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Aliases for GYPB Gene

Aliases for GYPB Gene

  • Glycophorin B (MNS Blood Group) 2 3 5
  • SS-Active Sialoglycoprotein 3 4
  • Sialoglycoprotein Delta 3 4
  • PAS-3 3 4
  • GPB 3 4
  • Glycophorin B/Glycophorin A Fusion Protein 3
  • Glycophorin B (Includes Ss Blood Group) 2
  • Glycophorin B (Ss Blood Group) 2
  • Hybrid Glycophorin Kip 3
  • GYPB/GYPA Fusion 3
  • Glycophorin Hop 3
  • Ss Blood Group 3
  • CD235b Antigen 4
  • CD235b 3
  • MNS 3
  • GYP 3
  • SS 3

External Ids for GYPB Gene

Previous HGNC Symbols for GYPB Gene

  • MNS

Previous GeneCards Identifiers for GYPB Gene

  • GC04M145713
  • GC04M145292
  • GC04M145495
  • GC04M145496
  • GC04M145274
  • GC04M145136
  • GC04M144918

Summaries for GYPB Gene

Entrez Gene Summary for GYPB Gene

  • Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for GYPB Gene

GYPB (Glycophorin B (MNS Blood Group)) is a Protein Coding gene. Diseases associated with GYPB include Short Stature, Idiopathic Familial and Leri-Weill Dyschondrosteosis. Among its related pathways are Malaria. An important paralog of this gene is GYPE.

UniProtKB/Swiss-Prot for GYPB Gene

  • This protein is a minor sialoglycoprotein in erythrocyte membranes.

Gene Wiki entry for GYPB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GYPB Gene

Genomics for GYPB Gene

Regulatory Elements for GYPB Gene

Enhancers for GYPB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GYPB on UCSC Golden Path with GeneCards custom track

Promoters for GYPB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GYPB on UCSC Golden Path with GeneCards custom track

Genomic Location for GYPB Gene

143,995,188 bp from pter
144,019,427 bp from pter
24,240 bases
Minus strand

Genomic View for GYPB Gene

Genes around GYPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GYPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GYPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GYPB Gene

Proteins for GYPB Gene

  • Protein details for GYPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B8Q174
    • E2QBW7
    • Q0VAF4
    • Q58HE9
    • Q58HF0
    • Q58HF1
    • Q9UCH7

    Protein attributes for GYPB Gene

    91 amino acids
    Molecular mass:
    9782 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GYPB Gene


neXtProt entry for GYPB Gene

Proteomics data for GYPB Gene at MOPED

Post-translational modifications for GYPB Gene

  • The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.
  • Glycosylation at Thr 36, Ser 38, and Thr 44
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GYPB Gene

Domains & Families for GYPB Gene

Gene Families for GYPB Gene

Protein Domains for GYPB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycophorin-A family.
  • Belongs to the glycophorin-A family.
genes like me logo Genes that share domains with GYPB: view

Function for GYPB Gene

Molecular function for GYPB Gene

GENATLAS Biochemistry:
glycophorin B (Ss specifity)
UniProtKB/Swiss-Prot Function:
This protein is a minor sialoglycoprotein in erythrocyte membranes.

Phenotypes for GYPB Gene

genes like me logo Genes that share phenotypes with GYPB: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GYPB Gene

Localization for GYPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for GYPB Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for GYPB Gene COMPARTMENTS Subcellular localization image for GYPB gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for GYPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 2295603
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GYPB: view

Pathways & Interactions for GYPB Gene

SuperPathways for GYPB Gene

Superpath Contained pathways
1 Malaria
genes like me logo Genes that share pathways with GYPB: view

Pathways by source for GYPB Gene

1 KEGG pathway for GYPB Gene

Interacting Proteins for GYPB Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000427690 P06028-GLPB_HUMAN for GYPB Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for GYPB Gene


No data available for SIGNOR curated interactions for GYPB Gene

Drugs & Compounds for GYPB Gene

(7) Drugs for GYPB Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-Myo-Inositol-1,4-Bisphosphate Experimental Pharma 0
Glycerol Experimental Pharma 205
Sorbitol Experimental Pharma 28

(10) Additional Compounds for GYPB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
  • (2R,3R,4S,5R,6R)-2-[(2R)-2,3-dihydroxypropoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  • 3-b-D-Galactosyl-sn-glycerol
  • 3-beta-D-Galactosyl-sn-glycerol
  • 3-beta-delta-Galactosyl-sn-glycerol
  • Azepan-2-one
  • 6-O-alpha-D-Galactosyl-D-glucitol
  • 6-O-alpha-delta-Galactosyl-delta-glucitol
genes like me logo Genes that share compounds with GYPB: view

Transcripts for GYPB Gene

Unigene Clusters for GYPB Gene

Glycophorin B (MNS blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GYPB Gene

No ASD Table

Relevant External Links for GYPB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GYPB Gene

mRNA expression in normal human tissues for GYPB Gene

mRNA differential expression in normal tissues according to GTEx for GYPB Gene

This gene is overexpressed in Whole Blood (x46.6).

