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Aliases for GYPA Gene

Aliases for GYPA Gene

  • Glycophorin A (MNS Blood Group) 2 3
  • Glycophorin A (MN Blood Group) 2 3
  • Sialoglycoprotein Alpha 3 4
  • MN Sialoglycoprotein 3 4
  • PAS-2 3 4
  • GPA 3 4
  • Erythroid-Lineage-Specific Membrane Sialoglycoprotein 3
  • Recombinant Glycophorin A-B Miltenberger-DR 3
  • Glycophorin A (Includes MN Blood Group) 2
  • Mi.V Glycoprotein (24 AA) 3
  • Glycophorin Sta Type C 3
  • Glycophorin A, GPA 3
  • Glycophorin Erik 3
  • Glycophorin MiI 3
  • Glycophorin MiV 3
  • Glycophorin SAT 3
  • CD235a Antigen 4
  • HGpSta(C) 3
  • HGpMiXI 3
  • CD235a 3
  • GPErik 3
  • HGpMiV 3
  • GPSAT 3
  • MNS 3
  • MN 3

External Ids for GYPA Gene

Previous HGNC Symbols for GYPA Gene

  • MNS

Previous GeneCards Identifiers for GYPA Gene

  • GC04M145826
  • GC04M145405
  • GC04M145608
  • GC04M145388
  • GC04M145249
  • GC04M144917
  • GC04M145030
  • GC04M140759

Summaries for GYPA Gene

Entrez Gene Summary for GYPA Gene

  • Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]

GeneCards Summary for GYPA Gene

GYPA (Glycophorin A (MNS Blood Group)) is a Protein Coding gene. Diseases associated with GYPA include pyridoxine-responsive sideroblastic anemia and malaria. Among its related pathways are Malaria and Hematopoietic cell lineage. GO annotations related to this gene include protein homodimerization activity and virus receptor activity.

UniProtKB/Swiss-Prot for GYPA Gene

  • Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).

Gene Wiki entry for GYPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GYPA Gene

Genomics for GYPA Gene

Regulatory Elements for GYPA Gene

Genomic Location for GYPA Gene

Chromosome:
4
Start:
144,109,303 bp from pter
End:
144,140,752 bp from pter
Size:
31,450 bases
Orientation:
Minus strand

Genomic View for GYPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GYPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GYPA Gene

Proteins for GYPA Gene

  • Protein details for GYPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02724-GLPA_HUMAN
    Recommended name:
    Glycophorin-A
    Protein Accession:
    P02724
    Secondary Accessions:
    • A8K3E6
    • B8Q182
    • B8Q185
    • Q9BS51

    Protein attributes for GYPA Gene

    Size:
    150 amino acids
    Molecular mass:
    16331 Da
    Quaternary structure:
    • Homodimer. Interacts with Streptococcus gordonii hsa protein.
    Miscellaneous:
    • Involved in several unequal homologous recombinations or gene conversion events, predominantly with GYPB and more rarely with GYPE. The resulting fusion proteins are observed in different phenotypes and encode low incidence bloodgroup antigens
    SequenceCaution:
    • Sequence=AAA52624.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GYPA Gene

    Alternative splice isoforms for GYPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GYPA Gene

Proteomics data for GYPA Gene at MOPED

Post-translational modifications for GYPA Gene

  • The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).
  • Glycosylation at Ser 21, Thr 22, Thr 23, Thr 29, Ser 30, Thr 31, Ser 32, Thr 36, Ser 38, Ser 41, Thr 44, Asn 45, Thr 52, Thr 56, Ser 63, Ser 66, and Thr 69
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GYPA Gene

Domains & Families for GYPA Gene

Gene Families for GYPA Gene

Protein Domains for GYPA Gene

Graphical View of Domain Structure for InterPro Entry

P02724

UniProtKB/Swiss-Prot:

GLPA_HUMAN :
  • Belongs to the glycophorin A family.
Family:
  • Belongs to the glycophorin A family.
genes like me logo Genes that share domains with GYPA: view

Function for GYPA Gene

Molecular function for GYPA Gene

GENATLAS Biochemistry:
glycophorin A (MN specificity),erythroid specific
UniProtKB/Swiss-Prot Function:
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).

