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Aliases for GUCY1B3 Gene

Aliases for GUCY1B3 Gene

  • Guanylate Cyclase 1, Soluble, Beta 3 2 3
  • GUC1B3 3 4 6
  • GUCSB3 3 4 6
  • Guanylate Cyclase Soluble Subunit Beta-3 3 4
  • Soluble Guanylate Cyclase Small Subunit 3 4
  • GCS-Beta-1 3 4
  • GCS-Beta-3 3 4
  • EC 4 63
  • GUCY1B1 3 4
  • Guanylate Cyclase Soluble Subunit Beta-1 3
  • GC-S-Beta-1 3
  • GC-SB3 3
  • GUCB3 3

External Ids for GUCY1B3 Gene

Previous HGNC Symbols for GUCY1B3 Gene

  • GUC1B3

Previous GeneCards Identifiers for GUCY1B3 Gene

  • GC04P157568
  • GC04P157108
  • GC04P157257
  • GC04P157246
  • GC04P157037
  • GC04P156888
  • GC04P156680
  • GC04P152419

Summaries for GUCY1B3 Gene

Entrez Gene Summary for GUCY1B3 Gene

  • This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for GUCY1B3 Gene

GUCY1B3 (Guanylate Cyclase 1, Soluble, Beta 3) is a Protein Coding gene. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein heterodimerization activity and receptor activity. An important paralog of this gene is ADCY5.

Tocris Summary for GUCY1B3 Gene

  • Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases. There are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.

Gene Wiki entry for GUCY1B3 Gene

No data available for UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY1B3 Gene

Genomics for GUCY1B3 Gene

Regulatory Elements for GUCY1B3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GUCY1B3 Gene

155,758,974 bp from pter
155,807,631 bp from pter
48,658 bases
Plus strand

Genomic View for GUCY1B3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GUCY1B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY1B3 Gene

Proteins for GUCY1B3 Gene

  • Protein details for GUCY1B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanylate cyclase soluble subunit beta-1
    Protein Accession:
    Secondary Accessions:
    • B7Z426
    • Q86WY5

    Protein attributes for GUCY1B3 Gene

    619 amino acids
    Molecular mass:
    70514 Da
    Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 1 or 2 heme groups per heterodimer.;
    Quaternary structure:
    • Heterodimer of an alpha and a beta chain
    • There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms

    Three dimensional structures from OCA and Proteopedia for GUCY1B3 Gene

    Alternative splice isoforms for GUCY1B3 Gene


neXtProt entry for GUCY1B3 Gene

Proteomics data for GUCY1B3 Gene at MOPED

Post-translational modifications for GUCY1B3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for GUCY1B3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  • Contains 1 guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY1B3: view

Function for GUCY1B3 Gene

Molecular function for GUCY1B3 Gene

GENATLAS Biochemistry:
guanylate cyclase,soluble,beta-1 subunit,73kDa,heterodimerizing with GUCY1A3,preferentially expressed in lung and brain
UniProtKB/Swiss-Prot CatalyticActivity:
GTP = 3,5-cyclic GMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by nitric oxide in the presence of magnesium or manganese ions

Enzyme Numbers (IUBMB) for GUCY1B3 Gene

Gene Ontology (GO) - Molecular Function for GUCY1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004383 guanylate cyclase activity IEA --
GO:0004872 receptor activity TAS 9742212
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GUCY1B3: view
genes like me logo Genes that share phenotypes with GUCY1B3: view

Animal Models for GUCY1B3 Gene

MGI Knock Outs for GUCY1B3:

Animal Model Products

miRNA for GUCY1B3 Gene

miRTarBase miRNAs that target GUCY1B3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCY1B3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for GUCY1B3 Gene

Localization for GUCY1B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY1B3 Gene


Subcellular locations from

Jensen Localization Image for GUCY1B3 Gene COMPARTMENTS Subcellular localization image for GUCY1B3 gene
Compartment Confidence
cytosol 4
cytoskeleton 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GUCY1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0008074 guanylate cyclase complex, soluble IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with GUCY1B3: view

Pathways for GUCY1B3 Gene

genes like me logo Genes that share pathways with GUCY1B3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for GUCY1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IEA --
GO:0007263 nitric oxide mediated signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0008015 blood circulation TAS 9742212
GO:0009190 cyclic nucleotide biosynthetic process --
genes like me logo Genes that share ontologies with GUCY1B3: view

Drugs for GUCY1B3 Gene

(5) Tocris Compounds for GUCY1B3 Gene

Compound Action Cas Number
A 350619 hydrochloride Soluble guanylyl cyclase (sGC) activator [1217201-17-6]
BAY 41-2272 Soluble guanylyl cyclase (sGC) activator [256376-24-6]
NS 2028 Potent soluble guanylyl cyclase (sGC) inhibitor [204326-43-2]
YC 1 Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest [170632-47-0]
Zinc protoporphyrin IX Heme oxygenase and guanylyl cyclase inhibitor [15442-64-5]

(7) HMDB Compounds for GUCY1B3 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic GMP
  • 3',5'-Cyclic GMP
Guanosine triphosphate
  • 5'-GTP
  • (protoporphyrinato)iron
  • Magnesium
  • Manganese
genes like me logo Genes that share compounds with GUCY1B3: view

Transcripts for GUCY1B3 Gene

Unigene Clusters for GUCY1B3 Gene

Guanylate cyclase 1, soluble, beta 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCY1B3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1B3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: -

Relevant External Links for GUCY1B3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GUCY1B3 Gene

mRNA expression in normal human tissues for GUCY1B3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GUCY1B3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.0).

