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Aliases for GZF1 Gene

Aliases for GZF1 Gene

  • GDNF Inducible Zinc Finger Protein 1 2 3
  • Zinc Finger Protein 336 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 23 3 4
  • ZNF336 3 4
  • ZBTB23 3 4
  • GDNF-Inducible Zinc Finger Protein 1 5

External Ids for GZF1 Gene

Previous HGNC Symbols for GZF1 Gene

  • ZNF336

Previous GeneCards Identifiers for GZF1 Gene

  • GC20P023291

Summaries for GZF1 Gene

GeneCards Summary for GZF1 Gene

GZF1 (GDNF Inducible Zinc Finger Protein 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding.

UniProtKB/Swiss-Prot for GZF1 Gene

  • Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5-TGCGCN[TG][CA]TATA-3). May be regulating VSX2/HOX10 expression.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZF1 Gene

Genomics for GZF1 Gene

Regulatory Elements for GZF1 Gene

Enhancers for GZF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GZF1 on UCSC Golden Path with GeneCards custom track

Promoters for GZF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GZF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GZF1 Gene

Chromosome:
20
Start:
23,361,639 bp from pter
End:
23,373,063 bp from pter
Size:
11,425 bases
Orientation:
Plus strand

Genomic View for GZF1 Gene

Genes around GZF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GZF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZF1 Gene

Proteins for GZF1 Gene

  • Protein details for GZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H116-GZF1_HUMAN
    Recommended name:
    GDNF-inducible zinc finger protein 1
    Protein Accession:
    Q9H116
    Secondary Accessions:
    • A8K199
    • B2RBC3
    • B3KPL4
    • B4DF58
    • D3DW39
    • Q54A22
    • Q96N08
    • Q9BQK9
    • Q9H117
    • Q9H6W6

    Protein attributes for GZF1 Gene

    Size:
    711 amino acids
    Molecular mass:
    80492 Da
    Quaternary structure:
    • Interacts with NCL.
    SequenceCaution:
    • Sequence=BAB15134.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GZF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GZF1 Gene

Proteomics data for GZF1 Gene at MOPED

Post-translational modifications for GZF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GZF1 Gene

No data available for DME Specific Peptides for GZF1 Gene

Domains & Families for GZF1 Gene

Gene Families for GZF1 Gene

Protein Domains for GZF1 Gene

Suggested Antigen Peptide Sequences for GZF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H116

UniProtKB/Swiss-Prot:

GZF1_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with GZF1: view

Function for GZF1 Gene

Molecular function for GZF1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5-TGCGCN[TG][CA]TATA-3). May be regulating VSX2/HOX10 expression.
UniProtKB/Swiss-Prot Induction:
By GDNF.

Gene Ontology (GO) - Molecular Function for GZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 16049025
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16049025
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 16049025
genes like me logo Genes that share ontologies with GZF1: view
genes like me logo Genes that share phenotypes with GZF1: view

Animal Model Products

miRNA for GZF1 Gene

miRTarBase miRNAs that target GZF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GZF1 Gene

Localization for GZF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZF1 Gene

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Nuclear localization depends upon NCL.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GZF1 Gene COMPARTMENTS Subcellular localization image for GZF1 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for GZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with GZF1: view

Pathways & Interactions for GZF1 Gene

SuperPathways for GZF1 Gene

No Data Available

Interacting Proteins for GZF1 Gene

Gene Ontology (GO) - Biological Process for GZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with GZF1: view

No data available for Pathways by source and SIGNOR curated interactions for GZF1 Gene

Drugs & Compounds for GZF1 Gene

No Compound Related Data Available

Transcripts for GZF1 Gene

Unigene Clusters for GZF1 Gene

GDNF-inducible zinc finger protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GZF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - -
SP2: -
SP3: - - - - - - - -
SP4: - -
SP5:
SP6: - -
SP7:
SP8:
SP9: - -

Relevant External Links for GZF1 Gene

GeneLoc Exon Structure for
GZF1
ECgene alternative splicing isoforms for
GZF1

Expression for GZF1 Gene

mRNA expression in normal human tissues for GZF1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GZF1 Gene



SOURCE GeneReport for Unigene cluster for GZF1 Gene Hs.709462

mRNA Expression by UniProt/SwissProt for GZF1 Gene

Q9H116-GZF1_HUMAN
Tissue specificity: Expressed in adult brain, heart, skeletal muscle, kidney and liver. Also detected in fetal brain and kidney, and at lower levels in fetal lung and liver.
genes like me logo Genes that share expression patterns with GZF1: view

Protein tissue co-expression partners for GZF1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for GZF1 Gene

Orthologs for GZF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GZF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GZF1 35
  • 82.98 (n)
  • 82.6 (a)
GZF1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GZF1 35
  • 84.35 (n)
  • 85.15 (a)
GZF1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gzf1 35
  • 81.75 (n)
  • 82.84 (a)
Gzf1 16
Gzf1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GZF1 35
  • 99.2 (n)
  • 98.73 (a)
GZF1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gzf1 35
  • 82.03 (n)
  • 83.12 (a)
oppossum
(Monodelphis domestica)
Mammalia GZF1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GZF1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF568 35
  • 74.61 (n)
  • 78.77 (a)
GZF1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gzf1 35
  • 64.46 (n)
  • 62.89 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33585 35
zebrafish
(Danio rerio)
Actinopterygii hnrnpa0l 36
  • 41 (a)
OneToOne
Species with no ortholog for GZF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GZF1 Gene

ENSEMBL:
Gene Tree for GZF1 (if available)
TreeFam:
Gene Tree for GZF1 (if available)

Paralogs for GZF1 Gene

(289) SIMAP similar genes for GZF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GZF1: view

No data available for Paralogs for GZF1 Gene

Variants for GZF1 Gene

Sequence variations from dbSNP and Humsavar for GZF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6048760 -, -, - 23,365,207(+) GGAGC(A/C/G/T)GGTTT reference, missense
rs3810574 - 23,364,952(+) CAGCA(A/G)TGGCA reference, missense
rs6114068 - 23,365,337(+) TTTAA(G/T)TGCAG reference, missense
rs6048766 - 23,370,304(+) CTGCT(A/G)ACACA downstream-variant-500B, reference, synonymous-codon, missense
VAR_064718 -

Variation tolerance for GZF1 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GZF1 Gene

Disorders for GZF1 Gene

Relevant External Links for GZF1

Genetic Association Database (GAD)
GZF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GZF1

No disorders were found for GZF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GZF1 Gene

Publications for GZF1 Gene

  1. GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region. (PMID: 16049025) Morinaga T. … Takahashi M. (Nucleic Acids Res. 2005) 2 3 4 23 67
  2. Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation. (PMID: 17674968) Dambara A. … Takahashi M. (Exp. Cell Res. 2007) 3 23
  3. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. (PMID: 14522971) Fukuda N. … Takahashi M. (J. Biol. Chem. 2003) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney. (PMID: 21292309) Saito S. … Takahashi M. (Hum. Pathol. 2011) 3

Products for GZF1 Gene

Sources for GZF1 Gene

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