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Aliases for GULP1 Gene

Aliases for GULP1 Gene

  • GULP, Engulfment Adaptor PTB Domain Containing 1 2 3 5
  • PTB Domain Adapter Protein CED-6 3 4
  • Cell Death Protein 6 Homolog 3 4
  • CED6 3 4
  • GULP 3 4
  • PTB Domain Adaptor Protein CED-6 3
  • Engulfment Adapter Protein 3
  • Protein GULP 4
  • CED-6 3

External Ids for GULP1 Gene

Previous GeneCards Identifiers for GULP1 Gene

  • GC02P189358
  • GC02P189360
  • GC02P188981
  • GC02P188864
  • GC02P189156
  • GC02P181017

Summaries for GULP1 Gene

Entrez Gene Summary for GULP1 Gene

  • The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for GULP1 Gene

GULP1 (GULP, Engulfment Adaptor PTB Domain Containing 1) is a Protein Coding gene. Among its related pathways are Arf6 signaling events. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is NUMB.

UniProtKB/Swiss-Prot for GULP1 Gene

  • May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GULP1 Gene

Genomics for GULP1 Gene

Regulatory Elements for GULP1 Gene

Promoters for GULP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GULP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GULP1 Gene

Chromosome:
2
Start:
188,291,669 bp from pter
End:
188,595,931 bp from pter
Size:
304,263 bases
Orientation:
Plus strand

Genomic View for GULP1 Gene

Genes around GULP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GULP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GULP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GULP1 Gene

Proteins for GULP1 Gene

  • Protein details for GULP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBP9-GULP1_HUMAN
    Recommended name:
    PTB domain-containing engulfment adapter protein 1
    Protein Accession:
    Q9UBP9
    Secondary Accessions:
    • B2RB51
    • B4DQ40
    • B8ZZ72
    • D3DPH1
    • E9PB86
    • Q53PC1
    • Q53RF3
    • Q9BVL3

    Protein attributes for GULP1 Gene

    Size:
    304 amino acids
    Molecular mass:
    34490 Da
    Quaternary structure:
    • Homodimer. Interacts with clathrin. Interacts with GDP-bound ARF6, but not with GTP-bound ARF6. Part of a complex composed of GULP1, ACAP1 and ARF6. Interacts with ACAP1, LRP1, MEGF10 and STAB2.

    Alternative splice isoforms for GULP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GULP1 Gene

Proteomics data for GULP1 Gene at MOPED

Post-translational modifications for GULP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for GULP1 Gene

Domains & Families for GULP1 Gene

Protein Domains for GULP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GULP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBP9

UniProtKB/Swiss-Prot:

GULP1_HUMAN :
  • Contains 1 PID domain.
  • Belongs to the ced-6 family.
Domain:
  • Contains 1 PID domain.
Family:
  • Belongs to the ced-6 family.
genes like me logo Genes that share domains with GULP1: view

No data available for Gene Families for GULP1 Gene

Function for GULP1 Gene

Molecular function for GULP1 Gene

UniProtKB/Swiss-Prot Function:
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
genes like me logo Genes that share phenotypes with GULP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GULP1 Gene

Localization for GULP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GULP1 Gene

Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GULP1 Gene COMPARTMENTS Subcellular localization image for GULP1 gene
Compartment Confidence
cytosol 2
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for GULP1 Gene

Pathways & Interactions for GULP1 Gene

SuperPathways for GULP1 Gene

Superpath Contained pathways
1 Arf6 signaling events
genes like me logo Genes that share pathways with GULP1: view

Pathways by source for GULP1 Gene

1 BioSystems pathway for GULP1 Gene

Gene Ontology (GO) - Biological Process for GULP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006911 phagocytosis, engulfment IDA 11729193
GO:0007165 signal transduction TAS 10574763
genes like me logo Genes that share ontologies with GULP1: view

No data available for SIGNOR curated interactions for GULP1 Gene

Drugs & Compounds for GULP1 Gene

(1) Drugs for GULP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GULP1: view

