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Aliases & Descriptions for GRPR gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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User Feedback Aliases & Descriptions gastrin-releasing peptide receptor1 2 GRP-R2 3 GRP-preferring bombesin receptor2 3
Search outside databases for aliases for GRPR genePrevious GC identifers: GC0XP015862 GC0XP014967 GC0XP015343 GC0XP015503 GC0XP015901
Summaries for GRPR gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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User Feedback Entrez Gene summary for GRPR : Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. (provided by RefSeq) UniProtKB/Swiss-Prot: GRPR_HUMAN, P30550 Function : Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with Gproteins that activate a phosphatidylinositol-calcium second messenger system summary
for GRPR : Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). Thereceptors are Gq/11-coupled and are involved in the regulation of many biological functions includingsensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may alsobe involved in tissue development, proliferation and differentiation. Gene Wiki entry for GRPR (Gastrin-releasing peptide receptor)
Genomic Views for GRPR gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
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Ensembl (release 56) ,
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User Feedback Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the GRPR gene upstream (promoter) region :p53 GATA-1 RFX1 POU2F1 NF-E2 p45 NF-E2 Cdc5 ITF-2 Tal-1beta FOXL1 Epigenetics: Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for GRPR Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xp22.2-p22.13 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.2 GRPR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP016051: view genomic region
(about GC identifiers )
Start:
16,141,424 bp from pter
End:
16,171,641 bp from pter
Size:
30,218 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000023.10 NT_167197.1 Proteins for GRPR gene
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene ,
Novus Biologicals , and/or
Sino Biological ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 May 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abnova ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
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User Feedback UniProtKB/Swiss-Prot: GRPR_HUMAN, P30550 (See
protein sequence )Recommended Name: Gastrin-releasing peptide receptor Size : 384 amino acids; 43199 Da
Subcellular location : Cell membrane; Multi-pass membrane protein
Secondary accessions : B2R910
REFSEQ proteins: NP_005305.1 ENSEMBL proteins: ENSP00000369643 Human Recombinant Proteins 3 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
GRPR for ontologies About GeneDecksing Antibodies for GRPR: Assays for GRPR:
Protein
Domains/ Families for GRPR gene(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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GRPR for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P30550 ProtoNet protein and cluster: P30550
2 Blocks protein families : IPB001556 Bombesin receptor signature IPB001966 Gastrin-releasing peptide receptor signature UniProtKB/Swiss-Prot: GRPR_HUMAN, P30550 Similarity : Belongs to the G-protein coupled receptor 1 family
Gene Function for GRPR gene
(According to MGI May 08 2010, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Millipore ,
Abnova ,
siRNAs from
Applied Biosystems ,
Sigma-Aldrich , Clones from
Millipore ,
Sigma-Aldrich ,
OriGene ,
Sino Biological ,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene .)
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User Feedback UniProtKB/Swiss-Prot: GRPR_HUMAN, P30550 Function : Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with Gproteins that activate a phosphatidylinositol-calcium second messenger system
Genatlas biochemistry entry for GRPR :gastrin releasing peptide receptor 5 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
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GRPR for ontologies About GeneDecksing Animal Models: 3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Grpr) :
GRPR for phenotypes About GeneDecksing Pathways & Interactions for GRPR gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
Applied Biosystems GeneAssist ,
KEGG
and/or UniProtKB ,
(map by GeneGo ),
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene) .
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GRPR for pathways About GeneDecksing 1 Millipore Pathway for GRPR 2 Kegg Pathways (Kegg details for GRPR) : hsa04020 Calcium signaling pathway hsa04080 Neuroactive ligand-receptor interaction
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRPR 5/43 Interacting proteins for GRPR (ENSP00000369643 3 ) via UniProtKB, MINT, and/or STRING (see all 43
) About this table 5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6
):
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GRPR for ontologies About GeneDecksing
Drugs & Compounds for GRPR gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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GRPR for compounds About GeneDecksing
Enzo Life Sciences drugs & compounds for GRPR
Compounds for GRPR available from Tocris Bioscience Compound Action
CAS
number Bombesin Involved in gastrointestinal tract function [31362-50-2] GRP (human) Endogenous GRP receptor agonist [93755-85-2] Neuromedin B (porcine) Mammalian bombesin-like peptide [87096-84-2] ICI 216,140 Potent Bombesin/Gastrin releasing peptide antagonist [124001-41-8] BIM 23127 NMB receptor antagonist. Also U-II receptor antagonist [160161-61-5]
About this table 10/54 Novoseek chemical compound relationships for GRPR gene (see all 54
)
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Transcripts for GRPR gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 223 Homo sapiens; Apr 2 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from SABiosciences ,
Tagged/untagged cDNA clones from
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Primers from
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User Feedback microRNA: 1 SABiosciences microRNA that regulate GRPR : hsa-miR-186
Assays: Applied Biosystems TaqMan® Gene Expression Assays: NM_005314 Clones: Origene GFP tagged cDNA clones in CMV expression vector: GRPR Origene Myc/DDK tagged cDNA clones in CMV expression vector: GRPR Origene untagged cDNA clones in CMV expression vector: GRPR
Primers: Origene genome-wide validated SYBR primer pairs: GRPR SABiosciences RT2 qPCR Primer Assay for GRPR: PPH09889A
