Aliases for GZMH Gene
External Ids for GZMH Gene
Previous HGNC Symbols for GZMH Gene
Previous GeneCards Identifiers for GZMH Gene
This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]
GeneCards Summary for GZMH Gene
GZMH (Granzyme H) is a Protein Coding gene. Among its related pathways are Peptide hormone metabolism and IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is ELANE.
UniProtKB/Swiss-Prot for GZMH Gene
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3 and P4 sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.