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Aliases for GZMB Gene

Aliases for GZMB Gene

  • Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1) 2 3
  • T-Cell Serine Protease 1-3E 2 3 4
  • Cathepsin G-Like 1 2 3 4
  • Cytotoxic T-Lymphocyte Proteinase 2 3 4
  • Cytotoxic Serine Protease B 2 3
  • Human Lymphocyte Protein 3 4
  • Fragmentin 2 2 3
  • Fragmentin-2 3 4
  • EC 3.4.21.79 4 63
  • CTLA-1 3 4
  • CTSGL1 3 4
  • CTLA1 3 4
  • CSPB 3 4
  • CGL1 3 4
  • SECT 3 4
  • HLP 3 4
  • C11 3 4
  • Cathepsin G-Like 1) 6
  • Lymphocyte Protease 4
  • Granzyme B 3
  • Granzyme-2 4
  • EC 3.4.21 63
  • CGL-1 3
  • CSP-B 3
  • CCPI 3
  • GRB 4

External Ids for GZMB Gene

Previous Symbols for GZMB Gene

  • CTLA1
  • CSPB

Summaries for GZMB Gene

Entrez Gene Summary for GZMB Gene

  • Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for GZMB Gene

GZMB (Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1)) is a Protein Coding gene. Diseases associated with GZMB include peripheral t-cell lymphoma and subcutaneous panniculitis-like t-cell lymphoma. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ELANE.

UniProtKB/Swiss-Prot for GZMB Gene

  • This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis

Tocris Summary for GZMB Gene

  • Caspases (short for cysteinyl aspartate proteases) are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of many disorders including stroke, Alzheimers disease, myocardial infarction, cancer, and inflammatory disease.

Gene Wiki entry for GZMB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZMB Gene

Genomics for GZMB Gene

Genomic Location for GZMB Gene

Start:
24,630,954 bp from pter
End:
24,634,267 bp from pter
Size:
3,314 bases
Orientation:
Minus strand

Genomic View for GZMB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GZMB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZMB Gene

Regulatory Elements for GZMB Gene

Proteins for GZMB Gene

  • Protein details for GZMB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10144-GRAB_HUMAN
    Recommended name:
    Granzyme B
    Protein Accession:
    P10144
    Secondary Accessions:
    • Q8N1D2
    • Q9UCC1

    Protein attributes for GZMB Gene

    Size:
    247 amino acids
    Molecular mass:
    27716 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GZMB Gene

neXtProt entry for GZMB Gene

Proteomics data for GZMB Gene at MOPED

Selected DME Specific Peptides for GZMB Gene

Post-translational modifications for GZMB Gene

  • Glycosylation at Asn71 and Asn104

Other Protein References for GZMB Gene

Domains for GZMB Gene

Suggested Antigen Peptide Sequences for GZMB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10144

UniProtKB/Swiss-Prot:

GRAB_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • P10144
Family:
  • Belongs to the peptidase S1 family. Granzyme subfamily.:
    • P10144
genes like me logo Genes that share domains with GZMB: view

No data available for Gene Families for GZMB Gene

Function for GZMB Gene

Molecular function for GZMB Gene

GENATLAS Biochemistry: cytotoxic T-lymphocyte-associated granule serine protease 1,also expressed in lymphokine activated killer (LAK) and natural killer (NK) cells (cathepsin G-like 1) (see SPAS@)
UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: -Asp- -Xaa- >> -Asn- -Xaa- > -Met- -Xaa-, -Ser- -Xaa-.
UniProtKB/Swiss-Prot EnzymeRegulation: Inactivated by the serine protease inhibitor diisopropylfluorophosphate.
UniProtKB/Swiss-Prot Function: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis
UniProtKB/Swiss-Prot Induction: By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes

Enzyme Numbers (IUBMB) for GZMB Gene

Gene Ontology (GO) - Molecular Function for GZMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity TAS 12524539
GO:0005515 protein binding IPI 11911826
GO:0008236 serine-type peptidase activity TAS 2402757
genes like me logo Genes that share ontologies with GZMB: view
genes like me logo Genes that share phenotypes with GZMB: view

Animal Models for GZMB Gene

MGI Knock Outs for GZMB:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for GZMB Gene

Localization for GZMB Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZMB Gene

Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GZMB Gene COMPARTMENTS Subcellular localization image for GZMB gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
extracellular 3
lysosome 2
mitochondrion 2
vacuole 2
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for GZMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse TAS 12524539
GO:0005634 nucleus TAS 11909973
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GZMB: view

Pathways for GZMB Gene

genes like me logo Genes that share pathways with GZMB: view

Gene Ontology (GO) - Biological Process for GZMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0006915 apoptotic process TAS 12524539
GO:0006955 immune response IBA --
GO:0007219 Notch signaling pathway TAS --
GO:0008626 granzyme-mediated apoptotic signaling pathway IBA --
genes like me logo Genes that share ontologies with GZMB: view

