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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GZMB Gene

protein-coding GIFtS: 67
GCID: GC14M025100

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated...

(Previous symbols: CTLA1, CSPB)

Explore 137 diseases affiliated with
GZMB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1)¹ ²		C11² ³
CSPB¹ ² ³ ⁵		CTLA-1² ³
CTLA1¹ ² ³ ⁵		T-Cell Serine Protease 1-3E² ³
CGL1¹ ² ³		EC 3.4.21.79³ ⁸
CTSGL1¹ ² ³		Cytotoxic Serine Protease B²
HLP¹ ² ³		Fragmentin 2²
SECT¹ ² ³		Fragmentin-2³
CCPI¹ ²		Granzyme B²
CGL-1¹ ²		Fragmentin-2³
CSP-B¹ ²		GRB³
Cathepsin G-Like 1² ³		Granzyme-2³
Cytotoxic T-Lymphocyte Proteinase 2² ³		Lymphocyte Protease³
Human Lymphocyte Protein² ³		EC 3.4.21⁸

External Ids:	HGNC: 4709¹	Entrez Gene: 3002²	Ensembl: ENSG00000100453⁷	OMIM: 123910⁵	UniProtKB: P10144³

Export aliases for GZMB gene to outside databases

Previous GC identifers: GC14M022472 GC14M018887 GC14M023090 GC14M024170 GC14M005214

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GZMB:

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse

specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself'

antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by

this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GRAB_HUMAN, P10144

Function: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems

to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis

execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis

summary for GZMB:

Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of

apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and

effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,

upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector

caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the

executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase

Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors

such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For

example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form

part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by

inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of

many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory

disease.

Gene Wiki entry for GZMB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GZMB gene promoter:
CREB AML1a deltaCREB STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GZMB promoter sequence

Search SABiosciences Chromatin IP Primers for GZMB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GZMB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q11.2

GZMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GZMB gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M025100: view genomic region (about GC identifiers)

Start:	25,100,160 bp from pter	End:	25,103,473 bp from pter
Size:	3,314 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GRAB_HUMAN, P10144 (See protein sequence)

Recommended Name: Granzyme B precursor

Size: 247 amino acids; 27716 Da

Subcellular location: Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer

cells

2 PDB 3D structures from and Proteopedia for GZMB:

1FQ3 (3D)

1IAU (3D)

Secondary accessions: Q8N1D2 Q9UCC1

Explore the universe of human proteins at neXtProt for GZMB: NX_P10144

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10144

4/7 DME Specific Peptides for GZMB (P10144) (see all 7)

GDSGGPL

VLTAAHC

VTLGAHN

SGGPLVC

GZMB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004122.2

ENSEMBL proteins:

ENSP00000387385 ENSP00000216341 ENSP00000432074 ENSP00000450535 ENSP00000435084

ENSP00000434213 ENSP00000371982 ENSP00000371980

Reactome Protein details: P10144
Human Recombinant Protein Products:

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	Uscn Proteins for GZMB

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001772	immunological synapse	TAS	12524539
GO:0005634	nucleus	TAS	11909973
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

GZMB for ontologies About GeneDecksing

GZMB Antibody Products:

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	GenScript Custom Superior Antibodies Services for GZMB
	Novus Biologicals GZMB Antibodies
	Abcam antibodies for GZMB
	Uscn Antibodies for GZMB
	ThermoFisher Antibodies for GZMB

Assay Products for GZMB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISpot Kits & Development Modules for GZMB (Granzyme B)
	GenScript Custom Assay Services for GZMB
	Enzo Life Sciences assays for GZMB
	Uscn ELISAs and CLIAs for GZMB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GZMB for domains About GeneDecksing

4 InterPro domains/families:

IPR001314 Peptidase_S1A

IPR001254 Peptidase_S1

IPR018114 Peptidase_S1_AS

IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P10144

ProtoNet protein and cluster: P10144

2 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: GRAB_HUMAN, P10144

Similarity: Belongs to the peptidase S1 family. Granzyme subfamily

Similarity: Contains 1 peptidase S1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GRAB_HUMAN, P10144

