Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GZMA Gene

Aliases for GZMA Gene

  • Granzyme A 2 3 5
  • CTL Tryptase 2 3 4
  • Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated Serine Esterase 3) 2 3
  • Cytotoxic T-Lymphocyte-Associated Serine Esterase-3 2 3
  • Cytotoxic T-Lymphocyte Proteinase 1 3 4
  • Hanukah Factor Serine Protease) 2 3
  • Fragmentin-1 3 4
  • Granzyme 1 2 3
  • H Factor 3 4
  • CTLA3 3 4
  • HFSP 3 4
  • HF 3 4
  • Granzyme A (Cytotoxic T-Lymphocyte-Associated Serine Esterase-3; Hanukah Factor Serine Protease) 3
  • Hanukkah Factor 4
  • EC 3.4.21.78 4
  • Granzyme-1 4
  • EC 3.4.21 63

External Ids for GZMA Gene

Previous HGNC Symbols for GZMA Gene

  • HFSP
  • CTLA3

Previous GeneCards Identifiers for GZMA Gene

  • GC05P054561
  • GC05P055827
  • GC05P054352
  • GC05P054414
  • GC05P054434
  • GC05P051373
  • GC05P054398

Summaries for GZMA Gene

Entrez Gene Summary for GZMA Gene

  • Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for GZMA Gene

GZMA (Granzyme A) is a Protein Coding gene. Diseases associated with GZMA include chilblain lupus. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Peptide ligand-binding receptors. GO annotations related to this gene include protein homodimerization activity and serine-type peptidase activity. An important paralog of this gene is ELANE.

UniProtKB/Swiss-Prot for GZMA Gene

  • Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after Lys-31 and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after Lys-189, which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.

Gene Wiki entry for GZMA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZMA Gene

Genomics for GZMA Gene

Regulatory Elements for GZMA Gene

Genomic Location for GZMA Gene

Chromosome:
5
Start:
55,102,646 bp from pter
End:
55,110,252 bp from pter
Size:
7,607 bases
Orientation:
Plus strand

Genomic View for GZMA Gene

Genes around GZMA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GZMA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GZMA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZMA Gene

Proteins for GZMA Gene

  • Protein details for GZMA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12544-GRAA_HUMAN
    Recommended name:
    Granzyme A
    Protein Accession:
    P12544
    Secondary Accessions:
    • A4PHN1
    • Q6IB36

    Protein attributes for GZMA Gene

    Size:
    262 amino acids
    Molecular mass:
    28999 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with APEX1.

    Three dimensional structures from OCA and Proteopedia for GZMA Gene

    Alternative splice isoforms for GZMA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GZMA Gene

Proteomics data for GZMA Gene at MOPED

Selected DME Specific Peptides for GZMA Gene

Post-translational modifications for GZMA Gene

  • Glycosylation at Asn 170
  • Modification sites at PhosphoSitePlus

Other Protein References for GZMA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GZMA (GZMA)

Domains & Families for GZMA Gene

Suggested Antigen Peptide Sequences for GZMA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12544

UniProtKB/Swiss-Prot:

GRAA_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Granzyme subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Granzyme subfamily.
genes like me logo Genes that share domains with GZMA: view

No data available for Gene Families for GZMA Gene

Function for GZMA Gene

Molecular function for GZMA Gene

GENATLAS Biochemistry:
cytotoxic T-lymphocyte-associated granule serine protease 3,Hanuka factor,lymphocyte tryptase 1
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg- -Xaa-, -Lys- -Xaa- >> -Phe- -Xaa- in small molecule substrates.
UniProtKB/Swiss-Prot Function:
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after Lys-31 and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after Lys-189, which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
UniProtKB/Swiss-Prot Induction:
Dexamethasone (DEX) induces expression of isoform beta and represses expression of isoform alpha. The alteration in expression is mediated by binding of glucocorticoid receptor to independent promoters adjacent to the alternative first exons of isoform alpha and isoform beta.

Enzyme Numbers (IUBMB) for GZMA Gene

genes like me logo Genes that share phenotypes with GZMA: view

Animal Models for GZMA Gene

MGI Knock Outs for GZMA:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GZMA Gene

Localization for GZMA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZMA Gene

Isoform alpha: Secreted. Cytoplasmic granule.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GZMA Gene COMPARTMENTS Subcellular localization image for GZMA gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytosol 2
lysosome 2
vacuole 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GZMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GZMA: view

Pathways & Interactions for GZMA Gene

genes like me logo Genes that share pathways with GZMA: view

Pathways by source for GZMA Gene

SIGNOR curated interactions for GZMA Gene

Inactivates:

