Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GZMK Gene

protein-coding   GIFtS: 52
GCID: GC05P054320

Granzyme K (Granzyme 3; Tryptase II)

(Previous names: granzyme K (serine protease, granzyme 3; tryptase II))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Granzyme K (Granzyme 3; Tryptase II)1 2     granzyme-32
Granzyme K (Serine Protease, Granzyme 3; Tryptase II)1 2     Tryptase II2
NK-Tryp-22 3     EC 3.4.21.-3
NK-tryptase-22 3     Fragmentin-33
TRYP22 3     Granzyme-33
fragmentin-32     EC 3.4.218
Granzyme 32     EC 3.4.21.48
Granzyme K2     

External Ids:    HGNC: 47111   Entrez Gene: 30032   Ensembl: ENSG000001130887   OMIM: 6007845   UniProtKB: P498633   

Export aliases for GZMK gene to outside databases

Previous GC identifers: GC05P054483 GC05P055748 GC05P054290 GC05P054335 GC05P054355 GC05P051293


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GZMK Gene:
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic
lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to
recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing
on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular
pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GZMK Gene: 
GZMK (granzyme K (granzyme 3; tryptase II)) is a protein-coding gene. Diseases associated with GZMK include epicondylitis, and arts syndrome, and among its related super-pathways are Granzyme-B Pathway. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is GZMH.

Gene Wiki entry for GZMK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GZMK gene promoter:
         Max1   Elk-1   Nkx2-5   NF-kappaB   SRY   POU2F1   POU2F1a   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGZMK promoter sequence
   Search SABiosciences Chromatin IP Primers for GZMK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GZMK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

GZMK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GZMK gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P054320:  view genomic region     (about GC identifiers)

Start:
54,320,081 bp from pter      End:
54,330,398 bp from pter
Size:
10,318 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRAK_HUMAN, P49863 (See protein sequence)
Recommended Name: Granzyme K precursor  
Size: 264 amino acids; 28882 Da
Subcellular location: Secreted. Cytoplasmic granule
2 PDB 3D structures from and Proteopedia for GZMK:
1MZA (3D)        1MZD (3D)    
Secondary accessions: B2R563

Explore the universe of human proteins at neXtProt for GZMK: NX_P49863

Explore proteomics data for GZMK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49863

  • 4/6 DME Specific Peptides for GZMK (P49863) (see all 6)
     GDSGGPL  CKGDSGG  SGGPLIC  VLTAAHC 

    GZMK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GZMK Protein Expression
    REFSEQ proteins: NP_002095.1  
    ENSEMBL proteins: 
     ENSP00000231009  

    Human Recombinant Protein Products for GZMK: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for GZMK
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GZMK
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GZMK
    GenScript Custom Purified and Recombinant Proteins Services for GZMK
    Novus Biologicals GZMK Proteins
    Novus Biologicals GZMK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GZMK 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    GZMK for ontologies           About GeneDecksing



    GZMK Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GZMK
    GenScript Custom Superior Antibodies Services for GZMK
    Novus Biologicals GZMK Antibodies
    Abcam antibodies for GZMK
    Cloud-Clone Corp. Antibodies for GZMK 
    ThermoFisher Antibody for GZMK
    LSBio Antibodies in human, mouse, rat for GZMK 

    Assay Products for GZMK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GZMK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GZMK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GZMK 
    Cloud-Clone Corp. CLIAs for GZMK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P49863

    ProtoNet protein and cluster: P49863

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: GRAK_HUMAN, P49863
    Similarity: Belongs to the peptidase S1 family. Granzyme subfamily
    Similarity: Contains 1 peptidase S1 domain


    GZMK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS8656064
         
    GZMK for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GZMK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GZMK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GZMK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GZMK 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GZMK
    1 QIAGEN miScript miRNA Assays for microRNA that regulate GZMK:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidGZMK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GZMK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GZMK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GZMK
    Sirion Biotech Customized adenovirus for overexpression of GZMK

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GZMK (see all 7)
    OriGene ORF clones in mouse, rat for GZMK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GZMK (NM_002104)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GZMK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GZMK
    Sirion Biotech Customized lentivirus for stable overexpression of GZMK 
                         Customized lentivirus expression plasmids for stable overexpression of GZMK 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GZMK
    Search LifeMap BioReagents cell lines for GZMK
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GZMK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Granzyme Pathway
    Granzyme Pathway0.42

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GZMK
        Granzyme Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GZMK

