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Aliases for GUCY2F Gene

Aliases for GUCY2F Gene

  • Guanylate Cyclase 2F, Retinal 2 3 4
  • Rod Outer Segment Membrane Guanylate Cyclase 2 3 4
  • Guanylate Cyclase F 3 4
  • EC 4.6.1.2 4 63
  • RETGC-2 3 4
  • ROS-GC2 3 4
  • GUC2F 3 4
  • GC-F 3 4
  • Guanylate Cyclase 2D-Like, Membrane (Retina-Specific) 3
  • Membrane (Retina-Specific) 2
  • Guanylate Cyclase 2D-Like 2
  • EC 4.6.1 63
  • GUC2DL 3
  • RETGC2 4
  • CYGF 3

External Ids for GUCY2F Gene

Previous GeneCards Identifiers for GUCY2F Gene

  • GC0XM103919
  • GC0XM105762
  • GC0XM106641
  • GC0XM107380
  • GC0XM108422
  • GC0XM108616
  • GC0XM098238

Summaries for GUCY2F Gene

Entrez Gene Summary for GUCY2F Gene

  • The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]

GeneCards Summary for GUCY2F Gene

GUCY2F (Guanylate Cyclase 2F, Retinal) is a Protein Coding gene. Diseases associated with GUCY2F include leber congenital amaurosis and retinitis pigmentosa. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for GUCY2F Gene

  • Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY2F Gene

Genomics for GUCY2F Gene

Regulatory Elements for GUCY2F Gene

Genomic Location for GUCY2F Gene

Chromosome:
X
Start:
109,372,017 bp from pter
End:
109,482,072 bp from pter
Size:
110,056 bases
Orientation:
Minus strand

Genomic View for GUCY2F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GUCY2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY2F Gene

Proteins for GUCY2F Gene

  • Protein details for GUCY2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51841-GUC2F_HUMAN
    Recommended name:
    Retinal guanylyl cyclase 2
    Protein Accession:
    P51841
    Secondary Accessions:
    • Q9UJF1

    Protein attributes for GUCY2F Gene

    Size:
    1108 amino acids
    Molecular mass:
    124850 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GUCY2F Gene

Proteomics data for GUCY2F Gene at MOPED

Post-translational modifications for GUCY2F Gene

  • There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GUCY2F Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GUCY2F Gene

Gene Families for GUCY2F Gene

Suggested Antigen Peptide Sequences for GUCY2F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51841

UniProtKB/Swiss-Prot:

GUC2F_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 guanylate cyclase domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY2F: view

Function for GUCY2F Gene

Molecular function for GUCY2F Gene

GENATLAS Biochemistry:
guanylate cyclase 2F,membrane form expressed in the retina,homolog to murine Gucyf
UniProtKB/Swiss-Prot CatalyticActivity:
GTP = 3,5-cyclic GMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by GCAP-1; inhibited by calcium
UniProtKB/Swiss-Prot Function:
Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction

Enzyme Numbers (IUBMB) for GUCY2F Gene

Gene Ontology (GO) - Molecular Function for GUCY2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 NOT adenylate cyclase activity IBA --
GO:0004383 guanylate cyclase activity IEA --
GO:0004672 protein kinase activity IEA --
GO:0004872 receptor activity TAS 7777544
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GUCY2F: view
genes like me logo Genes that share phenotypes with GUCY2F: view

Animal Models for GUCY2F Gene

MGI Knock Outs for GUCY2F:

Animal Model Products

miRNA for GUCY2F Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCY2F

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for GUCY2F Gene

Localization for GUCY2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY2F Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GUCY2F Gene COMPARTMENTS Subcellular localization image for GUCY2F gene
Compartment Confidence
nucleus 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for GUCY2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005640 nuclear outer membrane TAS 7777544
GO:0005887 integral component of plasma membrane TAS 7777544
GO:0008074 guanylate cyclase complex, soluble IBA --
GO:0016020 membrane --
GO:0097381 photoreceptor disc membrane TAS --
genes like me logo Genes that share ontologies with GUCY2F: view

Pathways & Interactions for GUCY2F Gene

genes like me logo Genes that share pathways with GUCY2F: view

Gene Ontology (GO) - Biological Process for GUCY2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IBA --
GO:0006468 protein phosphorylation IEA --
GO:0007168 receptor guanylyl cyclase signaling pathway TAS 7777544
GO:0007601 visual perception TAS 7777544
GO:0007603 phototransduction, visible light TAS --
genes like me logo Genes that share ontologies with GUCY2F: view

No data available for SIGNOR curated interactions for GUCY2F Gene

Drugs & Compounds for GUCY2F Gene

(5) Drugs for GUCY2F Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclic GMP Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Calcium Nutra 0
cgmp Pharma Activation, Activator 0

(2) Additional Compounds for GUCY2F Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
guanylate
genes like me logo Genes that share compounds with GUCY2F: view

Transcripts for GUCY2F Gene

mRNA/cDNA for GUCY2F Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GUCY2F Gene

Guanylate cyclase 2F, retinal:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCY2F

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY2F Gene

No ASD Table

Relevant External Links for GUCY2F Gene

GeneLoc Exon Structure for
GUCY2F
ECgene alternative splicing isoforms for
GUCY2F

Expression for GUCY2F Gene

mRNA expression in normal human tissues for GUCY2F Gene

mRNA differential expression in normal tissues according to GTEx for GUCY2F Gene

This gene is overexpressed in Testis (x13.6) and Cervix - Endocervix (x5.9).

