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GUCY1A3 Gene

protein-coding   GIFtS: 64
GCID: GC04P156587

Guanylate Cyclase 1, Soluble, Alpha 3


(Previous symbol: GUC1A3)
  See GUCY1A3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanylate Cyclase 1, Soluble, Alpha 31 2     GUCY1A12 3
GUC1A31 2 3 5     EC 4.6.1.23 8
GUCSA32 3 5     GC-S-alpha-12
Soluble Guanylate Cyclase Large Subunit2 3     GC-SA32
GCS-alpha-12 3     GUCA32
GCS-alpha-32 3     Guanylate Cyclase Soluble Subunit Alpha-32

External Ids:    HGNC: 46851   Entrez Gene: 29822   Ensembl: ENSG000001641167   OMIM: 1393965   UniProtKB: Q021083   

Export aliases for GUCY1A3 gene to outside databases

Previous GC identifers: GC04P157475 GC04P157016 GC04P157165 GC04P156945 GC04P156807 GC04P152327


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GUCY1A3 Gene:
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and
pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta
subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants
encoding a few different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for GUCY1A3 Gene:
GUCY1A3 (guanylate cyclase 1, soluble, alpha 3) is a protein-coding gene. Diseases associated with GUCY1A3 include moyamoya 6 with achalasia. GO annotations related to this gene include GTP binding and heme binding. An important paralog of this gene is ADCY5.

summary for GUCY1A3 Gene:
Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or
Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate.
The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the
conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases. There
are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and
transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for
guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix
production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important
communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.

Gene Wiki entry for GUCY1A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GUCY1A3 gene promoter:
         Pax-2   Pax-2a   TGIF   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGUCY1A3 promoter sequence
   Search Chromatin IP Primers for GUCY1A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GUCY1A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.1-q31.2   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31.3-q33

GUCY1A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GUCY1A3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P156587:  view genomic region     (about GC identifiers)

Start:
156,587,862 bp from pter      End:
156,658,214 bp from pter
Size:
70,353 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GCYA3_HUMAN, Q02108 (See protein sequence)
Recommended Name: Guanylate cyclase soluble subunit alpha-3  
Size: 690 amino acids; 77452 Da
Subunit: Heterodimer of an alpha and a beta chain
Miscellaneous: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms
Sequence caution: Sequence=CAA47145.1; Type=Frameshift; Positions=123, 127, 131, 162, 184, 529, 535, 678, 680;
1 PDB 3D structure from and Proteopedia for GUCY1A3:
3UVJ (3D)    
Secondary accessions: D3DP19 D6RDW3 O43843 Q8TAH3
Alternative splicing: 2 isoforms:  Q02108-1   Q02108-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GUCY1A3: NX_Q02108

Explore proteomics data for GUCY1A3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GUCY1A3 (Q02108) (see all 22)
     VAQQLWQ  LSDIPIH  RIGLHSG  LKGQMIY 


    See GUCY1A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_000847.2  NP_001124154.1  NP_001124155.1  NP_001124156.1  NP_001124157.1  NP_001124159.1  NP_001243378.1  

    ENSEMBL proteins: 
     ENSP00000424361   ENSP00000421493   ENSP00000426968   ENSP00000412201   ENSP00000424863  
     ENSP00000409903   ENSP00000377418   ENSP00000296518   ENSP00000422141   ENSP00000426040  
    Reactome Protein details: Q02108

    GUCY1A3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GUCY1A3 

     
    antibodies-online proteins for GUCY1A3 (7 products) 

     
    antibodies-online peptides for GUCY1A3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Soluble guanylyl cyclase alpha 1 subunit
    Soluble guanylyl cyclase

    5 InterPro protein domains:
     IPR011644 Heme_NO-bd
     IPR024096 NO_sig/Golgi_transp_ligand-bd
     IPR011645 Haem_no_assoc-bd
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry Q02108

    ProtoNet protein and cluster: Q02108

    UniProtKB/Swiss-Prot: GCYA3_HUMAN, Q02108
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 1 guanylate cyclase domain


