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Aliases for GUCY1A3 Gene

Aliases for GUCY1A3 Gene

  • Guanylate Cyclase 1, Soluble, Alpha 3 2 3 5
  • Soluble Guanylate Cyclase Large Subunit 3 4
  • GCS-Alpha-3 3 4
  • EC 4.6.1.2 4 63
  • GUCY1A1 3 4
  • GUC1A3 3 4
  • GUCSA3 3 4
  • GC-S-Alpha-1 3
  • GCS-Alpha-1 4
  • GC-SA3 3
  • GUCA3 3
  • MYMY6 3

External Ids for GUCY1A3 Gene

Previous HGNC Symbols for GUCY1A3 Gene

  • GUC1A3

Previous GeneCards Identifiers for GUCY1A3 Gene

  • GC04P157475
  • GC04P157016
  • GC04P157165
  • GC04P156945
  • GC04P156807
  • GC04P156587
  • GC04P152327

Summaries for GUCY1A3 Gene

Entrez Gene Summary for GUCY1A3 Gene

  • Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for GUCY1A3 Gene

GUCY1A3 (Guanylate Cyclase 1, Soluble, Alpha 3) is a Protein Coding gene. Diseases associated with GUCY1A3 include moyamoya 6 with achalasia and myocardial infarction. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include nucleotide binding and receptor activity. An important paralog of this gene is NPR1.

Tocris Summary for GUCY1A3 Gene

  • Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. There are two main groups of guanylyl cyclase.

Gene Wiki entry for GUCY1A3 Gene

No data available for UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY1A3 Gene

Genomics for GUCY1A3 Gene

Regulatory Elements for GUCY1A3 Gene

Promoters for GUCY1A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GUCY1A3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GUCY1A3 gene promoter:

Genomic Location for GUCY1A3 Gene

Chromosome:
4
Start:
155,666,568 bp from pter
End:
155,737,062 bp from pter
Size:
70,495 bases
Orientation:
Plus strand

Genomic View for GUCY1A3 Gene

Genes around GUCY1A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCY1A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCY1A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY1A3 Gene

Proteins for GUCY1A3 Gene

  • Protein details for GUCY1A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02108-GCYA3_HUMAN
    Recommended name:
    Guanylate cyclase soluble subunit alpha-3
    Protein Accession:
    Q02108
    Secondary Accessions:
    • D3DP19
    • D6RDW3
    • O43843
    • Q8TAH3

    Protein attributes for GUCY1A3 Gene

    Size:
    690 amino acids
    Molecular mass:
    77452 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1B3 (PubMed:9742212, PubMed:23505436, PubMed:24669844).
    Miscellaneous:
    • There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.
    SequenceCaution:
    • Sequence=CAA47145.1; Type=Frameshift; Positions=123, 127, 131, 162, 184, 529, 535, 678, 680; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GUCY1A3 Gene

    Alternative splice isoforms for GUCY1A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GUCY1A3 Gene

Proteomics data for GUCY1A3 Gene at MOPED

Post-translational modifications for GUCY1A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GUCY1A3 Gene

Suggested Antigen Peptide Sequences for GUCY1A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02108

UniProtKB/Swiss-Prot:

GCYA3_HUMAN :
  • Contains 1 guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • Contains 1 guanylate cyclase domain.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY1A3: view

Function for GUCY1A3 Gene

Molecular function for GUCY1A3 Gene

GENATLAS Biochemistry:
guanylate cyclase,soluble,alpha-1 subunit,82kDa,heterodimerizing with GUCY1B3, expressed in lung and brain
UniProtKB/Swiss-Prot CatalyticActivity:
GTP = 3,5-cyclic GMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by nitric oxide in the presence of magnesium or manganese ions.