SOURCE GeneReport for Unigene cluster for GYPB Gene Hs.654368

genes like me logo Genes that share expression patterns with GYPB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GYPB Gene

Orthologs for GYPB Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GYPB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GYPE 36
  • 82 (a)
Species with no ortholog for GYPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GYPB Gene

Gene Tree for GYPB (if available)
Gene Tree for GYPB (if available)

Paralogs for GYPB Gene

Paralogs for GYPB Gene Pseudogenes for GYPB Gene

genes like me logo Genes that share paralogs with GYPB: view

Variants for GYPB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GYPB Gene

Along with GYPA, GYPB is responsible for the MNS blood group system. The molecular basis of the S/s blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 and Met-48 to S=MNS3.

Sequence variations from dbSNP and Humsavar for GYPB Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs7683365 - 143,999,443(+) GTCCC(A/G)TTTCT reference, missense
rs1132783 - 143,997,559(-) TTACA(C/G)TATTC reference, missense
VAR_047948 -
VAR_047949 -
VAR_047950 -

Structural Variations from Database of Genomic Variants (DGV) for GYPB Gene

Variant ID Type Subtype PubMed ID
dgv1684e1 CNV Complex 17122850
nsv428452 CNV Loss 18775914
dgv1686e1 CNV Complex 17122850
esv2728476 CNV Deletion 23290073
dgv978e199 CNV Deletion 23128226
nsv436452 CNV Deletion 17901297
esv2752026 CNV Gain 17911159
dgv189e55 CNV Gain 17911159
dgv667n27 CNV Gain 19166990
dgv5767n71 CNV Gain 21882294
nsv517006 CNV Gain+Loss 19592680
nsv436078 CNV Insertion 17901297
nsv461664 CNV Gain 19166990
nsv461665 CNV Loss 19166990
nsv10584 CNV Gain+Loss 18304495
nsv880182 CNV Gain 21882294
dgv5769n71 CNV Gain 21882294
dgv1687e1 CNV Complex 17122850
esv2752030 CNV Gain 17911159
dgv1688e1 CNV Complex 17122850
nsv880191 CNV Gain+Loss 21882294
nsv436411 CNV Deletion 17901297
esv2728480 CNV Deletion 23290073
dgv5770n71 CNV Gain 21882294
esv2668125 CNV Deletion 23128226
dgv5771n71 CNV Gain 21882294
nsv880195 CNV Gain 21882294
nsv880196 CNV Loss 21882294
esv2421355 CNV Deletion 20811451
esv34775 CNV Loss 17911159
dgv1689e1 CNV Complex 17122850
nsv818281 CNV Loss 17921354
dgv1690e1 CNV Complex 17122850
dgv5772n71 CNV Gain 21882294
essv16952 CNV CNV 17122850
dgv5773n71 CNV Loss 21882294
nsv469732 CNV Gain 16826518
dgv5774n71 CNV Gain 21882294
dgv1691e1 CNV Complex 17122850
nsv436881 CNV Insertion 17901297
nsv435807 CNV Deletion 17901297
dgv668n27 CNV Gain 19166990
esv2662558 CNV Deletion 23128226
esv2728481 CNV Deletion 23290073
dgv1692e1 CNV Complex 17122850
dgv5775n71 CNV Gain 21882294
nsv880211 CNV Gain+Loss 21882294
esv29621 CNV Gain+Loss 19812545
nsv437438 CNV Loss 16327808
nsv822759 CNV Gain 20364138
nsv441919 CNV CNV 18776908
esv34834 CNV Gain 17911159
nsv514257 CNV Gain 21397061
nsv818282 CNV Gain 17921354
dgv669n27 CNV Gain 19166990
nsv437439 CNV Loss 16327808

Variation tolerance for GYPB Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GYPB Gene

Human Gene Mutation Database (HGMD)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

Disorders for GYPB Gene

MalaCards: The human disease database

(17) MalaCards diseases for GYPB Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
short stature, idiopathic familial
  • short stature, idiopathic, x-linked
leri-weill dyschondrosteosis
  • leri weill dyschondrosteosis
langer mesomelic dysplasia
  • dyschondrosteosis, homozygous
heterotopia, periventricular
  • periventricular nodular heterotopia 4
otopalatodigital syndrome, type i
  • oto-palato-digital syndrome type 1
- elite association - COSMIC cancer census association via MalaCards
Search GYPB in MalaCards View complete list of genes associated with diseases

Relevant External Links for GYPB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GYPB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GYPB Gene

Publications for GYPB Gene

  1. The genotypes of GYPA and GYPB carrying the MNSs antigens are not associated with cerebral malaria. (PMID: 17372674) Naka I. … Tokunaga K. (J. Hum. Genet. 2007) 3 23 48 67
  2. MNS blood group system: a review. (PMID: 20406014) Reid M.E. (Immunohematology 2009) 3 23
  3. An alloantibody to a high-prevalence MNS antigen in a person with a GP.JL/Mk phenotype. (PMID: 18284304) Ratliff J. … Reid M.E. (Immunohematology 2007) 3 23
  4. Quantification of glycophorin A and glycophorin B on normal human RBCs by flow cytometry. (PMID: 12869123) de Isla N.G. … Stoltz J.F. (Transfusion 2003) 3 23
  5. Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites. (PMID: 12949139) Wang H.Y. … Wu C.I. (Mol. Biol. Evol. 2003) 3 23

Products for GYPB Gene

Sources for GYPB Gene