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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GUCY1B3 Gene

protein-coding   GIFtS: 64
GCID: GC04P156680

guanylate cyclase 1, soluble, beta 3


(Previous symbol: GUC1B3)
 Explore 1 disease affiliated with
GUCY1B3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GUCY1B3    

Aliases
for GUCY1B3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Guanylate Cyclase 1, Soluble, Beta 31 2     GCS-Beta-11
GUC1B31 2 3 5     GCS-Beta-31
GUCSB32 3 5     GUCY1B12 3
GC-S-Beta-11     EC 4.6.1.23 8
GC-SB31 2     GUCB32
Guanylate Cyclase Soluble Subunit Beta-32 3     Guanylate Cyclase Soluble Subunit Beta-12
Soluble Guanylate Cyclase Small Subunit2 3     

External Ids:    HGNC: 46871   Entrez Gene: 29832   Ensembl: ENSG000000619187   OMIM: 1393975   UniProtKB: Q021533   

Export aliases for GUCY1B3 gene to outside databases

Previous GC identifers: GC04P157568 GC04P157108 GC04P157257 GC04P157246 GC04P157037 GC04P156888 GC04P152419


Summaries
for GUCY1B3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GUCY1B3:
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically
GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide
(NO) and nitrovasodilator drugs (Zabel et al., 1998 (PubMed 9742212)).(supplied by OMIM, Mar 2008)

summary for GUCY1B3:
Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or
Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate.
The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the
conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases. There
are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and
transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for
guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix
production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important
communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.

Gene Wiki entry for GUCY1B3


Genomic Views
for GUCY1B3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GUCY1B3 gene promoter:
         Egr-3   ER-alpha   Sp1   HSF1 (long)   Gfi-1   POU2F1   GATA-6   HSF1short   Msx-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GUCY1B3 promoter sequence
   Search SABiosciences Chromatin IP Primers for GUCY1B3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GUCY1B3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3-q33   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31.3-q33

GUCY1B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GUCY1B3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P156680:  view genomic region     (about GC identifiers)

Start:
 156,680,126 bp from pter      End:
 156,728,783 bp from pter
Size:
 48,658 bases      Orientation:
 plus strand

Proteins
for GUCY1B3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GCYB1_HUMAN, Q02153 (See protein sequence)
Recommended Name: Guanylate cyclase soluble subunit beta-1  
Size: 619 amino acids; 70514 Da
Cofactor: Binds 1 or 2 heme groups per heterodimer (By similarity)
Subunit: Heterodimer of an alpha and a beta chain
Subcellular location: Cytoplasm
Miscellaneous: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms
2 PDB 3D structures from and Proteopedia for GUCY1B3:
2WZ1 (3D)        3UVJ (3D)    
Secondary accessions: Q86WY5
Alternative splicing: 2 isoforms:  Q02153-1   Q02153-2   

Explore the universe of human proteins at neXtProt for GUCY1B3: NX_Q02153

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02153

    • 4/7 DME Specific Peptides for GUCY1B3 (Q02153) (see all 7)
     LKGQMIY  LLNDLYT  GESVQIT  MPRYCLFG 

    GUCY1B3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000848.1  
    ENSEMBL proteins: 
     ENSP00000427226   ENSP00000426786   ENSP00000426319   ENSP00000422313   ENSP00000264424  
     ENSP00000420842   ENSP00000425065  
    Reactome Protein details: Q02153
    Human Recombinant Protein Products: 
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    Enzo Life Sciences proteins for GUCY1B3
    OriGene Purified Protein: GUCY1B3
    OriGene Protein Over-expression Lysate: GUCY1B3
    OriGene Custom Protein Services for GUCY1B3 
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    Novus Biologicals GUCY1B3 Protein
    Novus Biologicals GUCY1B3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0008074guanylate cyclase complex, soluble IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--
    GO:0043234protein complex ----


    GUCY1B3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for GUCY1B3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GUCY1B3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011644 Heme_NO-bd
     IPR024096 NO_sig/Golgi_transp_ligand-bd
     IPR011645 Haem_no_assoc-bd
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry Q02153

    ProtoNet protein and cluster: Q02153

    1 Blocks protein family: IPB011644 Heme NO binding

    UniProtKB/Swiss-Prot: GCYB1_HUMAN, Q02153
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 1 guanylate cyclase domain


    Function
    for GUCY1B3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GCYB1_HUMAN, Q02153
    Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate
    Enzyme regulation: Activated by nitric oxide in the presence of magnesium or manganese ions

         Genatlas biochemistry entry for GUCY1B3:
    guanylate cyclase,soluble,beta-1 subunit,73kDa,heterodimerizing with GUCY1A3,preferentially expressed in lung and brain