REFSEQ mRNAs for GRPR gene: NM_005314.2
Additional cDNA sequence: AK313588.1 BC074733.2 M73481.1 U57365.1
2 DOTS entries : DT.304108 DT.102820776
12 AceView cDNA sequences :
BP357052 NM_005314 M73481 BC074733 BX280081 BP356908 AU125660 BG115453 BG216701 CD246196 U57365 AU149272
highest scoring ESTs for GRPR :M73481 AU125660 BG115453 BG216701 AU149272 BC074733 BP357052 BX280081 CD246196 NM_005314 Unigene Cluster for GRPR:
Gastrin-releasing peptide receptor Hs.567282 [show with all ESTs ] Unigene Representative Sequence: NM_005314 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000380289
Expression for GRPR gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 223 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems ,
Primers from
OriGene and/or
SABiosciences
)
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User Feedback GRPR expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for GRPR 1 / 2 / 3
3 probe-sets matching GRPR gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
32430_at2 , 3
U95-A
1
0.81
1.00
1.00
1.00
M73481
1.00
1.00
1.00
1
207929_at2 , 3
U133-A
1
0.73
1.00
--
--
NM_005314
0.60
1.00
0.82
1
207929_at2
U133Plus2
1
0.73
1.00
--
--
--
--
--
--
--
About this table
GRPR for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CTATTAATTA SOURCE GeneReport for Unigene cluster: Hs.567282 Expression variation in blood from EXPOLDB for GRPR
UniProtKB/Swiss-Prot: GRPR_HUMAN, P30550 Tissue specificity : Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain
Primers: Origene genome-wide validated SYBR primer pairs: GRPR SABiosciences RT2 qPCR Primer Assay for GRPR: PPH09889A
Orthologs for GRPR gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI May 08 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for GRPR gene from 5/10 species (see all 10
)
About this table Species with no ortholog for GRPR ENSEMBL Gene Tree for GRPR Paralogs for GRPR gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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User Feedback Paralogs for GRPR gene EDNRA 2 GPR37 2 EDNRB 2 BRS3 2 NMBR 2 GPR37L1 2
GRPR for paralogs About GeneDecksing
Genomic Variants for GRPR gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants ,
Genotyping Reagents from
Applied Biosystems )
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The following additional 61 SNP(s) have been
found in Applied Biosystems data source:(Click
for
Applied Biosystems TaqMan ® Genotyping Assay ) HapMap Linkage Disequilibrium images for GRPR (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for GRPR: --
Disorders & Mutations for GRPR gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
BCGD,
and/or TGDB .)
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GRPR for disorders About GeneDecksing
OMIM: 305670 10/93 Novoseek disease relationships for GRPR gene (see all 93
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
neuroblastoma
17.86
28
15300220 (7), 19426821 (6), 11981207 (5), 18753628 (4) (see all 8 )
prostate cancer
16.14
44
19876914 (5), 19343734 (5), 16631086 (4), 19398012 (3) (see all 25 )
sclc
13.51
19
12474049 (4), 12569606 (2), 11062732 (2), 9406683 (1) (see all 14 )
duodenal cancer
8.99
5
11245983 (3), 15361544 (1), 12220644 (1)
gastrointestinal carcinoid tumor
6.39
3
14747448 (3)
prostate tumor
5.06
5
19910427 (1), 19876914 (1), 19173600 (1), 18754574 (1) (see all 5 )
colon cancer
4.46
13
19519524 (3), 12720295 (3), 9366567 (2), 10211100 (2) (see all 7 )
neurodevelopmental disorder
3.83
3
17097693 (3)
adenocarcinoma gastric
3.39
4
10422879 (4)
gastrinoma
3.19
3
8943970 (3)
About this table Locus Specific Mutation Databases: GRPR Human Gene Mutation Database : GRPR Genetic Association Database: GRPR Human Genome Epidemiology Navigator: GRPR (7 documents)
Medical News for GRPR gene (Possibly Related Articles in
Doctor's Guide )
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Publications for GRPR gene (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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User Feedback 10/220 PubMed articles for GRPR gene (see all 220
): The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. (PubMed id 11245983) 1, 3 , 4 Xiao D.... Weber H.C. (2001) Gastrin-releasing peptide receptor (GRPR) locus in Japanese subjects with autism. (PubMed id 14729406) 1, 3 , 6 Marui T....Sasaki T. (2004) Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. (PubMed id 1655761) 1, 3 , 4 Corjay M.H.... Battey J.F. (1991) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3 , 4 Gerhard D.S....Malek J. (2004) Alterations in receptor expression or agonist concentration change the pathways gastrin-releasing peptide receptor uses to regulate extracellular signal-regulated kinase. (PubMed id 15361544) 1, 3 Chen P.W. and Kroog G.S. (2004) Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer. (PubMed id 10620630) 1, 3 Shriver S.P....Siegfried J.M. (2000) Gastrin-releasing peptide receptor silencing suppresses the tumorigenesis and metastatic potential of neuroblastoma. (PubMed id 18753628) 1, 3 Qiao J....Chung D.H. (2008) Gastrin-releasing peptide receptor in breast cancer m ediates cellular migration and interleukin-8 expression. (PubMed id 19631337) 1, 3 Chao C....Hellmich M.R. (year=2009;month=Sep;day=) Gastrin-releasing peptide receptor expression in cervical cancer. (PubMed id 18497507) 1, 3 Baumann Cornelio D....Schwartsmann G. (2007) Increased frequency of gastrin-releasing peptide receptor gene mutations during colon-adenocarcinoma progression. (PubMed id 12720295) 1, 3 Glover S.C....Benya R.V. (2003)
Search for GRPR gene
(in PubMed ,
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Genome Databases showing GRPR gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing GRPR gene
(According to HUGE )
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Specialized Databases showing GRPR gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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User Feedback Patent Information for GRPR gene: Search GeneIP for patents involving GRPR GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search Services for GRPR gene (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Novus Biologicals ,Epitomics , Sigma-Aldrich , R&D Systems , SABiosciences , Millipore , Abnova , Clones available from OriGene , Sigma-Aldrich , Sino Biological , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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User Feedback Products for GRPR:
Tocris compounds for GRPR
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Aliases for GRPR
Databases for GRPR
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