Function: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems

to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis

execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis

Catalytic activity: Preferential cleavage: -Asp- -Xaa- >> -Asn- -Xaa- > -Met- -Xaa-, -Ser- -Xaa-

Enzyme regulation: Inactivated by the serine protease inhibitor diisopropylfluorophosphate

Induction: By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes

Genatlas biochemistry entry for GZMB:

cytotoxic T-lymphocyte-associated granule serine protease 1,also expressed in lymphokine activated killer (LAK) and

natural killer (NK) cells (cathepsin G-like 1) (see SPAS@)

Enzyme Numbers (IUBMB): EC 3.4.21.79¹ ² EC 3.4.21²

miRNA Products:		OriGene 3'-UTR Clone: GZMB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GZMB
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GZMB
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for GZMB

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GZMB
		Search LifeMap BioReagents cell lines for GZMB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMB

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	TAS	12524539
GO:0005515	protein binding	IPI	11911826
GO:0008236	serine-type peptidase activity	TAS	2402757

GZMB for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for GZMB: Gzmb^tm2.1Ley Gzmb^tm2Ley Gzmb^tm1Ley
     6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gzmb):

cellular	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
tumorigenesis

GZMB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Allograft rejection

Allograft rejection	1.00	Autoimmune thyroid disease	0.60
Type I diabetes mellitus	0.67	CTL Mediated Apoptosis	0.38
Graft-versus-host disease	0.63

Granzyme Pathway

Granzyme Pathway

1.00

Granzyme-B Pathway

0.42

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Activation, myristolyation of BID and translocation to mitochondria

Activation, myristolyation of BID and translocation to mitochondria

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 R&D Systems Pathways for GZMB

	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GZMB

	Caspase Cascade
	Granzyme-B Pathway
	RhoGDI Pathway
	Granzyme Pathway
	CTL Mediated Apoptosis

2 Cell Signaling Technology (CST) Pathways for GZMB

	Apoptosis and Autophagy
	Lymphocyte Signaling

4 BioSystems Pathways for GZMB

	Apoptosis
	IL12-mediated signaling events
	Downstream signaling in naive CD8+ T cells
	Caspase cascade in apoptosis

3 Reactome Pathways for GZMB

	Activation, myristolyation of BID and translocation to mitochondria
	Intrinsic Pathway for Apoptosis
	Apoptosis

5 Kegg Pathways (Kegg details for GZMB):

	Natural killer cell mediated cytotoxicity
	Type I diabetes mellitus
	Autoimmune thyroid disease
	Allograft rejection
	Graft-versus-host disease

GZMB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GZMB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for GZMB (P10144^{1, 2, 3} ENSP00000216341⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SRGN	P10124¹^,³, ENSP00000242465⁴	EBI-2505785,EBI-744915 I2D: score=4 STRING: ENSP00000242465
PRF1	P14222¹^,³, ENSP00000316746⁴	EBI-2505785,EBI-724466 I2D: score=3 STRING: ENSP00000316746
ELANE	P08246²^,³, ENSP00000263621⁴	MINT-6803398 I2D: score=1 STRING: ENSP00000263621
CASP3	P42574³, ENSP00000311032⁴	I2D: score=4 STRING: ENSP00000311032
PRKDC	P78527³, ENSP00000313420⁴	I2D: score=3 STRING: ENSP00000313420

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	--	--
GO:0006915	apoptotic process	TAS	--
GO:0006922	cleavage of lamin involved in execution phase of apoptosis	IDA	11331782
GO:0008633	activation of pro-apoptotic gene products	--	--
GO:0019835	cytolysis	IEA	--

GZMB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GZMB for compounds About GeneDecksing

EMD Millipore small molecules for GZMB:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for GZMB

