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Aliases for GUCA1C Gene

Aliases for GUCA1C Gene

  • Guanylate Cyclase Activator 1C 2 3 4
  • GCAP 3 3 4
  • GCAP3 3 4
  • Guanylyl Cyclase-Activating Protein 3 2

External Ids for GUCA1C Gene

Previous GeneCards Identifiers for GUCA1C Gene

  • GC03M105420
  • GC03M108154
  • GC03M109907
  • GC03M109948
  • GC03M109949
  • GC03M110109
  • GC03M108626
  • GC03M106000

Summaries for GUCA1C Gene

GeneCards Summary for GUCA1C Gene

GUCA1C (Guanylate Cyclase Activator 1C) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Visual Cycle in Retinal Rods. GO annotations related to this gene include calcium ion binding and calcium sensitive guanylate cyclase activator activity. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for GUCA1C Gene

  • Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCA1C Gene

Genomics for GUCA1C Gene

Regulatory Elements for GUCA1C Gene

Genomic Location for GUCA1C Gene

Chromosome:
3
Start:
108,907,644 bp from pter
End:
108,955,188 bp from pter
Size:
47,545 bases
Orientation:
Minus strand

Genomic View for GUCA1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GUCA1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCA1C Gene

Proteins for GUCA1C Gene

  • Protein details for GUCA1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95843-GUC1C_HUMAN
    Recommended name:
    Guanylyl cyclase-activating protein 3
    Protein Accession:
    O95843
    Secondary Accessions:
    • O95844
    • Q9UNM0

    Protein attributes for GUCA1C Gene

    Size:
    209 amino acids
    Molecular mass:
    23822 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Binds three calcium ions.

    Three dimensional structures from OCA and Proteopedia for GUCA1C Gene

    Alternative splice isoforms for GUCA1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GUCA1C Gene

Proteomics data for GUCA1C Gene at MOPED

Post-translational modifications for GUCA1C Gene

No Post-translational modifications

Other Protein References for GUCA1C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GUCA1C Gene

Domains & Families for GUCA1C Gene

Gene Families for GUCA1C Gene

Protein Domains for GUCA1C Gene

Suggested Antigen Peptide Sequences for GUCA1C Gene

Graphical View of Domain Structure for InterPro Entry

O95843

UniProtKB/Swiss-Prot:

GUC1C_HUMAN :
  • Contains 4 EF-hand domains.
Domain:
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with GUCA1C: view

Function for GUCA1C Gene

Molecular function for GUCA1C Gene

GENATLAS Biochemistry:
guanylate cyclase activating protein 1C,specifically expressed in phosphoreceptors
UniProtKB/Swiss-Prot Function:
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure

Gene Ontology (GO) - Molecular Function for GUCA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008048 calcium sensitive guanylate cyclase activator activity TAS 10037746
genes like me logo Genes that share ontologies with GUCA1C: view

Phenotypes for GUCA1C Gene

GenomeRNAi human phenotypes for GUCA1C:
genes like me logo Genes that share phenotypes with GUCA1C: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCA1C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GUCA1C Gene

Localization for GUCA1C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GUCA1C Gene COMPARTMENTS Subcellular localization image for GUCA1C gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for GUCA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097381 photoreceptor disc membrane TAS --
genes like me logo Genes that share ontologies with GUCA1C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GUCA1C Gene

Pathways & Interactions for GUCA1C Gene

genes like me logo Genes that share pathways with GUCA1C: view

Pathways by source for GUCA1C Gene

Interacting Proteins for GUCA1C Gene

Gene Ontology (GO) - Biological Process for GUCA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10037746
GO:0007601 visual perception TAS 10037746
GO:0007603 phototransduction, visible light TAS --
GO:0016056 rhodopsin mediated signaling pathway TAS --
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with GUCA1C: view

No data available for SIGNOR curated interactions for GUCA1C Gene

Drugs & Compounds for GUCA1C Gene

(1) Drugs for GUCA1C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0

(1) Additional Compounds for GUCA1C Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
guanylate
genes like me logo Genes that share compounds with GUCA1C: view

Transcripts for GUCA1C Gene

Unigene Clusters for GUCA1C Gene

Guanylate cyclase activator 1C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GUCA1C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCA1C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for GUCA1C Gene

GeneLoc Exon Structure for
GUCA1C
ECgene alternative splicing isoforms for
GUCA1C

Expression for GUCA1C Gene

mRNA expression in normal human tissues for GUCA1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GUCA1C Gene

This gene is overexpressed in Pancreas (x33.1) and Heart - Left Ventricle (x7.4).

