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GYPB Gene

protein-coding   GIFtS: 54
GCID: GC04M144918

Glycophorin B (MNS Blood Group)

(Previous names: glycophorin B (includes Ss blood group), glycophorin B (Ss...)
(Previous symbol: MNS)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycophorin B (MNS Blood Group)1 2     GpMiIII2
MNS1 2 5     HGpMiIII2
Sialoglycoprotein Delta2 3     HGpMiVI2
GPB2 3     HGpMiX2
PAS-32 3     Glycophorin HeP22
SS-Active Sialoglycoprotein2 3     Glycophorin MiIII2
SS2 5     Glycophorin MiVI2
Glycophorin B (Includes Ss Blood Group)1     Glycophorin MiX2
Glycophorin B (Ss Blood Group)1     glycophorin-B2
CD235b2     Ss Blood Group2
GPB.NY2     CD235b Antigen3
GYPHe.NY2     

External Ids:    HGNC: 47031   Entrez Gene: 29942   Ensembl: ENSG000002503617   OMIM: 1117405   UniProtKB: P060283   

Export aliases for GYPB gene to outside databases

Previous GC identifers: GC04M145713 GC04M145292 GC04M145495 GC04M145496 GC04M145274 GC04M145136


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GYPB Gene:
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the
antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence
homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M
or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been
identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta;
also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene
recombinations between GYPA and GYPB. (provided by RefSeq, Jul 2008)

GeneCards Summary for GYPB Gene:
GYPB (glycophorin B (MNS blood group)) is a protein-coding gene. Diseases associated with GYPB include malaria, and cerebral malaria. An important paralog of this gene is GYPE.

UniProtKB/Swiss-Prot: GLPB_HUMAN, P06028
Function: This protein is a minor sialoglycoprotein in erythrocyte membranes

Gene Wiki entry for GYPB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GYPB gene promoter:
         FOXO4   FOXD3   Nkx5-1   Roaz   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GYPB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GYPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.21   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31.21

GYPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GYPB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M144918:  view genomic region     (about GC identifiers)

Start:
144,917,257 bp from pter      End:
145,061,844 bp from pter
Size:
144,588 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GLPB_HUMAN, P06028 (See protein sequence)
Recommended Name: Glycophorin-B precursor  
Size: 91 amino acids; 9782 Da
Secondary accessions: B8Q174 E2QBW7 Q0VAF4 Q58HE9 Q58HF0 Q58HF1 Q9UCH7
Alternative splicing: 2 isoforms:  P06028-1   P06028-2   

Explore the universe of human proteins at neXtProt for GYPB: NX_P06028

Post-translational modifications: 

  • The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues1
  • Glycosylation2 at Thr36, Ser38, Thr44
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_002091.3  
    ENSEMBL proteins: 
     ENSP00000422726   ENSP00000427690   ENSP00000425244   ENSP00000423055   ENSP00000424025  
     ENSP00000423025   ENSP00000421974   ENSP00000394200   ENSP00000283126  

    GYPB Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for GYPB
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    Cloud-Clone Corp. Proteins for GYPB

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    LSBio Antibodies in human, mouse, rat for GYPB

    GYPB Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GYPB
    Cloud-Clone Corp. CLIAs for GYPB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    bloodgroup: Blood group antigens

    2 InterPro protein domains:
     IPR018938 Glycophorin_CS
     IPR001195 Glycophorin

    Graphical View of Domain Structure for InterPro Entry P06028

    ProtoNet protein and cluster: P06028

    1 Blocks protein domain: IPB001195 Glycophorin A and B

    UniProtKB/Swiss-Prot: GLPB_HUMAN, P06028
    Similarity: Belongs to the glycophorin-A family


    GYPB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLPB_HUMAN, P06028
    Function: This protein is a minor sialoglycoprotein in erythrocyte membranes

         Genatlas biochemistry entry for GYPB:
    glycophorin B (Ss specifity)

    Animal Models:
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    Predesigned siRNA for gene silencing in human, mouse, rat GYPB

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GYPB

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLPB_HUMAN, P06028: Cell membrane; Single-pass type I membrane protein

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS2295603
    GO:0005887integral component of plasma membrane TAS7622054
    GO:0016021integral component of membrane ----

    GYPB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GYPB About    
    See pathways by source

    SuperPathContained pathways About
    1Malaria
    Malaria

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for GYPB):
        Malaria


    GYPB for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GYPB
    Interactions:

        GeneGlobe Interaction Network for GYPB

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GYPB (GLPB)

