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Aliases for GYPC Gene

Aliases for GYPC Gene

  • Glycophorin C (Gerbich Blood Group) 2 3 5
  • Sialoglycoprotein D 3 4
  • Glycoprotein Beta 3 4
  • Glycoconnectin 3 4
  • Glycophorin-D 3 4
  • PAS-2 3 4
  • GPD 3 4
  • GPC 3 4
  • CD236 Antigen 4
  • CD236R 3
  • CD236 3
  • GYPD 3
  • GLPC 4
  • GE 3

External Ids for GYPC Gene

Previous GeneCards Identifiers for GYPC Gene

  • GC02P124707
  • GC02P125340
  • GC02P127318
  • GC02P127506
  • GC02P127129
  • GC02P127413
  • GC02P119723

Summaries for GYPC Gene

Entrez Gene Summary for GYPC Gene

  • Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

GeneCards Summary for GYPC Gene

GYPC (Glycophorin C (Gerbich Blood Group)) is a Protein Coding gene. Diseases associated with GYPC include malaria and marek disease. Among its related pathways are Malaria.

UniProtKB/Swiss-Prot for GYPC Gene

  • This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GYPC Gene

Genomics for GYPC Gene

Regulatory Elements for GYPC Gene

Promoters for GYPC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GYPC on UCSC Golden Path with GeneCards custom track

Genomic Location for GYPC Gene

Chromosome:
2
Start:
126,655,933 bp from pter
End:
126,696,675 bp from pter
Size:
40,743 bases
Orientation:
Plus strand

Genomic View for GYPC Gene

Genes around GYPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GYPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GYPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GYPC Gene

Proteins for GYPC Gene

  • Protein details for GYPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04921-GLPC_HUMAN
    Recommended name:
    Glycophorin-C
    Protein Accession:
    P04921
    Secondary Accessions:
    • B2R522
    • Q53SV9
    • Q92642

    Protein attributes for GYPC Gene

    Size:
    128 amino acids
    Molecular mass:
    13811 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA32093.1; Type=Frameshift; Positions=35; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GYPC Gene

    Alternative splice isoforms for GYPC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GYPC Gene

Proteomics data for GYPC Gene at MOPED

Post-translational modifications for GYPC Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Ser 3, Thr 4, Ser 6, Asn 8, Ser 9, Thr 10, Ser 15, Ser 24, Ser 26, Thr 27, Thr 28, Thr 31, Thr 32, Thr 33, and Ser 42
  • Modification sites at PhosphoSitePlus

Other Protein References for GYPC Gene

No data available for DME Specific Peptides for GYPC Gene

Domains & Families for GYPC Gene

Gene Families for GYPC Gene

Protein Domains for GYPC Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P04921

UniProtKB/Swiss-Prot:

GLPC_HUMAN :
  • Belongs to the glycophorin-C family.
Family:
  • Belongs to the glycophorin-C family.
genes like me logo Genes that share domains with GYPC: view

Function for GYPC Gene

Molecular function for GYPC Gene

GENATLAS Biochemistry:
glycophorin C and D (Gerbich blood group),plasmodium falciparum receptor
UniProtKB/Swiss-Prot Function:
This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
genes like me logo Genes that share phenotypes with GYPC: view

Human Phenotype Ontology for GYPC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for GYPC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GYPC Gene

Localization for GYPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for GYPC Gene

Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GYPC Gene COMPARTMENTS Subcellular localization image for GYPC gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
nucleus 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GYPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 2416746
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GYPC: view

Pathways & Interactions for GYPC Gene

SuperPathways for GYPC Gene

Superpath Contained pathways
1 Malaria
genes like me logo Genes that share pathways with GYPC: view

Pathways by source for GYPC Gene

1 KEGG pathway for GYPC Gene

Gene Ontology (GO) - Biological Process for GYPC Gene

None

No data available for SIGNOR curated interactions for GYPC Gene

Drugs & Compounds for GYPC Gene

(8) Drugs for GYPC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for GYPC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GYPC: view

Transcripts for GYPC Gene

Unigene Clusters for GYPC Gene

Glycophorin C (Gerbich blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GYPC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for GYPC Gene

GeneLoc Exon Structure for
GYPC
ECgene alternative splicing isoforms for
GYPC

Expression for GYPC Gene

mRNA expression in normal human tissues for GYPC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GYPC Gene

This gene is overexpressed in Whole Blood (x19.9).

