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GUCY1B3 Gene

protein-coding   GIFtS: 64
GCID: GC04P156680

Guanylate Cyclase 1, Soluble, Beta 3


(Previous symbol: GUC1B3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanylate Cyclase 1, Soluble, Beta 31 2     GUCY1B12 3
GUC1B31 2 3 5     EC 4.6.1.23 8
GUCSB32 3 5     GC-S-beta-12
Guanylate Cyclase Soluble Subunit Beta-32 3     GC-SB32
Soluble Guanylate Cyclase Small Subunit2 3     GUCB32
GCS-beta-12 3     Guanylate Cyclase Soluble Subunit Beta-12
GCS-beta-32 3     

External Ids:    HGNC: 46871   Entrez Gene: 29832   Ensembl: ENSG000000619187   OMIM: 1393975   UniProtKB: Q021533   

Export aliases for GUCY1B3 gene to outside databases

Previous GC identifers: GC04P157568 GC04P157108 GC04P157257 GC04P157246 GC04P157037 GC04P156888 GC04P152419


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GUCY1B3 Gene:
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit,
typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor
for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 (PubMed 9742212)).(supplied by OMIM, Mar
2008)

GeneCards Summary for GUCY1B3 Gene:
GUCY1B3 (guanylate cyclase 1, soluble, beta 3) is a protein-coding gene. GO annotations related to this gene include receptor activity and protein heterodimerization activity. An important paralog of this gene is ADCY5.

summary for GUCY1B3 Gene:
Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or
Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate.
The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the
conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases. There
are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and
transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for
guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix
production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important
communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.

Gene Wiki entry for GUCY1B3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GUCY1B3 gene promoter:
         Egr-3   ER-alpha   Sp1   HSF1 (long)   Gfi-1   POU2F1   GATA-6   HSF1short   Msx-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGUCY1B3 promoter sequence
   Search Chromatin IP Primers for GUCY1B3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GUCY1B3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3-q33   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31.3-q33

GUCY1B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GUCY1B3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P156680:  view genomic region     (about GC identifiers)

Start:
156,680,126 bp from pter      End:
156,728,783 bp from pter
Size:
48,658 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GCYB1_HUMAN, Q02153 (See protein sequence)
Recommended Name: Guanylate cyclase soluble subunit beta-1  
Size: 619 amino acids; 70514 Da
Cofactor: Binds 1 or 2 heme groups per heterodimer (By similarity)
Subunit: Heterodimer of an alpha and a beta chain
Miscellaneous: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms
2 PDB 3D structures from and Proteopedia for GUCY1B3:
2WZ1 (3D)        3UVJ (3D)    
Secondary accessions: Q86WY5
Alternative splicing: 2 isoforms:  Q02153-1   Q02153-2   

Explore the universe of human proteins at neXtProt for GUCY1B3: NX_Q02153

Explore proteomics data for GUCY1B3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GUCY1B3 (Q02153) (see all 7)
     LKGQMIY  LLNDLYT  GESVQIT  MPRYCLFG 


    See GUCY1B3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000848.1  
    ENSEMBL proteins: 
     ENSP00000427226   ENSP00000426786   ENSP00000426319   ENSP00000422313   ENSP00000264424  
     ENSP00000420842   ENSP00000425065  
    Reactome Protein details: Q02153

    GUCY1B3 Human Recombinant Protein Products:

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    Novus Biologicals GUCY1B3 Protein
    Novus Biologicals GUCY1B3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GUCY1B3 

     
    antibodies-online proteins for GUCY1B3 (4 products) 

     
    antibodies-online peptides for GUCY1B3

    GUCY1B3 Antibody Products:

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    antibodies-online antibodies for GUCY1B3 (36 products) 

    GUCY1B3 Assay Products:

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    antibodies-online kits for GUCY1B3 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Soluble guanylyl cyclase beta 1 subunit
    Soluble guanylyl cyclase

    5 InterPro protein domains:
     IPR011644 Heme_NO-bd
     IPR024096 NO_sig/Golgi_transp_ligand-bd
     IPR011645 Haem_no_assoc-bd
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry Q02153