    7 HMDB Compounds for GYPB    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-Myo-inositol 1,4-bisphosphate1D-Myo-inositol 1,4-bisphosphate (see all 5)47055-78-7--
    D-MannoseDL-mannose (see all 13)3458-28-4--
    Epimelibiose ----
    Galactosylglycerol3-beta-D-Galactosyl-sn-glycerol (see all 5)----
    Glycerol1,2,3-Trihydroxypropane (see all 22)56-81-5--
    Melibiitol6-O-alpha-D-Galactosyl-D-glucitol (see all 2)----
    Sorbitol(-)-Sorbitol (see all 60)50-70-4--

    10 Novoseek inferred chemical compound relationships for GYPB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polylactosamine 56.6 1 10698292 (1)
    sialic acid 56 4 8078523 (2), 1312416 (1), 18063920 (1)
    porphobilinogen 55.3 3 10207080 (1), 7858429 (1), 10828046 (1)
    5-aminolevulinic acid 25 2 10207080 (1), 10828046 (1)
    glycogen 16.8 5 10548038 (2), 1900534 (1), 10545198 (1)
    sulfate 0.482 4 1900534 (1)
    chloride 0 1 1385395 (1)
    tyrosine 0 1 10729812 (1)
    hydrogen 0 1 1900534 (1)
    serine 0 1 10729812 (1)



    GYPB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GYPB gene: 
    NM_002100.4  

    Unigene Cluster for GYPB:

    Glycophorin B (MNS blood group)
    Hs.654368  [show with all ESTs]
    Unigene Representative Sequence: NM_198682
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506679(uc011chu.1 uc010ioo.1 uc010iop.2 uc011chv.1 uc011chw.1 uc011chx.1 uc003ijm.1)
    ENST00000502664(uc011chz.2) ENST00000507009 ENST00000513128 ENST00000505583(uc011chy.1 uc011chs.1)
    ENST00000506516 ENST00000513557 ENST00000513677 ENST00000511198 ENST00000504951(uc011cht.1)
    ENST00000510196 ENST00000503255 ENST00000429670 ENST00000508618 ENST00000508841
    ENST00000283126(uc003ijn.2)
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat GYPB
      QuantiFast Probe-based Assays in human, mouse, rat GYPB

    Additional mRNA sequence: 

    AY509882.1 AY509883.1 AY950609.1 AY950610.1 AY950611.1 BC017864.1 BC069310.1 BC121077.1 
    BC121078.1 EU338223.1 EU338224.1 EU338225.1 EU338226.1 EU338227.1 EU338228.1 EU338229.1 
    EU338230.1 EU338235.1 EU338236.1 EU338237.1 EU338238.1 U05255.1 X08055.1 

    12 DOTS entries:

    DT.453077  DT.70103461  DT.121259100  DT.100839523  DT.86853840  DT.99985694  DT.40123213  DT.414934 
    DT.113224  DT.40111563  DT.95103342  DT.99974868 

    Selected AceView cDNA sequences (see all 88):

    BC017864 N55369 R93593 AA262967 CR617175 NM_198682 H60100 H69716 
    CR602358 AI288181 H79337 BG496433 X08055 BC069310 NM_002102 BU665206 
    BX325240 AI078357 BX091225 BC064396 M29610 AI086212 H59447 BV204894 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GYPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAACTGTA
    GYPB Expression
    About this image


    GYPB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Erythroblasts Hematopoietic Bone Marrow
             Bone Marrow CD105+ Cells   
             bone marrow mononuclear cells   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             bone marrow   
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Embryoid bodies
     
     Liver (Hepatobiliary System)
    GYPB Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.654368
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GYPB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for GYPB gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia GYPE6
    Glycophorin-E
    82(a)
    1 ↔ 1
    4(146747434-146896858)


    ENSEMBL Gene Tree for GYPB (if available)
    TreeFam Gene Tree for GYPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GYPB gene
    GYPE2  
    13 SIMAP similar genes for GYPB using alignment to 35 protein entries:     GLPB_HUMAN (see all proteins):
    HGpSta(C)    GYPE    MiIX    HGPMz    GPErik    GYPA
    GPSAT    GYP(B-A-B)    HGpMiVI    CARD8    HGpMiX    HGpMiV
    HGpMiXI

    GYPB for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GYPB
    PGOHUM00000250734 PGOHUM00000250735


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    GLPB_HUMAN, P06028: Along with GYPA, GYPB is responsible for the MNS blood group system. The molecular basis of the S/s
    blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 and Met-48 to S=MNS3


