Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GZMA Gene

protein-coding   GIFtS: 64
GCID: GC05P054398

Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated...


(Previous symbols: HFSP, CTLA3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated Serine
Esterase 3)1 2
     fragmentin-12
CTLA31 2 3 5     Granzyme A2
HFSP1 2 3 5     EC 3.4.21.783
CTL Tryptase1 2 3     Fragmentin-13
Granzyme A (Cytotoxic T-Lymphocyte-Associated Serine Esterase-3; Hanukah
Factor Serine Protease)1 2
     Granzyme-13
Cytotoxic T-Lymphocyte Proteinase 12 3     Hanukkah Factor3
H Factor2 3     EC 3.4.218
HF2 3     

External Ids:    HGNC: 47081   Entrez Gene: 30012   Ensembl: ENSG000001456497   OMIM: 1400505   UniProtKB: P125443   

Export aliases for GZMA gene to outside databases

Previous GC identifers: GC05P054561 GC05P055827 GC05P054352 GC05P054414 GC05P054434 GC05P051373


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GZMA Gene:
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and
lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface
'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein
described here is a T cell- and natural killer cell-specific serine protease that may function as a common
component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. (provided by
RefSeq, Jul 2008)

GeneCards Summary for GZMA Gene: 
GZMA (granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)) is a protein-coding gene. Diseases associated with GZMA include polymyositis, and cutaneous leishmaniasis, and among its related super-pathways are Granzyme-B Pathway and Class A/1 (Rhodopsin-like receptors). GO annotations related to this gene include protein homodimerization activity and serine-type endopeptidase activity. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: GRAA_HUMAN, P12544
Function: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys
or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis

Gene Wiki entry for GZMA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GZMA gene promoter:
         AML1a   MEF-2   GATA-1   YY1   C/EBPalpha   MEF-2A   FOXJ2 (long isoform)   FOXO4   FOXJ2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGZMA promoter sequence
   Search SABiosciences Chromatin IP Primers for GZMA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GZMA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11-q12   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11-q12

GZMA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GZMA gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P054398:  view genomic region     (about GC identifiers)

Start:
54,398,474 bp from pter      End:
54,406,080 bp from pter
Size:
7,607 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRAA_HUMAN, P12544 (See protein sequence)
Recommended Name: Granzyme A precursor  
Size: 262 amino acids; 28999 Da
Subunit: Homodimer; disulfide-linked. Interacts with APEX1
Subcellular location: Isoform alpha: Secreted. Cytoplasmic granule
Caution: Exons 1a and 1b of the sequence reported in PubMed:17180578 are of human origin, however exon 2 shows
strong similarity to the rat sequence
3 PDB 3D structures from and Proteopedia for GZMA:
1HF1 (3D)        1OP8 (3D)        1ORF (3D)    
Secondary accessions: A4PHN1 Q6IB36
Alternative promoter usage: 2 isoforms:  P12544-1   P12544-2   

Explore the universe of human proteins at neXtProt for GZMA: NX_P12544

Explore proteomics data for GZMA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12544

  • 3 DME Specific Peptides for GZMA (P12544)
     GDSGSPL  VLTAAHC  WVLTAAH 

    GZMA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GZMA Protein Expression
    REFSEQ proteins: NP_006135.1  
    ENSEMBL proteins: 
     ENSP00000274306  

    Human Recombinant Protein Products for GZMA: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for GZMA (Granzyme A)
    Enzo Life Sciences proteins for GZMA
    OriGene Purified Protein for GZMA
    OriGene Protein Over-expression Lysate for GZMA
    OriGene MassSpec for GZMA 
    OriGene Custom Protein Services for GZMA
    GenScript Custom Purified and Recombinant Proteins Services for GZMA
    Novus Biologicals GZMA Proteins
    Novus Biologicals GZMA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GZMA 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse TAS12524539
    GO:0005576extracellular region IEA--
    GO:0005634nucleus TAS11909973

    GZMA for ontologies           About GeneDecksing



    GZMA Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for GZMA (Granzyme A)
    Cell Signaling Technology (CST) Antibodies for GZMA 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GZMA
    GenScript Custom Superior Antibodies Services for GZMA
    Novus Biologicals GZMA Antibodies
    Abcam antibodies for GZMA
    Cloud-Clone Corp. Antibodies for GZMA 
    ThermoFisher Antibodies for GZMA
    LSBio Antibodies in human, mouse, rat for GZMA 

    Assay Products for GZMA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GZMA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GZMA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GZMA 
    Cloud-Clone Corp. CLIAs for GZMA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P12544

