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Aliases for GUCA2A Gene

Aliases for GUCA2A Gene

  • Guanylate Cyclase Activator 2A 2 3 4 5
  • Guanylate Cyclase Activator 2A (Guanylin) 2 3
  • Guanylate Cyclase-Activating Protein 1 3 4
  • Guanylate Cyclase-Activating Protein I 3 4
  • Prepro-Guanylin 2 3
  • GCAP-I 3 4
  • GUCA2 3 4
  • Guanylate Cyclase Activator 2A (Guanylin 2, Intestinal, Heat-Stable) 3
  • STARA 3

External Ids for GUCA2A Gene

Previous HGNC Symbols for GUCA2A Gene

  • GUCA2

Previous GeneCards Identifiers for GUCA2A Gene

  • GC01M042656
  • GC01M041631
  • GC01M042091
  • GC01M042041
  • GC01M042297
  • GC01M042400
  • GC01M042628
  • GC01M040747

Summaries for GUCA2A Gene

GeneCards Summary for GUCA2A Gene

GUCA2A (Guanylate Cyclase Activator 2A) is a Protein Coding gene. Diseases associated with GUCA2A include Retinitis Pigmentosa 48 and Cone-Rod Dystrophy. Among its related pathways are Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include hormone activity and guanylate cyclase activator activity.

UniProtKB/Swiss-Prot for GUCA2A Gene

  • Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCA2A Gene

Genomics for GUCA2A Gene

Regulatory Elements for GUCA2A Gene

Enhancers for GUCA2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GUCA2A on UCSC Golden Path with GeneCards custom track

Genomic Location for GUCA2A Gene

42,162,691 bp from pter
42,164,724 bp from pter
2,034 bases
Minus strand

Genomic View for GUCA2A Gene

Genes around GUCA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCA2A Gene

Proteins for GUCA2A Gene

  • Protein details for GUCA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for GUCA2A Gene

    115 amino acids
    Molecular mass:
    12388 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GUCA2A Gene

neXtProt entry for GUCA2A Gene

Proteomics data for GUCA2A Gene at MOPED

Post-translational modifications for GUCA2A Gene

No Post-translational modifications

Other Protein References for GUCA2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GUCA2A Gene

Domains & Families for GUCA2A Gene

Gene Families for GUCA2A Gene

Protein Domains for GUCA2A Gene


Suggested Antigen Peptide Sequences for GUCA2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the guanylin family.
  • Belongs to the guanylin family.
genes like me logo Genes that share domains with GUCA2A: view

Function for GUCA2A Gene

Molecular function for GUCA2A Gene

GENATLAS Biochemistry:
guanylin,cyclase C binding protein 2A,increasing intracellular cGMP
UniProtKB/Swiss-Prot Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
genes like me logo Genes that share phenotypes with GUCA2A: view

Animal Models for GUCA2A Gene

MGI Knock Outs for GUCA2A:

Animal Model Products

  • Taconic Biosciences Mouse Models for GUCA2A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GUCA2A Gene

Localization for GUCA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCA2A Gene


Subcellular locations from

Jensen Localization Image for GUCA2A Gene COMPARTMENTS Subcellular localization image for GUCA2A gene
Compartment Confidence
extracellular 5
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for GUCA2A Gene

Pathways & Interactions for GUCA2A Gene

genes like me logo Genes that share pathways with GUCA2A: view

Pathways by source for GUCA2A Gene

1 BioSystems pathway for GUCA2A Gene

Interacting Proteins for GUCA2A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000349493 Q02747-GUC2A_HUMAN for GUCA2A Gene via STRING I2D

SIGNOR curated interactions for GUCA2A Gene


Gene Ontology (GO) - Biological Process for GUCA2A Gene


Drugs & Compounds for GUCA2A Gene

(16) Drugs for GUCA2A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for GUCA2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GUCA2A: view

Transcripts for GUCA2A Gene

mRNA/cDNA for GUCA2A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GUCA2A Gene

Guanylate cyclase activator 2A (guanylin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GUCA2A Gene

No ASD Table

Relevant External Links for GUCA2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GUCA2A Gene

mRNA expression in normal human tissues for GUCA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GUCA2A Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x26.8) and Colon - Transverse (x25.0).