    ProtoNet protein and cluster: Q02153

    1 Blocks protein domain: IPB011644 Heme NO binding

    UniProtKB/Swiss-Prot: GCYB1_HUMAN, Q02153
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 1 guanylate cyclase domain


    Find genes that share domains with GUCY1B3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCYB1_HUMAN, Q02153
    Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate
    Enzyme regulation: Activated by nitric oxide in the presence of magnesium or manganese ions

         Genatlas biochemistry entry for GUCY1B3:
    guanylate cyclase,soluble,beta-1 subunit,73kDa,heterodimerizing with GUCY1A3,preferentially expressed in lung and
    brain

         Enzyme Number (IUBMB): EC 4.6.1.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004383guanylate cyclase activity IEA--
    GO:0004872receptor activity TAS9742212
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with GUCY1B3           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gucy1b3):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  nervous system  normal 

    Find genes that share phenotypes with GUCY1B3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gucy1b3tm1.1Frb for GUCY1B3

       genOway: Develop your customized and physiologically relevant rodent model for GUCY1B3

    miRNA
    Products:
        
    miRTarBase miRNAs that target GUCY1B3:
    hsa-mir-186-5p (MIRT045241)

    Block miRNA regulation of human, mouse, rat GUCY1B3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GUCY1B3 (see all 11):
    hsa-miR-142-5p hsa-miR-361-5p hsa-miR-340 hsa-miR-483-3p hsa-miR-4314 hsa-miR-877* hsa-miR-466 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidGUCY1B3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat GUCY1B3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: GUCY1B3 (NM_000857)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GUCY1B3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GUCY1B3
    Addgene plasmids for GUCY1B3 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GUCY1B3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GCYB1_HUMAN, Q02153: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0008074guanylate cyclase complex, soluble IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--
    GO:0043234protein complex ----

    Find genes that share ontologies with GUCY1B3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GUCY1B3 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    2G-Beta Gamma Signaling
    CRHR Pathway0.44
    Relaxin Pathway0.37
    3Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    4Oxytocin signaling pathway
    Oxytocin signaling pathway0.32
    Vascular smooth muscle contraction0.32
    5Development Angiotensin activation of ERK
    Development EDNRB signaling0.54


    Find genes that share SuperPaths with GUCY1B3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GUCY1B3 (see all 10)
        Sertoli-Sertoli Cell Junction Dynamics
    Relaxin Pathway
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CRHR Pathway

    3 GeneGo (Thomson Reuters) Pathways for GUCY1B3
        Development EDNRB signaling
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
    NO-dependent CFTR activation (normal and CF)

    1 Reactome Pathway for GUCY1B3
        Nitric oxide stimulates guanylate cyclase


    Selected Kegg Pathways  (Kegg details for GUCY1B3) (see all 7):
        Purine metabolism
    Vascular smooth muscle contraction
    Gap junction
    Circadian entrainment
    Long-term depression

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GUCY1B3: 
              Hypertension in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GUCY1B3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GUCY1B3 (Q021533 ENSP000002644244) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GUCY1A2P334023, ENSP000003448744I2D: score=2 STRING: ENSP00000344874
    STUB1Q9UNE73, ENSP000002195484I2D: score=1 STRING: ENSP00000219548
    AGAP1Q9UPQ33, ENSP000003076344I2D: score=1 STRING: ENSP00000307634
    HSP90AA1P079003, ENSP000003351534I2D: score=2 STRING: ENSP00000335153
    NOS3P294743, ENSP000002974944I2D: score=1 STRING: ENSP00000297494
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006182cGMP biosynthetic process ----
    GO:0007263nitric oxide mediated signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0008015blood circulation TAS9742212
    GO:0009190cyclic nucleotide biosynthetic process ----

    Find genes that share ontologies with GUCY1B3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GUCY1B3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    A 350619 hydrochlorideSoluble guanylyl cyclase (sGC) activator[538368-27-3]
    Zinc protoporphyrin IXHeme oxygenase and guanylyl cyclase inhibitor[15442-64-5]
    NS 2028Potent soluble guanylyl cyclase (sGC) inhibitor[204326-43-2]
    YC 1Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest[170632-47-0]
    BAY 41-2272Soluble guanylyl cyclase (sGC) activator[256376-24-6]

