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Aliases for GZMK Gene

Aliases for GZMK Gene

  • Granzyme K 2 3 5
  • Granzyme K (Serine Protease, Granzyme 3; Tryptase II) 2 3
  • Granzyme K (Granzyme 3; Tryptase II) 2 3
  • NK-Tryptase-2 3 4
  • Fragmentin-3 3 4
  • Tryptase II 2 3
  • Granzyme-3 3 4
  • NK-Tryp-2 3 4
  • TRYP2 3 4
  • EC 63
  • EC 3.4.21.- 4
  • Granzyme 3 3
  • EC 3.4.21 63

External Ids for GZMK Gene

Previous GeneCards Identifiers for GZMK Gene

  • GC05P054483
  • GC05P055748
  • GC05P054290
  • GC05P054335
  • GC05P054355
  • GC05P054320
  • GC05P051293

Summaries for GZMK Gene

Entrez Gene Summary for GZMK Gene

  • This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GZMK Gene

GZMK (Granzyme K) is a Protein Coding gene. Diseases associated with GZMK include Arts Syndrome and Large Granular Lymphocyte Leukemia. Among its related pathways are Granzyme Pathway. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ELANE.

Gene Wiki entry for GZMK Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZMK Gene

Genomics for GZMK Gene

Regulatory Elements for GZMK Gene

Enhancers for GZMK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GZMK on UCSC Golden Path with GeneCards custom track

Genomic Location for GZMK Gene

55,024,253 bp from pter
55,034,570 bp from pter
10,318 bases
Plus strand

Genomic View for GZMK Gene

Genes around GZMK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GZMK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GZMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZMK Gene

Proteins for GZMK Gene

  • Protein details for GZMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Granzyme K
    Protein Accession:
    Secondary Accessions:
    • B2R563

    Protein attributes for GZMK Gene

    264 amino acids
    Molecular mass:
    28882 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GZMK Gene

neXtProt entry for GZMK Gene

Proteomics data for GZMK Gene at MOPED

Selected DME Specific Peptides for GZMK Gene

Post-translational modifications for GZMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GZMK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GZMK Gene

Suggested Antigen Peptide Sequences for GZMK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Granzyme subfamily.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Granzyme subfamily.
genes like me logo Genes that share domains with GZMK: view

No data available for Gene Families for GZMK Gene

Function for GZMK Gene

Enzyme Numbers (IUBMB) for GZMK Gene

genes like me logo Genes that share phenotypes with GZMK: view

Animal Model Products

miRNA for GZMK Gene

miRTarBase miRNAs that target GZMK

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GZMK Gene

Localization for GZMK Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZMK Gene

Secreted. Cytoplasmic granule.

Subcellular locations from

Jensen Localization Image for GZMK Gene COMPARTMENTS Subcellular localization image for GZMK gene
Compartment Confidence
extracellular 5
chloroplast 2
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for GZMK Gene

Pathways & Interactions for GZMK Gene

SuperPathways for GZMK Gene

Superpath Contained pathways
1 Granzyme Pathway
genes like me logo Genes that share pathways with GZMK: view

Pathways by source for GZMK Gene

1 Qiagen pathway for GZMK Gene

Gene Ontology (GO) - Biological Process for GZMK Gene


No data available for SIGNOR curated interactions for GZMK Gene

Drugs & Compounds for GZMK Gene

(2) Drugs for GZMK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GZMK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GZMK: view

Transcripts for GZMK Gene

mRNA/cDNA for GZMK Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GZMK Gene

Granzyme K (granzyme 3; tryptase II):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GZMK Gene

No ASD Table

Relevant External Links for GZMK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GZMK Gene

mRNA expression in normal human tissues for GZMK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GZMK Gene

This gene is overexpressed in Whole Blood (x17.6) and Spleen (x11.7).

Protein differential expression in normal tissues from HIPED for GZMK Gene

This gene is overexpressed in CD8 Tcells (21.7), Peripheral blood mononuclear cells (18.7), Tlymphocyte (12.4), and NK cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GZMK Gene

SOURCE GeneReport for Unigene cluster for GZMK Gene Hs.277937

mRNA Expression by UniProt/SwissProt for GZMK Gene

Tissue specificity: Expressed in lung, spleen, thymus and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with GZMK: view

Protein tissue co-expression partners for GZMK Gene

- Elite partner

Primer Products

Orthologs for GZMK Gene

This gene was present in the common ancestor of chordates.

Orthologs for GZMK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GZMK 35
  • 81.31 (n)
  • 72.73 (a)
  • 73 (a)
(Canis familiaris)
Mammalia GZMK 35
  • 80.56 (n)
  • 72.35 (a)
  • 71 (a)
(Mus musculus)
Mammalia Gzmk 35
  • 78.29 (n)
  • 73.26 (a)
Gzmk 16
Gzmk 36
  • 72 (a)
(Pan troglodytes)
Mammalia GZMK 35
  • 99.62 (n)
  • 99.24 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Gzmk 35
  • 78.44 (n)
  • 73.41 (a)
(Gallus gallus)
Aves GZMK 36
  • 42 (a)
(Danio rerio)
Actinopterygii gzma 35
  • 52.12 (n)
  • 42.37 (a)
gzma 36
  • 37 (a)
gzmk 36
  • 36 (a)
Species with no ortholog for GZMK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GZMK Gene

Gene Tree for GZMK (if available)
Gene Tree for GZMK (if available)

Paralogs for GZMK Gene

Paralogs for GZMK Gene

genes like me logo Genes that share paralogs with GZMK: view

Variants for GZMK Gene

Sequence variations from dbSNP and Humsavar for GZMK Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3776035 -- 55,026,346(+) AGAAG(C/T)GGATT intron-variant
rs3776036 -- 55,026,410(+) TTTTT(C/G/T)TGTTT intron-variant
rs3776038 -- 55,028,398(+) CACCC(C/G/T)GTCCT intron-variant
rs1396500 -- 55,028,127(+) TAGCC(G/T)AGTAA intron-variant
rs3815763 -- 55,034,175(-) GGGTG(C/G)AATGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GZMK Gene

Variant ID Type Subtype PubMed ID
nsv830301 CNV Gain 17160897

Variation tolerance for GZMK Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GZMK Gene

Disorders for GZMK Gene

MalaCards: The human disease database

(2) MalaCards diseases for GZMK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
arts syndrome
  • lethal ataxia with deafness and optic atrophy
large granular lymphocyte leukemia
  • t-cell large granular lymphocyte leukemia
- elite association - COSMIC cancer census association via MalaCards
Search GZMK in MalaCards View complete list of genes associated with diseases

Relevant External Links for GZMK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GZMK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GZMK Gene

Publications for GZMK Gene

  1. Cloning of cDNA for human granzyme 3. (PMID: 7758581) Przetak M.M. … Schmidt B.F. (FEBS Lett. 1995) 2 3 4 23 67
  2. Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. (PMID: 19059912) Bovenschen N. … Kummer J.A. (J. Biol. Chem. 2009) 3 23
  3. Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis. (PMID: 19201868) Hua G. … Fan Z. (J. Immunol. 2009) 3 23
  4. Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. (PMID: 17008916) Zhao T. … Fan Z. (Cell Death Differ. 2007) 3 23
  5. Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. (PMID: 17308307) Zhao T. … Fan Z. (J. Biol. Chem. 2007) 3 23

Products for GZMK Gene

Sources for GZMK Gene