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Aliases for GYPE Gene

Aliases for GYPE Gene

  • Glycophorin E (MNS Blood Group) 2 3 5
  • GPE 3 4
  • Glycophorin E 2
  • MiIX 3
  • MNS 3

External Ids for GYPE Gene

Previous GeneCards Identifiers for GYPE Gene

  • GC04M145588
  • GC04M145167
  • GC04M145369
  • GC04M145149
  • GC04M145011
  • GC04M144792
  • GC04M140521

Summaries for GYPE Gene

Entrez Gene Summary for GYPE Gene

  • The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GYPE Gene

GYPE (Glycophorin E (MNS Blood Group)) is a Protein Coding gene. Diseases associated with GYPE include Hemidystonia and Multifocal Dystonia. An important paralog of this gene is GYPB.

UniProtKB/Swiss-Prot for GYPE Gene

  • This protein is a minor sialoglycoprotein in human erythrocyte membranes.

Gene Wiki entry for GYPE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GYPE Gene

Genomics for GYPE Gene

Regulatory Elements for GYPE Gene

Enhancers for GYPE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GYPE on UCSC Golden Path with GeneCards custom track

Promoters for GYPE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GYPE on UCSC Golden Path with GeneCards custom track

Genomic Location for GYPE Gene

143,870,866 bp from pter
143,905,563 bp from pter
34,698 bases
Minus strand

Genomic View for GYPE Gene

Genes around GYPE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GYPE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GYPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GYPE Gene

Proteins for GYPE Gene

  • Protein details for GYPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DNZ5

    Protein attributes for GYPE Gene

    78 amino acids
    Molecular mass:
    8463 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GYPE Gene

Proteomics data for GYPE Gene at MOPED

Post-translational modifications for GYPE Gene

  • The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.

Other Protein References for GYPE Gene

No data available for DME Specific Peptides for GYPE Gene

Domains & Families for GYPE Gene

Gene Families for GYPE Gene

Protein Domains for GYPE Gene


Suggested Antigen Peptide Sequences for GYPE Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycophorin-A family.
  • Belongs to the glycophorin-A family.
genes like me logo Genes that share domains with GYPE: view

Function for GYPE Gene

Molecular function for GYPE Gene

GENATLAS Biochemistry:
glycophorin E
UniProtKB/Swiss-Prot Function:
This protein is a minor sialoglycoprotein in human erythrocyte membranes.
genes like me logo Genes that share phenotypes with GYPE: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GYPE Gene

Localization for GYPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for GYPE Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for GYPE Gene COMPARTMENTS Subcellular localization image for GYPE gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 2
nucleus 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GYPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 2295603
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GYPE: view

Pathways & Interactions for GYPE Gene

SuperPathways for GYPE Gene

No Data Available

Interacting Proteins for GYPE Gene

Gene Ontology (GO) - Biological Process for GYPE Gene


No data available for Pathways by source and SIGNOR curated interactions for GYPE Gene

Drugs & Compounds for GYPE Gene

(11) Drugs for GYPE Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(21) Additional Compounds for GYPE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GYPE: view

Transcripts for GYPE Gene

mRNA/cDNA for GYPE Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(88) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GYPE Gene

Glycophorin E (MNS blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GYPE Gene

No ASD Table

Relevant External Links for GYPE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GYPE Gene

mRNA expression in normal human tissues for GYPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GYPE Gene

This gene is overexpressed in Whole Blood (x5.1) and Spleen (x4.1).

