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GZMH Gene

protein-coding   GIFtS: 62
GCID: GC14M025075

Granzyme H (Cathepsin G-Like 2, Protein H-CCPX)


(Previous symbol: CTSGL2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Granzyme H (Cathepsin G-Like 2, Protein H-CCPX)1 2     Cytotoxin Serine Protease-C2
CTSGL21 2 3 5     Granzyme H2
Cytotoxic T-Lymphocyte Proteinase2 3     CGL23
CCP-X2 3     EC 3.4.21.-3
CSP-C2 3     Cathepsin G-Like 23
CGL-22     Cytotoxic Serine Protease C3
CTLA12     EC 3.4.218
Cytotoxic T-Lymphocyte-Associated Serine Esterase 12     EC 3.4.21.798

External Ids:    HGNC: 47101   Entrez Gene: 29992   Ensembl: ENSG000001004507   OMIM: 1168315   UniProtKB: P207183   

Export aliases for GZMH gene to outside databases

Previous GC identifers: GC14U990026 GC14M023065 GC14M024145 GC14M005190


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GZMH Gene:
The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved
serine proteases that eliminate transformed cells and virus-infected cells. This protein, which has
chymotrypsin-like activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic
residues at the P3' and P4' positions. This protein is reported to be constitutively expressed in NK cells and
may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly
cleaving substrates in pathogen-infected cells. Alternative splicing results in multiple transcript variants that
encode different protein isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for GZMH Gene:
GZMH (granzyme H (cathepsin G-like 2, protein h-CCPX)) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRTN3.

UniProtKB/Swiss-Prot: GRAH_HUMAN, P20718
Function: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1
position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated
immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for
viral replication

Gene Wiki entry for GZMH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the GZMH gene promoter:
         Elk-1   p53   AML1a   p300   SEF-1 (1)   LCR-F1   TGIF   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGZMH promoter sequence
   Search Chromatin IP Primers for GZMH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GZMH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

GZMH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GZMH gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M025075:  view genomic region     (about GC identifiers)

Start:
25,075,686 bp from pter      End:
25,078,905 bp from pter
Size:
3,220 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GRAH_HUMAN, P20718 (See protein sequence)
Recommended Name: Granzyme H precursor  
Size: 246 amino acids; 27315 Da
5 PDB 3D structures from and Proteopedia for GZMH:
1LXV (3D)        3TJU (3D)        3TJV (3D)        3TK9 (3D)        4GAW (3D)    
Secondary accessions: G3V2C5 Q6XGZ0 Q6XGZ1
Alternative splicing: 3 isoforms:  P20718-1   P20718-2   P20718-3   

Explore the universe of human proteins at neXtProt for GZMH: NX_P20718

Explore proteomics data for GZMH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GZMH (P20718) (see all 7)
     GDSGGPL  VLTAAHC  VTLGAHN  SGGPLVC 


    See GZMH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257709.1  NP_001257710.1  NP_219491.1  

    ENSEMBL proteins: 
     ENSP00000216338   ENSP00000450576   ENSP00000371988  
    Reactome Protein details: P20718

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P20718

    ProtoNet protein and cluster: P20718

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: GRAH_HUMAN, P20718
    Similarity: Belongs to the peptidase S1 family. Granzyme subfamily
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with GZMH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRAH_HUMAN, P20718
    Function: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1
    position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated
    immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for
    viral replication
    Enzyme regulation: Inhibited by SERPINB1

         Genatlas biochemistry entry for GZMH:
    cytotoxic T-lymphocyte-associated granule serine protease 2,low expression in LAK and NK cells,(cathepsin G-like
    2),(see SPAS@)

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.792 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity NAS2193684
         
    Find genes that share ontologies with GZMH           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GZMH:
     Decreased number of cells in m 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GZMH

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRAH_HUMAN, P20718: Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0030141secretory granule IBA--

    Find genes that share ontologies with GZMH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GZMH About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Metabolism of Angiotensinogen to Angiotensins0.00
    2IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types0.33
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    5Granzyme Pathway
    Granzyme Pathway


    Find genes that share SuperPaths with GZMH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GZMH
        IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GZMH
        Granzyme Pathway


    2 Reactome Pathways for GZMH
        Metabolism of Angiotensinogen to Angiotensins
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GZMH
    Interactions:

        GeneGlobe Interaction Network for GZMH

    Selected Interacting proteins for GZMH (P207182, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BIDP559573I2D: score=1 
    CASP3P425743I2D: score=1 
    DFFAO002733I2D: score=1 
    KIAA1279Q96EK53I2D: score=1 
    SSBP054553I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IBA--
    GO:0006915apoptotic process NAS2193684
    GO:0019835cytolysis IEA--

    Find genes that share ontologies with GZMH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for GZMH
      Browse compounds at ApexBio 

    Browse Tocris compounds for GZMH (GRAH)

    1 Novoseek inferred chemical compound relationship for GZMH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 55.7 4 17409270 (1), 2007574 (1), 9920846 (1)



    Find genes that share compounds with GZMH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GZMH gene (3 alternative transcripts): 
    NM_001270780.1  NM_001270781.1  NM_033423.4  

    Unigene Cluster for GZMH:

