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Aliases for GZF1 Gene

Aliases for GZF1 Gene

  • GDNF Inducible Zinc Finger Protein 1 2 3 5
  • Zinc Finger Protein 336 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 23 3 4
  • ZNF336 3 4
  • ZBTB23 3 4
  • GDNF-Inducible Zinc Finger Protein 1 3

External Ids for GZF1 Gene

Previous HGNC Symbols for GZF1 Gene

  • ZNF336

Previous GeneCards Identifiers for GZF1 Gene

  • GC20P023291

Summaries for GZF1 Gene

GeneCards Summary for GZF1 Gene

GZF1 (GDNF Inducible Zinc Finger Protein 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding.

UniProtKB/Swiss-Prot for GZF1 Gene

  • Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5-TGCGCN[TG][CA]TATA-3). May be regulating VSX2/HOX10 expression.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZF1 Gene

Genomics for GZF1 Gene

Regulatory Elements for GZF1 Gene

Enhancers for GZF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G023628 1.5 Ensembl ENCODE dbSUPER 5 +268.0 267951 2.3 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 TCF12 SLC30A9 ZNF143 FOS CST3 CST9 GZF1 ENSG00000270001
GH20G023141 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3.5 -209.6 -209630 22.0 HDGF FOXA2 PKNOX1 MLX CREB3L1 ARID4B DMAP1 YBX1 SLC30A9 ZNF766 CD93 THBD NXT1 ENSG00000230387 GZF1 CST3 ENSG00000279164 LOC100505664
GH20G023080 1.5 FANTOM5 ENCODE dbSUPER 2.7 -277.1 -277142 8.0 PKNOX1 ZFP64 RAD21 TCF12 GATA2 EGR1 SCRT2 FOS RELB CREM CD93 THBD GZF1 ENSG00000279447
GH20G023366 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.6 +5.0 5018 1.3 HDAC1 ATF1 AGO1 TCF12 RELB PAF1 JUNB USF2 TBX21 POLR2H NAPB CSTL1 CD93 GZF1 THBD RNA5SP479 GC20M023381
GH20G023102 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.7 -256.6 -256602 5.9 CTCF JUN ETV1 TAL1 MAX ZIC2 RAD21 YY1 TCF12 EGR1 CD93 THBD GZF1 LINC00656
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GZF1 on UCSC Golden Path with GeneCards custom track

Promoters for GZF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000297781 461 1801 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC

Genomic Location for GZF1 Gene

Chromosome:
20
Start:
23,361,639 bp from pter
End:
23,373,063 bp from pter
Size:
11,425 bases
Orientation:
Plus strand

Genomic View for GZF1 Gene

Genes around GZF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GZF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZF1 Gene

Proteins for GZF1 Gene

  • Protein details for GZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H116-GZF1_HUMAN
    Recommended name:
    GDNF-inducible zinc finger protein 1
    Protein Accession:
    Q9H116
    Secondary Accessions:
    • A8K199
    • B2RBC3
    • B3KPL4
    • B4DF58
    • D3DW39
    • Q54A22
    • Q96N08
    • Q9BQK9
    • Q9H117
    • Q9H6W6

    Protein attributes for GZF1 Gene

    Size:
    711 amino acids
    Molecular mass:
    80492 Da
    Quaternary structure:
    • Interacts with NCL.
    SequenceCaution:
    • Sequence=BAB15134.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GZF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GZF1 Gene

Post-translational modifications for GZF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GZF1 Gene

Domains & Families for GZF1 Gene

Gene Families for GZF1 Gene

Protein Domains for GZF1 Gene

Suggested Antigen Peptide Sequences for GZF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H116

UniProtKB/Swiss-Prot:

GZF1_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with GZF1: view

Function for GZF1 Gene

Molecular function for GZF1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5-TGCGCN[TG][CA]TATA-3). May be regulating VSX2/HOX10 expression.
UniProtKB/Swiss-Prot Induction:
By GDNF.