    7 HMDB Compounds for GUCY1B3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GUCY1B3 gene: 
    NM_000857.2  

    Unigene Cluster for GUCY1B3:

    Guanylate cyclase 1, soluble, beta 3
    Hs.77890  [show with all ESTs]
    Unigene Representative Sequence: NM_000857
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505154 ENST00000502959 ENST00000505764 ENST00000507146 ENST00000264424(uc003ipc.3 uc011cio.2 uc011cip.2 uc003ipd.3 uc010iqf.3 uc010iqg.3 uc011ciq.2)
    ENST00000503520 ENST00000513437
    miRNA
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    hsa-miR-142-5p hsa-miR-361-5p hsa-miR-340 hsa-miR-483-3p hsa-miR-4314 hsa-miR-877* hsa-miR-466 hsa-miR-3143
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      QuantiTect SYBR Green Assays in human, mouse, rat GUCY1B3
      QuantiFast Probe-based Assays in human, mouse, rat GUCY1B3

    Additional mRNA sequence: 

    AF020340.1 AK296680.1 AK299916.1 AK300296.1 AK307838.1 AK315199.1 AK315944.1 BC026332.1 
    BC047620.1 BC060835.1 X66533.1 

    9 DOTS entries:

    DT.95271315  DT.40116559  DT.101980845  DT.100721747  DT.100814170  DT.121232549  DT.92424574  DT.97858588 
    DT.99981227 

    Selected AceView cDNA sequences (see all 127):

    BC026332 BI916583 F02745 CA392331 AA932013 BM673988 AI189698 CA389729 
    BX393850 BM701121 BP361164 AI784630 BM126339 BM715525 AW271616 BP361399 
    CK818944 AA291938 W73204 AA971490 AW118143 BP346271 BM931417 AA419138 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1B3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                -                 -     -                                                                                       
    SP2:                                -                 -     -                                               -                                       
    SP3:                                -                 -     -     -                                                                                 
    SP4:                          -     -                 -                                                                                             
    SP5:                          -     -                 -     -                                                                                       


    ECgene alternative splicing isoforms for GUCY1B3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GUCY1B3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATGTGTA
    GUCY1B3 Expression
    About this image


    GUCY1B3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
             Lens
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
    GUCY1B3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GUCY1B3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77890
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GUCY1B3: 
              Hypertension in human mouse rat
              Gap Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GUCY1B3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gucy1b31 , 5 guanylate cyclase 1, soluble, beta 31, 5 88.69(n)1
    98.87(a)1
      3 (35.97 cM)5
    541951  NM_017469.41  NP_059497.11 
     820320045 
    chicken
    (Gallus gallus)
    Aves GUCY1B31 guanylate cyclase 1, soluble, beta 3 83.98(n)
    97.56(a)
      422408  XM_420376.4  XP_420376.3 
    lizard
    (Anolis carolinensis)
    Reptilia GUCY1B36
    guanylate cyclase 1, soluble, beta 3
    97(a)
    1 ↔ 1
    5(129497793-129574717)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG814851.12   -- 81.25(n)    BG814851.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gucy1b31 guanylate cyclase 1, soluble, beta 3 77.21(n)
    89.62(a)
      100150304  NM_001251945.1  NP_001238874.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gyc&bgr;100B3
    Gycbeta100B1
    cGMP biosynthesis guanylate cyclase3
    Guanylyl cyclase beta-subunit at 100B1
    58(a)
    (best of 4)3
    58.57(n)1
    61.65(a)1
      436821  NM_079864.31  NP_524603.21 
    worm
    (Caenorhabditis elegans)
    Secernentea gcy-313
    gcy-341
    guanylate cyclase3
    gcy-341
    36(a)
    (best of 5)3
    48.04(n)1
    39.1(a)1
      X(2456247-2457440)3
    1916561  NM_073918.51  NP_506319.11 


