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Aliases for GYG2 Gene

Aliases for GYG2 Gene

  • Glycogenin 2 2 3
  • GN2 3 4 6
  • Glycogenin Glucosyltransferase 2 3
  • EC 2.4.1.186 4 64
  • GN-2 3 4
  • Glycogenin-2 3

External Ids for GYG2 Gene

Summaries for GYG2 Gene

Entrez Gene Summary for GYG2 Gene

  • This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

GeneCards Summary for GYG2 Gene

GYG2 (Glycogenin 2) is a Protein Coding gene. Diseases associated with GYG2 include glycogen storage disease type 0. Among its related pathways are Metabolism and MPS VI - Maroteaux-Lamy syndrome. GO annotations related to this gene include glycogenin glucosyltransferase activity. An important paralog of this gene is GYG1.

UniProtKB/Swiss-Prot for GYG2 Gene

  • Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GYG2 Gene

Genomics for GYG2 Gene

Genomic Location for GYG2 Gene

Start:
2,828,744 bp from pter
End:
2,882,820 bp from pter
Size:
54,077 bases
Orientation:
Plus strand

Genomic View for GYG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GYG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GYG2 Gene

No data available for Regulatory Elements for GYG2 Gene

Proteins for GYG2 Gene

  • Protein details for GYG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15488-GLYG2_HUMAN
    Recommended name:
    Glycogenin-2
    Protein Accession:
    O15488
    Secondary Accessions:
    • B7WNN6
    • O15485
    • O15486
    • O15487
    • O15489
    • O15490

    Protein attributes for GYG2 Gene

    Size:
    501 amino acids
    Molecular mass:
    55184 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.;
    Quaternary structure:
    • Homodimer, tightly complexed to glycogen synthase

    Three dimensional structures from OCA and Proteopedia for GYG2 Gene

    Alternative splice isoforms for GYG2 Gene

neXtProt entry for GYG2 Gene

Proteomics data for GYG2 Gene at MOPED

Selected DME Specific Peptides for GYG2 Gene

Post-translational modifications for GYG2 Gene

  • Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-228.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Tyr228

Other Protein References for GYG2 Gene

Domains for GYG2 Gene

Gene Families for GYG2 Gene

HGNC:
  • GLT8 :Glycosyltransferase family 8 domain containing

Protein Domains for GYG2 Gene

UniProtKB/Swiss-Prot:

GLYG2_HUMAN
Family:
  • Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.:
    • O15488
genes like me logo Genes that share domains with GYG2: view

Function for GYG2 Gene

Molecular function for GYG2 Gene

GENATLAS Biochemistry: glycogenin self glycosylating protein 2,interacting with GYG,involved in initiation phase of glycogen biosynthesis,preferentially expressed in liver,heart and pancreas with several tissue specific,alternatively spliced isoforms
UniProtKB/Swiss-Prot CatalyticActivity: UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
UniProtKB/Swiss-Prot Function: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase

Enzyme Numbers (IUBMB) for GYG2 Gene

Gene Ontology (GO) - Molecular Function for GYG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008466 glycogenin glucosyltransferase activity EXP --
GO:0016757 transferase activity, transferring glycosyl groups --
genes like me logo Genes that share ontologies with GYG2: view

miRNA for GYG2 Gene

miRTarBase miRNAs that target GYG2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GYG2 Gene

Localization for GYG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GYG2 Gene COMPARTMENTS Subcellular localization image for GYG2 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GYG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with GYG2: view

Pathways for GYG2 Gene

genes like me logo Genes that share pathways with GYG2: view

UniProtKB/Swiss-Prot O15488-GLYG2_HUMAN

  • Pathway: Glycan biosynthesis; glycogen biosynthesis

Gene Ontology (GO) - Biological Process for GYG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005978 glycogen biosynthetic process TAS --
GO:0005980 glycogen catabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with GYG2: view

Compounds for GYG2 Gene

(4) HMDB Compounds for GYG2 Gene

Compound Synonyms Cas Number PubMed IDs
Glycogen
  • Animal starch
9005-79-2
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate glucose
  • (UPD)-glucose
133-89-1
genes like me logo Genes that share compounds with GYG2: view

Transcripts for GYG2 Gene

Unigene Clusters for GYG2 Gene

Glycogenin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GYG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d
SP1: - -
SP2: - -
SP3:
SP4: - -
SP5: - -
SP6: -
SP7: - -
SP8: - - -

Relevant External Links for GYG2 Gene

GeneLoc Exon Structure for
GYG2
ECgene alternative splicing isoforms for
GYG2

Expression for GYG2 Gene

mRNA expression in normal human tissues for GYG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GYG2 Gene