Compounds for GZMB Gene

(5) Tocris Compounds for GZMB Gene

Compound Action Cas Number
AZ 10417808 Selective non-peptide caspase-3 inhibitor [331645-84-2]
Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3 [15663-27-1]
Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor
Z-DQMD-FMK Caspase-3 inhibitor
Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor [187389-52-2]

(1) Drugbank Compounds for GZMB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target

(59) Novoseek inferred chemical compound relationships for GZMB Gene

Compound -log(P) Hits PubMed IDs
serine 70.6 87
concanamycin a 68.1 2
[alcl] 67.6 8
3,4-dichloroisocoumarin 59.7 2
itcl 58 2
genes like me logo Genes that share compounds with GZMB: view

Transcripts for GZMB Gene

Unigene Clusters for GZMB Gene

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GZMB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -

Relevant External Links for GZMB Gene

GeneLoc Exon Structure for
GZMB
ECgene alternative splicing isoforms for
GZMB

Expression for GZMB Gene

mRNA expression in normal human tissues for GZMB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GZMB Gene

This gene is overexpressed in Whole Blood (42.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GZMB Gene

SOURCE GeneReport for Unigene cluster for GZMB Gene Hs.1051

genes like me logo Genes that share expressions with GZMB: view

No data available for mRNA Expression by UniProt/SwissProt for GZMB Gene

Orthologs for GZMB Gene

This gene was present in the common ancestor of mammals.

Orthologs for GZMB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GZMB 35
  • 98.65 (n)
  • 97.98 (a)
GZMB 36
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GZMB 35
  • 79.64 (n)
  • 72.95 (a)
GZMB 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GZMB 35
  • 76.75 (n)
  • 70.17 (a)
GZMB 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gzmb 16
Gzmb 36
  • 68 (a)
OneToMany
Gzmc 36
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gzmbl2 35
  • 77.25 (n)
  • 70.39 (a)
Species with no ortholog for GZMB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GZMB Gene

ENSEMBL:
Gene Tree for GZMB (if available)
TreeFam:
Gene Tree for GZMB (if available)

Paralogs for GZMB Gene

Paralogs for GZMB Gene

genes like me logo Genes that share paralogs with GZMB: view

Variants for GZMB Gene

Sequence variations from dbSNP and Humsavar for GZMB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs985931 -- 24,636,135(+) GAAAA(A/G)TAATA upstream-variant-2KB
rs1126639 -- 24,632,342(-) TCCAA(C/T)GACAT reference, synonymous-codon
rs2236337 -- 24,631,041(+) TTCAT(C/T)ACAGC utr-variant-3-prime
rs2236338 - 24,631,076(+) TTAGT(A/G)GCGTT missense, reference
rs2273843 -- 24,634,203(+) TTTCC(C/T)CCTTG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GZMB Gene

Variant ID Type Subtype PubMed ID
nsv510631 CNV Loss 20534489
nsv901502 CNV Loss 21882294
esv2748495 CNV Deletion 23290073

Relevant External Links for GZMB Gene

HapMap Linkage Disequilibrium report
GZMB
Human Gene Mutation Database (HGMD)
GZMB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GZMB Gene

Disorders for GZMB Gene

(93) Novoseek inferred disease relationships for GZMB Gene

Disease -log(P) Hits PubMed IDs
lymphoma t-cell 77.2 13
lymphoma t-cell peripheral 71.8 1
anaplastic large cell lymphoma 67.9 1
tumors 57.6 105
lymphoma 57.6 38

Relevant External Links for GZMB

Genetic Association Database (GAD)
GZMB
Human Genome Epidemiology (HuGE) Navigator
GZMB
genes like me logo Genes that share disorders with GZMB: view

No data available for UniProtKB/Swiss-Prot for GZMB Gene

Publications for GZMB Gene

  1. Nucleotide sequence and genomic organization of a human T lymphocyte serine protease gene. (PMID: 2365998) Caputo A. … Rowe P.B. (J. Immunol. 1990) 3 4 23
  2. Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue. (PMID: 11209755) Estebanez-Perpina E. … Bode W. (Biol. Chem. 2000) 3 4 23
  3. The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1. (PMID: 11325591) Rotonda J. … Becker J.W. (Chem. Biol. 2001) 3 4 23
  4. Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients. (PMID: 17198275) Girnita D.M. … Zeevi A. (Transplantation 2006) 3 23 48
  5. Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients. (PMID: 19446661) Gaafar A. … Al-Hussein K. (Exp. Hematol. 2009) 3 23 48

Products for GZMB Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
    • T-Cell Anergy & Immune Tolerance in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GZMB
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GZMB
    • Block miRNA regulation of GZMB using miScript Target Protectors

    Sources for GZMB Gene

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