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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GZMH Gene

protein-coding   GIFtS: 63
GCID: GC14M025075

Granzyme H (Cathepsin G-Like 2, Protein H-CCPX)


(Previous symbol: CTSGL2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Granzyme H (Cathepsin G-Like 2, Protein H-CCPX)1 2     Cytotoxin Serine Protease-C2
CTSGL21 2 3 5     Granzyme H2
Cytotoxic T-Lymphocyte Proteinase2 3     CGL23
CCP-X2 3     EC 3.4.21.-3
CSP-C2 3     Cathepsin G-Like 23
CGL-22     Cytotoxic Serine Protease C3
CTLA12     EC 3.4.218
Cytotoxic T-Lymphocyte-Associated Serine Esterase 12     EC 3.4.21.798

External Ids:    HGNC: 47101   Entrez Gene: 29992   Ensembl: ENSG000001004507   OMIM: 1168315   UniProtKB: P207183   

Export aliases for GZMH gene to outside databases

Previous GC identifers: GC14U990026 GC14M023065 GC14M024145 GC14M005190


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GZMH Gene:
The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved
serine proteases that eliminate transformed cells and virus-infected cells. This protein, which has
chymotrypsin-like activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic
residues at the P3' and P4' positions. This protein is reported to be constitutively expressed in NK cells and
may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly
cleaving substrates in pathogen-infected cells. Alternative splicing results in multiple transcript variants that
encode different protein isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for GZMH Gene: 
GZMH (granzyme H (cathepsin G-like 2, protein h-CCPX)) is a protein-coding gene. Diseases associated with GZMH include congenital generalized lipodystrophy, and charcot-marie-tooth disease type 2, and among its related super-pathways are Renin-angiotensin system and Granzyme-B Pathway. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRTN3.

UniProtKB/Swiss-Prot: GRAH_HUMAN, P20718
Function: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1
position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated
immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for
viral replication

Gene Wiki entry for GZMH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GZMH gene promoter:
         Elk-1   p53   AML1a   p300   SEF-1 (1)   LCR-F1   TGIF   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGZMH promoter sequence
   Search SABiosciences Chromatin IP Primers for GZMH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GZMH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

GZMH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GZMH gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M025075:  view genomic region     (about GC identifiers)

Start:
25,075,686 bp from pter      End:
25,078,905 bp from pter
Size:
3,220 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRAH_HUMAN, P20718 (See protein sequence)
Recommended Name: Granzyme H precursor  
Size: 246 amino acids; 27315 Da
Subcellular location: Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes
5 PDB 3D structures from and Proteopedia for GZMH:
1LXV (3D)        3TJU (3D)        3TJV (3D)        3TK9 (3D)        4GAW (3D)    
Secondary accessions: G3V2C5 Q6XGZ0 Q6XGZ1
Alternative splicing: 3 isoforms:  P20718-1   P20718-2   P20718-3   

Explore the universe of human proteins at neXtProt for GZMH: NX_P20718

Explore proteomics data for GZMH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20718

  • 4/7 DME Specific Peptides for GZMH (P20718) (see all 7)
     GDSGGPL  VLTAAHC  VTLGAHN  SGGPLVC 

    GZMH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GZMH Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001257709.1  NP_001257710.1  NP_219491.1  

    ENSEMBL proteins: 
     ENSP00000216338   ENSP00000450576   ENSP00000371988  
    Reactome Protein details: P20718
    Human Recombinant Protein Products for GZMH: 
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    Novus Biologicals GZMH Proteins
    Novus Biologicals GZMH Lysates
    Sino Biological Recombinant Protein for GZMH
    Sino Biological Cell Lysate for GZMH 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GZMH 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS--

    GZMH for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P20718

    ProtoNet protein and cluster: P20718

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: GRAH_HUMAN, P20718
    Similarity: Belongs to the peptidase S1 family. Granzyme subfamily
    Similarity: Contains 1 peptidase S1 domain


    GZMH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRAH_HUMAN, P20718
    Function: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1
    position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated
    immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for
    viral replication
    Enzyme regulation: Inhibited by SERPINB1

