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Aliases for GYPB Gene

Aliases for GYPB Gene

  • Glycophorin B (MNS Blood Group) 2 3
  • SS-Active Sialoglycoprotein 3 4
  • Sialoglycoprotein Delta 3 4
  • PAS-3 3 4
  • MNS 3 6
  • GPB 3 4
  • SS 3 6
  • Glycophorin B (Includes Ss Blood Group) 2
  • Glycophorin B (Ss Blood Group) 2
  • Ss Blood Group 3
  • CD235b Antigen 4
  • Glycophorin-B 3
  • CD235b 3

External Ids for GYPB Gene

Previous HGNC Symbols for GYPB Gene

  • MNS

Previous GeneCards Identifiers for GYPB Gene

  • GC04M145713
  • GC04M145292
  • GC04M145495
  • GC04M145496
  • GC04M145274
  • GC04M145136
  • GC04M144918

Summaries for GYPB Gene

Entrez Gene Summary for GYPB Gene

  • Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for GYPB Gene

GYPB (Glycophorin B (MNS Blood Group)) is a Protein Coding gene. Diseases associated with GYPB include malaria. Among its related pathways are Malaria. An important paralog of this gene is GYPE.

UniProtKB/Swiss-Prot for GYPB Gene

  • This protein is a minor sialoglycoprotein in erythrocyte membranes

Gene Wiki entry for GYPB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GYPB Gene

Genomics for GYPB Gene

Regulatory Elements for GYPB Gene

Genomic Location for GYPB Gene

143,996,104 bp from pter
144,019,345 bp from pter
23,242 bases
Minus strand

Genomic View for GYPB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GYPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GYPB Gene

Proteins for GYPB Gene

  • Protein details for GYPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B8Q174
    • E2QBW7
    • Q0VAF4
    • Q58HE9
    • Q58HF0
    • Q58HF1
    • Q9UCH7

    Protein attributes for GYPB Gene

    91 amino acids
    Molecular mass:
    9782 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GYPB Gene


neXtProt entry for GYPB Gene

Proteomics data for GYPB Gene at MOPED

Post-translational modifications for GYPB Gene

  • The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.
  • Glycosylation at Thr36, Ser38, and Thr44
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GYPB Gene

Domains for GYPB Gene

Gene Families for GYPB Gene

Protein Domains for GYPB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycophorin-A family.
  • Belongs to the glycophorin-A family.
genes like me logo Genes that share domains with GYPB: view

Function for GYPB Gene

Molecular function for GYPB Gene

GENATLAS Biochemistry:
glycophorin B (Ss specifity)
UniProtKB/Swiss-Prot Function:
This protein is a minor sialoglycoprotein in erythrocyte membranes

Gene Ontology (GO) - Molecular Function for GYPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GYPB: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GYPB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GYPB Gene

Localization for GYPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for GYPB Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for GYPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 2295603
GO:0005887 integral component of plasma membrane TAS 7622054
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GYPB: view

No data available for Subcellular locations from COMPARTMENTS for GYPB Gene

Pathways for GYPB Gene

SuperPathways for GYPB Gene

Superpath Contained pathways
1 Malaria
genes like me logo Genes that share pathways with GYPB: view

Pathways by source for GYPB Gene

1 KEGG pathway for GYPB Gene

Interacting Proteins for GYPB Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000427690 P06028-GLPB_HUMAN for GYPB Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for GYPB Gene


Drugs for GYPB Gene

(7) HMDB Compounds for GYPB Gene

Compound Synonyms Cas Number PubMed IDs
1D-Myo-inositol 1,4-bisphosphate
  • 1D-Myo-inositol 1,4-bisphosphate
  • (+)-mannose
  • (2R,3R,4S,5R,6R)-2-[(2R)-2,3-dihydroxypropoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  • 1,2,3-Trihydroxypropane

(10) Novoseek inferred chemical compound relationships for GYPB Gene

Compound -log(P) Hits PubMed IDs
polylactosamine 56.6 1
sialic acid 56 4
porphobilinogen 55.3 3
5-aminolevulinic acid 25 2
glycogen 16.8 4
genes like me logo Genes that share compounds with GYPB: view

Transcripts for GYPB Gene

Unigene Clusters for GYPB Gene

Glycophorin B (MNS blood group):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GYPB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GYPB Gene

No ASD Table

Relevant External Links for GYPB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GYPB Gene

mRNA expression in normal human tissues for GYPB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GYPB Gene

This gene is overexpressed in Whole Blood (46.6).

