Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GUCY2C Gene

protein-coding   GIFtS: 65
GCID: GC12M014765

Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)


(Previous symbol: GUC2C)
  See GUCY2C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)1 2     STA Receptor2 3
GUC2C1 2 3 5     EC 4.6.1.23 8
Guanylyl Cyclase C2 3     DIAR62 5
Intestinal Guanylate Cyclase2 3     MECIL2 5
GC-C2 3     MUCIL2
STAR2 3     Heat-Stable Enterotoxin Receptor2
hSTAR2 3     EC 4.6.18

External Ids:    HGNC: 46881   Entrez Gene: 29842   Ensembl: ENSG000000700197   OMIM: 6013305   UniProtKB: P250923   

Export aliases for GUCY2C gene to outside databases

Previous GC identifers: GC12M014505 GC12M014910 GC12M014665 GC12M014656 GC12M014534


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for GUCY2C Gene:
GUCY2C (guanylate cyclase 2C (heat stable enterotoxin receptor)) is a protein-coding gene. Diseases associated with GUCY2C include meconium ileus, and chronic diarrhea due to guanylate cyclase 2c overactivity. GO annotations related to this gene include guanylate cyclase activity and GTP binding. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: GUC2C_HUMAN, P25092
Function: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation
of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin

Gene Wiki entry for GUCY2C (Guanylate cyclase 2C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the GUCY2C gene promoter:
         ER-alpha   Sox5   STAT5A   LCR-F1   Arnt   PPAR-alpha   AREB6   RORalpha1   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGUCY2C promoter sequence
   Search Chromatin IP Primers for GUCY2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GUCY2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12

GUCY2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GUCY2C gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M014765:  view genomic region     (about GC identifiers)

Start:
14,765,566 bp from pter      End:
14,849,519 bp from pter
Size:
83,954 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GUC2C_HUMAN, P25092 (See protein sequence)
Recommended Name: Heat-stable enterotoxin receptor precursor  
Size: 1073 amino acids; 123403 Da
Subunit: Homotrimer. Interacts via its C-terminal region with PDZK2. Interacts with the lectin chaperone VIP36
Secondary accessions: B2RMY6

Explore the universe of human proteins at neXtProt for GUCY2C: NX_P25092

Explore proteomics data for GUCY2C at MOPED

Post-translational modifications: 

  • Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and
    Asn-402 modulates ligand-mediated GC-C activation1
  • Glycosylation2 at Asn32, Asn75, Asn79, Asn195, Asn284, Asn307, Asn345, Asn402
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GUCY2C (P25092) (see all 15)
     ASRMEST  LLFGHML  FSDIVGFT  RGETYLKG 


    See GUCY2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004954.2  
    ENSEMBL proteins: 
     ENSP00000261170  

    GUCY2C Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GUCY2C
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GUCY2C
    GenScript Custom Purified and Recombinant Proteins Services for GUCY2C
    Novus Biologicals GUCY2C Protein
    Novus Biologicals GUCY2C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GUCY2C

     
    Search eBioscience for Proteins for GUCY2C 

    GUCY2C Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GUCY2C
    Novus Biologicals GUCY2C Antibodies
    Abcam antibodies for GUCY2C
    Cloud-Clone Corp. Antibodies for GUCY2C
    ThermoFisher Antibodies for GUCY2C
    LSBio Antibodies in human, mouse, rat for GUCY2C

    GUCY2C Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GUCY2C
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GUCY2C
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GUCY2C
    Cloud-Clone Corp. CLIAs for GUCY2C
    Search eBioscience for ELISAs for GUCY2C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: guanylate cyclase 2C (heat stable enterotoxin receptor)
    Natriuretic peptide receptor family
    Receptor Guanylate Cyclase (RGC) family

    Selected InterPro protein domains (see all 7):
     IPR028082 Peripla_BP_I
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry P25092

    ProtoNet protein and cluster: P25092

    1 Blocks protein domain: IPB001828 Extracellular ligand-binding receptor

    UniProtKB/Swiss-Prot: GUC2C_HUMAN, P25092
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 1 guanylate cyclase domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with GUCY2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GUC2C_HUMAN, P25092
    Function: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation
    of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin
    Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate

         Genatlas biochemistry entry for GUCY2C:
    guanylate cyclase C,transmembrane receptor primarily expressed in the intestine

         Enzyme Numbers (IUBMB): EC 4.6.1.21 2 EC 4.6.12

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004383guanylate cyclase activity IEA--
    GO:0004672protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11950846
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with GUCY2C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GUCY2C:
     Decreased circadian period len 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gucy2c):
     adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  growth/size/body 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with GUCY2C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GUCY2C: Gucy2ctm1Gian Gucy2ctm1Gar

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GUCY2C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GUCY2C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GUCY2C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GUCY2C

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GUCY2C using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate GUCY2C:
    hsa-miR-30c hsa-miR-30a hsa-miR-544 hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidGUCY2C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GUCY2C
    Predesigned siRNA for gene silencing in human, mouse, rat GUCY2C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GUCY2C

    Clone
    Products:
         
    OriGene clones in human, mouse for GUCY2C (see all 7)
    OriGene ORF clones in mouse, rat for GUCY2C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GUCY2C (NM_004963)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GUCY2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GUCY2C

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GUCY2C
    Browse ESI BIO Cell Lines and PureStem Progenitors for GUCY2C 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GUCY2C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GUC2C_HUMAN, P25092: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Note=The 145 kDa plasma membrane form of GC-C contains sialic acid and
    galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in
    the endoplasmic reticulum and may serve as the precursor for the cell surface form
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    extracellular3
    cytosol2
    mitochondrion2
    nucleus2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GUCY2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GUCY2C About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    2CREB Pathway
    Intracellular Calcium Signaling0.50
    3Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    4Purine metabolism (KEGG)
    Purine metabolism0.38
    5Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38


    Find genes that share SuperPaths with GUCY2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GUCY2C (see all 7)
        Cellular Effects of Sildenafil
    Sertoli-Sertoli Cell Junction Dynamics
    eNOS Signaling
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods


    1 Kegg Pathway  (Kegg details for GUCY2C):
        Purine metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GUCY2C
    Interactions:

        GeneGlobe Interaction Network for GUCY2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GUCY2C (P250921, 2, 3 ENSP000002611704) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDZK1Q5T2W12, 3, ENSP000003421434MINT-1777734 I2D: score=1 STRING: ENSP00000342143
    GUCA2AQ027473, ENSP000003494934I2D: score=1 STRING: ENSP00000349493
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    PDZD3Q86UT5-21, ENSP000003271074EBI-2816795,EBI-8299496 MINT-1773222 MINT-1777648 MINT-1777755 MINT-1777668 I2D: score=1 STRING: ENSP00000327107
    ITPAENSP000003694564STRING: ENSP00000369456
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006182cGMP biosynthetic process ----
    GO:0006468protein phosphorylation ----
    GO:0007168receptor guanylyl cyclase signaling pathway TAS1680854
    GO:0009190cyclic nucleotide biosynthetic process ----
    GO:0009636response to toxic substance IEA--

    Find genes that share ontologies with GUCY2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GUCY2C (GUC2C)

    5 HMDB Compounds for GUCY2C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for GUCY2C    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Linaclotide -- 851199-59-2targetagonist23090647

    3 IUPHAR Ligands for GUCY2C (guanylate cyclase 2C (heat stable enterotoxin receptor))    About this table
    LigandTypeActionAffinityPubmed IDs
    linaclotide
    AgonistAgonist17694454
    E. coli heat-stable enterotoxin (STa)
    AgonistAgonist--
    [125I]Sta
    NoneNone--