Gene Ontology (GO) - Biological Process for GZMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 12524539
GO:0043065 positive regulation of apoptotic process IDA 12524539
GO:0043392 negative regulation of DNA binding IDA 12524539
GO:0051354 negative regulation of oxidoreductase activity IDA 12524539
GO:0051603 proteolysis involved in cellular protein catabolic process IDA 12524539
genes like me logo Genes that share ontologies with GZMA: view

Drugs & Compounds for GZMA Gene

(7) Drugs for GZMA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for GZMA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GZMA: view

Transcripts for GZMA Gene

mRNA/cDNA for GZMA Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(115) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GZMA Gene

Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GZMA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for GZMA Gene

GeneLoc Exon Structure for
GZMA
ECgene alternative splicing isoforms for
GZMA

Expression for GZMA Gene

mRNA expression in normal human tissues for GZMA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GZMA Gene

This gene is overexpressed in Whole Blood (x28.2) and Spleen (x7.5).

Protein differential expression in normal tissues from HIPED for GZMA Gene

This gene is overexpressed in NK cells (40.0), Tlymphocyte (9.7), and CD8 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GZMA Gene



SOURCE GeneReport for Unigene cluster for GZMA Gene Hs.90708

genes like me logo Genes that share expression patterns with GZMA: view

Protein tissue co-expression partners for GZMA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GZMA Gene

Orthologs for GZMA Gene

This gene was present in the common ancestor of chordates.

Orthologs for GZMA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GZMA 35
  • 82.75 (n)
  • 73.36 (a)
GZMA 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GZMA 35
  • 81.67 (n)
  • 73.46 (a)
GZMA 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gzma 35
  • 77.78 (n)
  • 71.25 (a)
Gzma 16
Gzma 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GZMA 35
  • 99.24 (n)
  • 98.09 (a)
GZMA 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gzma 35
  • 78.84 (n)
  • 72.2 (a)
oppossum
(Monodelphis domestica)
Mammalia GZMA 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GZMA 35
  • 62.15 (n)
  • 55.08 (a)
GZMA 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497188 35
  • 55.12 (n)
  • 45.89 (a)
Species with no ortholog for GZMA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GZMA Gene

ENSEMBL:
Gene Tree for GZMA (if available)
TreeFam:
Gene Tree for GZMA (if available)

Paralogs for GZMA Gene

Paralogs for GZMA Gene

Pseudogenes.org Pseudogenes for GZMA Gene

genes like me logo Genes that share paralogs with GZMA: view

Variants for GZMA Gene

Sequence variations from dbSNP and Humsavar for GZMA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3104233 - 55,108,129(-) TTTCC(A/G)TCAGC reference, missense
rs1051846 -- 55,108,229(+) TGGGG(C/G)AGGAC reference, synonymous-codon
rs2069185 -- 55,102,257(-) AAATT(C/T)TTTCT upstream-variant-2KB
rs2069186 -- 55,102,237(-) CTTGG(A/G)TTATA upstream-variant-2KB
rs2069187 -- 55,102,221(-) ATTAG(C/G/T)AGGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GZMA Gene

Variant ID Type Subtype PubMed ID
nsv830301 CNV Gain 17160897
nsv4833 CNV Loss 18451855
esv2503041 CNV Deletion 19546169
nsv830302 CNV Gain 17160897

Variation tolerance for GZMA Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GZMA Gene

HapMap Linkage Disequilibrium report
GZMA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GZMA Gene

Disorders for GZMA Gene

MalaCards: The human disease database

(1) MalaCards diseases for GZMA Gene - From: DISEASES

Disorder Aliases PubMed IDs
chilblain lupus
  • chilblain lupus 1
- elite association - COSMIC cancer census association via MalaCards
Search GZMA in MalaCards View complete list of genes associated with diseases

Relevant External Links for GZMA

Genetic Association Database (GAD)
GZMA
Human Genome Epidemiology (HuGE) Navigator
GZMA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GZMA
genes like me logo Genes that share disorders with GZMA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GZMA Gene

Publications for GZMA Gene

  1. Characterization of three serine esterases isolated from human IL-2 activated killer cells. (PMID: 3262682) Hameed A. … Podack E.R. (J. Immunol. 1988) 2 3 4 67
  2. Regulatory role of 1, 25-dihydroxyvitamin D3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis. (PMID: 19014932) Vidyarani M. … Narayanan P.R. (Exp. Mol. Pathol. 2009) 3 23
  3. The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1. (PMID: 19506301) Zhu P. … Lieberman J. (Blood 2009) 3 23
  4. Granzyme A is a proinflammatory protease. (PMID: 19875524) Pardo J. … Froelich C.J. (Blood 2009) 3 23
  5. Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. (PMID: 18485875) Martinvalet D. … Lieberman J. (Cell 2008) 3 23

Products for GZMA Gene

Sources for GZMA Gene

Back to Top

Content