    Find genes that share domains with GUCY1A3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCYA3_HUMAN, Q02108
    Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate
    Enzyme regulation: Activated by nitric oxide in the presence of magnesium or manganese ions

         Genatlas biochemistry entry for GUCY1A3:
    guanylate cyclase,soluble,alpha-1 subunit,82kDa,heterodimerizing with GUCY1B3, expressed in lung and brain

         Enzyme Number (IUBMB): EC 4.6.1.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004383guanylate cyclase activity IEA--
    GO:0004872receptor activity TAS9742212
    GO:0005525GTP binding IEA--
    GO:0016849phosphorus-oxygen lyase activity ----
         
    Find genes that share ontologies with GUCY1A3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GUCY1A3:
     Decreased POU5F1-GFP protein e  Increased G1 DNA content 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gucy1a3):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  mortality/aging  muscle 
     nervous system  no phenotypic analysis  respiratory system  vision/eye 

    Find genes that share phenotypes with GUCY1A3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GUCY1A3: Gucy1a3tm1.1Dko Gucy1a3tm1.1Brou

       genOway: Develop your customized and physiologically relevant rodent model for GUCY1A3

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    Selected qRT-PCR Assays for microRNAs that regulate GUCY1A3 (see all 27):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-429 hsa-miR-106a hsa-miR-302e hsa-miR-374c hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidGUCY1A3 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for GUCY1A3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GUCY1A3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GCYA3_HUMAN, Q02108: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008074guanylate cyclase complex, soluble TAS1352257
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with GUCY1A3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GUCY1A3 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    2G-Beta Gamma Signaling
    CRHR Pathway0.44
    Relaxin Pathway0.37
    3Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    4Oxytocin signaling pathway
    Oxytocin signaling pathway0.32
    Vascular smooth muscle contraction0.32
    5Development Angiotensin activation of ERK
    Development EDNRB signaling0.54


    Find genes that share SuperPaths with GUCY1A3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GUCY1A3 (see all 10)
        Sertoli-Sertoli Cell Junction Dynamics
    Relaxin Pathway
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CRHR Pathway

    2 GeneGo (Thomson Reuters) Pathways for GUCY1A3
        Development EDNRB signaling
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

    1 BioSystems Pathway for GUCY1A3
        Myometrial Relaxation and Contraction Pathways

    1 Reactome Pathway for GUCY1A3
        Nitric oxide stimulates guanylate cyclase


    Selected Kegg Pathways  (Kegg details for GUCY1A3) (see all 7):
        Purine metabolism
    Vascular smooth muscle contraction
    Gap junction
    Circadian entrainment
    Long-term depression

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GUCY1A3: 
              Hypertension in human mouse rat
              Neurotoxicity in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GUCY1A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GUCY1A3 (Q021083 ENSP000002965184) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STUB1Q9UNE73, ENSP000002195484I2D: score=2 STRING: ENSP00000219548
    AGAP1Q9UPQ33, ENSP000003076344I2D: score=1 STRING: ENSP00000307634
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ENTPD1ENSP000003602484STRING: ENSP00000360248
    ENTPD3ENSP000003018254STRING: ENSP00000301825
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006182cGMP biosynthetic process ----
    GO:0007263nitric oxide mediated signal transduction TAS9742212
    GO:0007596blood coagulation TAS--
    GO:0008015blood circulation TAS9742212
    GO:0008217regulation of blood pressure IEA--

    Find genes that share ontologies with GUCY1A3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for GUCY1A3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    A 350619 hydrochlorideSoluble guanylyl cyclase (sGC) activator[538368-27-3]
    Zinc protoporphyrin IXHeme oxygenase and guanylyl cyclase inhibitor[15442-64-5]
    NS 2028Potent soluble guanylyl cyclase (sGC) inhibitor[204326-43-2]
    YC 1Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest[170632-47-0]
    BAY 41-2272Soluble guanylyl cyclase (sGC) activator[256376-24-6]

    6 HMDB Compounds for GUCY1A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GUCY1A3 gene (8 alternative transcripts): 
    NM_000856.5  NM_001130682.2  NM_001130683.3  NM_001130684.2  NM_001130685.2  NM_001130687.2  NM_001256449.1  NM_001130686.1  

