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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GUCY2C Gene

protein-coding   GIFtS: 62
GCID: GC12M014765

guanylate cyclase 2C (heat stable enterotoxin receptor)


(Previous symbol: GUC2C)
 Explore 28 diseases affiliated with
GUCY2C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GUCY2C    

Aliases
for GUCY2C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)1 2     STA Receptor2 3
GUC2C1 2 3 5     EC 4.6.1.23 8
STAR1 2 3     DIAR62
Guanylyl Cyclase C2 3     MECIL2
Intestinal Guanylate Cyclase2 3     MUCIL2
GC-C2 3     Heat-Stable Enterotoxin Receptor2
HSTAR1     EC 4.6.18

External Ids:    HGNC: 46881   Entrez Gene: 29842   Ensembl: ENSG000000700197   OMIM: 6013305   UniProtKB: P250923   
ORGUL members:         
NONCODE:n341839    

Export aliases for GUCY2C gene to outside databases

Previous GC identifers: GC12M014505 GC12M014910 GC12M014665 GC12M014656 GC12M014534


Summaries
for GUCY2C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: GUC2C_HUMAN, P25092
Function: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of
cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin

Gene Wiki entry for GUCY2C (Guanylate cyclase 2C)


Genomic Views
for GUCY2C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GUCY2C gene promoter:
         ER-alpha   Sox5   STAT5A   LCR-F1   Arnt   PPAR-alpha   AREB6   RORalpha1   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GUCY2C promoter sequence
   Search SABiosciences Chromatin IP Primers for GUCY2C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GUCY2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12

GUCY2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GUCY2C gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M014765:  view genomic region     (about GC identifiers)

Start:
 14,765,566 bp from pter      End:
 14,849,519 bp from pter
Size:
 83,954 bases      Orientation:
 minus strand

Proteins
for GUCY2C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GUC2C_HUMAN, P25092 (See protein sequence)
Recommended Name: Heat-stable enterotoxin receptor precursor  
Size: 1073 amino acids; 123403 Da
Subunit: Homotrimer. Interacts via its C-terminal region with PDZK2
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B2RMY6

Explore the universe of human proteins at neXtProt for GUCY2C: NX_P25092

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P25092

    • 4/15 DME Specific Peptides for GUCY2C (P25092) (see all 15)
     ASRMEST  LLFGHML  FSDIVGFT  RGETYLKG 

    GUCY2C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004954.2  
    ENSEMBL proteins: 
     ENSP00000261170  

    Human Recombinant Protein Products: 
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    Novus Biologicals GUCY2C Protein
    Novus Biologicals GUCY2C Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GUCY2C

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0016021integral to membrane IEA--


    GUCY2C for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for GUCY2C

    Protein Domains /
    Families
    for GUCY2C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GUCY2C for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P25092

    ProtoNet protein and cluster: P25092

    1 Blocks protein family: IPB001828 Extracellular ligand-binding receptor

    UniProtKB/Swiss-Prot: GUC2C_HUMAN, P25092
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 1 guanylate cyclase domain
    Similarity: Contains 1 protein kinase domain


    Function
    for GUCY2C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GUC2C_HUMAN, P25092
    Function: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of
    cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin
    Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate

         Genatlas biochemistry entry for GUCY2C:
    guanylate cyclase C,transmembrane receptor primarily expressed in the intestine

    Enzyme Numbers (IUBMB): EC 4.6.1.21 2 EC 4.6.12

    miRNA
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    hsa-miR-30c hsa-miR-30a hsa-miR-544 hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmid: GUCY2C 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004383guanylate cyclase activity IEA--
    GO:0004672protein kinase activity IEA--
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI11950846
    GO:0005524ATP binding IEA--


    GUCY2C for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GUCY2C:
     Decreased circadian period len 

    Animal Models:
         Mouse knock-outs for GUCY2C: Gucy2ctm1Gian Gucy2ctm1Gar
         10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gucy2c):
     adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  growth/size 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    GUCY2C for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GUCY2C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sweet Taste Signaling
    		Cellular Effects of Sildenafil0.46
    		Sperm Motility0.36
    2Visual Cycle in Retinal Rods
    		Visual Cycle in Retinal Rods1.00
    3Signaling in Gap Junctions
    		Signaling in Gap Junctions1.00
    4Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    5Purine metabolism
    		Purine metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GUCY2C (see all 7)
        Cellular Effects of Sildenafil
    Sertoli-Sertoli Cell Junction Dynamics
    eNOS Signaling
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods


    1         Kegg Pathway  (Kegg details for GUCY2C):
        Purine metabolism


    GUCY2C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GUCY2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/74 Interacting proteins for GUCY2C (P250922, 3 ENSP000002611704) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDZD3Q86UT52, 3, ENSP000003271074MINT-1773222 MINT-1777648 MINT-1777755 MINT-1777668 I2D: score=1 STRING: ENSP00000327107
    PDZK1Q5T2W12, 3, ENSP000003421434MINT-1777734 I2D: score=1 STRING: ENSP00000342143
    GUCA2AQ027473, ENSP000003494934I2D: score=1 STRING: ENSP00000349493
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    NME1-NME2ENSP000003768864STRING: ENSP00000376886
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006182cGMP biosynthetic process ----
    GO:0007168receptor guanylyl cyclase signaling pathway TAS1680854
    GO:0009636response to toxin IEA--
    GO:0035556intracellular signal transduction IEA--
    GO:0042127regulation of cell proliferation IEA--


