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Aliases for GUCY2F Gene

Aliases for GUCY2F Gene

  • Guanylate Cyclase 2F, Retinal 2 3 4
  • GUC2F 3 4 6
  • Rod Outer Segment Membrane Guanylate Cyclase 2 3 4
  • Guanylate Cyclase F 3 4
  • EC 4 63
  • RETGC-2 3 4
  • ROS-GC2 3 4
  • GC-F 3 4
  • Guanylate Cyclase 2D-Like, Membrane (Retina-Specific) 3
  • Membrane (Retina-Specific) 2
  • Retinal Guanylyl Cyclase 2 3
  • Guanylate Cyclase 2D-Like 2
  • EC 4.6.1 63
  • GUC2DL 3
  • RETGC2 4
  • CYGF 3

External Ids for GUCY2F Gene

Previous GeneCards Identifiers for GUCY2F Gene

  • GC0XM103919
  • GC0XM105762
  • GC0XM106641
  • GC0XM107380
  • GC0XM108422
  • GC0XM108616
  • GC0XM098238

Summaries for GUCY2F Gene

Entrez Gene Summary for GUCY2F Gene

  • The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]

GeneCards Summary for GUCY2F Gene

GUCY2F (Guanylate Cyclase 2F, Retinal) is a Protein Coding gene. Diseases associated with GUCY2F include retinitis pigmentosa. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include protein homodimerization activity and GTP binding. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for GUCY2F Gene

  • Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY2F Gene

Genomics for GUCY2F Gene

Regulatory Elements for GUCY2F Gene

Genomic Location for GUCY2F Gene

109,372,906 bp from pter
109,482,072 bp from pter
109,167 bases
Minus strand

Genomic View for GUCY2F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GUCY2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY2F Gene

Proteins for GUCY2F Gene

  • Protein details for GUCY2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinal guanylyl cyclase 2
    Protein Accession:
    Secondary Accessions:
    • Q9UJF1

    Protein attributes for GUCY2F Gene

    1108 amino acids
    Molecular mass:
    124850 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GUCY2F Gene

Proteomics data for GUCY2F Gene at MOPED

Post-translational modifications for GUCY2F Gene

  • There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GUCY2F Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for GUCY2F Gene

Suggested Antigen Peptide Sequences for GUCY2F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P51841
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 guanylate cyclase domain.
  • Contains 1 protein kinase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY2F: view

No data available for Gene Families for GUCY2F Gene

Function for GUCY2F Gene

Molecular function for GUCY2F Gene

GENATLAS Biochemistry:
guanylate cyclase 2F,membrane form expressed in the retina,homolog to murine Gucyf
UniProtKB/Swiss-Prot CatalyticActivity:
GTP = 3,5-cyclic GMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by GCAP-1; inhibited by calcium
UniProtKB/Swiss-Prot Function:
Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction

Enzyme Numbers (IUBMB) for GUCY2F Gene

Gene Ontology (GO) - Molecular Function for GUCY2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004383 guanylate cyclase activity IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0004872 receptor activity TAS 7777544
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GUCY2F: view

Phenotypes for GUCY2F Gene

MGI mutant phenotypes for GUCY2F:
inferred from 1 alleles
GenomeRNAi human phenotypes for GUCY2F:
genes like me logo Genes that share phenotypes with GUCY2F: view

Animal Models for GUCY2F Gene

MGI Knock Outs for GUCY2F:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCY2F

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for GUCY2F Gene

Localization for GUCY2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY2F Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for GUCY2F Gene COMPARTMENTS Subcellular localization image for GUCY2F gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GUCY2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005640 nuclear outer membrane TAS 7777544
GO:0005887 integral component of plasma membrane TAS 7777544
GO:0016020 membrane --
GO:0097381 photoreceptor disc membrane TAS --
genes like me logo Genes that share ontologies with GUCY2F: view

Pathways for GUCY2F Gene

genes like me logo Genes that share pathways with GUCY2F: view

Gene Ontology (GO) - Biological Process for GUCY2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007168 receptor guanylyl cyclase signaling pathway TAS 7777544
GO:0007601 visual perception IEA --
GO:0007603 phototransduction, visible light TAS --
genes like me logo Genes that share ontologies with GUCY2F: view

Compounds for GUCY2F Gene

(5) HMDB Compounds for GUCY2F Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
Cyclic GMP
  • 3',5'-cyclic GMP
Guanosine triphosphate
  • 5'-GTP
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion

(3) Novoseek inferred chemical compound relationships for GUCY2F Gene

Compound -log(P) Hits PubMed IDs
guanylate 71.4 3
cgmp 55.9 1
calcium 25 2
genes like me logo Genes that share compounds with GUCY2F: view

Transcripts for GUCY2F Gene

mRNA/cDNA for GUCY2F Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GUCY2F Gene

Guanylate cyclase 2F, retinal:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCY2F

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY2F Gene

No ASD Table

Relevant External Links for GUCY2F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GUCY2F Gene

mRNA expression in normal human tissues for GUCY2F Gene

mRNA differential expression in normal tissues according to GTEx for GUCY2F Gene

This gene is overexpressed in Testis (13.6) and Cervix - Endocervix (5.9).