SOURCE GeneReport for Unigene cluster for GYPB Gene Hs.654368

genes like me logo Genes that share expressions with GYPB: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for GYPB Gene

Orthologs for GYPB Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GYPB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GYPE 36
  • 82 (a)
Species with no ortholog for GYPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GYPB Gene

Gene Tree for GYPB (if available)
Gene Tree for GYPB (if available)

Paralogs for GYPB Gene

Paralogs for GYPB Gene Pseudogenes for GYPB Gene

genes like me logo Genes that share paralogs with GYPB: view

Variants for GYPB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GYPB Gene

Along with GYPA, GYPB is responsible for the MNS blood group system. The molecular basis of the S/s blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 and Met-48 to S=MNS3

Sequence variations from dbSNP and Humsavar for GYPB Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs13040 -- 143,996,259(-) AACCG(G/T)CTGCA utr-variant-3-prime, reference, missense
rs1053396 -- 143,996,239(-) CTCTT(C/G)TTTAT utr-variant-3-prime, missense, reference
rs1132783 - 143,997,559(-) TTACA(C/G)TATTC missense, reference, intron-variant
rs1444985 -- 144,006,014(+) TAATG(A/T)TTAAG intron-variant
rs1473055 -- 143,997,714(+) TCAGC(A/G)TAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GYPB Gene

Variant ID Type Subtype PubMed ID
dgv1684e1 CNV Complex 17122850
nsv428452 CNV Loss 18775914
dgv1686e1 CNV Complex 17122850
esv2728476 CNV Deletion 23290073
dgv978e199 CNV Deletion 23128226
nsv436452 CNV Deletion 17901297
esv2752026 CNV Gain 17911159
dgv189e55 CNV Gain 17911159
dgv667n27 CNV Gain 19166990
dgv5767n71 CNV Gain 21882294
nsv517006 CNV Gain+Loss 19592680
nsv436078 CNV Insertion 17901297
nsv461664 CNV Gain 19166990
nsv461665 CNV Loss 19166990
nsv10584 CNV Gain+Loss 18304495
nsv880182 CNV Gain 21882294
dgv5769n71 CNV Gain 21882294
dgv1687e1 CNV Complex 17122850
esv2752030 CNV Gain 17911159
dgv1688e1 CNV Complex 17122850
nsv880191 CNV Gain+Loss 21882294
nsv436411 CNV Deletion 17901297
esv2728480 CNV Deletion 23290073
dgv5770n71 CNV Gain 21882294
esv2668125 CNV Deletion 23128226
dgv5771n71 CNV Gain 21882294
nsv880195 CNV Gain 21882294
nsv880196 CNV Loss 21882294
esv2421355 CNV Deletion 20811451
esv34775 CNV Loss 17911159
dgv1689e1 CNV Complex 17122850
nsv818281 CNV Loss 17921354
dgv1690e1 CNV Complex 17122850
dgv5772n71 CNV Gain 21882294
essv16952 CNV CNV 17122850
dgv5773n71 CNV Loss 21882294
nsv469732 CNV Gain 16826518
dgv5774n71 CNV Gain 21882294
dgv1691e1 CNV Complex 17122850
nsv436881 CNV Insertion 17901297
nsv435807 CNV Deletion 17901297
dgv668n27 CNV Gain 19166990
esv2662558 CNV Deletion 23128226
esv2728481 CNV Deletion 23290073
dgv1692e1 CNV Complex 17122850
dgv5775n71 CNV Gain 21882294
nsv880211 CNV Gain+Loss 21882294
esv29621 CNV Gain+Loss 19812545
nsv437438 CNV Loss 16327808
nsv822759 CNV Gain 20364138
nsv441919 CNV CNV 18776908
esv34834 CNV Gain 17911159
nsv514257 CNV Gain 21397061
nsv818282 CNV Gain 17921354
dgv669n27 CNV Gain 19166990
nsv437439 CNV Loss 16327808

Relevant External Links for GYPB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group

Disorders for GYPB Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for GYPB Gene in MalaCards »

(1) Disease for GYPB Gene

(1) OMIM Diseases for GYPB Gene (111740)

(3) Novoseek inferred disease relationships for GYPB Gene

Disease -log(P) Hits PubMed IDs
anemia dyserythropoietic congenital 76.6 3
malaria 26.5 1
influenza 0 2

Relevant External Links for GYPB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GYPB: view

No data available for UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for GYPB Gene

Publications for GYPB Gene

  1. The low-incidence MNS antigens M(v), s(D), and Mit arise from single amino acid substitutions on GPB. (PMID: 11239234) Storry J.R. … Nortman P. (Transfusion 2001) 3 4 23
  2. The genotypes of GYPA and GYPB carrying the MNSs antigens are not associated with cerebral malaria. (PMID: 17372674) Naka I. … Tokunaga K. (J. Hum. Genet. 2007) 3 23 48
  3. Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites. (PMID: 12949139) Wang H.Y. … Wu C.I. (Mol. Biol. Evol. 2003) 3 23
  4. Detailed physical mapping of the genes encoding glycophorins A, B and E, as revealed by P1 plasmids containing human genomic DNA. (PMID: 7622054) Onda M. … Fukuda M. (Gene 1995) 3 23
  5. Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification. (PMID: 2016325) Huang C.-H. … Blumenfeld O.O. (J. Biol. Chem. 1991) 3 4

Products for GYPB Gene

Sources for GYPB Gene

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