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GYPE Gene

protein-coding   GIFtS: 46
GCID: GC04M144792

Glycophorin E (MNS Blood Group)

(Previous name: glycophorin E)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycophorin E (MNS Blood Group)1 2
GPE2 3 5
Glycophorin E1
MNS2
MiIX2
glycophorin-E2

External Ids:    HGNC: 47051   Entrez Gene: 29962   Ensembl: ENSG000001974657   OMIM: 1385905   UniProtKB: P154213   

Export aliases for GYPE gene to outside databases

Previous GC identifers: GC04M145588 GC04M145167 GC04M145369 GC04M145149 GC04M145011 GC04M140521


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GYPE Gene:
The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene
family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE
are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB
gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been
described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GYPE Gene:
GYPE (glycophorin E (MNS blood group)) is a protein-coding gene. Diseases associated with GYPE include congenital dyserythropoietic anemia type i, and congenital dyserythropoietic anemia. An important paralog of this gene is GYPB.

UniProtKB/Swiss-Prot: GLPE_HUMAN, P15421
Function: This protein is a minor sialoglycoprotein in human erythrocyte membranes

Gene Wiki entry for GYPE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the GYPE gene promoter:
         HTF   FOXD3   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Nkx5-1   FOXL1   CREB   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGYPE promoter sequence
   Search Chromatin IP Primers for GYPE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GYPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.1   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31.21

GYPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GYPE gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M144792:  view genomic region     (about GC identifiers)

Start:
144,792,019 bp from pter      End:
144,826,716 bp from pter
Size:
34,698 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GLPE_HUMAN, P15421 (See protein sequence)
Recommended Name: Glycophorin-E precursor  
Size: 78 amino acids; 8463 Da
Secondary accessions: D3DNZ5

Explore the universe of human proteins at neXtProt for GYPE: NX_P15421

Post-translational modifications: 

  • The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues (By similarity)1
  • Modification sites at neXtProt
  • REFSEQ proteins (2 alternative transcripts): 
    NP_002093.2  NP_941391.2  

    ENSEMBL proteins: 
     ENSP00000351430   ENSP00000426746   ENSP00000400698  

    GYPE Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for GYPE
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    Novus Biologicals GYPE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GYPE

    GYPE Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for GYPE
    Search for Antibodies for GYPE at Abcam
    Cloud-Clone Corp. Antibodies for GYPE
    Search ThermoFisher Antibodies for GYPE
    Search LSBio for Antibodies for GYPE

    GYPE Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for GYPE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GYPE
    Cloud-Clone Corp. CLIAs for GYPE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bloodgroup: Blood group antigens

    1 InterPro protein domain:
     IPR001195 Glycophorin

    Graphical View of Domain Structure for InterPro Entry P15421

    ProtoNet protein and cluster: P15421

    1 Blocks protein domain: IPB001195 Glycophorin A and B

    UniProtKB/Swiss-Prot: GLPE_HUMAN, P15421
    Similarity: Belongs to the glycophorin-A family


    GYPE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLPE_HUMAN, P15421
    Function: This protein is a minor sialoglycoprotein in human erythrocyte membranes

         Genatlas biochemistry entry for GYPE:
    glycophorin E

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GYPE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GYPE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GYPE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GYPE

    miRNA
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    Block miRNA regulation of human, mouse, rat GYPE using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GYPE
    SwitchGear 3'UTR luciferase reporter plasmidGYPE 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GYPE
    Predesigned siRNA for gene silencing in human, mouse, rat GYPE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GYPE

    Clone
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    OriGene clones in human, mouse for GYPE (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GYPE (NM_198682)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GYPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GYPE

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GYPE
    Browse ESI BIO Cell Lines and PureStem Progenitors for GYPE 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GYPE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLPE_HUMAN, P15421: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    extracellular2
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS2295603
    GO:0005887integral component of plasma membrane TAS7622054
    GO:0016021integral component of membrane ----

    GYPE for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GYPE
    Interactions:

        Search GeneGlobe Interaction Network for GYPE

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GYPE (GLPE)