Compounds for GZMB available from Tocris Bioscience About this table

Compound	Action	CAS #
Ac-IEPD-AFC	Fluorogenic granzyme B substrate	--

1 DrugBank Compound for GZMB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-D-Mannose	--	3458-28-4	target	--	17139284 17016423

10/59 Novoseek chemical compound relationships for GZMB gene (see all 59) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	70.6	111	11562487 (2), 12792516 (2), 8626751 (2), 8601703 (2) (see all 80)
concanamycin a	68.1	3	12199864 (1), 11502983 (1)
[alcl]	67.6	8	10396241 (2), 11237071 (1), 18323280 (1), 9028330 (1) (see all 7)
3,4-dichloroisocoumarin	59.7	3	8760815 (1), 9036942 (1)
itcl	58	2	9349234 (2)
mannose 6-phosphate	41.6	14	16280358 (5), 18220730 (1), 15528317 (1), 11081635 (1) (see all 6)
ponasterone a	38.3	1	15367364 (1)
clostripain	35.5	1	14697268 (1)
z-vad-fmk	34.1	1	11050075 (1)
cysteine	25.9	16	8631895 (2), 11278459 (1), 15029525 (1), 8663294 (1) (see all 13)

Search CenterWatch for drugs/clinical trials and news about GZMB / GRAB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GZMB gene:

NM_004131.4

Unigene Cluster for GZMB:

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Hs.1051 [show with all ESTs]

Unigene Representative Sequence: BQ052893

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000415355 ENST00000216341(uc001wps.2 uc010ama.2 uc010amb.2)

ENST00000532263 ENST00000554242 ENST00000530830 ENST00000526004 ENST00000382542

ENST00000382540

miRNA Products:		OriGene 3'-UTR Clone: GZMB Browse OriGene MicroRNA Expression Plasmids
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GZMB

Additional cDNA sequence:

AY232655.1 AY232656.1 AY372494.1 BC030195.1 J03189.1 J04071.1

3 DOTS entries:

DT.410314 DT.97839362 DT.95233859

24/48 AceView cDNA sequences (see all 48):

BE502328 CF528868 AW817157 J04071 BQ012224 AY372494 BU603175 NM_004131

J03189 BM987823 BE502557 BM923149 BI833067 BM917944 AY232654 CB528665

BC030195 BI909392 BM561748 T29763 AW960218 AY232656 BI907734 BX283601

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GZMB About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c
SP1:							-
SP2:
SP3:							-				-

ECgene alternative splicing isoforms for GZMB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GZMB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACGCTACT

About this image
See GZMB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GZMB

SOURCE GeneReport for Unigene cluster: Hs.1051

SABiosciences Expression via Pathway-Focused PCR Arrays including GZMB:

T-Cell Anergy & Immune Tolerance in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GZMB Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GZMB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GZMB gene from 2/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	si:ch211-165b19.4⁶ si:ch211-165b19.8⁶ (see all 7)	si:ch211-165b19.8 (see all 7)	39(a) 39(a) (see all 7)	many ↔ many many ↔ many (see all 7)	9(33687862-33689964) 9(33700477-33702236)
fruit fly (Drosophila melanogaster)	Insecta	CG16749⁶ Try29F⁶ (see all 49)	Trypsin 29F (see all 49)	28(a) 27(a) (see all 49)	possible ortholog possible ortholog (see all 49)	3R(5156607-5157617) 2L(8998537-8999468)

ENSEMBL Gene Tree for GZMB (if available)
TreeFam Gene Tree for GZMB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GZMB gene

PRTN3² GZMH² GZMK² PRSS57² CTSG² CFD² ELANE² CMA1²

AZU1² GZMM² GZMA²

18/65 SIMAP similar genes for GZMB using alignment to 7 protein entries: GRAB_HUMAN (see all proteins) (see all similar genes):

