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Aliases for GZMH Gene

Aliases for GZMH Gene

  • Granzyme H 2 3 5
  • Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) 2 3
  • Cytotoxic T-Lymphocyte Proteinase 3 4
  • Cathepsin G-Like 2 2 4
  • CTSGL2 3 4
  • CCP-X 3 4
  • CSP-C 3 4
  • Cytotoxic T-Lymphocyte-Associated Serine Esterase 1 3
  • Cathepsin G-Like 2, Protein H-CCPX 3
  • Cytotoxin Serine Protease-C 3
  • Cytotoxic Serine Protease C 4
  • Protein H-CCPX 2
  • EC 3.4.21.79 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • CTLA1 3
  • CGL-2 3
  • CGL2 4

External Ids for GZMH Gene

Previous HGNC Symbols for GZMH Gene

  • CTSGL2

Previous GeneCards Identifiers for GZMH Gene

  • GC14U990026
  • GC14M023065
  • GC14M024145
  • GC14M025075
  • GC14M005190

Summaries for GZMH Gene

Entrez Gene Summary for GZMH Gene

  • This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]

GeneCards Summary for GZMH Gene

GZMH (Granzyme H) is a Protein Coding gene. Among its related pathways are Peptide hormone metabolism and IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is ELANE.

UniProtKB/Swiss-Prot for GZMH Gene

  • Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3 and P4 sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.

Gene Wiki entry for GZMH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZMH Gene

Genomics for GZMH Gene

Regulatory Elements for GZMH Gene

Enhancers for GZMH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GZMH on UCSC Golden Path with GeneCards custom track

Genomic Location for GZMH Gene

Chromosome:
14
Start:
24,606,480 bp from pter
End:
24,609,774 bp from pter
Size:
3,295 bases
Orientation:
Minus strand

Genomic View for GZMH Gene

Genes around GZMH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GZMH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GZMH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZMH Gene

Proteins for GZMH Gene

  • Protein details for GZMH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20718-GRAH_HUMAN
    Recommended name:
    Granzyme H
    Protein Accession:
    P20718
    Secondary Accessions:
    • G3V2C5
    • Q6XGZ0
    • Q6XGZ1

    Protein attributes for GZMH Gene

    Size:
    246 amino acids
    Molecular mass:
    27315 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GZMH Gene

    Alternative splice isoforms for GZMH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GZMH Gene

Proteomics data for GZMH Gene at MOPED

Selected DME Specific Peptides for GZMH Gene

Post-translational modifications for GZMH Gene

  • Glycosylation at Asn 71, Asn 104, and Asn 179
  • Modification sites at PhosphoSitePlus

Other Protein References for GZMH Gene

Antibody Products

Domains & Families for GZMH Gene

Suggested Antigen Peptide Sequences for GZMH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20718

UniProtKB/Swiss-Prot:

GRAH_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Granzyme subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Granzyme subfamily.
genes like me logo Genes that share domains with GZMH: view

No data available for Gene Families for GZMH Gene

Function for GZMH Gene

Molecular function for GZMH Gene

GENATLAS Biochemistry:
cytotoxic T-lymphocyte-associated granule serine protease 2,low expression in LAK and NK cells,(cathepsin G-like 2),(see SPAS@)
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINB1.
UniProtKB/Swiss-Prot Function:
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3 and P4 sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.

Enzyme Numbers (IUBMB) for GZMH Gene

genes like me logo Genes that share phenotypes with GZMH: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GZMH

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GZMH Gene

Localization for GZMH Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZMH Gene

Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GZMH Gene COMPARTMENTS Subcellular localization image for GZMH gene
Compartment Confidence
extracellular 3
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for GZMH Gene

Pathways & Interactions for GZMH Gene

genes like me logo Genes that share pathways with GZMH: view

Interacting Proteins for GZMH Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000216338%0d%0a9606.ENSP00000260956%0d%0a9606.ENSP00000164139%0d%0a
Selected Interacting proteins: P20718-GRAH_HUMAN ENSP00000216338 for GZMH Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for GZMH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016485 protein processing IBA --
GO:0019835 cytolysis IEA --
genes like me logo Genes that share ontologies with GZMH: view