Gene Ontology (GO) - Molecular Function for GYPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0003674 molecular_function --
GO:0042802 identical protein binding IPI 14681217
GO:0042803 protein homodimerization activity --
genes like me logo Genes that share ontologies with GYPA: view

Phenotypes for GYPA Gene

GenomeRNAi human phenotypes for GYPA:
genes like me logo Genes that share phenotypes with GYPA: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GYPA Gene

Localization for GYPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GYPA Gene

Cell membrane; Single-pass type I membrane protein. Note=Appears to be colocalized with SLC4A1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GYPA Gene COMPARTMENTS Subcellular localization image for GYPA gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
cytosol 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GYPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane --
GO:0009897 external side of plasma membrane --
GO:0016020 membrane TAS 3456608
genes like me logo Genes that share ontologies with GYPA: view

Pathways & Interactions for GYPA Gene

SuperPathways for GYPA Gene

genes like me logo Genes that share pathways with GYPA: view

Pathways by source for GYPA Gene

2 KEGG pathways for GYPA Gene

Interacting Proteins for GYPA Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354003%0d%0a9606.ENSP00000171111%0d%0a9606.ENSP00000221566%0d%0a
Selected Interacting proteins: P02724-GLPA_HUMAN ENSP00000354003 for GYPA Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for GYPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007016 cytoskeletal anchoring at plasma membrane --
GO:0008150 biological_process --
GO:0046718 viral entry into host cell IEA --
GO:0047484 regulation of response to osmotic stress --
genes like me logo Genes that share ontologies with GYPA: view

No data available for SIGNOR curated interactions for GYPA Gene

Drugs & Compounds for GYPA Gene

(6) Drugs for GYPA Gene - From: DGIdb and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hypoxanthine Experimental Pharma 0
WX-G250 Investigational Pharma 0
alanine Nutra 97
arginine Nutra 346
Calcium Nutra 0

(13) Additional Compounds for GYPA Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
butyrate
chloride
DIMYRISTOYLPHOSPHATIDYLCHOLINE
GLYCOLIPID
HBGG
genes like me logo Genes that share compounds with GYPA: view

Transcripts for GYPA Gene

Unigene Clusters for GYPA Gene

Glycophorin A (MNS blood group):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GYPA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GYPA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for GYPA Gene

GeneLoc Exon Structure for
GYPA
ECgene alternative splicing isoforms for
GYPA

Expression for GYPA Gene

mRNA expression in normal human tissues for GYPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GYPA Gene

This gene is overexpressed in Whole Blood (x34.3) and Spleen (x4.9).

Protein differential expression in normal tissues from HIPED for GYPA Gene

This gene is overexpressed in Lavage (25.5), Neutrophil (14.6), Skin (14.2), and Placenta (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GYPA Gene



SOURCE GeneReport for Unigene cluster for GYPA Gene Hs.434973

genes like me logo Genes that share expression patterns with GYPA: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GYPA Gene

Orthologs for GYPA Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for GYPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GYPA 35
  • 93.51 (n)
  • 85.91 (a)
GYPA 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gypa 36
  • 26 (a)
OneToOne
Species with no ortholog for GYPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GYPA Gene

ENSEMBL:
Gene Tree for GYPA (if available)
TreeFam:
Gene Tree for GYPA (if available)

Paralogs for GYPA Gene

genes like me logo Genes that share paralogs with GYPA: view

No data available for Paralogs for GYPA Gene

Variants for GYPA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GYPA Gene

P02724-GLPA_HUMAN
Along with GYPB, GYPA is responsible for the MNS blood group system. The molecular basis of the GPA M/N bloodgroup antigen is a variation at positions 20 and 24. Ser-20 and Gly-24 correspond to M (shown); Leu-20 and Glu-24 correspond to N