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/7 Interacting proteins for GZMK (P498633 ENSP000002310094) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000258947Q135093I2D: score=1 
    TUBB3Q135093I2D: score=1 
    HNRNPKP619783I2D: score=1 
    SETQ011053I2D: score=1 
    SSBP054553I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    GZMK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GZMK for compounds           About GeneDecksing

    EMD Millipore small molecules for GZMK:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GZMK (GRAK)

    3 Novoseek inferred chemical compound relationships for GZMK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 65.1 9 12384499 (1), 16166056 (1), 8039831 (1), 9569606 (1) (see all 8)
    arginine 17.5 1 1460416 (1)
    oxygen 0 12 18179823 (2)

    Search CenterWatch for drugs/clinical trials and news about GZMK / GRAK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GZMK gene: 
    NM_002104.2  

    Unigene Cluster for GZMK:

    Granzyme K (granzyme 3; tryptase II)
    Hs.277937  [show with all ESTs]
    Unigene Representative Sequence: BM918927
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231009(uc003jpl.1) ENST00000512089
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GZMK
    1 QIAGEN miScript miRNA Assays for microRNA that regulate GZMK:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidGZMK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GZMK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GZMK
    Clone
    Products:
         
    OriGene clones in human, mouse for GZMK (see all 7)
    OriGene ORF clones in mouse, rat for GZMK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GZMK (NM_002104)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GZMK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GZMK
    Sirion Biotech Customized lentivirus for stable overexpression of GZMK 
                         Customized lentivirus expression plasmids for stable overexpression of GZMK 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GZMK
    OriGene qSTAR qPCR primer pairs in human, mouse for GZMK
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GZMK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GZMK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GZMK

    Additional mRNA sequence: 

    AK312074.1 BC035802.1 U26174.1 U35237.1 

    1 DOTS entry:

    DT.310659 

    24 AceView cDNA sequences:

    BC035802 U35237 AW183169 AA743283 NM_002104 U26174 CB987798 BM918927 
    CD702487 BI908502 BX091409 AU184897 AA947915 BI837702 CD687238 AA699799 
    AI445141 AA970854 AA005382 CB958972 CD705456 CD702028 AA935709 AA004281 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GZMK expression in normal human tissues (normalized intensities)      GZMK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GZMK Expression
    About this image


    GZMK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T-Cytotoxic Cells Thymus
             Peripheral blood Pan-T Cells   
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus

    See GZMK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GZMK

    SOURCE GeneReport for Unigene cluster: Hs.277937

    UniProtKB/Swiss-Prot: GRAK_HUMAN, P49863
    Tissue specificity: Expressed in lung, spleen, thymus and peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for GZMK
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GZMK
    OriGene qSTAR qPCR primer pairs in human, mouse for GZMK
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GZMK
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GZMK
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GZMK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GZMK gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gzmk1 , 5 granzyme K1, 5 78.29(n)1
    73.26(a)1
      13 (63.93 cM)5
    149451  NM_008196.11  NP_032222.11 
     1131716085 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7950701 granzyme K-like 51.48(n)
    41.35(a)
      795070  XM_001335130.1  XP_001335166.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG167496
    CG129516
    (see all 3)
    --
    26(a)
    26(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3R(5156607-5157617)
    3R(5154998-5156047)


    ENSEMBL Gene Tree for GZMK (if available)
    TreeFam Gene Tree for GZMK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GZMK gene
    GZMH2  PRTN32  PRSS572  CTSG2  CFD2  ELANE2  CMA12  AZU12  
    GZMM2  GZMA2  GZMB2  
    18/97 SIMAP similar genes for GZMK using alignment to 1 protein entry:     GRAK_HUMAN(see all similar genes):
    GZMA    CFD    DF    GZMH    TMPRSS15    KLK9
    CELA1    KLK11    KLK14    KLK8    PLAU    CTRL
    CTSG    GZMM    KLK4    PRSS2    TMPRSS11F    TRY8

    GZMK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/278 SNPs in GZMK are shown (see all 278)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339346741,2
    C--54318150(+) CCGCC-/CA/CACACACACACACACA/C
    ACACACACACACACACACACACA
    ACACA
    2 -- us2k1 cds10--------
    rs1919077561,2
    --54318268(+) ACTGGA/GATGTA 1 -- us2k10--------
    rs1144893281,2
    C,F--54318287(+) CTGACG/ACCATC 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1512846371,2
    --54318291(+) CGCCAC/TCCTGT 1 -- us2k10--------
    rs1841562431,2
    --54318644(+) GTCTAA/GGTCAT 1 -- us2k10--------
    rs1405030421,2
    --54318809(+) ATTAAG/TTTATA 1 -- us2k10--------
    rs355173061,2
    C--54318836(+) TATAGT/GATTAT 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs64502811,2
    C,F,A--54318844(+) TATTTA/TTTATT 1 -- us2k1 tfbs39Minor allele frequency- T:0.44NA WA CSA EA 369
    rs1859310691,2
    --54318903(+) TCTGCC/TGAGCA 1 -- us2k10--------
    rs731306671,2
    C,F--54319039(+) CTGATG/ACGTGA 1 -- us2k12Minor allele frequency- A:0.09WA 120