    Enzyme Number (IUBMB): EC 4.6.1.21 2

    miRNA
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    hsa-miR-142-5p hsa-miR-361-5p hsa-miR-340 hsa-miR-483-3p hsa-miR-4314 hsa-miR-877* hsa-miR-466 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmid: GUCY1B3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GUCY1B3 (see all 7)
    OriGene shRNA RFP: GUCY1B3
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GUCY1B3

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GUCY1B3 (see all 4)
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004383guanylate cyclase activity IEA--
    GO:0004872receptor activity TAS9742212
    GO:0005525GTP binding IEA--
    GO:0020037heme binding IEA--


    GUCY1B3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Gucy1b3tm1.1Frb for GUCY1B3
         13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gucy1b3):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  nervous system  normal 

    GUCY1B3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GUCY1B3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nitric oxide stimulates guanylate cyclase
    		Nitric oxide stimulates guanylate cyclase1.00
    		Platelet homeostasis0.34
    2Signaling in Gap Junctions
    		Signaling in Gap Junctions1.00
    		Gap junction0.31
    3Development Angiotensin activation of ERK
    		Development EDNRB signaling0.54
    		Development_EDNRB signaling0.54
    4G-Beta Gamma Signaling
    		CRHR Pathway0.44
    		Relaxin Pathway0.32
    5Sweet Taste Signaling
    		Cellular Effects of Sildenafil0.46
    		Sperm Motility0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for GUCY1B3
        Development EDNRB signaling
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GUCY1B3 (see all 10)
        Sertoli-Sertoli Cell Junction Dynamics
    Relaxin Pathway
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CRHR Pathway

    3 GeneGo (Thomson Reuters) Pathways for GUCY1B3
        Development EDNRB signaling
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
    NO-dependent CFTR activation (normal and CF)

    3        Reactome Pathways for GUCY1B3
        Hemostasis
    Platelet homeostasis
    Nitric oxide stimulates guanylate cyclase


    5         Kegg Pathways  (Kegg details for GUCY1B3):
        Purine metabolism
    Vascular smooth muscle contraction
    Gap junction
    Long-term depression
    Salivary secretion


    GUCY1B3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GUCY1B3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/81 Interacting proteins for GUCY1B3 (Q021533 ENSP000002644244) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GUCY1A2P334023, ENSP000003448744I2D: score=2 STRING: ENSP00000344874
    STUB1Q9UNE73, ENSP000002195484I2D: score=1 STRING: ENSP00000219548
    AGAP1Q9UPQ33, ENSP000003076344I2D: score=1 STRING: ENSP00000307634
    HSP90AA1P079003, ENSP000003351534I2D: score=2 STRING: ENSP00000335153
    NOS3P294743, ENSP000002974944I2D: score=1 STRING: ENSP00000297494
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006182cGMP biosynthetic process ----
    GO:0007263nitric oxide mediated signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0008015blood circulation TAS9742212
    GO:0035556intracellular signal transduction ----


    GUCY1B3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GUCY1B3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for GUCY1B3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GUCY1B3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BPIPPNon-competitive GC inhibitor. Also AC inhibitor[325746-94-9]
    A 350619 hydrochlorideSoluble guanylyl cyclase (sGC) activator[538368-27-3]
    CFM 1571 hydrochlorideSoluble guanylyl cyclase (sGC) activator[268725-86-6]
    YC 1Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest[170632-47-0]
    BAY 41-2272Soluble guanylyl cyclase (sGC) activator[256376-24-6]

    7 HMDB Compounds for GUCY1B3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about GUCY1B3 / GCYB1 

    Transcripts
    for GUCY1B3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GUCY1B3 gene: 
    NM_000857.2  

    Unigene Cluster for GUCY1B3:

    Guanylate cyclase 1, soluble, beta 3
    Hs.77890  [show with all ESTs]
    Unigene Representative Sequence: NM_000857
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505154 ENST00000502959 ENST00000505764 ENST00000507146 ENST00000264424(uc003ipc.3 uc011cio.2 uc011cip.2 uc003ipd.3 uc010iqf.3 uc010iqg.3 uc011ciq.2)
    ENST00000503520 ENST00000513437

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    hsa-miR-142-5p hsa-miR-361-5p hsa-miR-340 hsa-miR-483-3p hsa-miR-4314 hsa-miR-877* hsa-miR-466 hsa-miR-3143
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF020340.1 AK296680.1 AK299916.1 AK300296.1 AK307838.1 AK315199.1 AK315944.1 BC026332.1 
    BC047620.1 BC060835.1 X66533.1 

    9 DOTS entries:

    DT.95271315  DT.40116559  DT.101980845  DT.100721747  DT.100814170  DT.121232549  DT.92424574  DT.97858588 
    DT.99981227 

    24/127 AceView cDNA sequences (see all 127):

