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Aliases for GUK1 Gene

Aliases for GUK1 Gene

  • Guanylate Kinase 1 2 3 5
  • GMP Kinase 3 4
  • EC 2.7.4.8 4 61
  • GMK 3 4
  • ATP:GMP Phosphotransferase 3
  • Guanylate Kinase 3

External Ids for GUK1 Gene

Previous GeneCards Identifiers for GUK1 Gene

  • GC01P226825
  • GC01P224066
  • GC01P224713
  • GC01P225302
  • GC01P224634
  • GC01P226394
  • GC01P228327
  • GC01P198842

Summaries for GUK1 Gene

Entrez Gene Summary for GUK1 Gene

  • The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for GUK1 Gene

GUK1 (Guanylate Kinase 1) is a Protein Coding gene. Diseases associated with GUK1 include Retinitis Pigmentosa. Among its related pathways are Abacavir Pathway, Pharmacokinetics/Pharmacodynamics and purine nucleotides de novo biosynthesis. GO annotations related to this gene include guanylate kinase activity. An important paralog of this gene is LRRC23.

UniProtKB/Swiss-Prot for GUK1 Gene

  • Essential for recycling GMP and indirectly, cGMP.

Gene Wiki entry for GUK1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUK1 Gene

Genomics for GUK1 Gene

Regulatory Elements for GUK1 Gene

Enhancers for GUK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G228178 1.2 Ensembl ENCODE 5.9 +39.4 39357 1.8 PKNOX1 ATF1 ARNT AGO1 TCF12 ZNF121 GLIS2 GATA2 NCOA1 MBD2 OBSCN GUK1 GC01P228181 PIR60130 PIR41583
GH01G228137 1.4 ENCODE dbSUPER 0.7 +2.4 2422 8.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 OBSCN CICP26 ENSG00000269890 OBSCN-AS1 FAM96AP2 MRPL55 C1orf35 ENSG00000231563 RPL23AP15 HIST3H2A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GUK1 on UCSC Golden Path with GeneCards custom track

Promoters for GUK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021267 857 2201 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207

Genomic Location for GUK1 Gene

Chromosome:
1
Start:
228,139,643 bp from pter
End:
228,148,984 bp from pter
Size:
9,342 bases
Orientation:
Plus strand

Genomic View for GUK1 Gene

Genes around GUK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUK1 Gene

Proteins for GUK1 Gene

  • Protein details for GUK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16774-KGUA_HUMAN
    Recommended name:
    Guanylate kinase
    Protein Accession:
    Q16774
    Secondary Accessions:
    • B1ANH1

    Protein attributes for GUK1 Gene

    Size:
    197 amino acids
    Molecular mass:
    21726 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • In addition to phosphorylating GMP, antiviral prodrugs such as acyclovir, ganciclovir, and carbovir and anticancer prodrugs such as the thiopurines are dependent on GMPK for their activation.

    Alternative splice isoforms for GUK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GUK1 Gene

Selected DME Specific Peptides for GUK1 Gene

Q16774:
  • GDFIEHA
  • SGPSGAGK
  • GNLYGTS

Post-translational modifications for GUK1 Gene

  • Ubiquitination at isoforms=2, 351
  • Modification sites at PhosphoSitePlus

Domains & Families for GUK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16774

UniProtKB/Swiss-Prot:

KGUA_HUMAN :
  • Belongs to the guanylate kinase family.
Family:
  • Belongs to the guanylate kinase family.
genes like me logo Genes that share domains with GUK1: view

No data available for Gene Families for GUK1 Gene

Function for GUK1 Gene

Molecular function for GUK1 Gene

GENATLAS Biochemistry:
guanylate kinase 1
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + GMP = ADP + GDP.
UniProtKB/Swiss-Prot Function:
Essential for recycling GMP and indirectly, cGMP.

Enzyme Numbers (IUBMB) for GUK1 Gene

Gene Ontology (GO) - Molecular Function for GUK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004385 guanylate kinase activity EXP,IDA 8663313
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GUK1: view
genes like me logo Genes that share phenotypes with GUK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GUK1

CRISPR Products

miRNA for GUK1 Gene

miRTarBase miRNAs that target GUK1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GUK1 Gene

Localization for GUK1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GUK1 gene
Compartment Confidence
cytosol 5
mitochondrion 3
plasma membrane 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GUK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GUK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GUK1 Gene

Pathways & Interactions for GUK1 Gene

genes like me logo Genes that share pathways with GUK1: view

Gene Ontology (GO) - Biological Process for GUK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006163 purine nucleotide metabolic process IDA 8663313
GO:0006185 dGDP biosynthetic process IEA --
GO:0015949 nucleobase-containing small molecule interconversion TAS --
GO:0016310 phosphorylation IEA --
GO:0019673 GDP-mannose metabolic process IEA --
genes like me logo Genes that share ontologies with GUK1: view

No data available for SIGNOR curated interactions for GUK1 Gene

Drugs & Compounds for GUK1 Gene

(15) Drugs for GUK1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Guanosine monophosphate Experimental Pharma Target 0
2'-Deoxyguanosine-5'-Monophosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(13) Additional Compounds for GUK1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dGDP
  • 2'-Deoxy-GDP
  • 2'-Deoxyguanosine-5'-diphosphate
  • 5'-dGDP
  • Deoxyguanosine 5'-diphosphate
  • Deoxyguanosine diphosphate
3493-09-2
genes like me logo Genes that share compounds with GUK1: view

