Aliases for GYPB Gene
External Ids for GYPB Gene
Previous HGNC Symbols for GYPB Gene
Previous GeneCards Identifiers for GYPB Gene
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for GYPB Gene
GYPB (Glycophorin B (MNS Blood Group)) is a Protein Coding gene. Diseases associated with GYPB include Short Stature, Idiopathic Familial and Leri-Weill Dyschondrosteosis. Among its related pathways are Malaria. An important paralog of this gene is GYPE.
UniProtKB/Swiss-Prot for GYPB Gene
This protein is a minor sialoglycoprotein in erythrocyte membranes.