    Selected Novoseek inferred chemical compound relationships for GYPE gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1,2-dimyristoylamido-1,2-deoxyphosphatidylcholine 86.9 11 2162203 (5), 2354176 (1)
    sialic acid 77.6 32 9584138 (3), 8595264 (2), 2176879 (2), 1936191 (2) (see all 18)
    dimyristoylphosphatidylcholine 65.8 16 2162203 (4), 1607359 (2), 1632777 (1), 1645183 (1) (see all 6)
    23-diphosphoglycerate 52.8 2 7833349 (1), 2158999 (1)
    galactose 43.5 3 9920164 (1), 12218291 (1), 9501410 (1)
    periodate 43.2 1 2176879 (1)
    phospholipid 34.4 5 8423219 (1), 8130343 (1), 8038182 (1), 2173910 (1) (see all 5)
    dopc 31.9 1 1730024 (1)
    dppc 27.5 2 1607359 (1), 1730024 (1)
    lipid 27 21 1607359 (3), 7607245 (2), 2162203 (2), 1575520 (2) (see all 10)



    GYPE for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GYPE gene (2 alternative transcripts): 
    NM_002102.3  NM_198682.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358615(uc003ijj.3) ENST00000506264 ENST00000437468(uc003ijk.4)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat GYPE using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GYPE
    SwitchGear 3'UTR luciferase reporter plasmidGYPE 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GYPE
    Predesigned siRNA for gene silencing in human, mouse, rat GYPE
    Clone
    Products:
         
    OriGene clones in human, mouse for GYPE (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GYPE (NM_198682)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GYPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GYPE
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GYPE
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat GYPE
      QuantiTect SYBR Green Assays in human, mouse, rat GYPE
      QuantiFast Probe-based Assays in human, mouse, rat GYPE

    Selected AceView cDNA sequences (see all 88):

    CR617175 AA262967 CR602358 AI288181 R93593 N55369 BC017864 H69716 
    H60100 NM_198682 BX427620 H79452 BV204894 H90924 BU665206 AY509882 
    BV200092 N59558 BX325241 AI240545 BI768253 BM978065 BC069310 BG944586 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GYPE expression in normal human tissues (normalized intensities)      GYPE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GYPE Expression
    About this image


    GYPE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     NULL (Uncategorized)
             Mesoderm-like cells
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
    GYPE Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    UniProtKB/Swiss-Prot: GLPE_HUMAN, P15421
    Tissue specificity: Erythrocytes

        Custom PCR Arrays for GYPE
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for GYPE
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat GYPE
    QuantiTect SYBR Green Assays in human, mouse, rat GYPE
    QuantiFast Probe-based Assays in human, mouse, rat GYPE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GYPE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for GYPE gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia GYPE21 glycophorin-E2 99.15(n)
    98.72(a)
      738861  XM_003950413.1  XP_003950462.1 


    ENSEMBL Gene Tree for GYPE (if available)
    TreeFam Gene Tree for GYPE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GYPE gene
    GYPB2  
    11 SIMAP similar genes for GYPE using alignment to 7 protein entries:     GLPE_HUMAN (see all proteins):
    MiIX    HGpMiV    HGpMiXI    HGpMiVI    GYP(B-A-B)    GYPB
    GYPA    HGpMiX    GPSAT    GPErik    HGPMz

