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Aliases for GZMM Gene

Aliases for GZMM Gene

  • Granzyme M (Lymphocyte Met-Ase 1) 2 3
  • Natural Killer Cell Granular Protease 3 4
  • Met-1 Serine Protease 3 4
  • Lymphocyte Met-Ase 1 2 3
  • HU-Met-1 3 4
  • Met-Ase 3 4
  • MET1 3 4
  • EC 3.4.21.- 4
  • Granzyme M 3
  • EC 3.4.21 64
  • LMET1 3

External Ids for GZMM Gene

Summaries for GZMM Gene

Entrez Gene Summary for GZMM Gene

  • Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for GZMM Gene

GZMM (Granzyme M (Lymphocyte Met-Ase 1)) is a Protein Coding gene. Among its related pathways are Creation of C4 and C2 activators and Creation of C4 and C2 activators. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ELANE.

UniProtKB/Swiss-Prot for GZMM Gene

  • Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.

Gene Wiki entry for GZMM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZMM Gene

Genomics for GZMM Gene

Genomic Location for GZMM Gene

Start:
544,034 bp from pter
End:
549,924 bp from pter
Size:
5,891 bases
Orientation:
Plus strand

Genomic View for GZMM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GZMM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZMM Gene

Regulatory Elements for GZMM Gene

Proteins for GZMM Gene

  • Protein details for GZMM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51124-GRAM_HUMAN
    Recommended name:
    Granzyme M
    Protein Accession:
    P51124
    Secondary Accessions:

    Protein attributes for GZMM Gene

    Size:
    257 amino acids
    Molecular mass:
    27545 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GZMM Gene

neXtProt entry for GZMM Gene

Proteomics data for GZMM Gene at MOPED

Selected DME Specific Peptides for GZMM Gene

Post-translational modifications for GZMM Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn177

Other Protein References for GZMM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GZMM Gene

UniProtKB/Swiss-Prot:

GRAM_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • P51124
Family:
  • Belongs to the peptidase S1 family. Granzyme subfamily.:
    • P51124
genes like me logo Genes that share domains with GZMM: view

No data available for Gene Families for GZMM Gene

Function for GZMM Gene

Molecular function for GZMM Gene

GENATLAS Biochemistry: natural killer cells granule serine protease,cleaving after methionine (Met-ase)
UniProtKB/Swiss-Prot Function: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.

Enzyme Numbers (IUBMB) for GZMM Gene

Gene Ontology (GO) - Molecular Function for GZMM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004175 endopeptidase activity --
GO:0004252 serine-type endopeptidase activity IMP 21857942
GO:0005515 protein binding IPI 21857942
GO:0008236 serine-type peptidase activity TAS 7713495
genes like me logo Genes that share ontologies with GZMM: view
genes like me logo Genes that share phenotypes with GZMM: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GZMM Gene

Localization for GZMM Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZMM Gene

Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GZMM Gene COMPARTMENTS Subcellular localization image for GZMM gene
Compartment Confidence
extracellular 5
nucleus 2
chloroplast 1
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GZMM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GZMM: view

Pathways for GZMM Gene

genes like me logo Genes that share pathways with GZMM: view

Pathways by source for GZMM Gene

1 Qiagen pathway for GZMM Gene

Gene Ontology (GO) - Biological Process for GZMM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006915 apoptotic process IEA --
GO:0008219 cell death IMP 21857942
GO:0019835 cytolysis IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with GZMM: view

Compounds for GZMM Gene

(1) Novoseek inferred chemical compound relationships for GZMM Gene

Compound -log(P) Hits PubMed IDs
serine 61.8 10
genes like me logo Genes that share compounds with GZMM: view

Transcripts for GZMM Gene

mRNA/cDNA for GZMM Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GZMM Gene

Granzyme M (lymphocyte met-ase 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GZMM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2:

