Aliases for GUCY1B3 Gene
External Ids for GUCY1B3 Gene
Previous HGNC Symbols for GUCY1B3 Gene
Previous GeneCards Identifiers for GUCY1B3 Gene
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
GeneCards Summary for GUCY1B3 Gene
GUCY1B3 (Guanylate Cyclase 1, Soluble, Beta 3) is a Protein Coding gene. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein heterodimerization activity and receptor activity. An important paralog of this gene is ADCY5.
Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases. There are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.