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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GUCY2F Gene

protein-coding   GIFtS: 62
GCID: GC0XM108616

Guanylate Cyclase 2F, Retinal

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Guanylate Cyclase 2F, Retinal1 2 3     Guanylate Cyclase 2D-Like1
GUC2F2 3 5     Membrane (Retina-Specific)1
Guanylate Cyclase F2 3     CYGF2
Rod Outer Segment Membrane Guanylate Cyclase 22 3     GUC2DL2
GC-F2 3     Guanylate Cyclase 2D-Like, Membrane (Retina-Specific)2
RETGC-22 3     Retinal Guanylyl Cyclase 22
ROS-GC22 3     RETGC23
EC 4.6.1.23 8     EC 4.6.18

External Ids:    HGNC: 46911   Entrez Gene: 29862   Ensembl: ENSG000001018907   OMIM: 3000415   UniProtKB: P518413   

Export aliases for GUCY2F gene to outside databases

Previous GC identifers: GC0XM103919 GC0XM105762 GC0XM106641 GC0XM107380 GC0XM108422 GC0XM098238


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GUCY2F Gene:
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The
encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal
transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein.
Defects in this gene may be a cause of X-linked retinitis pigmentosa. (provided by RefSeq, Dec 2008)

GeneCards Summary for GUCY2F Gene: 
GUCY2F (guanylate cyclase 2F, retinal) is a protein-coding gene. Diseases associated with GUCY2F include retinitis, and retinal disease, and among its related super-pathways are The phototransduction cascade and Retinoid metabolism and transport. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: GUC2F_HUMAN, P51841
Function: Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the
enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GUCY2F gene promoter:
         Pax-6   Lmo2   Nkx2-5   POU6F1 (c2)   STAT5A   HNF-4alpha1   Evi-1   RORalpha1   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGUCY2F promoter sequence
   Search SABiosciences Chromatin IP Primers for GUCY2F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GUCY2F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq22

GUCY2F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GUCY2F gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM108616:  view genomic region     (about GC identifiers)

Start:
108,616,135 bp from pter      End:
108,725,301 bp from pter
Size:
109,167 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GUC2F_HUMAN, P51841 (See protein sequence)
Recommended Name: Retinal guanylyl cyclase 2 precursor  
Size: 1108 amino acids; 124850 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9UJF1

Explore the universe of human proteins at neXtProt for GUCY2F: NX_P51841

Explore proteomics data for GUCY2F at MOPED 

Post-translational modifications:

  • UniProtKB: There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be
    involved in intra- or interchain disulfide bonds
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51841

  • 4/28 DME Specific Peptides for GUCY2F (P51841) (see all 28)
     ERTEELE  ASRMEST  SEPIEVV  LLNDLYT 

    GUCY2F Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GUCY2F Protein Expression
    REFSEQ proteins: NP_001513.2  
    ENSEMBL proteins: 
     ENSP00000218006  
    Reactome Protein details: P51841
    Human Recombinant Protein Products for GUCY2F: 
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    Cloud-Clone Corp. Proteins for GUCY2F 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005640nuclear outer membrane TAS7777544
    GO:0005887integral to plasma membrane TAS7777544
    GO:0016020membrane ----
    GO:0097381photoreceptor disc membrane TAS--

    GUCY2F for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR011645 Haem_no_assoc-bd
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry P51841

    ProtoNet protein and cluster: P51841

    1 Blocks protein domain: IPB001828 Extracellular ligand-binding receptor

    UniProtKB/Swiss-Prot: GUC2F_HUMAN, P51841
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 1 guanylate cyclase domain
    Similarity: Contains 1 protein kinase domain


    GUCY2F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GUC2F_HUMAN, P51841
    Function: Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the
    enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction
    Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate
    Enzyme regulation: Activated by GCAP-1; inhibited by calcium

         Genatlas biochemistry entry for GUCY2F:
    guanylate cyclase 2F,membrane form expressed in the retina,homolog to murine Gucyf

