Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GYPB Gene

Aliases for GYPB Gene

  • Glycophorin B (MNS Blood Group) 2 3 5
  • SS-Active Sialoglycoprotein 3 4
  • Sialoglycoprotein Delta 3 4
  • PAS-3 3 4
  • GPB 3 4
  • Glycophorin B, Blood Group System Ss, S, Mit+ 3
  • Glycophorin B/Glycophorin A Fusion Protein 3
  • Glycophorin B (Includes Ss Blood Group) 2
  • Blood Group System MNSs, St(A) Type E 3
  • Blood Group System MNSs, St(A) Type F 3
  • Blood Group System MNSs, Mur-Like 3
  • Glycophorin B (Ss Blood Group) 2
  • Hybrid Glycophorin Kip 3
  • GYPB/GYPA Fusion 3
  • GYPB-A-B Fusion 3
  • Glycophorin Hop 3
  • Ss Blood Group 3
  • CD235b Antigen 4
  • GYPB-A Fusion 3
  • Glycophorin-B 3
  • CD235b 3
  • MNS 3
  • GYP 3
  • SS 3

External Ids for GYPB Gene

Previous HGNC Symbols for GYPB Gene

  • MNS

Previous GeneCards Identifiers for GYPB Gene

  • GC04M145713
  • GC04M145292
  • GC04M145495
  • GC04M145496
  • GC04M145274
  • GC04M145136
  • GC04M144918

Summaries for GYPB Gene

Entrez Gene Summary for GYPB Gene

  • Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for GYPB Gene

GYPB (Glycophorin B (MNS Blood Group)) is a Protein Coding gene. Diseases associated with GYPB include Malaria and Rh Deficiency Syndrome. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+.

UniProtKB/Swiss-Prot for GYPB Gene

  • This protein is a minor sialoglycoprotein in erythrocyte membranes.

Gene Wiki entry for GYPB Gene

Additional gene information for GYPB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GYPB Gene

Genomics for GYPB Gene

Regulatory Elements for GYPB Gene

Enhancers for GYPB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H144104 0.9 FANTOM5 22 -85.6 -85552 0.2 LEF1 NFRKB TAL1 CHAMP1 RELA TCF12 CC2D1A ZNF316 NCOR1 FOXK2 GYPA GYPE GYPB LOC105377460 LOC105377461
GH04H143984 0.3 FANTOM5 11.8 +34.9 34890 0.3 LOC100419356 GYPE GYPA GYPB PIR47279
GH04H143975 0.8 ENCODE 0.3 +43.7 43745 0.2 HDAC1 PKNOX1 ARNT TCF12 ATF7 ZBTB2 NCOA1 ZEB2 NFIC MTA1 LOC100419356 GYPB PIR47279
GH04H144078 0.9 ENCODE 0.2 -59.6 -59609 0.5 HDAC1 PKNOX1 ARNT CHAMP1 TCF12 ZNF766 ATF7 ZBTB2 NCOA1 ZEB2 LOC105377460 GYPB
GH04H144079 0.7 ENCODE 0.2 -59.2 -59236 0.2 LEF1 PKNOX1 ARNT CHAMP1 TCF12 ZNF766 CTBP1 MTA3 NCOR1 ATF7 LOC105377460 GYPB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GYPB on UCSC Golden Path with GeneCards custom track

Genomic Locations for GYPB Gene

Genomic Locations for GYPB Gene
24,240 bases
Minus strand

Genomic View for GYPB Gene

Genes around GYPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GYPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GYPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GYPB Gene

Proteins for GYPB Gene

  • Protein details for GYPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B8Q174
    • E2QBW7
    • Q0VAF4
    • Q58HE9
    • Q58HF0
    • Q58HF1
    • Q9UCH7

    Protein attributes for GYPB Gene

    91 amino acids
    Molecular mass:
    9782 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GYPB Gene


neXtProt entry for GYPB Gene

Post-translational modifications for GYPB Gene

  • The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.
  • Glycosylation at isoforms=36, isoforms=38, and isoforms=44
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GYPB Gene

Domains & Families for GYPB Gene

Gene Families for GYPB Gene

Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for GYPB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycophorin-A family.
  • Belongs to the glycophorin-A family.
genes like me logo Genes that share domains with GYPB: view

Function for GYPB Gene

Molecular function for GYPB Gene

GENATLAS Biochemistry:
glycophorin B (Ss specifity)
UniProtKB/Swiss-Prot Function:
This protein is a minor sialoglycoprotein in erythrocyte membranes.