Protein differential expression in normal tissues from HIPED for GUCA2A Gene

This gene is overexpressed in Urine (63.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GUCA2A Gene

SOURCE GeneReport for Unigene cluster for GUCA2A Gene Hs.778

mRNA Expression by UniProt/SwissProt for GUCA2A Gene

Tissue specificity: Highly expressed in ileum and colon. Found in plasma.
genes like me logo Genes that share expression patterns with GUCA2A: view

Protein tissue co-expression partners for GUCA2A Gene

Primer Products

Orthologs for GUCA2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for GUCA2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GUCA2A 35
  • 81.65 (n)
  • 77.98 (a)
  • 72 (a)
(Canis familiaris)
Mammalia GUCA2A 35
  • 75.84 (n)
  • 72.48 (a)
  • 68 (a)
(Mus musculus)
Mammalia Guca2a 35
  • 75.07 (n)
  • 66.96 (a)
Guca2a 16
Guca2a 36
  • 66 (a)
(Pan troglodytes)
Mammalia GUCA2A 35
  • 99.13 (n)
  • 98.26 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Guca2a 35
  • 74.2 (n)
  • 66.96 (a)
(Monodelphis domestica)
Mammalia GUCA2A 36
  • 57 (a)
(Anolis carolinensis)
Reptilia GUCA2A 36
  • 48 (a)
Species with no ortholog for GUCA2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GUCA2A Gene

Gene Tree for GUCA2A (if available)
Gene Tree for GUCA2A (if available)

Paralogs for GUCA2A Gene

(1) SIMAP similar genes for GUCA2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GUCA2A: view

No data available for Paralogs for GUCA2A Gene

Variants for GUCA2A Gene

Sequence variations from dbSNP and Humsavar for GUCA2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2071499 - 42,164,693(-) GCTCT(C/T)CGCAC reference, missense
rs638710 -- 42,166,673(-) GCGCA(C/T)ACATG upstream-variant-2KB
rs2232219 -- 42,163,744(-) CCCAC(A/T)GTGGA intron-variant
rs2232220 -- 42,163,722(-) CCATA(C/T)GCCAC intron-variant
rs2232221 -- 42,163,521(-) AGGAA(A/C/G/T)TTTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GUCA2A Gene

Variant ID Type Subtype PubMed ID
nsv871130 CNV Gain 21882294
nsv527531 CNV Loss 19592680

Variation tolerance for GUCA2A Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.70; 89.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GUCA2A Gene

Disorders for GUCA2A Gene

MalaCards: The human disease database

(4) MalaCards diseases for GUCA2A Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 48
  • rp48
cone-rod dystrophy
  • cone-rod dystrophy 5
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
acromesomelic dysplasia
  • acromesomelic dwarfism
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GUCA2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GUCA2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCA2A Gene

Publications for GUCA2A Gene

  1. Human guanylin: cDNA isolation, structure, and activity. (PMID: 1327879) Wiegand R.C. … Currie M.G. (FEBS Lett. 1992) 2 3 4 23 67
  2. Analysis of the human guanylin gene and the processing and cellular localization of the peptide. (PMID: 7892222) Hill O. … Maegert H.-J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 23
  3. Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy. (PMID: 20213926) Dell'Orco D. … Koch K.W. (Cell. Mol. Life Sci. 2010) 3 23
  4. [Differential expression of guanylin in colorectal cancer]. (PMID: 19742348) Chen Y.B. … Li D.C. (Zhonghua Wei Chang Wai Ke Za Zhi 2009) 3 23
  5. Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts. (PMID: 15780094) SindiA8 A. … Schlatter E. (Kidney Int. 2005) 3 23

Products for GUCA2A Gene

Sources for GUCA2A Gene