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Aliases for GZMK Gene

Aliases for GZMK Gene

  • Granzyme K (Granzyme 3; Tryptase II) 2 3
  • Granzyme K (Serine Protease, Granzyme 3; Tryptase II) 2 3
  • NK-Tryptase-2 3 4
  • Fragmentin-3 3 4
  • Granzyme-3 3 4
  • NK-Tryp-2 3 4
  • TRYP2 3 4
  • Tryptase II 3
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • Granzyme 3 3
  • Granzyme K 3
  • EC 3.4.21 63

External Ids for GZMK Gene

Previous GeneCards Identifiers for GZMK Gene

  • GC05P054483
  • GC05P055748
  • GC05P054290
  • GC05P054335
  • GC05P054355
  • GC05P054320
  • GC05P051293

Summaries for GZMK Gene

Entrez Gene Summary for GZMK Gene

  • This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GZMK Gene

GZMK (Granzyme K (Granzyme 3; Tryptase II)) is a Protein Coding gene. Diseases associated with GZMK include arts syndrome and t-cell large granular lymphocyte leukemia. Among its related pathways are Granzyme Pathway. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ELANE.

Gene Wiki entry for GZMK Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZMK Gene

Genomics for GZMK Gene

Regulatory Elements for GZMK Gene

Genomic Location for GZMK Gene

Start:
55,024,253 bp from pter
End:
55,034,570 bp from pter
Size:
10,318 bases
Orientation:
Plus strand

Genomic View for GZMK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GZMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZMK Gene

Proteins for GZMK Gene

  • Protein details for GZMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49863-GRAK_HUMAN
    Recommended name:
    Granzyme K
    Protein Accession:
    P49863
    Secondary Accessions:
    • B2R563

    Protein attributes for GZMK Gene

    Size:
    264 amino acids
    Molecular mass:
    28882 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GZMK Gene

neXtProt entry for GZMK Gene

Proteomics data for GZMK Gene at MOPED

Selected DME Specific Peptides for GZMK Gene

Post-translational modifications for GZMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GZMK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for GZMK Gene

Suggested Antigen Peptide Sequences for GZMK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49863

UniProtKB/Swiss-Prot:

GRAK_HUMAN :
  • P49863
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Granzyme subfamily.
genes like me logo Genes that share domains with GZMK: view

No data available for Gene Families for GZMK Gene

Function for GZMK Gene

Enzyme Numbers (IUBMB) for GZMK Gene

Gene Ontology (GO) - Molecular Function for GZMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 8656064
genes like me logo Genes that share ontologies with GZMK: view

Animal Model Products

miRNA for GZMK Gene

miRTarBase miRNAs that target GZMK

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GZMK

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GZMK Gene

Localization for GZMK Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZMK Gene

Secreted. Cytoplasmic granule.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GZMK Gene COMPARTMENTS Subcellular localization image for GZMK gene
Compartment Confidence
extracellular 5
chloroplast 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GZMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GZMK: view

Pathways for GZMK Gene

SuperPathways for GZMK Gene

Superpath Contained pathways
1 Granzyme Pathway
genes like me logo Genes that share pathways with GZMK: view

Pathways by source for GZMK Gene

1 Qiagen pathway for GZMK Gene

Gene Ontology (GO) - Biological Process for GZMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with GZMK: view

Compounds for GZMK Gene

(3) Novoseek inferred chemical compound relationships for GZMK Gene

Compound -log(P) Hits PubMed IDs
serine 65.1 8
arginine 17.5 1
oxygen 0 2
genes like me logo Genes that share compounds with GZMK: view

Transcripts for GZMK Gene

mRNA/cDNA for GZMK Gene

(24) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GZMK Gene

Granzyme K (granzyme 3; tryptase II):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GZMK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GZMK Gene

No ASD Table

Relevant External Links for GZMK Gene

GeneLoc Exon Structure for
GZMK
ECgene alternative splicing isoforms for
GZMK

Expression for GZMK Gene

mRNA expression in normal human tissues for GZMK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GZMK Gene

This gene is overexpressed in Whole Blood (17.6) and Spleen (11.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GZMK Gene

SOURCE GeneReport for Unigene cluster for GZMK Gene Hs.277937

mRNA Expression by UniProt/SwissProt for GZMK Gene

P49863-GRAK_HUMAN
Tissue specificity: Expressed in lung, spleen, thymus and peripheral blood leukocytes
genes like me logo Genes that share expressions with GZMK: view

In Situ Assay Products

Orthologs for GZMK Gene

This gene was present in the common ancestor of chordates.

Orthologs for GZMK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GZMK 35
  • 99.62 (n)
  • 99.24 (a)
GZMK 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GZMK 35
  • 81.31 (n)
  • 72.73 (a)
GZMK 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GZMK 35
  • 80.56 (n)
  • 72.35 (a)
GZMK 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gzmk 35
  • 78.29 (n)
  • 73.26 (a)
Gzmk 16
Gzmk 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gzmk 35
  • 78.44 (n)
  • 73.41 (a)
chicken
(Gallus gallus)
Aves GZMK 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gzma 35
  • 52.12 (n)
  • 42.37 (a)
gzma 36
  • 37 (a)
OneToMany
gzmk 36
  • 36 (a)
OneToMany
Species with no ortholog for GZMK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GZMK Gene

ENSEMBL:
Gene Tree for GZMK (if available)
TreeFam:
Gene Tree for GZMK (if available)

Paralogs for GZMK Gene

Paralogs for GZMK Gene

genes like me logo Genes that share paralogs with GZMK: view

Variants for GZMK Gene

Sequence variations from dbSNP and Humsavar for GZMK Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1396500 -- 55,028,127(+) TAGCC(G/T)AGTAA intron-variant
rs1848502 -- 55,026,648(+) GTTTG(C/G)CCCAA intron-variant
rs1858083 -- 55,029,817(-) GCCAC(C/T)TGGGA intron-variant
rs2112938 -- 55,032,127(-) ataag(A/C)caccg intron-variant
rs3776035 -- 55,026,346(+) AGAAG(C/T)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GZMK Gene

Variant ID Type Subtype PubMed ID
nsv830301 CNV Gain 17160897

Relevant External Links for GZMK Gene

HapMap Linkage Disequilibrium report
GZMK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GZMK Gene

Disorders for GZMK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for GZMK Gene including...

Search for GZMK Gene in MalaCards »

(1) University of Copenhagen DISEASES for GZMK Gene

(2) Novoseek inferred disease relationships for GZMK Gene

Disease -log(P) Hits PubMed IDs
melanoma 13.5 1
tumors 0 1
genes like me logo Genes that share disorders with GZMK: view

No data available for UniProtKB/Swiss-Prot for GZMK Gene

Publications for GZMK Gene

  1. Cloning of cDNA for human granzyme 3. (PMID: 7758581) Przetak M.M. … Schmidt B.F. (FEBS Lett. 1995) 2 3 4 23
  2. Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. (PMID: 8656064) Sayers T.J. … Smyth M.J. (J. Leukoc. Biol. 1996) 3 4 23
  3. The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. (PMID: 12384499) Hink-Schauer C. … Jenne D.E. (J. Biol. Chem. 2002) 3 4 23
  4. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. (PMID: 1460416) Shi L. … Greenberg A.H. (J. Exp. Med. 1992) 3 4 23
  5. Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. (PMID: 17008916) Zhao T. … Fan Z. (Cell Death Differ. 2007) 3 23

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Sources for GZMK Gene

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