Relevant External Links for GZMM Gene

GeneLoc Exon Structure for
GZMM
ECgene alternative splicing isoforms for
GZMM

Expression for GZMM Gene

mRNA expression in normal human tissues for GZMM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GZMM Gene

This gene is overexpressed in Whole Blood (34.6) and Spleen (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GZMM Gene

SOURCE GeneReport for Unigene cluster for GZMM Gene Hs.465511

mRNA Expression by UniProt/SwissProt for GZMM Gene

P51124-GRAM_HUMAN
Tissue specificity: Highly and constitutively expressed in activated natural killer (NK) cells.
genes like me logo Genes that share expressions with GZMM: view

Orthologs for GZMM Gene

This gene was present in the common ancestor of chordates.

Orthologs for GZMM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GZMM 36
  • 77.4 (n)
  • 72.1 (a)
GZMM 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gzmm 36
  • 74.07 (n)
  • 70.63 (a)
Gzmm 16
Gzmm 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GZMM 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gzmm 36
  • 73.94 (n)
  • 69.84 (a)
chicken
(Gallus gallus)
Aves GZMM 36
  • 62.81 (n)
  • 52.07 (a)
GZMM 37
  • 39 (a)
OneToOne
Species with no ortholog for GZMM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GZMM Gene

ENSEMBL:
Gene Tree for GZMM (if available)
TreeFam:
Gene Tree for GZMM (if available)

Paralogs for GZMM Gene

Paralogs for GZMM Gene

genes like me logo Genes that share paralogs with GZMM: view

Variants for GZMM Gene

Sequence variations from dbSNP and Humsavar for GZMM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs892209 -- 544,140(+) GAGCC(A/G)GGATG intron-variant
rs1599883 -- 549,595(-) TCTGC(A/G)CCTGC intron-variant
rs1599884 -- 549,492(-) ACGCG(C/T)GTCCC intron-variant
rs2070794 -- 547,483(+) CATCC(A/G)ACGGC intron-variant
rs2070795 -- 547,491(+) GGCGC(C/T)CATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GZMM Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
dgv3498n71 CNV Loss 21882294
dgv3505n71 CNV Loss 21882294
nsv910102 CNV Loss 21882294
nsv910109 CNV Loss 21882294
nsv509712 CNV Insertion 20534489
nsv470101 CNV Loss 18288195
dgv3507n71 CNV Loss 21882294
nsv910119 CNV Gain 21882294
dgv3508n71 CNV Loss 21882294
nsv910132 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3511n71 CNV Loss 21882294
nsv910137 CNV Loss 21882294
dgv3512n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3514n71 CNV Gain 21882294
dgv3515n71 CNV Loss 21882294
esv2661476 CNV Deletion 23128226
esv2656977 CNV Deletion 23128226

Relevant External Links for GZMM Gene

HapMap Linkage Disequilibrium report
GZMM

Disorders for GZMM Gene

(1) University of Copenhagen DISEASES for GZMM Gene

(2) Novoseek inferred disease relationships for GZMM Gene

Disease -log(P) Hits PubMed IDs
tumors 19.9 6
leukemia 6.57 1
genes like me logo Genes that share disorders with GZMM: view

No data available for UniProtKB/Swiss-Prot for GZMM Gene

Publications for GZMM Gene

  1. The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. (PMID: 7713495) Pilat D. … Jenne D.E. (Genomics 1994) 3 4 23
  2. Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells. (PMID: 8245461) Smyth M.J. … Trapani J.A. (J. Immunol. 1993) 3 4 23
  3. Structural basis for proteolytic specificity of the human apoptosis- inducing granzyme M. (PMID: 19542453) Wu L. … Fan Z. (J. Immunol. 2009) 3 4 23
  4. Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells. (PMID: 20406824) Hu D. … Fan Z. (J. Biol. Chem. 2010) 3 4 23
  5. The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3. (PMID: 8119738) Baker E. … Smyth M.J. (Immunogenetics 1994) 2 3

Products for GZMM Gene

Sources for GZMM Gene

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