Protein differential expression in normal tissues for GUCY2F Gene

This gene is overexpressed in Cervix (66.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GUCY2F Gene

SOURCE GeneReport for Unigene cluster for GUCY2F Gene Hs.123074

mRNA Expression by UniProt/SwissProt for GUCY2F Gene

Tissue specificity: Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells
genes like me logo Genes that share expressions with GUCY2F: view

Expression partners for GUCY2F Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GUCY2F Gene

Orthologs for GUCY2F Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY2F Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GUCY2F 35
  • 91.26 (n)
  • 90.44 (a)
  • 90 (a)
(Canis familiaris)
Mammalia GUCY2F 35
  • 91.16 (n)
  • 91.34 (a)
  • 91 (a)
(Mus musculus)
Mammalia Gucy2f 35
  • 89.05 (n)
  • 89.89 (a)
Gucy2f 16
Gucy2f 36
  • 90 (a)
(Pan troglodytes)
Mammalia GUCY2F 35
  • 97.71 (n)
  • 97.12 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Gucy2f 35
  • 88.63 (n)
  • 89.8 (a)
(Monodelphis domestica)
Mammalia GUCY2F 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia GUCY2F 36
  • 50 (a)
(Gallus gallus)
Aves GUCY2F 35
  • 63.03 (n)
  • 61.47 (a)
  • 60 (a)
(Anolis carolinensis)
Reptilia GUCY2F 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy2f 35
  • 70.18 (n)
  • 71.74 (a)
(Danio rerio)
Actinopterygii gc2 35
  • 63.37 (n)
  • 64.18 (a)
gucy2f 35
gc2 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5719 37
  • 52 (a)
CG9783 37
  • 56 (a)
Gyc32E 37
  • 33 (a)
Gyc76C 37
  • 33 (a)
CG34357 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea daf-11 37
  • 30 (a)
gcy-11 37
  • 39 (a)
gcy-12 37
  • 31 (a)
gcy-13 37
  • 41 (a)
gcy-14 37
  • 42 (a)
gcy-15 37
  • 41 (a)
gcy-19 37
  • 42 (a)
gcy-2 37
  • 42 (a)
gcy-20 37
  • 39 (a)
gcy-21 37
  • 43 (a)
gcy-22 37
  • 43 (a)
gcy-23 37
  • 38 (a)
gcy-27 37
  • 31 (a)
gcy-3 37
  • 37 (a)
gcy-31 37
  • 42 (a)
gcy-4 37
  • 39 (a)
gcy-5 37
  • 30 (a)
gcy-6 37
  • 43 (a)
gcy-8 37
  • 38 (a)
odr-1 37
  • 33 (a)
gcy-15 36
  • 27 (a)
Species with no ortholog for GUCY2F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY2F Gene

Gene Tree for GUCY2F (if available)
Gene Tree for GUCY2F (if available)

Paralogs for GUCY2F Gene

Selected SIMAP similar genes for GUCY2F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GUCY2F: view

Variants for GUCY2F Gene

Sequence variations from dbSNP and Humsavar for GUCY2F Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs480070 -- 109,406,146(-) TGAAC(A/G)CCATG intron-variant
rs482268 -- 109,463,685(-) ctgag(G/T)cgggt intron-variant
rs484369 -- 109,439,072(-) ccacg(C/T)ggtgc intron-variant
rs494589 -- 109,481,907(-) GCATG(C/T)GCAGG utr-variant-5-prime
rs502209 - 109,465,287(-) CTACC(A/C/G/T)GGTCC missense, reference, nc-transcript-variant

Relevant External Links for GUCY2F Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GUCY2F Gene

Disorders for GUCY2F Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for GUCY2F Gene in MalaCards »

(1) Diseases for GUCY2F Gene including...

(1) University of Copenhagen DISEASES for GUCY2F Gene

Relevant External Links for GUCY2F

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GUCY2F: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for GUCY2F Gene

Publications for GUCY2F Gene

  1. Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2. (PMID: 7777544) Lowe D.G. … Hurley J.B. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23
  2. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. (PMID: 8838319) Yang R.B. … Garbers D.L. (Genomics 1996) 2 3 23
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Genetic mutations associated with cigarette smoking in pancreatic cancer. (PMID: 19351817) Blackford A. … Hruban R.H. (Cancer Res. 2009) 3 48
  5. The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2. (PMID: 9698373) Laura R.P. … Hurley J.B. (Biochemistry 1998) 3 23

Products for GUCY2F Gene

Sources for GUCY2F Gene

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