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Aliases for GZMK Gene

Aliases for GZMK Gene

  • Granzyme K 2 3 5
  • Granzyme K (Serine Protease, Granzyme 3; Tryptase II) 2 3
  • Granzyme K (Granzyme 3; Tryptase II) 2 3
  • NK-Tryptase-2 3 4
  • Fragmentin-3 3 4
  • Tryptase II 2 3
  • Granzyme-3 3 4
  • NK-Tryp-2 3 4
  • TRYP2 3 4
  • EC 3.4.21.4 61
  • EC 3.4.21.- 4
  • Granzyme 3 3
  • EC 3.4.21 61

External Ids for GZMK Gene

Previous GeneCards Identifiers for GZMK Gene

  • GC05P054483
  • GC05P055748
  • GC05P054290
  • GC05P054335
  • GC05P054355
  • GC05P054320
  • GC05P051293

Summaries for GZMK Gene

Entrez Gene Summary for GZMK Gene

  • This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GZMK Gene

GZMK (Granzyme K) is a Protein Coding gene. Diseases associated with GZMK include Arts Syndrome. Among its related pathways are Granzyme Pathway. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is GZMA.

Gene Wiki entry for GZMK Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZMK Gene

Genomics for GZMK Gene

Regulatory Elements for GZMK Gene

Enhancers for GZMK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GZMK on UCSC Golden Path with GeneCards custom track

Genomic Location for GZMK Gene

Chromosome:
5
Start:
55,024,253 bp from pter
End:
55,034,570 bp from pter
Size:
10,318 bases
Orientation:
Plus strand

Genomic View for GZMK Gene

Genes around GZMK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GZMK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GZMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZMK Gene

Proteins for GZMK Gene

  • Protein details for GZMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49863-GRAK_HUMAN
    Recommended name:
    Granzyme K
    Protein Accession:
    P49863
    Secondary Accessions:
    • B2R563

    Protein attributes for GZMK Gene

    Size:
    264 amino acids
    Molecular mass:
    28882 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GZMK Gene

neXtProt entry for GZMK Gene

Selected DME Specific Peptides for GZMK Gene

Post-translational modifications for GZMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GZMK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GZMK Gene

Suggested Antigen Peptide Sequences for GZMK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49863

UniProtKB/Swiss-Prot:

GRAK_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Granzyme subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Granzyme subfamily.
genes like me logo Genes that share domains with GZMK: view

No data available for Gene Families for GZMK Gene

Function for GZMK Gene

Enzyme Numbers (IUBMB) for GZMK Gene

Gene Ontology (GO) - Molecular Function for GZMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 8656064
genes like me logo Genes that share ontologies with GZMK: view
genes like me logo Genes that share phenotypes with GZMK: view

Animal Model Products

CRISPR Products

miRNA for GZMK Gene

miRTarBase miRNAs that target GZMK

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GZMK Gene

Localization for GZMK Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZMK Gene

Secreted. Cytoplasmic granule.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GZMK Gene COMPARTMENTS Subcellular localization image for GZMK gene
Compartment Confidence
extracellular 5
chloroplast 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GZMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GZMK: view

Pathways & Interactions for GZMK Gene

SuperPathways for GZMK Gene

Superpath Contained pathways
1 Granzyme Pathway
genes like me logo Genes that share pathways with GZMK: view

Pathways by source for GZMK Gene

1 Qiagen pathway for GZMK Gene

Gene Ontology (GO) - Biological Process for GZMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with GZMK: view

No data available for SIGNOR curated interactions for GZMK Gene

Drugs & Compounds for GZMK Gene

(3) Drugs for GZMK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GZMK: view

Transcripts for GZMK Gene

mRNA/cDNA for GZMK Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GZMK Gene

Granzyme K (granzyme 3; tryptase II):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GZMK Gene

No ASD Table

Relevant External Links for GZMK Gene

GeneLoc Exon Structure for
GZMK
ECgene alternative splicing isoforms for
GZMK

Expression for GZMK Gene

mRNA expression in normal human tissues for GZMK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GZMK Gene

This gene is overexpressed in Whole Blood (x17.6) and Spleen (x11.7).