    GUCY2C for ontologies           About GeneDecksing



    Drugs & Compounds
    for GUCY2C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GUCY2C for compounds           About GeneDecksing

    EMD Millipore small molecules for GUCY2C:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GUCY2C

    5 HMDB Compounds for GUCY2C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    10 Novoseek chemical compound relationships for GUCY2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    enterotoxin 91.3 47 1718270 (2), 11931628 (2), 1701694 (2), 8797807 (1) (see all 41)
    cgmp 71.4 12 15937149 (2), 9516400 (2), 1680854 (1), 9188791 (1) (see all 9)
    2 chloroadenosine 44.9 3 8995360 (2)
    guanylate 38.1 3 1718270 (1), 8096619 (1)
    paraffin 22.6 2 12763211 (1), 16049286 (1)
    chloride 14.7 1 10224234 (1)
    atp 6.94 1 11478887 (1)
    magnesium 0 1 15937149 (1)
    calcium 0 5 15937149 (5)
    tyrosine 0 3 11120586 (1)

    Search CenterWatch for drugs/clinical trials and news about GUCY2C / GUC2C 

    Transcripts
    for GUCY2C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GUCY2C gene: 
    NM_004963.3  

    Unigene Cluster for GUCY2C:

    Guanylate cyclase 2C (heat stable enterotoxin receptor)
    Hs.524278  [show with all ESTs]
    Unigene Representative Sequence: NM_004963
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261170(uc001rcd.3) ENST00000535803(uc009zhz.2)

    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK310034.1 BC136544.1 BC136545.1 M73489.1 S57551.1 

    3 DOTS entries:

    DT.409598  DT.95266495  DT.97781094 

    24/29 AceView cDNA sequences (see all 29):

    NM_004963 AW848739 BM746765 AI832359 AI357407 AI446632 BX480883 M73489 
    AW376842 AI732333 BX480841 S57551 AW578382 BM765195 AA514592 AW779607 
    BX483321 AA129983 AW362865 BF756855 AA524004 BG982246 AA565990 AW859797 

    GeneLoc Exon Structure


    Expression
    for GUCY2C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GUCY2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATCAGATGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See GUCY2C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GUCY2C

    SOURCE GeneReport for Unigene cluster: Hs.524278
        SABiosciences Custom PCR Arrays for GUCY2C
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for GUCY2C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GUCY2C gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GUCY2C1 guanylate cyclase 2C (heat stable enterotoxin receptor) 69.95(n)
    67.95(a)    		   417968  XM_416207.3  XP_416207.2 
    lizard
    (Anolis carolinensis)    		 Reptilia GUCY2C6
    		 --
    		 73(a)
    		 1 ↔ 1
    		 GL343714.1(336-56449)
    African clawed frog
    (Xenopus laevis)    		 Amphibia gucy2c-A2 guanylate cyclase 2C (heat stable enterotoxin receptor) 77.7(n)    D49837.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5720521 heat-stable enterotoxin receptor-like 60.33(n)
    58.18(a)    		   572052  XM_695711.5  XP_700803.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG57193 guanylate cyclase 52(a)   55B12   --
    worm
    (Caenorhabditis elegans)    		 Secernentea gcy-43 guanylate cyclase 38(a)
    (best of 8)    		   II(10304047-10308764)   --


    ENSEMBL Gene Tree for GUCY2C (if available)
    TreeFam Gene Tree for GUCY2C (if available) 

    Paralogs
    for GUCY2C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GUCY2C gene
    ADCY52  ADCY22  GUCY2D2  NPR12  ADCY82  GUCY2F2  GUCY1A22  ADCY72  
    ADCY92  GUCY1B32  ADCY62  GUCY1A32  ADCY12  ADCY42  NPR22  ADCY32  
    3 SIMAP similar genes for GUCY2C using alignment to 2 protein entries:     GUC2C_HUMAN (see all proteins):
    NPR1    ADCY4    NPR2

    GUCY2C for paralogs           About GeneDecksing



    Genomic Variants
    for GUCY2C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1466 NCBI SNPs in GUCY2C are shown (see all 1466)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1877623691,2
    		--14765194(+) GGTGGA/CGCAGT 1 -- int10--------
    rs1423973801,2
    		--14765211(+) TGAAGA/TGAGTA 1 -- int10--------
    rs1513326261,2
    		--14765255(+) AGCCTG/TGAGAC 1 -- int10--------
    rs1166949011,2
    		F,--14765266(+) ATGGAT/ATACTT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1911236601,2
    		--14765316(+) CTGGGC/TCCCAT 1 -- int10--------
    rs1406008161,2
    		--14765319(+) GGTCCC/TATACT 1 -- int10--------
    rs1453855781,2
    		--14765449(+) AACAAG/TGCTAG 1 -- int10--------
    rs1476694811,2
    		--14765495(+) TTTTTA/CAGTAA 1 -- int10--------
    rs771618181,2
    		C,F,--14765508(+) ACAAGA/CTGATG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs786959141,2
    		C,F,--14765555(+) AGAAAC/TGCATA 1 -- int11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for GUCY2C (14765566 - 14849519 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GUCY2C: --
    Human Gene Mutation Database (HGMD): GUCY2C

