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Aliases for GUCY1A2 Gene

Aliases for GUCY1A2 Gene

  • Guanylate Cyclase 1, Soluble, Alpha 2 2 3 5
  • GCS-Alpha-2 3 4
  • EC 4 63
  • GUC1A2 3 4
  • GC-SA2 3
  • GUCSA2 4

External Ids for GUCY1A2 Gene

Previous HGNC Symbols for GUCY1A2 Gene

  • GUC1A2

Previous GeneCards Identifiers for GUCY1A2 Gene

  • GC11M108716
  • GC11M107914
  • GC11M106095
  • GC11M106063
  • GC11M102490
  • GC11M106548

Summaries for GUCY1A2 Gene

Entrez Gene Summary for GUCY1A2 Gene

  • Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for GUCY1A2 Gene

GUCY1A2 (Guanylate Cyclase 1, Soluble, Alpha 2) is a Protein Coding gene. Diseases associated with GUCY1A2 include Kabuki Syndrome 1. Among its related pathways are Platelet activation and CREB Pathway. GO annotations related to this gene include GTP binding and phosphorus-oxygen lyase activity. An important paralog of this gene is GUCY1A3.

UniProtKB/Swiss-Prot for GUCY1A2 Gene

  • Has guanylyl cyclase on binding to the beta-1 subunit.

  • Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.

Tocris Summary for GUCY1A2 Gene

  • Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. There are two main groups of guanylyl cyclase.

Gene Wiki entry for GUCY1A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY1A2 Gene

Genomics for GUCY1A2 Gene

Regulatory Elements for GUCY1A2 Gene

Enhancers for GUCY1A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GUCY1A2 on UCSC Golden Path with GeneCards custom track

Promoters for GUCY1A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GUCY1A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GUCY1A2 Gene

106,674,012 bp from pter
107,018,524 bp from pter
344,513 bases
Minus strand

Genomic View for GUCY1A2 Gene

Genes around GUCY1A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCY1A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCY1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY1A2 Gene

Proteins for GUCY1A2 Gene

  • Protein details for GUCY1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanylate cyclase soluble subunit alpha-2
    Protein Accession:
    Secondary Accessions:
    • A1L4C4
    • B7ZLT5

    Protein attributes for GUCY1A2 Gene

    732 amino acids
    Molecular mass:
    81750 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta chain.
    • There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

    Alternative splice isoforms for GUCY1A2 Gene


neXtProt entry for GUCY1A2 Gene

Proteomics data for GUCY1A2 Gene at MOPED

Post-translational modifications for GUCY1A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GUCY1A2 Gene

Domains & Families for GUCY1A2 Gene

Suggested Antigen Peptide Sequences for GUCY1A2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  • Contains 1 guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY1A2: view

Function for GUCY1A2 Gene

Molecular function for GUCY1A2 Gene

GENATLAS Biochemistry:
guanylate cyclase,soluble,alpha-2 subunit,79kDa,heterodimerizing with GUCY1B1
UniProtKB/Swiss-Prot CatalyticActivity:
GTP = 3,5-cyclic GMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by nitric oxide in the presence of magnesium or manganese ions.
UniProtKB/Swiss-Prot Function:
Has guanylyl cyclase on binding to the beta-1 subunit.
UniProtKB/Swiss-Prot Function:
Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.

