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Aliases for GULOP Gene

Aliases for GULOP Gene

  • Gulonolactone (L-) Oxidase, Pseudogene 2 3
  • SCURVY 3
  • GULO 3

External Ids for GULOP Gene

Previous GeneCards Identifiers for GULOP Gene

  • GC08U990039
  • GC08P027255
  • GC08P027457
  • GC08P027491
  • GC08P027418

Summaries for GULOP Gene

Entrez Gene Summary for GULOP Gene

  • This gene is nonfunctional in humans and other primates. In most mammalian species the corresponding gene encodes L-gulono-gamma-lactone oxidase which catalyzes the last step of ascorbic acid biosynthesis. The human gene is a remnant that lacks five of twelve exons found in functional rodent genes. The loss of enzyme activity results in hypoascorbemia or the inability to synthesize vitamin C. [provided by RefSeq, Nov 2010]

GeneCards Summary for GULOP Gene

GULOP (Gulonolactone (L-) Oxidase, Pseudogene) is a Pseudogene. Diseases associated with GULOP include scurvy.

Gene Wiki entry for GULOP Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GULOP Gene

Genomics for GULOP Gene

Genomic Location for GULOP Gene

27,560,274 bp from pter
27,589,073 bp from pter
28,800 bases
Plus strand

Genomic View for GULOP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GULOP Gene

No data available for Regulatory Elements for GULOP Gene

Proteins for GULOP Gene

Post-translational modifications for GULOP Gene

No Post-translational modifications

No data available for DME Specific Peptides for GULOP Gene

Domains & Families for GULOP Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GULOP Gene

Function for GULOP Gene

Molecular function for GULOP Gene

GENATLAS Biochemistry:
gulono-gamma oxidase,non functional
genes like me logo Genes that share phenotypes with GULOP: view

Animal Models for GULOP Gene

MGI Knock Outs for GULOP:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for GULOP Gene

Localization for GULOP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GULOP Gene

Pathways & Interactions for GULOP Gene

SuperPathways for GULOP Gene

No Data Available

Interacting Proteins for GULOP Gene

Gene Ontology (GO) - Biological Process for GULOP Gene


No data available for Pathways by source and SIGNOR curated interactions for GULOP Gene

Drugs & Compounds for GULOP Gene

No Compound Related Data Available

Transcripts for GULOP Gene

mRNA/cDNA for GULOP Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GULOP Gene

No ASD Table

Relevant External Links for GULOP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GULOP Gene

mRNA expression in normal human tissues for GULOP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GULOP Gene

This gene is overexpressed in Pancreas (x5.2).
genes like me logo Genes that share expression patterns with GULOP: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GULOP Gene

Orthologs for GULOP Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for GULOP Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Gulo 16
Species with no ortholog for GULOP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GULOP Gene

Gene Tree for GULOP (if available)
Gene Tree for GULOP (if available)

Paralogs for GULOP Gene

No data available for Paralogs for GULOP Gene

Variants for GULOP Gene

Relevant External Links for GULOP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for GULOP Gene

Disorders for GULOP Gene

MalaCards: The human disease database

(1) MalaCards diseases for GULOP Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
  • deficiency of vitamin c
- elite association
Search GULOP in MalaCards View complete list of genes associated with diseases

Relevant External Links for GULOP

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with GULOP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GULOP Gene

Publications for GULOP Gene

  1. Restoration of vitamin C synthesis in transgenic Gulo-/- mice by helper-dependent adenovirus-based expression of gulonolactone oxidase. (PMID: 18764764) Li Y. … Schellhorn H.E. (Hum. Gene Ther. 2008) 23 67
  2. Can ageing-related degenerative diseases be ameliorated through administration of vitamin C at pharmacological levels? (PMID: 17141419) Li Y. … Schellhorn H.E. (Med. Hypotheses 2007) 23 67
  3. The L-gulono-gamma-lactone oxidase gene (GULO) which is a candidate for vitamin C deficiency in pigs maps to chromosome 14. (PMID: 10467707) Hasan L. … Stranzinger G. (Anim. Genet. 1999) 23 67
  4. Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man. (PMID: 8175804) Nishikimi M. … Yagi K. (J. Biol. Chem. 1994) 2 67
  5. Occurrence in humans and guinea pigs of the gene related to their missing enzyme L-gulono-gamma-lactone oxidase. (PMID: 3214183) Nishikimi M. … Yagi K. (Arch. Biochem. Biophys. 1988) 2 67

Products for GULOP Gene

Sources for GULOP Gene

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