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Aliases for GUCY2EP Gene

Aliases for GUCY2EP Gene

  • Guanylate Cyclase 2E, Pseudogene 2 3 5
  • Olfactory Guanylate Cyclase 3
  • Guanylate Cyclase 2E 2
  • GUCY2E 3
  • GC-E 3
  • GCD 3

External Ids for GUCY2EP Gene

Previous HGNC Symbols for GUCY2EP Gene

  • GUCY2E

Previous GeneCards Identifiers for GUCY2EP Gene

  • GC11M076392

Summaries for GUCY2EP Gene

Entrez Gene Summary for GUCY2EP Gene

  • This olfactory specific guanylyl cyclase is part of the mammalian olfactory system and and encodes a protein involved in chemosensation in rodents. The gene has become inactivated to become a pseudogene is humans and most primates. [provided by RefSeq, Oct 2008]

GeneCards Summary for GUCY2EP Gene

GUCY2EP (Guanylate Cyclase 2E, Pseudogene) is a Pseudogene. Among its related pathways are Sweet Taste Signaling and Sertoli-Sertoli Cell Junction Dynamics.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY2EP Gene

Genomics for GUCY2EP Gene

Regulatory Elements for GUCY2EP Gene

Enhancers for GUCY2EP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G076721 1 Ensembl ENCODE 0.7 -0.2 -249 0.7 HDAC1 CTCF ESRRA RB1 MAX ZIC2 RAD21 RFX5 GATA3 ZNF143 GUCY2EP LOC105369397
GH11G076744 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -23.6 -23638 2.4 HDGF ATF1 TCF12 ZNF766 ELK1 GATA2 FOS NCOA1 REST ZNF592 ENSG00000254632 ACER3 LOC105369397 GUCY2EP
GH11G076734 1 ENCODE 0.4 -12.3 -12333 0.2 PKNOX1 ATF1 CREB3L1 DMAP1 YY1 SLC30A9 GLIS2 ZNF766 ZNF143 ZMIZ1 ENSG00000254632 GUCY2EP LOC105369397
GH11G076736 0.8 ENCODE 0.4 -14.3 -14263 0.2 HDAC1 ATF1 CREB3L1 TCF12 GATA2 CREM ZNF592 TFDP1 NFIC MTA1 ENSG00000254632 GUCY2EP LOC105369397
GH11G076747 1 ENCODE dbSUPER 0.3 -26.6 -26592 1.8 HDAC1 CTCF PKNOX1 RNF2 L3MBTL2 MNT RAD21 ZBTB7A ATF2 ZNF592 ENSG00000254632 LOC105369397 GUCY2EP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GUCY2EP on UCSC Golden Path with GeneCards custom track

Genomic Location for GUCY2EP Gene

Chromosome:
11
Start:
76,680,166 bp from pter
End:
76,721,789 bp from pter
Size:
41,624 bases
Orientation:
Minus strand

Genomic View for GUCY2EP Gene

Genes around GUCY2EP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCY2EP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCY2EP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY2EP Gene

Proteins for GUCY2EP Gene

Post-translational modifications for GUCY2EP Gene

No Post-translational modifications

No data available for DME Specific Peptides for GUCY2EP Gene

Domains & Families for GUCY2EP Gene

Gene Families for GUCY2EP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GUCY2EP: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GUCY2EP Gene

Function for GUCY2EP Gene

Phenotypes for GUCY2EP Gene

GenomeRNAi human phenotypes for GUCY2EP:
genes like me logo Genes that share phenotypes with GUCY2EP: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GUCY2EP Gene

Localization for GUCY2EP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GUCY2EP Gene

