GUCA1C Gene
protein-coding GIFtS: 50
GCID: GC03M108626
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guanylate cyclase activator 1C
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Aliases
for GUCA1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Guanylate Cyclase Activator 1C1 2 3 | | GCAP31 2 3 5 | | GCAP 32 3 | | Guanylyl Cyclase-Activating Protein 32 |
Export aliases for GUCA1C gene to outside databasesPrevious GC identifers: GC03M105420 GC03M108154 GC03M109907 GC03M109948 GC03M109949 GC03M110109 GC03M106000 |
Summaries
for GUCA1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GUC1C_HUMAN, O95843Function: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylylcyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC)is a key event in recovery of the dark state of rod photoreceptors following light exposure
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Genomic Views
for GUCA1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GUCA1C gene promoter:
CREB MEF-2A Nkx2-2 FOXO4 Meis-1a aMEF-2 Pax-4a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GUCA1C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GUCA1C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.1 Ensembl cytogenetic band: 3q13.13 HGNC cytogenetic band: 3q13.1GUCA1C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M108626: view genomic region
(about GC identifiers)
Start:
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108,626,639 bp from pter |
End:
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108,672,742 bp from pter |
Size:
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46,104 bases |
Orientation:
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minus strand |
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Proteins
for GUCA1C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GUC1C_HUMAN, O95843 (See
protein sequence)Recommended Name: Guanylyl cyclase-activating protein 3 Size: 209 amino acids; 23822 Da
Miscellaneous: Binds three calcium ions (By similarity)
1 PDB 3D structure from  and Proteopedia  for GUCA1C:2GGZ (3D)
Secondary accessions: O95844 Q9UNM0Alternative splicing: 2 isoforms: O95843-1 O95843-2 Explore the universe of human proteins at neXtProt for GUCA1C: NX_O95843
GUCA1C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005450.3
ENSEMBL proteins: ENSP00000377535 ENSP00000261047 ENSP00000417761
Human Recombinant Protein Products:
GUCA1C Antibody Products:
Assay Products for GUCA1C: |
Protein
Domains /
Families
for GUCA1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GUCA1C for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95843ProtoNet protein and cluster: O95843 UniProtKB/Swiss-Prot: GUC1C_HUMAN, O95843Similarity: Contains 4 EF-hand domains |
Function
for GUCA1C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GUC1C_HUMAN, O95843Function: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylylcyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC)is a key event in recovery of the dark state of rod photoreceptors following light exposure Genatlas biochemistry entry for GUCA1C:guanylate cyclase activating protein 1C,specifically expressed in phosphoreceptors
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GUCA1C
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GUCA1C |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- | | GO:0008048 | calcium sensitive guanylate cyclase activator activity |
TAS | 10037746 |
GUCA1C for ontologies About GeneDecksing
|
Pathways & Interactions
for GUCA1C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Visual signal transduction- Rods | | | 2 | Visual Cycle in Retinal Rods | | | 3 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GUCA1C
2  BioSystems Pathways for GUCA1C
2 
Kegg Pathways (Kegg details for GUCA1C):
GUCA1C for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GUCA1C
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for GUCA1C (ENSP000002610474) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
GUCA1C for ontologies About GeneDecksing
|
Drugs & Compounds
for GUCA1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GUCA1C for compounds About GeneDecksing
 Browse Tocris compounds for GUCA1C
1 HMDB Compound for GUCA1C About this table
1 Novoseek chemical compound relationship for GUCA1C gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| guanylate |
58.7 |
2 |
15486694 (1), 11860507 (1) |
Search CenterWatch for drugs/clinical trials and news about GUCA1C / GUC1C
|
Transcripts
for GUCA1C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GUCA1C gene: NM_005459.3 Unigene Cluster for GUCA1C: Guanylate cyclase activator 1C Hs.233363 [show with all ESTs]Unigene Representative Sequence: NM_0054593 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393963 ENST00000261047(uc003dxj.2 uc003dxk.2) ENST00000471108
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GUCA1C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GUCA1C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GUCA1C (NM_005459) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GUCA1C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GUCA1C |
Additional cDNA sequence: AB593147.1 AF110002.1 AF110003.1 BC103993.1 BC103994.1 3 DOTS entries: DT.95362461 DT.432360 DT.100748097 24/26 AceView cDNA sequences (see all 26): BU726199 AI917103 C20850 AW963468 BM695917 AW594508 AW337860 AA365180 AI969019 BM666986 AF110003 NM_005459 AA364442 BM663382 AA365179 BU736658 BU160027 AF110002 BX282721 BM704487 AA364464 BM685830 AV732101 BG217579
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for GUCA1C About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b |
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| SP1: | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GUCA1C
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Expression
for GUCA1C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GUCA1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GUCA1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GUCA1C
SOURCE GeneReport for Unigene cluster: Hs.233363
UniProtKB/Swiss-Prot: GUC1C_HUMAN, O95843Tissue specificity: Retina
SABiosciences Custom PCR Arrays for GUCA1C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GUCA1C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GUCA1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GUCA1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GUCA1C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GUCA1C |
Orthologs
for GUCA1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GUCA1C gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for GUCA1C (if available)
TreeFam Gene Tree for GUCA1C (if available) |
Paralogs
for GUCA1C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GUCA1C gene
- HPCA2 KCNIP32 KCNIP42 GUCA1A2 KCNIP12 RCVRN2 HPCAL12 GUCA1B2
- NCALD2 KCNIP22 HPCAL42 NCS12 VSNL12
16 SIMAP similar genes for GUCA1C using alignment to 4 protein entries: GUC1C_HUMAN (see all proteins):GUCA1A NCALD GUCA1B HPCA KCNIP2 HPCAL1
KCNIP1 VSNL1 CALM3 DKFZp686E1183 DKFZp781K1922 HPCAL4
KCNIP3 RCV1 RCVRN NCS1
GUCA1C for paralogs About GeneDecksing
|
Genomic Variants
for GUCA1C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GUCA1C (108626639 - 108672742 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GUCA1C
2 CNVs: 50899 98399 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GUCA1C |
|
Disorders
/ Diseases
for GUCA1C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GUCA1C for disorders About GeneDecksing
OMIM gene information: 605128
OMIM disorders: --
3  diseases for GUCA1C: About MalaCardscone dystrophy retinitis neuronitis
Export disorders for GUCA1C gene to outside databases
|
Publications
for GUCA1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GUCA1C gene integrated from 9 sources:
(articles sorted by number of sources associating them with GUCA1C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular characterization of a third member of the guanylyl cyclase- activating protein subfamily. (PubMed id 10037746)1, 2, 3, 9 Haeseleer F.... Palczewski K. (1999)
- Characterization of retinal guanylate cyclase-activat ing protein 3 (GCAP3) from zebrafish to man. (PubMed id 11860507)1, 3, 9 Imanishi Y....Palczewski K. (2002)
- The crystal structure of GCAP3 suggests molecular mechanism of GCAP- linked cone dystrophies. (PubMed id 16626734)1, 2 Stephen R.... Sousa M.C. (2006)
- Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). (PubMed id 15486694)9 Imanishi Y....Baehr W. (2004)
- GCAPs: Ca2+-sensitive regulators of retGC. (PubMed id 12596930)9 Gorczyca W.A. and Sokal I. (2002)
|
External Searches for GUCA1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GUCA1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GUCA1C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GUCA1C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GUCA1C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GUCA1C gene:
Search GeneIP for patents involving GUCA1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GUCA1C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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