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GZMM Gene

protein-coding   GIFtS: 58
GCID: GC19P000544

Granzyme M (Lymphocyte Met-Ase 1)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Granzyme M (Lymphocyte Met-Ase 1)1 2     Granzyme M2
Lymphocyte Met-Ase 11 2     met-ase2
Natural Killer Cell Granular Protease2 3     EC 3.4.21.-3
MET12 3     Hu-Met-13
Met-1 Serine Protease2 3     Met-ase3
HU-Met-12     EC 3.4.218
LMET12     

External Ids:    HGNC: 47121   Entrez Gene: 30042   Ensembl: ENSG000001975407   OMIM: 6003115   UniProtKB: P511243   

Export aliases for GZMM gene to outside databases

Previous GC identifers: GC19P000554 GC19P000579 GC19P000484 GC19P000495 GC19P000314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GZMM Gene:
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine
proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These
serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B,
granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for GZMM Gene:
GZMM (granzyme M (lymphocyte met-ase 1)) is a protein-coding gene. Diseases associated with GZMM include arrhythmogenic right ventricular dysplasia, and leukemia. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: GRAM_HUMAN, P51124
Function: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include
EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent
apoptosis of target cells

Gene Wiki entry for GZMM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the GZMM gene promoter:
         ATF-2   MyoD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGZMM promoter sequence
   Search Chromatin IP Primers for GZMM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GZMM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

GZMM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GZMM gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000544:  view genomic region     (about GC identifiers)

Start:
544,027 bp from pter      End:
549,919 bp from pter
Size:
5,893 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GRAM_HUMAN, P51124 (See protein sequence)
Recommended Name: Granzyme M precursor  
Size: 257 amino acids; 27545 Da
5 PDB 3D structures from and Proteopedia for GZMM:
1LZP (3D)        2ZGC (3D)        2ZGH (3D)        2ZGJ (3D)        2ZKS (3D)    

Explore the universe of human proteins at neXtProt for GZMM: NX_P51124

Explore proteomics data for GZMM at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn177
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GZMM (P51124) (see all 8)
     DLALLQL  CGGVLVH  SGGPLVC  GDSGGPL 


    See GZMM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001245280.1  NP_005308.1  

    ENSEMBL proteins: 
     ENSP00000476255   ENSP00000264553  
    Reactome Protein details: P51124

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    Cloud-Clone Corp. CLIAs for GZMM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P51124

    ProtoNet protein and cluster: P51124

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: GRAM_HUMAN, P51124
    Similarity: Belongs to the peptidase S1 family. Granzyme subfamily
    Similarity: Contains 1 peptidase S1 domain


    GZMM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRAM_HUMAN, P51124
    Function: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include
    EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent
    apoptosis of target cells

         Genatlas biochemistry entry for GZMM:
    natural killer cells granule serine protease,cleaving after methionine (Met-ase)

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004175endopeptidase activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008236serine-type peptidase activity TAS7713495
         
    GZMM for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GZMM:
     Decreased BPV1 E2 protein expr  Decreased cell number and incr  Increased G1 DNA content  Increased HPV18 LCR reporter a 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gzmm):
     immune system 

    GZMM for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GZMM
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GZMM
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    GenScript: all cDNA clones in your preferred vector: GZMM (NM_005317)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GZMM

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRAM_HUMAN, P51124: Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    chloroplast1
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    GZMM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GZMM About    
    See pathways by source

    SuperPathContained pathways About
    1Creation of C4 and C2 activators
    Initial triggering of complement0.85
    Alternative complement activation0.00
    Complement cascade0.68
    2Granzyme Pathway
    Granzyme Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GZMM
        Granzyme Pathway

    1 Reactome Pathway for GZMM
        Alternative complement activation



    GZMM for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GZMM
    Interactions:

        Search GeneGlobe Interaction Network for GZMM

    Selected Interacting proteins for GZMM (P511243) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP3P425743I2D: score=1 
    DFFAO002733I2D: score=1 
    EZRP153113I2D: score=1 
    NPM1P067483I2D: score=1 
    PAK2Q131773I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006915apoptotic process IEA--
    GO:0019835cytolysis IEA--
    GO:0045087innate immune response IEA--

    GZMM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GZMM (GRAM)

    1 Novoseek inferred chemical compound relationship for GZMM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 61.8 14 14725853 (2), 7713495 (2), 8245461 (1), 12506019 (1) (see all 8)



    GZMM for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GZMM gene (2 alternative transcripts): 
    NM_001258351.1  NM_005317.3  

    Unigene Cluster for GZMM:

    Granzyme M (lymphocyte met-ase 1)
    Hs.465511  [show with all ESTs]
    Unigene Representative Sequence: NM_005317
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592501 ENST00000264553(uc002low.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GZMM
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GZMM
      QuantiTect SYBR Green Assays in human, mouse, rat GZMM
      QuantiFast Probe-based Assays in human, mouse, rat GZMM

    Additional mRNA sequence: 

    BC025701.1 L23134.1 

    1 DOTS entry:

    DT.400411 

    12 AceView cDNA sequences:

    BC025701 BI838272 CD366947 BI823094 L23134 NM_005317 BI835971 BM987422 
    AW044312 AI910778 AI124941 T91241 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GZMM    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                                          


    ECgene alternative splicing isoforms for GZMM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GZMM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGCCTGG
    GZMM Expression
    About this image