Protein differential expression in normal tissues from HIPED for GYPC Gene

This gene is overexpressed in Prostate (9.2), Spleen (8.0), Urinary Bladder (7.3), and Neutrophil (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GYPC Gene



SOURCE GeneReport for Unigene cluster for GYPC Gene Hs.59138

mRNA Expression by UniProt/SwissProt for GYPC Gene

P04921-GLPC_HUMAN
Tissue specificity: Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.
genes like me logo Genes that share expression patterns with GYPC: view

Protein tissue co-expression partners for GYPC Gene

Primer Products

In Situ Assay Products

Orthologs for GYPC Gene

This gene was present in the common ancestor of chordates.

Orthologs for GYPC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GYPC 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPC 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GYPC 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gypc 16
Gypc 36
  • 74 (a)
OneToOne
Gypc 35
  • 79.93 (n)
  • 76.34 (a)
oppossum
(Monodelphis domestica)
Mammalia GYPC 36
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GYPC 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gypc 35
  • 79.21 (n)
  • 75.27 (a)
chicken
(Gallus gallus)
Aves GYPC 35
  • 67.44 (n)
  • 68.6 (a)
GYPC 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GYPC 36
  • 86 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2910 35
zebrafish
(Danio rerio)
Actinopterygii gypc 36
  • 58 (a)
OneToOne
Species with no ortholog for GYPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GYPC Gene

ENSEMBL:
Gene Tree for GYPC (if available)
TreeFam:
Gene Tree for GYPC (if available)

Paralogs for GYPC Gene

(5) SIMAP similar genes for GYPC Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GYPC: view

No data available for Paralogs for GYPC Gene

Variants for GYPC Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GYPC Gene

P04921-GLPC_HUMAN
Deletion of exon 3 in GYPC results in resistance to Plasmodium falciparum invasion and protection against severe malaria [MIM:611162].

Sequence variations from dbSNP and Humsavar for GYPC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_003193 -
VAR_003194 -
VAR_003195 -
rs28370000 - 126,696,125(+) GCAGA(A/G)AGGAG reference, missense
rs6568 -- 126,696,654(+) AAATT(G/T)GAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GYPC Gene

Variant ID Type Subtype PubMed ID
dgv4294n71 CNV Loss 21882294
dgv4295n71 CNV Loss 21882294
nsv875005 CNV Loss 21882294
nsv875006 CNV Loss 21882294
nsv875007 CNV Loss 21882294
nsv875008 CNV Gain 21882294
esv2429496 CNV Deletion 19546169
dgv4296n71 CNV Loss 21882294
esv2672764 CNV Deletion 23128226
esv2720722 CNV Deletion 23290073

Variation tolerance for GYPC Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GYPC Gene

HapMap Linkage Disequilibrium report
GYPC
Human Gene Mutation Database (HGMD)
GYPC
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

Disorders for GYPC Gene

MalaCards: The human disease database

(7) MalaCards diseases for GYPC Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malaria
  • malaria, severe
marek disease
  • fowl paralyses
laryngotracheitis
vulvitis
vulvar disease
  • vulvar diseases
- elite association - COSMIC cancer census association via MalaCards
Search GYPC in MalaCards View complete list of genes associated with diseases

Relevant External Links for GYPC

Genetic Association Database (GAD)
GYPC
Human Genome Epidemiology (HuGE) Navigator
GYPC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GYPC
genes like me logo Genes that share disorders with GYPC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GYPC Gene

Publications for GYPC Gene

  1. A point mutation in the GYPC gene results in the expression of the blood group Ana antigen on glycophorin D but not on glycophorin C: further evidence that glycophorin D is a product of the GYPC gene. (PMID: 8219208) Daniels G. … Cedergren B. (Blood 1993) 3 4 23 67
  2. Molecular evolution of GYPC: evidence for recent structural innovation and positive selection in humans. (PMID: 19679754) Wilder J.A. … Gansner M.E. (Mol. Biol. Evol. 2009) 3 23
  3. Phosphatidylinositol-4,5-biphosphate (PIP2) differentially regulates the interaction of human erythrocyte protein 4.1 (4.1R) with membrane proteins. (PMID: 16669616) An X. … Mohandas N. (Biochemistry 2006) 3 23
  4. Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. (PMID: 12469115) Maier A.G. … Cowman A.F. (Nat. Med. 2003) 3 23
  5. The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis. (PMID: 9305870) Marfatia S.M. … Chishti A.H. (J. Biol. Chem. 1997) 3 23

Products for GYPC Gene

Sources for GYPC Gene

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