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Aliases for GUCA2B Gene

Aliases for GUCA2B Gene

  • Guanylate Cyclase Activator 2B 2 3 5
  • Guanylate Cyclase Activator 2B (Uroguanylin) 2 3
  • Prepro-Uroguanylin 2 3
  • Uroguanylin 3
  • GCAP-II 3
  • UGN 3

External Ids for GUCA2B Gene

Previous GeneCards Identifiers for GUCA2B Gene

  • GC01P042647
  • GC01P041622
  • GC01P042082
  • GC01P042032
  • GC01P042288
  • GC01P042391
  • GC01P042621
  • GC01P040738

Summaries for GUCA2B Gene

Entrez Gene Summary for GUCA2B Gene

  • This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]

GeneCards Summary for GUCA2B Gene

GUCA2B (Guanylate Cyclase Activator 2B) is a Protein Coding gene. Diseases associated with GUCA2B include colorectal cancer. Among its related pathways are Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include calcium sensitive guanylate cyclase activator activity and guanylate cyclase activator activity.

UniProtKB/Swiss-Prot for GUCA2B Gene

  • Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCA2B Gene

Genomics for GUCA2B Gene

Regulatory Elements for GUCA2B Gene

Genomic Location for GUCA2B Gene

Chromosome:
1
Start:
42,153,421 bp from pter
End:
42,155,824 bp from pter
Size:
2,404 bases
Orientation:
Plus strand

Genomic View for GUCA2B Gene

Genes around GUCA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCA2B Gene

Proteins for GUCA2B Gene

  • Protein details for GUCA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16661-GUC2B_HUMAN
    Recommended name:
    Guanylate cyclase activator 2B
    Protein Accession:
    Q16661
    Secondary Accessions:
    • Q52LV0

    Protein attributes for GUCA2B Gene

    Size:
    112 amino acids
    Molecular mass:
    12069 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GUCA2B Gene

neXtProt entry for GUCA2B Gene

Proteomics data for GUCA2B Gene at MOPED

Post-translational modifications for GUCA2B Gene

No Post-translational modifications

Other Protein References for GUCA2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GUCA2B Gene

Domains & Families for GUCA2B Gene

Gene Families for GUCA2B Gene

Protein Domains for GUCA2B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GUCA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16661

UniProtKB/Swiss-Prot:

GUC2B_HUMAN :
  • Belongs to the guanylin family.
Family:
  • Belongs to the guanylin family.
genes like me logo Genes that share domains with GUCA2B: view

Function for GUCA2B Gene

Molecular function for GUCA2B Gene

GENATLAS Biochemistry:
uroguanylin,guanylate cyclase C binding protein 2B (activator) peptide regulator of intestinal salt and water transport,activating guanylate cyclase C and increasing intracellular cGMP
UniProtKB/Swiss-Prot Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
genes like me logo Genes that share phenotypes with GUCA2B: view

Animal Models for GUCA2B Gene

MGI Knock Outs for GUCA2B:

Animal Model Products

  • Taconic Biosciences Mouse Models for GUCA2B

miRNA for GUCA2B Gene

miRTarBase miRNAs that target GUCA2B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GUCA2B Gene

Localization for GUCA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCA2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GUCA2B Gene COMPARTMENTS Subcellular localization image for GUCA2B gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for GUCA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GUCA2B: view

Pathways & Interactions for GUCA2B Gene

genes like me logo Genes that share pathways with GUCA2B: view

Pathways by source for GUCA2B Gene

1 BioSystems pathway for GUCA2B Gene

Interacting Proteins for GUCA2B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361662%0d%0a9606.ENSP00000254854%0d%0a
Selected Interacting proteins: ENSP00000361662 Q16661-GUC2B_HUMAN for GUCA2B Gene via STRING I2D

SIGNOR curated interactions for GUCA2B Gene

Activates:

Gene Ontology (GO) - Biological Process for GUCA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007588 excretion IEA --
GO:0031284 positive regulation of guanylate cyclase activity TAS 8605041
GO:0045776 negative regulation of blood pressure IEA --
genes like me logo Genes that share ontologies with GUCA2B: view

Drugs & Compounds for GUCA2B Gene

(8) Drugs for GUCA2B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for GUCA2B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GUCA2B: view

Transcripts for GUCA2B Gene

mRNA/cDNA for GUCA2B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GUCA2B Gene

Guanylate cyclase activator 2B (uroguanylin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GUCA2B Gene

No ASD Table

Relevant External Links for GUCA2B Gene

GeneLoc Exon Structure for
GUCA2B
ECgene alternative splicing isoforms for
GUCA2B

Expression for GUCA2B Gene

mRNA expression in normal human tissues for GUCA2B Gene

mRNA differential expression in normal tissues according to GTEx for GUCA2B Gene

This gene is overexpressed in Colon - Transverse (x28.9), Small Intestine - Terminal Ileum (x17.5), and Stomach (x4.1).