No data available for SIGNOR curated interactions for GZMH Gene

Drugs & Compounds for GZMH Gene

(1) Drugs for GZMH Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GZMH: view

Transcripts for GZMH Gene

Unigene Clusters for GZMH Gene

Granzyme H (cathepsin G-like 2, protein h-CCPX):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GZMH Gene

No ASD Table

Relevant External Links for GZMH Gene

GeneLoc Exon Structure for
GZMH
ECgene alternative splicing isoforms for
GZMH

Expression for GZMH Gene

mRNA expression in normal human tissues for GZMH Gene

mRNA differential expression in normal tissues according to GTEx for GZMH Gene

This gene is overexpressed in Whole Blood (x40.9).

Protein differential expression in normal tissues from HIPED for GZMH Gene

This gene is overexpressed in NK cells (30.8), Tlymphocyte (15.4), and Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GZMH Gene



SOURCE GeneReport for Unigene cluster for GZMH Gene Hs.348264

mRNA Expression by UniProt/SwissProt for GZMH Gene

P20718-GRAH_HUMAN
Tissue specificity: Constituvely expressed in NK cells.
genes like me logo Genes that share expression patterns with GZMH: view

Protein tissue co-expression partners for GZMH Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GZMH Gene

Orthologs for GZMH Gene

This gene was present in the common ancestor of mammals.

Orthologs for GZMH Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gzmg 35
  • 68.84 (n)
  • 59.57 (a)
Gzmg 16
Gzmd 36
  • 56 (a)
OneToMany
Gzme 36
  • 57 (a)
OneToMany
Gzmf 36
  • 57 (a)
OneToMany
Gzmg 36
  • 58 (a)
OneToMany
Gzmn 36
  • 57 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GZMH 35
  • 98.1 (n)
  • 94.72 (a)
GZMH 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gzmf 35
  • 69.86 (n)
  • 61.3 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
Species with no ortholog for GZMH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GZMH Gene

ENSEMBL:
Gene Tree for GZMH (if available)
TreeFam:
Gene Tree for GZMH (if available)

Paralogs for GZMH Gene

Paralogs for GZMH Gene

genes like me logo Genes that share paralogs with GZMH: view

Variants for GZMH Gene

Sequence variations from dbSNP and Humsavar for GZMH Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs20545 - 24,607,700(-) GGAGC(A/C/G)GACCC reference, missense
rs7140465 -- 24,606,325(+) GATTG(A/G)GAAAT downstream-variant-500B
rs7144488 -- 24,606,054(+) CCCAT(C/T)GGAGG downstream-variant-500B
rs8010409 -- 24,611,083(+) CACCG(A/G)AGATC upstream-variant-2KB
rs1957526 -- 24,609,708(+) AGTAA(A/C)CTCAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GZMH Gene

Variant ID Type Subtype PubMed ID
nsv510631 CNV Loss 20534489
nsv901502 CNV Loss 21882294
esv2748495 CNV Deletion 23290073

Variation tolerance for GZMH Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GZMH Gene

Disorders for GZMH Gene

Relevant External Links for GZMH

Genetic Association Database (GAD)
GZMH
Human Genome Epidemiology (HuGE) Navigator
GZMH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GZMH

No disorders were found for GZMH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GZMH Gene

Publications for GZMH Gene

  1. Structure and evolutionary origin of the human granzyme H gene. (PMID: 2049336) Haddad P. … Sasportes M. (Int. Immunol. 1991) 2 3 4 23 67
  2. Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. (PMID: 17765974) Hou Q. … Fan Z. (Mol. Immunol. 2008) 3 23
  3. To study the significance of apoptotic enzyme granzyme H in breast cancer patients. (PMID: 19024195) Razvi N.Z. … Nagra S.A. (J Ayub Med Coll Abbottabad 2008) 3 23
  4. Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition. (PMID: 17363894) Andrade F. … Young C.S. (EMBO J. 2007) 3 23
  5. Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program. (PMID: 17409270) Fellows E. … Kurschus F.C. (Blood 2007) 3 23

Products for GZMH Gene

Sources for GZMH Gene

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