Aliases for GZMM Gene
External Ids for GZMM Gene
Previous GeneCards Identifiers for GZMM Gene
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for GZMM Gene
GZMM (Granzyme M (Lymphocyte Met-Ase 1)) is a Protein Coding gene. Among its related pathways are Immune System and Creation of C4 and C2 activators. GO annotations related to this gene include serine-type endopeptidase activity and endopeptidase activity. An important paralog of this gene is ELANE.
UniProtKB/Swiss-Prot for GZMM Gene
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.