Aliases for GZMB Gene
- Granzyme B 2 3 5
- T-Cell Serine Protease 1-3E 2 3 4
- Cathepsin G-Like 1 2 3 4
- Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1) 2 3
- Cytotoxic T-Lymphocyte-Associated Serine Esterase 1 2 3
- Cytotoxic T-Lymphocyte Proteinase 2 3 4
- Cytotoxic Serine Protease B 2 3
- Human Lymphocyte Protein 3 4
- Fragmentin 2 2 3
- Fragmentin-2 3 4
- EC 22.214.171.124 4 63
- Granzyme 2 2 3
- CTLA-1 3 4
- CTSGL1 3 4
External Ids for GZMB Gene
Previous HGNC Symbols for GZMB Gene
Previous GeneCards Identifiers for GZMB Gene
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]
GeneCards Summary for GZMB Gene
GZMB (Granzyme B) is a Protein Coding gene. Diseases associated with GZMB include anaplastic large cell lymphoma and hypersensitivity syndrome, carbamazepine-induced. Among its related pathways are Signaling by GPCR and Innate Lymphoid Cell Differentiation Pathways. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ELANE.
UniProtKB/Swiss-Prot for GZMB Gene
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.