    ProtoNet protein and cluster: P12544

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: GRAA_HUMAN, P12544
    Similarity: Belongs to the peptidase S1 family. Granzyme subfamily
    Similarity: Contains 1 peptidase S1 domain


    GZMA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRAA_HUMAN, P12544
    Function: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys
    or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis
    Catalytic activity: Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential
    cleavage: -Arg- -Xaa-, -Lys- -Xaa- >> -Phe- -Xaa- in small molecule substrates
    Induction: Dexamethasone (DEX) induces expression of isoform beta and represses expression of isoform alpha. The
    alteration in expression is mediated by binding of glucocorticoid receptor to independent promoters adjacent to
    the alternative first exons of isoform alpha and isoform beta

         Genatlas biochemistry entry for GZMA:
    cytotoxic T-lymphocyte-associated granule serine protease 3,Hanuka factor,lymphocyte tryptase 1

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.781

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IDA12819770
    GO:0005515protein binding IPI12524539
    GO:0008236serine-type peptidase activity ----
    GO:0042803protein homodimerization activity IDA12819770
         
    GZMA for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gzma):
     hematopoietic system  immune system  mortality/aging  tumorigenesis 

    GZMA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GZMA: Gzmatm1Ley Gzmatm1Simn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GZMA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GZMA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GZMA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GZMA 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GZMA
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GZMA
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GZMA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GZMA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GZMA
    Sirion Biotech Customized adenovirus for overexpression of GZMA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GZMA (see all 8)
    OriGene ORF clones in mouse, rat for GZMA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GZMA (NM_006144)
    Sino Biological Human cDNA Clone for GZMA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GZMA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GZMA
    Sirion Biotech Customized lentivirus for stable overexpression of GZMA 
                         Customized lentivirus expression plasmids for stable overexpression of GZMA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GZMA
    Search LifeMap BioReagents cell lines for GZMA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GZMA About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Granzyme Pathway
    Granzyme Pathway0.42
    2Class A/1 (Rhodopsin-like receptors)
    Neuroactive ligand-receptor interaction0.37
    3Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-9 Pathway0.36
    4Immune response IL-12-induced IFN-gamma production
    IL12-mediated signaling events0.33
    5IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GZMA
        IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GZMA
        IL-9 Pathway
    Granzyme-A Pathway
    Granzyme Pathway

    2 Cell Signaling Technology (CST) Pathways for GZMA
        Apoptosis and Autophagy
    Lymphocyte Signaling

    1 BioSystems Pathway for GZMA
        IL12-mediated signaling events



    1         Kegg Pathway  (Kegg details for GZMA):
        Neuroactive ligand-receptor interaction


    GZMA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GZMA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/38 Interacting proteins for GZMA (P125443 ENSP000002743064) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=1 STRING: ENSP00000406359
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006915apoptotic process TAS12524539
    GO:0006922cleavage of lamin involved in execution phase of apoptosis IDA11331782
    GO:0006955immune response TAS12524539
    GO:0019835cytolysis IEA--

    GZMA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GZMA for compounds           About GeneDecksing

    EMD Millipore small molecules for GZMA:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for GZMA

    Browse Tocris compounds for GZMA (GRAA)

    10/16 Novoseek inferred chemical compound relationships for GZMA gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3,4-dichloroisocoumarin 74.4 1 9036942 (1)
    serine 70.5 43 7923921 (2), 8835202 (2), 8288245 (2), 8305526 (1) (see all 28)
    isocoumarin 58.7 1 1998680 (1)
    ddvp 58.6 9 16002202 (4), 16873099 (1), 18063463 (1)
    chromium 33.6 3 16873099 (1), 15622622 (1), 16002202 (1)
    mannose 6-phosphate 30.8 7 8432729 (5)
    rantes 23.7 4 15929698 (2), 17314518 (1), 9495345 (1)
    ionomycin 23.5 1 9538144 (1)
    agarose 0 1 8258716 (1)
    oxygen 0 5 15780992 (1), 15286980 (1), 18485862 (1)

    Search CenterWatch for drugs/clinical trials and news about GZMA / GRAA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GZMA gene: 
    NM_006144.3  

    Unigene Cluster for GZMA:

    Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
    Hs.90708  [show with all ESTs]
    Unigene Representative Sequence: BM917804
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274306(uc003jpm.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GZMA
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GZMA
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GZMA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GZMA
    Clone
    Products:
         
    OriGene clones in human, mouse for GZMA (see all 8)
    OriGene ORF clones in mouse, rat for GZMA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GZMA (NM_006144)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GZMA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GZMA
    Sirion Biotech Customized lentivirus for stable overexpression of GZMA 
                         Customized lentivirus expression plasmids for stable overexpression of GZMA 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GZMA
    OriGene qSTAR qPCR primer pairs in human, mouse for GZMA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GZMA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GZMA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GZMA

