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Aliases for GUCD1 Gene

Aliases for GUCD1 Gene

  • Guanylyl Cyclase Domain Containing 1 2 3 5
  • Guanylyl Cyclase Domain-Containing Protein 1 3 4
  • C22orf13 3 4
  • LLN4 3 4
  • CG13760 Gene Product [Drosophila Melanogaster] Homolog 3
  • Chromosome 22 Open Reading Frame 13 2
  • Protein GUCD1 3
  • Protein LLN4 4

External Ids for GUCD1 Gene

Previous HGNC Symbols for GUCD1 Gene

  • C22orf13

Previous GeneCards Identifiers for GUCD1 Gene

  • GC22M024937
  • GC22M025034
  • GC22M025180
  • GC22M024564
  • GC22M024634
  • GC22M025237
  • GC22M025446
  • GC22M025628
  • GC22M025814

Summaries for GUCD1 Gene

GeneCards Summary for GUCD1 Gene

GUCD1 (Guanylyl Cyclase Domain Containing 1) is a Protein Coding gene.

Additional gene information for GUCD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCD1 Gene

Genomics for GUCD1 Gene

Regulatory Elements for GUCD1 Gene

Enhancers for GUCD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H024548 2 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +2.5 2474 8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A SPECC1L ENSG00000272973 ZNF70 SGSM1 UPB1 ADORA2A ARL5AP4 LOC100421614 CRIP1P4 RPS10P29
GH22H024577 1.3 ENCODE dbSUPER 5.2 -23.6 -23613 3 PKNOX1 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 ZNF2 ZNF121 FOS ZNF70 SNRPD3 POM121L9P GUCD1 GGT1 CHCHD10
GH22H024563 1.1 ENCODE dbSUPER 5.3 -8.8 -8777 2 PKNOX1 ARID4B RAD21 RARA YY1 ZNF121 RCOR1 MIXL1 CEBPB NFIL3 GUCD1 CHCHD10 GGT1
GH22H024541 1 Ensembl ENCODE dbSUPER 5.3 +13.2 13212 2 POLR2A NR2F1 MAX BATF RAD21 UPB1 ADORA2A-AS1 BCRP3 GUCD1 POM121L9P GC22P024540 PIR61218
GH22H024138 1.4 FANTOM5 Ensembl ENCODE dbSUPER 3.4 +415.5 415509 4 GATA3 HLF SCRT2 EBF1 RUNX3 SUSD2 ENSG00000272787 GUCD1 ENSG00000232545
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GUCD1 on UCSC Golden Path with GeneCards custom track

Promoters for GUCD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000144421 435 3001 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1

Genomic Location for GUCD1 Gene

Chromosome:
22
Start:
24,540,423 bp from pter
End:
24,555,935 bp from pter
Size:
15,513 bases
Orientation:
Minus strand

Genomic View for GUCD1 Gene

Genes around GUCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCD1 Gene

Proteins for GUCD1 Gene

  • Protein details for GUCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NT3-GUCD1_HUMAN
    Recommended name:
    Protein GUCD1
    Protein Accession:
    Q96NT3
    Secondary Accessions:
    • B5MCB8
    • B5MCL7
    • Q96Q79
    • Q9BU32

    Protein attributes for GUCD1 Gene

    Size:
    240 amino acids
    Molecular mass:
    27207 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB68411.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GUCD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GUCD1 Gene

Post-translational modifications for GUCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GUCD1 Gene

Domains & Families for GUCD1 Gene

Gene Families for GUCD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GUCD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GUCD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GUCD1: view

No data available for UniProtKB/Swiss-Prot for GUCD1 Gene

Function for GUCD1 Gene

Gene Ontology (GO) - Molecular Function for GUCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GUCD1: view
genes like me logo Genes that share phenotypes with GUCD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GUCD1 Gene

Localization for GUCD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GUCD1 gene
Compartment Confidence
nucleus 3
extracellular 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GUCD1 Gene

Pathways & Interactions for GUCD1 Gene

SuperPathways for GUCD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GUCD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GUCD1 Gene

Drugs & Compounds for GUCD1 Gene

No Compound Related Data Available

Transcripts for GUCD1 Gene

Unigene Clusters for GUCD1 Gene

Guanylyl cyclase domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for GUCD1 Gene

GeneLoc Exon Structure for
GUCD1
ECgene alternative splicing isoforms for
GUCD1

Expression for GUCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GUCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GUCD1 Gene

This gene is overexpressed in Blymphocyte (52.6) and Liver (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GUCD1 Gene



Protein tissue co-expression partners for GUCD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GUCD1 Gene:

GUCD1

SOURCE GeneReport for Unigene cluster for GUCD1 Gene:

Hs.9850

Evidence on tissue expression from TISSUES for GUCD1 Gene

  • Nervous system(3.3)
  • Liver(2.4)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with GUCD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCD1 Gene

Orthologs for GUCD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GUCD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GUCD1 34
  • 100 (a)
OneToOne
C22H22orf13 33
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia C26H22orf13 33
  • 92.29 (n)
-- 34
  • 89 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gucd1 33 16 34
  • 90.98 (n)
rat
(Rattus norvegicus)
Mammalia Gucd1 33
  • 89.52 (n)
cow
(Bos Taurus)
Mammalia C17H22orf13 34 33
  • 88.21 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GUCD1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GUCD1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C15H22ORF13 33
  • 72.24 (n)
GUCD1 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GUCD1 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gucd1 33
  • 73.93 (n)
Str.6101 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7463 33
zebrafish
(Danio rerio)
Actinopterygii gucd1 33 34
  • 69.49 (n)
wufi27d12 33
fruit fly
(Drosophila melanogaster)
Insecta CG13760 33 34
  • 55.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011198 33
  • 47.71 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GC1 33
  • 45.98 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToOne
Species where no ortholog for GUCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GUCD1 Gene

ENSEMBL:
Gene Tree for GUCD1 (if available)
TreeFam:
Gene Tree for GUCD1 (if available)

Paralogs for GUCD1 Gene

(1) SIMAP similar genes for GUCD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GUCD1: view

No data available for Paralogs for GUCD1 Gene

Variants for GUCD1 Gene

Sequence variations from dbSNP and Humsavar for GUCD1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000063217 -- 24,542,467(+) AAACT(C/T)GGGCC nc-transcript-variant, utr-variant-3-prime
rs1000070163 -- 24,555,808(+) CGGCG(C/G)CCCCC nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs1000258656 -- 24,542,112(+) CCAGC(C/T)CGTTG nc-transcript-variant, utr-variant-3-prime
rs1000351879 -- 24,554,766(+) ACCTT(C/T)CCACC intron-variant, upstream-variant-2KB
rs1000384492 -- 24,555,086(+) TCGAG(C/T)TCCTT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GUCD1 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv2724068 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893463 CNV gain 25118596
nsv1055830 CNV gain 25217958
nsv1057819 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv588744 CNV gain 21841781
nsv7350 OTHER inversion 18451855
nsv9884 CNV gain+loss 18304495

Variation tolerance for GUCD1 Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUCD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GUCD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCD1 Gene

Disorders for GUCD1 Gene

Relevant External Links for GUCD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GUCD1

No disorders were found for GUCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GUCD1 Gene

Publications for GUCD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 60

Products for GUCD1 Gene

Sources for GUCD1 Gene

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