Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GUCY2C Gene

Aliases for GUCY2C Gene

  • Guanylate Cyclase 2C 2 3
  • STA Receptor 2 3 4
  • GUC2C 3 4 6
  • Heat Stable Enterotoxin Receptor 2 3
  • Intestinal Guanylate Cyclase 3 4
  • Guanylyl Cyclase C 3 4
  • EC 4 63
  • DIAR6 3 6
  • MECIL 3 6
  • HSTAR 3 4
  • StAR 3 4
  • GC-C 3 4
  • Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor) 2
  • Heat-Stable Enterotoxin Receptor 3
  • EC 4.6.1 63
  • MUCIL 3

External Ids for GUCY2C Gene

Previous HGNC Symbols for GUCY2C Gene

  • GUC2C

Previous GeneCards Identifiers for GUCY2C Gene

  • GC12M014505
  • GC12M014910
  • GC12M014665
  • GC12M014656
  • GC12M014765
  • GC12M014534

Summaries for GUCY2C Gene

GeneCards Summary for GUCY2C Gene

GUCY2C (Guanylate Cyclase 2C) is a Protein Coding gene. Diseases associated with GUCY2C include meconium ileus and diarrhea 6. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include GTP binding and guanylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for GUCY2C Gene

  • Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin

Gene Wiki entry for GUCY2C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY2C Gene

Genomics for GUCY2C Gene

Regulatory Elements for GUCY2C Gene

Genomic Location for GUCY2C Gene

14,612,632 bp from pter
14,696,585 bp from pter
83,954 bases
Minus strand

Genomic View for GUCY2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GUCY2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY2C Gene

Proteins for GUCY2C Gene

  • Protein details for GUCY2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat-stable enterotoxin receptor
    Protein Accession:
    Secondary Accessions:
    • B2RMY6

    Protein attributes for GUCY2C Gene

    1073 amino acids
    Molecular mass:
    123403 Da
    Quaternary structure:
    • Homotrimer. Interacts via its C-terminal region with PDZK2. Interacts with the lectin chaperone VIP36.

neXtProt entry for GUCY2C Gene

Proteomics data for GUCY2C Gene at MOPED

Post-translational modifications for GUCY2C Gene

  • Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation.
  • Glycosylation at Asn32, Asn75, Asn79, Asn195, Asn284, Asn307, Asn345, and Asn402
  • Modification sites at PhosphoSitePlus

Other Protein References for GUCY2C Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for GUCY2C Gene

Suggested Antigen Peptide Sequences for GUCY2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P25092
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 guanylate cyclase domain.
  • Contains 1 protein kinase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY2C: view

Function for GUCY2C Gene

Molecular function for GUCY2C Gene

GENATLAS Biochemistry: guanylate cyclase C,transmembrane receptor primarily expressed in the intestine
UniProtKB/Swiss-Prot CatalyticActivity: GTP = 3,5-cyclic GMP + diphosphate
UniProtKB/Swiss-Prot Function: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin

Enzyme Numbers (IUBMB) for GUCY2C Gene

Gene Ontology (GO) - Molecular Function for GUCY2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004383 guanylate cyclase activity IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 11950846
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with GUCY2C: view
genes like me logo Genes that share phenotypes with GUCY2C: view

Animal Models for GUCY2C Gene

MGI Knock Outs for GUCY2C:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for GUCY2C Gene

Localization for GUCY2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY2C Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The 145 kDa plasma membrane form of GC-C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.

Subcellular locations from

Jensen Localization Image for GUCY2C Gene COMPARTMENTS Subcellular localization image for GUCY2C gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
extracellular 3
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GUCY2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GUCY2C: view

Pathways for GUCY2C Gene

genes like me logo Genes that share pathways with GUCY2C: view

Pathways by source for GUCY2C Gene

Gene Ontology (GO) - Biological Process for GUCY2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007168 receptor guanylyl cyclase signaling pathway TAS 1680854
GO:0009190 cyclic nucleotide biosynthetic process --
GO:0009636 response to toxic substance IEA --
genes like me logo Genes that share ontologies with GUCY2C: view

Compounds for GUCY2C Gene

(5) HMDB Compounds for GUCY2C Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic GMP
  • 3',5'-cyclic GMP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion

(1) Drugbank Compounds for GUCY2C Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
851199-59-2 target agonist

(3) IUPHAR Ligand for GUCY2C Gene

Ligand Type Action Affinity Pubmed IDs
linaclotide Agonist Agonist
E. coli heat-stable enterotoxin (STa) Agonist Agonist
[125I]Sta None None

(10) Novoseek inferred chemical compound relationships for GUCY2C Gene

Compound -log(P) Hits PubMed IDs
enterotoxin 91.3 44
cgmp 71.4 11
2 chloroadenosine 44.9 2
guanylate 38.1 2
paraffin 22.6 2
genes like me logo Genes that share compounds with GUCY2C: view

Transcripts for GUCY2C Gene

mRNA/cDNA for GUCY2C Gene

Unigene Clusters for GUCY2C Gene

Guanylate cyclase 2C (heat stable enterotoxin receptor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY2C Gene

No ASD Table

Relevant External Links for GUCY2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GUCY2C Gene

mRNA expression in normal human tissues for GUCY2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GUCY2C Gene

