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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GUCY1A2 Gene

protein-coding   GIFtS: 63
GCID: GC11M106591

guanylate cyclase 1, soluble, alpha 2


(Previous symbol: GUC1A2)
 Explore 3 diseases affiliated with
GUCY1A2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GUCY1A2    

Aliases
for GUCY1A2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Guanylate Cyclase 1, Soluble, Alpha 21 2     EC 4.6.1.23 8
GUC1A21 2 3 5     Guanylate Cyclase Soluble Subunit Alpha-22
GC-SA21 2     GUCSA23
GCS-Alpha-21     

External Ids:    HGNC: 46841   Entrez Gene: 29772   Ensembl: ENSG000001524027   OMIM: 6012445   UniProtKB: P334023   

Export aliases for GUCY1A2 gene to outside databases

Previous GC identifers: GC11M108716 GC11M107914 GC11M106095 GC11M106063 GC11M102490


Summaries
for GUCY1A2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GUCY1A2:
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and
pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta
subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: GCYA2_HUMAN, P33402
Function: Has guanylyl cyclase on binding to the beta-1 subunit
Function: Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers
with the beta subunits

summary for GUCY1A2:
Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or
Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate.
The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the
conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases. There
are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and
transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for
guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix
production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important
communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.

Gene Wiki entry for GUCY1A2


Genomic Views
for GUCY1A2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GUCY1A2 gene promoter:
         Ik-3   Evi-1   CREB   IRF-2   Nkx6-1   POU2F1   FOXJ2 (long isoform)   POU2F1a   Cart-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GUCY1A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GUCY1A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GUCY1A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21-q22   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q21-q22

GUCY1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GUCY1A2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M106591:  view genomic region     (about GC identifiers)

Start:
 106,555,148 bp from pter      End:
 106,889,250 bp from pter
Size:
 334,103 bases      Orientation:
 minus strand

Proteins
for GUCY1A2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GCYA2_HUMAN, P33402 (See protein sequence)
Recommended Name: Guanylate cyclase soluble subunit alpha-2  
Size: 732 amino acids; 81750 Da
Subunit: Heterodimer of an alpha and a beta chain
Subcellular location: Cytoplasm
Miscellaneous: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms
Secondary accessions: A1L4C4
Alternative splicing: 2 isoforms:  P33402-1   P33402-2   

Explore the universe of human proteins at neXtProt for GUCY1A2: NX_P33402

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P33402

    • 4/10 DME Specific Peptides for GUCY1A2 (P33402) (see all 10)
     VAQQLWQ  LSDIPIH  FSDIVGFT  AQDGLKKR 

    GUCY1A2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000846.1  NP_001243353.1  

    ENSEMBL proteins: 
     ENSP00000431245   ENSP00000282249   ENSP00000344874  
    Reactome Protein details: P33402
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005829cytosol ----


    GUCY1A2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for GUCY1A2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GUCY1A2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011644 Heme_NO-bd
     IPR024096 NO_sig/Golgi_transp_ligand-bd
     IPR011645 Haem_no_assoc-bd
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry P33402

    ProtoNet protein and cluster: P33402

    UniProtKB/Swiss-Prot: GCYA2_HUMAN, P33402
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 1 guanylate cyclase domain


    Function
    for GUCY1A2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GCYA2_HUMAN, P33402
    Function: Has guanylyl cyclase on binding to the beta-1 subunit
    Function: Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers
    with the beta subunits
    Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate
    Enzyme regulation: Activated by nitric oxide in the presence of magnesium or manganese ions

         Genatlas biochemistry entry for GUCY1A2:
    guanylate cyclase,soluble,alpha-2 subunit,79kDa,heterodimerizing with GUCY1B1

    Enzyme Number (IUBMB): EC 4.6.1.21 2

    miRNA
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    hsa-miR-3140-3p hsa-miR-137 hsa-miR-1285 hsa-miR-218 hsa-miR-373* hsa-miR-4294 hsa-miR-4314 hsa-miR-612
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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004383guanylate cyclase activity IEA--
    GO:0005525GTP binding IEA--
    GO:0020037heme binding IEA--


    GUCY1A2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for GUCY1A2:
     Decreased cilium length after   Increased cell death in HCC-19  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Gucy1a2tm1.1Dko for GUCY1A2
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gucy1a2):
     cardiovascular system  hematopoietic system  no phenotypic analysis 