Enzyme Numbers (IUBMB) for GUCY1A3 Gene

Gene Ontology (GO) - Molecular Function for GUCY1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9742212
GO:0005515 protein binding IPI 23505436
genes like me logo Genes that share ontologies with GUCY1A3: view
genes like me logo Genes that share phenotypes with GUCY1A3: view

Human Phenotype Ontology for GUCY1A3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GUCY1A3 Gene

MGI Knock Outs for GUCY1A3:

Animal Model Products

miRNA for GUCY1A3 Gene

miRTarBase miRNAs that target GUCY1A3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for GUCY1A3 Gene

Localization for GUCY1A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY1A3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GUCY1A3 Gene COMPARTMENTS Subcellular localization image for GUCY1A3 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GUCY1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008074 guanylate cyclase complex, soluble IDA 23505436
genes like me logo Genes that share ontologies with GUCY1A3: view

Pathways & Interactions for GUCY1A3 Gene

genes like me logo Genes that share pathways with GUCY1A3: view

Gene Ontology (GO) - Biological Process for GUCY1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0008217 regulation of blood pressure IEA --
GO:0009190 cyclic nucleotide biosynthetic process IEA --
GO:0009635 response to herbicide IEA --
GO:0030828 positive regulation of cGMP biosynthetic process IEA --
genes like me logo Genes that share ontologies with GUCY1A3: view

No data available for SIGNOR curated interactions for GUCY1A3 Gene

Drugs & Compounds for GUCY1A3 Gene

(6) Drugs for GUCY1A3 Gene - From: HMDB and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclic GMP Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
RIOCIGUAT Pharma 0
Manganese Pharma 32

(6) Additional Compounds for GUCY1A3 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
A 350619 hydrochloride
1217201-17-6
CFM 1571 hydrochloride
1215548-30-3
Guanylin (human)
183200-12-6
SIN-1 chloride
16142-27-1
genes like me logo Genes that share compounds with GUCY1A3: view

Transcripts for GUCY1A3 Gene

Unigene Clusters for GUCY1A3 Gene

Guanylate cyclase 1, soluble, alpha 3:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1A3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - - -
SP17: - - - -
SP18: - - - - - -
SP19:
SP20:
SP21: - - - - - - - - -

ExUns: 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - -
SP7: - - - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20: -
SP21:

Relevant External Links for GUCY1A3 Gene

GeneLoc Exon Structure for
GUCY1A3
ECgene alternative splicing isoforms for
GUCY1A3

Expression for GUCY1A3 Gene

mRNA expression in normal human tissues for GUCY1A3 Gene

Protein differential expression in normal tissues from HIPED for GUCY1A3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.1) and Platelet (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GUCY1A3 Gene



SOURCE GeneReport for Unigene cluster for GUCY1A3 Gene Hs.24258

mRNA Expression by UniProt/SwissProt for GUCY1A3 Gene

Q02108-GCYA3_HUMAN
Tissue specificity: Detected in brain cortex and lung (at protein level).
genes like me logo Genes that share expression patterns with GUCY1A3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for GUCY1A3 Gene

Orthologs for GUCY1A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY1A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GUCY1A3 36
  • 100 (a)
OneToOne
GUCY1A3 35
  • 99.66 (n)
  • 99.71 (a)
cow
(Bos Taurus)
Mammalia GUCY1A1 36
  • 86 (a)
OneToOne
GUCY1A3 35
  • 83.19 (n)
  • 86.23 (a)
dog
(Canis familiaris)
Mammalia GUCY1A3 35
  • 89.61 (n)
  • 93.48 (a)
GUCY1A3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gucy1a3 16
Gucy1a3 35
  • 84.2 (n)
  • 89.86 (a)
Gucy1a3 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GUCY1A3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GUCY1A3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gucy1a3 35
  • 84.18 (n)
  • 89.26 (a)
chicken
(Gallus gallus)
Aves GUCY1A3 35
  • 78.29 (n)
  • 84.16 (a)
GUCY1A3 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GUCY1A3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy1a3 35
  • 72.93 (n)
  • 74.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6530 35
zebrafish
(Danio rerio)
Actinopterygii gucy1a3 36
  • 59 (a)
OneToOne
Dr.12554 35
gucy1a3 35
  • 54.78 (n)
  • 53.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gycalpha99B 36
  • 35 (a)
OneToMany
Gycalpha99B 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea gcy-29 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for GUCY1A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY1A3 Gene

