Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GUCY1A3 Gene

Aliases for GUCY1A3 Gene

  • Guanylate Cyclase 1, Soluble, Alpha 3 2 3
  • GUC1A3 3 4 6
  • GUCSA3 3 4 6
  • Soluble Guanylate Cyclase Large Subunit 3 4
  • GCS-Alpha-3 3 4
  • EC 4.6.1.2 4 63
  • GUCY1A1 3 4
  • Guanylate Cyclase Soluble Subunit Alpha-3 3
  • GC-S-Alpha-1 3
  • GCS-Alpha-1 4
  • GC-SA3 3
  • GUCA3 3
  • MYMY6 3

External Ids for GUCY1A3 Gene

Previous HGNC Symbols for GUCY1A3 Gene

  • GUC1A3

Previous GeneCards Identifiers for GUCY1A3 Gene

  • GC04P157475
  • GC04P157016
  • GC04P157165
  • GC04P156945
  • GC04P156807
  • GC04P156587
  • GC04P152327

Summaries for GUCY1A3 Gene

Entrez Gene Summary for GUCY1A3 Gene

  • Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for GUCY1A3 Gene

GUCY1A3 (Guanylate Cyclase 1, Soluble, Alpha 3) is a Protein Coding gene. Diseases associated with GUCY1A3 include moyamoya 6 with achalasia and moyamoya disease with early-onset achalasia. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include GTP binding and heme binding. An important paralog of this gene is ADCY5.

Tocris Summary for GUCY1A3 Gene

  • Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases. There are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.

Gene Wiki entry for GUCY1A3 Gene

No data available for UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY1A3 Gene

Genomics for GUCY1A3 Gene

Regulatory Elements for GUCY1A3 Gene

Transcription factor binding sites by QIAGEN in the GUCY1A3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GUCY1A3 Gene

Start:
155,666,710 bp from pter
End:
155,737,062 bp from pter
Size:
70,353 bases
Orientation:
Plus strand

Genomic View for GUCY1A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GUCY1A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY1A3 Gene

Proteins for GUCY1A3 Gene

  • Protein details for GUCY1A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02108-GCYA3_HUMAN
    Recommended name:
    Guanylate cyclase soluble subunit alpha-3
    Protein Accession:
    Q02108
    Secondary Accessions:
    • D3DP19
    • D6RDW3
    • O43843
    • Q8TAH3

    Protein attributes for GUCY1A3 Gene

    Size:
    690 amino acids
    Molecular mass:
    77452 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta chain
    Miscellaneous:
    • There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms
    SequenceCaution:
    • Sequence=CAA47145.1; Type=Frameshift; Positions=123, 127, 131, 162, 184, 529, 535, 678, 680; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GUCY1A3 Gene

    Alternative splice isoforms for GUCY1A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GUCY1A3 Gene

Proteomics data for GUCY1A3 Gene at MOPED

Post-translational modifications for GUCY1A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for GUCY1A3 Gene

Gene Families for GUCY1A3 Gene

Suggested Antigen Peptide Sequences for GUCY1A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02108

UniProtKB/Swiss-Prot:

GCYA3_HUMAN :
  • Q02108
Domain:
  • Contains 1 guanylate cyclase domain.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY1A3: view

Function for GUCY1A3 Gene

Molecular function for GUCY1A3 Gene

GENATLAS Biochemistry: guanylate cyclase,soluble,alpha-1 subunit,82kDa,heterodimerizing with GUCY1B3, expressed in lung and brain
UniProtKB/Swiss-Prot CatalyticActivity: GTP = 3,5-cyclic GMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by nitric oxide in the presence of magnesium or manganese ions

Enzyme Numbers (IUBMB) for GUCY1A3 Gene

Gene Ontology (GO) - Molecular Function for GUCY1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004383 guanylate cyclase activity IEA --
GO:0004872 receptor activity TAS 9742212
GO:0005525 GTP binding IEA --
GO:0016849 phosphorus-oxygen lyase activity --
genes like me logo Genes that share ontologies with GUCY1A3: view
genes like me logo Genes that share phenotypes with GUCY1A3: view

Animal Models for GUCY1A3 Gene

MGI Knock Outs for GUCY1A3:

Animal Model Products

CRISPR Products

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for GUCY1A3 Gene

Localization for GUCY1A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY1A3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GUCY1A3 Gene COMPARTMENTS Subcellular localization image for GUCY1A3 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GUCY1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008074 guanylate cyclase complex, soluble TAS 1352257
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GUCY1A3: view

Pathways for GUCY1A3 Gene

genes like me logo Genes that share pathways with GUCY1A3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for GUCY1A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IEA --
GO:0007263 nitric oxide mediated signal transduction TAS 9742212
GO:0007596 blood coagulation TAS --
GO:0008015 blood circulation TAS 9742212
GO:0008217 regulation of blood pressure IEA --
genes like me logo Genes that share ontologies with GUCY1A3: view

