Aliases for GZMA Gene
External Ids for GZMA Gene
Previous HGNC Symbols for GZMA Gene
Previous GeneCards Identifiers for GZMA Gene
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for GZMA Gene
GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated Serine Esterase 3)) is a Protein Coding gene. Diseases associated with GZMA include chediak-higashi syndrome. Among its related pathways are Peptide ligand-binding receptors and Apoptosis and Autophagy. GO annotations related to this gene include protein homodimerization activity and serine-type endopeptidase activity. An important paralog of this gene is ELANE.
UniProtKB/Swiss-Prot for GZMA Gene
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after Lys-31 and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after Lys-189, which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.