This gene is overexpressed in Colon - Transverse (24.1) and Small Intestine - Terminal Ileum (18.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GUCY2C Gene

SOURCE GeneReport for Unigene cluster for GUCY2C Gene Hs.524278

genes like me logo Genes that share expressions with GUCY2C: view

No data available for mRNA Expression by UniProt/SwissProt for GUCY2C Gene

Orthologs for GUCY2C Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY2C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GUCY2C 35
  • 99.53 (n)
  • 99.35 (a)
  • 99 (a)
(Bos Taurus)
Mammalia GUCY2C 35
  • 86.38 (n)
  • 85.45 (a)
  • 86 (a)
(Canis familiaris)
Mammalia GUCY2C 35
  • 88.12 (n)
  • 88.44 (a)
  • 88 (a)
(Mus musculus)
Mammalia Gucy2c 35
  • 81.19 (n)
  • 82.42 (a)
Gucy2c 16
Gucy2c 36
  • 82 (a)
(Monodelphis domestica)
Mammalia GUCY2C 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia GUCY2C 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Gucy2c 35
  • 81.81 (n)
  • 83 (a)
(Gallus gallus)
Aves GUCY2C 35
  • 70.31 (n)
  • 68.47 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia GUCY2C 36
  • 73 (a)
African clawed frog
(Xenopus laevis)
Amphibia gucy2c-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy2c 35
  • 64.63 (n)
  • 63.97 (a)
(Danio rerio)
Actinopterygii gucy2c 36
  • 67 (a)
GUCY2C (2 of 2) 36
  • 53 (a)
LOC572052 35
  • 60.18 (n)
  • 57.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33958 36
  • 26 (a)
CG5719 37
  • 52 (a)
(Caenorhabditis elegans)
Secernentea gcy-21 36
  • 22 (a)
gcy-19 37
  • 37 (a)
gcy-4 37
  • 38 (a)
gcy-3 37
  • 35 (a)
daf-11 37
  • 30 (a)
gcy-27 37
  • 34 (a)
odr-1 37
  • 33 (a)
gcy-2 37
  • 36 (a)
gcy-8 37
  • 32 (a)
Species with no ortholog for GUCY2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY2C Gene

Gene Tree for GUCY2C (if available)
Gene Tree for GUCY2C (if available)

Paralogs for GUCY2C Gene

Selected SIMAP similar genes for GUCY2C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GUCY2C: view

Variants for GUCY2C Gene

Sequence variations from dbSNP and Humsavar for GUCY2C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs247327 -- 14,688,590(+) TTatc(C/T)atcca intron-variant
rs247328 -- 14,691,562(+) GAGGG(C/T)AGCAC intron-variant
rs247329 -- 14,692,850(+) gtccc(A/G)aataa intron-variant
rs247330 -- 14,694,617(-) GTGAA(A/G)TCCCC intron-variant
rs247343 -- 14,698,518(-) TACCC(C/T)TAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GUCY2C Gene

Variant ID Type Subtype PubMed ID
nsv898817 CNV Gain 21882294
nsv528779 CNV Loss 19592680

Relevant External Links for GUCY2C Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCY2C Gene

Disorders for GUCY2C Gene

(2) OMIM Diseases for GUCY2C Gene (601330)


  • Diarrhea 6 (DIAR6) [MIM:614616]: A relatively mild, early-onset chronic diarrhea that may be associated with increased susceptibility to inflammatory bowel disease, small bowel obstruction, and esophagitis. {ECO:0000269 PubMed:22436048}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Meconium ileus (MECIL) [MIM:614665]: A condition characterized by a intestinal obstruction due to inspissated meconium in the distal ileum and cecum, which develops in utero and presents shortly after birth as a failure to pass meconium. Meconium ileus is a known clinical manifestation of cystic fibrosis. {ECO:0000269 PubMed:22521417}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(15) Novoseek inferred disease relationships for GUCY2C Gene

Disease -log(P) Hits PubMed IDs
colorectal tumors 74.4 4
colorectal cancer 66.8 27
colon carcinoma 58.7 8
colon cancer 52.5 8
colorectal carcinoma 47.1 6
genes like me logo Genes that share disorders with GUCY2C: view

Publications for GUCY2C Gene

  1. Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line. (PMID: 1718270) Singh S. … Gerzer R. (Biochem. Biophys. Res. Commun. 1991) 3 4 23
  2. Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin receptor gene. (PMID: 8605253) Mann E.A. … Giannella R.A. (Biochim. Biophys. Acta 1996) 3 4 23
  3. Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin. (PMID: 1680854) de Sauvage F.J. … Goeddel D.V. (J. Biol. Chem. 1991) 3 4 23
  4. Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer. (PMID: 11123935) Vijayachandra K. … Visweswariah S.S. (Biochemistry 2000) 4 23
  5. Functional inactivation of the human guanylyl cyclase C receptor: modeling and mutation of the protein kinase-like domain. (PMID: 11478887) Bhandari R. … Visweswariah S.S. (Biochemistry 2001) 3 23

Products for GUCY2C Gene

  • antibodies-online proteins for GUCY2C
  • antibodies-online antibodies for GUCY2C
  • antibodies-online kits for GUCY2C

Sources for GUCY2C Gene

Back to Top