Enzyme Numbers (IUBMB) for GUCY1A2 Gene

Gene Ontology (GO) - Molecular Function for GUCY1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0016849 phosphorus-oxygen lyase activity IEA --
genes like me logo Genes that share ontologies with GUCY1A2: view
genes like me logo Genes that share phenotypes with GUCY1A2: view

Animal Models for GUCY1A2 Gene

MGI Knock Outs for GUCY1A2:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GUCY1A2 Gene

Localization for GUCY1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY1A2 Gene


Subcellular locations from

Jensen Localization Image for GUCY1A2 Gene COMPARTMENTS Subcellular localization image for GUCY1A2 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GUCY1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008074 guanylate cyclase complex, soluble IBA --
genes like me logo Genes that share ontologies with GUCY1A2: view

Pathways & Interactions for GUCY1A2 Gene

genes like me logo Genes that share pathways with GUCY1A2: view

Gene Ontology (GO) - Biological Process for GUCY1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IEA --
GO:0030828 positive regulation of cGMP biosynthetic process IEA --
genes like me logo Genes that share ontologies with GUCY1A2: view

No data available for SIGNOR curated interactions for GUCY1A2 Gene

Drugs & Compounds for GUCY1A2 Gene

(11) Drugs for GUCY1A2 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isosorbide Mononitrate Approved Pharma Target, inducer 0
Nitric Oxide Approved Pharma stimulator, Target, inducer 576
Cyclic GMP Experimental Pharma 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(6) Additional Compounds for GUCY1A2 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
A 350619 hydrochloride
CFM 1571 hydrochloride
Guanylin (human)
SIN-1 chloride

(5) Tocris Compounds for GUCY1A2 Gene

Compound Action Cas Number
A 350619 hydrochloride Soluble guanylyl cyclase (sGC) activator 1217201-17-6
CFM 1571 hydrochloride Soluble guanylyl cyclase (sGC) activator 1215548-30-3
Guanylin (human) Endogenous activator of intestinal guanylyl cyclase 183200-12-6
SIN-1 chloride Water-soluble NO donor 16142-27-1
YC 1 Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest 170632-47-0
genes like me logo Genes that share compounds with GUCY1A2: view

Transcripts for GUCY1A2 Gene

mRNA/cDNA for GUCY1A2 Gene

Unigene Clusters for GUCY1A2 Gene

Guanylate cyclase 1, soluble, alpha 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP2: -

Relevant External Links for GUCY1A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GUCY1A2 Gene

mRNA expression in normal human tissues for GUCY1A2 Gene

Protein differential expression in normal tissues from HIPED for GUCY1A2 Gene

This gene is overexpressed in Fetal Brain (19.7), Frontal cortex (13.5), Uterus (11.0), and Bone (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GUCY1A2 Gene

SOURCE GeneReport for Unigene cluster for GUCY1A2 Gene Hs.24321

mRNA Expression by UniProt/SwissProt for GUCY1A2 Gene

Tissue specificity: Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed only in liver, colon and endothelium.
genes like me logo Genes that share expression patterns with GUCY1A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for GUCY1A2 Gene

Orthologs for GUCY1A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY1A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GUCY1A2 35
  • 91.74 (n)
  • 93.97 (a)
GUCY1A2 36
  • 94 (a)
(Canis familiaris)
Mammalia GUCY1A2 35
  • 89.98 (n)
  • 92.49 (a)
GUCY1A2 36
  • 94 (a)
(Mus musculus)
Mammalia Gucy1a2 35
  • 87.03 (n)
  • 90.55 (a)
Gucy1a2 16
Gucy1a2 36
  • 90 (a)
(Pan troglodytes)
Mammalia GUCY1A2 35
  • 99.08 (n)
  • 99.21 (a)
GUCY1A2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Gucy1a2 35
  • 87.17 (n)
  • 91.23 (a)
(Monodelphis domestica)
Mammalia GUCY1A2 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia GUCY1A2 36
  • 91 (a)
(Gallus gallus)
Aves GUCY1A2 35
  • 80.57 (n)
  • 86.49 (a)
GUCY1A2 36
  • 89 (a)
(Anolis carolinensis)
Reptilia GUCY1A2 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy1a2 35
  • 76.01 (n)
  • 81.97 (a)
(Danio rerio)
Actinopterygii GUCY1A2 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gycalpha99B 37
  • 38 (a)
Gycalpha99B 35
  • 50.74 (n)
  • 43.64 (a)
Gycalpha99B 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000280 35
  • 48.09 (n)
  • 41.1 (a)
(Caenorhabditis elegans)
Secernentea gcy-31 37
  • 34 (a)
gcy-37 37
  • 25 (a)
gcy-5 36
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for GUCY1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY1A2 Gene