    AL548673 AA291938 BX393850 CA392331 CA389729 BC060835 AF020340 BM126339 
    AI870690 AL713444 BM673988 AI784630 AA932013 AW271616 BP361399 BF593579 
    AA419138 BM701121 W73204 BI916583 H86484 BG166632 F02745 AI189698 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1B3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                -                 -     -                                                                                       
    SP2:                                -                 -     -                                               -                                       
    SP3:                                -                 -     -     -                                                                                 
    SP4:                          -     -                 -                                                                                             
    SP5:                          -     -                 -     -                                                                                       


    ECgene alternative splicing isoforms for GUCY1B3

    Expression
    for GUCY1B3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GUCY1B3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAATGTGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GUCY1B3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    EyeLensEye
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GUCY1B3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GUCY1B3

    SOURCE GeneReport for Unigene cluster: Hs.77890
        SABiosciences Expression via Pathway-Focused PCR Arrays including GUCY1B3: 
              Hypertension in human mouse rat
              Gap Junctions in human mouse rat

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    Orthologs
    for GUCY1B3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GUCY1B3 gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GUCY1B31 guanylate cyclase 1, soluble, beta 3 83.98(n)
    97.56(a)    		   422408  XM_420376.3  XP_420376.3 
    lizard
    (Anolis carolinensis)    		 Reptilia GUCY1B36
    		 --
    		 96(a)
    		 1 ↔ 1
    		 5(129500596-129538441)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BG814851.12   -- 81.25(n)    BG814851.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gucy1b31 guanylate cyclase 1, soluble, beta 3 77.21(n)
    89.62(a)    		   100150304  XM_001920228.2  XP_001920263.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Gyc&bgr;100B3
    Gycbeta100B1    		 cGMP biosynthesis guanylate cyclase3
    Guanylyl cyclase beta-subunit at 100B1    		 58(a)
    (best of 4)3
    58.57(n)1
    61.65(a)1    		   436821  NM_079864.31  NP_524603.21 


    ENSEMBL Gene Tree for GUCY1B3 (if available)
    TreeFam Gene Tree for GUCY1B3 (if available) 

    Paralogs
    for GUCY1B3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GUCY1B3 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  GUCY2F2  ADCY82  GUCY1A22  
    ADCY72  ADCY92  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    7 SIMAP similar genes for GUCY1B3 using alignment to 5 protein entries:     GCYB1_HUMAN (see all proteins):
    NPR2    NPR1    ADCY5    GUCY1A2    GUCY1A3    ADCY4
    GUCY1B2

    GUCY1B3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GUCY1B3
    PGOHUM00000257955


    Genomic Variants
    for GUCY1B3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for GUCY1B3
         1 CNV: 9497
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for GUCY1B3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GUCY1B3 for disorders           About GeneDecksing

    OMIM gene information: 139397    OMIM disorders: --

    1 disease for GUCY1B3:    About MalaCards
    retinitis


    Export disorders for GUCY1B3 gene to outside databases

    Publications
    for GUCY1B3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GUCY1B3 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with GUCY1B3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. (PubMed id 1352257)1, 2, 3 Giuili G.... Guellaeen G. (1992)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Heterogeneity in human soluble guanylate cyclase due to alternative splicing. (PubMed id 1680753)1, 2 Chhajilani V....Wikberg J.E.S. (1991)
    4. Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction. (PubMed id 16528291)1, 9 Mateos-Caceres P.J....Lopez-Farre A.J. (2006)
    5. Structural and functional insights into the heme-bindi ng domain of the human soluble guanylate cyclase a2 subunit and heterodimeric a2 b1. (PubMed id 22426988)1 Wang H....Tan X. (2012)
    6. Quaternary structure controls ligand dynamics in solub le guanylate cyclase. (PubMed id 22223482)1 Yoo B.K....Negrerie M. (2012)
    7. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase. (PubMed id 22690686)1 Chauhan S....Martin E. (2012)
    8. Fluorescence dequenching makes haem-free soluble guan ylate cyclase detectable in living cells. (PubMed id 21858179)1 Hoffmann L.S....Stasch J.P. (2011)
    9. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1 Wain L.V....van Duijn C.M. (2011)
    10. Genetic variants in novel pathways influence blood pre ssure and cardiovascular disease risk. (PubMed id 21909115)1  ....Johnson T. (2011)

    External Searches for GUCY1B3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GUCY1B3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2983 HGNC: 4687 AceView: GUCY1B3 Ensembl:ENSG00000061918 euGenes: HUgn2983
    ECgene: GUCY1B3 Kegg: 2983 H-InvDB: GUCY1B3

    Other Databases showing GUCY1B3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GUCY1B3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GUCY1B3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GUCY1B3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GUCY1B3 gene:
    Search GeneIP for patents involving GUCY1B3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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