    GUCY1A2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GUCY1A2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nitric oxide stimulates guanylate cyclase
    		Nitric oxide stimulates guanylate cyclase1.00
    		Platelet homeostasis0.34
    2Signaling in Gap Junctions
    		Signaling in Gap Junctions1.00
    		Gap junction0.31
    3Development Angiotensin activation of ERK
    		Development EDNRB signaling0.54
    		Development_EDNRB signaling0.54
    4G-Beta Gamma Signaling
    		CRHR Pathway0.44
    		Relaxin Pathway0.32
    5Sweet Taste Signaling
    		Cellular Effects of Sildenafil0.46
    		Sperm Motility0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for GUCY1A2
        Development EDNRB signaling
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GUCY1A2 (see all 10)
        Sertoli-Sertoli Cell Junction Dynamics
    Relaxin Pathway
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CRHR Pathway

    3 GeneGo (Thomson Reuters) Pathways for GUCY1A2
        Development EDNRB signaling
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
    NO-dependent CFTR activation (normal and CF)

    3        Reactome Pathways for GUCY1A2
        Hemostasis
    Platelet homeostasis
    Nitric oxide stimulates guanylate cyclase


    5         Kegg Pathways  (Kegg details for GUCY1A2):
        Purine metabolism
    Vascular smooth muscle contraction
    Gap junction
    Long-term depression
    Salivary secretion


    GUCY1A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GUCY1A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/85 Interacting proteins for GUCY1A2 (P334023 ENSP000003448744) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1Q129593, ENSP000003457314I2D: score=3 STRING: ENSP00000345731
    DLG3Q927963, ENSP000003634804I2D: score=3 STRING: ENSP00000363480
    DLG4P783523, ENSP000002938134I2D: score=3 STRING: ENSP00000293813
    STUB1Q9UNE73, ENSP000002195484I2D: score=1 STRING: ENSP00000219548
    GUCY1B3Q021533, ENSP000002644244I2D: score=2 STRING: ENSP00000264424
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006182cGMP biosynthetic process ----
    GO:0007165signal transduction TAS1683630
    GO:0007596blood coagulation TAS--
    GO:0030828positive regulation of cGMP biosynthetic process IEA--
    GO:0035556intracellular signal transduction IEA--


    GUCY1A2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GUCY1A2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for GUCY1A2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GUCY1A2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BPIPPNon-competitive GC inhibitor. Also AC inhibitor[325746-94-9]
    A 350619 hydrochlorideSoluble guanylyl cyclase (sGC) activator[538368-27-3]
    CFM 1571 hydrochlorideSoluble guanylyl cyclase (sGC) activator[268725-86-6]
    YC 1Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest[170632-47-0]
    BAY 41-2272Soluble guanylyl cyclase (sGC) activator[256376-24-6]

    6 HMDB Compounds for GUCY1A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 DrugBank Compounds for GUCY1A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Isosorbide MononitrateIHD (see all 6)16051-77-7targetinducer1852778 20089135
    Nitric Oxide-- 10102-43-9targetinducer1852778 20089135

    Search CenterWatch for drugs/clinical trials and news about GUCY1A2 / GCYA2 

    Transcripts
    for GUCY1A2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GUCY1A2 gene (2 alternative transcripts): 
    NM_000855.2  NM_001256424.1  

    Unigene Cluster for GUCY1A2:

    Guanylate cyclase 1, soluble, alpha 2
    Hs.24321  [show with all ESTs]
    Unigene Representative Sequence: NM_001256424
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526355(uc001pjg.1) ENST00000282249(uc010rvo.1 uc009yxn.1)
    ENST00000347596

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK001875.1 AK022090.1 AK025115.1 AK098142.1 BC036599.2 BC047463.1 BC130484.1 BC130488.1 
    BC144033.1 X63282.1 Z50053.1 

    8 DOTS entries:

    DT.113553  DT.306630  DT.309243  DT.95357805  DT.91889380  DT.40266946  DT.95193496  DT.120710184 

    24/35 AceView cDNA sequences (see all 35):

    Z50053 AU133670 AA664160 AI560889 AI189708 NM_000855 BQ011536 AK098142 
    AI633580 X63282 BX279862 CB267250 AI091501 AW874355 BX091019 BE645219 
    AU154906 BU185177 AA456659 BX641588 AI401442 AI417194 H49251 AA490638 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1A2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                      
    SP2:                                      -               


    ECgene alternative splicing isoforms for GUCY1A2

    Expression
    for GUCY1A2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GUCY1A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTTATTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GUCY1A2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GUCY1A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GUCY1A2

    SOURCE GeneReport for Unigene cluster: Hs.24321

    UniProtKB/Swiss-Prot: GCYA2_HUMAN, P33402
    Tissue specificity: Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed
    only in liver, colon and endothelium

        SABiosciences Expression via Pathway-Focused PCR Array including GUCY1A2: 
              Gap Junctions in human mouse rat