         Genatlas biochemistry entry for GZMH:
    cytotoxic T-lymphocyte-associated granule serine protease 2,low expression in LAK and NK cells,(cathepsin G-like
    2),(see SPAS@)

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.792 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity NAS2193684
         
    GZMH for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GZMH:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GZMH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GZMH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GZMH 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GZMH About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Renin-angiotensin system
    Metabolism of Angiotensinogen to Angiotensins0.43
    2Granzyme Pathway
    Granzyme Pathway0.42
    3Insulin Processing
    Peptide hormone metabolism0.39
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GZMH
        IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GZMH
        Granzyme Pathway


    4        Reactome Pathways for GZMH
        Metabolism of Angiotensinogen to Angiotensins
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Metabolism of proteins
    Peptide hormone metabolism



    GZMH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GZMH

    5/6 Interacting proteins for GZMH (P207182, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BIDP559573I2D: score=1 
    CASP3P425743I2D: score=1 
    DFFAO002733I2D: score=1 
    KIAA1279Q96EK53I2D: score=1 
    SSBP054553I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS--
    GO:0006915apoptotic process NAS2193684
    GO:0019835cytolysis IEA--

    GZMH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GZMH for compounds           About GeneDecksing

    EMD Millipore small molecules for GZMH:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for GZMH

    Browse Tocris compounds for GZMH (GRAH)

    1 Novoseek inferred chemical compound relationship for GZMH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 55.7 4 17409270 (1), 2007574 (1), 9920846 (1)

    Search CenterWatch for drugs/clinical trials and news about GZMH / GRAH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GZMH gene (3 alternative transcripts): 
    NM_001270780.1  NM_001270781.1  NM_033423.4  

    Unigene Cluster for GZMH:

    Granzyme H (cathepsin G-like 2, protein h-CCPX)
    Hs.348264  [show with all ESTs]
    Unigene Representative Sequence: BC027974
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216338(uc001wpr.1) ENST00000557220(uc010alz.1) ENST00000382548(uc010aly.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GZMH
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GZMH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GZMH
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    OriGene ORF clones in mouse, rat for GZMH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GZMH (NM_033423)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GZMH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GZMH
    Sirion Biotech Customized lentivirus for stable overexpression of GZMH 
                         Customized lentivirus expression plasmids for stable overexpression of GZMH 
    Primer
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    OriGene qPCR primer pairs and template standards for GZMH
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GZMH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GZMH

    Additional mRNA sequence: 

    AY232657.1 AY232658.1 BC027974.1 M36118.1 

    2 DOTS entries:

    DT.100017086  DT.410314 

    24/25 AceView cDNA sequences (see all 25):

    BE550405 BI822150 BE672339 BI837292 AW204493 BM709314 AW196962 BQ054087 
    BC027974 BV198272 AA995670 CD688066 AY232657 AW135778 NM_033423 BQ054303 
    BU732461 BG231545 CD000418 R53038 AY232658 M36118 AA938268 AI347283 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GZMH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTAACCT
    GZMH Expression
    About this image


    See GZMH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GZMH

    SOURCE GeneReport for Unigene cluster: Hs.348264

    UniProtKB/Swiss-Prot: GRAH_HUMAN, P20718
    Tissue specificity: Constituvely expressed in NK cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GZMH gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gzmc1 , 5 granzyme C1, 5 69.26(n)1
    60.66(a)1
      14 (28.19 cM)5
    149401  NM_010371.21  NP_034501.21 
     562314015 
    chicken
    (Gallus gallus)
    Aves CTSG6
    Uncharacterized protein
    41(a)
    possible ortholog
    28(1210143-1212697)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    40(a)
    39(a)
    possible ortholog
    possible ortholog
    GL343717.1(249182-253080)
    GL343717.1(208040-216141)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-165b19.46
    si:ch211-165b19.86
    (see all 5)
    si:ch211-165b19.8
    (see all 5)
    41(a)
    40(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    9(33687862-33689964)
    9(33700477-33702236)