         Enzyme Numbers (IUBMB): EC 4.6.1.21 2 EC 4.6.12

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004383guanylate cyclase activity IEA--
    GO:0004672protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004872receptor activity TAS7777544
    GO:0005515protein binding ----
         
    GUCY2F for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GUCY2F:
     Decreased substrate adherent c 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gucy2f):
     nervous system  vision/eye 

    GUCY2F for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gucy2ftm1Wbae for GUCY2F

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GUCY2F 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GUCY2F About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Visual signal transduction- Rods
    Visual signal transduction- Rods0.54
    Phototransduction0.46
    The phototransduction cascade0.54
    Visual signal transduction- Cones0.39
    Inactivation, recovery and regulation of the phototransduction cascade0.51
    2Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    3G-Beta Gamma Signaling
    CRHR Pathway0.44
    Relaxin Pathway0.37
    4Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GUCY2F (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Relaxin Pathway
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CRHR Pathway

    2 BioSystems Pathways for GUCY2F
        Visual signal transduction- Rods
    Visual signal transduction- Cones

    5/6        Reactome Pathways for GUCY2F (see all 6)
        Diseases associated with visual transduction
    The phototransduction cascade
    Signal Transduction
    Visual phototransduction
    Disease


    2         Kegg Pathways  (Kegg details for GUCY2F):
        Purine metabolism
    Phototransduction


    GUCY2F for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GUCY2F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for GUCY2F (P518412, 3 ENSP000002180064) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GUCA1BQ9UMX63, ENSP000002303614I2D: score=1 STRING: ENSP00000230361
    GUCA1AENSP000000534694STRING: ENSP00000053469
    GUCA1CENSP000002610474STRING: ENSP00000261047
    PDE11AENSP000002860634STRING: ENSP00000286063
    PDE4AENSP000002704744STRING: ENSP00000270474
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006182cGMP biosynthetic process ----
    GO:0006468protein phosphorylation ----
    GO:0007168receptor guanylyl cyclase signaling pathway TAS7777544
    GO:0007601visual perception IEA--
    GO:0007603phototransduction, visible light TAS--

    GUCY2F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GUCY2F for compounds           About GeneDecksing

    EMD Millipore small molecules for GUCY2F:
    Small Molecule - inhibitor
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    Browse Tocris compounds for GUCY2F (GUC2F)

    5 HMDB Compounds for GUCY2F    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    3 Novoseek inferred chemical compound relationships for GUCY2F gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 71.4 3 9439621 (1), 11952100 (1), 19941038 (1)
    cgmp 55.9 1 9698373 (1)
    calcium 25 2 7777544 (1), 9879655 (1)

    Search CenterWatch for drugs/clinical trials and news about GUCY2F / GUC2F

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GUCY2F gene: 
    NM_001522.2  

    Unigene Cluster for GUCY2F:

    Guanylate cyclase 2F, retinal
    Hs.123074  [show with all ESTs]
    Unigene Representative Sequence: L37378
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000218006(uc011msq.2 uc022cch.1 uc004eod.4)
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    Additional mRNA sequence: 

    BC144241.1 L37378.1 

    1 DOTS entry:

    DT.104356 

    5 AceView cDNA sequences:

    BV194121 BV198908 NM_001522 L37378 BX954134 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GUCY2F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GUCY2F Expression
    About this image


    See GUCY2F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GUCY2F

    SOURCE GeneReport for Unigene cluster: Hs.123074

    UniProtKB/Swiss-Prot: GUC2F_HUMAN, P51841
    Tissue specificity: Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and
    cone photoreceptor cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GUCY2F gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gucy2f1 , 5 guanylate cyclase 2f1, 5 89.05(n)1
    89.89(a)1
      X (62.85 cM)5
    2456501  NM_001007576.21  NP_001007577.11 
     1420811605 
    chicken
    (Gallus gallus)
    Aves GUCY2F1 guanylate cyclase 2F, retinal 63.41(n)
    62.37(a)
      419089  XM_417281.2  XP_417281.2 
    lizard
    (Anolis carolinensis)
    Reptilia GUCY2F6
    Guanylate cyclase
    58(a)
    possible ortholog
    GL343493.1(343439-408757)
    zebrafish
    (Danio rerio)
    Actinopterygii gucy2f2 guanylate cyclase 2F, retinal 75.88(n)   140424  AY050503.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97833 receptor guanylate cyclase 56(a)
    (best of 4)
      82C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea gcy-223 Natriuretic peptides receptors,
    guanylate cyclase
    43(a)
    (best of 20)
      V(20812562-20817185)   --


