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GYG2 Gene

protein-coding   GIFtS: 65
GCID: GC0XP002740

Glycogenin 2

  See GYG2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycogenin 21 2
GN22 3 5
Glycogenin Glucosyltransferase1 2
GN-22 3
EC 2.4.1.1863 8
glycogenin-22

External Ids:    HGNC: 47001   Entrez Gene: 89082   Ensembl: ENSG000000569987   OMIM: 3001985   UniProtKB: O154883   

Export aliases for GYG2 gene to outside databases

Previous GC identifers: GC0XP002051 GC0XP001915 GC0XP002276 GC0XP002341 GC0XP000690


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GYG2 Gene:
This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in
the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this
X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis.
This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein.
Multiple alternatively spliced transcript variants encoding different isoforms have been identified.(provided by
RefSeq, May 2010)

GeneCards Summary for GYG2 Gene:
GYG2 (glycogenin 2) is a protein-coding gene. Diseases associated with GYG2 include glycogen storage disease type 0. GO annotations related to this gene include glycogenin glucosyltransferase activity. An important paralog of this gene is GYG1.

UniProtKB/Swiss-Prot: GLYG2_HUMAN, O15488
Function: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as
substrate for glycogen synthase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for GYG2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGYG2 promoter sequence
   Search Chromatin IP Primers for GYG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GYG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3

GYG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GYG2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP002740:  view genomic region     (about GC identifiers)

Start:
2,746,829 bp from pter      End:
2,800,861 bp from pter
Size:
54,033 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GLYG2_HUMAN, O15488 (See protein sequence)
Recommended Name: Glycogenin-2  
Size: 501 amino acids; 55184 Da
Cofactor: Divalent metal ions. Required for self-glucosylation. Manganese is the most effective
Subunit: Homodimer, tightly complexed to glycogen synthase
Mass spectrometry: Mass=55211.89; Method=MALDI; Range=1-501; Source=PubMed:11840567;
Secondary accessions: B7WNN6 O15485 O15486 O15487 O15489 O15490
Alternative splicing: 6 isoforms:  O15488-1   O15488-2   O15488-3   O15488-4   O15488-5   O15488-6   

Explore the universe of human proteins at neXtProt for GYG2: NX_O15488

Explore proteomics data for GYG2 at MOPED

Post-translational modifications: 

  • Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of
    around 10 residues attached to Tyr-2281
  • Glycosylation2 at Tyr228
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for GYG2 (O15488)
     TLTKLHCW  TDQAFVTL  AKVVHFLG  SAAPDPGWPDCFNSGVFV 


    See GYG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001073324.1  NP_001171631.1  NP_001171632.1  NP_001171633.1  NP_003909.2  

    ENSEMBL proteins: 
     ENSP00000381786   ENSP00000370555   ENSP00000430764   ENSP00000370549   ENSP00000341273  
     ENSP00000446092  
    Reactome Protein details: O15488

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    antibodies-online proteins for GYG2 (7 products) 

     
    antibodies-online peptides for GYG2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GLT8: Glycosyltransferase family 8 domain containing

    1 InterPro protein domain:
     IPR002495 Glyco_trans_8

    Graphical View of Domain Structure for InterPro Entry O15488

    ProtoNet protein and cluster: O15488

    1 Blocks protein domain: IPB002495 Glycosyl transferase

    UniProtKB/Swiss-Prot: GLYG2_HUMAN, O15488
    Similarity: Belongs to the glycosyltransferase 8 family. Glycogenin subfamily


    Find genes that share domains with GYG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLYG2_HUMAN, O15488
    Function: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as
    substrate for glycogen synthase
    Catalytic activity: UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin

         Genatlas biochemistry entry for GYG2:
    glycogenin self glycosylating protein 2,interacting with GYG,involved in initiation phase of glycogen
    biosynthesis,preferentially expressed in liver,heart and pancreas with several tissue specific,alternatively
    spliced isoforms

         Enzyme Number (IUBMB): EC 2.4.1.1861 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008466glycogenin glucosyltransferase activity EXP--
    GO:0016757transferase activity, transferring glycosyl groups ----
         
    Find genes that share ontologies with GYG2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GYG2

    miRNA
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    miRTarBase miRNAs that target GYG2:
    hsa-mir-24-3p (MIRT030406)

