Aliases for GUSB Gene
External Ids for GUSB Gene
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]
GeneCards Summary for GUSB Gene
GUSB (Glucuronidase, Beta) is a Protein Coding gene. Diseases associated with GUSB include necrotizing ulcerative gingivitis and immune hydrops fetalis. Among its related pathways are Disease and Lysosome. GO annotations related to this gene include beta-glucuronidase activity.
UniProtKB/Swiss-Prot for GUSB Gene
Plays an important role in the degradation of dermatan and keratan sulfates