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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GZF1 Gene

protein-coding   GIFtS: 48
GCID: GC20P023342

GDNF-Inducible Zinc Finger Protein 1

(Previous name: zinc finger protein 336)
(Previous symbol: ZNF336)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
GDNF-Inducible Zinc Finger Protein 11 2
Zinc Finger Protein 3361 2 3
ZNF3361 2 3
Zinc Finger And BTB Domain-Containing Protein 232 3
ZBTB232 3

External Ids:    HGNC: 158081   Entrez Gene: 644122   Ensembl: ENSG000001258127   OMIM: 6138425   UniProtKB: Q9H1163   

Export aliases for GZF1 gene to outside databases

Previous GC identifer: GC20P023291


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GZF1 Gene: 
GZF1 (GDNF-inducible zinc finger protein 1) is a protein-coding gene. Diseases associated with GZF1 include membranous glomerulonephritis, and glomerulonephritis. GO annotations related to this gene include sequence-specific DNA binding and zinc ion binding.

UniProtKB/Swiss-Prot: GZF1_HUMAN, Q9H116
Function: Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus:
5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GZF1 gene promoter:
         Pax-5   Nkx2-5   LCR-F1   POU3F2   C/EBPalpha   Max   FOXO1a   FOXO1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGZF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GZF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GZF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.21   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11.21

GZF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GZF1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P023342:  view genomic region     (about GC identifiers)

Start:
23,342,787 bp from pter      End:
23,353,700 bp from pter
Size:
10,914 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GZF1_HUMAN, Q9H116 (See protein sequence)
Recommended Name: GDNF-inducible zinc finger protein 1  
Size: 711 amino acids; 80492 Da
Subunit: Interacts with NCL
Subcellular location: Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Nuclear localization depends upon NCL
Sequence caution: Sequence=BAB15134.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB71107.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K199 B2RBC3 B3KPL4 D3DW39 Q54A22 Q96N08 Q9BQK9 Q9H117 Q9H6W6

Explore the universe of human proteins at neXtProt for GZF1: NX_Q9H116

Explore proteomics data for GZF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H116

  • GZF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GZF1 Protein Expression
    REFSEQ proteins: NP_071927.1  
    ENSEMBL proteins: 
     ENSP00000338290   ENSP00000410009   ENSP00000366250   ENSP00000445458   ENSP00000445118  

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    Cloud-Clone Corp. Proteins for GZF1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IEA--

    GZF1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9H116

    ProtoNet protein and cluster: Q9H116

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: GZF1_HUMAN, Q9H116
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 10 C2H2-type zinc fingers


    GZF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GZF1_HUMAN, Q9H116
    Function: Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus:
    5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression
    Induction: By GDNF

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0043565sequence-specific DNA binding IDA16049025
    GO:0046872metal ion binding IEA--
         
    GZF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GZF1:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GZF1 
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    SwitchGear 3'UTR luciferase reporter plasmidGZF1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GZF1

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA16049025

    GZF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GZF1

    Search CenterWatch for drugs/clinical trials and news about GZF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GZF1 gene: 
    NM_022482.3  

    Unigene Cluster for GZF1:

    GDNF-inducible zinc finger protein 1
    Hs.709462  [show with all ESTs]
    Unigene Representative Sequence: NM_022482
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338121(uc010gdb.3 uc002wsy.3 uc010zsq.2 uc010zsr.2 uc002wsz.3)
    ENST00000424216 ENST00000461789 ENST00000477239 ENST00000377051 ENST00000544236
    ENST00000542987
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate GZF1 (see all 35):
    hsa-miR-3607-3p hsa-miR-1197 hsa-miR-548k hsa-miR-513a-5p hsa-miR-30d hsa-miR-30a hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidGZF1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB100265.1 AK025447.1 AK056159.1 AK056477.1 AK289814.1 AK293942.1 AK295362.1 AK314599.1 
    BC016049.1 BC125188.1 BC154409.1 

    4 DOTS entries:

    DT.455623  DT.97818521  DT.120818004  DT.120817999 

    24/87 AceView cDNA sequences (see all 87):

    F12168 AA062926 AV686075 NM_022482 AL046380 CK430798 BQ003583 AL046381 
    AA417012 AW086480 BQ003210 BI918257 AA701588 AB100265 AI680505 BU187509 
    BQ003649 T65259 AW151289 BM721085 BG718371 BM546727 BM670400 BI906184 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GZF1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:                    -     -     -     -     -     -           -                                                   
    SP2:                                                              -                                                   
    SP3:                    -     -     -     -     -     -     -     -                                                   
    SP4:                                                              -                 -                                 
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for GZF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GZF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCACACCT
    GZF1 Expression
    About this image