    10 Novoseek inferred chemical compound relationships for GUCY2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    enterotoxin 91.3 47 1718270 (2), 11931628 (2), 1701694 (2), 8797807 (1) (see all 41)
    cgmp 71.4 12 15937149 (2), 9516400 (2), 1680854 (1), 9188791 (1) (see all 9)
    2 chloroadenosine 44.9 3 8995360 (2)
    guanylate 38.1 3 1718270 (1), 8096619 (1)
    paraffin 22.6 2 12763211 (1), 16049286 (1)
    chloride 14.7 1 10224234 (1)
    atp 6.94 1 11478887 (1)
    magnesium 0 1 15937149 (1)
    calcium 0 5 15937149 (5)
    tyrosine 0 3 11120586 (1)



    Find genes that share compounds with GUCY2C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GUCY2C gene: 
    NM_004963.3  

    Unigene Cluster for GUCY2C:

    Guanylate cyclase 2C (heat stable enterotoxin receptor)
    Hs.524278  [show with all ESTs]
    Unigene Representative Sequence: NM_004963
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261170(uc001rcd.3) ENST00000535803(uc009zhz.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GUCY2C using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate GUCY2C:
    hsa-miR-30c hsa-miR-30a hsa-miR-544 hsa-miR-30b hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidGUCY2C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GUCY2C
    Predesigned siRNA for gene silencing in human, mouse, rat GUCY2C
    Clone
    Products:
         
    OriGene clones in human, mouse for GUCY2C (see all 7)
    OriGene ORF clones in mouse, rat for GUCY2C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GUCY2C (NM_004963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GUCY2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GUCY2C
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GUCY2C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GUCY2C
      QuantiTect SYBR Green Assays in human, mouse, rat GUCY2C
      QuantiFast Probe-based Assays in human, mouse, rat GUCY2C

    Additional mRNA sequence: 

    AK310034.1 BC136544.1 BC136545.1 M73489.1 S57551.1 

    3 DOTS entries:

    DT.409598  DT.95266495  DT.97781094 

    Selected AceView cDNA sequences (see all 29):

    AI357407 AW376842 M73489 NM_004963 AI832359 AW848739 BM746765 AI446632 
    BX480883 AW578382 BM765195 AI732333 S57551 BX480841 AA514592 AA129983 
    AW362865 AW779607 BX483321 BF756855 AA524004 BG982246 AW859797 AW848810 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GUCY2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCAGATGT
    GUCY2C Expression
    About this image


    GUCY2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Amygdala
     
     Colon (Gastrointestinal Tract)
    GUCY2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GUCY2C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524278
        Custom PCR Arrays for GUCY2C
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GUCY2C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GUCY2C
    QuantiTect SYBR Green Assays in human, mouse, rat GUCY2C
    QuantiFast Probe-based Assays in human, mouse, rat GUCY2C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GUCY2C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GUCY2C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gucy2c1 , 5 guanylate cyclase 2c1, 5 81.19(n)1
    82.42(a)1
      6 (66.67 cM)5
    149171  NM_001127318.11  NP_001120790.11 
     1366972855 
    chicken
    (Gallus gallus)
    Aves GUCY2C1 guanylate cyclase 2C (heat stable enterotoxin receptor) 70.31(n)
    68.47(a)
      417968  XM_416207.4  XP_416207.3 
    lizard
    (Anolis carolinensis)
    Reptilia GUCY2C6
    guanylate cyclase 2C (heat stable enterotoxin rece...
    73(a)
    1 ↔ 1
    GL343714.1(336-58101)
    African clawed frog
    (Xenopus laevis)
    Amphibia gucy2c-A2 guanylate cyclase 2C (heat stable enterotoxin receptor) 77.7(n)    D49837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5720521 heat-stable enterotoxin receptor-like 60.18(n)
    57.61(a)
      572052  XM_695711.6  XP_700803.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57193 guanylate cyclase 52(a)   55B12   --
    worm
    (Caenorhabditis elegans)
    Secernentea gcy-43 guanylate cyclase 38(a)
    (best of 8)
      II(10304047-10308764)   --


    ENSEMBL Gene Tree for GUCY2C (if available)
    TreeFam Gene Tree for GUCY2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GUCY2C gene
    ADCY52  ADCY22  GUCY2D2  NPR12  ADCY82  GUCY2F2  GUCY1A22  ADCY72  
    ADCY92  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    3 SIMAP similar genes for GUCY2C using alignment to 2 protein entries:     GUC2C_HUMAN (see all proteins):
    NPR1    ADCY4    NPR2