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GUCY2C
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    Disorders / Diseases
    for GUCY2C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GUCY2C for disorders           About GeneDecksing

    OMIM gene information: 601330    OMIM disorders: --

    UniProtKB/Swiss-Prot: GUC2C_HUMAN, P25092
  • Defects in GUCY2C are the cause of diarrhea type 6 (DIAR6) [MIM:614616]. A relatively mild, early-onset
    • chronic diarrhea that may be associated with increased susceptibility to inflammatory bowel disease, small-bowel
    obstruction, and esophagitis
  • Defects in GUCY2C are a cause of meconium ileus (MECIL) [MIM:614665]. A condition characterized by a
    • intestinal obstruction due to inspissated meconium in the distal ileum and cecum, which develops in utero and presents
    shortly after birth as a failure to pass meconium. Meconium ileus is a known clinical manifestation of cystic fibrosis

    20/28 diseases for GUCY2C (see all 28):    About MalaCards
    cone-rod dystrophy    leber congenital amaurosis    ovarian mucinous neoplasm    irritable bowel syndrome
    cystic fibrosis    priapism    colorectal cancer    constipation
    colon carcinoma    colon cancer    fibrosis    diarrhea
    aldosteronism    pertussis    ovarian cancer    gastric cancer
    adenocarcinoma    carcinoma    esophagitis    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for GUCY2C:
    Diarrhea

    10/15 Novoseek disease relationships for GUCY2C gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal tumors 74.4 4 8962140 (1), 15937149 (1), 16149873 (1), 17155897 (1)
    colorectal cancer 66.8 28 9514425 (3), 10206298 (2), 10711442 (2), 19800103 (2) (see all 20)
    colon carcinoma 58.7 9 11438734 (2), 7654763 (2), 8962140 (1), 15937149 (1) (see all 6)
    colon cancer 52.5 8 15937149 (2), 9514425 (1), 15264876 (1), 16731751 (1) (see all 7)
    colorectal carcinoma 47.1 6 19800103 (4), 15754294 (1), 18615494 (1)
    metastasis 41.8 5 19537845 (1), 12163327 (1), 12763211 (1), 19800103 (1) (see all 5)
    metaplasia 39.9 2 15754294 (1), 12831335 (1)
    histopathology 38.3 3 9514425 (2), 20498026 (1)
    neoplastic transformation 33.5 1 17687268 (1)
    adenocarcinoma 26 5 15754294 (2), 11884500 (1), 12163327 (1), 12831335 (1)


    Export disorders for GUCY2C gene to outside databases

    Publications
    for GUCY2C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GUCY2C gene, integrated from 9 sources (see all 140):
    (articles sorted by number of sources associating them with GUCY2C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin. (PubMed id 1680854)1, 2, 9 de Sauvage F.J.... Goeddel D.V. (1991)
    2. Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line. (PubMed id 1718270)1, 2, 9 Singh S.... Gerzer R. (1991)
    3. Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin receptor gene. (PubMed id 8605253)1, 2, 9 Mann E.A.... Giannella R.A. (1996)
    4. Meconium ileus caused by mutations in GUCY2C, encoding the CFTR- activating guanylate cyclase 2C. (PubMed id 22521417)1, 2 Romi H....Birk O.S. (2012)
    5. Familial diarrhea syndrome caused by an activating GUCY2C mutation. (PubMed id 22436048)1, 2 Fiskerstrand T.... Knappskog P.M. (2012)
    6. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. (PubMed id 11950846)1, 2 Scott R.O.... Milgram S.L. (2002)
    7. Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12. (PubMed id 8661067)1, 3 Mann E.A....Giannella R.A. (1996)
    8. Comparison of receptors for Escherichia coli heat-stable enterotoxin: novel receptor present in IEC-6 cells. (PubMed id 8381596)1, 2 Mann E.A.... Giannella R.A. (1993)
    9. Guanylyl cyclase C is a specific marker for different iating primary and metastatic ovarian mucinous neoplasms. (PubMed id 19694825)1, 9 Ciocca V....Waldman S.A. (2009)
    10. A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer. (PubMed id 16899600)1, 9 Schulz S....Waldman S.A. (2006)

    External Searches for GUCY2C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing GUCY2C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2984 HGNC: 4688 AceView: GUCY2C Ensembl:ENSG00000070019 euGenes: HUgn2984
    ECgene: GUCY2C Kegg: 2984 H-InvDB: GUCY2C

    Other Databases showing GUCY2C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GUCY2C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GUCY2C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GUCY2C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GUCY2C gene:
    Search GeneIP for patents involving GUCY2C

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