    ENSEMBL Gene Tree for GUCY1B3 (if available)
    TreeFam Gene Tree for GUCY1B3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GUCY1B3 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  
    ADCY72  ADCY92  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    7 SIMAP similar genes for GUCY1B3 using alignment to 5 protein entries:     GCYB1_HUMAN (see all proteins):
    NPR2    NPR1    ADCY5    GUCY1A2    GUCY1A3    ADCY4
    GUCY1B2

    Find genes that share paralogs with GUCY1B3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GUCY1B3
    PGOHUM00000257955


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GUCY1B3 (see all 980)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1827645871,2
    --156678184(+) TGGAAA/TACTAT 1 -- us2k10--------
    rs760829801,2
    F--156678207(+) AAGAAT/AAAGAT 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1879176631,2
    --156678216(+) ATCATA/GTCCTT 1 -- us2k10--------
    rs1424273421,2
    C--156678219(+) ATGTCC/TTTTGC 1 -- us2k10--------
    rs1927948851,2
    --156678224(+) CTTTGC/TATCAA 1 -- us2k10--------
    rs623270421,2
    C,F--156678226(+) TTGCAT/GCAACA 1 -- us2k17Minor allele frequency- G:0.23WA NA CSA EA 364
    rs65360911,2
    C,F--156678350(+) aagggG/Aacaat 1 -- us2k1 trp310Minor allele frequency- A:0.49NA WA CSA EA 370
    rs352064271,2
    C,F--156678355(+) GACAAT/AGACCA 1 -- us2k16Minor allele frequency- A:0.45NA EA 248
    rs1508786001,2
    --156678509(+) CATATA/GTGCCC 1 -- us2k10--------
    rs68113901,2
    C,F,A--156678511(+) tatgtA/Gcccct 1 -- us2k111Minor allele frequency- G:0.49NA WA CSA EA 371

    HapMap Linkage Disequilibrium report for GUCY1B3 (156680126 - 156728783 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GUCY1B3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521382CNV Loss19592680
    dgv5787n71CNV Loss21882294
    nsv818286CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GUCY1B3
    DNA2.0 Custom Variant and Variant Library Synthesis for GUCY1B3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139397    OMIM disorders: --


    Find genes that share disorders with GUCY1B3           About GenesLikeMe


    Export disorders for GUCY1B3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GUCY1B3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with GUCY1B3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. (PubMed id 1352257)1, 2, 3 Giuili G.... Guellaeen G. (FEBS Lett. 1992)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Heterogeneity in human soluble guanylate cyclase due to alternative splicing. (PubMed id 1680753)1, 2 Chhajilani V....Wikberg J.E.S. (FEBS Lett. 1991)
    4. Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction. (PubMed id 16528291)1, 9 Mateos-CA!ceres P.J....LA^pez-FarrAc A.J. (Int. J. Impot. Res. 2006)
    5. Subsequent gene expression pattern in dendritic cells following multiple trauma. (PubMed id 23179318)1 Geiger E.V....Henrich D. (Langenbecks Arch Surg 2013)
    6. Structural and functional insights into the heme-binding domain of the human soluble guanylate cyclase I+2 subunit and heterodimeric I+2I^1. (PubMed id 22426988)1 Wang H....Tan X. (J. Biol. Inorg. Chem. 2012)
    7. Quaternary structure controls ligand dynamics in soluble guanylate cyclase. (PubMed id 22223482)1 Yoo B.K....Negrerie M. (J. Biol. Chem. 2012)
    8. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase. (PubMed id 22690686)1 Chauhan S....Martin E. (Biochem. J. 2012)
    9. Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells. (PubMed id 21858179)1 Hoffmann L.S....Stasch J.P. (PLoS ONE 2011)
    10. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2983 HGNC: 4687 AceView: GUCY1B3 Ensembl:ENSG00000061918 euGenes: HUgn2983
    ECgene: GUCY1B3 Kegg: 2983 H-InvDB: GUCY1B3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GUCY1B3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GUCY1B3 gene:
    Search GeneIP for patents involving GUCY1B3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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