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    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-miR-196a hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidGYG2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with GYG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GYG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Glucose metabolism
    Glucose metabolism0.44
    Glycogen breakdown (glycogenolysis)0.00
    Glycogen synthesis0.00
    glycogen biosynthesis II (from UDP-D-Glucose)0.00
    2MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45
    3Metabolism
    Metabolism0.38
    4Glycogen Metabolism
    Glycogen Metabolism


    Find genes that share SuperPaths with GYG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GYG2
        Glycogen Metabolism
    glycogen biosynthesis II (from UDP-D-Glucose)


    3 Reactome Pathways for GYG2
        Glycogen synthesis
    Glycogen breakdown (glycogenolysis)
    Myoclonic epilepsy of Lafora


    UniProtKB/Swiss-Prot: GLYG2_HUMAN, O15488
    Pathway: Glycan biosynthesis; glycogen biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GYG2
    Interactions:

        Search GeneGlobe Interaction Network for GYG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for GYG2 (O154882, 3 ENSP000003705554) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GYS1P138073, ENSP000003179044I2D: score=3 STRING: ENSP00000317904
    GYG1P469763, ENSP000003407364I2D: score=2 STRING: ENSP00000340736
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    MFAP5ENSP000003524554STRING: ENSP00000352455
    LSM5ENSP000004107584STRING: ENSP00000410758
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0005978glycogen biosynthetic process TAS--
    GO:0005980glycogen catabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with GYG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for GYG2 (GLYG2)

    4 HMDB Compounds for GYG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    GlycogenAnimal starch (see all 5)9005-79-2--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucose(UPD)-glucose (see all 24)133-89-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GYG2 gene (5 alternative transcripts): 
    NM_001079855.1  NM_001184702.1  NM_001184703.1  NM_001184704.1  NM_003918.2  

    Unigene Cluster for GYG2:

    Glycogenin 2
    Hs.567381  [show with all ESTs]
    Unigene Representative Sequence: NM_003918
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398806 ENST00000381163(uc004cqs.1 uc004cqu.1 uc004cqx.2 uc004cqt.1 uc004cqv.1 uc004cqw.1 uc010ndc.1)
    ENST00000381161 ENST00000520904 ENST00000469234 ENST00000353656 ENST00000453106
    ENST00000381157 ENST00000338623 ENST00000542787
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    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-miR-196a hsa-let-7e hsa-let-7g
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    Additional mRNA sequence: 

    AK098046.1 AK292496.1 BC023152.1 DQ424901.1 U94357.1 U94358.1 U94360.1 U94361.1 
    U94362.1 U94363.1 

    9 DOTS entries:

    DT.91755536  DT.87003736  DT.91755531  DT.87016555  DT.121322734  DT.121322735  DT.102824391  DT.100026695 
    DT.100826532 

    Selected AceView cDNA sequences (see all 104):

    AL703271 CD515269 BQ676160 BU557030 U94358 BQ645138 CB410312 BU553781 
    BU553391 CD657644 U94363 CD512028 U94361 BU850311 BQ695377 BU167424 
    BM999109 AK098046 BM702362 R48469 BM770550 BM765320 BG281534 AI018294 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GYG2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d
    SP1:              -                                                                                                     -                           
    SP2:                                -                                                                                   -                           
    SP3:                                                                                                                                                
    SP4:              -                 -                                                                                                               
    SP5:                                                                                                              -     -                           


    ECgene alternative splicing isoforms for GYG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GYG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACGGGCA
    GYG2 Expression
    About this image


    GYG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    GYG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GYG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567381