    Unigene Cluster for GUCY1A3:

    Guanylate cyclase 1, soluble, alpha 3
    Hs.24258  [show with all ESTs]
    Unigene Representative Sequence: NM_000856
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506455(uc010iqc.2) ENST00000511108 ENST00000512983(uc003iou.2)
    ENST00000511507 ENST00000515602 ENST00000455639 ENST00000509901 ENST00000443668(uc010iqe.3)
    ENST00000393832(uc003ioz.3) ENST00000296518(uc003iov.3 uc010iqd.3 uc003iow.3 uc003iox.3 uc003ioy.3 uc003ipa.3 uc003ipb.3)
    ENST00000515201 ENST00000513574
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    Additional mRNA sequence: 

    AK096588.1 AK124244.1 AK226125.1 AK309950.1 AK312952.1 BC012627.1 BC028384.2 BC039414.1 
    BC095395.1 BX647200.1 BX649180.1 U58855.1 Y15723.1 

    22 DOTS entries:

    DT.65288202  DT.95310327  DT.99990610  DT.114012  DT.75114798  DT.101955542  DT.435042  DT.100783539 
    DT.102825253  DT.100774620  DT.100783540  DT.97841391  DT.100783538  DT.102825252  DT.91718860  DT.95354200 
    DT.121274981  DT.91745116  DT.91835978  DT.95248994  DT.121274943  DT.95101981 

    Selected AceView cDNA sequences (see all 148):

    AW613972 CN481324 BI493573 BC012627 BX642784 CA390437 CA388942 AL707876 
    BP373039 BX280045 CR614534 BI769310 CB156626 CR618242 T17164 BM710102 
    BX336790 AI769921 CN485190 AW117228 AW664672 BX505476 BX647200 BI551700 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1A3 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^
    SP1:                                      -     -     -     -     -     -     -     -           -           -     -     -                                       
    SP2:                                      -     -     -     -     -     -     -     -           -           -     -     -                                       
    SP3:                                      -     -     -     -     -     -     -     -           -     -     -     -     -                                       
    SP4:                                                                    -     -     -           -     -     -     -     -     -                                 
    SP5:                                                                          -     -           -     -     -     -     -                                       

    ExUns: 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                                        -                 -               
    SP2:              -                                         -                 -               
    SP3:                                                        -                 -               
    SP4:                                                        -                 -               
    SP5:                    -     -                             -                 -               


    ECgene alternative splicing isoforms for GUCY1A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GUCY1A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAAATGTA
    GUCY1A3 Expression
    About this image


    GUCY1A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Endochondral Facial Bones
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    GUCY1A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GUCY1A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24258
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GUCY1A3: 
              Hypertension in human mouse rat
              Neurotoxicity in human mouse rat
              Gap Junctions in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GUCY1A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GUCY1A3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gucy1a31 , 5 guanylate cyclase 1, soluble, alpha 31, 5 84.2(n)1
    89.86(a)1
      3 (35.97 cM)5
    605961  NM_021896.51  NP_068696.21 
     820924285 
    chicken
    (Gallus gallus)
    Aves GUCY1A31 guanylate cyclase 1, soluble, alpha 3 78.29(n)
    84.16(a)
      422407  XM_420375.4  XP_420375.1 
    lizard
    (Anolis carolinensis)
    Reptilia GUCY1A36
    guanylate cyclase 1, soluble, alpha 3
    83(a)
    1 ↔ 1
    5(129593486-129640532)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gucy1a31 guanylate cyclase 1, soluble, alpha 3 72.93(n)
    74.66(a)
      100496677  XM_004911155.1  XP_004911212.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125542 Transcribed sequence with weak similarity to protein more 76.56(n)    BI845097.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gycalpha99B3 optokinetic behavior guanylate cyclase 34(a)   3 99B7   --
    worm
    (Caenorhabditis elegans)
    Secernentea gcy-296
    Protein GCY-29 (gcy-29) mRNA, complete cds
    13(a)
    many ↔ many
    II(14540819-14548791) WBGene00007314