Transcripts for GULP1 Gene

Unigene Clusters for GULP1 Gene

GULP, engulfment adaptor PTB domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GULP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5:
SP6:
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - - -
SP13: - - - - -
SP14: - - - -
SP15: - -
SP16:
SP17: - - - - - - -

ExUns: 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d · 22e
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for GULP1 Gene

GeneLoc Exon Structure for
GULP1
ECgene alternative splicing isoforms for
GULP1

Expression for GULP1 Gene

mRNA expression in normal human tissues for GULP1 Gene

Protein differential expression in normal tissues from HIPED for GULP1 Gene

This gene is overexpressed in Plasma (25.9) and Placenta (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GULP1 Gene



SOURCE GeneReport for Unigene cluster for GULP1 Gene Hs.470887

mRNA Expression by UniProt/SwissProt for GULP1 Gene

Q9UBP9-GULP1_HUMAN
Tissue specificity: Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
genes like me logo Genes that share expression patterns with GULP1: view

Protein tissue co-expression partners for GULP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GULP1 Gene

Orthologs for GULP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GULP1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gulp1 35
  • 89.69 (n)
  • 92.43 (a)
Gulp1 16
Gulp1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GULP1 35
  • 99.78 (n)
  • 100 (a)
GULP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gulp1 35
  • 89.69 (n)
  • 92.43 (a)
cow
(Bos Taurus)
Mammalia GULP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GULP1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GULP1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GULP1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves GULP1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GULP1 36
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gulp1a 35
  • 74.78 (n)
  • 85 (a)
gulp1a 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ced-6 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ced-6 35
  • 51.87 (n)
  • 44.4 (a)
ced-6 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for GULP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GULP1 Gene

ENSEMBL:
Gene Tree for GULP1 (if available)
TreeFam:
Gene Tree for GULP1 (if available)

Paralogs for GULP1 Gene

Paralogs for GULP1 Gene

genes like me logo Genes that share paralogs with GULP1: view

Variants for GULP1 Gene

Sequence variations from dbSNP and Humsavar for GULP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs8273 -- 188,595,826(+) ATTTA(C/T)TTCTC nc-transcript-variant, utr-variant-3-prime
rs1077658 -- 188,292,853(-) CACCC(C/G)CGCCG intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1125099 -- 188,433,801(+) CAGGA(A/G)GTCCT intron-variant
rs1507551 -- 188,589,140(-) AAAAC(C/T)ATAAG intron-variant, utr-variant-3-prime
rs1507552 -- 188,571,918(+) ACCTT(C/T)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GULP1 Gene

Variant ID Type Subtype PubMed ID
esv267494 CNV Insertion 20981092
esv272454 CNV Insertion 20981092
esv2721252 CNV Deletion 23290073
esv275130 CNV Gain+Loss 21479260
nsv524228 CNV Gain 19592680
esv273105 CNV Insertion 20981092
esv269314 CNV Insertion 20981092
dgv750e199 CNV Deletion 23128226
esv27753 CNV Loss 19812545
esv274925 CNV Gain+Loss 21479260
nsv834489 CNV Gain 17160897
esv8987 CNV Gain 19470904

Variation tolerance for GULP1 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GULP1 Gene

HapMap Linkage Disequilibrium report
GULP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GULP1 Gene

Disorders for GULP1 Gene

Relevant External Links for GULP1

Genetic Association Database (GAD)
GULP1
Human Genome Epidemiology (HuGE) Navigator
GULP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GULP1

No disorders were found for GULP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GULP1 Gene

Publications for GULP1 Gene

  1. Apoptotic engulfment pathway and schizophrenia. (PMID: 19721717) Chen X. … Kendler K.S. (PLoS ONE 2009) 3 48 67
  2. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). (PMID: 11729193) Su H.P. … Ravichandran K.S. (J. Biol. Chem. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1). (PMID: 23167255) Wahler A. … von Arnim C.A. (Biochem. J. 2013) 3
  5. Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-I^ precursor protein. (PMID: 20674096) Beyer A.S. … von Arnim C.A. (Neurobiol. Aging 2012) 3

Products for GULP1 Gene

Sources for GULP1 Gene

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