    UniProtKB/Swiss-Prot: GLYG2_HUMAN, O15488
    Tissue specificity: Expressed preferentially in liver, heart, and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GYG2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia GYG21 glycogenin 2 79.72(n)
    76.73(a)
      491717  XM_005641067.1  XP_005641124.1 
    chicken
    (Gallus gallus)
    Aves GYG21 glycogenin 2 61.22(n)
    61.22(a)
      418660  XM_416857.4  XP_416857.4 
    lizard
    (Anolis carolinensis)
    Reptilia GYG26
    glycogenin 2
    55(a)
    1 ↔ 1
    3(113912561-113935723)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gyg21 glycogenin 2 60.03(n)
    57.25(a)
      496877  NM_001011403.1  NP_001011403.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gyg26
    glycogenin 2
    44(a)
    many ↔ many
    1(33002715-33019030) ENSDARG00000033380
    fruit fly
    (Drosophila melanogaster)
    Insecta Glycogenin6
    Glycogenin
    24(a)
    1 → many
    2R(17087988-17100474)
    worm
    (Caenorhabditis elegans)
    Secernentea T25E12.53
    gyg-11
    glycogenin3
    gyg-11
    50(a)
    (best of 3)3
    56.85(n)1
    53.25(a)1
      V(16747829-16748840)3
    1806441  NM_171944.41  NP_741749.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLG26
    GLG16
    Self-glucosylating initiator of glycogen synthesis...
    Self-glucosylating initiator of glycogen synthesis...
    24(a)
    18(a)
    many ↔ many
    many ↔ many
    X(154985-156127) YJL137C
    XI(552770-554620) YKR058W


    ENSEMBL Gene Tree for GYG2 (if available)
    TreeFam Gene Tree for GYG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GYG2 gene
    GYG12  
    1 SIMAP similar gene for GYG2 using alignment to 3 protein entries:     GLYG2_HUMAN (see all proteins):
    GYG1

    Find genes that share paralogs with GYG2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GYG2
    PGOHUM00000256886


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GYG2 (see all 1293)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928807361,2
    --2718431(+) TGCTGC/TCTCTT 5 -- us2k10--------
    rs1472186661,2
    C--2718449(+) GACACA/GTGAAG 5 -- us2k10--------
    rs1405643341,2
    C--2718491(+) TCATGC/TACTCA 5 -- us2k10--------
    rs625822841,2
    C--2718508(+) CATGCC/ACTCAC 5 -- us2k13Minor allele frequency- A:0.00NA 4
    rs2006631541,2
    C--2718628(+) CATGCA/CCTCAC 5 -- us2k10--------
    rs1893704191,2
    --2718872(+) CATTCA/TCTCAT 5 -- us2k10--------
    rs1500039891,2
    --2719004(+) CATTCA/GGCCAC 5 -- us2k10--------
    rs1924191811,2
    --2719178(+) TGTACA/GAATTC 5 -- us2k10--------
    rs23162891,2
    C--2719348(-) acaagC/Tgaatt 5 -- us2k1 tfbs31Minor allele frequency- T:0.00NA 2
    rs23162881,2
    C--2719349(-) aacaaG/Acgaat 5 -- us2k1 tfbs32Minor allele frequency- A:0.00NA 4

    HapMap Linkage Disequilibrium report for GYG2 (2746829 - 2800861 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GYG2 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739889CNV Deletion23290073
    esv2739893CNV Deletion23290073
    esv2739888CNV Deletion23290073
    esv2739894CNV Deletion23290073
    dgv1392e199CNV Deletion23128226
    esv2739883CNV Deletion23290073
    esv2739890CNV Deletion23290073
    esv2739891CNV Deletion23290073
    esv2739892CNV Deletion23290073
    nsv526612CNV Loss19592680

    Human Gene Mutation Database (HGMD): GYG2
    Locus Specific Mutation Databases (LSDB): GYG2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GYG2
    DNA2.0 Custom Variant and Variant Library Synthesis for GYG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300198    OMIM disorders: --

    1 disease for GYG2:    
    About MalaCards
    glycogen storage disease type 0


    Find genes that share disorders with GYG2           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: GYG2 (1 document)

    Export disorders for GYG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GYG2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with GYG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism. (PubMed id 9857012)1, 2, 3, 9 Mu J. and Roach P.J. (J. Biol. Chem. 1998)
    2. Structure and chromosomal localization of the human glycogenin-2 gene GYG2. (PubMed id 10721716)1, 2, 9 Zhai L.... Roach P.J. (Gene 2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (Proteomics 2002)
    5. Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis. (PubMed id 9346895)1, 2 Mu J.... Roach P.J. (J. Biol. Chem. 1997)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (Nature 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Expanding the substantial interactome of NEMO using protein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8908 HGNC: 4700 AceView: GYG2 Ensembl:ENSG00000056998 euGenes: HUgn8908
    ECgene: GYG2 H-InvDB: GYG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GYG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GYG2 gene:
    Search GeneIP for patents involving GYG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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