CTSG GZMH CMA1 GZMA KLK4 KLK8

KLK5 GZMK KLK14 CTRB1 ELANE KLK1

AZU1 CFD DF GZMM PRSS1 PRSS57

GZMB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8192922^1,2	C,F,H,	--	5214470(-)	`AGCTCG/ATCCTC`	1	--	ds500¹		9		NS EA NA WA	778
rs79991830^1,2		--	5214808(+)	`TGTCAC/TTGGCC`	1	--	ds500¹		0	--	--	--	--
rs112450811^1,2		--	5215353(+)	`CCCAGG/ATCCTG`	1	--	int¹		1		CSA	2
rs112273185^1,2	F	--	5215479(+)	`ACACAC/ACTGGT`	1	--	int¹		2		CSA	4
rs45562442^1,2	C,F,	--	5216134(+)	`AGGCAT/CAGGAA`	1	--	int¹		3		NA CSA	124
rs45628336^1,2	C,	--	5216152(+)	`AGAGGC/TCAGGA`	1	--	int¹		3		CSA NA EA	242
rs113822535^1,2	C,F,	--	5216177(+)	`GGGCCG/TGCATT`	1	--	int¹		7		NA WA CSA EA	366
rs45442494^1,2	C,F,	--	5216187(+)	`TCCAGG/TGGGAG`	1	--	int¹		5		NA WA EA	246
rs113203204^1,2		--	5216483(+)	`GGAAAG/TTAAGG`	1	--	int¹		1		CSA	1
rs72681027^1,2	C,F,	--	5217256(+)	`CTTTGC/TTTTGT`	1	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for GZMB (25100160 - 25103473 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GZMB: --
Human Gene Mutation Database (HGMD): GZMB

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GZMB for disorders           About GeneDecksing

OMIM gene information: 123910    OMIM disorders: --

20/137 diseases for GZMB (see all 137):    About MalaCards

subcutaneous panniculitis-like t-cell lymphoma toxic epidermal necrolysis pure red-cell aplasia stevens-johnson syndrome

graft versus host disease lymphomatoid papulosis anaplastic large cell lymphoma rasmussen encephalitis

diffuse large b-cell lymphoma hypersensitivity reaction type ii disease acute graft versus host disease cervical intraepithelial neoplasia

alopecia areata infiltrative basal cell carcinoma mycosis fungoides non-small cell lung carcinoma

lichen planus b-cell lymphomas allergic contact dermatitis contact dermatitis

5 diseases from the University of Copenhagen DISEASES database for GZMB:

Lymphoma Influenza Hemophagocytic lymphohistiocytosis Skin disease

Hypersensitivity reaction type II disease

10/93 Novoseek disease relationships for GZMB gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma t-cell	77.2	15	17260002 (3), 9349234 (1), 12688326 (1), 9409191 (1) (see all 11)
lymphoma t-cell peripheral	71.8	1	16160469 (1)
anaplastic large cell lymphoma	67.9	1	18324919 (1)
tumors	57.6	129	11413524 (3), 16497444 (3), 15843372 (2), 16452233 (2) (see all 92)
lymphoma	57.6	51	11413524 (5), 9409191 (3), 14616965 (2), 10368677 (2) (see all 30)
toxic epidermal necrolysis	52.6	2	18409354 (1), 17008937 (1)
lymphomatoid papulosis	50.1	3	10672058 (1), 10233858 (1), 9347791 (1)
stevens-johnson syndrome	50	2	18409354 (1), 17008937 (1)
necrosis	46.9	48	9250156 (2), 17260002 (2), 17258890 (2), 15855326 (1) (see all 42)
lymphoma large cell	45.4	3	10492036 (1), 14712286 (1)

Human Genome Epidemiology (HuGE) Navigator: GZMB (13 documents)

Export disorders for GZMB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GZMB gene, integrated from 9 sources (see all 862):
(articles sorted by number of sources associating them with GZMB)