Phenotypes From GWAS Catalog for GYPB Gene

Gene Ontology (GO) - Molecular Function for GYPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GYPB: view

Phenotypes for GYPB Gene

genes like me logo Genes that share phenotypes with GYPB: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GYPB Gene

Localization for GYPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for GYPB Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GYPB gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GYPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7622054
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GYPB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GYPB Gene

Pathways & Interactions for GYPB Gene

genes like me logo Genes that share pathways with GYPB: view

Pathways by source for GYPB Gene

1 KEGG pathway for GYPB Gene

Gene Ontology (GO) - Biological Process for GYPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with GYPB: view

No data available for SIGNOR curated interactions for GYPB Gene

Drugs & Compounds for GYPB Gene

(8) Drugs for GYPB Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Approved, Investigational Pharma 253
Sorbitol Approved Pharma 39
D-Myo-Inositol-1,4-Bisphosphate Experimental Pharma 0
mannose Investigational Pharma 0

(9) Additional Compounds for GYPB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (2R,3R,4S,5R,6R)-2-[(2R)-2,3-dihydroxypropoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  • 3-b-D-Galactosyl-sn-glycerol
  • 3-beta-D-Galactosyl-sn-glycerol
  • 3-beta-delta-Galactosyl-sn-glycerol
  • Azepan-2-one
  • 6-O-alpha-D-Galactosyl-D-glucitol
  • 6-O-alpha-delta-Galactosyl-delta-glucitol
genes like me logo Genes that share compounds with GYPB: view

Transcripts for GYPB Gene

Unigene Clusters for GYPB Gene

Glycophorin B (MNS blood group):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GYPB Gene

No ASD Table

Relevant External Links for GYPB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GYPB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GYPB Gene

mRNA differential expression in normal tissues according to GTEx for GYPB Gene

This gene is overexpressed in Whole Blood (x46.6).

NURSA nuclear receptor signaling pathways regulating expression of GYPB Gene:


SOURCE GeneReport for Unigene cluster for GYPB Gene:


Evidence on tissue expression from TISSUES for GYPB Gene

  • Blood(4.4)
genes like me logo Genes that share expression patterns with GYPB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GYPB Gene

Orthologs for GYPB Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GYPB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GYPE 34
  • 82 (a)
Species where no ortholog for GYPB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GYPB Gene

Gene Tree for GYPB (if available)
Gene Tree for GYPB (if available)

Paralogs for GYPB Gene

No data available for Paralogs for GYPB Gene

Variants for GYPB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GYPB Gene

Along with GYPA, GYPB is responsible for the MNS blood group system. The molecular basis of the S/s blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 and Met-48 to S=MNS3.

Sequence variations from dbSNP and Humsavar for GYPB Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000030451 -- 144,010,527(+) AGAAT(A/T)AGGGA intron-variant
rs1000100766 -- 144,015,984(+) ACTGC(C/T)TACTA intron-variant
rs1000192462 -- 144,002,129(+) ATTTT(A/G)TAAAA intron-variant
rs10002395 -- 144,011,706(+) GCTAT(G/T)GATTT intron-variant
rs1000250474 -- 144,010,691(+) GATCA(A/G)TAGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GYPB Gene