    GYPE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GYPE (see all 1024)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844103531,2
    --144791653(+) CAATGG/TGTAAA 1 -- int10--------
    rs716124361,2
    C,F--144791679(+) TAGGAG/TAAATT 1 -- int12Minor allele frequency- T:0.50NA 4
    rs1887572551,2
    --144791717(+) GCAAGA/TCTGAA 1 -- int10--------
    rs1450188001,2
    --144791741(+) GTAATC/TAAATC 1 -- int10--------
    rs1149004861,2
    F--144791784(+) TGTCTC/TACATC 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1813130021,2
    --144791816(+) GTGGGC/TTCCCA 1 -- int10--------
    rs1388001001,2
    C--144791835(+) GGAAGC/TTCAGC 1 -- int10--------
    rs1148293351,2
    C,F--144791855(+) TTTGCA/CTGGTA 1 -- int11Minor allele frequency- C:0.02NA 120
    rs346045081,2
    C--144791870(+) CCCCC-/GCCTCG 1 -- int10--------
    rs346023641,2
    C--144791872(+) CCCGCC/TTCGGC 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for GYPE (144792019 - 144826716 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GYPE (see all 38):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv980e199CNV Deletion23128226
    dgv978e199CNV Deletion23128226
    nsv436452CNV Deletion17901297
    nsv435790CNV Deletion17901297
    dgv979e199CNV Deletion23128226
    dgv898e201CNV Deletion23290073
    esv2728476CNV Deletion23290073
    esv2728480CNV Deletion23290073
    nsv436411CNV Deletion17901297
    esv2668125CNV Deletion23128226

    Human Gene Mutation Database (HGMD): GYPE
    Locus Specific Mutation Databases (LSDB): GYPE

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GYPE
    DNA2.0 Custom Variant and Variant Library Synthesis for GYPE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138590    OMIM disorders: --

    13 diseases for GYPE:    About MalaCards
    congenital dyserythropoietic anemia type i    congenital dyserythropoietic anemia    autoimmune hemolytic anemia    sickle cell disease
    influenza    hemolytic anemia    vascular disease    malaria
    multiple myeloma    myeloma    parkinson's disease    cerebritis
    hiv-1

    1 disease from the University of Copenhagen DISEASES database for GYPE:
    Parkinson's disease

    GYPE for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for GYPE gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hemolysis 47.3 6 12225367 (1), 8276771 (1), 12181064 (1), 10627480 (1) (see all 5)
    malaria 34.6 2 12949139 (1), 18063920 (1)
    influenza 27.7 6 2069581 (2), 9166405 (1), 10953546 (1), 8499461 (1)
    erythroleukemia 25.5 2 16126901 (1), 8690723 (1)
    somatic mutations 13.2 1 7921055 (1)
    cancer 5.14 1 7653152 (1)
    hematoma 0 2 10916932 (2)
    bleeding 0 9 1920929 (6), 17699396 (1)
    sickle cell disease 0 2 8423219 (1), 8977264 (1)
    vascular diseases 0 2 1312416 (1), 11188894 (1)


    Export disorders for GYPE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GYPE gene, integrated from 10 sources (see all 166):
    (articles sorted by number of sources associating them with GYPE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression. (PubMed id 2390989)1, 2, 9 Vignal A.... Cartron J.-P. (Eur. J. Biochem. 1990)
    2. Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction. (PubMed id 2295603)1, 2, 9 Kudo S. and Fukuda M. (J. Biol. Chem. 1990)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals. (PubMed id 7798177)1, 2 Kudo S.... Fukuda M. (J. Biochem. 1994)
    5. Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E. (PubMed id 2249783)1, 2 Vignal A.... Cartron J.-P. (Gene 1990)
    6. Contribution of gene conversion to the retention of the sequence for M blood group type determinant in glycophorin E gene. (PubMed id 7521873)1, 9 Kudo S. and Fukuda M. (J. Biol. Chem. 1994)
    7. Human erythrocyte glycophorins: protein and gene structure analyses. (PubMed id 1591491)1, 9 Cartron J.P. and Rahuel C. (Transfus Med Rev 1992)
    8. Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites. (PubMed id 12949139)1, 9 Wang H.Y.... Wu C.I. (Mol. Biol. Evol. 2003)
    9. Molecular analysis of human glycophorin MiIX gene shows a silent segment transfer and untemplated mutation resulting from gene conversion via sequence repeats. (PubMed id 1421409)1, 9 Huang C.H.... Blumenfeld O.O. (Blood 1992)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2996 HGNC: 4705 AceView: GYPE Ensembl:ENSG00000197465 euGenes: HUgn2996
    ECgene: GYPE H-InvDB: GYPE

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GYPE Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=mns

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GYPE gene:
    Search GeneIP for patents involving GYPE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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