SOURCE GeneReport for Unigene cluster for GYPE Gene Hs.728753

mRNA Expression by UniProt/SwissProt for GYPE Gene

Tissue specificity: Erythrocytes.
genes like me logo Genes that share expression patterns with GYPE: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GYPE Gene

Orthologs for GYPE Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GYPE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GYPE2 35
  • 99.15 (n)
  • 98.72 (a)
  • 75 (a)
Species with no ortholog for GYPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GYPE Gene

Gene Tree for GYPE (if available)
Gene Tree for GYPE (if available)

Paralogs for GYPE Gene

Paralogs for GYPE Gene

genes like me logo Genes that share paralogs with GYPE: view

Variants for GYPE Gene

Sequence variations from dbSNP and Humsavar for GYPE Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_053111 -
VAR_062006 -
rs1054154 -- 143,889,523(-) TAAAG(C/T)TTAAA intron-variant
rs1054159 -- 143,889,072(-) CGCCA(G/T)TCTGA intron-variant
rs1058984 -- 143,903,233(+) TTGTT(G/T)TTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GYPE Gene

Variant ID Type Subtype PubMed ID
dgv1683e1 CNV Complex 17122850
dgv1684e1 CNV Complex 17122850
nsv428452 CNV Loss 18775914
dgv1685e1 CNV Complex 17122850
dgv1686e1 CNV Complex 17122850
dgv4n29 CNV Loss 16826518
esv2728476 CNV Deletion 23290073
dgv978e199 CNV Deletion 23128226
dgv898e201 CNV Deletion 23290073
dgv979e199 CNV Deletion 23128226
nsv436452 CNV Deletion 17901297
esv2752026 CNV Gain 17911159
dgv189e55 CNV Gain 17911159
nsv880178 CNV Gain 21882294
nsv528303 CNV Gain 19592680
dgv667n27 CNV Gain 19166990
dgv5767n71 CNV Gain 21882294
nsv517006 CNV Gain+Loss 19592680
nsv436078 CNV Insertion 17901297
nsv461664 CNV Gain 19166990
nsv461665 CNV Loss 19166990
nsv10584 CNV Gain+Loss 18304495
nsv880181 CNV Gain+Loss 21882294
nsv880182 CNV Gain 21882294
dgv980e199 CNV Deletion 23128226
nsv880185 CNV Loss 21882294
dgv5768n71 CNV Gain 21882294
dgv5769n71 CNV Gain 21882294
nsv435790 CNV Deletion 17901297
dgv1687e1 CNV Complex 17122850
esv2752030 CNV Gain 17911159
dgv1688e1 CNV Complex 17122850
nsv880191 CNV Gain+Loss 21882294
nsv436411 CNV Deletion 17901297
esv2728480 CNV Deletion 23290073
dgv5770n71 CNV Gain 21882294
esv2668125 CNV Deletion 23128226
dgv5771n71 CNV Gain 21882294

Variation tolerance for GYPE Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GYPE Gene

Human Gene Mutation Database (HGMD)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GYPE Gene

Disorders for GYPE Gene

MalaCards: The human disease database

(2) MalaCards diseases for GYPE Gene - From: DISEASES

Disorder Aliases PubMed IDs
multifocal dystonia
- elite association - COSMIC cancer census association via MalaCards
Search GYPE in MalaCards View complete list of genes associated with diseases

Relevant External Links for GYPE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GYPE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GYPE Gene

Publications for GYPE Gene

  1. A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression. (PMID: 2390989) Vignal A. … Cartron J.-P. (Eur. J. Biochem. 1990) 3 4 23 67
  2. Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites. (PMID: 12949139) Wang H.Y. … Wu C.I. (Mol. Biol. Evol. 2003) 3 23
  3. Contribution of gene conversion to the retention of the sequence for M blood group type determinant in glycophorin E gene. (PMID: 7521873) Kudo S. … Fukuda M. (J. Biol. Chem. 1994) 3 23
  4. Molecular analysis of human glycophorin MiIX gene shows a silent segment transfer and untemplated mutation resulting from gene conversion via sequence repeats. (PMID: 1421409) Huang C.H. … Blumenfeld O.O. (Blood 1992) 3 23
  5. Human erythrocyte glycophorins: protein and gene structure analyses. (PMID: 1591491) Cartron J.P. … Rahuel C. (Transfus Med Rev 1992) 3 23

Products for GYPE Gene

Sources for GYPE Gene