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Aliases for GUCA2A Gene

Aliases for GUCA2A Gene

  • Guanylate Cyclase Activator 2A (Guanylin) 2 3
  • Guanylate Cyclase-Activating Protein 1 3 4
  • Guanylate Cyclase-Activating Protein I 3 4
  • Prepro-Guanylin 2 3
  • GCAP-I 3 4
  • GUCA2 3 4
  • Guanylate Cyclase Activator 2A (Guanylin 2, Intestinal, Heat-Stable) 3
  • Guanylate Cyclase Activator 2A 4
  • STARA 3

External Ids for GUCA2A Gene

Previous HGNC Symbols for GUCA2A Gene

  • GUCA2

Previous GeneCards Identifiers for GUCA2A Gene

  • GC01M042656
  • GC01M041631
  • GC01M042091
  • GC01M042041
  • GC01M042297
  • GC01M042400
  • GC01M042628
  • GC01M040747

Summaries for GUCA2A Gene

GeneCards Summary for GUCA2A Gene

GUCA2A (Guanylate Cyclase Activator 2A (Guanylin)) is a Protein Coding gene. Diseases associated with GUCA2A include retinitis pigmentosa 48 and acromesomelic dysplasia. Among its related pathways are Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include hormone activity and guanylate cyclase activator activity.

UniProtKB/Swiss-Prot for GUCA2A Gene

  • Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCA2A Gene

Genomics for GUCA2A Gene

Regulatory Elements for GUCA2A Gene

Genomic Location for GUCA2A Gene

Chromosome:
1
Start:
42,162,691 bp from pter
End:
42,164,724 bp from pter
Size:
2,034 bases
Orientation:
Minus strand

Genomic View for GUCA2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GUCA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCA2A Gene

Proteins for GUCA2A Gene

  • Protein details for GUCA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02747-GUC2A_HUMAN
    Recommended name:
    Guanylin
    Protein Accession:
    Q02747

    Protein attributes for GUCA2A Gene

    Size:
    115 amino acids
    Molecular mass:
    12388 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GUCA2A Gene

neXtProt entry for GUCA2A Gene

Proteomics data for GUCA2A Gene at MOPED

Post-translational modifications for GUCA2A Gene

No Post-translational modifications

Other Protein References for GUCA2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GUCA2A Gene

Domains & Families for GUCA2A Gene

Gene Families for GUCA2A Gene

Protein Domains for GUCA2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GUCA2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02747

UniProtKB/Swiss-Prot:

GUC2A_HUMAN :
  • Belongs to the guanylin family.
Family:
  • Belongs to the guanylin family.
genes like me logo Genes that share domains with GUCA2A: view

Function for GUCA2A Gene

Molecular function for GUCA2A Gene

GENATLAS Biochemistry:
guanylin,cyclase C binding protein 2A,increasing intracellular cGMP
UniProtKB/Swiss-Prot Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins

Gene Ontology (GO) - Molecular Function for GUCA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity NAS 7947768
GO:0030250 guanylate cyclase activator activity NAS 8095028
genes like me logo Genes that share ontologies with GUCA2A: view
genes like me logo Genes that share phenotypes with GUCA2A: view

Animal Models for GUCA2A Gene

MGI Knock Outs for GUCA2A:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCA2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for GUCA2A Gene

Localization for GUCA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCA2A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GUCA2A Gene COMPARTMENTS Subcellular localization image for GUCA2A gene
Compartment Confidence
extracellular 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GUCA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 8095028
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GUCA2A: view

Pathways & Interactions for GUCA2A Gene

genes like me logo Genes that share pathways with GUCA2A: view

Pathways by source for GUCA2A Gene

1 BioSystems pathway for GUCA2A Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GUCA2A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349493%0d%0a9606.ENSP00000261170%0d%0a
Selected Interacting proteins: Q02747-GUC2A_HUMAN ENSP00000349493 for GUCA2A Gene via I2D STRING

SIGNOR curated interactions for GUCA2A Gene

Activates:

Gene Ontology (GO) - Biological Process for GUCA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031284 positive regulation of guanylate cyclase activity NAS 8095028
genes like me logo Genes that share ontologies with GUCA2A: view

Drugs & Compounds for GUCA2A Gene

(16) Drugs for GUCA2A Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bumetanide Approved Pharma Inhibition, Inhibitor NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) cotransporter inhibitor 13
Isoproterenol Approved Pharma Full agonist, Agonist 15
Nitric Oxide Approved Pharma 540
Forskolin Experimental Pharma 0
Potassium Experimental Pharma 0

(10) Additional Compounds for GUCA2A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo cgmp
bicarbonate
chloride
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
Enterotoxin
genes like me logo Genes that share compounds with GUCA2A: view

Transcripts for GUCA2A Gene

mRNA/cDNA for GUCA2A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GUCA2A Gene

Guanylate cyclase activator 2A (guanylin):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCA2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCA2A Gene

No ASD Table

Relevant External Links for GUCA2A Gene

GeneLoc Exon Structure for
GUCA2A
ECgene alternative splicing isoforms for
GUCA2A

Expression for GUCA2A Gene

mRNA expression in normal human tissues for GUCA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GUCA2A Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x26.8) and Colon - Transverse (x25.0).