SOURCE GeneReport for Unigene cluster for GUCA1C Gene Hs.233363

mRNA Expression by UniProt/SwissProt for GUCA1C Gene

O95843-GUC1C_HUMAN
Tissue specificity: Retina
genes like me logo Genes that share expression patterns with GUCA1C: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GUCA1C Gene

Orthologs for GUCA1C Gene

This gene was present in the common ancestor of chordates.

Orthologs for GUCA1C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GUCA1C 35
  • 86.28 (n)
  • 78.85 (a)
GUCA1C 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GUCA1C 35
  • 99.2 (n)
  • 98.56 (a)
GUCA1C 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GUCA1C 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GUCA1C 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves GUCA1C 35
  • 69.26 (n)
  • 60 (a)
GUCA1C 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GUCA1C 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia guca1c 35
  • 68.81 (n)
  • 63.64 (a)
zebrafish
(Danio rerio)
Actinopterygii guca1c 36
  • 45 (a)
OneToMany
GUCA1C (3 of 3) 36
  • 45 (a)
OneToMany
guca1d 36
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.795 36
  • 30 (a)
OneToMany
Species with no ortholog for GUCA1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GUCA1C Gene

ENSEMBL:
Gene Tree for GUCA1C (if available)
TreeFam:
Gene Tree for GUCA1C (if available)

Paralogs for GUCA1C Gene

genes like me logo Genes that share paralogs with GUCA1C: view

Variants for GUCA1C Gene

Sequence variations from dbSNP and Humsavar for GUCA1C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs751298 -- 108,937,304(+) ATCCC(C/T)GGGTG intron-variant
rs751299 -- 108,937,672(+) AGGCA(C/T)TGTGC intron-variant
rs921171 -- 108,917,619(+) TCTCA(C/T)TTGGC intron-variant
rs1470565 -- 108,932,340(+) AAAAA(A/C)AAAAA intron-variant
rs1470566 -- 108,932,341(+) AAAAC(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GUCA1C Gene

Variant ID Type Subtype PubMed ID
nsv829661 CNV Gain 17160897
nsv522119 CNV Gain 19592680
nsv829662 CNV Gain 17160897
esv2666522 CNV Deletion 23128226
esv2660605 CNV Deletion 23128226
nsv520181 CNV Loss 19592680
nsv829663 CNV Gain 17160897
esv2634761 CNV Deletion 19546169
nsv877327 CNV Loss 21882294

Variation tolerance for GUCA1C Gene

Residual Variation Intolerance Score: 70.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.34; 94.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUCA1C Gene

HapMap Linkage Disequilibrium report
GUCA1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCA1C Gene

Disorders for GUCA1C Gene

Relevant External Links for GUCA1C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GUCA1C
genes like me logo Genes that share disorders with GUCA1C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GUCA1C Gene

Publications for GUCA1C Gene

  1. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. (PMID: 11860507) Imanishi Y. … Palczewski K. (Eur. J. Neurosci. 2002) 2 23 67
  2. Molecular characterization of a third member of the guanylyl cyclase- activating protein subfamily. (PMID: 10037746) Haeseleer F. … Palczewski K. (J. Biol. Chem. 1999) 2 23 67
  3. Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). (PMID: 15486694) Imanishi Y. … Baehr W. (J. Mol. Evol. 2004) 23 67
  4. GCAPs: Ca2+-sensitive regulators of retGC. (PMID: 12596930) Gorczyca W.A. … Sokal I. (Adv. Exp. Med. Biol. 2002) 23 67
  5. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 67

Products for GUCA1C Gene

Sources for GUCA1C Gene

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