Gene Ontology (GO) - Molecular Function for GZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 16049025
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16049025
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 16049025
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IMP 16049025
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with GZF1: view
genes like me logo Genes that share phenotypes with GZF1: view

Animal Model Products

CRISPR Products

miRNA for GZF1 Gene

miRTarBase miRNAs that target GZF1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GZF1 Gene

Localization for GZF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZF1 Gene

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Nuclear localization depends upon NCL.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GZF1 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for GZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with GZF1: view

Pathways & Interactions for GZF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 16049025
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 16049025
genes like me logo Genes that share ontologies with GZF1: view

No data available for Pathways by source and SIGNOR curated interactions for GZF1 Gene

Drugs & Compounds for GZF1 Gene

No Compound Related Data Available

Transcripts for GZF1 Gene

Unigene Clusters for GZF1 Gene

GDNF-inducible zinc finger protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GZF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - -
SP2: -
SP3: - - - - - - - -
SP4: - -
SP5:
SP6: - -
SP7:
SP8:
SP9: - -

Relevant External Links for GZF1 Gene

GeneLoc Exon Structure for
GZF1
ECgene alternative splicing isoforms for
GZF1

Expression for GZF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GZF1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GZF1 Gene



Protein tissue co-expression partners for GZF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GZF1 Gene:

GZF1

SOURCE GeneReport for Unigene cluster for GZF1 Gene:

Hs.709462

mRNA Expression by UniProt/SwissProt for GZF1 Gene:

Q9H116-GZF1_HUMAN
Tissue specificity: Expressed in adult brain, heart, skeletal muscle, kidney and liver. Also detected in fetal brain and kidney, and at lower levels in fetal lung and liver.

Evidence on tissue expression from TISSUES for GZF1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GZF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GZF1 Gene

Orthologs for GZF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GZF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GZF1 34 35
  • 99.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GZF1 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GZF1 34 35
  • 84.35 (n)
cow
(Bos Taurus)
Mammalia GZF1 34 35
  • 82.98 (n)
rat
(Rattus norvegicus)
Mammalia Gzf1 34
  • 82.03 (n)
mouse
(Mus musculus)
Mammalia Gzf1 34 16 35
  • 81.75 (n)
oppossum
(Monodelphis domestica)
Mammalia GZF1 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves GZF1 35
  • 75 (a)
OneToOne
ZNF568 34
  • 74.61 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gzf1 34
  • 64.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33585 34
zebrafish
(Danio rerio)
Actinopterygii hnrnpa0l 35
  • 41 (a)
OneToOne
Species where no ortholog for GZF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GZF1 Gene

ENSEMBL:
Gene Tree for GZF1 (if available)
TreeFam:
Gene Tree for GZF1 (if available)

Paralogs for GZF1 Gene

(289) SIMAP similar genes for GZF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GZF1: view

No data available for Paralogs for GZF1 Gene

Variants for GZF1 Gene

Sequence variations from dbSNP and Humsavar for GZF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000080822 -- 23,372,929(+) AGACC(C/T)TTATT nc-transcript-variant, utr-variant-3-prime
rs1000133114 -- 23,372,742(+) GGAAA(G/T)TGGCC nc-transcript-variant, utr-variant-3-prime
rs1000252088 -- 23,367,511(+) TCAAC(C/T)CTGGT intron-variant
rs1000347229 -- 23,367,972(+) TTAGA(A/C)ACCAC intron-variant
rs1000807141 -- 23,361,557(+) CAGGG(C/T)GGGGG upstream-variant-2KB

Variation tolerance for GZF1 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GZF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GZF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GZF1 Gene

Disorders for GZF1 Gene

Relevant External Links for GZF1

Genetic Association Database (GAD)
GZF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GZF1

No disorders were found for GZF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GZF1 Gene

Publications for GZF1 Gene

  1. GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region. (PMID: 16049025) Morinaga T. … Takahashi M. (Nucleic Acids Res. 2005) 2 3 4 22 64
  2. Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation. (PMID: 17674968) Dambara A. … Takahashi M. (Exp. Cell Res. 2007) 3 4 22 64
  3. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. (PMID: 14522971) Fukuda N. … Takahashi M. (J. Biol. Chem. 2003) 2 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for GZF1 Gene

Sources for GZF1 Gene

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