    GZMM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    GZMM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GZMM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465511

    UniProtKB/Swiss-Prot: GRAM_HUMAN, P51124
    Tissue specificity: Highly and constitutively expressed in activated natural killer (NK) cells

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GZMM gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gzmm1 , 5 granzyme M (lymphocyte met-ase 1)1, 5 74.07(n)1
    70.63(a)1
      10 (39.72 cM)5
    169041  NM_008504.21  NP_032530.11 
     796890205 
    chicken
    (Gallus gallus)
    Aves GZMM1 granzyme M (lymphocyte met-ase 1) 62.81(n)
    52.07(a)
      100859124  XM_003642876.2  XP_003642924.2 


    ENSEMBL Gene Tree for GZMM (if available)
    TreeFam Gene Tree for GZMM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GZMM gene
    GZMH2  PRTN32  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  
    AZU12  GZMA2  GZMB2  
    Selected SIMAP similar genes for GZMM using alignment to 2 protein entries:     GRAM_HUMAN (see all proteins) (see all similar genes):
    KLK8    KLK4    PRSS57    DF    CFD    CELA3A
    PRSSL1    PRSS1    GZMK    F12    CTSG    KLK5
    CTRB1    CTRB2    CTRL    KLK9    CELA1    ELANE

    GZMM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GZMM (see all 332)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs169906721,2
    C,F--312063(+) AAACTA/GCTTTA 2 -- us2k12Minor allele frequency- G:0.02NS WA 294
    rs1830077971,2
    --312218(+) GTCCCA/GCGGCC 2 -- us2k10--------
    rs38103551,2
    C,F,H--312219(-) AGGCCG/ACGGGA 2 -- us2k16Minor allele frequency- A:0.01EA NS 1830
    rs169906761,2
    C,F--312228(+) CTGTAC/GGTTCC 2 -- us2k13Minor allele frequency- G:0.05NS WA 296
    rs169906801,2
    C,F--312243(+) ACTTGG/AGTCAG 2 -- us2k1 tfbs31Minor allele frequency- A:0.01NS 176
    rs169906841,2
    C,F--312325(+) GTGACC/TAGGTG 2 -- us2k11Minor allele frequency- T:0.01NS 176
    rs38268911,2
    C,F,H--312381(-) ACCCGC/TGACGA 2 -- us2k114Minor allele frequency- T:0.06NA NS EA WA 1090
    rs1446338441,2
    --312447(+) CCCCCA/GATCAG 2 -- us2k10--------
    rs169906901,2
    C--312451(+) CGATCA/CGCACT 2 -- us2k11Minor allele frequency- C:0.01NS 176
    rs37608801,2
    C,F,H--312459(-) GCCGCC/AGGAGT 2 -- us2k119Minor allele frequency- A:0.05EA NS NA WA 3862

    HapMap Linkage Disequilibrium report for GZMM (544027 - 549919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GZMM (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661476CNV Deletion23128226
    esv2656977CNV Deletion23128226
    nsv509712CNV Insertion20534489
    nsv470101CNV Loss18288195
    dgv3515n71CNV Loss21882294
    dgv3498n71CNV Loss21882294
    nsv910109CNV Loss21882294
    dgv3507n71CNV Loss21882294
    nsv910102CNV Loss21882294
    dgv3511n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GZMM
    DNA2.0 Custom Variant and Variant Library Synthesis for GZMM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600311    OMIM disorders: --

    2 diseases for GZMM:    
    About MalaCards
    arrhythmogenic right ventricular dysplasia    leukemia

    1 disease from the University of Copenhagen DISEASES database for GZMM:
    Arrhythmogenic right ventricular dysplasia

    GZMM for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for GZMM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 19.9 8 20406824 (2), 19673685 (1), 16219538 (1), 19542453 (1) (see all 5)
    leukemia 6.57 1 8245461 (1)


    Export disorders for GZMM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GZMM gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with GZMM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells. (PubMed id 20406824)1, 2, 9 Hu D.... Fan Z. (J. Biol. Chem. 2010)
    2. Structural basis for proteolytic specificity of the human apoptosis- inducing granzyme M. (PubMed id 19542453)1, 2, 9 Wu L....Fan Z. (J. Immunol. 2009)
    3. Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells. (PubMed id 8245461)1, 2, 9 Smyth M.J.... Trapani J.A. (J. Immunol. 1993)
    4. The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. (PubMed id 7713495)1, 2, 9 Pilat D.... Jenne D.E. (Genomics 1994)
    5. NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network. (PubMed id 18523284)1, 2 Bovenschen N.... Kummer J.A. (J. Immunol. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3. (PubMed id 8119738)1, 3 Baker E....Smyth M.J. (Immunogenetics 1994)
    8. Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B. (PubMed id 15494398)1, 9 Mahrus S....Craik C.S. (J. Biol. Chem. 2004)
    9. Granzyme M mediates a novel form of perforin-dependent cell death. (PubMed id 15028722)1, 9 Kelly J.M....Smyth M.J. (J. Biol. Chem. 2004)
    10. Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing. (PubMed id 19103589)1, 9 Cullen S.P....Martin S.J. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3004 HGNC: 4712 AceView: GZMM Ensembl:ENSG00000197540 euGenes: HUgn3004
    ECgene: GZMM H-InvDB: GZMM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GZMM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GZMM gene:
    Search GeneIP for patents involving GZMM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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