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Aliases for GUCD1 Gene

Aliases for GUCD1 Gene

  • Guanylyl Cyclase Domain Containing 1 2 3
  • Guanylyl Cyclase Domain-Containing Protein 1 3 4
  • C22orf13 3 4
  • LLN4 3 4
  • CG13760 Gene Product [Drosophila Melanogaster] Homolog 3
  • Chromosome 22 Open Reading Frame 13 2
  • Protein LLN4 4

External Ids for GUCD1 Gene

Previous HGNC Symbols for GUCD1 Gene

  • C22orf13

Previous GeneCards Identifiers for GUCD1 Gene

  • GC22M024937
  • GC22M025034
  • GC22M025180
  • GC22M024564

Summaries for GUCD1 Gene

GeneCards Summary for GUCD1 Gene

GUCD1 (Guanylyl Cyclase Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCD1 Gene

Genomics for GUCD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GUCD1 Gene

24,540,423 bp from pter
24,555,935 bp from pter
15,513 bases
Minus strand

Genomic View for GUCD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GUCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCD1 Gene

No data available for Regulatory Elements for GUCD1 Gene

Proteins for GUCD1 Gene

  • Protein details for GUCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein GUCD1
    Protein Accession:
    Secondary Accessions:
    • B5MCB8
    • B5MCL7
    • Q96Q79
    • Q9BU32

    Protein attributes for GUCD1 Gene

    240 amino acids
    Molecular mass:
    27207 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB68411.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GUCD1 Gene


neXtProt entry for GUCD1 Gene

Proteomics data for GUCD1 Gene at MOPED

Post-translational modifications for GUCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GUCD1 Gene

Domains & Families for GUCD1 Gene

Protein Domains for GUCD1 Gene


Suggested Antigen Peptide Sequences for GUCD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GUCD1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GUCD1 Gene

Function for GUCD1 Gene

Gene Ontology (GO) - Molecular Function for GUCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GUCD1: view

Phenotypes for GUCD1 Gene

genes like me logo Genes that share phenotypes with GUCD1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GUCD1 Gene

Localization for GUCD1 Gene

Subcellular locations from

Jensen Localization Image for GUCD1 Gene COMPARTMENTS Subcellular localization image for GUCD1 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GUCD1 Gene

Pathways & Interactions for GUCD1 Gene

SuperPathways for GUCD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GUCD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for GUCD1 Gene

Drugs & Compounds for GUCD1 Gene

No Compound Related Data Available

Transcripts for GUCD1 Gene

Unigene Clusters for GUCD1 Gene

Guanylyl cyclase domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - -

Relevant External Links for GUCD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GUCD1 Gene

mRNA expression in normal human tissues for GUCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GUCD1 Gene

This gene is overexpressed in Blymphocyte (52.6) and Liver (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GUCD1 Gene

SOURCE GeneReport for Unigene cluster for GUCD1 Gene Hs.9850

genes like me logo Genes that share expression patterns with GUCD1: view

Protein tissue co-expression partners for GUCD1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GUCD1 Gene

Orthologs for GUCD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GUCD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C17H22orf13 35
  • 88.21 (n)
  • 89.08 (a)
C17H22orf13 36
  • 89 (a)
(Canis familiaris)
Mammalia C26H22orf13 35
  • 92.29 (n)
  • 93.01 (a)
-- 36
  • 89 (a)
-- 36
  • 76 (a)
(Mus musculus)
Mammalia Gucd1 35
  • 90.98 (n)
  • 94.76 (a)
Gucd1 16
Gucd1 36
  • 95 (a)
(Pan troglodytes)
Mammalia C22H22orf13 35
  • 99.44 (n)
  • 99.32 (a)
GUCD1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gucd1 35
  • 89.52 (n)
  • 93.45 (a)
(Monodelphis domestica)
Mammalia GUCD1 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia GUCD1 36
  • 76 (a)
(Gallus gallus)
Aves C15H22ORF13 35
  • 72.24 (n)
  • 71.75 (a)
GUCD1 36
  • 72 (a)
(Anolis carolinensis)
Reptilia GUCD1 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gucd1 35
  • 73.93 (n)
  • 73.33 (a)
Str.6101 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7463 35
(Danio rerio)
Actinopterygii gucd1 35
  • 69.49 (n)
  • 69.64 (a)
wufi27d12 35
gucd1 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011198 35
  • 47.71 (n)
  • 38.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13760 35
  • 55.94 (n)
  • 43.56 (a)
CG13760 36
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GC1 35
  • 45.98 (n)
  • 35.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for GUCD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GUCD1 Gene

Gene Tree for GUCD1 (if available)
Gene Tree for GUCD1 (if available)

Paralogs for GUCD1 Gene

(1) SIMAP similar genes for GUCD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GUCD1: view

No data available for Paralogs for GUCD1 Gene

Variants for GUCD1 Gene

Sequence variations from dbSNP and Humsavar for GUCD1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs9704 -- 24,541,002(-) AAAAT(C/T)GTTAG utr-variant-3-prime, nc-transcript-variant
rs11259 -- 24,540,694(+) ATGCA(A/G)CACAG utr-variant-3-prime, nc-transcript-variant
rs730373 -- 24,544,021(-) GCTGG(G/T)GAACT missense, reference, intron-variant
rs738820 -- 24,551,484(+) TGGCC(C/T)GCCAG intron-variant
rs743366 -- 24,543,321(+) CAGAG(A/C)GGGGC intron-variant

Variation tolerance for GUCD1 Gene

Residual Variation Intolerance Score: 18.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUCD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GUCD1 Gene

Disorders for GUCD1 Gene

Relevant External Links for GUCD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GUCD1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GUCD1 Gene

Publications for GUCD1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells. (PMID: 24743017) Bellet M.M. … Della Fazia M.A. (Cell Cycle 2014) 67
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67

Products for GUCD1 Gene

Sources for GUCD1 Gene

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