Pathways & Interactions for GUCY2EP Gene

genes like me logo Genes that share pathways with GUCY2EP: view

Pathways by source for GUCY2EP Gene

Interacting Proteins for GUCY2EP Gene

Gene Ontology (GO) - Biological Process for GUCY2EP Gene

None

No data available for SIGNOR curated interactions for GUCY2EP Gene

Drugs & Compounds for GUCY2EP Gene

No Compound Related Data Available

Transcripts for GUCY2EP Gene

mRNA/cDNA for GUCY2EP Gene

(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GUCY2EP Gene

Guanylate cyclase 2E, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY2EP Gene

No ASD Table

Relevant External Links for GUCY2EP Gene

GeneLoc Exon Structure for
GUCY2EP
ECgene alternative splicing isoforms for
GUCY2EP

Expression for GUCY2EP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GUCY2EP Gene

mRNA differential expression in normal tissues according to GTEx for GUCY2EP Gene

This gene is overexpressed in Kidney - Cortex (x13.2) and Liver (x10.3).

NURSA nuclear receptor signaling pathways regulating expression of GUCY2EP Gene:

GUCY2EP

SOURCE GeneReport for Unigene cluster for GUCY2EP Gene:

Hs.440026
genes like me logo Genes that share expression patterns with GUCY2EP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCY2EP Gene

Orthologs for GUCY2EP Gene

Evolution for GUCY2EP Gene

ENSEMBL:
Gene Tree for GUCY2EP (if available)
TreeFam:
Gene Tree for GUCY2EP (if available)

No data available for Orthologs for GUCY2EP Gene

Paralogs for GUCY2EP Gene

No data available for Paralogs for GUCY2EP Gene

Variants for GUCY2EP Gene

Sequence variations from dbSNP and Humsavar for GUCY2EP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000104831 -- 76,681,074(+) GATGG(A/G)GAGAC intron-variant
rs1000174680 -- 76,689,050(+) AGAGG(A/C)TCTGG nc-transcript-variant
rs1000221643 -- 76,714,977(+) TCACA(C/T)TTCTT intron-variant
rs1000317183 -- 76,696,452(+) TCCAT(A/G/T)TTGGC intron-variant
rs1000328983 -- 76,719,295(+) GAGCA(C/T)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GUCY2EP Gene

Variant ID Type Subtype PubMed ID
dgv1228n100 CNV loss 25217958
esv1729465 CNV deletion 17803354
esv2675807 CNV deletion 23128226
esv2744793 CNV deletion 23290073
esv2744794 CNV deletion 23290073
esv2744795 CNV deletion 23290073
esv2744797 CNV deletion 23290073
esv2744798 CNV deletion 23290073
esv3548017 CNV deletion 23714750
nsv1047069 CNV gain 25217958
nsv1127211 CNV deletion 24896259
nsv1139514 CNV deletion 24896259
nsv39437 CNV deletion 16902084
nsv509433 CNV insertion 20534489

Relevant External Links for GUCY2EP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GUCY2EP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GUCY2EP Gene

Disorders for GUCY2EP Gene

Relevant External Links for GUCY2EP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GUCY2EP

No disorders were found for GUCY2EP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GUCY2EP Gene

Publications for GUCY2EP Gene

  1. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. (PMID: 8838319) Yang R.B. … Garbers D.L. (Genomics 1996) 2 3 22 64
  2. Novel functions of photoreceptor guanylate cyclases revealed by targeted deletion. (PMID: 20012162) Karan S. … Baehr W. (Mol. Cell. Biochem. 2010) 3 64
  3. Degeneration of the olfactory guanylyl cyclase D gene during primate evolution. (PMID: 17849013) Young J.M. … Liman E.R. (PLoS ONE 2007) 3 64
  4. Comparative genomics search for losses of long-established genes on the human lineage. (PMID: 18085818) Zhu J. … Haussler D. (PLoS Comput. Biol. 2007) 3 64
  5. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers. (PMID: 9153227) Yang R.B. … Garbers D.L. (J. Biol. Chem. 1997) 3 64

Products for GUCY2EP Gene

Sources for GUCY2EP Gene

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