Protein differential expression in normal tissues from HIPED for GUCY2F Gene

This gene is overexpressed in Cervix (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GUCY2F Gene



SOURCE GeneReport for Unigene cluster for GUCY2F Gene Hs.123074

mRNA Expression by UniProt/SwissProt for GUCY2F Gene

P51841-GUC2F_HUMAN
Tissue specificity: Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells
genes like me logo Genes that share expression patterns with GUCY2F: view

Protein tissue co-expression partners for GUCY2F Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GUCY2F Gene

Orthologs for GUCY2F Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY2F Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GUCY2F 35
  • 91.26 (n)
  • 90.44 (a)
GUCY2F 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GUCY2F 35
  • 91.16 (n)
  • 91.34 (a)
GUCY2F 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gucy2f 35
  • 89.05 (n)
  • 89.89 (a)
Gucy2f 16
Gucy2f 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GUCY2F 35
  • 97.71 (n)
  • 97.12 (a)
GUCY2F 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gucy2f 35
  • 88.63 (n)
  • 89.8 (a)
oppossum
(Monodelphis domestica)
Mammalia GUCY2F 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GUCY2F 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves GUCY2F 35
  • 63.03 (n)
  • 61.47 (a)
GUCY2F 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GUCY2F 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy2f 35
  • 70.18 (n)
  • 71.74 (a)
zebrafish
(Danio rerio)
Actinopterygii gc2 35
  • 63.37 (n)
  • 64.18 (a)
gucy2f 35
gc2 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5719 37
  • 52 (a)
CG9783 37
  • 56 (a)
Gyc32E 37
  • 33 (a)
Gyc76C 37
  • 33 (a)
CG34357 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-11 37
  • 30 (a)
gcy-11 37
  • 39 (a)
gcy-12 37
  • 31 (a)
gcy-13 37
  • 41 (a)
gcy-14 37
  • 42 (a)
gcy-15 37
  • 41 (a)
gcy-19 37
  • 42 (a)
gcy-2 37
  • 42 (a)
gcy-20 37
  • 39 (a)
gcy-21 37
  • 43 (a)
gcy-22 37
  • 43 (a)
gcy-23 37
  • 38 (a)
gcy-27 37
  • 31 (a)
gcy-3 37
  • 37 (a)
gcy-31 37
  • 42 (a)
gcy-4 37
  • 39 (a)
gcy-5 37
  • 30 (a)
gcy-6 37
  • 43 (a)
gcy-8 37
  • 38 (a)
odr-1 37
  • 33 (a)
gcy-15 36
  • 27 (a)
ManyToMany
Species with no ortholog for GUCY2F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY2F Gene

ENSEMBL:
Gene Tree for GUCY2F (if available)
TreeFam:
Gene Tree for GUCY2F (if available)

Paralogs for GUCY2F Gene

(3) SIMAP similar genes for GUCY2F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GUCY2F: view

Variants for GUCY2F Gene

Sequence variations from dbSNP and Humsavar for GUCY2F Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs480070 -- 109,406,146(-) TGAAC(A/G)CCATG intron-variant
rs482268 -- 109,463,685(-) ctgag(G/T)cgggt intron-variant
rs484369 -- 109,439,072(-) ccacg(C/T)ggtgc intron-variant
rs494589 -- 109,481,907(-) GCATG(C/T)GCAGG utr-variant-5-prime
rs502209 - 109,465,287(-) CTACC(A/C/G/T)GGTCC missense, reference, nc-transcript-variant

Variation tolerance for GUCY2F Gene

Residual Variation Intolerance Score: 98.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.19; 87.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUCY2F Gene

HapMap Linkage Disequilibrium report
GUCY2F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GUCY2F Gene

Disorders for GUCY2F Gene

MalaCards: The human disease database

(2) MalaCards diseases for GUCY2F Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leber congenital amaurosis
  • leber's amaurosis
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association

Relevant External Links for GUCY2F

Genetic Association Database (GAD)
GUCY2F
Human Genome Epidemiology (HuGE) Navigator
GUCY2F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GUCY2F
genes like me logo Genes that share disorders with GUCY2F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCY2F Gene

Publications for GUCY2F Gene

  1. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. (PMID: 8838319) Yang R.B. … Garbers D.L. (Genomics 1996) 2 23 67
  2. Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2. (PMID: 7777544) Lowe D.G. … Hurley J.B. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 23 67
  3. Novel functions of photoreceptor guanylate cyclases revealed by targeted deletion. (PMID: 20012162) Karan S. … Baehr W. (Mol. Cell. Biochem. 2010) 23 67
  4. Guanylate cyclases and associated activator proteins in retinal disease. (PMID: 19941038) Hunt D.M. … Michaelides M. (Mol. Cell. Biochem. 2010) 23 67
  5. Domain analysis of human transmembrane guanylyl cyclase receptors: implications for regulation. (PMID: 15769619) Potter L.R. (Front. Biosci. 2005) 23 67

Products for GUCY2F Gene

Sources for GUCY2F Gene

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