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Aliases for GULOP Gene

Aliases for GULOP Gene

  • Gulonolactone (L-) Oxidase, Pseudogene 2 3 5
  • SCURVY 3
  • GULO 3

External Ids for GULOP Gene

Previous GeneCards Identifiers for GULOP Gene

  • GC08U990039
  • GC08P027255
  • GC08P027457
  • GC08P027491
  • GC08P027418

Summaries for GULOP Gene

Entrez Gene Summary for GULOP Gene

  • This gene is nonfunctional in humans and other primates. In most mammalian species the corresponding gene encodes L-gulono-gamma-lactone oxidase which catalyzes the last step of ascorbic acid biosynthesis. The human gene is a remnant that lacks five of twelve exons found in functional rodent genes. The loss of enzyme activity results in hypoascorbemia or the inability to synthesize vitamin C. [provided by RefSeq, Nov 2010]

GeneCards Summary for GULOP Gene

GULOP (Gulonolactone (L-) Oxidase, Pseudogene) is a Pseudogene. Diseases associated with GULOP include Scurvy.

Gene Wiki entry for GULOP Gene

Additional gene information for GULOP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GULOP Gene

Genomics for GULOP Gene

Regulatory Elements for GULOP Gene

Enhancers for GULOP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H027602 1.3 ENCODE dbSUPER 6.9 +43.1 43114 2 FOXA2 MLX ARID4B FEZF1 ZNF2 YY1 ZNF302 ZNF143 SP5 MXD4 CCDC25 ENSG00000253875 LOC100130612 LOC100132229 EPHX2 CHRNA2 ELP3 ESCO2 RNU6-1276P GULOP
GH08H027592 1.5 Ensembl ENCODE dbSUPER 5.5 +32.2 32216 0 HDGF ATF1 ARID4B ZNF2 YY1 ZNF121 CBX5 ZNF143 ATF7 DEK GULOP MIR6843
GH08H027610 1.6 Ensembl ENCODE dbSUPER 4.9 +53.8 53802 8 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FZD3 ZNF395 SCARA3 CLU GULOP MIR6843
GH08H027600 1.1 ENCODE dbSUPER 7 +40.3 40305 0 HDAC1 TBP FOXA2 PKNOX1 RAD21 YY1 TCF12 GATA2 POLR3A ATF7 ELP3 EPHX2 CHRNA2 GULOP MIR6843
GH08H027583 1.2 ENCODE dbSUPER 5.6 +24.1 24095 2 PKNOX1 ARID4B FEZF1 DMAP1 YY1 MXD4 TSHZ1 REST MIER2 PPARG CHRNA2 GULOP MIR6843
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GULOP on UCSC Golden Path with GeneCards custom track

Genomic Location for GULOP Gene

Chromosome:
8
Start:
27,560,274 bp from pter
End:
27,589,073 bp from pter
Size:
28,800 bases
Orientation:
Plus strand

Genomic View for GULOP Gene

Genes around GULOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GULOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GULOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GULOP Gene

Proteins for GULOP Gene

Post-translational modifications for GULOP Gene

No Post-translational modifications

No data available for DME Specific Peptides for GULOP Gene

Domains & Families for GULOP Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GULOP Gene

Function for GULOP Gene

Molecular function for GULOP Gene

GENATLAS Biochemistry:
gulono-gamma oxidase,non functional

Phenotypes From GWAS Catalog for GULOP Gene

Phenotypes for GULOP Gene

GenomeRNAi human phenotypes for GULOP:
genes like me logo Genes that share phenotypes with GULOP: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for GULOP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GULOP Gene

Localization for GULOP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GULOP Gene

Pathways & Interactions for GULOP Gene

SuperPathways for GULOP Gene

No Data Available

Interacting Proteins for GULOP Gene

Gene Ontology (GO) - Biological Process for GULOP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GULOP Gene

Drugs & Compounds for GULOP Gene

No Compound Related Data Available

Transcripts for GULOP Gene

mRNA/cDNA for GULOP Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for GULOP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GULOP Gene

No ASD Table

Relevant External Links for GULOP Gene

GeneLoc Exon Structure for
GULOP
ECgene alternative splicing isoforms for
GULOP

Expression for GULOP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GULOP Gene

mRNA differential expression in normal tissues according to GTEx for GULOP Gene

This gene is overexpressed in Pancreas (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of GULOP Gene:

GULOP
genes like me logo Genes that share expression patterns with GULOP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GULOP Gene

Orthologs for GULOP Gene

Evolution for GULOP Gene

ENSEMBL:
Gene Tree for GULOP (if available)
TreeFam:
Gene Tree for GULOP (if available)

No data available for Orthologs for GULOP Gene

Paralogs for GULOP Gene

No data available for Paralogs for GULOP Gene

Variants for GULOP Gene

Relevant External Links for GULOP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GULOP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for GULOP Gene

Disorders for GULOP Gene

MalaCards: The human disease database

(1) MalaCards diseases for GULOP Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
scurvy
  • deficiency of vitamin c
- elite association - COSMIC cancer census association via MalaCards
Search GULOP in MalaCards View complete list of genes associated with diseases

Relevant External Links for GULOP

Genetic Association Database (GAD)
GULOP
genes like me logo Genes that share disorders with GULOP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GULOP Gene

Publications for GULOP Gene

  1. Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man. (PMID: 8175804) Nishikimi M … Yagi K (The Journal of biological chemistry 1994) 2 3 60
  2. Occurrence in humans and guinea pigs of the gene related to their missing enzyme L-gulono-gamma-lactone oxidase. (PMID: 3214183) Nishikimi M … Yagi K (Archives of biochemistry and biophysics 1988) 2 3 60
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 60
  4. Conserved or lost: molecular evolution of the key gene GULO in vertebrate vitamin C biosynthesis. (PMID: 23404229) Yang H (Biochemical genetics 2013) 3 60
  5. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang ZD … Gerstein M (Genome biology 2010) 3 60

Products for GULOP Gene

Sources for GULOP Gene

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