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Aliases for GZF1 Gene

Aliases for GZF1 Gene

  • GDNF-Inducible Zinc Finger Protein 1 2 3
  • Zinc Finger Protein 336 2 3 4
  • ZNF336 3 4 6
  • Zinc Finger And BTB Domain-Containing Protein 23 3 4
  • ZBTB23 3 4

External Ids for GZF1 Gene

Previous Symbols for GZF1 Gene

  • ZNF336

Summaries for GZF1 Gene

GeneCards Summary for GZF1 Gene

GZF1 (GDNF-Inducible Zinc Finger Protein 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot for GZF1 Gene

  • Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5-TGCGCN[TG][CA]TATA-3). May be regulating VSX2/HOX10 expression.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GZF1 Gene

Genomics for GZF1 Gene

Genomic Location for GZF1 Gene

Start:
23,362,132 bp from pter
End:
23,373,063 bp from pter
Size:
10,932 bases
Orientation:
Plus strand

Genomic View for GZF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GZF1 Gene

Regulatory Elements for GZF1 Gene

Proteins for GZF1 Gene

  • Protein details for GZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H116-GZF1_HUMAN
    Recommended name:
    GDNF-inducible zinc finger protein 1
    Protein Accession:
    Q9H116
    Secondary Accessions:
    • A8K199
    • B2RBC3
    • B3KPL4
    • B4DF58
    • D3DW39
    • Q54A22
    • Q96N08
    • Q9BQK9
    • Q9H117
    • Q9H6W6

    Protein attributes for GZF1 Gene

    Size:
    711 amino acids
    Molecular mass:
    80492 Da
    Quaternary structure:
    • Interacts with NCL.
    SequenceCaution:
    • Sequence=BAB15134.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GZF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GZF1 Gene

Proteomics data for GZF1 Gene at MOPED

Post-translational modifications for GZF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GZF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GZF1 Gene

Domains for GZF1 Gene

Gene Families for GZF1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

Protein Domains for GZF1 Gene

UniProtKB/Swiss-Prot:

GZF1_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q9H116
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9H116
Similarity:
  • Contains 10 C2H2-type zinc fingers.:
    • Q9H116
genes like me logo Genes that share domains with GZF1: view

Function for GZF1 Gene

Molecular function for GZF1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5-TGCGCN[TG][CA]TATA-3). May be regulating VSX2/HOX10 expression.
UniProtKB/Swiss-Prot Induction: By GDNF.

Gene Ontology (GO) - Molecular Function for GZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 16049025
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16049025
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IMP 16049025
GO:0001206 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IMP 16049025
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GZF1: view

Phenotypes for GZF1 Gene

GenomeRNAi human phenotypes for GZF1:
genes like me logo Genes that share phenotypes with GZF1: view

miRNA for GZF1 Gene

miRTarBase miRNAs that target GZF1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GZF1 Gene

Localization for GZF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GZF1 Gene

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Nuclear localization depends upon NCL.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GZF1 Gene COMPARTMENTS Subcellular localization image for GZF1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for GZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with GZF1: view

Pathways for GZF1 Gene

SuperPathways for GZF1 Gene

No Data Available

Interacting Proteins for GZF1 Gene

Gene Ontology (GO) - Biological Process for GZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 16049025
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 16049025
genes like me logo Genes that share ontologies with GZF1: view

No data available for Pathways by source for GZF1 Gene

Transcripts for GZF1 Gene

Unigene Clusters for GZF1 Gene

GDNF-inducible zinc finger protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GZF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - -
SP2: -
SP3: - - - - - - - -
SP4: - -
SP5:
SP6: - -
SP7:
SP8:
SP9: - -

Relevant External Links for GZF1 Gene

GeneLoc Exon Structure for
GZF1
ECgene alternative splicing isoforms for
GZF1

Expression for GZF1 Gene

mRNA expression in normal human tissues for GZF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GZF1 Gene

SOURCE GeneReport for Unigene cluster for GZF1 Gene Hs.709462

mRNA Expression by UniProt/SwissProt for GZF1 Gene

Q9H116-GZF1_HUMAN
Tissue specificity: Expressed in adult brain, heart, skeletal muscle, kidney and liver. Also detected in fetal brain and kidney, and at lower levels in fetal lung and liver.
genes like me logo Genes that share expressions with GZF1: view

Orthologs for GZF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GZF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GZF1 36
  • 99.2 (n)
  • 98.73 (a)
GZF1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GZF1 36
  • 82.98 (n)
  • 82.6 (a)
GZF1 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GZF1 36
  • 84.35 (n)
  • 85.15 (a)
GZF1 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gzf1 36
  • 81.75 (n)
  • 82.84 (a)
Gzf1 16
Gzf1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GZF1 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GZF1 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gzf1 36
  • 82.03 (n)
  • 83.12 (a)
chicken
(Gallus gallus)
Aves GZF1 37
  • 75 (a)
OneToOne
ZNF568 36
  • 74.61 (n)
  • 78.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33585 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gzf1 36
  • 64.46 (n)
  • 62.89 (a)
zebrafish
(Danio rerio)
Actinopterygii hnrnpa0l 37
  • 41 (a)
OneToOne
Species with no ortholog for GZF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GZF1 Gene

ENSEMBL:
Gene Tree for GZF1 (if available)
TreeFam:
Gene Tree for GZF1 (if available)

Paralogs for GZF1 Gene

Selected SIMAP similar genes for GZF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GZF1: view

No data available for Paralogs for GZF1 Gene

Variants for GZF1 Gene

Sequence variations from dbSNP and Humsavar for GZF1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs7988 -- 23,372,048(+) TACAG(A/C)ACAAA utr-variant-3-prime
rs12349 -- 23,371,843(+) TCCAG(A/G)ATGAA utr-variant-3-prime
rs743024 -- 23,361,839(+) CGGAA(C/T)GGACG upstream-variant-2KB
rs999072 -- 23,366,916(+) GTAAA(C/T)GATTT intron-variant
rs1003417 -- 23,367,370(-) AAAAA(A/T)TTTCG intron-variant

Relevant External Links for GZF1 Gene

HapMap Linkage Disequilibrium report
GZF1

No data available for Structural Variations from Database of Genomic Variants (DGV) for GZF1 Gene

Disorders for GZF1 Gene

Relevant External Links for GZF1

Genetic Association Database (GAD)
GZF1
genes like me logo Genes that share disorders with GZF1: view

No data available for UniProtKB/Swiss-Prot for GZF1 Gene

Publications for GZF1 Gene

  1. GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region. (PMID: 16049025) Morinaga T. … Takahashi M. (Nucleic Acids Res. 2005) 2 3 4 23
  2. Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation. (PMID: 17674968) Dambara A. … Takahashi M. (Exp. Cell Res. 2007) 3 4 23
  3. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. (PMID: 14522971) Fukuda N. … Takahashi M. (J. Biol. Chem. 2003) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for GZF1 Gene

Sources for GZF1 Gene

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