Protein differential expression in normal tissues from HIPED for GZMK Gene

This gene is overexpressed in CD8 Tcells (21.7), Peripheral blood mononuclear cells (18.7), Tlymphocyte (12.4), and NK cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GZMK Gene



Protein tissue co-expression partners for GZMK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GZMK Gene:

GZMK

SOURCE GeneReport for Unigene cluster for GZMK Gene:

Hs.277937

mRNA Expression by UniProt/SwissProt for GZMK Gene:

P49863-GRAK_HUMAN
Tissue specificity: Expressed in lung, spleen, thymus and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with GZMK: view

Primer Products

Orthologs for GZMK Gene

This gene was present in the common ancestor of chordates.

Orthologs for GZMK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GZMK 34
  • 81.31 (n)
  • 72.73 (a)
GZMK 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GZMK 34
  • 80.56 (n)
  • 72.35 (a)
GZMK 35
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gzmk 34
  • 78.29 (n)
  • 73.26 (a)
Gzmk 16
Gzmk 35
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GZMK 34
  • 99.62 (n)
  • 99.24 (a)
GZMK 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gzmk 34
  • 78.44 (n)
  • 73.41 (a)
chicken
(Gallus gallus)
Aves GZMK 35
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gzma 34
  • 52.12 (n)
  • 42.37 (a)
gzma 35
  • 37 (a)
OneToMany
gzmk 35
  • 36 (a)
OneToMany
Species where no ortholog for GZMK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GZMK Gene

ENSEMBL:
Gene Tree for GZMK (if available)
TreeFam:
Gene Tree for GZMK (if available)

Paralogs for GZMK Gene

Paralogs for GZMK Gene

genes like me logo Genes that share paralogs with GZMK: view

Variants for GZMK Gene

Sequence variations from dbSNP and Humsavar for GZMK Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1848502 -- 55,026,648(+) GTTTG(C/G)CCCAA intron-variant
rs1858083 -- 55,029,817(-) GCCAC(C/T)TGGGA intron-variant
rs2112938 -- 55,032,127(-) ataag(A/C)caccg intron-variant
rs4865911 -- 55,029,092(+) TAGCC(A/G)GGTGT intron-variant
rs17681401 -- 55,034,085(+) ACTGA(C/T)GTATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GZMK Gene

Variant ID Type Subtype PubMed ID
nsv830301 CNV gain 17160897

Variation tolerance for GZMK Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GZMK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GZMK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GZMK Gene

Disorders for GZMK Gene

MalaCards: The human disease database

(1) MalaCards diseases for GZMK Gene - From: DISEASES

Disorder Aliases PubMed IDs
arts syndrome
  • lethal ataxia with deafness and optic atrophy
- elite association - COSMIC cancer census association via MalaCards
Search GZMK in MalaCards View complete list of genes associated with diseases

Relevant External Links for GZMK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GZMK
genes like me logo Genes that share disorders with GZMK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GZMK Gene

Publications for GZMK Gene

  1. Cloning of cDNA for human granzyme 3. (PMID: 7758581) Przetak M.M. … Schmidt B.F. (FEBS Lett. 1995) 2 3 4 22 65
  2. The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. (PMID: 12384499) Hink-Schauer C. … Jenne D.E. (J. Biol. Chem. 2002) 3 4 22 65
  3. Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. (PMID: 8656064) Sayers T.J. … Smyth M.J. (J. Leukoc. Biol. 1996) 3 4 22 65
  4. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. (PMID: 1460416) Shi L. … Greenberg A.H. (J. Exp. Med. 1992) 3 4 22 65
  5. Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. (PMID: 19059912) Bovenschen N. … Kummer J.A. (J. Biol. Chem. 2009) 3 22 65

Products for GZMK Gene

Sources for GZMK Gene

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