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Aliases for GUCY2EP Gene

Aliases for GUCY2EP Gene

  • Guanylate Cyclase 2E, Pseudogene 2 3 5
  • Olfactory Guanylate Cyclase 3
  • Guanylate Cyclase 2E 2
  • GUCY2E 3
  • GC-E 3
  • GCD 3

External Ids for GUCY2EP Gene

Previous HGNC Symbols for GUCY2EP Gene

  • GUCY2E

Previous GeneCards Identifiers for GUCY2EP Gene

  • GC11M076392

Summaries for GUCY2EP Gene

Entrez Gene Summary for GUCY2EP Gene

  • This olfactory specific guanylyl cyclase is part of the mammalian olfactory system and and encodes a protein involved in chemosensation in rodents. The gene has become inactivated to become a pseudogene is humans and most primates. [provided by RefSeq, Oct 2008]

GeneCards Summary for GUCY2EP Gene

GUCY2EP (Guanylate Cyclase 2E, Pseudogene) is a Pseudogene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Sertoli-Sertoli Cell Junction Dynamics.

Additional gene information for GUCY2EP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY2EP Gene

Genomics for GUCY2EP Gene

Regulatory Elements for GUCY2EP Gene

Enhancers for GUCY2EP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H076721 1 Ensembl ENCODE 0.7 -0.2 -249 0.7 HDAC1 CTCF RB1 MAX ZIC2 RAD21 RFX5 GATA3 SMC3 ZNF143 GUCY2EP LOC105369397
GH11H076744 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -23.6 -23638 2.4 HDGF ATF1 TCF12 ZNF766 GATA2 ELK1 ATF7 NCOA1 ZNF592 MEF2D ENSG00000254632 ACER3 LOC105369397 GUCY2EP
GH11H076736 0.8 ENCODE 0.4 -14.3 -14263 0.2 HDAC1 TBP ATF1 TAL1 TCF12 CTBP1 POLR2A GATA2 NCOR1 TRIM24 ENSG00000254632 GUCY2EP LOC105369397
GH11H076734 0.7 ENCODE 0.4 -12.3 -12333 0.2 CTCF ZNF654 RB1 REST ZEB2 RAD21 CC2D1A NFIC TARDBP ZNF143 ENSG00000254632 GUCY2EP LOC105369397
GH11H076747 0.9 ENCODE dbSUPER 0.3 -26.6 -26592 1.8 HDAC1 L3MBTL2 GATA2 EGR1 MNT MYC MGA ZNF592 ENSG00000254632 LOC105369397 GUCY2EP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GUCY2EP on UCSC Golden Path with GeneCards custom track

Genomic Locations for GUCY2EP Gene

Genomic Locations for GUCY2EP Gene
41,624 bases
Minus strand

Genomic View for GUCY2EP Gene

Genes around GUCY2EP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCY2EP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCY2EP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY2EP Gene

Proteins for GUCY2EP Gene

Post-translational modifications for GUCY2EP Gene

No Post-translational modifications

No data available for DME Specific Peptides for GUCY2EP Gene

Domains & Families for GUCY2EP Gene

Gene Families for GUCY2EP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GUCY2EP: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GUCY2EP Gene

Function for GUCY2EP Gene

Phenotypes From GWAS Catalog for GUCY2EP Gene

Phenotypes for GUCY2EP Gene

GenomeRNAi human phenotypes for GUCY2EP:
genes like me logo Genes that share phenotypes with GUCY2EP: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GUCY2EP Gene

Localization for GUCY2EP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GUCY2EP Gene

Pathways & Interactions for GUCY2EP Gene

genes like me logo Genes that share pathways with GUCY2EP: view

Pathways by source for GUCY2EP Gene

Interacting Proteins for GUCY2EP Gene

Gene Ontology (GO) - Biological Process for GUCY2EP Gene


No data available for SIGNOR curated interactions for GUCY2EP Gene

Drugs & Compounds for GUCY2EP Gene

No Compound Related Data Available

Transcripts for GUCY2EP Gene

mRNA/cDNA for GUCY2EP Gene

(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GUCY2EP Gene

Guanylate cyclase 2E, pseudogene:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY2EP Gene

No ASD Table

Relevant External Links for GUCY2EP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GUCY2EP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GUCY2EP Gene

mRNA differential expression in normal tissues according to GTEx for GUCY2EP Gene

This gene is overexpressed in Kidney - Cortex (x13.2) and Liver (x10.3).

NURSA nuclear receptor signaling pathways regulating expression of GUCY2EP Gene:


SOURCE GeneReport for Unigene cluster for GUCY2EP Gene:

genes like me logo Genes that share expression patterns with GUCY2EP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCY2EP Gene

Orthologs for GUCY2EP Gene

Evolution for GUCY2EP Gene

Gene Tree for GUCY2EP (if available)
Gene Tree for GUCY2EP (if available)

No data available for Orthologs for GUCY2EP Gene

Paralogs for GUCY2EP Gene

No data available for Paralogs for GUCY2EP Gene

Variants for GUCY2EP Gene

Sequence variations from dbSNP and Humsavar for GUCY2EP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000104831 -- 76,681,074(+) GATGG(A/G)GAGAC intron-variant
rs1000174680 -- 76,689,050(+) AGAGG(A/C)TCTGG nc-transcript-variant
rs1000221643 -- 76,714,977(+) TCACA(C/T)TTCTT intron-variant
rs1000317183 -- 76,696,452(+) TCCAT(A/G/T)TTGGC intron-variant
rs1000328983 -- 76,719,295(+) GAGCA(C/T)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GUCY2EP Gene

Variant ID Type Subtype PubMed ID
nsv509433 CNV insertion 20534489
nsv39437 CNV deletion 16902084
nsv1139514 CNV deletion 24896259
nsv1127211 CNV deletion 24896259
nsv1047069 CNV gain 25217958
esv3548017 CNV deletion 23714750
esv2744798 CNV deletion 23290073
esv2744797 CNV deletion 23290073
esv2744795 CNV deletion 23290073
esv2744794 CNV deletion 23290073
esv2744793 CNV deletion 23290073
esv2675807 CNV deletion 23128226
esv1729465 CNV deletion 17803354
dgv1228n100 CNV loss 25217958

Relevant External Links for GUCY2EP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GUCY2EP Gene

Disorders for GUCY2EP Gene

Relevant External Links for GUCY2EP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GUCY2EP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GUCY2EP Gene

Publications for GUCY2EP Gene

  1. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. (PMID: 8838319) Yang RB … Garbers DL (Genomics 1996) 2 3 22 60
  2. Novel functions of photoreceptor guanylate cyclases revealed by targeted deletion. (PMID: 20012162) Karan S … Baehr W (Molecular and cellular biochemistry 2010) 3 60
  3. Degeneration of the olfactory guanylyl cyclase D gene during primate evolution. (PMID: 17849013) Young JM … Liman ER (PloS one 2007) 3 60
  4. Comparative genomics search for losses of long-established genes on the human lineage. (PMID: 18085818) Zhu J … Haussler D (PLoS computational biology 2007) 3 60
  5. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers. (PMID: 9153227) Yang RB … Garbers DL (The Journal of biological chemistry 1997) 3 60

Products for GUCY2EP Gene

Sources for GUCY2EP Gene

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