    HapMap Linkage Disequilibrium report for GZMK (54320081 - 54330398 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GZMK:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830301CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GZMK
    DNA2.0 Custom Variant and Variant Library Synthesis for GZMK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600784    OMIM disorders: --

    12 diseases for GZMK:    About MalaCards
    epicondylitis    arts syndrome    t-cell large granular lymphocyte leukemia    pityriasis rosea
    large granular lymphocyte leukemia    allergic asthma    acute lymphoblastic leukemia    lymphoblastic leukemia
    asthma    multiple sclerosis    melanoma    leukemia

    1 disease from the University of Copenhagen DISEASES database for GZMK:
    Arts syndrome

    GZMK for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for GZMK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 13.5 1 16596996 (1)
    tumors 0 1 19201868 (1)


    Export disorders for GZMK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GZMK gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with GZMK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of cDNA for human granzyme 3. (PubMed id 7758581)1, 2, 3, 9 Przetak M.M.... Schmidt B.F. (1995)
    2. The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. (PubMed id 12384499)1, 2, 9 Hink-Schauer C.... Jenne D.E. (2002)
    3. Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. (PubMed id 8656064)1, 2, 9 Sayers T.J.... Smyth M.J. (1996)
    4. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. (PubMed id 1460416)1, 2, 9 Shi L.... Greenberg A.H. (1992)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization of three serine esterases isolated from human IL-2 activated killer cells. (PubMed id 3262682)1, 2 Hameed A.... Podack E.R. (1988)
    7. Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis. (PubMed id 19201868)1, 9 Hua G....Fan Z. (2009)
    8. Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. (PubMed id 17308307)1, 9 Zhao T....Fan Z. (2007)
    9. Altered levels and molecular forms of granzyme k in plasma from septic patients. (PubMed id 17438453)1, 9 Rucevic M....Lim Y.P. (2007)
    10. Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. (PubMed id 19059912)1, 9 Bovenschen N....Kummer J.A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3003 HGNC: 4711 AceView: GZMK Ensembl:ENSG00000113088 euGenes: HUgn3003
    ECgene: GZMK H-InvDB: GZMK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GZMK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GZMK gene:
    Search GeneIP for patents involving GZMK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for GZMK
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GZMK  
     OriGene qPCR primer pairs and template standards for GZMK   OriGene Protein Over-expression Lysate for GZMK  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GZMK  
     OriGene qSTAR qPCR primer pairs in human, mouse for GZMK   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GZMK   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GZMK   OriGene Custom Protein Services for GZMK  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GZMK
     QIAGEN SeqTarget long-range PCR primers for resequencing GZMK
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GZMK
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GZMK
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GZMK
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GZMK
     GenScript Custom Purified and Recombinant Proteins Services for GZMK GenScript cDNA clones with any tag delivered in your preferred vector for GZMK
     GenScript Custom Assay Services for GZMK GenScript Custom Superior Antibodies Services for GZMK
     GenScript Custom overexpressing Cell Line Services for GZMK CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GZMK promoter
     Search Chromatin IP Primers for GZMK
     RT2 qPCR Primer Assay in human, mouse, rat GZMK
     GNC Network for GZMK
     SABiosciences PCR Arrays including human, mouse, rat GZMK
     Search Tocris compounds for GZMK (GRAK)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for GZMK
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GZMK antibodies
     GZMK proteins
     GZMK lysates
     Antibodies for GZMK
     See all of Abcam's Antibodies, Kits and Proteins for GZMK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GZMK
     Antibodies for GZMK
     ELISAs for GZMK
     CLIAs for GZMK
     Search LifeMap BioReagents cell lines for GZMK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMK
     SwitchGear 3'UTR luciferase reporter plasmids for GZMK
     SwitchGear Promoter luciferase reporter plasmids for GZMK
     ThermoFisher Antibody for GZMK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GZMK
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GZMK
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GZMK
    Customized:
     lentivirus for stable overexpression of GZMK
     lentivirus expression plasmids for stable overexpression of GZMK
     adenovirus for overexpression of GZMK
     LSBio Antibodies in human, mouse, rat for GZMK
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GZMK gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4