    Additional mRNA sequence: 

    BC015739.1 CR456968.1 M18737.1 

    5 DOTS entries:

    DT.210372  DT.92443776  DT.92443767  DT.95098368  DT.92443770 

    24/115 AceView cDNA sequences (see all 115):

    BG190565 BG181621 BQ012679 CD368966 CA444285 BG190044 BG744784 BG211181 
    NM_006144 BG217600 BQ010949 CR456968 BF591192 CA310197 BG202305 BG207530 
    BG220601 AI307784 AA283007 AI767737 BC015739 AI275889 AW612415 BG743936 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GZMA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                                          
    SP2:              -                           


    ECgene alternative splicing isoforms for GZMA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GZMA expression in normal human tissues (normalized intensities)      GZMA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTAAAAA
    GZMA Expression
    About this image


    GZMA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             T-Cytotoxic Cells Thymus
             Peripheral blood Pan-T Cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Cord Blood CD133- Cells   
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Uncategorized (Uncategorized)
             PureStem Progenitor EN7

    See GZMA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GZMA

    SOURCE GeneReport for Unigene cluster: Hs.90708
        SABiosciences Expression via Pathway-Focused PCR Array including GZMA: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GZMA
    OriGene qSTAR qPCR primer pairs in human, mouse for GZMA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GZMA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GZMA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GZMA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GZMA gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gzma1 , 5 granzyme A1, 5 76.67(n)1
    68.85(a)1
      13 (63.93 cM)5
    149381  NM_010370.21  NP_034500.11 
     1130938275 
    chicken
    (Gallus gallus)
    Aves GZMA1 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated more 61.87(n)
    54(a)
      395108  NM_204457.1  NP_989788.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    48(a)
    45(a)
    many → 1
    many → 1
    2(2700978-2709873)
    2(2693812-2698285)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-21e2.116
    si:dkey-78l4.46
    (see all 25)
    si:dkey-78l4.4
    (see all 25)
    37(a)
    36(a)
    (see all 25)
    possible ortholog
    possible ortholog
    (see all 25)
    22(19582517-19584109)
    22(19733409-19736079)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG129516
    CG167496
    (see all 3)
    --
    24(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3R(5154998-5156047)
    3R(5156607-5157617)


    ENSEMBL Gene Tree for GZMA (if available)
    TreeFam Gene Tree for GZMA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GZMA gene
    GZMH2  PRTN32  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  
    AZU12  GZMM2  GZMB2  
    18/86 SIMAP similar genes for GZMA using alignment to 1 protein entry:     GRAA_HUMAN(see all similar genes):
    GZMK    GZMB    CFD    DF    GZMH    CMA1
    KLK13    KLK14    KLK9    CELA1    CTSG    ELANE
    KLK7    KLK8    CTRB1    CTRB2    CTRL    KLK12

    GZMA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GZMA
    PGOHUM00000235592


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/244 SNPs in GZMA are shown (see all 244)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0242914
    ----see VAR_0242912 M T mis40--------
    rs100789861,2
    C--54333517(+) agggaC/Tgtgaa 1 -- us2k10--------
    rs1822789381,2
    --54333518(+) GGGATA/GTGAAG 1 -- us2k10--------
    rs1409884261,2
    --54333559(+) CTCAAC/TGAAAT 1 -- us2k10--------
    rs1869364951,2
    --54333809(+) TACCTA/GACTTC 1 -- us2k10--------
    rs1502296001,2
    C--54333911(+) ACACTC/GTAAAT 1 -- us2k10--------
    rs1929836791,2
    --54333924(+) GTGACA/CTTTAT 1 -- us2k10--------
    rs1851387021,2
    --54334178(+) CAGGGG/TTCTCA 1 -- us2k10--------
    rs1388120151,2
    --54334319(+) TGTATC/TGGAGA 1 -- us2k10--------
    rs1494982421,2
    --54334320(+) GTATCA/GGAGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GZMA (54398474 - 54406080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GZMA:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2503041CNV Deletion19546169
    nsv4833CNV Loss18451855
    nsv830302CNV Gain17160897
    nsv830301CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GZMA
    DNA2.0 Custom Variant and Variant Library Synthesis for GZMA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 140050    OMIM disorders: --

    20/31 diseases for GZMA (see all 31):    About MalaCards
    polymyositis    cutaneous leishmaniasis    chediak-higashi syndrome    pulmonary sarcoidosis
    cytomegalovirus infection    pulmonary tuberculosis    sjogren's syndrome    myositis
    leishmaniasis    sarcoidosis    osteoarthritis    vasculitis
    chronic obstructive pulmonary disease    bronchiolitis    cholera    rheumatoid arthritis
    cytochrome p450    thrombocytopenia    acute lymphoblastic leukemia    myopathy