This gene is overexpressed in Adipose - Subcutaneous (10.4), Adipose - Visceral (Omentum) (9.2), Breast - Mammary Tissue (4.8), and Brain - Spinal cord (cervical c-1) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GYG2 Gene

SOURCE GeneReport for Unigene cluster for GYG2 Gene Hs.567381

mRNA Expression by UniProt/SwissProt for GYG2 Gene

O15488-GLYG2_HUMAN
Tissue specificity: Expressed preferentially in liver, heart, and pancreas
genes like me logo Genes that share expressions with GYG2: view

Orthologs for GYG2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GYG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GYG2 36
  • 99.13 (n)
  • 99.05 (a)
GYG2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GYG2 36
  • 76.63 (n)
  • 73.18 (a)
GYG2 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GYG2 36
  • 79.72 (n)
  • 76.73 (a)
GYG2 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GYG2 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GYG2 37
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GYG2 36
  • 61.22 (n)
  • 61.22 (a)
GYG2 37
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GYG2 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gyg2 36
  • 60.03 (n)
  • 57.25 (a)
zebrafish
(Danio rerio)
Actinopterygii gyg2 37
  • 44 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Glycogenin 37
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gyg-1 36
  • 56.85 (n)
  • 53.25 (a)
gyg-1 37
  • 37 (a)
ManyToMany
gyg-2 37
  • 45 (a)
ManyToMany
M116.2 37
  • 45 (a)
ManyToMany
M116.2 38
  • 49 (a)
Y73F8A.31 38
  • 46 (a)
T25E12.5 38
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLG1 37
  • 18 (a)
ManyToMany
GLG2 37
  • 24 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2083 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToMany
Species with no ortholog for GYG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GYG2 Gene

ENSEMBL:
Gene Tree for GYG2 (if available)
TreeFam:
Gene Tree for GYG2 (if available)

Paralogs for GYG2 Gene

Paralogs for GYG2 Gene

Selected SIMAP similar genes for GYG2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GYG2 Gene

genes like me logo Genes that share paralogs with GYG2: view

Variants for GYG2 Gene

Sequence variations from dbSNP and Humsavar for GYG2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1268 -- 2,882,636(+) TCAGA(A/G)GGAGA utr-variant-3-prime
rs1269 -- 2,882,583(-) CGAGC(A/C)TCGCC utr-variant-3-prime
rs9355 -- 2,882,747(+) ATTCC(A/C/G)CCGTG utr-variant-3-prime
rs12325 -- 2,882,567(+) ATCGT(C/T)AGTCT utr-variant-3-prime
rs211659 -- 2,881,438(+) TCTTC(A/T)GAGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GYG2 Gene

Variant ID Type Subtype PubMed ID
dgv2432e1 CNV Complex 17122850
esv34985 CNV Gain 17911159
dgv1392e199 CNV Deletion 23128226
esv2739883 CNV Deletion 23290073
nsv516388 CNV Gain 19592680
nsv526612 CNV Loss 19592680
dgv264e55 CNV Gain 17911159
essv21575 CNV CNV 17122850
essv3621 CNV CNV 17122850
esv32744 CNV Loss 17666407
esv2739888 CNV Deletion 23290073
esv2739889 CNV Deletion 23290073
esv2739890 CNV Deletion 23290073
esv2739891 CNV Deletion 23290073
esv2739892 CNV Deletion 23290073
esv2739893 CNV Deletion 23290073
esv2739894 CNV Deletion 23290073

Relevant External Links for GYG2 Gene

HapMap Linkage Disequilibrium report
GYG2
Human Gene Mutation Database (HGMD)
GYG2
Locus Specific Mutation Databases (LSDB)
GYG2

Disorders for GYG2 Gene

Relevant External Links for GYG2

Human Genome Epidemiology (HuGE) Navigator
GYG2
genes like me logo Genes that share disorders with GYG2: view

No data available for UniProtKB/Swiss-Prot for GYG2 Gene

Publications for GYG2 Gene

  1. Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism. (PMID: 9857012) Mu J. … Roach P.J. (J. Biol. Chem. 1998) 2 3 4 23
  2. Structure and chromosomal localization of the human glycogenin-2 gene GYG2. (PMID: 10721716) Zhai L. … Roach P.J. (Gene 2000) 3 4 23
  3. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PMID: 11840567) Harris R.A. … Zvelebil M.J. (Proteomics 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis. (PMID: 9346895) Mu J. … Roach P.J. (J. Biol. Chem. 1997) 3 4

Products for GYG2 Gene

Sources for GYG2 Gene

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