Protein differential expression in normal tissues from HIPED for GUCA2A Gene

This gene is overexpressed in Urine (63.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GUCA2A Gene



SOURCE GeneReport for Unigene cluster for GUCA2A Gene Hs.778

mRNA Expression by UniProt/SwissProt for GUCA2A Gene

Q02747-GUC2A_HUMAN
Tissue specificity: Highly expressed in ileum and colon. Found in plasma
genes like me logo Genes that share expression patterns with GUCA2A: view

Protein tissue co-expression partners for GUCA2A Gene

Primer Products

In Situ Assay Products

Orthologs for GUCA2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for GUCA2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GUCA2A 35
  • 81.65 (n)
  • 77.98 (a)
GUCA2A 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GUCA2A 35
  • 75.84 (n)
  • 72.48 (a)
GUCA2A 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Guca2a 35
  • 75.07 (n)
  • 66.96 (a)
Guca2a 16
Guca2a 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GUCA2A 35
  • 99.13 (n)
  • 98.26 (a)
GUCA2A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Guca2a 35
  • 74.2 (n)
  • 66.96 (a)
oppossum
(Monodelphis domestica)
Mammalia GUCA2A 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GUCA2A 36
  • 48 (a)
OneToOne
Species with no ortholog for GUCA2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GUCA2A Gene

ENSEMBL:
Gene Tree for GUCA2A (if available)
TreeFam:
Gene Tree for GUCA2A (if available)

Paralogs for GUCA2A Gene

(1) SIMAP similar genes for GUCA2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GUCA2A: view

No data available for Paralogs for GUCA2A Gene

Variants for GUCA2A Gene

Sequence variations from dbSNP and Humsavar for GUCA2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs638710 -- 42,166,673(-) GCGCA(C/T)ACATG upstream-variant-2KB
rs2071499 - 42,164,693(-) GCTCT(C/T)CGCAC reference, missense
rs2071500 -- 42,163,675(-) GCCAG(C/T)ACGGG intron-variant
rs2232219 -- 42,163,744(-) CCCAC(A/T)GTGGA intron-variant
rs2232220 -- 42,163,722(-) CCATA(C/T)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GUCA2A Gene

Variant ID Type Subtype PubMed ID
nsv871130 CNV Gain 21882294
nsv527531 CNV Loss 19592680

Variation tolerance for GUCA2A Gene

Residual Variation Intolerance Score: 79.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.70; 89.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUCA2A Gene

HapMap Linkage Disequilibrium report
GUCA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCA2A Gene

Disorders for GUCA2A Gene

MalaCards: The human disease database

(5) MalaCards diseases for GUCA2A Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 48
  • rp48
acromesomelic dysplasia
  • acromesomelic dwarfism
cone-rod dystrophy
  • cone-rod dystrophy 5
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
colorectal cancer
  • colorectal cancer, somatic
- elite association

Relevant External Links for GUCA2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GUCA2A
genes like me logo Genes that share disorders with GUCA2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCA2A Gene

Publications for GUCA2A Gene

  1. Analysis of the human guanylin gene and the processing and cellular localization of the peptide. (PMID: 7892222) Hill O. … Maegert H.-J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 23 67
  2. Human guanylin: cDNA isolation, structure, and activity. (PMID: 1327879) Wiegand R.C. … Currie M.G. (FEBS Lett. 1992) 2 23 67
  3. Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. (PMID: 20152158) Orban T. … Palczewski K. (Structure 2010) 23 67
  4. GCAP1 mutations associated with autosomal dominant cone dystrophy. (PMID: 20238026) Jiang L. … Baehr W. (Adv. Exp. Med. Biol. 2010) 23 67
  5. Rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) calcium-modulated transduction system in the sperm. (PMID: 19111294) Jankowska A. … Warchol J.B. (Fertil. Steril. 2010) 23 67

Products for GUCA2A Gene

Sources for GUCA2A Gene

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