    Find genes that share paralogs with GUCY2C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GUCY2C (see all 1757)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0681744
    Meconium ileus (MECIL)4--see VAR_0681742 D G mis40--------
    VAR_0677244
    Diarrhea 6 (DIAR6)4--see VAR_0677242 S I mis40--------
    VAR_0422224
    A metastatic melanoma sample4--see VAR_0422222 G R mis40--------
    rs346296081,2
    C--14561564(+) GTCTC-/A/AA  
            
    AAAAA
    1 -- int11NA 2
    rs1877623691,2
    --14765194(+) GGTGGA/CGCAGT 1 -- int10--------
    rs1423973801,2
    --14765211(+) TGAAGA/TGAGTA 1 -- int10--------
    rs1513326261,2
    C--14765255(+) AGCCTG/TGAGAC 1 -- int10--------
    rs1166949011,2
    F--14765266(+) ATGGAT/ATACTT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1911236601,2
    --14765316(+) CTGGGC/TCCCAT 1 -- int10--------
    rs1406008161,2
    --14765319(+) GGTCCC/TATACT 1 -- int10--------

    HapMap Linkage Disequilibrium report for GUCY2C (14765566 - 14849519 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GUCY2C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528779CNV Loss19592680
    nsv898817CNV Gain21882294

    Human Gene Mutation Database (HGMD): GUCY2C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GUCY2C
    DNA2.0 Custom Variant and Variant Library Synthesis for GUCY2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601330   
    OMIM disorders: 614616  614665  
    UniProtKB/Swiss-Prot: GUC2C_HUMAN, P25092
  • Diarrhea 6 (DIAR6) [MIM:614616]: A relatively mild, early-onset chronic diarrhea that may be associated
    with increased susceptibility to inflammatory bowel disease, small bowel obstruction, and esophagitis. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Meconium ileus (MECIL) [MIM:614665]: A condition characterized by a intestinal obstruction due to
    inspissated meconium in the distal ileum and cecum, which develops in utero and presents shortly after birth as a
    failure to pass meconium. Meconium ileus is a known clinical manifestation of cystic fibrosis. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 5 diseases for GUCY2C:    
    About MalaCards
    meconium ileus    chronic diarrhea due to guanylate cyclase 2c overactivity    ileus    ovarian mucinous neoplasm
    diarrhea

    7 diseases from the University of Copenhagen DISEASES database for GUCY2C:
    Hypertension     cone-rod dystrophy     Leber congenital amaurosis     Constipation
    Irritable bowel syndrome     Diarrhea     Heart disease

    Find genes that share disorders with GUCY2C           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GUCY2C gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal tumors 74.4 4 8962140 (1), 15937149 (1), 16149873 (1), 17155897 (1)
    colorectal cancer 66.8 28 9514425 (3), 10206298 (2), 10711442 (2), 19800103 (2) (see all 20)
    colon carcinoma 58.7 9 11438734 (2), 7654763 (2), 8962140 (1), 15937149 (1) (see all 6)
    colon cancer 52.5 8 15937149 (2), 9514425 (1), 15264876 (1), 16731751 (1) (see all 7)
    colorectal carcinoma 47.1 6 19800103 (4), 15754294 (1), 18615494 (1)
    metastasis 41.8 5 19537845 (1), 12163327 (1), 12763211 (1), 19800103 (1) (see all 5)
    metaplasia 39.9 2 15754294 (1), 12831335 (1)
    histopathology 38.3 3 9514425 (2), 20498026 (1)
    neoplastic transformation 33.5 1 17687268 (1)
    adenocarcinoma 26 5 15754294 (2), 11884500 (1), 12163327 (1), 12831335 (1)


