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Aliases for GUK1 Gene

Aliases for GUK1 Gene

  • Guanylate Kinase 1 2 3 5
  • GMP Kinase 3 4
  • EC 2.7.4.8 4 63
  • GMK 3 4
  • ATP:GMP Phosphotransferase 3

External Ids for GUK1 Gene

Previous GeneCards Identifiers for GUK1 Gene

  • GC01P226825
  • GC01P224066
  • GC01P224713
  • GC01P225302
  • GC01P224634
  • GC01P226394
  • GC01P228327
  • GC01P198842

Summaries for GUK1 Gene

Entrez Gene Summary for GUK1 Gene

  • The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for GUK1 Gene

GUK1 (Guanylate Kinase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Abacavir transport and metabolism. GO annotations related to this gene include guanylate kinase activity. An important paralog of this gene is LRRC23.

UniProtKB/Swiss-Prot for GUK1 Gene

  • Essential for recycling GMP and indirectly, cGMP.

Gene Wiki entry for GUK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUK1 Gene

Genomics for GUK1 Gene

Regulatory Elements for GUK1 Gene

Promoters for GUK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GUK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GUK1 Gene

Chromosome:
1
Start:
228,139,643 bp from pter
End:
228,148,984 bp from pter
Size:
9,342 bases
Orientation:
Plus strand

Genomic View for GUK1 Gene

Genes around GUK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUK1 Gene

Proteins for GUK1 Gene

  • Protein details for GUK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16774-KGUA_HUMAN
    Recommended name:
    Guanylate kinase
    Protein Accession:
    Q16774
    Secondary Accessions:
    • B1ANH1

    Protein attributes for GUK1 Gene

    Size:
    197 amino acids
    Molecular mass:
    21726 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • In addition to phosphorylating GMP, antiviral prodrugs such as acyclovir, ganciclovir, and carbovir and anticancer prodrugs such as the thiopurines are dependent on GMPK for their activation.

    Alternative splice isoforms for GUK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GUK1 Gene

Proteomics data for GUK1 Gene at MOPED

Selected DME Specific Peptides for GUK1 Gene

Post-translational modifications for GUK1 Gene

  • Ubiquitination at Lys 51
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for GUK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16774

UniProtKB/Swiss-Prot:

KGUA_HUMAN :
  • Contains 1 guanylate kinase-like domain.
  • Belongs to the guanylate kinase family.
Domain:
  • Contains 1 guanylate kinase-like domain.
Family:
  • Belongs to the guanylate kinase family.
genes like me logo Genes that share domains with GUK1: view

No data available for Gene Families for GUK1 Gene

Function for GUK1 Gene

Molecular function for GUK1 Gene

GENATLAS Biochemistry:
guanylate kinase 1
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + GMP = ADP + GDP.
UniProtKB/Swiss-Prot Function:
Essential for recycling GMP and indirectly, cGMP.

Enzyme Numbers (IUBMB) for GUK1 Gene

genes like me logo Genes that share phenotypes with GUK1: view

Animal Model Products

miRNA for GUK1 Gene

miRTarBase miRNAs that target GUK1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GUK1 Gene

Localization for GUK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GUK1 Gene COMPARTMENTS Subcellular localization image for GUK1 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 2
plasma membrane 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GUK1 Gene

Pathways & Interactions for GUK1 Gene

genes like me logo Genes that share pathways with GUK1: view

Gene Ontology (GO) - Biological Process for GUK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006163 purine nucleotide metabolic process IEA,IDA 8663313
GO:0015949 nucleobase-containing small molecule interconversion TAS --
GO:0017144 drug metabolic process TAS --
GO:0019673 GDP-mannose metabolic process IEA --
GO:0034436 glycoprotein transport IEA --
genes like me logo Genes that share ontologies with GUK1: view

No data available for SIGNOR curated interactions for GUK1 Gene

Drugs & Compounds for GUK1 Gene

(16) Drugs for GUK1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Guanosine monophosphate Experimental Pharma Target 0
2'-Deoxyguanosine-5'-Monophosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(12) Additional Compounds for GUK1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dGDP
  • 2'-Deoxy-GDP
  • 2'-Deoxyguanosine-5'-diphosphate
  • 5'-dGDP
  • Deoxyguanosine 5'-diphosphate
  • Deoxyguanosine diphosphate
3493-09-2
genes like me logo Genes that share compounds with GUK1: view

Transcripts for GUK1 Gene

Unigene Clusters for GUK1 Gene

Guanylate kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GUK1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b · 8c ^ 9a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - -
SP15: - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - -
SP19: - - - - - - -
SP20: - - -
SP21: - -
SP22: - -
SP23: -
SP24: - - - - - - - - -
SP25: - - - - - - - - - -
SP26: - - - - - - - -
SP27:
SP28: - - - - - - -
SP29:
SP30:
SP31: - - - - - - - - -
SP32: - - - - - - - - -
SP33:

ExUns: 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g · 14h · 14i · 14j · 14k
SP1: -
SP2: -
SP3: -
SP4: -
SP5: - - -
SP6: -
SP7: -
SP8:
SP9: - - -
SP10:
SP11: - - - - -
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: - - -
SP23: -
SP24:
SP25:
SP26:
SP27: - -
SP28:
SP29:
SP30: -
SP31:
SP32:
SP33:

Relevant External Links for GUK1 Gene

GeneLoc Exon Structure for
GUK1
ECgene alternative splicing isoforms for
GUK1

Expression for GUK1 Gene

mRNA expression in normal human tissues for GUK1 Gene

mRNA differential expression in normal tissues according to GTEx for GUK1 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for GUK1 Gene

This gene is overexpressed in Retina (9.9) and Oral epithelium (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GUK1 Gene



SOURCE GeneReport for Unigene cluster for GUK1 Gene Hs.376933

genes like me logo Genes that share expression patterns with GUK1: view

Protein tissue co-expression partners for GUK1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GUK1 Gene

Orthologs for GUK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GUK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GUK1 35
  • 86.02 (n)
  • 90.78 (a)
GUK1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GUK1 35
  • 84.25 (n)
  • 89.45 (a)
GUK1 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Guk1 35
  • 83 (n)
  • 88.38 (a)
Guk1 16
Guk1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GUK1 35
  • 99.07 (n)
  • 99.44 (a)
GUK1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Guk1 35
  • 82.23 (n)
  • 87.31 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GUK1 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves GUK1 35
  • 70.58 (n)
  • 73.98 (a)
GUK1 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GUK1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia guk1 35
  • 67.01 (n)
  • 68.88 (a)
LOC394964 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16484 35
zebrafish
(Danio rerio)
Actinopterygii guk1a 35
  • 69.43 (n)
  • 74.09 (a)
zgc73128 35
guk1a 36
  • 59 (a)
OneToMany
guk1b 36
  • 53 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.779 35
fruit fly
(Drosophila melanogaster)
Insecta CG11811 37
  • 56 (a)
CG11811 35
  • 61 (n)
  • 56.19 (a)
CG11811 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011105 35
  • 60.31 (n)
  • 55.67 (a)
worm
(Caenorhabditis elegans)
Secernentea T03F1.8 37
  • 54 (a)
guk-1 35
  • 54.56 (n)
  • 55.26 (a)
guk-1 36
  • 44 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER309W 35
  • 56.88 (n)
  • 56.52 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01694g 35
  • 53.65 (n)
  • 52.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUK1 35
  • 49.36 (n)
  • 51.91 (a)
GUK1 36
  • 43 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AGK2 35
  • 51.01 (n)
  • 48.62 (a)
rice
(Oryza sativa)
Liliopsida Os12g0515600 35
  • 51.45 (n)
  • 48.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06300 35
  • 58.24 (n)
  • 47.75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1198.05 35
  • 52.06 (n)
  • 52.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6777 36
  • 56 (a)
OneToOne
Species with no ortholog for GUK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUK1 Gene

ENSEMBL:
Gene Tree for GUK1 (if available)
TreeFam:
Gene Tree for GUK1 (if available)

Paralogs for GUK1 Gene

Paralogs for GUK1 Gene

genes like me logo Genes that share paralogs with GUK1: view

Variants for GUK1 Gene

Sequence variations from dbSNP and Humsavar for GUK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs15112 -- 228,145,596(+) GAGCA(A/C)AGCGG reference, missense
rs15113 -- 228,141,191(+) TCTTT(C/T)TCCCT intron-variant, utr-variant-5-prime
rs947086 -- 228,141,042(-) ATGCA(A/G)AGACG intron-variant
rs1105447 -- 228,140,782(+) TATTC(C/T)GGGGC intron-variant
rs1803695 -- 228,147,424(+) CAGGC(C/T)GTGCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GUK1 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv523935 CNV Loss 19592680
nsv873252 CNV Loss 21882294
dgv537n71 CNV Loss 21882294
nsv873255 CNV Loss 21882294
nsv827019 CNV Loss 20364138
nsv873256 CNV Loss 21882294
nsv873257 CNV Loss 21882294
dgv538n71 CNV Loss 21882294
dgv539n71 CNV Loss 21882294

Variation tolerance for GUK1 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUK1 Gene

HapMap Linkage Disequilibrium report
GUK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUK1 Gene

Disorders for GUK1 Gene

Relevant External Links for GUK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GUK1

No disorders were found for GUK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GUK1 Gene

Publications for GUK1 Gene

  1. Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation. (PMID: 8647247) Fitzgibbon J. … Hunt D.M. (FEBS Lett. 1996) 2 3 4 23 67
  2. Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas. (PMID: 16832584) da Rocha A.A. … Giannella-Neto D. (Pituitary 2006) 3 23
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26

Products for GUK1 Gene

Sources for GUK1 Gene

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