Protein differential expression in normal tissues for GUCY1B3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.8), Platelet (9.2), Frontal cortex (8.8), and Fetal gut (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GUCY1B3 Gene

SOURCE GeneReport for Unigene cluster for GUCY1B3 Gene Hs.77890

genes like me logo Genes that share expressions with GUCY1B3: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for GUCY1B3 Gene

Orthologs for GUCY1B3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY1B3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GUCY1B3 35
  • 90.41 (n)
  • 99.03 (a)
GUCY1B1 36
  • 99 (a)
(Canis familiaris)
Mammalia GUCY1B3 35
  • 92.84 (n)
  • 99.52 (a)
GUCY1B3 36
  • 99 (a)
(Mus musculus)
Mammalia Gucy1b3 35
  • 88.69 (n)
  • 98.87 (a)
Gucy1b3 16
Gucy1b3 36
  • 99 (a)
(Pan troglodytes)
Mammalia GUCY1B3 35
  • 99.78 (n)
  • 100 (a)
GUCY1B3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gucy1b3 35
  • 88.42 (n)
  • 98.87 (a)
(Monodelphis domestica)
Mammalia GUCY1B3 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia GUCY1B3 36
  • 97 (a)
(Gallus gallus)
Aves GUCY1B3 35
  • 83.98 (n)
  • 97.56 (a)
GUCY1B3 36
  • 97 (a)
(Anolis carolinensis)
Reptilia GUCY1B3 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy1b3 35
  • 80.53 (n)
  • 94.94 (a)
(Danio rerio)
Actinopterygii gucy1b3 35
  • 77.21 (n)
  • 89.62 (a)
gucy1b3 36
  • 89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14885 37
  • 28 (a)
CG14886 37
  • 37 (a)
CG4154 37
  • 35 (a)
Gycbgr100B 37
  • 58 (a)
Gycbeta100B 35
  • 58.57 (n)
  • 61.65 (a)
Gycbeta100B 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000214 35
  • 57.91 (n)
  • 61.86 (a)
(Caenorhabditis elegans)
Secernentea gcy-31 37
  • 36 (a)
gcy-32 37
  • 33 (a)
gcy-34 37
  • 33 (a)
gcy-35 37
  • 34 (a)
gcy-37 37
  • 29 (a)
gcy-34 35
  • 48.04 (n)
  • 39.1 (a)
acy-3 36
  • 9 (a)
gcy-31 36
  • 27 (a)
gcy-33 36
  • 18 (a)
gcy-37 36
  • 25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13250 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for GUCY1B3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY1B3 Gene

Gene Tree for GUCY1B3 (if available)
Gene Tree for GUCY1B3 (if available)

Paralogs for GUCY1B3 Gene

(7) SIMAP similar genes for GUCY1B3 Gene using alignment to 5 proteins: Pseudogenes for GUCY1B3 Gene

genes like me logo Genes that share paralogs with GUCY1B3: view

Variants for GUCY1B3 Gene

Sequence variations from dbSNP and Humsavar for GUCY1B3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs140330514 -- 155,803,404(+) CTGCC(C/G)GTCAT intron-variant
rs140392048 -- 155,778,355(+) CATTT(C/G)TGAGA intron-variant
rs140264002 -- 155,759,553(+) AGGGT(G/T)GGAAG intron-variant
rs140185870 -- 155,807,593(+) CGTGT(C/T)TCTAT utr-variant-3-prime
rs140129785 -- 155,794,910(+) CAATC(A/C)GTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GUCY1B3 Gene

Variant ID Type Subtype PubMed ID
dgv5787n71 CNV Loss 21882294
nsv818286 CNV Gain 17921354
nsv521382 CNV Loss 19592680

Relevant External Links for GUCY1B3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCY1B3 Gene

Disorders for GUCY1B3 Gene

No disorders were found for GUCY1B3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GUCY1B3 Gene

Publications for GUCY1B3 Gene

  1. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. (PMID: 1352257) Giuili G. … Guellaeen G. (FEBS Lett. 1992) 2 3 4
  2. Heterogeneity in human soluble guanylate cyclase due to alternative splicing. (PMID: 1680753) Chhajilani V. … Wikberg J.E.S. (FEBS Lett. 1991) 3 4
  3. Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction. (PMID: 16528291) Mateos-CA!ceres P.J. … LA^pez-FarrAc A.J. (Int. J. Impot. Res. 2006) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for GUCY1B3 Gene

Sources for GUCY1B3 Gene

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