Variant ID Type Subtype PubMed ID
nsv967799 CNV duplication 23825009
nsv822759 CNV gain 20364138
nsv818282 CNV gain 17921354
nsv818281 CNV loss 17921354
nsv595612 CNV loss 21841781
nsv595609 CNV loss 21841781
nsv595607 CNV gain 21841781
nsv517006 CNV gain+loss 19592680
nsv514257 CNV gain 21397061
nsv469732 CNV gain 16826518
nsv461665 CNV loss 19166990
nsv461664 CNV gain 19166990
nsv441919 CNV gain+loss 18776908
nsv437439 CNV loss 16327808
nsv437438 CNV loss 16327808
nsv436881 CNV insertion 17901297
nsv436452 CNV deletion 17901297
nsv436411 CNV deletion 17901297
nsv436078 CNV insertion 17901297
nsv435807 CNV deletion 17901297
nsv428452 CNV loss 18775914
nsv1126044 CNV deletion 24896259
nsv10584 CNV gain+loss 18304495
nsv1030924 CNV loss 25217958
nsv1024138 CNV loss 25217958
nsv1023589 CNV gain 25217958
nsv1023490 CNV gain+loss 25217958
nsv1022823 CNV loss 25217958
nsv1020719 CNV gain 25217958
nsv1019176 CNV loss 25217958
esv3894048 CNV gain 25118596
esv3894047 CNV gain 25118596
esv3894044 CNV gain 25118596
esv3894042 CNV gain 25118596
esv3602528 CNV loss 21293372
esv3602527 CNV loss 21293372
esv3602521 CNV loss 21293372
esv3602516 CNV loss 21293372
esv34834 CNV gain 17911159
esv34775 CNV loss 17911159
esv29621 CNV gain+loss 19812545
esv2759288 CNV gain+loss 17122850
esv2752030 CNV gain 17911159
esv2752026 CNV gain 17911159
esv2728481 CNV deletion 23290073
esv2728480 CNV deletion 23290073
esv2728476 CNV deletion 23290073
esv2668125 CNV deletion 23128226
esv2662558 CNV deletion 23128226
esv2421355 CNV deletion 20811451
dgv978e199 CNV deletion 23128226
dgv9297n54 CNV gain 21841781
dgv669n27 CNV gain 19166990
dgv668n27 CNV gain 19166990
dgv667n27 CNV gain 19166990
dgv5431n100 CNV gain+loss 25217958
dgv5430n100 CNV gain 25217958
dgv5429n100 CNV loss 25217958
dgv5428n100 CNV loss 25217958
dgv5427n100 CNV loss 25217958
dgv5426n100 CNV gain 25217958
dgv5425n100 CNV loss 25217958
dgv5423n100 CNV loss 25217958
dgv5422n100 CNV loss 25217958
dgv5421n100 CNV gain 25217958
dgv5420n100 CNV loss 25217958
dgv5419n100 CNV gain 25217958
dgv5418n100 CNV gain 25217958
dgv5417n100 CNV gain 25217958
dgv5416n100 CNV loss 25217958
dgv2914n106 CNV duplication 24896259
dgv189e55 CNV gain 17911159
dgv127e203 CNV gain+loss 21179565

Variation tolerance for GYPB Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GYPB Gene

Human Gene Mutation Database (HGMD)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for GYPB Gene

MalaCards: The human disease database

(5) MalaCards diseases for GYPB Gene - From: HGMD, OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • malaria, severe
rh deficiency syndrome
  • rh-null syndrome
chronic maxillary sinusitis
  • chronic antritis
carrion's disease
  • carrion disease
hereditary spherocytosis
  • congenital spherocytic hemolytic anemia
- elite association - COSMIC cancer census association via MalaCards
Search GYPB in MalaCards View complete list of genes associated with diseases

Relevant External Links for GYPB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GYPB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GYPB Gene

Publications for GYPB Gene

  1. The genotypes of GYPA and GYPB carrying the MNSs antigens are not associated with cerebral malaria. (PMID: 17372674) Naka I … Tokunaga K (Journal of human genetics 2007) 3 22 45 60
  2. The low-incidence MNS antigens M(v), s(D), and Mit arise from single amino acid substitutions on GPB. (PMID: 11239234) Storry JR … Nortman P (Transfusion 2001) 3 4 22 60
  3. MNS blood group system: a review. (PMID: 20406014) Reid ME (Immunohematology 2009) 3 22 60
  4. Introduction of a real-time-based blood-group genotyping approach. (PMID: 18510579) Polin H … Gabriel C (Vox sanguinis 2008) 3 45 60
  5. An alloantibody to a high-prevalence MNS antigen in a person with a GP.JL/Mk phenotype. (PMID: 18284304) Ratliff J … Reid ME (Immunohematology 2007) 3 22 60

Products for GYPB Gene

  • Addgene plasmids for GYPB

Sources for GYPB Gene

Loading form....