    Granzyme H (cathepsin G-like 2, protein h-CCPX)
    Hs.348264  [show with all ESTs]
    Unigene Representative Sequence: BC027974
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216338(uc001wpr.1) ENST00000557220(uc010alz.1) ENST00000382548(uc010aly.1)

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    Additional mRNA sequence: 

    AY232657.1 AY232658.1 BC027974.1 M36118.1 

    2 DOTS entries:

    DT.100017086  DT.410314 

    Selected AceView cDNA sequences (see all 25):

    BM709314 AW204493 BE550405 BE672339 BI837292 BI822150 AW196962 BC027974 
    BQ054303 NM_033423 BV198272 BU732461 AW135778 AA995670 BG231545 BQ054087 
    AY232657 CD688066 CD000418 R53038 AY232658 AA938268 M36118 AI347283 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GZMH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTAACCT
    GZMH Expression
    About this image

    GZMH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GZMH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348264

    UniProtKB/Swiss-Prot: GRAH_HUMAN, P20718
    Tissue specificity: Constituvely expressed in NK cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for GZMH gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gzmc5
    Gzmg1
    granzyme C5
    granzyme G1
    68.84(n)1
    59.57(a)1
      14 (28.19 cM)5
    149441  NM_010375.21  NP_034505.11 
     562314015 


    ENSEMBL Gene Tree for GZMH (if available)
    TreeFam Gene Tree for GZMH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GZMH gene
    PRTN32  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  AZU12  
    GZMM2  GZMA2  GZMB2  
    Selected SIMAP similar genes for GZMH using alignment to 1 protein entry:     GRAH_HUMAN(see all similar genes):
    GZMB    CTSG    CMA1    GZMA    GZMK    AZU1
    DF    KLK14    KLK4    KLK8    CFD    ELANE
    KLK5    KLK7    KLK15    KLK9    GZMM    CTRB1

    Find genes that share paralogs with GZMH           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GZMH (see all 167)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71444881,2
    C,A--25075260(+) CCCATC/TGGAGG 3 -- ds500112Minor allele frequency- T:0.35NA WA CSA EA 373
    rs799146031,2
    --25075368(+) CTGCTA/GCGTTG 3 -- ds50010--------
    rs1398307221,2
    --25075376(+) TTGTTA/CGGGGA 3 -- ds50010--------
    rs2004162931,2
    --25075434(+) GTTTA-/TTTTTT 3 -- ds50010--------
    rs71404651,2
    C,F--25075531(+) GATTGA/GGAAAT 3 -- ds50015Minor allele frequency- G:0.09NA WA 244
    rs171058941,2
    C,F--25075726(+) TGCAAC/GCCCGA 3 -- ut31 ese34Minor allele frequency- G:0.02NA 260
    rs22363361,2
    C,F,H--25075729(+) AACCCC/TGACTG 3 -- ut31 ese321Minor allele frequency- T:0.06EA NS WA NA CSA 3832
    rs1154939871,2
    C,F--25075810(+) GCTGTA/C/TAGAGG 9 * L syn13WA NA EU 5988
    rs1401399061,2
    C--25075816(+) AGAGGC/TGCTTC 6 H R mis11Minor allele frequency- T:0.00NA 4552
    rs726810161,2
    C,F--25075920(+) GCTACG/ATCCTT 6 /D syn13Minor allele frequency- A:0.01NA EU 5993

    HapMap Linkage Disequilibrium report for GZMH (25075686 - 25078905 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GZMH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748495CNV Deletion23290073
    nsv901502CNV Loss21882294
    nsv510631CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116831    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for GZMH:
    Lipodystrophy     Distal hereditary motor neuropathy

    Find genes that share disorders with GZMH           About GenesLikeMe

    1 Novoseek inferred disease relationship for GZMH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 17765974 (1)

    Genetic Association Database (GAD): GZMH
    Human Genome Epidemiology (HuGE) Navigator: GZMH (5 documents)

    Export disorders for GZMH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GZMH gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with GZMH)
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    1. Structure and evolutionary origin of the human granzyme H gene. (PubMed id 2049336)1, 2, 3, 9 Haddad P....Sasportes M. (Int. Immunol. 1991)
    2. Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C). (PubMed id 2402757)1, 2, 9 Klein J.L.... Dupont B. (Tissue Antigens 1990)
    3. Identification of SERPINB1 as a physiological inhibitor of human granzyme H. (PubMed id 23269243)1, 2 Wang L.... Fan Z. (J. Immunol. 2013)
    4. Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif. (PubMed id 22156497)1, 2 Wang L....Fan Z. (J. Immunol. 2012)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Cloning of a gene that encodes a new member of the human cytotoxic cell protease family. (PubMed id 2193684)1, 2 Meier M.... Bleackley R.C. (Biochemistry 1990)
    9. Discordant regulation of granzyme H and granzyme B expression in human lymphocytes. (PubMed id 15069086)1, 9 Sedelies K.A....Trapani J.A. (J. Biol. Chem. 2004)
    10. Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. (PubMed id 17765974)1, 9 Hou Q....Fan Z. (Mol. Immunol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2999 HGNC: 4710 AceView: GZMH Ensembl:ENSG00000100450 euGenes: HUgn2999
    ECgene: GZMH H-InvDB: GZMH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GZMH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GZMH gene:
    Search GeneIP for patents involving GZMH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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