Aliases for GZMB Gene
- Granzyme B 2 3 5
- T-Cell Serine Protease 1-3E 2 3 4
- Cathepsin G-Like 1 2 3 4
- Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1) 2 3
- Cytotoxic T-Lymphocyte Proteinase 2 3 4
- Cytotoxic Serine Protease B 2 3
- Human Lymphocyte Protein 3 4
- Fragmentin 2 2 3
- EC 22.214.171.124 4 61
- CTSGL1 3 4
- CTLA1 3 4
- CSPB 3 4
- CGL1 3 4
- SECT 3 4
External Ids for GZMB Gene
Previous HGNC Symbols for GZMB Gene
Previous GeneCards Identifiers for GZMB Gene
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
GeneCards Summary for GZMB Gene
GZMB (Granzyme B) is a Protein Coding gene. Diseases associated with GZMB include Lymphocytic Gastritis and Natural Killer Cell Leukemia. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is GZMH.
UniProtKB/Swiss-Prot for GZMB Gene
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.