    Export disorders for GUCY2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GUCY2C gene, integrated from 10 sources (see all 145):
    (articles sorted by number of sources associating them with GUCY2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin. (PubMed id 1680854)1, 2, 9 de Sauvage F.J.... Goeddel D.V. (J. Biol. Chem. 1991)
    2. Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line. (PubMed id 1718270)1, 2, 9 Singh S.... Gerzer R. (Biochem. Biophys. Res. Commun. 1991)
    3. Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin receptor gene. (PubMed id 8605253)1, 2, 9 Mann E.A.... Giannella R.A. (Biochim. Biophys. Acta 1996)
    4. Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36. (PubMed id 23269669)1, 2 Arshad N.... Visweswariah S.S. (J. Biol. Chem. 2013)
    5. Meconium ileus caused by mutations in GUCY2C, encoding the CFTR- activating guanylate cyclase 2C. (PubMed id 22521417)1, 2 Romi H....Birk O.S. (Am. J. Hum. Genet. 2012)
    6. Familial diarrhea syndrome caused by an activating GUCY2C mutation. (PubMed id 22436048)1, 2 Fiskerstrand T.... Knappskog P.M. (N. Engl. J. Med. 2012)
    7. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. (PubMed id 11950846)1, 2 Scott R.O.... Milgram S.L. (J. Biol. Chem. 2002)
    8. Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12. (PubMed id 8661067)1, 3 Mann E.A....Giannella R.A. (Genomics 1996)
    9. Comparison of receptors for Escherichia coli heat-stable enterotoxin: novel receptor present in IEC-6 cells. (PubMed id 8381596)1, 2 Mann E.A.... Giannella R.A. (Am. J. Physiol. 1993)
    10. Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms. (PubMed id 19694825)1, 9 Ciocca V....Waldman S.A. (Histopathology 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2984 HGNC: 4688 AceView: GUCY2C Ensembl:ENSG00000070019 euGenes: HUgn2984
    ECgene: GUCY2C Kegg: 2984 H-InvDB: GUCY2C

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GUCY2C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GUCY2C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GUCY2C gene:
    Search GeneIP for patents involving GUCY2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GUCY2C  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GUCY2C  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GUCY2C  
     OriGene qSTAR qPCR primer pairs in human, mouse for GUCY2C   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GUCY2C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GUCY2C   OriGene Custom Protein Services for GUCY2C  

     
     
     Block miRNA regulation of human, mouse, rat GUCY2C using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GUCY2C
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GUCY2C Predesigned siRNA for gene silencing in human, mouse, rat GUCY2C
     QuantiFast Probe-based Assays in human, mouse, rat GUCY2C QuantiTect SYBR Green Assays in human, mouse, rat GUCY2C
     Custom PCR Arrays for GUCY2C Search Chromatin IP Primers for GUCY2C
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GUCY2C  GeneGlobe Interaction Network for GUCY2C
     Regulatory tfbs in GUCY2C promoter
     GenScript Custom Purified and Recombinant Proteins Services for GUCY2C GenScript cDNA clones with any tag delivered in your preferred vector for GUCY2C
     GenScript Custom Assay Services for GUCY2C GenScript Custom overexpressing Cell Line Services for GUCY2C
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GUCY2C (GUC2C)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GUCY2C antibodies
     GUCY2C proteins
     GUCY2C lysates
     Antibodies for GUCY2C
     See all of Abcam's Antibodies, Kits and Proteins for GUCY2C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GUCY2C
     Antibodies for GUCY2C
     ELISAs for GUCY2C
     CLIAs for GUCY2C



     Browse ESI BIO Cell Lines and PureStem Progenitors for GUCY2C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GUCY2C
     SwitchGear 3'UTR luciferase reporter plasmids for GUCY2C
     SwitchGear Promoter luciferase reporter plasmids for GUCY2C
     ThermoFisher Antibodies for GUCY2C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GUCY2C
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GUCY2C
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GUCY2C
     LSBio Antibodies in human, mouse, rat for GUCY2C
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for GUCY2C
      Search eBioscience for proteins for GUCY2C
      Search eBioscience for elisas for GUCY2C
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GUCY2C gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4