Gene Tree for GUCY1A2 (if available)
Gene Tree for GUCY1A2 (if available)

Paralogs for GUCY1A2 Gene

Paralogs for GUCY1A2 Gene

(4) SIMAP similar genes for GUCY1A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GUCY1A2: view

Variants for GUCY1A2 Gene

Sequence variations from dbSNP and Humsavar for GUCY1A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_036420 A colorectal cancer sample
VAR_036421 A colorectal cancer sample
rs721625 -- 106,948,831(+) TAGCC(A/G)TCTGG intron-variant
rs721626 -- 106,948,838(+) CTGGA(A/G)AACAA intron-variant
rs879928 -- 106,782,826(+) AGCAG(C/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GUCY1A2 Gene

Variant ID Type Subtype PubMed ID
nsv898359 CNV Loss 21882294
dgv1311n71 CNV Loss 21882294
esv1074601 CNV Insertion 17803354
esv1117785 CNV Insertion 17803354
esv2745032 CNV Deletion 23290073
esv2745033 CNV Deletion 23290073
esv2667580 CNV Deletion 23128226
esv2745034 CNV Deletion 23290073
esv2590906 CNV Deletion 19546169
esv2222990 CNV Deletion 18987734
esv2745035 CNV Deletion 23290073
esv2663324 CNV Deletion 23128226
esv997476 CNV Deletion 20482838
esv9628 CNV Loss 19470904
esv1462632 CNV Deletion 17803354
nsv39784 CNV Loss 16902084
esv2675821 CNV Deletion 23128226
esv5504 CNV Gain 19470904
esv2620868 CNV Insertion 19546169
nsv527620 CNV Loss 19592680
esv2745036 CNV Deletion 23290073
nsv898362 CNV Loss 21882294
nsv474 CNV Loss 18451855
dgv239n67 CNV Loss 20364138
esv28258 CNV Loss 19812545
esv2745037 CNV Deletion 23290073
nsv498770 CNV Loss 21111241
esv2669729 CNV Deletion 23128226
nsv514589 CNV Loss 21397061
esv7117 CNV Gain 19470904
esv9111 CNV Gain 19470904
esv1005254 CNV Insertion 20482838
esv1671016 CNV Insertion 17803354
nsv39525 CNV Insertion 16902084
nsv38495 CNV Insertion 16902084
esv2745038 CNV Deletion 23290073
dgv166e201 CNV Deletion 23290073
esv2661753 CNV Deletion 23128226
esv2745040 CNV Deletion 23290073

Variation tolerance for GUCY1A2 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GUCY1A2 Gene

Disorders for GUCY1A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GUCY1A2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kabuki syndrome 1
  • kabuki syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GUCY1A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GUCY1A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCY1A2 Gene

Publications for GUCY1A2 Gene

  1. Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme. (PMID: 1683630) Harteneck C. … Schultz G. (FEBS Lett. 1991) 2 3 4 67
  2. Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic-pituitary-adrenal axis. (PMID: 20089135) Mancuso C. … Preziosi P. (J. Neurochem. 2010) 25 26
  3. Nitric oxide: physiology, pathophysiology, and pharmacology. (PMID: 1852778) Moncada S. … Higgs E.A. (Pharmacol. Rev. 1991) 25 26
  4. HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways. (PMID: 24666322) Krogh K.A. … Thayer S.A. (J. Neurochem. 2014) 3
  5. Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity. (PMID: 24669844) Seeger F. … Garcin E.D. (Biochemistry 2014) 3

Products for GUCY1A2 Gene

Sources for GUCY1A2 Gene