    ENSEMBL Gene Tree for GZMH (if available)
    TreeFam Gene Tree for GZMH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GZMH gene
    PRTN32  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  AZU12  
    GZMM2  GZMA2  GZMB2  
    18/56 SIMAP similar genes for GZMH using alignment to 1 protein entry:     GRAH_HUMAN(see all similar genes):
    GZMB    CTSG    CMA1    GZMA    GZMK    AZU1
    DF    KLK14    KLK4    KLK8    CFD    ELANE
    KLK15    KLK5    KLK7    KLK9    CTRB1    CTRB2

    GZMH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/167 SNPs in GZMH are shown (see all 167)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71444881,2
    C,A--25075260(+) CCCATC/TGGAGG 3 -- ds500112Minor allele frequency- T:0.35NA WA CSA EA 373
    rs799146031,2
    --25075368(+) CTGCTA/GCGTTG 3 -- ds50010--------
    rs1398307221,2
    --25075376(+) TTGTTA/CGGGGA 3 -- ds50010--------
    rs2004162931,2
    --25075434(+) GTTTA-/TTTTTT 3 -- ds50010--------
    rs71404651,2
    C,F--25075531(+) GATTGA/GGAAAT 3 -- ds50015Minor allele frequency- G:0.09NA WA 244
    rs171058941,2
    C,F--25075726(+) TGCAAC/GCCCGA 3 -- ut31 ese34Minor allele frequency- G:0.02NA 260
    rs22363361,2
    C,F,H--25075729(+) AACCCC/TGACTG 3 -- ut31 ese321Minor allele frequency- T:0.06EA NS WA NA CSA 3832
    rs1154939871,2
    C,F--25075810(+) GCTGTA/C/TAGAGG 9 * L syn13WA NA EU 5988
    rs1401399061,2
    C--25075816(+) AGAGGC/TGCTTC 6 H R mis11Minor allele frequency- T:0.00NA 4552
    rs726810161,2
    C,F--25075920(+) GCTACG/ATCCTT 6 /D syn13Minor allele frequency- A:0.01NA EU 5993

    HapMap Linkage Disequilibrium report for GZMH (25075686 - 25078905 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GZMH:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748495CNV Deletion23290073
    nsv901502CNV Loss21882294
    nsv510631CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 116831    OMIM disorders: --

    11 diseases for GZMH:    About MalaCards
    congenital generalized lipodystrophy    charcot-marie-tooth disease type 2    distal hereditary motor neuropathy    lipodystrophy
    charcot-marie-tooth disease    tooth disease    neuropathy    melanoma
    hepatitis b    breast cancer    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for GZMH:
    Lipodystrophy     Distal hereditary motor neuropathy

    GZMH for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for GZMH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 17765974 (1)

    Genetic Association Database (GAD): GZMH
    Human Genome Epidemiology (HuGE) Navigator: GZMH (5 documents)

    Export disorders for GZMH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GZMH gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with GZMH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and evolutionary origin of the human granzyme H gene. (PubMed id 2049336)1, 2, 3, 9 Haddad P....Sasportes M. (1991)
    2. Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C). (PubMed id 2402757)1, 2, 9 Klein J.L.... Dupont B. (1990)
    3. Identification of SERPINB1 as a physiological inhibitor of human granzyme H. (PubMed id 23269243)1, 2 Wang L.... Fan Z. (2013)
    4. Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif. (PubMed id 22156497)1, 2 Wang L....Fan Z. (2012)
    5. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Cloning of a gene that encodes a new member of the human cytotoxic cell protease family. (PubMed id 2193684)1, 2 Meier M.... Bleackley R.C. (1990)
    9. Discordant regulation of granzyme H and granzyme B expression in human lymphocytes. (PubMed id 15069086)1, 9 Sedelies K.A....Trapani J.A. (2004)
    10. Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. (PubMed id 17765974)1, 9 Hou Q....Fan Z. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2999 HGNC: 4710 AceView: GZMH Ensembl:ENSG00000100450 euGenes: HUgn2999
    ECgene: GZMH H-InvDB: GZMH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GZMH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GZMH gene:
    Search GeneIP for patents involving GZMH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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