    ENSEMBL Gene Tree for GUCY1A3 (if available)
    TreeFam Gene Tree for GUCY1A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GUCY1A3 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  
    ADCY72  ADCY92  GUCY1B32  ADCY62  ADCY12  ADCY42  NPR22  ADCY32  
    7 SIMAP similar genes for GUCY1A3 using alignment to 5 protein entries:     GCYA3_HUMAN (see all proteins):
    GUCY1A2    NPR2    ADCY5    GUCY1B2    NPR1    GUCY1B3
    ADCY3

    Find genes that share paralogs with GUCY1A3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GUCY1A3 (see all 1536)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38067751,2
    C--152325452(+) ACTGAG/ATAATT 3 -- int14Minor allele frequency- A:0.14WA NA EA 360
    rs1864786421,2
    --152325541(+) CATAAA/GTCAAC 2 -- int10--------
    rs1435059751,2
    --152325551(+) CTATAA/GGAAAG 2 -- int10--------
    rs794363541,2
    C,F--152326060(+) AGCAAC/AAACAA 1 -- us2k13Minor allele frequency- A:0.09WA NA EA 358
    rs38067761,2
    C,F,H--152326213(+) CAGTGT/CCATGC 1 -- us2k119Minor allele frequency- C:0.12EA NS NA WA 3656
    rs1410802401,2
    --156585875(+) TGCCAC/TTGTCC 3 -- us2k10--------
    rs594415471,2
    C--156585921(+) ATGCTT/CTCATG 3 -- us2k14Minor allele frequency- C:0.14WA NA EA 360
    rs1166585711,2
    F--156585929(+) ATGCTG/CTTGTC 3 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1913588521,2
    --156586220(+) AATCCC/TGTTAT 6 -- us2k10--------
    rs1810167521,2
    --156586275(+) TTCCCC/TAACAA 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for GUCY1A3 (156587862 - 156658214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GUCY1A3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2514554CNV Deletion19546169
    esv2674234CNV Deletion23128226
    esv2421932CNV Deletion20811451
    nsv4563CNV Insertion18451855
    esv23465CNV Loss19812545
    nsv437445CNV Loss16327808
    esv275314CNV Loss21479260
    nsv514260CNV Loss21397061
    nsv519870CNV Loss19592680
    nsv509940CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GUCY1A3
    DNA2.0 Custom Variant and Variant Library Synthesis for GUCY1A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139396    OMIM disorders: --

    1 disease for GUCY1A3:    
    About MalaCards
    moyamoya 6 with achalasia


    Find genes that share disorders with GUCY1A3           About GenesLikeMe

    Genetic Association Database (GAD): GUCY1A3
    Human Genome Epidemiology (HuGE) Navigator: GUCY1A3 (1 document)

    Export disorders for GUCY1A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GUCY1A3 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with GUCY1A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. (PubMed id 1352257)1, 2, 3 Giuili G.... Guellaeen G. (FEBS Lett. 1992)
    2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    3. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PubMed id 21909115)1, 4  ....Johnson T. (Nature 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Human soluble guanylate cyclase: functional expression and revised isoenzyme family. (PubMed id 9742212)1, 2 Zabel U.... Schmidt H.H. (Biochem. J. 1998)
    7. Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3. (PubMed id 15201957)1, 9 Saino M....Murakami Y. (Oncol. Rep. 2004)
    8. Quaternary structure controls ligand dynamics in soluble guanylate cyclase. (PubMed id 22223482)1 Yoo B.K....Negrerie M. (J. Biol. Chem. 2012)
    9. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase. (PubMed id 22690686)1 Chauhan S....Martin E. (Biochem. J. 2012)
    10. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. (PubMed id 22751097)1 Lu X....Gu D. (Nat. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2982 HGNC: 4685 AceView: GUCY1A3 Ensembl:ENSG00000164116 euGenes: HUgn2982
    ECgene: GUCY1A3 Kegg: 2982 H-InvDB: GUCY1A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GUCY1A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GUCY1A3 gene:
    Search GeneIP for patents involving GUCY1A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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