    Selected SNPs for GYPB (see all 818)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113837391,2
    C--140647546(+) AAAAA-/GCTTTA 1 -- int10--------
    rs717899701,2
    C--140647547(+) AAAAC-/GTTTAA 1 -- int10--------
    rs112859191,2
    C--140647643(+) CAAAA-/GTTTTA 1 -- int12Minor allele frequency- G:0.25NA CSA 4
    rs1117147041,2
    C--140647643(+) CAAAAA/G/TTTTTA 1 -- int10--------
    rs715904231,2
    C--140648125(+) AATGCAA/-AAAAA 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs178499721,2
    C--140651986(+) GAAGAG/AGTTGA 2 /T syn13Minor allele frequency- A:0.00NA 6
    rs745402181,2
    C--140658436(+) GTTCTC/ATTCCT 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1128748821,2
    C--140661924(+) CTCAGG/-AGTTG 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs773404411,2
    C--140682587(+) GAAGAC/TAGGGA 1 -- int11Minor allele frequency- T:0.00NA 2
    rs671686811,2
    C--140758200(+) ATTTT-/ATTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for GYPB (144917257 - 145061844 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GYPB (see all 56):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv978e199CNV Deletion23128226
    nsv436452CNV Deletion17901297
    esv2662558CNV Deletion23128226
    esv2421355CNV Deletion20811451
    esv2728481CNV Deletion23290073
    nsv435807CNV Deletion17901297
    esv2728476CNV Deletion23290073
    esv2728480CNV Deletion23290073
    nsv436411CNV Deletion17901297
    esv2668125CNV Deletion23128226

    Human Gene Mutation Database (HGMD): GYPB
    Locus Specific Mutation Databases (LSDB): GYPB

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GYPB
    DNA2.0 Custom Variant and Variant Library Synthesis for GYPB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 111740   
    OMIM disorders: 611162  
    13 diseases for GYPB:    
    About MalaCards
    malaria    cerebral malaria    congenital dyserythropoietic anemia    type 1 diabetes mellitus
    influenza    wiskott-aldrich syndrome    type 1 diabetes    cholestasis
    cholera    myelodysplastic syndromes    diabetes mellitus    sepsis
    cerebritis


    GYPB for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for GYPB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anemia dyserythropoietic congenital 76.6 4 2136385 (1), 7607254 (1), 10353717 (1)
    malaria 26.5 2 17372674 (1)
    influenza 0 5 8499461 (1), 2069581 (1)

    Genetic Association Database (GAD): GYPB
    Human Genome Epidemiology (HuGE) Navigator: GYPB (5 documents)

    Export disorders for GYPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GYPB gene, integrated from 10 sources (see all 144):
    (articles sorted by number of sources associating them with GYPB)
        Utopia: connect your pdf to the dynamic
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    1. The genotypes of GYPA and GYPB carrying the MNSs antigens are not associated with cerebral malaria. (PubMed id 17372674)1, 4, 9 Naka I....Tokunaga K. (J. Hum. Genet. 2007)
    2. The low-incidence MNS antigens M(v), s(D), and Mit arise from single amino acid substitutions on GPB. (PubMed id 11239234)1, 2, 9 Storry J.R.... Nortman P. (Transfusion 2001)
    3. Introduction of a real-time-based blood-group genotyping approach. (PubMed id 18510579)1, 4 Polin H....Gabriel C. (Vox Sang. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype. (PubMed id 1611092)1, 2 Huang C.-H.... Blumenfeld O.O. (Blood 1992)
    6. Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification. (PubMed id 2016325)1, 2 Huang C.-H. and Blumenfeld O.O. (J. Biol. Chem. 1991)
    7. Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences. (PubMed id 2734312)1, 2 Kudo S. and Fukuda M. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    8. Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta. (PubMed id 3196288)1, 2 Tate C.G. and Tanner M.J.A. (Biochem. J. 1988)
    9. Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis. (PubMed id 3571235)1, 2 Blanchard D....Cartron J.-P. (J. Biol. Chem. 1987)
    10. Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A. (PubMed id 3477806)1, 2 Siebert P.D. and Fukuda M. (Proc. Natl. Acad. Sci. U.S.A. 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2994 HGNC: 4703 AceView: GYPE Ensembl:ENSG00000250361 euGenes: HUgn2994
    ECgene: GYPB Kegg: 2994 H-InvDB: GYPB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GYPB Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=mns

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GYPB gene:
    Search GeneIP for patents involving GYPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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