Aliases for GUCY1A3 Gene
External Ids for GUCY1A3 Gene
Previous HGNC Symbols for GUCY1A3 Gene
Previous GeneCards Identifiers for GUCY1A3 Gene
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for GUCY1A3 Gene
GUCY1A3 (Guanylate Cyclase 1, Soluble, Alpha 3) is a Protein Coding gene. Diseases associated with GUCY1A3 include moyamoya 6 with achalasia and myocardial infarction. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include nucleotide binding and receptor activity. An important paralog of this gene is NPR1.
Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. There are two main groups of guanylyl cyclase.