    GZMA for disorders           About GeneDecksing

    10/19 Novoseek inferred disease relationships for GZMA gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myositis 27.3 1 7919969 (1)
    sjogrens syndrome 25 2 8030547 (1), 7904795 (1)
    tumors 21.6 15 12847210 (3), 11069717 (2), 8959642 (1), 12428227 (1) (see all 11)
    virus infection 18.8 4 10998317 (1), 8929545 (1), 16208762 (1)
    necrosis 16.3 8 8959642 (1), 12428227 (1), 8517482 (1), 9538144 (1) (see all 8)
    lymphoproliferative disorders 16.1 1 10892713 (1)
    rheumatoid arthritis 15.8 7 7923921 (2), 1731326 (2), 7536415 (1), 10337032 (1) (see all 5)
    cmv infection 15.5 1 15848677 (1)
    hiv infections 11.9 4 10449281 (1), 10716374 (1), 12001057 (1)
    polymyositis 11.8 1 8268727 (1)

    Genetic Association Database (GAD): GZMA
    Human Genome Epidemiology (HuGE) Navigator: GZMA (4 documents)

    Export disorders for GZMA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GZMA gene, integrated from 9 sources (see all 247):
    (articles sorted by number of sources associating them with GZMA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of three serine esterases isolated from human IL-2 activated killer cells. (PubMed id 3262682)1, 2, 3 Hameed A.... Podack E.R. (1988)
    2. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. (PubMed id 12524539)1, 2, 9 Fan Z.... Lieberman J. (2003)
    3. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. (PubMed id 12819769)1, 2, 9 Bell J.K....Craik C.S. (2003)
    4. Crystal structure of the apoptosis-inducing human granzyme A dimer. (PubMed id 12819770)1, 2, 9 Hink-Schauer C....Jenne D.E. (2003)
    5. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    6. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes. (PubMed id 3263427)1, 2 Kraehenbuhl O.... Tschopp J. (1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3001 HGNC: 4708 AceView: GZMA Ensembl:ENSG00000145649 euGenes: HUgn3001
    ECgene: GZMA Kegg: 3001 H-InvDB: GZMA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GZMA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GZMA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GZMA gene:
    Search GeneIP for patents involving GZMA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for GZMA
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for GZMA (Granzyme A)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for GZMA (Granzyme A)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GZMA  
     OriGene qPCR primer pairs and template standards for GZMA   OriGene Protein Over-expression Lysate for GZMA  
     OriGene MassSpec something-or-other for GZMA   OriGene clones in human, mouse for GZMA  
     OriGene qSTAR qPCR primer pairs in human, mouse for GZMA   OriGene Purified Protein for GZMA  
     OriGene ORF clones in mouse, rat for GZMA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GZMA   OriGene Custom Protein Services for GZMA  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GZMA
     QIAGEN SeqTarget long-range PCR primers for resequencing GZMA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GZMA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GZMA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GZMA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GZMA
     GenScript Custom Purified and Recombinant Proteins Services for GZMA GenScript cDNA clones with any tag delivered in your preferred vector for GZMA
     GenScript Custom Assay Services for GZMA GenScript Custom Superior Antibodies Services for GZMA
     GenScript Custom overexpressing Cell Line Services for GZMA CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for GZMA 

     Regulatory tfbs in GZMA promoter
     Search Chromatin IP Primers for GZMA
     RT2 qPCR Primer Assay in human, mouse, rat GZMA
     GNC Network for GZMA
     SABiosciences PCR Arrays including human, mouse, rat GZMA
     Search Tocris compounds for GZMA (GRAA)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for GZMA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for GZMA
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GZMA antibodies
     GZMA proteins
     GZMA lysates
     Antibodies for GZMA
     See all of Abcam's Antibodies, Kits and Proteins for GZMA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GZMA
     Antibodies for GZMA
     ELISAs for GZMA
     CLIAs for GZMA
     Search LifeMap BioReagents cell lines for GZMA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GZMA
     Browse SwitchGear 3'UTR luciferase reporter plasmids for GZMA
     SwitchGear Promoter luciferase reporter plasmids for GZMA
     ThermoFisher Antibodies for GZMA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GZMA
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GZMA
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GZMA
    Customized:
     lentivirus for stable overexpression of GZMA
     lentivirus expression plasmids for stable overexpression of GZMA
     adenovirus for overexpression of GZMA
     LSBio Antibodies in human, mouse, rat for GZMA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GZMA gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4