    ENSEMBL Gene Tree for GUCY2F (if available)
    TreeFam Gene Tree for GUCY2F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GUCY2F gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY1A22  ADCY72  
    ADCY92  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    3 SIMAP similar genes for GUCY2F using alignment to 1 protein entry:     GUC2F_HUMAN:
    GUCY2D    NPR2    NPR1

    GUCY2F for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1500 SNPs in GUCY2F are shown (see all 1500)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0422434
    A lung squamous cell carcinoma sample4--see VAR_0422432 E D mis40--------
    VAR_0422384
    A glioblastoma multiforme sample4--see VAR_0422382 G D mis40--------
    VAR_0422424
    A lung adenocarcinoma sample4--see VAR_0422422 K R mis40--------
    VAR_0364194
    A breast cancer sample4--see VAR_0364192 R P mis40--------
    VAR_0694244
    ----see VAR_0694242 G D mis40--------
    rs1901065381,2
    --108595706(+) CTTAGC/GCTTCA 1 -- ds50010--------
    rs1811459611,2
    --108595762(+) CCTTAC/TGCATT 1 -- ds50010--------
    rs1855379111,2
    --108595776(+) GCCAAC/TTGAGG 1 -- ds50010--------
    rs2001379721,2
    C--108595823(+) AAGGC-/TTTTTT 1 -- ds50010--------
    rs1384361031,2
    --108595891(+) CTAGAG/TATTAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GUCY2F (108616135 - 108725301 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GUCY2F: --

    Locus Specific Mutation Databases (LSDB): GUCY2F
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GUCY2F
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300041    OMIM disorders: --

    8 diseases for GUCY2F:    About MalaCards
    retinitis    retinal disease    leber congenital amaurosis    retinitis pigmentosa
    pancreatic cancer    tuberculosis    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for GUCY2F:
    Leber congenital amaurosis

    GUCY2F for disorders           About GeneDecksing

    Genetic Association Database (GAD): GUCY2F
    Human Genome Epidemiology (HuGE) Navigator: GUCY2F (1 document)

    Export disorders for GUCY2F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GUCY2F gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with GUCY2F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2. (PubMed id 7777544)1, 2, 3, 9 Lowe D.G....Hurley J.B. (1995)
    2. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. (PubMed id 8838319)1, 3, 9 Yang R.B....Garbers D.L. (1996)
    3. Genetic mutations associated with cigarette smoking in pancreatic cancer. (PubMed id 19351817)1, 4 Blackford A....Hruban R.H. (2009)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    5. The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2. (PubMed id 9698373)1, 9 Laura R.P. and Hurley J.B. (1998)
    6. Diagnostic exome sequencing in persons with severe intellectual disability. (PubMed id 23033978)2 de Ligt J.... Vissers L.E. (2012)
    7. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    8. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    9. Expression level and activity profile of membrane bound guanylate cyclase type 2 in rod outer segments. (PubMed id 17868328)1 Helten A....Koch K.W. (2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2986 HGNC: 4691 AceView: GUCY2F Ensembl:ENSG00000101890 euGenes: HUgn2986
    ECgene: GUCY2F Kegg: 2986 H-InvDB: GUCY2F

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GUCY2F Pharmacogenomics, SNPs, Pathways
    Mutations of the GUCY2F genehttp://www.retina-international.org/files/sci-news/gcmut.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GUCY2F gene:
    Search GeneIP for patents involving GUCY2F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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