Transcripts for GUK1 Gene

Unigene Clusters for GUK1 Gene

Guanylate kinase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUK1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b · 8c ^ 9a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - -
SP15: - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - -
SP19: - - - - - - -
SP20: - - -
SP21: - -
SP22: - -
SP23: -
SP24: - - - - - - - - -
SP25: - - - - - - - - - -
SP26: - - - - - - - -
SP27:
SP28: - - - - - - -
SP29:
SP30:
SP31: - - - - - - - - -
SP32: - - - - - - - - -
SP33:

ExUns: 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g · 14h · 14i · 14j · 14k
SP1: -
SP2: -
SP3: -
SP4: -
SP5: - - -
SP6: -
SP7: -
SP8:
SP9: - - -
SP10:
SP11: - - - - -
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: - - -
SP23: -
SP24:
SP25:
SP26:
SP27: - -
SP28:
SP29:
SP30: -
SP31:
SP32:
SP33:

Relevant External Links for GUK1 Gene

GeneLoc Exon Structure for
GUK1
ECgene alternative splicing isoforms for
GUK1

Expression for GUK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GUK1 Gene

mRNA differential expression in normal tissues according to GTEx for GUK1 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for GUK1 Gene

This gene is overexpressed in Retina (9.9) and Oral epithelium (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GUK1 Gene



Protein tissue co-expression partners for GUK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GUK1 Gene:

GUK1

SOURCE GeneReport for Unigene cluster for GUK1 Gene:

Hs.376933

Evidence on tissue expression from TISSUES for GUK1 Gene

  • Lung(4.8)
  • Eye(4.7)
  • Nervous system(4.6)
  • Liver(4.3)
  • Skin(3.8)
  • Intestine(3.2)
  • Pancreas(3.1)
  • Kidney(3)
  • Bone marrow(2.2)
  • Adrenal gland(2)
  • Gall bladder(2)
  • Heart(2)
  • Lymph node(2)
  • Muscle(2)
  • Spleen(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with GUK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUK1 Gene

Orthologs for GUK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GUK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GUK1 34 35
  • 99.07 (n)
cow
(Bos Taurus)
Mammalia GUK1 34 35
  • 86.02 (n)
dog
(Canis familiaris)
Mammalia GUK1 34 35
  • 84.25 (n)
mouse
(Mus musculus)
Mammalia Guk1 34 16 35
  • 83 (n)
rat
(Rattus norvegicus)
Mammalia Guk1 34
  • 82.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GUK1 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves GUK1 34 35
  • 70.58 (n)
lizard
(Anolis carolinensis)
Reptilia GUK1 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia guk1 34
  • 67.01 (n)
LOC394964 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16484 34
zebrafish
(Danio rerio)
Actinopterygii guk1a 34 35
  • 69.43 (n)
guk1b 35
  • 53 (a)
OneToMany
zgc73128 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.779 34
fruit fly
(Drosophila melanogaster)
Insecta CG11811 36 34 35
  • 61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011105 34
  • 60.31 (n)
worm
(Caenorhabditis elegans)
Secernentea guk-1 34 35
  • 54.56 (n)
T03F1.8 36
  • 54 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER309W 34
  • 56.88 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01694g 34
  • 53.65 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUK1 34 35
  • 49.36 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AGK2 34
  • 51.01 (n)
rice
(Oryza sativa)
Liliopsida Os12g0515600 34
  • 51.45 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06300 34
  • 58.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6777 35
  • 56 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1198.05 34
  • 52.06 (n)
Species where no ortholog for GUK1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUK1 Gene

ENSEMBL:
Gene Tree for GUK1 (if available)
TreeFam:
Gene Tree for GUK1 (if available)

Paralogs for GUK1 Gene

Paralogs for GUK1 Gene

genes like me logo Genes that share paralogs with GUK1: view

Variants for GUK1 Gene

Sequence variations from dbSNP and Humsavar for GUK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000132222 -- 228,137,997(+) CCCAA(C/T)AGACC upstream-variant-2KB
rs1000547808 -- 228,149,365(+) ATGCC(C/T)CTCCC downstream-variant-500B, upstream-variant-2KB
rs1000698950 -- 228,145,365(+) AAGAA(C/T)ACCCA intron-variant
rs1000806904 -- 228,147,317(+) AGAAC(A/G)CTGGG intron-variant
rs1001174678 -- 228,146,221(+) TCAAT(C/T)AGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GUK1 Gene

Variant ID Type Subtype PubMed ID
dgv839n54 CNV loss 21841781
esv32853 CNV gain 17666407
nsv1160102 CNV deletion 26073780
nsv523935 CNV loss 19592680
nsv549290 CNV loss 21841781
nsv826908 CNV gain 20364138
nsv827019 CNV loss 20364138
nsv952137 CNV deletion 24416366

Variation tolerance for GUK1 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GUK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUK1 Gene

Disorders for GUK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GUK1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search GUK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GUK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GUK1
genes like me logo Genes that share disorders with GUK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUK1 Gene

Publications for GUK1 Gene

  1. Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation. (PMID: 8647247) Fitzgibbon J. … Hunt D.M. (FEBS Lett. 1996) 2 3 4 22 64
  2. Cloning, characterization, and modeling of mouse and human guanylate kinases. (PMID: 8663313) Brady W.A. … Black M.E. (J. Biol. Chem. 1996) 3 4 22 64
  3. Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas. (PMID: 16832584) da Rocha A.A. … Giannella-Neto D. (Pituitary 2006) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64

Products for GUK1 Gene

  • Addgene plasmids for GUK1

Sources for GUK1 Gene

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