polymorphisms in the H19 gene and the risk of bladder cancer. (PMID: 18262338) Verhaegh G.W. … Kiemeney L.A. (Eur. Urol. 2008) 3 23 49
  2. The H19 gene imprinting in normal pregnancy and pre-eclampsia. (PMID: 19342096) Yu L. … Li L. (Placenta 2009) 3 23 49
  3. Association of breast cancer susceptibility variants with risk of pancreatic cancer. (PMID: 19843670) Couch F.J. … Petersen G.M. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 23 49
  4. Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PMID: 20145138) Odefrey F. … Southey M.C. (Cancer Res. 2010) 3 49
  5. Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma. (PMID: 18604514) Grbesa I. … Gall-Troselj K. (J. Mol. Med. 2008) 3 23

Products for H19 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate H19
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for H19
    • Block miRNA regulation of H19 using miScript Target Protectors

    Sources for H19 Gene

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