ENSEMBL:
Gene Tree for GUCY1A3 (if available)
TreeFam:
Gene Tree for GUCY1A3 (if available)

Paralogs for GUCY1A3 Gene

Paralogs for GUCY1A3 Gene

(7) SIMAP similar genes for GUCY1A3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GUCY1A3: view

Variants for GUCY1A3 Gene

Sequence variations from dbSNP and Humsavar for GUCY1A3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2170646 - 155,696,940(-) AGGAA(C/T)TTGAC reference, missense, utr-variant-5-prime
rs719814 -- 155,681,686(+) GTCAT(A/T)ATACT intron-variant
rs1994137 -- 155,674,808(-) agagg(A/G)tacta intron-variant
rs2062174 -- 155,677,177(-) ACTCA(C/T)TCATT intron-variant
rs1962695 -- 155,688,244(-) ttttt(G/T)tttgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GUCY1A3 Gene

Variant ID Type Subtype PubMed ID
nsv437445 CNV Loss 16327808
esv2674234 CNV Deletion 23128226
esv23465 CNV Loss 19812545
nsv442925 CNV CNV 18776908
esv2421932 CNV Deletion 20811451
nsv514260 CNV Loss 21397061
esv2514554 CNV Deletion 19546169
nsv519870 CNV Loss 19592680
nsv509940 CNV Loss 20534489
dgv1699e1 CNV Complex 17122850
esv275314 CNV Loss 21479260
nsv4563 CNV Insertion 18451855

Variation tolerance for GUCY1A3 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUCY1A3 Gene

HapMap Linkage Disequilibrium report
GUCY1A3
Human Gene Mutation Database (HGMD)
GUCY1A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCY1A3 Gene

Disorders for GUCY1A3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for GUCY1A3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
moyamoya 6 with achalasia
  • moyamoya disease 6 with achalasia
myocardial infarction
  • myocardial infarction, protection against
moyamoya disease with early-onset achalasia
achalasia
  • achalasia of cardia
moyamoya disease
  • progressive intracranial arterial occlusion
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GCYA3_HUMAN
  • Moyamoya disease 6 with achalasia (MYMY6) [MIM:615750]: A form of Moyamoya disease, a progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a puff of smoke (moyamoya) on cerebral angiogram. Affected individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults. MYMY6 is characterized by severe cerebral angiopathy and onset of severe achalasia in infancy or early childhood. {ECO:0000269 PubMed:24581742}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GUCY1A3

Genetic Association Database (GAD)
GUCY1A3
Human Genome Epidemiology (HuGE) Navigator
GUCY1A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GUCY1A3
genes like me logo Genes that share disorders with GUCY1A3: view

No data available for Genatlas for GUCY1A3 Gene

Publications for GUCY1A3 Gene

  1. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. (PMID: 1352257) Giuili G. … Guellaeen G. (FEBS Lett. 1992) 2 3 4 67
  2. Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3. (PMID: 15201957) Saino M. … Murakami Y. (Oncol. Rep. 2004) 3 23
  3. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. (PMID: 25249183) Lu X. … Gu D. (Hum. Mol. Genet. 2015) 3
  4. COP9 subunits 4 and 5 target soluble guanylyl cyclase I+1 and p53 in prostate cancer cells. (PMID: 24725084) Bhansali M. … Shemshedini L. (Mol. Endocrinol. 2014) 3
  5. HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways. (PMID: 24666322) Krogh K.A. … Thayer S.A. (J. Neurochem. 2014) 3

Products for GUCY1A3 Gene

Sources for GUCY1A3 Gene

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