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Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14. (PubMed id 2323780)^{1, 2, 3} Dahl C.A.... Cairns J.S. (1990)
The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1. (PubMed id 11325591)^{1, 2, 9} Rotonda J.... Becker J.W. (2001)
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue. (PubMed id 11209755)^{1, 2, 9} Estebanez-Perpina E.... Bode W. (2000)
Nucleotide sequence and genomic organization of a human T lymphocyte serine protease gene. (PubMed id 2365998)^{1, 2, 9} Caputo A.... Rowe P.B. (1990)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. (PubMed id 12721789)^{1, 2} Saito S....Nakamura Y. (2003)
Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity. (PubMed id 1985927)^{1, 2} Poe M....Zweerink H.J. (1991)
Structural organization of the hCTLA-1 gene encoding human granzyme B. (PubMed id 2332171)^{1, 2} Haddad P.... Mathieu-Mahul D. (1990)
Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes. (PubMed id 2788607)^{1, 2} Klein J.L.... Trapani J.A. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3002	HGNC: 4709	AceView: GZMB	Ensembl:ENSG00000100453	euGenes: HUgn3002
ECgene: GZMB	Kegg: 3002	H-InvDB: GZMB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GZMB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GZMB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GZMB gene:
Search GeneIP for patents involving GZMB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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GZMB Gene

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated...

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GZMB (Gene Symbol)
Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1)
CSPB
CTLA1
CGL1
CTSGL1
HLP
SECT
CCPI
CGL-1
CSP-B
Cathepsin G-Like 1
Cytotoxic T-Lymphocyte Proteinase 2
Human Lymphocyte Protein
C11
CTLA-1
T-Cell Serine Protease 1-3E
EC 3.4.21.79
Cytotoxic Serine Protease B
Fragmentin 2
Fragmentin-2
Granzyme B
Fragmentin-2
GRB
Granzyme-2
Lymphocyte Protease
EC 3.4.21

Lymphoma Large Cell
Microsatellite Instability
Hepatitis Chronic
Carcinoma Basal Cell
Sclerosis
Lymphoma T-Cell
Colitis Ulcerative
Allergic Reaction
COLON CARCINOMA
Liver diseases
Atherosclerosis
Breast Cancer
Sjogrens Syndrome Primary
anaplastic large cell lymphoma
NSCLC
primary tumor
Rasmussen Encephalitis
Asthma
BILIARY CIRRHOSIS PRIMARY
Mycosis Fungoides
Cancer
Alopecia Areata
Cervical Intraepithelial Neoplasia
Lymphocytosis
Urticaria
Lymphoma
Shock
Bronchoalveolar Lavage Fluid
Colorectal Cancer
Cowpox
Inflammation
Tuberculosis
Hepatitis
Neutropenia
Psoriasis
Hepatitis B
Pulmonary Disease Chronic Obstructive
Sarcoidosis
Rheumatoid Arthritis
prostate cancer
Tumors
Lymphomatoid Papulosis
Celiac Disease
Autoimmunity
Necrosis
Liver Cirrhosis
Asthma allergic
Lichen Planus
virus infection
Lymphoma T-Cell Cutaneous
Gastric Cancer
Stevens-Johnson Syndrome
Leukemia Lymphocytic Large Granular
Autoimmune Diseases
Melanoma
BREAST CARCINOMA
Toxic Epidermal Necrolysis
Dermatitis
Demyelination
atherosclerotic plaque
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Myeloid Leukemia Chronic
Sjogrens Syndrome
HEPATOCELLULAR CARCINOMA
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metastatic melanoma
Acute graft-versus-host disease
Cancer Lung
Influenza
Keratoacanthoma
cytopenia
Lymphoma B-Cell
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SKIN LESION
Autoimmune Response
Atrophy
Anemia Aplastic
Graft-Versus-Host Disease
Myositis
Lymphoma Non-Hodgkins
Polymyositis
Myelodysplastic Syndromes
Lymphoma T-Cell Peripheral
LEUKAEMIA LYMPHOCYTIC
Choriocarcinoma
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GZMB Gene

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated...

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