Protein differential expression in normal tissues from HIPED for GUCA2B Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GUCA2B Gene



SOURCE GeneReport for Unigene cluster for GUCA2B Gene Hs.32966

mRNA Expression by UniProt/SwissProt for GUCA2B Gene

Q16661-GUC2B_HUMAN
Tissue specificity: Stomach and intestine.
genes like me logo Genes that share expression patterns with GUCA2B: view

Protein tissue co-expression partners for GUCA2B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GUCA2B Gene

Orthologs for GUCA2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GUCA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GUCA2B 36
  • 98 (a)
OneToOne
GUCA2B 35
  • 99.11 (n)
  • 98.21 (a)
cow
(Bos Taurus)
Mammalia GUCA2B 35
  • 82.58 (n)
  • 72.97 (a)
GUCA2B 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GUCA2B 36
  • 70 (a)
OneToOne
GUCA2B 35
  • 81.85 (n)
  • 72.32 (a)
mouse
(Mus musculus)
Mammalia Guca2b 35
  • 75.56 (n)
  • 68.89 (a)
Guca2b 16
Guca2b 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GUCA2B 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GUCA2B 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Guca2b 35
  • 74.07 (n)
  • 67.78 (a)
chicken
(Gallus gallus)
Aves GUCA2A 36
  • 38 (a)
OneToOne
Species with no ortholog for GUCA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GUCA2B Gene

ENSEMBL:
Gene Tree for GUCA2B (if available)
TreeFam:
Gene Tree for GUCA2B (if available)

Paralogs for GUCA2B Gene

(1) SIMAP similar genes for GUCA2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GUCA2B: view

No data available for Paralogs for GUCA2B Gene

Variants for GUCA2B Gene

Sequence variations from dbSNP and Humsavar for GUCA2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2297567 - 42,153,481(-) TCCTG(G/T)CAGGA reference, missense
rs1047047 -- 42,153,468(+) GCTGC(A/C/G/T)TCAGG reference, synonymous-codon
rs12069432 -- 42,153,069(+) GCTCC(A/G)TGACC upstream-variant-2KB
rs12069531 -- 42,153,203(+) AGCCC(A/G)GCACA upstream-variant-2KB
rs12745498 -- 42,156,147(+) GAGGA(A/G)GTGAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GUCA2B Gene

Variant ID Type Subtype PubMed ID
nsv871130 CNV Gain 21882294
nsv527531 CNV Loss 19592680

Variation tolerance for GUCA2B Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUCA2B Gene

HapMap Linkage Disequilibrium report
GUCA2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCA2B Gene

Disorders for GUCA2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for GUCA2B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GUCA2B

Genetic Association Database (GAD)
GUCA2B
Human Genome Epidemiology (HuGE) Navigator
GUCA2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GUCA2B
genes like me logo Genes that share disorders with GUCA2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCA2B Gene

Publications for GUCA2B Gene

  1. Cloning and characterization of a cDNA encoding a precursor for human uroguanylin. (PMID: 8605041) Miyazato M. … Matsukura S. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23 67
  2. Genomic structure and chromosomal localization of human uroguanylin. (PMID: 9268639) Miyazato M. … Matsuo H. (Genomics 1997) 2 3 23
  3. Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension. (PMID: 18037771) Yoshikawa Y. … Usami R. (Hypertens. Res. 2007) 3 23
  4. [Association between uroguanylin G-247A polymorphism and blood pressure/fluid and electrolytes homeostasis]. (PMID: 17582287) Guo H.F. … Wang J.G. (Zhonghua Xin Xue Guan Bing Za Zhi 2007) 3 23
  5. Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts. (PMID: 15780094) SindiA8 A. … Schlatter E. (Kidney Int. 2005) 3 23

Products for GUCA2B Gene

Sources for GUCA2B Gene

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