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Aliases for GZMM Gene

Aliases for GZMM Gene

  • Granzyme M 2 3 5
  • Natural Killer Cell Granular Protease 3 4
  • Granzyme M (Lymphocyte Met-Ase 1) 2 3
  • Met-1 Serine Protease 3 4
  • Lymphocyte Met-Ase 1 2 3
  • HU-Met-1 3 4
  • Met-Ase 3 4
  • MET1 3 4
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • LMET1 3

External Ids for GZMM Gene

Previous GeneCards Identifiers for GZMM Gene

  • GC19P000554
  • GC19P000579
  • GC19P000484
  • GC19P000495
  • GC19P000314

Summaries for GZMM Gene

Entrez Gene Summary for GZMM Gene

  • Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for GZMM Gene

GZMM (Granzyme M) is a Protein Coding gene. Among its related pathways are Immune System and Creation of C4 and C2 activators. GO annotations related to this gene include serine-type endopeptidase activity and endopeptidase activity. An important paralog of this gene is ELANE.

UniProtKB/Swiss-Prot for GZMM Gene

  • Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.

Gene Wiki entry for GZMM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZMM Gene

Genomics for GZMM Gene

Regulatory Elements for GZMM Gene

Promoters for GZMM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GZMM on UCSC Golden Path with GeneCards custom track

Genomic Location for GZMM Gene

Chromosome:
19
Start:
544,034 bp from pter
End:
549,924 bp from pter
Size:
5,891 bases
Orientation:
Plus strand

Genomic View for GZMM Gene

Genes around GZMM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GZMM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GZMM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZMM Gene

Proteins for GZMM Gene

  • Protein details for GZMM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51124-GRAM_HUMAN
    Recommended name:
    Granzyme M
    Protein Accession:
    P51124

    Protein attributes for GZMM Gene

    Size:
    257 amino acids
    Molecular mass:
    27545 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GZMM Gene

neXtProt entry for GZMM Gene

Proteomics data for GZMM Gene at MOPED

Selected DME Specific Peptides for GZMM Gene

Post-translational modifications for GZMM Gene

  • Glycosylation at Asn 177
  • Modification sites at PhosphoSitePlus

Other Protein References for GZMM Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GZMM Gene

Suggested Antigen Peptide Sequences for GZMM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51124

UniProtKB/Swiss-Prot:

GRAM_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Granzyme subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Granzyme subfamily.
genes like me logo Genes that share domains with GZMM: view

No data available for Gene Families for GZMM Gene

Function for GZMM Gene

Molecular function for GZMM Gene

GENATLAS Biochemistry:
natural killer cells granule serine protease,cleaving after methionine (Met-ase)
UniProtKB/Swiss-Prot Function:
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.

Enzyme Numbers (IUBMB) for GZMM Gene

genes like me logo Genes that share phenotypes with GZMM: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GZMM Gene

Localization for GZMM Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZMM Gene

Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GZMM Gene COMPARTMENTS Subcellular localization image for GZMM gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
chloroplast 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for GZMM Gene

Pathways & Interactions for GZMM Gene

genes like me logo Genes that share pathways with GZMM: view

Pathways by source for GZMM Gene

Gene Ontology (GO) - Biological Process for GZMM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with GZMM: view

No data available for SIGNOR curated interactions for GZMM Gene

Drugs & Compounds for GZMM Gene

(1) Drugs for GZMM Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GZMM: view

Transcripts for GZMM Gene

mRNA/cDNA for GZMM Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GZMM Gene

Granzyme M (lymphocyte met-ase 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GZMM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2:

Relevant External Links for GZMM Gene

GeneLoc Exon Structure for
GZMM
ECgene alternative splicing isoforms for
GZMM

Expression for GZMM Gene

mRNA expression in normal human tissues for GZMM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GZMM Gene

This gene is overexpressed in Whole Blood (x34.6) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for GZMM Gene

This gene is overexpressed in NK cells (30.2), CD8 Tcells (11.9), Peripheral blood mononuclear cells (11.5), Monocytes (6.9), and Blymphocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GZMM Gene



SOURCE GeneReport for Unigene cluster for GZMM Gene Hs.465511

mRNA Expression by UniProt/SwissProt for GZMM Gene

P51124-GRAM_HUMAN
Tissue specificity: Highly and constitutively expressed in activated natural killer (NK) cells.
genes like me logo Genes that share expression patterns with GZMM: view

Protein tissue co-expression partners for GZMM Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for GZMM Gene

This gene was present in the common ancestor of chordates.

Orthologs for GZMM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GZMM 35
  • 77.4 (n)
  • 72.1 (a)
GZMM 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gzmm 35
  • 74.07 (n)
  • 70.63 (a)
Gzmm 16
Gzmm 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gzmm 35
  • 73.94 (n)
  • 69.84 (a)
oppossum
(Monodelphis domestica)
Mammalia GZMM 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves GZMM 35
  • 62.81 (n)
  • 52.07 (a)
GZMM 36
  • 39 (a)
OneToOne
Species with no ortholog for GZMM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GZMM Gene

ENSEMBL:
Gene Tree for GZMM (if available)
TreeFam:
Gene Tree for GZMM (if available)

Paralogs for GZMM Gene

Paralogs for GZMM Gene

genes like me logo Genes that share paralogs with GZMM: view

Variants for GZMM Gene

Sequence variations from dbSNP and Humsavar for GZMM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1599882 - 549,678(-) GACTC(C/T)GGCCA reference, missense
rs892209 -- 544,140(+) GAGCC(A/G)GGATG intron-variant
rs1599883 -- 549,595(-) TCTGC(A/G)CCTGC intron-variant
rs1599884 -- 549,492(-) ACGCG(C/T)GTCCC intron-variant
rs2070794 -- 547,483(+) CATCC(A/G)ACGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GZMM Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
dgv3498n71 CNV Loss 21882294
dgv3505n71 CNV Loss 21882294
nsv910102 CNV Loss 21882294
nsv910109 CNV Loss 21882294
nsv509712 CNV Insertion 20534489
nsv470101 CNV Loss 18288195
dgv3507n71 CNV Loss 21882294
nsv910119 CNV Gain 21882294
dgv3508n71 CNV Loss 21882294
nsv910132 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3511n71 CNV Loss 21882294
nsv910137 CNV Loss 21882294
dgv3512n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3514n71 CNV Gain 21882294
dgv3515n71 CNV Loss 21882294
esv2661476 CNV Deletion 23128226
esv2656977 CNV Deletion 23128226

Variation tolerance for GZMM Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GZMM Gene

HapMap Linkage Disequilibrium report
GZMM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GZMM Gene

Disorders for GZMM Gene

Relevant External Links for GZMM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GZMM

No disorders were found for GZMM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GZMM Gene

Publications for GZMM Gene

  1. Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells. (PMID: 20406824) Hu D. … Fan Z. (J. Biol. Chem. 2010) 3 4 23 67
  2. Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing. (PMID: 19103589) Cullen S.P. … Martin S.J. (J. Biol. Chem. 2009) 3 23
  3. Structural basis for proteolytic specificity of the human apoptosis- inducing granzyme M. (PMID: 19542453) Wu L. … Fan Z. (J. Immunol. 2009) 3 23
  4. Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation. (PMID: 16818775) Lu H. … Fan Z. (J. Immunol. 2006) 3 23
  5. Granzyme M mediates a novel form of perforin-dependent cell death. (PMID: 15028722) Kelly J.M. … Smyth M.J. (J. Biol. Chem. 2004) 3 23

Products for GZMM Gene

Sources for GZMM Gene

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