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    In Situ
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    Orthologs
    for GUCY1A2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GUCY1A2 gene from 4/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GUCY1A21 guanylate cyclase 1, soluble, alpha 2 82.27(n)
    89.23(a)    		   771678  XM_001233953.2  XP_001233954.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GUCY1A26
    		 --
    		 82(a)
    		 1 ↔ 1
    		 3(189977382-190176801)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003308751 guanylate cyclase soluble subunit alpha-2-like 75.86(n)
    89.27(a)    		   100330875  XM_002667092.2  XP_002667138.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Gycalpha99B1 , 3 optokinetic behavior guanylate cyclase3
    Guanylyl cyclase alpha-subunit at 99B1    		 38(a)3
    50.11(n)1
    41.75(a)1    		   3 99B73
    434931  NM_057740.41  NP_477088.21 


    ENSEMBL Gene Tree for GUCY1A2 (if available)
    TreeFam Gene Tree for GUCY1A2 (if available) 

    Paralogs
    for GUCY1A2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GUCY1A2 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  ADCY72  
    ADCY92  GUCY1B32  ADCY62  GUCY1A32  ADCY12  ADCY42  NPR22  ADCY32  
    4 SIMAP similar genes for GUCY1A2 using alignment to 2 protein entries:     GCYA2_HUMAN (see all proteins):
    GUCY1A3    NPR1    GUCY1B3    GUCY1B2

    GUCY1A2 for paralogs           About GeneDecksing



    Genomic Variants
    for GUCY1A2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5644 NCBI SNPs in GUCY1A2 are shown (see all 5644)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs792913561,2
    		--106544238(+) AGATAA/TCTCGA 2 -- ds50013Minor allele frequency- T:0.16CSA WA EA 240
    rs1824166291,2
    		--106544457(+) GCCTTG/TTCTTT 2 -- ds50010--------
    rs1413594991,2
    		C,--106544463(+) TCTTT-/GTCATA 2 -- ds50010--------
    rs1865969831,2
    		--106544501(+) AATTAG/TAATGT 2 -- ds50010--------
    rs1433059271,2
    		--106544542(+) AGATAA/TTTCAT 2 -- ds50010--------
    rs112118521,2
    		C,F,A,--106544551(+) ATGTTT/AAAAAA 2 -- ds50013Minor allele frequency- A:0.10NA 124
    rs112118531,2
    		C,F,--106544658(+) CCCCCA/TTTCTT 2 -- ds50013Minor allele frequency- T:0.10NA 124
    rs112118541,2
    		A,--106545057(+) GAAAAT/GCAAAG 2 -- ut313Minor allele frequency- G:0.10NA 124
    rs1511525441,2
    		--106545189(+) ACTAC-/TAGA  
                TAAAG     		2 -- ut310--------
    rs112118551,2
    		F,--106545284(+) TTTTTT/AAAAAA 2 -- ut311Minor allele frequency- A:0.08NA 120

    HapMap Linkage Disequilibrium report for GUCY1A2 (106555148 - 106805148 bp, first 250kb of GUCY1A2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for GUCY1A2
         5 CNVs: 34909 101335 86012 66060 101336
         7 Indels: 44814 24619 11579 63010 60062 61188 86013

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    Disorders / Diseases
    for GUCY1A2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GUCY1A2 for disorders           About GeneDecksing

    OMIM gene information: 601244    OMIM disorders: --

    3 diseases for GUCY1A2:    About MalaCards
    familial colorectal cancer    colorectal cancer    retinitis

    Human Genome Epidemiology (HuGE) Navigator: GUCY1A2 (5 documents)

    Export disorders for GUCY1A2 gene to outside databases

    Publications
    for GUCY1A2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GUCY1A2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with GUCY1A2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme. (PubMed id 1683630)1, 2, 3 Harteneck C....Schultz G. (1991)
    2. A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein. (PubMed id 7673142)1, 2 Behrends S.... Koesling D. (1995)
    3. Structural and functional insights into the heme-bindi ng domain of the human soluble guanylate cyclase a2 subunit and heterodimeric a2 b1. (PubMed id 22426988)1 Wang H....Tan X. (2012)
    4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic-pituitary-adrenal axis. (PubMed id 20089135)7 Mancuso C....Preziosi P. (2010)
    7. Gene-Environment Interaction in the Etiology of Mathe matical Ability Using SNP Sets. (PubMed id 20978832)1 Docherty S.J....Plomin R. (2010)
    8. Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation. (PubMed id 19948239)1 Mujoo K....Murad F. (2010)
    9. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
    10. Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase. (PubMed id 17873020)1 Xia T....Catravas J.D. (2007)

    External Searches for GUCY1A2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing GUCY1A2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2977 HGNC: 4684 AceView: GUCY1A2 Ensembl:ENSG00000152402 euGenes: HUgn2977
    ECgene: GUCY1A2 Kegg: 2977 H-InvDB: GUCY1A2

    Other Databases showing GUCY1A2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GUCY1A2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GUCY1A2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GUCY1A2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GUCY1A2 gene:
    Search GeneIP for patents involving GUCY1A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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