Compounds for GUCY1A3 Gene

(5) Tocris Compounds for GUCY1A3 Gene

Compound Action Cas Number
A 350619 hydrochloride Soluble guanylyl cyclase (sGC) activator [1217201-17-6]
BAY 41-2272 Soluble guanylyl cyclase (sGC) activator [256376-24-6]
NS 2028 Potent soluble guanylyl cyclase (sGC) inhibitor [204326-43-2]
YC 1 Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest [170632-47-0]
Zinc protoporphyrin IX Heme oxygenase and guanylyl cyclase inhibitor [15442-64-5]

(6) HMDB Compounds for GUCY1A3 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine triphosphate
  • 5'-GTP
86-01-1
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
genes like me logo Genes that share compounds with GUCY1A3: view

Transcripts for GUCY1A3 Gene

Unigene Clusters for GUCY1A3 Gene

Guanylate cyclase 1, soluble, alpha 3:
Representative Sequences:

CRISPR Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1A3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - - -
SP17: - - - -
SP18: - - - - - -
SP19:
SP20:
SP21: - - - - - - - - -

ExUns: 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - -
SP7: - - - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20: -
SP21:

Relevant External Links for GUCY1A3 Gene

GeneLoc Exon Structure for
GUCY1A3
ECgene alternative splicing isoforms for
GUCY1A3

Expression for GUCY1A3 Gene

mRNA expression in normal human tissues for GUCY1A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GUCY1A3 Gene

SOURCE GeneReport for Unigene cluster for GUCY1A3 Gene Hs.24258

genes like me logo Genes that share expressions with GUCY1A3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GUCY1A3 Gene

Orthologs for GUCY1A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY1A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GUCY1A3 35
  • 99.66 (n)
  • 99.71 (a)
GUCY1A3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GUCY1A1 36
  • 86 (a)
OneToOne
GUCY1A3 35
  • 83.19 (n)
  • 86.23 (a)
dog
(Canis familiaris)
Mammalia GUCY1A3 35
  • 89.61 (n)
  • 93.48 (a)
GUCY1A3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gucy1a3 35
  • 84.2 (n)
  • 89.86 (a)
Gucy1a3 16
Gucy1a3 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GUCY1A3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GUCY1A3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gucy1a3 35
  • 84.18 (n)
  • 89.26 (a)
chicken
(Gallus gallus)
Aves GUCY1A3 35
  • 78.29 (n)
  • 84.16 (a)
GUCY1A3 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GUCY1A3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy1a3 35
  • 72.93 (n)
  • 74.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6530 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12554 35
gucy1a3 35
  • 54.78 (n)
  • 53.7 (a)
gucy1a3 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Gycalpha99B 36
  • 35 (a)
OneToMany
Gycalpha99B 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea gcy-29 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for GUCY1A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY1A3 Gene

ENSEMBL:
Gene Tree for GUCY1A3 (if available)
TreeFam:
Gene Tree for GUCY1A3 (if available)

Paralogs for GUCY1A3 Gene

Selected SIMAP similar genes for GUCY1A3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GUCY1A3: view

Variants for GUCY1A3 Gene

Sequence variations from dbSNP and Humsavar for GUCY1A3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3500 -- 155,736,981(-) TCTGA(A/G)ACAGG utr-variant-3-prime
rs14577 -- 155,733,559(-) TCATG(C/T)AAAGC utr-variant-3-prime
rs719814 -- 155,681,686(+) GTCAT(A/T)ATACT intron-variant
rs1017858 -- 155,688,309(-) acaca(C/T)acata intron-variant
rs1049509 -- 155,711,167(+) CAGAC(C/G)TTTAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for GUCY1A3 Gene

Variant ID Type Subtype PubMed ID
nsv437445 CNV Loss 16327808
esv2674234 CNV Deletion 23128226
esv23465 CNV Loss 19812545
nsv442925 CNV CNV 18776908
esv2421932 CNV Deletion 20811451
nsv514260 CNV Loss 21397061
esv2514554 CNV Deletion 19546169
nsv519870 CNV Loss 19592680
nsv509940 CNV Loss 20534489
dgv1699e1 CNV Complex 17122850
esv275314 CNV Loss 21479260
nsv4563 CNV Insertion 18451855

Relevant External Links for GUCY1A3 Gene

HapMap Linkage Disequilibrium report
GUCY1A3
Human Gene Mutation Database (HGMD)
GUCY1A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCY1A3 Gene

Disorders for GUCY1A3 Gene

Relevant External Links for GUCY1A3

Genetic Association Database (GAD)
GUCY1A3
Human Genome Epidemiology (HuGE) Navigator
GUCY1A3
genes like me logo Genes that share disorders with GUCY1A3: view

No data available for UniProtKB/Swiss-Prot for GUCY1A3 Gene

Publications for GUCY1A3 Gene

  1. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. (PMID: 1352257) Giuili G. … Guellaeen G. (FEBS Lett. 1992) 2 3 4
  2. Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3. (PMID: 15201957) Saino M. … Murakami Y. (Oncol. Rep. 2004) 3 23
  3. Human soluble guanylate cyclase: functional expression and revised isoenzyme family. (PMID: 9742212) Zabel U. … Schmidt H.H. (Biochem. J. 1998) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3 48

Products for GUCY1A3 Gene

Sources for GUCY1A3 Gene

Back to Top

Content