Sequence variations from dbSNP and Humsavar for GYPA Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_003190 -
VAR_003191 -
VAR_058911 -, -
VAR_058912 -
VAR_058913 -

Structural Variations from Database of Genomic Variants (DGV) for GYPA Gene

Variant ID Type Subtype PubMed ID
dgv1684e1 CNV Complex 17122850
nsv428452 CNV Loss 18775914
dgv1686e1 CNV Complex 17122850
esv2728476 CNV Deletion 23290073
esv2752026 CNV Gain 17911159
dgv189e55 CNV Gain 17911159
dgv5767n71 CNV Gain 21882294
nsv517006 CNV Gain+Loss 19592680
nsv10584 CNV Gain+Loss 18304495
dgv1688e1 CNV Complex 17122850
nsv880191 CNV Gain+Loss 21882294
nsv436411 CNV Deletion 17901297
esv2728480 CNV Deletion 23290073
dgv5770n71 CNV Gain 21882294
dgv1690e1 CNV Complex 17122850
essv16952 CNV CNV 17122850
nsv469732 CNV Gain 16826518
dgv5774n71 CNV Gain 21882294
dgv1691e1 CNV Complex 17122850
dgv668n27 CNV Gain 19166990
esv2728481 CNV Deletion 23290073
dgv1692e1 CNV Complex 17122850
dgv5775n71 CNV Gain 21882294
nsv880211 CNV Gain+Loss 21882294
nsv822759 CNV Gain 20364138
esv34834 CNV Gain 17911159
nsv514257 CNV Gain 21397061
nsv818282 CNV Gain 17921354
dgv669n27 CNV Gain 19166990
dgv5776n71 CNV Gain 21882294
nsv880224 CNV Loss 21882294
dgv5777n71 CNV Gain 21882294
dgv5778n71 CNV Gain 21882294
nsv880230 CNV Gain 21882294
nsv880231 CNV Gain 21882294

Variation tolerance for GYPA Gene

Residual Variation Intolerance Score: 65.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GYPA Gene

HapMap Linkage Disequilibrium report
GYPA
Human Gene Mutation Database (HGMD)
GYPA
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

Disorders for GYPA Gene

MalaCards: The human disease database

(10) MalaCards diseases for GYPA Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
pyridoxine-responsive sideroblastic anemia
  • x chromosome-linked pyridoxine responsive sideroblastic anemia
malaria
  • malaria, severe
fetal erythroblastosis
  • haemolytic disease due to rhesus isoimmunisation
anemia of prematurity
leukemoid reaction
- elite association
Search GYPA in MalaCards View complete list of genes associated with diseases

Relevant External Links for GYPA

Genetic Association Database (GAD)
GYPA
Human Genome Epidemiology (HuGE) Navigator
GYPA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GYPA
genes like me logo Genes that share disorders with GYPA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GYPA Gene

Publications for GYPA Gene

  1. Molecular dynamics simulations of the dimerization of transmembrane alpha-helices. (PMID: 20017540) Psachoulia E. … Sansom M.S. (Acc. Chem. Res. 2010) 23 67
  2. ABH blood group antigens in N-glycan of human glycophorin A. (PMID: 20434428) Fredriksson S.A. … Krotkiewski H. (Arch. Biochem. Biophys. 2010) 23 67
  3. C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex. (PMID: 19258706) Karnchanaphanurach P. … Golan D.E. (J. Clin. Invest. 2009) 23 67
  4. Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3. (PMID: 19564639) Hsu K. … Foster D.B. (Blood 2009) 23 67
  5. Interaction of anion exchanger 1 and glycophorin A in human erythroleukaemic K562 cells. (PMID: 19438409) Pang A.J. … Reithmeier R.A. (Biochem. J. 2009) 23 67

Products for GYPA Gene

Sources for GYPA Gene

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