    See GZF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GZF1

    SOURCE GeneReport for Unigene cluster: Hs.709462

    UniProtKB/Swiss-Prot: GZF1_HUMAN, Q9H116
    Tissue specificity: Expressed in adult brain, heart, skeletal muscle, kidney and liver. Also detected in fetal
    brain and kidney, and at lower levels in fetal lung and liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GZF1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gzf11 , 5 GDNF-inducible zinc finger protein 11, 5 81.78(n)1
    82.58(a)1
      2 (73.53 cM)5
    745331  NM_028986.31  NP_083262.11 
     1486810235 
    chicken
    (Gallus gallus)
    Aves GZF11 GDNF-inducible zinc finger protein 1 74.24(n)
    77.98(a)
      421232  XM_001232813.2  XP_001232814.2 
    lizard
    (Anolis carolinensis)
    Reptilia GZF16
    Uncharacterized protein
    35(a)
    1 ↔ 1
    1(129714883-129754222)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.335852 Xenopus laevis transcribed sequence with moderate similarity more 77.7(n)    BX850650.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005378121 GDNF-inducible zinc finger protein 1-like 59.77(n)
    55.35(a)
      100537812  XM_003200754.1  XP_003200802.1 


    ENSEMBL Gene Tree for GZF1 (if available)
    TreeFam Gene Tree for GZF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GZF1 gene
    18/291 SIMAP similar genes for GZF1 using alignment to 4 protein entries:     GZF1_HUMAN (see all proteins) (see all similar genes):
    ZSCAN9    kr-znf3    ZNF    ZIK1    ZNF146    ZNF732
    ZNF78L1    ZFS-4    ZNF473    ZNF485    ZNF720    ZNF79
    ZNF808    ZNF852    DKFZp666C237    ZNF22    ZNF600    ZNF768

    GZF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/288 SNPs in GZF1 are shown (see all 288)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0647184
    ----see VAR_0647182 A V mis40--------
    rs1884319401,2
    --23343357(+) TGCCAA/GTGAGA 1 -- us2k10--------
    rs1503432571,2
    --23343378(+) ACGCAC/GCTGTC 1 -- us2k10--------
    rs1116676601,2
    C,F--23343411(+) GCCACC/TTCCAG 1 -- us2k12Minor allele frequency- T:0.08CSA WA 120
    rs48151981,2
    C,F,A,H--23343491(+) AGGTCC/TCCTCG 1 -- us2k116Minor allele frequency- T:0.27NS EA NA WA CSA 787
    rs1928538431,2
    C--23343504(+) GGCCCC/TGTTGG 1 -- us2k10--------
    rs1139111581,2
    C,F--23343722(+) TACAGG/CGGAAC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1491082041,2
    --23343753(+) CATGTG/TTGAGG 1 -- us2k10--------
    rs60830881,2
    C,F,A,H--23343793(+) GATGAG/TACTGG 1 -- us2k112Minor allele frequency- T:0.27NS EA NA CSA WA 786
    rs1449154761,2
    --23344036(+) GTGACG/TGTATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GZF1 (23342787 - 23353700 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GZF1: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613842    OMIM disorders: --

    2 diseases for GZF1:    About MalaCards
    membranous glomerulonephritis    glomerulonephritis


    GZF1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GZF1

    Export disorders for GZF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GZF1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with GZF1)
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    world of online information

    1. GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region. (PubMed id 16049025)1, 2, 3, 9 Morinaga T....Takahashi M. (2005)
    2. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. (PubMed id 14522971)1, 2, 3 Fukuda N.... Takahashi M. (2003)
    3. Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation. (PubMed id 17674968)1, 2, 9 Dambara A....Takahashi M. (2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
    7. Analysis of glial cell line-derived neurotrophic fact or-inducible zinc finger protein 1 expression in human diseased kidney. (PubMed id 21292309)1 Saito S....Takahashi M. (2011)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64412 HGNC: 15808 AceView: ZNF336 Ensembl:ENSG00000125812 euGenes: HUgn64412
    ECgene: GZF1 H-InvDB: GZF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GZF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GZF1 gene:
    Search GeneIP for patents involving GZF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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